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Lamina Cribrosa

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https://www.readbyqxmd.com/read/28324116/thick-prelaminar-tissue-decreases-lamina-cribrosa-visibility
#1
Katie A Lucy, Bo Wang, Joel S Schuman, Richard A Bilonick, Yun Ling, Larry Kagemann, Ian A Sigal, Ireneusz Grulkowski, Jonathan J Liu, James G Fujimoto, Hiroshi Ishikawa, Gadi Wollstein
Purpose: Evaluation of the effect of prelaminar tissue thickness on visualization of the lamina cribrosa (LC) using optical coherence tomography (OCT). Methods: The optic nerve head (ONH) region was scanned using OCT. The quality of visible LC microstructure was assessed subjectively using a grading system and objectively by analyzing the signal intensity of each scan's superpixel components. Manual delineations were made separately and in 3-dimensions quantifying prelaminar tissue thickness, analyzable regions of LC microstructure, and regions with a visible anterior LC (ALC) boundary...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28323178/study-on-the-deformations-of-the-lamina-cribrosa-during-glaucoma
#2
Hanjing Tian, Long Li, Fan Song
The lamina cribrosa is the primary site of optic nerve injury during glaucoma, and its deformations induced by elevated intraocular pressure are associated directly with the optic nerve injury and visual field defect. However, the deformations in a living body have been poorly understood yet so far. It is because that integral observation and precise measurement of the deformations in vivo are now almost impossible in the clinical diagnosis and treatment of glaucoma. In the present study, a new mechanical model of the lamina cribrosa is presented by using Reissner's thin plate theory...
March 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28260366/-application-value-of-corneal-hysteresis-in-diagnosis-and-treatment-of-glaucoma
#3
L Y He, L Liang, M N Zhu
Glaucoma is the first leading cause of irreversible blindness world widely, but the pathogenesis was still unclear. The collagen fibers from cornea and sclera connect to each other and both of them have similar extracellular matrix components. The biomechanical characteristics of optic nerve lamina cribrosa may associated with the biomechanical properties of the cornea. Therefore, the study of corneal physiological can indirectly reflex the compression and damage in optic nerve lamina cribrosa. The technical developments in corneal hysteresis examination had been updated these years constantly...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28252388/three-dimensional-segmentation-of-the-ex-vivo-anterior-lamina-cribrosa-from-second-harmonic-imaging-microscopy
#4
Sundaresh Ram, Forest Danford, Stephen Howerton, Jeffrey Rodriguez, Jonathan Vande Geest
The lamina cribrosa (LC) 1 is a connective tissue in the posterior eye with a complex mesh-like trabecular microstructure through which all the retinal ganglion cell axons and central retinal vessels pass. Recent studies have demonstrated that changes in the structure of the LC correlate with glaucomatous damage. Thus, accurate segmentation and reconstruction of the LC is of utmost importance. This paper presents a new automated method for segmenting the microstructure of the anterior LC in the images obtained via multiphoton microscopy using a combination of ideas...
February 23, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28251093/enhanced-depth-oct-imaging-of-the-lamina-cribrosa-for-24-hours
#5
Pedro Naranjo-Bonilla, Rafael Giménez-Gómez, David Ríos-Jiménez, María Luísa Varas-Fabra, María Del Carmen Muñoz-Villanueva, Rocío García-Catalán, Pilar Font-Ugalde, María Soledad Poblador-Fernández, José Luís Lancho-Alonso, José María Gallardo-Galera
The lamina cribrosa thickness (LCT) could be affected by dynamic changes in its structure. Using Spectral-domain-optical coherence tomography (SD-OCT), we have studied the behaviour of the laminar region in 14 young subjects over 24h. Significant changes in LCT were observed, depending on the time at which the measurement was taken, with the maximum thickness being observed at 7.30 p.m., and the minimum at 7.30 a.m. This finding could suggests a circadian pattern in the LCT thickness in healthy subjects, which could have implications for the classification, diagnosis and prognosis of both normal and glaucomatous subjects...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28223179/biological-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#6
REVIEW
Ernst R Tamm, C Ross Ethier, John E Dowling, Crawford Downs, Mark H Ellisman, Steven Fisher, Brad Fortune, Marcus Fruttiger, Tatjana Jakobs, Geoffrey Lewis, Claire H Mitchell, John Morrison, Sansar C Sharma, Ian Sigal, Michael Sofroniew, Lin Wang, Janey Wiggs, Samuel Wu, Richard H Masland
Intraocular pressure (IOP) is a critical risk factor in glaucoma, and the available evidence derived from experimental studies in primates and rodents strongly indicates that the site of IOP-induced axonal damage in glaucoma is at the optic nerve head (ONH). However, the mechanisms that cause IOP-induced damage at the ONH are far from understood. A possible sequence of events could originate with IOP-induced stress in the ONH connective tissue elements (peripapillary sclera, scleral canal and lamina cribrosa) that leads to an increase in biomechanical strain...
February 20, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28221329/relationship-between-anterior-lamina-cribrosa-surface-tilt-and-glaucoma-development-in-myopic-eyes
#7
Eun Jung Lee, Jong Chul Han, Changwon Kee
PURPOSE: To evaluate the anterior lamina cribrosa (LC) surface tilt angle in myopic eyes and associate it with glaucoma development. MATERIALS AND METHODS: In this retrospective study, medical records of myopic patients referred for glaucoma examination from July 1, 2012 to March 30, 2016 were reviewed. Comprehensive ophthalmic examination including spectral-domain optical coherence tomography were performed. We measured the angle of anterior LC surface tilt against Bruch's membrane opening from optical coherence tomography images at the center of the clinical optic disc margin...
February 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28197790/surgical-treatment-of-anterior-cranial-fossa-dural-arterio-venous-fistulas-davfs-a-two-centre-experience
#8
Pietro Meneghelli, Alberto Pasqualin, Luigi Andrea Lanterna, Claudio Bernucci, Roberto Spinelli, Gianluigi Dorelli, Piergiuseppe Zampieri
BACKGROUND: Anterior cranial fossa dural arterio-venous fistulas (DAVFs) represent 6% of all intracranial DAVFs; characteristically they show an aggressive behaviour with high risk of intracranial haemorrhage. Peculiar anatomical features, such as feeding by the ethmoidal arteries and the pattern of venous drainage (frequently with varices that mimic aneurysmal dilatation), can be evaluated in detail only by digital subtraction angiography (DSA), which represents the "gold standard" in the diagnosis of such cranial fistulas...
February 14, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28174676/a-digital-staining-algorithm-for-optical-coherence-tomography-images-of-the-optic-nerve-head
#9
Jean-Martial Mari, Tin Aung, Ching-Yu Cheng, Nicholas G Strouthidis, Michaël J A Girard
PURPOSE: To digitally stain spectral-domain optical coherence tomography (OCT) images of the optic nerve head (ONH), and highlight either connective or neural tissues. METHODS: OCT volumes of the ONH were acquired from one eye of 10 healthy subjects. We processed all volumes with adaptive compensation to remove shadows and enhance deep tissue visibility. For each ONH, we identified the four most dissimilar pixel-intensity histograms, each of which was assumed to represent a tissue group...
February 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28168044/anti-inflammatory-and-antioxidative-stress-effects-of-oryzanol-in-glaucomatous-rabbits
#10
Shital S Panchal, Rajesh K Patidar, Abhishek B Jha, Ahmed A Allam, Jamaan Ajarem, Shital B Butani
Purpose. γ-Oryzanol works by anti-inflammatory and radical scavenging activity as a neuroprotective, anticancer, antiulcer, and immunosuppressive agent. The present study was conducted to investigate effect of oryzanol in acute and chronic experimental glaucoma in rabbits. Methods. Effect of oryzanol was evaluated in 5% dextrose induced acute model of ocular hypertension in rabbit eye. Chronic model of glaucoma was induced with subconjunctival injection of 5% of 0.3 ml phenol. Treatment with oryzanol was given for next two weeks after induction of glaucoma...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28146240/diagnostic-power-of-lamina-cribrosa-depth-and-curvature-in-glaucoma
#11
Seung Hyen Lee, Tae-Woo Kim, Eun Ji Lee, Michaël J A Girard, Jean Martial Mari
Purpose: To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes. Methods: Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, sex, and axial length were included. The LCD and lamina cribrosa curvature index (LCCI) were measured in B-scan images obtained using swept-source optical coherence tomography at seven locations spaced equidistantly across the vertical optic disc diameter...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28146238/collagen-architecture-of-the-posterior-pole-high-resolution-wide-field-of-view-visualization-and-analysis-using-polarized-light-microscopy
#12
Ning-Jiun Jan, Kira Lathrop, Ian A Sigal
Purpose: The purpose of this study was to leverage polarized light microscopy (PLM) to visualize the collagen fiber architecture of posterior pole and optic nerve head with micrometer-scale resolution and to identify and quantify major organizational components. Methods: Eight sheep posterior poles were cryosectioned and imaged using PLM. Collagen fiber orientation was determined by using custom scripts, and the resulting orientation maps were inspected and quantified to identify major structural elements and tested for differences in mean fiber orientation and anisotropy, using linear mixed effect models...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28141872/factors-associated-with-the-retinal-nerve-fiber-layer-loss-after-acute-primary-angle-closure-a-prospective-edi-oct-study
#13
Eun Ji Lee, Tae-Woo Kim, Kyoung Min Lee, Seung Hyen Lee, Hyunjoong Kim
PURPOSE: To determine the factors associated with retinal nerve fiber layer (RNFL) loss in eyes with acute primary angle-closure (APAC), particularly focusing on the influence of the change in the anterior lamina cribrosa surface depth (LCD). METHODS: After the initial presentation, 30 eyes with unilateral APAC were followed up at the following specific time points over a 12-month period: 1 week, 1~2 months, 2~3 months, 5~6 months, and 11~12 months. These follow-ups involved intraocular pressure measurements, enhanced depth-imaging spectral-domain optical coherence tomography (SD-OCT) scanning of the optic disc, and measurements of the circumpapillary RNFL thickness...
2017: PloS One
https://www.readbyqxmd.com/read/28129671/glymphatic-stasis-at-the-site-of-the-lamina-cribrosa-as-a-potential-mechanism-underlying-open-angle-glaucoma
#14
REVIEW
Peter Wostyn, Hanspeter Esriel Killer, Peter Paul De Deyn
The underlying pathophysiology of primary open-angle glaucoma remains unclear, but the lamina cribrosa seems to be the primary site of injury, and raised intraocular pressure is a major risk factor. In recent years, a decreased intracranial pressure, leading to an abnormally high trans-lamina cribrosa pressure difference, has gained interest as a new risk factor for glaucoma. New research now lends support to the hypothesis that a paravascular transport system is present in the eye analogous to the recently discovered 'glymphatic system' in the brain, which is a functional waste clearance pathway that promotes elimination of interstitial solutes, including β-amyloid, from the brain along paravascular channels...
January 27, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28108378/the-pressure-induced-deformation-response-of-the-human-lamina-cribrosa-analysis-of-regional-variations
#15
Dan E Midgett, Mary E Pease, Joan L Jefferys, Mohak Patel, Christian Franck, Harry A Quigley, Thao D Nguyen
The objective of this study was to measure the pressure-induced deformation response of the human lamina cribrosa (LC) and analyze for variations with age and anatomical region. The posterior scleral cup of 8 eyes from 6 human donors was mounted onto a custom inflation chamber. A laser-scanning microscope was used for second harmonic generation (SHG) imaging of the collagen structure in the posterior volume of the LC at pressures from 5mmHg to 45mmHg. The SHG volumes were analyzed by the Fast-Fourier Iterative Digital Volume Correlation (DVC) algorithm for the three dimensional (3D) displacement field...
January 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28074272/-role-of-the-aging-visual-system-in-glaucoma
#16
J D Unterlauft, M R R Böhm
BACKGROUND: Glaucoma is the second leading cause of blindness worldwide and is usually diagnosed in higher age groups. The goal was to survey how patient age influences the development of glaucoma. MATERIALS AND METHODS: A web-based search on aging of the visual system and its influence on glaucoma was performed and the most important results are summarized. RESULTS: The prevalence of glaucoma rises with age. Aging processes of the trabecular meshwork and the uveoscleral outflow pathway lead to a rise in the intraocular pressure...
January 10, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28003987/biomechanics-of-the-sclera-and-effects-on-intraocular-pressure
#17
REVIEW
Xu Jia, Juan Yu, Sheng-Hui Liao, Xuan-Chu Duan
Accumulating evidence indicates that glaucoma is a multifactorial neurodegenerative disease characterized by the loss of retinal ganglion cells (RGC), resulting in gradual and progressive permanent loss of vision. Reducing intraocular pressure (IOP) remains the only proven method for preventing and delaying the progression of glaucomatous visual impairment. However, the specific role of IOP in optic nerve injury remains controversial, and little is known about the biomechanical mechanism by which elevated IOP leads to the loss of RGC...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27998461/-research-advances-of-optic-nerve-lamina-cribrosa-structure-and-its-measurement-analysis
#18
T Tian, Y Z Pan
The lamina cribrosa (LC) is believed to be site of injury to retina ganglion cell axons in glaucoma. The ability to visualize this structure helps us increase the understanding of pathophysiological process of glaucoma. At the same time, it is helpful in the early detection and treatment of glaucoma. While for many years the researches on the LC were essentially dependent on histology. With the development of optical coherence tomography (OCT) in recent years, it is possible to image the LC in vivo in both animals and human...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27977479/pilot-study-of-lamina-cribrosa-intensity-measurements-in-glaucoma-using-swept-source-optical-coherence-tomography
#19
Sowmya Srinivas, Anna Dastiridou, Mary K Durbin, Muneeswar G Nittala, Alex A Huang, James C H Tan, Brian A Francis, Srinivas R Sadda, Vikas Chopra
PURPOSE: To compare the lamina cribrosa (LC) intensity in glaucoma-suspect eyes and eyes with mild to moderate glaucoma using swept-source optical coherence tomography. METHODS: Optic disc volume scans were collected using swept-source optical coherence tomography in 19 clinically defined glaucoma-suspect eyes and 29 eyes with mild to moderate glaucoma. LC intensity was measured using Image J software, and the resultant values were normalized using the retinal pigment epithelium and vitreous signal...
February 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/27935604/ocular-characteristics-associated-with-the-location-of-focal-lamina-cribrosa-defects-in-open-angle-glaucoma-patients
#20
H-Yl Park, Y S Hwang, C K Park
PurposeTo investigate the clinical characteristics according to the location of focal lamina cribrosa (LC) defects and its associated ocular features.Patients and methodsA total of 139 open-angle glaucoma patients underwent Spectralis optical coherence tomography (OCT) with enhanced depth imaging. Alterations in the contour of the LC were investigated to find focal LC defects. The location of the visible LC defect from the neural canal wall (far-peripheral and mid-peripheral) and clock-hour position (superotemporal, temporal and inferotemporal) were classified...
December 9, 2016: Eye
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