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anal cancer and hepatic metastases

Xuetong Jiang, Chuanqi Xu, Dong Tang, Daorong Wang
Synchronous colorectal cancers refer to the simultaneous occurrence of multiple colorectal tumors in a single patient, excluding any metastases from other organs. At present, radical surgery is considered the standard curative treatment; however, individualized surgical strategies depend on tumor location, the depth of invasion and the general health of the patient. In the present study, the case of a 52-year-old man who presented with a 2-month history of abdominal pain that was accompanied by intermittent hematochezia and weight loss is reported...
August 2016: Oncology Letters
C Ostheimer, F Meyer, C Kornhuber, T Reese, D Vordermark
Radiooncological therapies are an integral part of the multimodal oncological treatment concepts in general and abdominal surgery. These include therapeutic approaches with a curative intention such as the neoadjuvant (pre-operative) radiotherapy of locoregionally advanced and/or N+ oesophageal and rectal cancer, definitive combined chemoradiotherapy of locally advanced, unresectable oesophageal cancer or oesophageal tumour lesions of the upper third, definitive radiotherapy of anal cancer (sphincter sparing) and pre- or post-operative radiotherapy of soft tissue sarcoma on the one hand...
February 2015: Zentralblatt Für Chirurgie
Oo Ayandipo, DO Irabor, Oo Afuwape, Jk Ladipo, Ai Abdurrazzaaq
BACKGROUND: Colonic tumours are the third most common tumours in the Nigerian cancer registry after breast and cervical carcinoma. Tumours involving the distal rectum and anus are increasingly a significant portion of all colorectal and anal malignancies in Nigeria. The patients frequently present with advanced disease. Abdomino-Perineal resection (APR), is thus an essential modality of treatment alongside chemo-radiation. The aim of the study was to review the surgical outcomes of APR done for low rectal and anal malignancies in a resource poor setting in sub-Saharan Africa...
July 2013: Journal of the West African College of Surgeons
Ninoska N Silva, Cathy Eng
Case Study Ms. S.G., a 56-year-old woman with a poorly differentiated squamous cell carcinoma of the anal canal, American Joint Committee on Cancer stage III (T2, N1, M0), was initially diagnosed in December, 2007 at an outside institution after she had noted blood in her stool for approximately 6 months. Her medical history was unremarkable. She had no known history of HIV or other sexually transmitted diseases. At the time of presentation, Ms. S.G. had an Eastern Cooperative Oncology Group performance status of 1 related to cancer-related pain...
May 2012: Journal of the Advanced Practitioner in Oncology
Ziman Zhu, Jing-Wang Tan, Hua-Min Tan, Ben-Shun Hu, Ke Chen, Xiang-Min Ding, Jian-Jun Leng, Fei Chen
BACKGROUND/AIMS: There is no consensus for laparoscopy first in patients with rectal cancer and synchronous liver metastases, whose metastases are confined to the liver. This study aimed to evaluate its indications for one-stage surgery in laparoscopy. MATERIALS AND METHODS: Eighteen patients with rectal cancer and synchronous liver metastases, who had undergone laparoscopic colorectal resection and simultaneous treatment for liver metastases, were retrospectively reviewed...
2013: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Bilal O Al-Jiffry, Owaid Al-Malki
We describe the treatment of a 46-year-old Saudi man with advanced stage liver metastatic neuroendocrine rectal cancer. The patient presented with a large liver lesion and rectal bleeding. He was cachectic, with a firm tender mass 20 mm above the anal verge. Computed tomography (CT) showed a mass 9.5 × 13 cm in size in the right hemi-liver, abutting the middle hepatic vein. The patient refused treatment, and consulted another hospital. After 3 months, he presented with the same symptoms in addition to delirium...
2013: World Journal of Surgical Oncology
Kazutoshi Kida, Atsushi Kawasaki, Kenji Mimatsu, Nobutada Fukino, Youichi Kuboi, Hisao Kano, Takatsugu Oida
We experienced a rare case of intussusception due to sigmoid colon cancer during chemotherapy. A-62-year-old female was started on mFOLFOX6 due to sigmoid colon cancer and hepatic metastases(stage IV). After 2 courses, she had abdominal pain and bloody stool. Abdominal ultrasonography showed a target sign, and abdominal CT showed edema of the mucosa of the sigmoid colon and invagination. She was diagnosed with intussusception due to sigmoid colon cancer, and underwent a bloodless reduction. However, because it was unavailable, we performed an emergency operation...
October 2012: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Ayako Tsumura, Shozo Yokoyama, Katsunari Takifuji, Tsukasa Hotta, Kenji Matsuda, Takashi Watanabe, Yasuyuki Mitani, Hiroki Yamaue
This report describes a case of rectal cancer with endoscopically observable white nodules caused by distal intramural lymphatic spread. A 57-year-old female presented to our hospital with frequent diarrhea and hemorrhoids. Computed tomography showed bilateral ovarian masses and three hepatic tumors diagnosed as rectal cancer metastases, and also showed multiple lymph node involvement. The patient was preoperatively diagnosed with stage IV rectal cancer. Colonoscopy demonstrated that primary rectal cancer existed 15 cm from the anal verge and that there were multiple white small nodules on the anal side of the primary tumor extending to the dentate line...
2012: World Journal of Surgical Oncology
Lie Wang, Hua Min Tan, Jing Wang Tan, Yajuan Chu, Xiang Min Ding, Jia Hong Dong
BACKGROUND/AIMS: Lapraoscopic era provided a new alternative for rectal cancer and synchronous liver metastases (RCLM). However, there is no established consensus for laparoscopy "first" for patients with RCLM, whose metastasis is confined to the liver. This study aimed to evaluate its indications for one-stage surgery in laparoscopy. METHODOLOGY: Sixteen patients with RCLM, who had undergone laparoscopic colorectal resection and simultaneous treatment for liver metastasis, were retrospectively reviewed...
March 2013: Hepato-gastroenterology
Annamaria Bochicchio, Alfredo Tartarone, Orazio Ignomirelli, Giuseppe Latorre, Rodolfo Cangiano, Giuseppina Gallucci, Mariarosa Coccaro, Elisa Feudale, Michele Aieta
Breast cancer usually metastasizes towards the lymph nodes, lung, bone, liver or brain; metastatic gastrointestinal involvement is rare and anal metastases are extremely rare. Necroscopic studies report a 6-18% incidence of extra-hepatic gastrointestinal metastases, and the most frequent sites of the GI tract involved are the stomach and the small intestine. We report a case with anal metastasis from breast cancer and a review of the associated literature.
March 2012: Future Oncology
Nobuhiro Nitori, Yutaro Kato, Ayu Kato, Tomoaki Deguchi, Akihiro Okada, Masayuki Kojima, Junko Kuroda, Tomohisa Kadomura, Keisuke Kubota, Nobuto Origuchi, Masato Fujisaki, Masaki Kitajima
We report a case of anal cancer in a 58-year-old woman who complained of narrow, bloody stools and anal pain. Physical examination revealed anal stenosis associated with a circular mass arising in the anal canal. Histological examination of biopsy specimens confirmed a diagnosis of moderately differentiated squamous cell carcinoma. Enhanced computed tomography revealed anal cancer invading the levator ani and the vagina, with lymph-node, multiple hepatic, and pulmonary metastases. The patient received two cycle of chemoradiotherapy with S-1 plus low-dose cisplatin with rest for 4 weeks, leading to complete response of the primary lesion and a partial response of the metastatic lesions...
November 2011: Anticancer Research
Michael Bødker Lauritzen, Jan Lindebjerg
A 77 year-old male presented a locally advanced small cell anal cancer and simultaneous hepatic and glandular deposits. Due to metastatic disease, chemotherapy with carboplatin and etoposide was the primary choice of treatment. Small cell cancer of the gastrointestinal tract exerts an aggressive clinical course with early metastases and a very poor prognosis. The diagnosis is based on careful histopathological examination and immunohistochemistry. Due to the aggressiveness of this tumor it is of great importance that the pathologist, the oncologist, and the surgeons are aware of this rare type of cancer...
September 19, 2011: Ugeskrift for Laeger
D C Damin, G C Tolfo, M A Rosito, B L Spiro, L M Kliemann
BACKGROUND: To assess the feasibility of the sentinel lymph node procedure in patients with rectal cancer extending to the anal canal. METHODS: Between January 2005 and April 2008, 15 patients with adenocarcinoma of the rectum with direct invasion of the anal canal and no clinical evidence of inguinal involvement were prospectively enrolled in the study. The sentinel node procedure consisted of a combination of preoperative radiocolloid lymphoscintigraphy and intraoperative detection of the inguinal sentinel node with a gamma probe...
June 2010: Techniques in Coloproctology
Rikio Matsumoto, Toru Kuroda, Hirofumi Yamada, Kumi Hasegawa, Yutaka Mamiya, Akira Kon
We examined efficacy and safety of bevacizumab (BV)+modified FOLFOX6 (mFOLFOX6) regimen for unresectable colorectal cancer. We had 16 patients: liver metastases 8, lung metastases 4, local recurrences 2, and lymph node metastases 2, as for evaluable lesions. The response rate was 46.6%, and disease control rate was 86.6%. Hepatic metastatectomy was done in two cases after PR response. There was 1 infusion related reaction case, 1 tumor bleeding and 1 anal fistula as the adverse events. In conclusion, the BV+mFOLFOX6 is one of the effective and feasible regimens for unresectable colorectal cancer...
November 2009: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Miroslav Stojanović, Goran Stanojević, Milan Radojković, Aleksandar Zlatić, Ljiljana Jeremić, Branko Branković, Milan Jovanović, Milos Kostov, Miodrag Zdravković, Dragan Milić
BACKGROUND/AIM: Surgical strategy for the treatment of resectable synchronous hepatic metastases of colorectal cancer (CRC) remains controversial. The aim of this study was to assess safety of simultaneous colon and liver rese cions and the direct effects of this type of treatment upon morbidity and mortality of the patients with synchronus hepatic metastases of CRC. METHODS: Intraoperative and postoperative data of 31 patients with simultaneous liver and colorectal resection were compared with the data of 51 patients who had undergone colon and hepatic resection in the staging setting...
February 2008: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Koji Tanaka, Shingo Noura, Masayuki Ohue, Yousuke Seki, Kunihito Gotou, Masaaki Motoori, Kentarou Kishi, Kou Takachi, Hidetoshi Eguchi, Terumasa Yamada, Isao Miyashiro, Hiroaki Ohigashi, Masahiko Yano, Osamu Ishikawa, Shingi Imaoka, Kouhei Murata, Masao Kameyama
We report a case of inguinal lymphorrhea cured by Lipiodol lymphangiography. The patient was a 80-year-old female who underwent an abdomino-perineal resection with lateral pelvic lymph node dissection and inguinal lymph node extraction for anal canal cancer. Histologically, the tumor was a poorly differentiated adenocarcinoma and considered to be stage IV (a2, n3 (+), P0, H3, M (-), cur C) in the Japanese classification of colorectal cancer. We recognized a lot of lymph node metastases in dissected lateral pelvic lymph node and inguinal lymph node...
November 2007: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Tomoko Seya, Noritake Tanaka, Seiichi Shinji, Emi Shinji, Kimiyoshi Yokoi, Koji Horiba, Yoshikazu Kanazawa, Takeshi Yamada, Yoshiharu Oaki, Takashi Tajiri
We report on a patient with rectal malignant melanoma. The patient was a 40-year-old man who complained of anal bleeding. His grandmother had died of pancreatic cancer and his mother had been operated for rectal cancer. Physical examination revealed a hard mass at the 12 o'clock position, 2 cm from the anal verge. A colonoscopic examination revealed an irregular surface mass, approximately 4.0 cm in size, located on the anterior wall of the lower rectum. A biopsy of the rectal tumor showed the proliferation of epithelioid cells with pleomorphic features...
October 2007: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
M Arru, L Aldrighetti, F Gremmo, M Ronzoni, E Angeli, R Caterini, G Ferla
Introduction. Intra-Arterial Hepatic Chemotherapy (IAHC) based on floxuridine (FUdR) infusion is an effective treatment for hepatic metastases from colorectal cancer. A percutaneously implanted intra-arterial device may overcome the surgical stress of the laparotomic placement allowing an increase in the number of patients treated by IAHC. The aim of the present study is the comparative analysis of surgical and percutaneous transaxillary approaches to implant the catheter into the hepatic artery (HA) for IAHC...
July 2000: Journal of Vascular Access
Andreas Meyer, Frank Bruns, Klaus Richter, Viktor Grünwald, Johann H Karstens
BACKGROUND: We report on a rare case of small cell cancer located at the anal canal. CASE REPORT: A 41-year old woman presented with locally advanced small cell anal cancer and simultaneous hepatic and pulmonal deposits. Due to metastatic disease, chemotherapy with etoposide and cisplatin was performed with mixed response after four cycles of chemotherapy. After application of two additional chemotherapy cycles, locally progressive disease occurred causing symptomatic bowel obstruction...
March 2007: Anticancer Research
Hiroshi Aoki, Shigeto Ishidoya, Akihiro Ito, Mareyuki Endoh, Toru Shimazui, Yoichi Arai
Small-cell carcinoma of the prostate (SCCP) is a rare entity. Many treatment modalities have been done, but thus far no uniform treatment has been clearly established. We carried out combination chemotherapy with gemcitabine, docetaxel, and carboplatin (GDC) regimen (for two patients with refractory SCCP. Case 1 involved a 53-year-old man diagnosed with SCCP after receiving hormone therapy for prostate cancer (stage D1). Six cycles of GDC chemotherapy was applied. Initially the primary site reduced according with a decline of neuro-specific enolase and with relief of the symptoms; however, bone disease occurred and he died of cancer 13 months after diagnosis of SCCP...
September 2006: International Journal of Urology: Official Journal of the Japanese Urological Association
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