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Acetogenins

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https://www.readbyqxmd.com/read/30151067/anticancer-properties-of-graviola-annona-muricata-a-comprehensive-mechanistic-review
#1
REVIEW
Islam Rady, Melissa B Bloch, Roxane-Cherille N Chamcheu, Sergette Banang Mbeumi, Md Rafi Anwar, Hadir Mohamed, Abiola S Babatunde, Jules-Roger Kuiate, Felicite K Noubissi, Khalid A El Sayed, G Kerr Whitfield, Jean Christopher Chamcheu
Graviola ( Annona muricata ) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in tropical and subtropical regions around the world. The aerial parts of graviola have several functions: the fruits have been widely used as food confectionaries, while several preparations, especially decoctions of the bark, fruits, leaves, pericarp, seeds, and roots, have been extensively used in traditional medicine to treat multiple ailments including cancers by local communities in tropical Africa and South America...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30105068/-annona-muricata-leaf-extract-triggered-intrinsic-apoptotic-pathway-to-attenuate-cancerous-features-of-triple-negative-breast-cancer-mda-mb-231-cells
#2
Jee Young Kim, Thien T P Dao, Kwangho Song, Sait Byul Park, Hyeri Jang, Min Kyoung Park, Soo Ueng Gan, Yeong Shik Kim
Annona muricata L., known as graviola, is an evergreen plant of the tropical regions and is a rich source of natural products. Graviola has various biological activities, and it is best known for its anticancer activity. This study aimed to investigate the effects of crude graviola extract in vitro on breast cancer cells; in particular, we aimed to identify an agent against triple negative breast cancer (TNBC). We used the TNBC MDA-MB-231 cell line as the experimental model and the ER(+) non-TNBC MCF-7 breast cancer cell line as the control...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30077947/targeted-and-non-targeted-analysis-of-annonaceous-alkaloids-and-acetogenins-from-asimina-and-annona-species-using-uhplc-qtof-ms
#3
Bharathi Avula, Ji-Yeong Bae, Taghreed Majrashi, Tung-Ying Wu, Yan-Hong Wang, Mei Wang, Zulfiqar Ali, Yang-Chang Wu, Ikhlas A Khan
In current work, targeted and non-targeted analysis of alkaloids and acetogenins from methanolic extracts of Asimina, Annona species and dietary supplements have been performed using UHPLC-QToF in positive ion mode. Thirty-five standard compounds (twelve alkaloids and twenty-three acetogenins) were used for the analysis. The fragment ions produced by collision induced dissociation (CID) revealed the characteristic cleavage and provided structural information. Aporphine alkaloids and acetogenins are the major groups found in Asimina and Annona species...
September 10, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/30028612/antiangiogenic-activity-and-chemical-derivatization-of-the-neurotoxic-acetogenin-annonacin-isolated-from-asimina-triloba
#4
Paige J Monsen, Frederick A Luzzio
Annonacin (1) was isolated from the North American pawpaw ( Asimina triloba), as reported earlier from these laboratories. Natural 1 was submitted to the rat aortic ring bioassay for evaluation of antiangiogenic activity and was found to inhibit microvessel growth (IC50 value of 3 μM). 4,10,15,20-Tetraazido derivatives of 1 were prepared by permesylation followed by azide displacement or by iodination followed by azide displacement. The tetraazide derived from mesylation/azidation was antiangiogenic, while that derived from iodination/azidation exhibited no appreciable activity...
August 24, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29988040/annonacin-promotes-selective-cancer-cell-death-via-nka-dependent-and-serca-dependent-pathways
#5
Andreas Yiallouris, Ioannis Patrikios, Elizabeth O Johnson, Evangelia Sereti, Konstantinos Dimas, Cristian De Ford, Natalia U Fedosova, Wolfgang F Graier, Kleitos Sokratous, Kyriakos Kyriakou, Anastasis Stephanou
In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and to exhibit anticancer effects. Graviola tree is an evergreen tree with its extracts (leafs and seeds) been reported having anticancer properties, but the precise target of action is not clear. Using an in silico approach, we predicted that annonacin, an Acetogenin, the active agent found in Graviola leaf extract (GLE) to potentially act as a novel inhibitor of both sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps...
July 9, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29973884/exploring-the-leaves-of-annona-muricata-l-as-a-source-of-potential-anti-inflammatory-and-anticancer-agents
#6
REVIEW
Siti Mariam Abdul Wahab, Ibrahim Jantan, Md Areeful Haque, Laiba Arshad
The use of anti-inflammatory natural products to treat inflammatory disorders for cancer prevention and therapy is an appealing area of interest in the last decades. Annona muricata L. is one of the many plant extracts that have been explored owing to their anti-inflammatory and anticancer effects. Different parts of A. muricata especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, and abscesses...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29933016/potential-therapeutic-applications-of-the-genus-annona-local-and-traditional-uses-and-pharmacology
#7
REVIEW
A M Quílez, M A Fernández-Arche, M D García-Giménez, R De la Puerta
ETHNO-PHARMACOLOGICAL RELEVANCE: Annona species (Annonaceae) have long been used as traditional herbal medicines by native peoples in tropical areas. In different countries they are used against a large variety of illnesses, such as parasitic and infectious diseases, cancer, diabetes, peptic ulcers, and mental disorders. AIM OF THE STUDY: This review aims to achieve a comprehensive understanding of the research conducted so far on the local and traditional uses, pharmacological activities, mechanism of actions of active compounds, toxicity, and possible interactions with other drugs of the Annona species...
October 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29921883/annonaceous-acetogenin-mimic-aa005-suppresses-human-colon-cancer-cell-growth-in-vivo-through-downregulation-of-mcl-1
#8
Bing Han, Yu-Xia Cao, Zhan-Ming Li, Zhao-Xia Wu, Yu-Qin Mao, Hui-Ling Chen, Zhu-Jun Yao, Li-Shun Wang
Annonaceous acetogenins are a well-established family of natural products with significant bioactivities, especially high cytotoxic and antitumor activities. AA005 is an annonaceous acetogenin mimic that has shown significant cytotoxicity against a variety of cancer cell lines, but its in vivo antitumor effects have not been demonstrated so far, and its anticancer mechanisms remain ambiguous. In this study, we investigated the effects of AA005 on human colon cancer cell lines in vivo. Human colon carcinoma cell line SW620 xenograft nude mice were treated with AA005 (5 mg/kg/day, i...
June 19, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29914183/graviola-annona-muricata-exerts-anti-proliferative-anti-clonogenic-and-pro-apoptotic-effects-in-human-non-melanoma-skin-cancer-uw-bcc1-and-a431-cells-in-vitro-involvement-of-hedgehog-signaling
#9
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N Chamcheu, Abu Bakar Siddique, Melissa B Bloch, Sergette Banang Mbeumi, Abiola S Babatunde, Mohammad B Uddin, Felicite K Noubissi, Peter W Jurutka, Yong-Yu Liu, Vladimir S Spiegelman, G Kerr Whitfield, Khalid A El Sayed
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola ( Annona muricata ), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29873386/scope-of-the-2-5h-furanone-helicity-rule-a-combined-ecd-vcd-and-dft-investigation
#10
Fernando M Dos Santos Jr, Keylla U Bicalho, Ítalo H Calisto, Gabriel S Scatena, João B Fernandes, Quezia B Cass, João M Batista Jr
One of the most widely used methods to assess the stereochemistry of chiral 2(5H)-furanones is an empirical electronic circular dichroism (ECD) helicity rule. In the present work, an extensive experimental and theoretical investigation of the scope of the above-mentioned empirical rule for acetogenins with a hydroxyl group substituted at C-4 revealed a possible exception to this rule. The underlying causes for this observation are discussed with respect to side chain substitutions, conformational requirements, chromophore handedness as well as a qualitative orbital analysis...
June 20, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29750943/metabolomics-analysis-of-the-potential-anticancer-mechanism-of-annonaceous-acetogenins-on-a-multidrug-resistant-mammary-adenocarcinoma-cell
#11
Chengyao Ma, Yue Li, Hanqing Wu, Junyang Ji, Qianqian Sun, Yilin Song, Shen Wang, Xiang Li, Yong Chen, Jianwei Chen
Although annonaceous acetogenins (ACGs) have been reported to have antitumor activity for over three decades, and many of the underlying mechanism of ACGs on cancer have been clarified, there are still outstanding issues. In particular, the changes of small metabolite in cancer cells, caused by ACGs intake, have been reported rarely. Recent research has showed that cellular metabolic profiling coupled with ultra-flow liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry (UFLC-Q-TOF-MS) and multivariable statistical analysis enables a good understanding of ACGs' effects on multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells...
July 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29660776/correlation-between-acetogenin-content-and-antiproliferative-activity-of-pawpaw-asimina-triloba-l-dunal-fruit-pulp-grown-in-korea
#12
Jin-Sik Nam, Seo-Yeon Park, Hyo-Jeong Lee, Seon-Ok Lee, Hye-Lim Jang, Young Ha Rhee
Pawpaw (Asimina triloba [L.] Dunal) is widely cultivated in Korea for its fruit, which contains bioactive compounds, such as acetogenins. In this study, we investigated the acetogenin content and antiproliferative activity of pawpaw fruit pulp against various cancer cell lines and evaluated the relationship between these two variables at different maturation stages. Unripe fruit had higher antiproliferative activity than ripe fruit, and the activity level depended on acetogenin content. In addition, the presence of specific acetogenins was related to inhibition of certain cancer cell types...
May 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29608108/folate-targeting-annonaceous-acetogenins-nanosuspensions-significantly-enhanced-antitumor-efficacy-in-hela-tumor-bearing-mice
#13
Haowen Li, Yijing Li, Hui Ao, Dongdong Bi, Meihua Han, Yifei Guo, Xiangtao Wang
Annonaceous acetogenins (ACGs) are one of the most active constituents isolated from Annona species with potent antitumor activity. However, the poor solubility and severe side effect greatly limit their use in clinic. In this study, folic acid (FA) modified annonaceous acetogenins nanosuspensions (FA-PEG-ACGs-NSps) had been successfully prepared using DSPE-PEG-FA and soybean lecithin (SPC) as stabilizers. The resultant FA-PEG-ACGs-NSps had a mean particle size of 119.7 nm, a zeta potential of -23.0 mV and a high drug payload of 49...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29561818/new-metabolites-isolated-from-a-laurencia-obtusa-population-collected-in-corsica
#14
Hélène Esselin, Félix Tomi, Ange Bighelli, Sylvain Sutour
The chemical investigation of an ethyl acetate extract (EtOAc) obtained from Laurencia obtusa , collected in Corsica, allowed for the identification of three new compounds ( 1 , 2 , and 4 ) and six known compounds. Compounds 1 to 4 were isolated and fully characterized by a detailed spectroscopic analysis. Compounds 1 and 2 are two C15 -acetogenins sharing the same ring system: a tetrahydropyran linked by a methylene to a tetrahydrofuran ring. Compound 1 exhibits a bromoallene unit whereas compound 2 possesses an uncommon α-bromo-α,β-unsaturated aldehyde terminal unit...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29524778/squamocin-induce-histological-and-ultrastructural-changes-in-the-midgut-cells-of-anticarsia-gemmatalis-lepidoptera-noctuidae
#15
Muhammad Fiaz, Luis Carlos Martínez, Marilza da Silva Costa, Jamile Fernanda Silva Cossolin, Angelica Plata-Rueda, Wagner Gonzaga Gonçalves, Antônio Euzébio Goulart Sant'Ana, José Cola Zanuncio, José Eduardo Serrão
Annonaceous acetogenins (Annona squamosa Linnaeus) comprises of a series of natural products which are extracted from Annonaceae species, squamocin proved to be highly efficient among those agents. Squamocin is mostly referred as a lethal agent for midgut cells of different insects, with toxic effects when tested against larva of some insects. In present study, LC50 and LC90 of squamocin for A. gemmatalis Hübner (Lepidoptera: Noctuidae) were calculated using probit analysis. Morphological changes in midgut cells were analyzed under light, fluorescence and transmission electron microscopes when larvae were treated with LC50 and LC90 of squamocin for 24, 48 and 72 h...
July 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29462271/emerging-therapeutic-potential-of-graviola-and-its-constituents-in-cancers
#16
Asif Khurshid Qazi, Jawed A Siddiqui, Rahat Jahan, Sanjib Chaudhary, Larry A Walker, Zafar Sayed, Dwight T Jones, Surinder K Batra, Muzafar A Macha
Cancer remains a leading cause of death in the USA and around the world. Although the current synthetic inhibitors used in targeted therapies have improved patient prognosis, toxicity and development of resistance to these agents remain a challenge. Plant-derived natural products and their derivatives have historically been used to treat various diseases, including cancer. Several leading chemotherapeutic agents are directly or indirectly based on botanical natural products. Beyond these important drugs, however, a number of crude herbal or botanical preparations have also shown promising utility for cancer and other disorders...
April 5, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29430581/plagioneurin-b-a-potent-isolated-compound-induces-apoptotic-signalling-pathways-and-cell-cycle-arrest-in-ovarian-cancer-cells
#17
Noraziah Nordin, Nazia Abdul Majid, Rozana Othman, Fatima Abdelmutaal Ahmed Omer, Muhammad Nazil Afiq Nasharuddin, Najihah Mohd Hashim
Plagioneurin B belongs to acetogenin group has well-established class of compounds. Acetogenin group has attracted worldwide attention in the past few years due their biological abilities as inhibitors for several types of tumour cells. Plagioneurin B was isolated via conventional chromatography and tested for thorough mechanistic apoptosis activity on human ovarian cancer cells (CAOV-3). Its structure was also docked at several possible targets using Autodock tools software. Our findings showed that plagioneurin B successfully inhibits the growth of CAOV-3 cells at IC50 of 0...
February 2018: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29381359/halogenated-c-15-acetogenin-analogues-of-obtusallene-iii-from-a-laurenciella-sp-collected-in-corsica
#18
Sylvain Sutour, Bruno Therrien, Stephan H von Reuss, Félix Tomi
NMR chemical profiling of a Laurenciella sp. using a computerized method developed in our laboratory resulted in the identification of five new compounds (1-5) and 17 known compounds, among which 3-(E)-laurenyne represented by far the most abundant metabolite. Compounds 1 to 5 were isolated and fully characterized by detailed spectroscopic analysis. The absolute configuration and structural features of compound 1 were determined by single-crystal X-ray diffraction analysis. Compounds 1 to 4 are 12-membered cyclic ether acetogenins that are present in solution as interconverting conformers exhibiting an (aR) configuration of the bromoallene unit together with an S configuration at C-4...
February 23, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29286293/pinnatifidenyne-derived-ethynyl-oxirane-acetogenins-from-laurencia-viridis
#19
Adrián Morales-Amador, Caterina R de Vera, Olivia Márquez-Fernández, Antonio Hernández Daranas, José M Padrón, José J Fernández, María L Souto, Manuel Norte
Red algae of Laurencia continue to provide wide structural diversity and complexity of halogenated C15 acetogenin medium-ring ethers. Here, we described the isolation of three new C15 acetogenins ( 3 - 5 ), and one truncated derivative ( 6 ) from Laurencia viridis collected on the Canary Islands. These compounds are interesting variations on the pinnatifidenyne structure that included the first examples of ethynyl oxirane derivatives ( 3 - 4 ). The structures were elucidated by extensive study of NMR (Nuclear Magnetic Resonance) data, J -based configuration analysis and DFT (Density Functional Theory) calculations...
December 29, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29281900/nangallenes-a-and-b-halogenated-nonterpenoid-c-15-acetogenins-from-the-bornean-red-alga-laurencia-nangii
#20
Takashi Kamada, Chin-Soon Phan, Charles S Vairappan
Two new halogenated nonterpenoids C15 -acetogenins, nangallenes A-B (1-2), together with two known halogenated compounds itomanallene A (3) and 2,10-dibromo-3-chloro-α-chamigrene (4), were isolated and identified from the organic extract of the marine red alga Laurencia nangii Masuda collected from the coastal waters in Semporna, Borneo. Their structures were established by means of spectroscopic analysis including IR, high-resolution electrospray ionization mass spectrometry (HRESI-MS), and 1D and 2D NMR techniques...
December 27, 2017: Journal of Asian Natural Products Research
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