keyword
MENU ▼
Read by QxMD icon Read
search

Lamina Cribrosa

keyword
https://www.readbyqxmd.com/read/29755823/optic-nerve-avulsion-and-retinal-detachment-after-penetrating-ocular-trauma-case-report
#1
Mehmet Fatih Kağan Değirmenci, Nilüfer Yalçındağ, Hüban Atilla
Optic nerve avulsion is a rare pathology with poor prognosis usually seen after blunt trauma. The optic nerve is separated from the sclera by indirect forces due to the relatively weak structure of the lamina cribrosa area. Here we describe an 11-year-old boy who experienced optic nerve avulsion and retinal detachment after penetrating ocular trauma.
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29740064/tortuous-pore-path-through-the-glaucomatous-lamina-cribrosa
#2
Bo Wang, Katie A Lucy, Joel S Schuman, Ian A Sigal, Richard A Bilonick, Chen Lu, Jonathan Liu, Ireneusz Grulkowski, Zachary Nadler, Hiroshi Ishikawa, Larry Kagemann, James G Fujimoto, Gadi Wollstein
The lamina cribrosa is a primary site of damage in glaucoma. While mechanical distortion is hypothesized to cause reduction of axoplasmic flow, little is known about how the pores, which contains the retinal ganglion cell axons, traverse the lamina cribrosa. We investigated lamina cribrosa pore paths in vivo to quantify differences in tortuosity of pore paths between healthy and glaucomatous eyes. We imaged 16 healthy, 23 glaucoma suspect and 48 glaucomatous eyes from 70 subjects using a swept source optical coherence tomography system...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29677362/deep-layer-microvasculature-dropout-by-optical-coherence-tomography-angiography-and-microstructure-of-parapapillary-atrophy
#3
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Tadamichi Akagi, Alberto Diniz-Filho, Luke Saunders, Robert N Weinreb
Purpose: To investigate the association between the microstructure of β-zone parapapillary atrophy (βPPA) and parapapillary deep-layer microvasculature dropout assessed by optical coherence tomography angiography (OCT-A). Methods: Thirty-seven eyes with βPPA devoid of the Bruch's membrane (BM) (γPPA) ranging between completely absent and discontinuous BM were matched by severity of the visual field (VF) damage with 37 eyes with fully intact BM (βPPA+BM) based on the spectral-domain (SD) OCT imaging...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29659152/cranial-pair-i-the-olfactory-nerve
#4
Carlos Crespo, Teresa Liberia, José Miguel Blasco-Ibáñez, Juan Nácher, Emilio Varea
The olfactory nerve constitutes the first cranial pair. Compared with other cranial nerves, it depicts some atypical features. First, the olfactory nerve does not form a unique bundle. The olfactory axons join other axons and form several small bundles or fascicles: the fila olfactoria. These fascicles leave the nasal cavity, pass through the lamina cribrosa of the ethmoid bone and enter the brain. The whole of these fascicles is what is known as the olfactory nerve. Second, the olfactory sensory neurons, whose axons integrate the olfactory nerve, connect the nasal cavity and the brain without any relay...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29651628/intracranial-and-intraocular-pressure-at-the-lamina-cribrosa-gradient-effects
#5
REVIEW
Gauti Jóhannesson, Anders Eklund, Christina Lindén
PURPOSE OF REVIEW: A pressure difference between the intraocular and intracranial compartments at the site of the lamina cribrosa has been hypothesized to have a pathophysiological role in several optic nerve head diseases. This paper reviews the current literature on the translamina cribrosa pressure difference (TLCPD), the associated pressure gradient, and its potential pathophysiological role, as well as the methodology to assess TLCPD. RECENT FINDINGS: For normal-tension glaucoma (NTG), initial studies indicated low intracranial pressure (ICP) while recent findings indicate that a reduced ICP is not mandatory...
April 12, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29625480/microvascular-density-is-associated-with-retinal-ganglion-cell-axonal-volume-in-the-laminar-compartments-of-the-human-optic-nerve-head
#6
Min H Kang, Mengchen Suo, Chandrakumar Balaratnasingam, Paula K Yu, William H Morgan, Dao-Yi Yu
Purpose: To quantify associations between microvascular density and retinal ganglion cell (RGC) axonal volume in the laminar compartments of the human optic nerve head (ONH). Methods: Eleven normal human ONHs were evaluated. Antibodies were used to label the vascular endothelium (factor VIII-related antigen/von Willebrand factor antibody) and RGC axons (neurofilament heavy antibody). Three-dimensional analysis of confocal scanning laser microscope images was used to study microvascular density and RGC axonal volume in the prelaminar, anterior lamina cribrosa, posterior lamina cribrosa, and retrolaminar compartments...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29613982/association-between-the-deep-layer-microvasculature-dropout-and-the-visual-field-damage-in-glaucoma
#7
Min Hee Suh, Jun Woo Park, Hae Rang Kim
PURPOSE: To compare the visual field (VF) sensitivity according to the presence of parapapillary deep-layer microvasculature dropout (MvD_P) and focal lamina cribrosa (LC) defect. METHODS: Among 158 open-angle glaucoma patients, 4 groups were formed according to the presence of MvD_P and focal LC defect determined by optical coherence tomography (OCT) angiography and by enhanced depth imaging spectral-domain OCT, respectively: (1) eyes without either focal LC defect or MvD_P (group 1); (2) eyes with focal LC defect but no MvD_P (group 2); (3) eyes without focal LC defect but with MvD_P (group 3); (4) eyes with both focal LC defect and MvD_P (group 4)...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29611373/lamina-cribrosa-changes-after-laser-in-situ-keratomileusis-in-myopic-eyes
#8
Soomin Lee, Da Ye Diana Choi, Dong Hui Lim, Tae Young Chung, Jong Chul Han, Changwon Kee
PURPOSE: To determine deep optic nerve head structure changes after transient intraocular pressure elevation during laser in situ keratomileusis (LASIK) for myopia. METHODS: Enhanced depth imaging-optical coherence tomography was performed in each myopic eye that underwent LASIK surgery. Enhanced depth imaging-optical coherence tomography images were created at postoperative 1 day, 1 week, 2 weeks, and 1 month. Lamina cribrosa (LC) thickness, LC depth and prelaminar thickness at the superior, middle and inferior portions of the optic nerve head were measured by two investigators...
March 13, 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29588569/in-vivo-assessment-of-changes-in-corneal-hysteresis-and-lamina-cribrosa-position-during-acute-intraocular-pressure-elevation-in-eyes-with-markedly-asymmetrical-glaucoma
#9
Corrado Gizzi, Mauro Cellini, Emilio C Campos
Purpose: To investigate the biomechanical response of the cornea, lamina cribrosa (LC), and prelaminar tissue (PT) to an acute intraocular pressure (IOP) increase in patients with markedly asymmetrical glaucoma and in healthy controls. Patients and methods: A total of 24 eyes of 12 patients with markedly asymmetrical primary open-angle glaucoma (POAG) and 12 eyes of 12 healthy patients were examined with spectral-domain optical coherence tomography (SD-OCT) and ocular response analyzer (ORA) at baseline and during acute IOP elevation by means of an ophthalmodynamometer...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29575652/noninvasive-evaluation-of-cerebrospinal-fluid-pressure-in-ocular-hypertension-a-preliminary-study
#10
Xiaobin Xie, Weiwei Chen, Zhen Li, Ravi Thomas, Yong Li, Junfang Xian, Diya Yang, Huaizhou Wang, Shoukang Zhang, Zefeng Kang, Ningli Wang
PURPOSE: To compare the orbital cerebral spinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls. METHODS: Cross-sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mm Hg) was estimated from a published formula as 17.54 × MRI derived OSASW at 15 mm behind the globe + 0.47 × body mass index + 0...
March 24, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29574185/collagen-fiber-recruitment-a-microstructural-basis-for-the-nonlinear-response-of-the-posterior-pole-of-the-eye-to-increases-in-intraocular-pressure
#11
Ning-Jiun Jan, Ian A Sigal
Our goal was to quantify and characterize how the collagen fiber crimp waviness of the lamina cribrosa (LC) and peripapillary sclera (PPS) changes with intraocular pressure (IOP). Thirteen sheep (ovine) eyes were immersion and perfusion fixed while maintaining IOP at 0, 10, 15, 20, or 50mmHg. Coronal optic nerve head (ONH) sections (30 µm) were imaged with polarized light microscopy (PLM) and analyzed for collagen fiber orientation and waviness (SD of fiber orientation). In the LC, the waviness of every LC beam was measured...
March 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29564937/simultaneous-evaluation-of-the-lamina-cribosa-position-and-choroidal-thickness-changes-following-deep-sclerectomy
#12
Gema Rebolleda, Victoria de Juan, Francisco J Muñoz-Negrete, Laura Díez-Álvarez
PURPOSE: To assess the changes in peripapillary and macular choroidal thickness, and in the lamina cribrosa position following deep sclerectomy. METHODS: Prospective study, including 39 eyes with open-angle glaucoma following deep sclerectomy. Choroidal thickness was automatically measured using swept-source optical coherence tomography at four peripapillary locations (superior, temporal, inferior, and nasal) and at the macular area in nine fields plotted with Early Treatment Diabetic Retinopathy Study grid...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29559412/focal-lamina-cribrosa-defect-in-myopic-eyes-with-non-progressive-glaucomatous-visual-field-defect
#13
Yu Sawada, Makoto Araie, Hitomi Kasuga, Makoto Ishikawa, Toyoto Iwata, Katsuyuki Murata, Takeshi Yoshitomi
PURPOSE: To investigate focal lamina cribrosa (LC) defect that spatially correspond to the non-progressive glaucomatous visual field defect (VFD) in myopic subjects. DESIGN: Case-control study. SUBJECTS: We included 159 myopic eyes with glaucomatous VFD under treatment and followed up for 7 years. METHODS: Serial enhanced depth imaging spectral domain-optical coherence tomography (EDI OCT) B-scans of the optic discs were acquired at the end of the follow-up and reviewed for the LC defect...
March 17, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29557388/the-effect-of-increased-intra-abdominal-pressure-on-orbital-subarachnoid-space-width-and-intraocular-pressure
#14
Su-Meng Liu, Ning-Li Wang, Zhen-Tao Zuo, Wei-Wei Chen, Di-Ya Yang, Zhen Li, Yi-Wen Cao
In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can relieve glaucomatous optic neuropathy. Increased intracranial pressure can also reduce optic nerve damage in glaucoma patients, and a safe, effective and noninvasive way to achieve this is by increasing the intra-abdominal pressure. The purpose of this study was to observe the changes in orbital subarachnoid space width and intraocular pressure at elevated intra-abdominal pressure...
February 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29544962/positional-change-of-optic-nerve-head-vasculature-during-axial-elongation-as-evidence-of-lamina-cribrosa-shifting-boramae-myopia-cohort-study-report-2
#15
Kyoung Min Lee, Ho-Kyung Choung, Martha Kim, Sohee Oh, Seok Hwan Kim
PURPOSE: To investigate the positional change of central retinal vasculature and vascular trunk to deduce the change in the lamina cribrosa (LC) during axial elongation. DESIGN: Prospective cohort study. PARTICIPANTS: Twenty-three healthy myopic children (46 eyes). METHODS: Participants had undergone a full ophthalmologic examination and axial length measurement every 6 months for 2 years. Using spectral-domain OCT, circle scans centered around the optic disc in the glaucoma progression analysis mode, which enabled capturing of the same positions throughout the entire study period, and enhanced depth imaging of the deep optic nerve head complex were performed...
March 12, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29462015/macular-vessel-density-in-glaucomatous-eyes-with-focal-lamina-cribrosa-defects
#16
Elham Ghahari, Christopher Bowd, Linda M Zangwill, Min Hee Suh, Takuhei Shoji, Kyle A Hasenstab, Luke J Saunders, Sasan Moghimi, Huiyuan Hou, Patricia I C Manalastas, Rafaella C Penteado, Robert N Weinreb
PURPOSE: To compare optical coherence tomography angiography (OCTA) measured macular vessel density and spectral domain optical coherence tomography (SDOCT) measured macular ganglion cell complex (GCC) thickness in primary open-angle glaucoma eyes with and without focal lamina cribrosa (LC) defects. METHODS: In this cross-sectional, case-control study of patients with primary open-angle glaucoma, 46 eyes of 46 patients with LC defects and 54 eyes of 54 patients without observable LC defects were included...
April 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29440700/age-related-changes-in-the-response-of-retinal-structure-function-and-blood-flow-to-pressure-modification-in-rats
#17
Da Zhao, Christine T O Nguyen, Zheng He, Vickie H Y Wong, Anna K van Koeverden, Algis J Vingrys, Bang V Bui
Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the brain (intracranial pressure, ICP) can modify the risk of glaucoma. In this study, we consider whether the optic nerve in older rat eyes is more susceptible to acute IOP and ICP modification. We systematically manipulate both ICP and IOP and quantify their effects on ganglion cell function (electroretinography, ERG), optic nerve structure (optical coherence tomography, OCT) and retinal blood flow (Doppler OCT)...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432335/extracellular-matrix-regulation-and-dysregulation-in-exfoliation-syndrome
#18
Matthias Zenkel
Several lines of evidence, such as ultrastructural signs for activated fibrillogenesis and excessive production of elastic microfibrillar components in the anterior segment of the eye and throughout the body, indicate that exfoliation syndrome (XFS) is an elastic microfibrillopathy, leading to the accumulation of an abnormal extracellular fibrillar material (XFM). The upregulation of elastic microfibrillar components is paralleled by the selective upregulation of the cross-linking enzyme lysyl oxidase-like 1 (LOXL1) in the early phase of the disease, suggesting that LOXL1 participates in the stabilization of newly synthesized elastic proteins and finally in the stable accumulation of XFM...
February 9, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29432334/mechanisms-of-glaucoma-in-exfoliation-syndrome
#19
Mineo Ozaki
The most important characteristic of exfoliation syndrome (XFS) is that it involves a greater risk of developing glaucoma. In comparison with other forms of open-angle glaucoma, exfoliation glaucoma (XFG) is more resistant to medical therapy and progresses faster. Possible pathological mechanisms of glaucoma development in XFS comprise: (1) elevated intraocular pressure (IOP) caused by functional impairment of aqueous humor outflow due to deposition of exfoliation material (XFM) in the trabecular meshwork and trabecular cell dysfunction, (2) XFS-associated connective tissue elastosis leading to structural and functional alterations of the lamina cribrosa which increases the vulnerability toward elevated IOP and development of glaucomatous optic neuropathy, (3) elevated IOP due to closure of the anterior chamber angle accompanied by forward displacement of the crystalline lens due to zonular weakness, (4) presumable primary functional impairment of retinal ganglion cells...
February 9, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29423838/evaluating-displacement-of-lamina-cribrosa-following-glaucoma-surgery
#20
Patrycja Krzyżanowska-Berkowska, Aleksandra Melińska, Iwona Helemejko, D Robert Iskander
PURPOSE: The purpose of the study is to assess the displacement of lamina cribrosa (LC) and prelaminar tissue area (PTA) changes following trabeculectomy and non-penetrating deep sclerectomy (NPDS) using spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging technology. METHODS: A total of 30 patients underwent glaucoma surgery. Sixteen patients underwent trabeculectomy, and 14 patients undertook NPDS. Serial horizontal B-scan images of optic nerve head (ONH) were obtained using SD-OCT preoperatively, and at 2-week, 1-, 3-, and 6-month postoperative visit (6 pv)...
April 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
keyword
keyword
10876
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"