V E Hermosilla, L Gyenis, A J Rabalski, M E Armijo, P Sepúlveda, F Duprat, D Benítez-Riquelme, F Fuentes-Villalobos, A Quiroz, M I Hepp, C Farkas, M Mastel, I González-Chavarría, R Jackstadt, D W Litchfield, A F Castro, R Pincheira
Spalt-like proteins are Zinc finger transcription factors from Caenorhabditis elegans to vertebrates, with critical roles in development. In vertebrates, four paralogues have been identified (SALL1-4), and SALL2 is the family's most dissimilar member. SALL2 is required during brain and eye development. It is downregulated in cancer and acts as a tumor suppressor, promoting cell cycle arrest and cell death. Despite its critical functions, information about SALL2 regulation is scarce. Public data indicate that SALL2 is ubiquitinated and phosphorylated in several residues along the protein, but the mechanisms, biological consequences, and enzymes responsible for these modifications remain unknown...
March 16, 2024: Cell Death & Disease