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Lamina Cribrosa

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https://www.readbyqxmd.com/read/28074272/-role-of-the-aging-visual-system-in-glaucoma
#1
J D Unterlauft, M R R Böhm
BACKGROUND: Glaucoma is the second leading cause of blindness worldwide and is usually diagnosed in higher age groups. The goal was to survey how patient age influences the development of glaucoma. MATERIALS AND METHODS: A web-based search on aging of the visual system and its influence on glaucoma was performed and the most important results are summarized. RESULTS: The prevalence of glaucoma rises with age. Aging processes of the trabecular meshwork and the uveoscleral outflow pathway lead to a rise in the intraocular pressure...
January 10, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28003987/biomechanics-of-the-sclera-and-effects-on-intraocular-pressure
#2
REVIEW
Xu Jia, Juan Yu, Sheng-Hui Liao, Xuan-Chu Duan
Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative disease characterized by the loss of retinal ganglion cells (RGC), resulting in gradual and progressive permanent loss of vision. Reducing intraocular pressure (IOP) remains the only proven method for preventing and delaying the progression of glaucomatous visual impairment. However, the specific role of IOP in optic nerve injury remains controversial, and little is known about the biomechanical mechanism by which elevated IOP leads to the loss of RGC...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27998461/-research-advances-of-optic-nerve-lamina-cribrosa-structure-and-its-measurement-analysis
#3
T Tian, Y Z Pan
The lamina cribrosa (LC) is believed to be site of injury to retina ganglion cell axons in glaucoma. The ability to visualize this structure helps us increase the understanding of pathophysiological process of glaucoma. At the same time, it is helpful in the early detection and treatment of glaucoma. While for many years the researches on the LC were essentially dependent on histology. With the development of optical coherence tomography (OCT) in recent years, it is possible to image the LC in vivo in both animals and human...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27977479/pilot-study-of-lamina-cribrosa-intensity-measurements-in-glaucoma-using-swept-source-optical-coherence-tomography
#4
Sowmya Srinivas, Anna Dastiridou, Mary K Durbin, Muneeswar G Nittala, Alex A Huang, James C H Tan, Brian A Francis, Srinivas R Sadda, Vikas Chopra
PURPOSE: To compare the lamina cribrosa (LC) intensity in glaucoma-suspect eyes and eyes with mild to moderate glaucoma using swept-source optical coherence tomography. METHODS: Optic disc volume scans were collected using swept-source optical coherence tomography in 19 clinically defined glaucoma-suspect eyes and 29 eyes with mild to moderate glaucoma. LC intensity was measured using Image J software, and the resultant values were normalized using the retinal pigment epithelium and vitreous signal...
December 13, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27935604/ocular-characteristics-associated-with-the-location-of-focal-lamina-cribrosa-defects-in-open-angle-glaucoma-patients
#5
H-Yl Park, Y S Hwang, C K Park
PurposeTo investigate the clinical characteristics according to the location of focal lamina cribrosa (LC) defects and its associated ocular features.Patients and methodsA total of 139 open-angle glaucoma patients underwent Spectralis optical coherence tomography (OCT) with enhanced depth imaging. Alterations in the contour of the LC were investigated to find focal LC defects. The location of the visible LC defect from the neural canal wall (far-peripheral and mid-peripheral) and clock-hour position (superotemporal, temporal and inferotemporal) were classified...
December 9, 2016: Eye
https://www.readbyqxmd.com/read/27916682/adaptive-optics-optical-coherence-tomography-in-glaucoma
#6
REVIEW
Zachary M Dong, Gadi Wollstein, Bo Wang, Joel S Schuman
Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT and the implementation of adaptive optics (AO) into OCT...
December 1, 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27909833/verification-of-a-virtual-fields-method-to-extract-the-mechanical-properties-of-human-optic-nerve-head-tissues-in-vivo
#7
Liang Zhang, Sri Gowtham Thakku, Meghna R Beotra, Mani Baskaran, Tin Aung, James C H Goh, Nicholas G Strouthidis, Michael J A Girard
We aimed to verify a custom virtual fields method (VFM) to estimate the patient-specific biomechanical properties of human optic nerve head (ONH) tissues, given their full-field deformations induced by intraocular pressure (IOP). To verify the accuracy of VFM, we first generated 'artificial' ONH displacements from predetermined (known) ONH tissue biomechanical properties using finite element analysis. Using such deformations, if we are able to match back the known biomechanical properties, it would indicate that our VFM technique is accurate...
December 1, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27898470/lamina-cribrosa-in-glaucoma
#8
J Crawford Downs, Christopher A Girkin
PURPOSE OF REVIEW: This article presents, summarizes, and interprets the most recent advances in the study and understanding of the lamina cribrosa in glaucoma, in the context of previous work. RECENT FINDINGS: The lamina is an active living structure that responds to strain by changing morphology at the micro-scale and macro-scale in glaucoma. Changes in lamina cribrosa morphology in glaucoma include posteriorization of the laminar insertion into the sclera, increased cupping or depth of the lamina cribrosa, and the development of focal lamina cribrosa defects...
November 25, 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27846047/optic-nerve-head-histopathology-in-high-axial-myopia
#9
Jost B Jonas, Kyoko Ohno-Matsui, Songhomitra Panda-Jonas
PURPOSE: To describe particularities of the optic nerve head of axially highly myopic eyes. METHODS: Measurements were obtained from enucleated globes and from population-based studies. RESULTS: Morphologic optic disc particularities in high axial myopia included enlarged disc size (secondary macrodisc), widening and temporal translocation of the papillary Bruch's membrane (BM) opening, parapapillary gamma and delta zone, elongation and thinning of lamina cribrosa and peripapillary scleral flange, steeper translamina cribrosa pressure gradient, decreased peripapillary choroid thickness, longer distance between peripapillary arterial circle and optic disc, optic cup flattening, presumably a stretching of the lamina cribrosa pores, and peripapillary intrachoroidal cavitations...
November 11, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27813193/the-importance-of-and-potential-for-continuous-monitoring-of-intraocular-pressure
#10
REVIEW
Charles W McMonnies
Monitoring intraocular pressure (IOP) is a critically important part of glaucoma management; however, clinical tonometry predominantly involves sitting postures and is unable to detect variations in response to posture changes, muscular effort, deep respirations and during a wide range of activities, such as playing high wind-resistance instruments and wearing swimming goggles in addition to eye touching and rubbing. For example, the usefulness of 24-hour tonometric phasing may be increased, if nocturnal assessments included side and prone sleeping postures rather than being limited to supine posture tonometry...
November 3, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27802488/in-vivo-3-dimensional-strain-mapping-confirms-large-optic-nerve-head-deformations-following-horizontal-eye-movements
#11
Xiaofei Wang, Meghna R Beotra, Tin Aung Tun, Mani Baskaran, Shamira Perera, Tin Aung, Nicholas G Strouthidis, Dan Milea, Michaël J A Girard
Purpose: To measure lamina cribrosa (LC) strains (deformations) following abduction and adduction in healthy subjects and to compare them with those resulting from a relatively high acute intraocular pressure (IOP) elevation. Methods: A total of 16 eyes from 8 healthy subjects were included. Among the 16 eyes, 11 had peripapillary atrophy (PPA). For each subject, both optic nerve heads (ONHs) were imaged using optical coherence tomography (OCT) at baseline (twice), in different gaze positions (adduction and abduction of 20°) and following an acute IOP elevation of approximately 20 mm Hg from baseline (via ophthalmodynamometry)...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27796669/vertical-asymmetry-of-lamina-cribrosa-tilt-angles-using-wide-bandwidth-femtosecond-mode-locked-laser-oct-effect-of-myopia-and-glaucoma
#12
Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Makoto Araie, Shin Yoneya
PURPOSE: Morphological features of the lamina cribrosa (LC) and optic disc may be important in the pathogenesis of glaucoma and myopic neuropathy. We therefore performed a cross-sectional study of patients with glaucoma and myopic neuropathy to evaluate vertical asymmetry of LC tilt angles (LCTAs) from Bruch's membrane opening (BMO). MATERIAL AND METHODS: Forty-six control eyes and 35 primary open-angle glaucoma (POAG) eyes were included. A raster scanning protocol with 300 single B-scans (without averaging) were obtained using optical coherence tomography with a wide-bandwidth, femtosecond mode-locked (ML) laser...
January 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27784074/optic-nerve-head-biomechanic-and-iop-changes-before-and-after-the-injection-of-aflibercept-for-neovascular-age-related-macular-degeneration
#13
Gema Rebolleda, Beatriz Puerto, Victoria de Juan, Marta Gómez-Mariscal, Francisco José Muñoz-Negrete, Alfonso Casado
Purpose: We investigated the early effects of intravitreal aflibercept injection (IAI) on optic nerve head (ONH) morphology. Methods: All of the participants underwent applanation tonometry and enhanced depth imaging by spectral-domain optical coherence tomography immediately before injection, and within 5 and 30 minutes after IAI. Changes in the anterior lamina cribrosa surface depth, prelaminar tissue thickness (PTT), optic cup width, optic cup depth, and Bruch's membrane opening (BMO) were assessed...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27770194/-imaging-of-the-lamina-cribrosa-for-early-detection-of-glaucoma-latest-trends-from-the-annual-arvo-meeting-2016
#14
J Matlach, N Pfeiffer, V Prokosch-Willing
Studying the lamina cribrosa (LC) is relevant to understand the mechanisms of retinal ganglion cell degeneration in glaucoma and develop new diagnostic and therapeutic strategies. We would like to present some of the emerging trends and hot topics in imaging of the lamina cribrosa in glaucoma from the 2016 ARVO (The Association of Research in Vision and Ophthalmology) annual meeting, which was held in Seattle, WA, USA. Presentation of the path of ganglion cells through the pores of the lamina cribrosa as well as changes to the shape of the lamina cribrosa with increase of the intraocular and intracerebral pressure have been of great international interest...
October 21, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27769587/deep-retinal-layer-microvasculature-dropout-detected-by-the-optical-coherence-tomography-angiography-in-glaucoma
#15
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Robert N Weinreb
PURPOSE: To investigate factors associated with dropout of the parapapillary deep retinal layer microvasculature assessed by optical coherence tomography angiography (OCTA) in glaucomatous eyes. DESIGN: Cross-sectional study. PARTICIPANTS: Seventy-one eyes from 71 primary open-angle glaucoma (POAG) patients with β-zone parapapillary atrophy (βPPA) enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: Parapapillary deep-layer microvasculature dropout was defined as a complete loss of the microvasculature located within the deep retinal layer of the βPPA from OCTA-derived optic nerve head vessel density maps by standardized qualitative assessment...
October 18, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27764824/intra-and-inter-rater-agreement-of-anterior-lamina-cribrosa-depth-measurements-using-enhanced-depth-imaging-optical-coherence-tomography
#16
Inês Leal, David Cordeiro Sousa, Filomena Pinto, Carlos Marques-Neves, Luís Abegão Pinto
PURPOSE: To determine intra- and inter-rater agreement of anterior lamina cribrosa depth (ALCD) manual measurements using enhanced-depth imaging optical coherence tomography (EDI-OCT). METHODS: Observational study. EDI-OCT of the optic nerve head was performed in healthy subjects. ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa (LC), at the maximum depth point...
October 21, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27755347/optic-disc-characteristics-and-visual-field-progression-in-normal-tension-glaucoma-patients-with-tilted-optic-discs
#17
Youngkyo Kwun, Gyule Han, Yoon-Jung Choy, Jong Chul Han, Changwon Kee
PURPOSE OF THE STUDY: The purpose of the study was to evaluate the optic disc characteristics associated with visual field (VF) progression in normal tension glaucoma (NTG) eyes with tilted optic discs. METHODS: Sixty-six eyes of 66 NTG patients with tilted optic disc were included in this cross-sectional study, who were examined by at least 5 Humphrey 30-2 VFs. Glaucomatous VF progression was evaluated using pointwise linear regression. Optic nerve heads were scanned with enhanced-depth imaging optical coherence tomography (EDI-OCT), and evaluated for the focal lamina cribrosa (LC) defects and LC thicknesses...
October 14, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27707691/optical-coherence-tomography-angiography-an-overview-of-the-technology-and-an-assessment-of-applications-for-clinical-research
#18
REVIEW
Andrew Koustenis, Alon Harris, Josh Gross, Ingrida Januleviciene, Aaditya Shah, Brent Siesky
In recent years, ophthalmology has experienced significant developments with respect to imaging modalities. Optical coherence tomography angiography is one such technology that seeks to improve diagnostics for retinal diseases. Using standard structural ocular coherence tomography hardware, optical coherence tomography angiography demonstrates the ability to non-invasively visualise the vasculature in the retina and the choroid with high resolution, allowing greater insight into retinal vascular pathologies...
January 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27662409/swept-source-optical-coherence-tomography-validates-lamina-cribrosa-anomaly-in-optic-disk-pit
#19
Kumar Sambhav, Sandeep Grover, K V Chalam
PURPOSE: Swept Source Optical Coherence Tomography validates lamina cribrosa anomaly in optic disk pit. METHOD: Observational case report. RESULTS: A 25-year-old African American male presented with decreased vision in right eye of 4 days duration. Best corrected visual acuity (BCVA) for distance in right eye was 20/200 and in left eye was 20/20. Dilated fundus examination of right eye showed serous macular detachment of entire posterior pole along with an optic pit on temporal margin of optic disk...
September 22, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27646335/relationship-between-intraocular-pressure-and-anterior-lamina-cribrosa-depth-a-cross-sectional-observational-study-in-a-healthy-portuguese-population
#20
David Cordeiro Sousa, Inês Leal, Carlos Marques-Neves, Filomena Pinto, Luís Abegão Pinto
PURPOSE: To investigate the association between anterior lamina cribrosa depth (ALCD), determined with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT), and intraocular pressure (IOP) in a healthy Portuguese population. METHODS: In this cross-sectional observational study conducted between January and July 2015, 2 optic nerve head (ONH)-centered EDI-OCT cross-scans were performed and ALCD was defined as the perpendicular distance between the line connecting both edges of Bruch's membrane opening and the anterior border of the lamina cribrosa at the maximum depth point...
September 13, 2016: European Journal of Ophthalmology
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