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Lamina Cribrosa

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https://www.readbyqxmd.com/read/28528864/effects-of-collagen-microstructure-and-material-properties-on-the-deformation-of-the-neural-tissues-of-the-lamina-cribrosa
#1
A P Voorhees, N-J Jan, I A Sigal
It is widely considered that intraocular pressure (IOP)-induced deformation within the neural tissue pores of the lamina cribrosa (LC) contributes to neurodegeneration and glaucoma. Our goal was to study how the LC microstructure and mechanical properties determine the mechanical insult to the neural tissues within the pores of the LC. Polarized light microscopy was used to measure the collagen density and orientation in histology sections of three sheep optic nerve heads (ONH) at both mesoscale (4.4 μm) and microscale (0...
May 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28494490/biomechanical-responses-of-lamina-cribrosa-to-intraocular-pressure-change-assessed-by-optical-coherence-tomography-in-glaucoma-eyes
#2
Harry Quigley, Karun Arora, Sana Idrees, Francisco Solano, Sahar Bedrood, Christopher Lee, Joan Jefferys, Thao Nguyen
Purpose: The purpose of this study was to measure change in anterior lamina cribrosa depth (ALD) globally and regionally in glaucoma eyes at different intraocular pressures (IOP). Methods: Twenty-seven glaucoma patients were imaged before and after IOP-lowering procedures using optical coherence tomography. The anterior lamina was marked in approximately 25 locations in each of six radial scans to obtain global and regional estimates of ALD. ALD and its change with IOP were compared with optic disc damage, nerve fiber layer thickness, and visual field loss...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28486274/a-novel-method-for-assessing-lamina-cribrosa-structure-ex-vivo-using-anterior-segment-enhanced-depth-imaging-optical-coherence-tomography
#3
Jason L Chien, Mark P Ghassibi, Pooja Mahadeshwar, Pengcheng Li, Jeffrey M Liebmann, Robert Ritch, Tatyana Milman, Sung Chul Park
PURPOSE: The purpose of this study is to investigate the use of anterior segment enhanced depth imaging (EDI) optical coherence tomography (OCT) for ex vivo lamina cribrosa (LC) imaging. MATERIALS AND METHODS: After removing anterior segment and vitreous, the optic nerve head (ONH) tissue of porcine eyes was placed on a customized eye holder for imaging. Serial EDI OCT B-scans (interval, ∼35 μm) of the ONH were obtained using anterior segment module of spectral-domain OCT...
May 8, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28461018/serial-changes-in-lamina-cribrosa-depth-and-neuroretinal-parameters-in-glaucoma-impact-of-choroidal-thickness
#4
Jayme R Vianna, Victoria R Lanoe, Jack Quach, Glen P Sharpe, Donna M Hutchison, Anne C Belliveau, Lesya M Shuba, Marcelo T Nicolela, Balwantray C Chauhan
PURPOSE: To determine whether: (1) change in lamina cribrosa depth occurs more frequently than change in neuroretinal parameters in glaucoma, and (2) Bruch's membrane or anterior sclera should be used as a reference plane when measuring laminar depth. DESIGN: Prospective observational study. PARTICIPANTS: One hundred fifty-five glaucoma patients and 35 healthy controls. METHODS: Anterior laminar depth from a Bruch's membrane (LD-BM) or anterior sclera (LD-AS) reference plane were measured with optical coherence tomography...
April 28, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28446148/circumpapillary-retinal-nerve-fiber-layer-thickness-anterior-lamina-cribrosa-depth-and-lamina-cribrosa-thickness-in-neovascular-glaucoma-secondary-to-proliferative-diabetic-retinopathy-a-cross-sectional-study
#5
Satoshi Yokota, Yuji Takihara, Yoshihiro Takamura, Masaru Inatani
BACKGROUND: To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography. METHODS: Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups...
April 26, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28430332/relationship-between-corneal-biomechanical-properties-and-optic-nerve-head-changes-after-deep-sclerectomy
#6
Laura Díez-Álvarez, Francisco J Muñoz-Negrete, Pilar Casas-Llera, Noelia Oblanca, Victoria de Juan, Gema Rebolleda
PURPOSE: To evaluate corneal biomechanical properties and optic nerve head (ONH) changes following deep sclerectomy (DS) and the relation to each other. METHODS: Forty-nine eyes with primary open-angle glaucoma that underwent DS were studied. Corneal biomechanical properties were assessed using the Ocular Response Analyzer and the ONH was evaluated by Spectralis optical coherence tomography with enhanced depth imaging technology before surgery and 3 months postoperatively...
April 4, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28391369/relationship-between-lamina-cribrosa-displacement-and-trans-laminar-pressure-difference-in-papilledema
#7
Javier García-Montesinos, Francisco J Muñoz-Negrete, Victoria de Juan, Gema Rebolleda
PURPOSE: The purpose of this study was to describe morphological changes in lamina cribrosa (LC), prelaminar tissue thickness (PTT) and Bruch's membrane opening (BMO) in eyes affected by papilledema and correlate them with trans-LC-pressure difference (TLCD). METHODS: This was a prospective study, including twelve eyes newly diagnosed of papilledema. Eyes underwent scanning with Spectralis-OCT with enhanced depth imaging to compare BMO, anterior LC surface position (LC depth-LCD-) and PTT before and after oedema resolution...
April 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28389675/deformation-of-the-lamina-cribrosa-and-optic-nerve-due-to-changes-in-cerebrospinal-fluid-pressure
#8
Andrew J Feola, Baptiste Coudrillier, John Mulvihill, Diogo M Geraldes, Nghia T Vo, Julie Albon, Richard L Abel, Brian C Samuels, C Ross Ethier
Purpose: Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28383403/influence-of-the-lamina-cribrosa-on-the-rate-of-global-and-localized-retinal-nerve-fiber-layer-thinning-in-open-angle-glaucoma
#9
Hae-Young Lopilly Park, Sung In Kim, Chan Kee Park
The advent of optical coherence tomography (OCT) imaging allows identification of the structural contribution of the lamina cribrosa (LC) to glaucoma progression. This study aimed to determine the role of various LC features, such as the LC depth (LCD), LC thickness (LCT), and focal LC defects, on the future rate of progressive retinal nerve fiber layer (RNFL) thinning in patients with glaucoma. One hundred eighteen patients with glaucoma who had undergone at least 4 OCT examinations were included. Features of LC, including the LCD, LCT, and presence of focal LC defects, from serial scan of the optic disc using the enhanced depth imaging of Spectralis OCT; were analyzed at baseline...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28353690/impact-of-rates-of-change-of-lamina-cribrosa-and-optic-nerve-head-surface-depths-on-visual-field-progression-in-glaucoma
#10
Zhongheng Wu, Chen Lin, Michael Crowther, Heather Mak, Marco Yu, Christopher K-S Leung
Purpose: To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma. Methods: One hundred forty-six eyes of 95 glaucoma patients had optical coherence tomography ONH imaging and VF testing at approximately 4-month intervals for greater than or equal to 5 years. Anterior lamina cribrosa surface depth and ONHSD were measured with reference to (1) Bruch's membrane opening (BMO), and (2) choroid-sclera interface (CSI)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28324116/thick-prelaminar-tissue-decreases-lamina-cribrosa-visibility
#11
Katie A Lucy, Bo Wang, Joel S Schuman, Richard A Bilonick, Yun Ling, Larry Kagemann, Ian A Sigal, Ireneusz Grulkowski, Jonathan J Liu, James G Fujimoto, Hiroshi Ishikawa, Gadi Wollstein
Purpose: Evaluation of the effect of prelaminar tissue thickness on visualization of the lamina cribrosa (LC) using optical coherence tomography (OCT). Methods: The optic nerve head (ONH) region was scanned using OCT. The quality of visible LC microstructure was assessed subjectively using a grading system and objectively by analyzing the signal intensity of each scan's superpixel components. Manual delineations were made separately and in 3-dimensions quantifying prelaminar tissue thickness, analyzable regions of LC microstructure, and regions with a visible anterior LC (ALC) boundary...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28323178/study-on-the-deformations-of-the-lamina-cribrosa-during-glaucoma
#12
Hanjing Tian, Long Li, Fan Song
The lamina cribrosa is the primary site of optic nerve injury during glaucoma, and its deformations induced by elevated intraocular pressure are associated directly with the optic nerve injury and visual field defect. However, the deformations in a living body have been poorly understood yet so far. It is because that integral observation and precise measurement of the deformations in vivo are now almost impossible in the clinical diagnosis and treatment of glaucoma. In the present study, a new mechanical model of the lamina cribrosa is presented by using Reissner's thin plate theory...
March 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28260366/-application-value-of-corneal-hysteresis-in-diagnosis-and-treatment-of-glaucoma
#13
L Y He, L Liang, M N Zhu
Glaucoma is the first leading cause of irreversible blindness world widely, but the pathogenesis was still unclear. The collagen fibers from cornea and sclera connect to each other and both of them have similar extracellular matrix components. The biomechanical characteristics of optic nerve lamina cribrosa may associated with the biomechanical properties of the cornea. Therefore, the study of corneal physiological can indirectly reflex the compression and damage in optic nerve lamina cribrosa. The technical developments in corneal hysteresis examination had been updated these years constantly...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28252388/three-dimensional-segmentation-of-the-ex-vivo-anterior-lamina-cribrosa-from-second-harmonic-imaging-microscopy
#14
Sundaresh Ram, Forest Danford, Stephen Howerton, Jeffrey Rodriguez, Jonathan Vande Geest
The lamina cribrosa (LC) 1 is a connective tissue in the posterior eye with a complex mesh-like trabecular microstructure through which all the retinal ganglion cell axons and central retinal vessels pass. Recent studies have demonstrated that changes in the structure of the LC correlate with glaucomatous damage. Thus, accurate segmentation and reconstruction of the LC is of utmost importance. This paper presents a new automated method for segmenting the microstructure of the anterior LC in the images obtained via multiphoton microscopy using a combination of ideas...
February 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28251093/enhanced-depth-oct-imaging-of-the-lamina-cribrosa-for-24-hours
#15
Pedro Naranjo-Bonilla, Rafael Giménez-Gómez, David Ríos-Jiménez, María Luísa Varas-Fabra, María Del Carmen Muñoz-Villanueva, Rocío García-Catalán, Pilar Font-Ugalde, María Soledad Poblador-Fernández, José Luís Lancho-Alonso, José María Gallardo-Galera
The lamina cribrosa thickness (LCT) could be affected by dynamic changes in its structure. Using Spectral-domain-optical coherence tomography (SD-OCT), we have studied the behaviour of the laminar region in 14 young subjects over 24h. Significant changes in LCT were observed, depending on the time at which the measurement was taken, with the maximum thickness being observed at 7.30 p.m., and the minimum at 7.30 a.m. This finding could suggests a circadian pattern in the LCT thickness in healthy subjects, which could have implications for the classification, diagnosis and prognosis of both normal and glaucomatous subjects...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28223179/biological-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#16
REVIEW
Ernst R Tamm, C Ross Ethier
Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced axonal damage in glaucoma is at the optic nerve head (ONH). However, the mechanisms that cause IOP-induced damage at the ONH are far from understood. A possible sequence of events could originate with IOP-induced stress in the ONH connective tissue elements (peripapillary sclera, scleral canal and lamina cribrosa) that leads to an increase in biomechanical strain...
February 20, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28221329/relationship-between-anterior-lamina-cribrosa-surface-tilt-and-glaucoma-development-in-myopic-eyes
#17
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To evaluate the anterior lamina cribrosa (LC) surface tilt angle in myopic eyes and associate it with glaucoma development. MATERIALS AND METHODS: In this retrospective study, medical records of myopic patients referred for glaucoma examination from July 1, 2012 to March 30, 2016 were reviewed. Comprehensive ophthalmic examination including spectral-domain optical coherence tomography were performed. We measured the angle of anterior LC surface tilt against Bruch's membrane opening from optical coherence tomography images at the center of the clinical optic disc margin...
May 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28197790/surgical-treatment-of-anterior-cranial-fossa-dural-arterio-venous-fistulas-davfs-a-two-centre-experience
#18
Pietro Meneghelli, Alberto Pasqualin, Luigi Andrea Lanterna, Claudio Bernucci, Roberto Spinelli, Gianluigi Dorelli, Piergiuseppe Zampieri
BACKGROUND: Anterior cranial fossa dural arterio-venous fistulas (DAVFs) represent 6% of all intracranial DAVFs; characteristically they show an aggressive behaviour with high risk of intracranial haemorrhage. Peculiar anatomical features, such as feeding by the ethmoidal arteries and the pattern of venous drainage (frequently with varices that mimic aneurysmal dilatation), can be evaluated in detail only by digital subtraction angiography (DSA), which represents the "gold standard" in the diagnosis of such cranial fistulas...
May 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28174676/a-digital-staining-algorithm-for-optical-coherence-tomography-images-of-the-optic-nerve-head
#19
Jean-Martial Mari, Tin Aung, Ching-Yu Cheng, Nicholas G Strouthidis, Michaël J A Girard
PURPOSE: To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. METHODS: OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28168044/anti-inflammatory-and-antioxidative-stress-effects-of-oryzanol-in-glaucomatous-rabbits
#20
Shital S Panchal, Rajesh K Patidar, Abhishek B Jha, Ahmed A Allam, Jamaan Ajarem, Shital B Butani
Purpose. γ-Oryzanol works by anti-inflammatory and radical scavenging activity as a neuroprotective, anticancer, antiulcer, and immunosuppressive agent. The present study was conducted to investigate effect of oryzanol in acute and chronic experimental glaucoma in rabbits. Methods. Effect of oryzanol was evaluated in 5% dextrose induced acute model of ocular hypertension in rabbit eye. Chronic model of glaucoma was induced with subconjunctival injection of 5% of 0.3 ml phenol. Treatment with oryzanol was given for next two weeks after induction of glaucoma...
2017: Journal of Ophthalmology
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