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https://www.readbyqxmd.com/read/28630189/in-vitro-activity-of-delafloxacin-and-microbiological-response-against-fluoroquinolone-susceptible-and-non-susceptible-s-aureus-isolates-from-two-phase-3-studies-of-acute-bacterial-skin-and-skin-structure-infections-absssi
#1
S McCurdy, L Lawrence, M Quintas, L Woosley, R Flamm, C Tseng, S Cammarata
Delafloxacin is an investigational anionic fluoroquinolone antibiotic with broad spectrum in vitro activity, including Gram-positive organisms, Gram-negative organisms, atypical organisms, and anaerobes. The in vitro activity of delafloxacin and percent microbiological response in subjects infected with fluoroquinolone susceptible and non-susceptible S. aureus isolates was determined from two global Phase 3 studies of delafloxacin versus vancomycin plus aztreonam in ABSSSI. Patients were enrolled in 23 countries predominately in the US but also Eastern Europe, South America and Asia...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28619639/chitosan-doped-with-nanoparticles-of-copper-nickel-and-cobalt
#2
Galo Cárdenas-Triviño, Carolina Elgueta, Luis Vergara, Javier Ojeda, Ariel Valenzuela, Christian Cruzat
Metal colloids in 2 propanol using nanoparticles (NPs) of copper, nickel and cobalt were prepared by Chemical Liquid Deposition (CLD) method. The resulting colloidal dispersions were characterized by Transmission Electron Microscopy (TEM). The colloids were supported in chitosan. Then, microbiological assays were performed using E. coli and S. aureus in order to determine the bactericide/bacteriostatic activity of nanoparticles (NPs) trapped or chelated with chitosan. Finally, the toxicity of the metal colloids Cu, Ni and Co was tested...
June 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28603564/a-study-on-the-microbiological-status-of-mineral-drinking-water
#3
Faria Y Aditi, Shafkat S Rahman, Md M Hossain
INTRODUCTION: Water-borne diseases constitute a major health burden in Bangladesh. The objective of this study was to assess the overall quality of mineral water samples that obtained from different shops of Dhaka city. MATERIAL AND METHODS: To achieve the above-mentioned objective, methods of heterotrophic plate count (HPC) and total coliform count (TCC) were applied. Moreover, isolated colony from mineral water samples were characterized by using biochemical and antimicrobial susceptibility tests...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/28587631/bacterial-etiologic-agents-causing-neonatal-sepsis-and-associated-risk-factors-in-gondar-northwest-ethiopia
#4
Tsehaynesh G/Eyesus, Feleke Moges, Setegn Eshetie, Biruk Yeshitela, Ebba Abate
BACKGROUND: Neonatal sepsis is a blood stream infection which is seen in the first month of life of the neonate. Bacterial profile of neonatal septicemia is constantly changing thus, current knowledge on the patterns of bacterial isolates, its antibiotic resistance profile, and associated factors, are essential to design and implement appropriate interventions. Therefore, the aim of this study was to identify bacterial etiologic agents, their antimicrobial susceptibility pattern and associated risk factors of neonatal sepsis among neonates...
June 6, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28575367/colonization-density-of-the-upper-respiratory-tract-as-a-predictor-of-pneumonia-haemophilus-influenzae-moraxella-catarrhalis-staphylococcus-aureus-and-pneumocystis-jirovecii
#5
Daniel E Park, Henry C Baggett, Stephen R C Howie, Qiyuan Shi, Nora L Watson, W Abdullah Brooks, Maria Deloria Knoll, Laura L Hammitt, Karen L Kotloff, Orin S Levine, Shabir A Madhi, David R Murdoch, Katherine L O'Brien, J Anthony G Scott, Donald M Thea, Dilruba Ahmed, Martin Antonio, Vicky L Baillie, Andrea N DeLuca, Amanda J Driscoll, Wei Fu, Caroline W Gitahi, Emmanuel Olutunde, Melissa M Higdon, Lokman Hossain, Ruth A Karron, Abdoul Aziz Maiga, Susan A Maloney, David P Moore, Susan C Morpeth, John Mwaba, Musaku Mwenechanya, Christine Prosperi, Mamadou Sylla, Somsak Thamthitiwat, Scott L Zeger, Daniel R Feikin
Background.: There is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. We assessed this association for Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. Methods.: In 7 low- and middle-income countries, nasopharyngeal/oropharyngeal swabs from children with severe pneumonia and age-frequency matched community controls were tested using quantitative polymerase chain reaction (PCR)...
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28559740/the-anti-staphylococcus-aureus-effect-of-combined-echinophora-platyloba-essential-oil-and-liquid-smoke-in-beef
#6
Zahra Pilevar, Hedayat Hosseini, Homa Hajimehdipoor, Farzaneh Shahraz, Leyla Alizadeh, Amin Mousavi Khaneghah, Maryam Mahmoudzadeh
In the current study, the antibacterial effect of Echinophora platyloba essential oil and common liquid smoke (individually and in combination) against Staphylococcus aureus in beef meat samples is investigated. Using an automated microbiological growth analyser and the turbidimetric technique, the minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the essential oil and liquid smoke were determined. Anti-S. aureus activity of essential oil and liquid smoke (individually and in combination) was defined by disk diffusion assay, generation time and cell constituent release...
March 2017: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/28545485/bacteriological-etiology-and-treatment-of-mastitis-in-finnish-dairy-herds
#7
Johanna Vakkamäki, Suvi Taponen, Anna-Maija Heikkilä, Satu Pyörälä
BACKGROUND: The Finnish dairy herd recording system maintains production and health records of cows and herds. Veterinarians and farmers register veterinary treatments in the system. Milk samples for microbiological analysis are routinely taken from mastitic cows. The laboratory of the largest dairy company in Finland, Valio Ltd., analyzes most samples using real-time PCR. This study addressed pathogen-specific microbiological data and treatment and culling records, in combination with cow and herd characteristics, from the Finnish dairy herd recording system during 2010-2012...
May 25, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28542534/the-carriage-of-interleukin-1b-31-c-allele-plus-staphylococcus-aureus-and-haemophilus-influenzae-increases-the-risk-of-recurrent-tonsillitis-in-a-mexican-population
#8
Baltazar González-Andrade, Ramiro Santos-Lartigue, Samantha Flores-Treviño, Natalie Sonia Ramirez-Ochoa, Paola Bocanegra-Ibarias, Francisco J Huerta-Torres, Soraya Mendoza-Olazarán, Licet Villarreal-Treviño, Adrián Camacho-Ortiz, Hipólito Villarreal-Vázquez, Elvira Garza-González
The aim of the present study was to estimate the relative contribution of immunogenetic and microbiological factors in the development of recurrent tonsillitis in a Mexican population. Patients (n = 138) with recurrent tonsillitis and an indication of tonsillectomy (mean age: 6.05 years ± 3.00; median age: 5 years, female: 58; age range: 1-15 years) and 195 non-related controls older than 18 years and a medical history free of recurrent tonsillitis were included. To evaluate the microbial contribution, tonsil swab samples from both groups and extracted tonsil samples from cases were cultured...
2017: PloS One
https://www.readbyqxmd.com/read/28540152/epidemiological-clinical-and-microbiological-characteristics-of-patients-with-post-traumatic-osteomyelitis-of-limb-fractures-in-southwest-china-a-hospital-based-study
#9
Jiachen Peng, Youliang Ren, Wenbin He, Zhengdao Li, Jin Yang, Yi Liu, Zhonghui Zheng, Stephen L Kates, Edward M Schwarz, Chao Xie, Youjia Xu
Objective To determine the epidemiological, clinical and microbiological characteristics, of patients with post-traumatic osteomyelitis of extremity fractures, and provide evidence-based guidelines for early diagnosis and treatment, including empiric antibiotic therapy. Methods Human subject research was performed using institutional review board approved protocols. A retrospective chart review was conducted on 5,368 patients diagnosed with extremity traumatic fractures from January 1, 2012 to December 31, 2015, to identify osteomyelitis patients...
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28525941/environmental-contamination-with-staphylococcus-aureus-at-a-large-midwestern-university-campus
#10
Dipendra Thapaliya, Mohammed Taha, Mark R Dalman, Jhalka Kadariya, Tara C Smith
BACKGROUND: Staphylococcus aureus can cause minor to severe life-threatening infections. The changing epidemiology of S. aureus is of public health concern due to the emergence of multi-drug resistant (MDR) strains. Environmental surfaces play a crucial role in the transmission of S. aureus. The objective of this study was to examine environmental contamination and molecular characteristics of S. aureus in health professional-associated (HPA) and non-health professional-associated (NHPA) buildings at a large university...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28515650/prevalence-and-comparing-of-some-microbiological-properties-somatic-cell-count-and-antibiotic-residue-of-organic-and-conventional-raw-milk-produced-in-turkey
#11
Bayram Ürkek, Mustafa Şengül, Tuba Erkaya, Vecihi Aksakal
The aim of this study was to investigate the effects of production systems and milk collection periods on the somatic cell count (SCC), some microbiological properties, total aerobic mesophilic bacteria (TAMB), coliform, Staphylococcus aureus (S. aureus), yeast and mould) and antibiotic residue of milk; in Turkey. Milk samples were collected from 9 conventional farms and 9 organic farms during one year time, at six different months (December 2013 to October 2014), and all farms were selected from the same geographical locations...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28496492/infective-endocarditis-report-from-a-main-referral-teaching-hospital-in-iran
#12
Behrooz Heydari, Iman Karimzadeh, Hossein Khalili, Esfandiar Shojaei, Abdolrasool Ebrahimi
BACKGROUND/OBJECTIVE: The aim of the present preliminary study was to assess the demographic, clinical, paraclinical, microbiological, echocardiographic, and therapeutic profile as well as in-hospital outcome of patients with infective endocarditis at a referral center for various infectious diseases in Iran. METHODS: Required demographic, clinical, plausible complications and paraclinical data were collected from patients' medical charts. Echocardiographic findings were obtained by performing transthoracic and/or transesophageal echocardiography as clinically indicated...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28492525/neonatal-sepsis-in-rural-india-timing-microbiology-and-antibiotic-resistance-in-a-population-based-prospective-study-in-the-community-setting
#13
P Panigrahi, D S Chandel, N I Hansen, N Sharma, S Kandefer, S Parida, R Satpathy, L Pradhan, A Mohapatra, S S Mohapatra, P R Misra, N Banaji, J A Johnson, J G Morris, I H Gewolb, R Chaudhry
OBJECTIVE: To examine the timing and microbiology of neonatal sepsis in a population-based surveillance in the Indian community setting. STUDY DESIGN: All live born infants in 223 villages of Odisha state were followed at home for 60 days. Suspect sepsis cases were referred to study hospitals for further evaluation including blood culture. RESULTS: Of 12 622 births, 842 were admitted with suspected sepsis of whom 95% were 4 to 60 days old...
May 11, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28485357/bacteriological-trends-and-antibiotic-susceptibility-patterns-of-clinical-isolates-at-government-cancer-hospital-marathwada
#14
S Nazneen, K Mukta, C Santosh, A Borde
INTRODUCTION: Preventing and starting early treatment of infections in patients whose immunity system is weak due to malignancies can reduce mortality. Since our hospital is a newly constructed one, this study aimed to determine microbial and antibiotic resistance patterns in clinical samples of patients with cancer at our center to start early treatment before the results of clinical tests are known. SUBJECTS AND METHODS: The study was carried out in the Department of Microbiology, Government Cancer Hospital during the period from January 2016 to December 2016...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28482491/influence-of-antibody-immobilization-strategies-on-the-analytical-performance-of-a-magneto-elastic-immunosensor-for-staphylococcus-aureus-detection
#15
C Menti, M Beltrami, M D Pozza, S T Martins, J A P Henriques, A D Santos, F P Missell, M Roesch-Ely
Magneto-elastic (ME) sensors have a great advantage in microbiology due to their ability to be queried wirelessly. Staphylococcus aureus is one of the most common bacteria widespread in the environment and a major human pathogen related to numerous illnesses. Immunosensors are affinity-based assays where the analyte is highly selective. The immobilization of antibodies (Ab) is an important step in the development of such devices. This study compared the effects of two antibody immobilization strategies on the analytical performance of a magneto-elastic immunosensor: (1) random antibody covalent immobilization (CysAb) and (2) specific-oriented antibody covalent immobilization (PrGAb)...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28476559/infection-with-enterotoxigenic-staphylococcus-aureus-as-a-concern-in-patients-with-gastroenteritis
#16
Masoumeh Azimirad, Anahita Dezfulian, Masoud Alebouyeh, Rasoul Bahreiny Esfehani, Shabnam Shahrokh, Mohammad Reza Zali
OBJECTIVES: Intestinal overgrowth of Staphylococcus aureus may promote unpleasant disorders in the human intestinal tract. This study assessed the prevalence of enterotoxigenic multidrug-resistant S. aureus (MDR-SA) in patients with gastroenteritis. METHODS: Microbiological analysis of 345 faecal samples from patients with gastroenteritis was performed to detect infection with S. aureus in the absence of common enteric pathogens. Methicillin-resistant S. aureus (MRSA) was characterised by the cefoxitin disk diffusion method...
June 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28475974/ultraviolet-ultrasound-activated-persulfate-for-degradation-of-drug-by-zinc-selenide-quantum-dots-catalysis-and-microbiology-study
#17
Ali Fakhri, Mahsa Naji, Shiva Tahami
In this study, wet chemical method used for ZnSe quantum dots (QDs) and characterized by, UV-vis, photoluminescence spectroscopy, X-ray diffraction and transmission electron microscopy. The crystallites size of ZnSe QDs was 4.0nm. The average diameters of ZnSe QDs were 3.0-5.3nm. Ritalin was degraded using the UV/ZnSe QDs/persulfate process. The several parameters investigated for the influence of Rtialin degradation were the temperature, the persulfate concentration, and the initial Ritalin concentration. The values of optimum parameters ware room temperature, concentration persulfate 5mmol/L and initial Ritalin concentration 0...
May 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28474179/evaluation-of-sampling-locations-in-pregnant-women-and-newborns-for-the-detection-of-colonisation-with-antibiotic-resistant-bacteria
#18
M Zamfir, A C Adler, S Kolb, A Dammeyer, L Nasri, L Schomacher, B Karlin, M Franitza, S Hörmansdorfer, C Tuschak, G Valenza, U Ochmann, C Herr
Up to now, little has been known about the prevalence and clinical relevance of colonisation of asymptomatic pregnant women with methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA) or extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. In this two-centre cross-sectional study, we evaluated the performance and importance of screening at different times and different locations for colonisation in pregnant women and newborns. Between October 2013 and December 2015, four samples were collected from pregnant women, two from newborns at birth and three from 3-day-old newborns...
May 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28471400/epidemiology-and-management-of-acute-haematogenous-osteomyelitis-in-a-tertiary-paediatric-center
#19
Elena Chiappini, Caterina Camposampiero, Simone Lazzeri, Giuseppe Indolfi, Maurizio De Martino, Luisa Galli
Background: Paediatric acute hematogenous osteomyelitis (AHOM) is a serious disease requiring early diagnosis and treatment. To review the clinical presentation, management and organisms responsible for AHOM, and to explore risk factors for complicated AHOM, a large cohort referring to a single center over a 6-year period was evaluated. Methods: Data from children with AHOM, hospitalized between 2010 and 2015, and aged > 1 month, were retrospectively collected and analyzed. Results: 121 children (median age 4...
May 4, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28470080/genetic-characterisation-of-antimicrobial-resistance-and-virulence-genes-in-i-staphylococcus-aureus-i-isolated-from-commercial-broiler-chickens-in-the-durban-metropolitan-area-south-africa
#20
Nelisiwe Mkize, Oliver T Zishiri, Samson Mukaratirwa
Antimicrobial resistance of Staphylococcus aureus in human and veterinary medicine is a serious worldwide problem. The aim of this study was to investigate the prevalence of S. aureus in commercial broiler chickens as well as to establish antimicrobial susceptibility and the distribution of genetic determinants conferring resistance and virulence. One hundred and ninety-four samples were aseptically collected from broiler chicken slaughterhouses and retail outlets around the Durban metropolitan area in South Africa...
May 4, 2017: Journal of the South African Veterinary Association
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