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Lamina Cribrosa

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https://www.readbyqxmd.com/read/28922330/lamina-cribrosa-thickness-in-patients-with-keratoconus
#1
Serkan Akkaya, Bekir Küçük
PURPOSE: To evaluate the thickness and depth of lamina cribrosa (LC) in the optic nerve head region of the eyes in patients with nonglaucomatous keratoconus and to compare the thickness and depth with those of age-matched controls. METHODS: This was a cross-sectional, observational study comprising 45 patients with keratoconus and 56 healthy subjects. Analysis of LC imaging was performed using spectral domain optical coherence tomography. Data collected included spherical equivalent, central corneal thickness, axial length, intraocular pressure, and keratometry...
September 14, 2017: Cornea
https://www.readbyqxmd.com/read/28922031/optic-nerve-head-characteristics-in-chronic-angle-closure-glaucoma-detected-by-swept-source-oct
#2
Dejiao Li, Taibo Li, Eleftherios I Paschalis, Haobing Wang, Elise V Taniguchi, Zi-Ning Choo, Marissa K Shoji, Scott H Greenstein, Stacey C Brauner, Angela V Turalba, Louis R Pasquale, Lucy Q Shen
PURPOSE: To compare structural features in prelaminar and laminar tissues of the optic nerve head (ONH) in chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG), and control subjects. MATERIALS AND METHODS: ONH imaging was performed using swept-source optical coherence tomography (SS-OCT) for measurements of minimum rim width at Bruch's membrane opening (BMO-MRW), horizontal, and vertical lamina cribrosa depth (LCD). Prelaminar defects, categorized as hole and wedge, and lamina cribrosa (LC) defects were identified...
September 18, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28864288/a-novel-hypothesis-for-the-pathogenesis-of-glaucomatous-disc-hemorrhage
#3
REVIEW
Eun Jung Lee, Jong Chul Han, Changwon Kee
Disc hemorrhage is known to be associated with glaucoma development and progression. Several hypotheses have been proposed to explain the pathogenesis of disc hemorrhage in glaucoma, including mechanical and ischemic theories. However, no theory has yet provided a clear explanation of cellular-level events and related histologic findings. Moreover, research has yet to elucidate why glaucomatous disc hemorrhage occurs around the optic disc and at the margin of the retinal nerve fiber layer defect. Understanding the pathogenic mechanism of disc hemorrhage will facilitate interpretation of its clinical importance, and provide better insight into clinical practice...
August 30, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28858414/association-of-intraocular-pressure-related-factors-and-retinal-vessel-diameter-with-optic-disc-rim-area-in-subjects-with-and-without-primary-open-angle-glaucoma
#4
Qing Zhang, Catherine Jan, Chun Yu Guo, Feng Hua Wang, Yuan Bo Liang, Kai Cao, Zheng Zhang, Di Ya Yang, Ravi Thomas, Ning Li Wang
IMPORTANCE: The data may supports the notion that the mechanical and vascular mechanisms of glaucomatous injury are intertwined BACKGROUND: To study the association of intraocular pressure (IOP) related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DESIGN: A population-based, cross-sectional study PARTICIPANTS: 6830 people aged 30 years and over...
August 31, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28857943/visibility-of-optic-nerve-head-structures-with-spectral-domain-and-swept-source-optical-coherence-tomography
#5
Mónica M Loureiro, Jayme R Vianna, Vishva M Danthurebandara, Glen P Sharpe, Donna M Hutchison, Marcelo T Nicolela, Balwantray C Chauhan
PURPOSE: To compare the visibility of deep optic nerve head (ONH) structures and the visible area of the anterior surface of the lamina cribrosa (ASLC) with spectral-domain optical coherence tomography (SD-OCT) and swept-source OCT (SS-OCT). MATERIALS AND METHODS: In total, 33 glaucoma patients were imaged with SD-OCT (Spectralis, 24 radial B-scans centered on the ONH) and SS-OCT (Atlantis, 12 radial and a horizontal and vertical raster scan pattern containing 5 lines each, centered on the ONH)...
September 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28855629/location-of-the-central-retinal-vessel-trunk-in-the-laminar-and-prelaminar-tissue-of-healthy-and-glaucomatous-eyes
#6
Bo Wang, Katie A Lucy, Joel S Schuman, Hiroshi Ishikawa, Richard A Bilonick, Ian A Sigal, Larry Kagemann, Chen Lu, James G Fujimoto, Gadi Wollstein
Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT)...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28834826/valsalva-maneuver-induced-changes-in-anterior-lamina-cribrosa-surface-depth-a-comparison-between-normal-and-glaucomatous-eyes
#7
Young Kook Kim, Ahnul Ha, Yong Ju Song, Kyeong Ik Na, Won June Lee, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate the influence of the Valsalva maneuver (VM) on anterior lamina cribrosa surface depth (ALCSD), and to compare normal with treated glaucomatous eyes in terms of this effect. METHODS: Thirty-two patients (32 eyes) with early-to-moderate glaucoma under treatment and 30 normal healthy participants (30 eyes) were prospectively enrolled. Study subjects performed the VM by blowing through a mouthpiece attached to a handheld manometer; expiratory pressure during the maneuver ranged from 35 to 40 mmHg...
August 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28829846/racial-differences-in-the-extracellular-matrix-and-histone-acetylation-of-the-lamina-cribrosa-and-peripapillary-sclera
#8
Hae-Young Lopilly Park, Jie Hyun Kim, Younhea Jung, Chan Kee Park
Purpose: We investigated the extracellular matrix (ECM) of the lamina cribrosa (LC) and peripapillary sclera (PPS) and compared histone acetylation and related enzymes to identify racial differences between Korean and Caucasian donor eyes. Methods: Posterior segment tissues were obtained from 30 Caucasian donors and 42 age and axial length-matched Korean donors. Histone modification was assessed for histone deacetylase (HDAC) 2, HDAC3, and acetylated histone H3...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28817389/congenital-anomalies-of-the-optic-disc-insights-from-optical-coherence-tomography-imaging
#9
Karen W Jeng-Miller, Dean M Cestari, Eric D Gaier
PURPOSE OF REVIEW: Congenital anomalies of the optic nerve are rare but significant causes of visual dysfunction in children and adults. Accurate diagnosis is dependent on a thorough funduscopic examination, but can be enhanced by imaging information garnered from optical coherence tomography (OCT). We review common congenital optic nerve anomalies, including optic disc pit, optic nerve coloboma, morning glory disc anomaly, and hypoplasia of the optic nerve, review their systemic associations, and discuss insights from OCT imaging...
August 16, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28789942/statins-reduce-tgf-beta2-modulation-of-the-extracellular-matrix-in-cultured-astrocytes-of-the-human-optic-nerve-head
#10
Mi-Lyang Kim, Kyung Rim Sung, Jin A Shin, Joo Young Yoon, Joonhee Jang
Statins are cholesterol lowering drugs and have shown beneficial effects on glaucoma. With regard to the mechanism of statin action on glaucoma, we investigated the effects of statins on transforming growth factor-beta 2 (TGF-β2)-induced expression of extracellular matrix (ECM) proteins in human astrocytes of the optic nerve head (ONH) lamina cribrosa (LC). By using primary human ONH astrocytes, we found that both simvastatin and lovastatin inhibited TGF-β2-mediated expression of ECM proteins such as connective tissue growth factor, collagen I, fibronectin, and plasminogen activator inhibitor-1...
August 5, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28777226/is-the-optic-nerve-head-structure-impacted-by-a-diagnostic-lumbar-puncture-in-humans
#11
Muriel Poli, Philippe Denis, Eric Sellem, Ludwig-Serge Aho-Glélé, Alain M Bron
PURPOSE: The purpose of this study is to assess in vivo whether diagnostic lumbar puncture (LP) is followed by optic nerve head (ONH) and parapapillary anatomic changes in normal human eyes. MATERIALS AND METHODS: Prospective, single-center, observational case series. ONH structures (prelaminar tissue surface, anterior surface of the lamina cribrosa, central retinal vessels) and parapapillary structures (internal limiting membrane, posterior surfaces of retinal nerve fiber layer and Bruch membrane/retinal pigment epithelium complex, Bruch membrane opening, posterior surface of the choroid) were quantitatively evaluated by means of swept-source optical coherence tomography (Triton Ver...
August 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28742840/glaucomatous-changes-in-lamina-pores-shape-within-the-lamina-cribrosa-using-wide-bandwidth-femtosecond-mode-locked-laser-oct
#12
Takuhei Shoji, Hiroto Kuroda, Masayuki Suzuki, Hisashi Ibuki, Makoto Araie, Shin Yoneya
PURPOSE: The lamina cribrosa (LC) is known to play a critical role in the pathogenesis of glaucoma. Although it has been reported that striae-shaped or slit-shaped lamina pores are more frequent in eyes with primary open angle glaucoma (POAG), this observation is based only on fundus photography. The primary object of this study is to perform layer-by-layer comparisons of the shape of lamina pores within the LC in vivo. DESIGN: Cross-sectional study. METHODS: Optic nerve head B-scans were obtained using custom-made broad-wavelength optical coherence tomography with a mode-locked laser...
2017: PloS One
https://www.readbyqxmd.com/read/28738420/variation-in-the-three-dimensional-histomorphometry-of-the-normal-human-optic-nerve-head-with-age-and-race-lamina-cribrosa-and-peripapillary-scleral-thickness-and-position
#13
COMPARATIVE STUDY
Christopher A Girkin, Massimo A Fazio, Hongli Yang, Juan Reynaud, Claude F Burgoyne, Brandon Smith, Lan Wang, J Crawford Downs
Purpose: This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods: A total of 64 eyes (45 ED, 19 AD) from 51 normal donors were obtained within 6 hours of death and fixed at 10 mm Hg of pressure. The optic nerve head was trephined from the globe and digitally reconstructed at 1...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28732047/in-vivo-analysis-of-glaucoma-related-features-within-the-optic-nerve-head-using-enhanced-depth-imaging-optical-coherence-tomography
#14
Tiago S Prata, Flavio S Lopes, Vitor G Prado, Izabela Almeida, Igor Matsubara, Syril Dorairaj, Rafael L Furlanetto, Roberto M Vessani, Augusto Paranhos
Structural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages...
2017: PloS One
https://www.readbyqxmd.com/read/28730092/parameters-of-ocular-fundus-on-spectral-domain-optical-coherence-tomography-for-glaucoma-diagnosis
#15
REVIEW
Yu-Lin Tao, Li-Ming Tao, Zheng-Xuan Jiang, He-Ting Liu, Kun Liang, Mo-Han Li, Xuan-Sheng Zhu, Yan-Lin Ren, Bing-Jie Cui
In this review, we summarize the progression of several parameters assessed by spectral-domain optical coherence tomography (SD-OCT) in recent years for the detection of glaucoma. Monitoring the progression of defects in the retinal nerve fiber layer (RNFL) thickness is essential. Imaging and analysis of retinal ganglion cells (RGCs) and inner plexiform layer (IPL), respectively, have been of great importance. Optic nerve head (ONH) topography obtained from 3D SD-OCT images is another crucial step. Other important assessments involve locating the Bruch's membrane opening (BMO), estimating the optic disc size and rim area, and measuring the lamina cribrosa displacement...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28715592/inter-relationship-of-arterial-supply-to-human-retina-choroid-and-optic-nerve-head-using-micro-perfusion-and-labeling
#16
Paula K Yu, Ian L McAllister, William H Morgan, Stephen J Cringle, Dao-Yi Yu
Purpose: The prevailing view is that the human retina is supplied by the central retinal artery (CRA), the short posterior ciliary arteries (SPCAs) support the choroid, and both the CRA and the SPCAs are so-called "end artery" systems. In this study, we investigate whether vascular connections among the retina, choroid, and the optic nerve head (ONH) exist, using selective cannulation and microperfusion-labeling techniques. Methods: The CRA and/or one or more of the SPCAs were selected for cannulation in 18 human donor eyes...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28687851/microstructural-crimp-of-the-lamina-cribrosa-and-peripapillary-sclera-collagen-fibers
#17
Ning-Jiun Jan, Celeste Gomez, Saundria Moed, Andrew P Voorhees, Joel S Schuman, Richard A Bilonick, Ian A Sigal
Purpose: Although collagen microstructural crimp is a major determinant of ocular biomechanics, no direct measurements of optic nerve head (ONH) crimp have been reported. Our goal was to characterize the crimp period of the lamina cribrosa (LC) and peripapillary sclera (PPS) at low and normal IOPs. Methods: ONHs from 11 sheep eyes were fixed at 10-, 5-, or 0-mm Hg IOP and crimp periods measured manually from coronal cryosections imaged with polarized light microscopy (PLM)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28687850/author-response-biomechanical-responses-of-lamina-cribrosa-to-intraocular-pressure-change-assessed-by-optical-coherence-tomography-in-glaucoma-eyes
#18
Harry A Quigley
No abstract text is available yet for this article.
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28687849/biomechanical-responses-of-lamina-cribrosa-to-intraocular-pressure-change-assessed-by-optical-coherence-tomography-in-glaucoma-eyes
#19
Gema Rebolleda, Laura Díez-Álvarez, Victoria de Juan, Francisco J Muñoz-Negrete
No abstract text is available yet for this article.
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28666629/aging-and-ocular-tissue-stiffness-in-glaucoma
#20
REVIEW
Baiyun Liu, Sara McNally, Jason I Kilpatrick, Suzanne P Jarvis, Colm J O'Brien
Glaucoma is a progressive and chronic neurodegenerative disorder characterized by damage to the inner layers of the retina and deformation of the optic nerve head. The degeneration of retinal ganglion cells and their axons results in an irreversible loss of vision and is correlated with increasing age. Extracellular matrix changes related to natural aging generate a stiffer extracellular environment throughout the body. Altered age-associated ocular tissue stiffening plays a major role in a significant number of ophthalmic pathologies...
June 27, 2017: Survey of Ophthalmology
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