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Lamina Cribrosa

Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
Youngkyo Kwun, Gyule Han, Yoon-Jung Choy, Jong Chul Han, Changwon Kee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the optic disc characteristics associated with visual field (VF) progression in normal tension glaucoma (NTG) eyes with tilted optic discs. METHODS: Sixty-six eyes of 66 NTG patients with tilted optic disc were included in this cross-sectional study, who were examined by at least 5 Humphrey 30-2 VFs. Glaucomatous VF progression was evaluated using pointwise linear regression. Optic nerve heads were scanned with enhanced-depth imaging optical coherence tomography (EDI-OCT), and evaluated for the focal lamina cribrosa (LC) defects and LC thicknesses...
October 14, 2016: Journal of Glaucoma
Andrew Koustenis, Alon Harris, Josh Gross, Ingrida Januleviciene, Aaditya Shah, Brent Siesky
In recent years, ophthalmology has experienced significant developments with respect to imaging modalities. Optical coherence tomography angiography is one such technology that seeks to improve diagnostics for retinal diseases. Using standard structural ocular coherence tomography hardware, optical coherence tomography angiography demonstrates the ability to non-invasively visualise the vasculature in the retina and the choroid with high resolution, allowing greater insight into retinal vascular pathologies...
October 4, 2016: British Journal of Ophthalmology
Kumar Sambhav, Sandeep Grover, K V Chalam
PURPOSE: Swept Source Optical Coherence Tomography validates lamina cribrosa anomaly in optic disk pit. METHOD: Observational case report. RESULTS: A 25-year-old African American male presented with decreased vision in right eye of 4 days duration. Best corrected visual acuity (BCVA) for distance in right eye was 20/200 and in left eye was 20/20. Dilated fundus examination of right eye showed serous macular detachment of entire posterior pole along with an optic pit on temporal margin of optic disk...
September 22, 2016: Retinal Cases & Brief Reports
David Cordeiro Sousa, Inês Leal, Carlos Marques-Neves, Filomena Pinto, Luís Abegão Pinto
PURPOSE: To investigate the association between anterior lamina cribrosa depth (ALCD), determined with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), and intraocular pressure (IOP) in a healthy Portuguese population. METHODS: In this cross-sectional observational study conducted between January and July 2015, 2 optic nerve head (ONH)-centered EDI-OCT cross-scans were performed and ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa at the maximum depth point...
September 13, 2016: European Journal of Ophthalmology
Francisco Pérez Bartolomé, Jose María Martínez de la Casa, Irene Camacho Bosca, Federico Sáenz-Francés, Soledad Aguilar Munoa, Alberto Martín Juan, Julian Garcia-Feijoo
PURPOSE: To examine interrelations between corneal biomechanics, ocular biometric variables and optic disc size (ODS), lamina cribosa depth (LCD) or thickness (LCT) in a healthy population. MATERIAL AND METHODS: In a cross-sectional case-control study, the following measurements were made in 81 eyes of 81 participants: axial length, anterior chamber depth, lens thickness, and central corneal thickness using the optical biometer Lenstar LS900; and corneal hysteresis (CH), corneal resistance factor (CRF), Goldman-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) using the Ocular Response Analyzer...
September 14, 2016: Seminars in Ophthalmology
Yengwoo Son, Seungwoo Lee, Jongyeop Park
PURPOSE: Thinning of the lamina cribrosa thickness (LCT) and prelaminar tissue thickness (PT) has been observed in patients with glaucoma, and branch retinal vein occlusion (BRVO) is reportedly related to glaucoma. To test the hypothesis that thinning of the LCT and PT occurs in patients with BRVO, we investigated possible correlations of the LCT and PT in BRVO-affected eyes and fellow eyes and compared these values with age-, sex-, and underlying disease-matched eyes. METHOD: The study included 50 patients (50 eyes) with unilateral BRVO and 35 control subjects (35 eyes)...
September 14, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Mehmet Giray Ersoz, Duygu Kunak Mart, Emre Ayintap, Leyla Hazar, Irfan Botan Gunes, Seda Karaca Adiyeke, Beysim Dogan
PURPOSE: To investigate whether there is a difference between primary open-angle glaucoma (POAG) patients and control group with regard to choroidal thickness (CT) and the factors influencing CT. METHODS: Ninety eyes of 90 patients who were being followed up with POAG and 72 eyes of 72 healthy subjects matched for age and gender were included. Peripapillary retinal nerve fiber layer thickness (RNFLT), peripapillary CT, lamina cribrosa thickness (LCT), and prelaminar tissue thickness (PTT) were measured with spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI) in all patients...
September 12, 2016: International Ophthalmology
Yong Woo Kim, Jin Wook Jeoung, Michael J A Girard, Jean Martial Mari, Ki Ho Park
PURPOSE: To investigate the variation of lamina cribrosa (LC) structure based on the baseline intraocular pressure (IOP) in eyes with primary open-angle glaucoma (POAG) and healthy individuals using swept-source optical coherence tomography. METHODS: A total of 108 eyes with POAG and 61 healthy eyes were recruited. Based on the baseline IOP, the POAG eyes were divided into higher-baseline IOP (HTG; baseline IOP > 21 mmHg, n = 38 eyes) and lower-baseline IOP (NTG; baseline IOP ≤ 21 mmHg, n = 70 eyes)...
2016: PloS One
Masoud Aghsaei Fard, Marjan Afzali, Parisa Abdi, Rebecca Chen, Mehdi Yaseri, Ebrahim Azaripour, Sasan Moghimi
PURPOSE: To compare optic nerve head (ONH) morphology of optic nerve atrophy between eyes with primary open-angle glaucoma (POAG) and eyes with a history of nonarteritic anterior ischemic optic atrophy (NAION) using enhanced depth imaging (EDI) with spectral-domain optical coherence tomography (SD-OCT). METHODS: In this cross-sectional study, 121 eyes of 91 patients consisted of moderate to severe POAG (n = 32 eyes), visual field mean deviation-matched NAION (n = 30 eyes) and their fellow eyes (n = 30 eyes), and healthy controls (n = 29)...
September 1, 2016: Investigative Ophthalmology & Visual Science
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Siamak Yousefi, Robert N Weinreb
PURPOSE: To investigate whether vessel density assessed by optical coherence tomography angiography (OCT-A) is reduced in glaucomatous eyes with focal lamina cribrosa (LC) defects. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: A total of 82 patients with primary open-angle glaucoma (POAG) from the Diagnostic Innovations in Glaucoma Study (DIGS) with and without focal LC defects (41 eyes of 41 patients in each group) matched by severity of visual field (VF) damage...
August 31, 2016: Ophthalmology
Jayter S Paula, Colm O'Brien, W Daniel Stamer
Primary open-angle glaucoma is a multifactorial blinding disease often impacting the two pressure-sensitive regions of the eye: the conventional outflow pathway and the optic nerve head (ONH). The connective tissues that span these two openings in the globe are the trabecular meshwork of the conventional outflow pathway and the lamina cribrosa of the ONH. Resident cribiform cells of these two regions are responsible for actively remodeling and maintaining their connective tissues. In glaucoma, aberrant maintenance of the juxtacanalicular tissues (JCT) of the conventional outflow pathway results in ocular hypertension and pathological remodeling of the lamina cribrosa results in ONH cupping, damaging retinal ganglion cell axons...
October 2016: Experimental Eye Research
Vincent Kyu Lee, Raffaele Nardone, Fern Wasco, Ashok Panigrahy, Giulio Zuccoli
BACKGROUND: Functional magnetic resonance imaging may help in elucidating the pathophysiology of post-traumatic anosmia. METHOD: Using an fMRI olfactory stimulus paradigm, this study compared BOLD activation of the brain in a 21-year old male research subject with post-traumatic anosmia and a 19-year old male normal healthy control participant. OUTCOMES: A delayed activation of the primary orbitofrontal cortex was found in the subject with traumatic anosmia, which may represent a crucial pathophysiological mechanism in the subject with traumatic anosmia due to axonal injury or traumatic transection at the lamina cribrosa level...
August 26, 2016: Brain Injury: [BI]
Ben Mead, Stanislav Tomarev
Retinal ganglion cells (RGC) bear the sole responsibility of propagating visual stimuli to the brain. Their axons, which make up the optic nerve, project from the retina to the brain through the lamina cribrosa and in rodents, decussate almost entirely at the optic chiasm before synapsing at the superior colliculus. For many traumatic and degenerative ocular conditions, the dysfunction and/or loss of RGC is the primary determinant of visual loss and are the measurable endpoints in current research into experimental therapies...
October 2016: Experimental Eye Research
Su-Ho Lim, Mirae Kim, Woohyok Chang, Min Sagong
PURPOSE: To compare the lamina cribrosa (LC) thickness of healthy subjects and patients with unilateral branch retinal vein occlusion (BRVO), and to determine possible correlations between the LC thickness and the BRVO subtypes. METHODS: This prospective, cross-sectional study included a total of 46 patients with naive, untreated, unilateral BRVO and 31 healthy control subjects. The occlusion site was divided into two BRVO types: arteriovenous crossing BRVO (AV-BRVO) and optic nerve BRVO (ON-BRVO)...
July 12, 2016: Retina
Jae Hyung Lee, Hae-Young Lopilly Park, Jiwon Baek, Won Ki Lee
PURPOSE: To describe the findings of enhanced depth imaging (EDI) optical coherence tomography (OCT) of the lamina cribrosa (LC) in glaucoma and pachychoroid spectrum diseases associated with peripapillary retinoschisis. DESIGN: Retrospective, observational case series. PARTICIPANTS: A total of 16 patients from 1 institution. METHODS: Detailed medical case histories, optic disc and retinal imaging with EDI using the Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany), and clinical course were reviewed for patients with peripapillary retinoschisis without a known predisposing condition...
October 2016: Ophthalmology
Aitor Lanzagorta-Aresti, Marta Perez-Lopez, Elena Palacios-Pozo, Juan Davo-Cabrera
PURPOSE: To evaluate the relationship between the displacement of the lamina cribrosa (LC) and prelaminar tissue with corneal hysteresis (CH) using spectral-domain coherence tomography (SD-OCT) after reducing intraocular pressure (IOP) with medical treatment. METHODS: Sixty-one eyes of 61 patients with ocular hypertension or primary open-angle glaucoma who were going to start with treatment were imaged by means of 12 cross-sectional scans of the optic nerve using enhanced depth imaging SD-OCT before and after 1 week of treatment...
July 29, 2016: British Journal of Ophthalmology
Mary Ann Croft, Elke Lütjen-Drecoll, Paul L Kaufman
The ciliary muscle plays a major role in controlling both accommodation and outflow facility in primates. The ciliary muscle and the choroid functionally form an elastic network that extends from the trabecular meshwork all the way to the back of the eye and ultimately attaches to the elastic fiber ring that surrounds the optic nerve and to the lamina cribrosa through which the nerve passes. The ciliary muscle governs the accommodative movement of the elastic network. With age ciliary muscle mobility is restricted by progressively inelastic posterior attachments and the posterior restriction makes the contraction progressively isometric; placing increased tension on the optic nerve region...
July 22, 2016: Experimental Eye Research
Yong Woo Kim, Michael J A Girard, Jean Martial Mari, Jin Wook Jeoung
PURPOSE: To investigate lamina cribrosa (LC) displacement during the Valsalva maneuver in young healthy eyes using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). METHODS: Forty-eight eyes of 48 young healthy volunteers (age range: 20-34 years) underwent intraocular pressure (IOP) measurement by Goldmann applanation tonometry as well as Cirrus HD-OCT scans before and during the Valsalva maneuver. The optic nerve head (ONH) parameters (average retinal nerve fiber layer thickness, rim area, disc area, average C/D ratio, vertical C/D ratio, cup volume), anterior LC depth (LCD), subfoveal and peripapillary choroidal thickness, and neural canal opening diameter were measured on compensated OCT and compared during Valsalva challenge...
2016: PloS One
Glen P Sharpe, Vishva M Danthurebandara, Jayme R Vianna, Noor Alotaibi, Donna M Hutchison, Anne C Belliveau, Lesya M Shuba, Marcelo T Nicolela, Balwantray C Chauhan
PURPOSE: To determine whether structural abnormalities of the lamina cribrosa explain the presence of optic disc hemorrhages, we determined the spatial concordance between disc hemorrhages and laminar disinsertions from the sclera. DESIGN: Prospective noninterventional study. PARTICIPANTS: From open-angle glaucoma patients followed up prospectively, we identified 52 eyes of 46 open-angle glaucoma patients with optic disc hemorrhage (ODH+ group) in at least 1 optic disc photograph during follow-up...
September 2016: Ophthalmology
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