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Acetogenins AND Cancer

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https://www.readbyqxmd.com/read/30151067/anticancer-properties-of-graviola-annona-muricata-a-comprehensive-mechanistic-review
#1
REVIEW
Islam Rady, Melissa B Bloch, Roxane-Cherille N Chamcheu, Sergette Banang Mbeumi, Md Rafi Anwar, Hadir Mohamed, Abiola S Babatunde, Jules-Roger Kuiate, Felicite K Noubissi, Khalid A El Sayed, G Kerr Whitfield, Jean Christopher Chamcheu
Graviola ( Annona muricata ) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in tropical and subtropical regions around the world. The aerial parts of graviola have several functions: the fruits have been widely used as food confectionaries, while several preparations, especially decoctions of the bark, fruits, leaves, pericarp, seeds, and roots, have been extensively used in traditional medicine to treat multiple ailments including cancers by local communities in tropical Africa and South America...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30105068/-annona-muricata-leaf-extract-triggered-intrinsic-apoptotic-pathway-to-attenuate-cancerous-features-of-triple-negative-breast-cancer-mda-mb-231-cells
#2
Jee Young Kim, Thien T P Dao, Kwangho Song, Sait Byul Park, Hyeri Jang, Min Kyoung Park, Soo Ueng Gan, Yeong Shik Kim
Annona muricata L., known as graviola, is an evergreen plant of the tropical regions and is a rich source of natural products. Graviola has various biological activities, and it is best known for its anticancer activity. This study aimed to investigate the effects of crude graviola extract in vitro on breast cancer cells; in particular, we aimed to identify an agent against triple negative breast cancer (TNBC). We used the TNBC MDA-MB-231 cell line as the experimental model and the ER(+) non-TNBC MCF-7 breast cancer cell line as the control...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29988040/annonacin-promotes-selective-cancer-cell-death-via-nka-dependent-and-serca-dependent-pathways
#3
Andreas Yiallouris, Ioannis Patrikios, Elizabeth O Johnson, Evangelia Sereti, Konstantinos Dimas, Cristian De Ford, Natalia U Fedosova, Wolfgang F Graier, Kleitos Sokratous, Kyriakos Kyriakou, Anastasis Stephanou
In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and to exhibit anticancer effects. Graviola tree is an evergreen tree with its extracts (leafs and seeds) been reported having anticancer properties, but the precise target of action is not clear. Using an in silico approach, we predicted that annonacin, an Acetogenin, the active agent found in Graviola leaf extract (GLE) to potentially act as a novel inhibitor of both sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps...
July 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29973884/exploring-the-leaves-of-annona-muricata-l-as-a-source-of-potential-anti-inflammatory-and-anticancer-agents
#4
REVIEW
Siti Mariam Abdul Wahab, Ibrahim Jantan, Md Areeful Haque, Laiba Arshad
The use of anti-inflammatory natural products to treat inflammatory disorders for cancer prevention and therapy is an appealing area of interest in the last decades. Annona muricata L. is one of the many plant extracts that have been explored owing to their anti-inflammatory and anticancer effects. Different parts of A. muricata especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, and abscesses...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29933016/potential-therapeutic-applications-of-the-genus-annona-local-and-traditional-uses-and-pharmacology
#5
REVIEW
A M Quílez, M A Fernández-Arche, M D García-Giménez, R De la Puerta
ETHNO-PHARMACOLOGICAL RELEVANCE: Annona species (Annonaceae) have long been used as traditional herbal medicines by native peoples in tropical areas. In different countries they are used against a large variety of illnesses, such as parasitic and infectious diseases, cancer, diabetes, peptic ulcers, and mental disorders. AIM OF THE STUDY: This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species...
October 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29921883/annonaceous-acetogenin-mimic-aa005-suppresses-human-colon-cancer-cell-growth-in-vivo-through-downregulation-of-mcl-1
#6
Bing Han, Yu-Xia Cao, Zhan-Ming Li, Zhao-Xia Wu, Yu-Qin Mao, Hui-Ling Chen, Zhu-Jun Yao, Li-Shun Wang
Annonaceous acetogenins are a well-established family of natural products with significant bioactivities, especially high cytotoxic and antitumor activities. AA005 is an annonaceous acetogenin mimic that has shown significant cytotoxicity against a variety of cancer cell lines, but its in vivo antitumor effects have not been demonstrated so far, and its anticancer mechanisms remain ambiguous. In this study, we investigated the effects of AA005 on human colon cancer cell lines in vivo. Human colon carcinoma cell line SW620 xenograft nude mice were treated with AA005 (5 mg/kg/day, i...
June 19, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29914183/graviola-annona-muricata-exerts-anti-proliferative-anti-clonogenic-and-pro-apoptotic-effects-in-human-non-melanoma-skin-cancer-uw-bcc1-and-a431-cells-in-vitro-involvement-of-hedgehog-signaling
#7
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N Chamcheu, Abu Bakar Siddique, Melissa B Bloch, Sergette Banang Mbeumi, Abiola S Babatunde, Mohammad B Uddin, Felicite K Noubissi, Peter W Jurutka, Yong-Yu Liu, Vladimir S Spiegelman, G Kerr Whitfield, Khalid A El Sayed
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola ( Annona muricata ), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29750943/metabolomics-analysis-of-the-potential-anticancer-mechanism-of-annonaceous-acetogenins-on-a-multidrug-resistant-mammary-adenocarcinoma-cell
#8
Chengyao Ma, Yue Li, Hanqing Wu, Junyang Ji, Qianqian Sun, Yilin Song, Shen Wang, Xiang Li, Yong Chen, Jianwei Chen
Although annonaceous acetogenins (ACGs) have been reported to have antitumor activity for over three decades, and many of the underlying mechanism of ACGs on cancer have been clarified, there are still outstanding issues. In particular, the changes of small metabolite in cancer cells, caused by ACGs intake, have been reported rarely. Recent research has showed that cellular metabolic profiling coupled with ultra-flow liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UFLC-Q-TOF-MS) and multivariable statistical analysis enables a good understanding of ACGs' effects on multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells...
July 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29660776/correlation-between-acetogenin-content-and-antiproliferative-activity-of-pawpaw-asimina-triloba-l-dunal-fruit-pulp-grown-in-korea
#9
Jin-Sik Nam, Seo-Yeon Park, Hyo-Jeong Lee, Seon-Ok Lee, Hye-Lim Jang, Young Ha Rhee
Pawpaw (Asimina triloba [L.] Dunal) is widely cultivated in Korea for its fruit, which contains bioactive compounds, such as acetogenins. In this study, we investigated the acetogenin content and antiproliferative activity of pawpaw fruit pulp against various cancer cell lines and evaluated the relationship between these two variables at different maturation stages. Unripe fruit had higher antiproliferative activity than ripe fruit, and the activity level depended on acetogenin content. In addition, the presence of specific acetogenins was related to inhibition of certain cancer cell types...
May 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29462271/emerging-therapeutic-potential-of-graviola-and-its-constituents-in-cancers
#10
Asif Khurshid Qazi, Jawed A Siddiqui, Rahat Jahan, Sanjib Chaudhary, Larry A Walker, Zafar Sayed, Dwight T Jones, Surinder K Batra, Muzafar A Macha
Cancer remains a leading cause of death in the USA and around the world. Although the current synthetic inhibitors used in targeted therapies have improved patient prognosis, toxicity and development of resistance to these agents remain a challenge. Plant-derived natural products and their derivatives have historically been used to treat various diseases, including cancer. Several leading chemotherapeutic agents are directly or indirectly based on botanical natural products. Beyond these important drugs, however, a number of crude herbal or botanical preparations have also shown promising utility for cancer and other disorders...
April 5, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29430581/plagioneurin-b-a-potent-isolated-compound-induces-apoptotic-signalling-pathways-and-cell-cycle-arrest-in-ovarian-cancer-cells
#11
Noraziah Nordin, Nazia Abdul Majid, Rozana Othman, Fatima Abdelmutaal Ahmed Omer, Muhammad Nazil Afiq Nasharuddin, Najihah Mohd Hashim
Plagioneurin B belongs to acetogenin group has well-established class of compounds. Acetogenin group has attracted worldwide attention in the past few years due their biological abilities as inhibitors for several types of tumour cells. Plagioneurin B was isolated via conventional chromatography and tested for thorough mechanistic apoptosis activity on human ovarian cancer cells (CAOV-3). Its structure was also docked at several possible targets using Autodock tools software. Our findings showed that plagioneurin B successfully inhibits the growth of CAOV-3 cells at IC50 of 0...
February 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29204721/molecular-docking-studies-of-bioactive-compounds-from-annona-muricata-linn-as-potential-inhibitors-for-bcl-2-bcl-w-and-mcl-1-antiapoptotic-proteins
#12
Mohamad Norisham Mohamad Rosdi, Shahkila Mohd Arif, Mohamad Hafizi Abu Bakar, Siti Aisyah Razali, Razauden Mohamed Zulkifli, Harisun Ya'akob
Annona muricata Linn or usually identified as soursop is a potential anticancer plant that has been widely reported to contain valuable chemopreventive agents known as annonaceous acetogenins. The antiproliferative and anticancer activities of this tropical and subtropical plant have been demonstrated in cell culture and animal studies. A. muricata L. exerts inhibition against numerous types of cancer cells, involving multiple mechanism of actions such as apoptosis, a programmed cell death that are mainly regulated by Bcl-2 family of proteins...
January 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29080611/annona-muricata-is-the-natural-therapy-to-most-disease-conditions-including-cancer-growing-in-our-backyard-a-systematic-review-of-its-research-history-and-future-prospects
#13
REVIEW
Yahaya Gavamukulya, Fred Wamunyokoli, Hany A El-Shemy
Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many medicinal uses. This review focuses on the research history of its traditional uses, phytochemicals, pharmacological activities, toxicological aspects of the extracts and isolated compounds, as well as the in vitro propagation studies with the objective of stimulating further studies on this plant for human consumption and treatment. A. muricata extracts have been identified in tropical regions to traditionally treat diverse conditions ranging from fever to diabetes and cancer...
September 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28487731/the-value-of-caspase-3-after-the-application-of-annona-muricata-leaf-extract-in-colo-205-colorectal-cancer-cell-line
#14
Murdani Abdullah, Ari Fahrial Syam, Sofy Meilany, Bayu Laksono, Oryza Gryagus Prabu, Heri Setiyo Bekti, Lili Indrawati, Dadang Makmun
Annona muricata, commonly known as soursop, contains annonacin, acetogenin, and polyphenol which are known to have chemopreventive effects on cancer. In this study, we tend to evaluate the apoptosis-inducing effect of soursop (Annona muricata) leaf extract on the colorectal cancer cell line COLO-205 through the activities of caspase-3 which is a marker of cell apoptosis. Cell cultures were incubated with soursop leaf with a concentration of 10 μg/ml and then compared with those of the incubated positive control leucovorin 10 μg/ml and placebo as a negative control...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28416750/annonaceous-acetogenins-mediated-up-regulation-of-notch2-exerts-growth-inhibition-in-human-gastric-cancer-cells-in-vitro
#15
Yan Li, Jianbin Ye, Zhongbiao Chen, Junjie Wen, Fei Li, Pengpeng Su, Yanqing Lin, Bingxin Hu, Danlin Wu, Lijun Ning, Qi Xue, Hongxiang Gu, Yunshan Ning
BACKGROUND: Gastric cancer (GC) is a global health problem because of limited treatments and poor prognosis. Annonaceous acetogenins (ACGs) has been reported to exert anti-tumorigenic effects in cancer, yet the mechanism underlying its effects on GC remains largely unknown. Notch signaling plays a critical role in cell proliferation, differentiation and apoptosis. Therefore, it may contribute to the development of GC. This study aims to explore the role of Notch2 in ACGs' activities in GC cells...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28116099/a-novel-thiophene-3-carboxamide-analog-of-annonaceous-acetogenin-exhibits-antitumor-activity-via-inhibition-of-mitochondrial-complex-i
#16
Akinobu Akatsuka, Naoto Kojima, Mutsumi Okamura, Shingo Dan, Takao Yamori
Previously we synthesized JCI-20679, a novel thiophene-3-carboxamide analog of annonaceous acetogenins which have shown potent antitumor activity, with no serious side effects, in mouse xenograft models. In this study, we investigated the antitumor mechanism of JCI-20679. The growth inhibition profile (termed "fingerprint") of this agent across a panel of 39 human cancer cell lines (termed "JFCR39") was measured; this fingerprint was analyzed by the COMPARE algorithm utilizing the entire drug sensitivity database for the JFCR39 panel...
August 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28064519/three-new-antitumor-annonaceous-acetogenins-from-the-seeds-of-annona-squamosa
#17
Chengyao Ma, Qiwen Wang, Yeye Shi, Yue Li, Xunan Wang, Xiang Li, Yong Chen, Jianwei Chen
Two new annonaceous acetogenins squamocin P (2) and annosquatin III (3) and one new ACG precursor dieporeticenin B (1) along with five known precursors (4-8) were isolated from the seeds of Annona squamosa. Their structures were ascertained by chemical methods and various spectral evidences. These compounds showed inhibitory effects against three multidrug-resistant (MDR) cancer cell lines. Compound 2 and 3 displayed selective cytotoxicity against SMMC 7721/T (IC50 0.435 and 1.79 μM) and MCF-7/ADR (IC50 values 3...
September 2017: Natural Product Research
https://www.readbyqxmd.com/read/27566205/antitumor-activity-of-annona-squamosa-seed-oil
#18
Yong Chen, Yayun Chen, Yeye Shi, Chengyao Ma, Xunan Wang, Yue Li, Yunjie Miao, Jianwei Chen, Xiang Li
CONTEXT: Custard apple (Annona squamosa Linn.) is an edible tropical fruit, and its seeds have been used to treat "malignant sore" (cancer) and other usage as insecticide. A comparison of extraction processes, chemical composition analysis and antitumor activity of A. squamosa seed oil (ASO) were investigated. MATERIALS AND METHODS: The optimal extraction parameters of ASO were established by comparing percolation, soxhlet, ultrasonic and SFE-CO2 extraction methods...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27533261/short-route-to-the-total-synthesis-of-natural-muricadienin-and-investigation-of-its-cytotoxic-properties
#19
Usein M Dzhemilev, Vladimir A D'yakonov, Regina A Tuktarova, Lilya U Dzhemileva, Svetlana R Ishmukhametova, Milyausha M Yunusbaeva, Armin de Meijere
An original synthesis of the acetogenin muricadienin, the bioprecursor of solamin, has been developed. The key step in the five-step 41% overall yield synthesis is the catalytic cross-cyclomagnesiation reaction of functionally substituted 1,2-dienes with EtMgBr in the presence of Cp2TiCl2 and magnesium metal. It has been demonstrated for the first time that muricadienin exhibits a moderate in vitro inhibitory activity against topoisomerases I and IIα, key cell cycle enzymes. Using flow cytometry, muricadienin was shown to have high cytotoxicity toward the HEK293 kidney cancer cells (IC50 0...
August 26, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27486323/annonaceous-acetogenins-nanosuspensions-stabilized-by-pcl-peg-block-polymer-significantly-improved-antitumor-efficacy
#20
Jingyi Hong, Yanhong Li, Yijing Li, Yao Xiao, Haixue Kuang, Xiangtao Wang
Annonaceous acetogenins (ACGs) have shown superior antitumor activity against a variety of cancer cell lines, but their clinical application has been limited by their poor solubility. In this study, ACGs-nanosuspensions (NSps) were successfully prepared by a precipitation ultrasonic method using monomethoxypoly (ethylene glycol)2000-poly (ε-caprolactone)2000 (mPEG2000-PCL2000) as a stabilizer. The resultant ACGs-NSps had a mean particle size of 123.2 nm, a zeta potential of -20.17 mV, and a high drug payload of 73...
2016: International Journal of Nanomedicine
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