keyword
MENU ▼
Read by QxMD icon Read
search

NSTI

keyword
https://www.readbyqxmd.com/read/29281190/hyperbaric-oxygen-therapy-as-an-adjuvant-to-source-control-in-necrotizing-soft-tissue-infections
#1
António Pedro Pinto Ferreira, Sérgio Santos Vide, Tiago David Fonseca Fernandes, Pedro Miguel Barata de Silva Coelho, Óscar Ferraz Camacho
INTRODUCTION: Necrotizing soft tissue infections (NSTI) are rare but potentially lethal disorders, and adequate management is time- and resource-demanding. This study aims to assess whether variations in the treatment modalities - surgery, hyperbaric oxygen (HBO₂) therapy and negative pressure wound therapy - had an impact on the length to definitive source control in NSTI patients who underwent HBO₂. METHODS: This is a retrospective study of all NSTI patients treated with hyperbaric oxygen therapy between March 2007 and May 2015 at Unidade Local de Saúde de Matosinhos (ULSM) Hyperbaric Unit...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29248883/necrotising-soft-tissue-infection-without-systemic-toxicity-in-a-patient-with-rheumatoid-arthritis-treated-with-tocilizumab
#2
Saki Manabe, Hidetaka Yanagi, Hideki Ozawa, Atsushi Takagi
A Japanese woman aged 76 years with rheumatoid arthritis treated with prednisolone and tocilizumab presented with a 2-day history of redness and pain in her right thigh. She was hospitalised with a primary diagnosis of cellulitis and antimicrobial therapy was initiated. She had been stable until the fourth day of admission, when the swelling of her right thigh rapidly worsened and demonstrated purpura; she was subsequently unable to walk because of the pain. A diagnosis of necrotising soft tissue infection (NSTI) was made and extensive debridement was performed...
December 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29211657/open-to-air-is-a-viable-option-for-initial-wound-care-in-necrotizing-soft-tissue-infection-that-allows-early-detection-of-recurrence-without-need-for-painful-dressing-changes-or-return-to-operating-room
#3
Derek Yang, April Davies, Bailey Burge, Phillip Watkins, Sharmila Dissanaike
BACKGROUND: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. We evaluated the feasibility of this approach from a pain control standpoint...
December 6, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29180205/effect-of-transfer-status-on-outcomes-for-necrotizing-soft-tissue-infections
#4
Angela M Ingraham, Hee Soo Jung, Amy E Liepert, Charles Warner-Hillard, Caprice C Greenberg, John E Scarborough
BACKGROUND: Whether patients with necrotizing soft tissue infections (NSTI) who presented to under-resourced hospitals are best served by immediate debridement or expedited transfer is unknown. We examined whether interhospital transfer status impacts outcomes of patients requiring emergency debridement for NSTI. METHODS AND MATERIALS: We conducted a retrospective review studying patients with an operative diagnosis of necrotizing fasciitis, Fournier's gangrene, or gas gangrene in the 2010-2015 American College of Surgeons National Surgical Quality Improvement Program Participant Use Data Files...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29124012/necrotizing-soft-tissue-infection-of-the-thigh-associated-with-retroperitoneal-abscess-in-a-patient-with-locally-advanced-ascending-colon-cancer-a-case-report
#5
Shotaro Harada, Takaharu Kato, Shinichiro Okada, Kensuke Nakatani, Risa Matsumoto, Kazuhiro Nishida, Hiroyasu Komuro, Ai Yokoyama, Chikara Takase, Toshiyuki Suganuma
Necrotizing soft tissue infection (NSTI) is a rare but rapidly progressing soft-tissue infection. Few reports of NSTI caused by colon cancer have been published. We present a rare case of NSTI of the thigh associated the retroperitoneal spread of ascending colon cancer. A 64-year-old man had noticed right hip pain since 3 months before admission, he felt pain in the right thigh which was reddening, and he had difficulty in walking. He was referred to Yokosuka general hospital Uwamachi. Anterolateral aspect of his right thigh was reddening and swelling...
2017: IDCases
https://www.readbyqxmd.com/read/28982834/how-biomarkers-reflect-the-prognosis-and-treatment-of-necrotising-soft-tissue-infections-and-the-effects-of-hyperbaric-oxygen-therapy-the-protocol-of-the-prospective-cohort-protreat-study-conducted-at-a-tertiary-hospital-in-copenhagen-denmark
#6
Peter Polzik, Pär I Johansson, Ole Hyldegaard
INTRODUCTION: Not enough is known regarding the prognosis and treatment of necrotising soft tissue infections (NSTIs). Mortality has been shown to be 25%-35%, with survivors coping with amputations and prolonged rehabilitation. This study will evaluate soluble urokinase-type plasminogen activator receptor (suPAR) as a possible prognostic marker of NSTI severity and mortality, as well as whether hyperbaric oxygen therapy (HBOT) can modulate markers of endothelial damage during NSTI. We hypothesise that in patients with NSTI, suPAR can provide prognostic risk assessment on hospital admission and that HBOT can reduce the endothelial damage that these patients are exposed to...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28892969/fistulating-richter-s-hernia-of-groin-with-necrotizing-soft-tissue-infection-a-lethal-combination
#7
Shibojit Talukder, Ashish Gupta, Basant Narayan Singh, Lileswar Kaman, P Abhinaya Reddy
Strangulation of groin hernia can result in significant morbidity and mortality. Spontaneous external fistulation following strangulation is rare and typically occurs with Richter's hernia. Spreading Necrotizing Soft Tissue Infection (NSTI) secondary to Enterocutaneous Fistula (ECF) is an ominous sign, further worsening its prognosis. Early diagnosis and prompt surgical treatment is crucial to improve outcome. Herewith the authors are presenting a case of neglected inguinal hernia. It was complicated with ECF formation and rapidly spreading NSTI of flank...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28863028/associations-of-plasma-nitrite-l-arginine-and-asymmetric-dimethylarginine-with-morbidity-and-mortality-in-patients-with-necrotizing-soft-tissue-infections
#8
Marco Bo Hansen, Lars Simon Rasmussen, Peter Garred, Katrine Pilely, Anna Mygind Wahl, Anders Perner, Martin Bruun Madsen, Elise Røge Hedegaard, Ulf Simonsen, Ole Hyldegaard
BACKGROUND: The nitric oxide system could play an important role in the pathophysiology related to necrotizing soft tissue infection (NSTI). Accordingly, we investigated the association between plasma nitrite level at admission and the presence of septic shock in patients with NSTI. We also evaluated the association between nitrite, asymmetric dimethylarginine (ADMA), L-arginine, L-arginine/ADMA-ratio and outcome. METHODS: We analyzed plasma from 141 NSTI patients taken upon hospital admission...
August 31, 2017: Shock
https://www.readbyqxmd.com/read/28814893/presentation-and-outcomes-of-necrotizing-soft-tissue-infections
#9
Kuan-Chin Jean Chen, Michelle Klingel, Shelley McLeod, Sean Mindra, Victor K Ng
BACKGROUND: Necrotizing soft tissue infections (NSTIs) are aggressive infections associated with significant morbidity, including amputation and organ failure, and high mortality. The rapid progression and significant risk of morbidity and mortality associated with NSTIs makes quick diagnosis and treatment critical. The objective of this study was to determine the presentation of patients diagnosed with NSTIs and their in-hospital outcomes. METHODS: This was a retrospective review of adult (>17 years) patients with a discharge diagnosis of necrotizing fasciitis at London Health Sciences Centre (annual census 125,000) over a 5-year period (April 2008-March 2013)...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28762168/the-role-of-computed-tomography-in-the-diagnosis-of-necrotizing-soft-tissue-infections
#10
Myriam Martinez, Thomas Peponis, Aglaia Hage, Daniel D Yeh, Haytham M A Kaafarani, Peter J Fagenholz, David R King, Marc A de Moya, George C Velmahos
BACKGROUND: The exact role of IV contrast-enhanced computed tomography (CT) in the diagnosis of necrotizing soft tissue infections (NSTIs) has not yet been established. We aimed to explore the role of CT in patients with clinical suspicion of NSTI and assess its sensitivity and specificity for NSTI. METHODS: The medical records of patients admitted between 2009 and 2016, who received IV contrast-enhanced CT to rule out NSTI, were reviewed. CT was considered positive in case of: (a) gas in soft tissues, (b) multiple fluid collections, (c) absence or heterogeneity of tissue enhancement by the IV contrast, and (d) significant inflammatory changes under the fascia...
January 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/28673381/biomarkers-of-necrotising-soft-tissue-infections-aspects-of-the-innate-immune-response
#11
Marco Bo Hansen
Necrotising soft tissue infection (NSTI) is a life-threatening and rapidly progressing bacterial infection involving one or more layers of the soft tissue compartments causing necrosis. The amputation and mortality rates remain high despite increased focus on the patients. Timely treatment, including surgical intervention, reduces the risk of severe disability and death. However, the lack of pathognomonic signs impedes early diagnosis and treatment. Moreover, the rarity of the disease makes it difficult to conduct large prospective studies, thus prospective research is almost non-existent in this group of patients...
July 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28641951/necrotizing-fasciitis-attended-in-the-emergency-department-in-a-tertiary-hospital-evaluation-of-the-lrinec-scale
#12
J R Ballesteros-Betancourt, R García-Tarriño, J Ríos-Guillermo, J M Rodriguez-Roiz, P Camacho, A Zumbado-Dijeres, A Domingo-Trepat, M Llusá-Pérez, A Combalia-Aleu, S García-Ramiro, A Soriano-Viladomiu
AIM: To describe mortality and complications of patients seen in the emergency room, diagnosed with necrotizing soft tissue infection (NSTI) and the correlation of such complications with the Laboratory Risk Indicator for Necrotizing fasciitis scale (LRINEC). METHODS: Retrospective observational study including patients with a diagnosis of NSTI in the emergency room of a tertiary hospital over 7 years. The results are shown as median, interquartile range and absolute range for quantitative variables...
July 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28628390/influence-of-screw-surface-treatment-on-retention-of-implant-supported-fixed-partial-dentures
#13
Marcos Boaventura de Moura, Renata Borges Rodrigues, Leandro Moreira Pinto, Cleudmar Amaral de Araújo, Veridiana Resende Novais, Paulo Cézar Simamoto Júnior
The aim of this study was to assess the effect of a diamond-like carbon (DLC) coating on the removal torque of prefabricated implant screws after cyclic loading. Four groups with two crowns supported by two implants (n = 5) were obtained according to splinted and nonsplinted prosthesis, using titanium or DLC screws (splinted crowns with titanium screw [STi], splinted crowns with DLC screw [SC], nonsplinted crowns and titanium screw [NSTi], and nonsplinted crowns and DLC screw [NSC]). The prosthetic screws were tightened at 32 Ncm and retightened, and the specimens were submitted to 106 mechanical cycles (4 Hz/98 N)...
August 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28538644/validation-of-a-clinical-trial-composite-endpoint-for-patients-with-necrotizing-soft-tissue-infections
#14
RANDOMIZED CONTROLLED TRIAL
Eileen M Bulger, Addison May, Wayne Dankner, Gregory Maislin, Bryce Robinson, Anat Shirvan
OBJECTIVE: Our objective was to develop and validate a composite endpoint for patients with necrotizing soft tissue infections that incorporates: local tissue injury, systemic organ dysfunction, and mortality. METHODS: The Necrotizing Infection Clinical Composite Endpoint (NICCE) was defined as follows:(i) alive at day 28, (ii) three or less debridements before day 14, (iii) no amputation beyond first debridement, (iv) modified sequential organ failure assessment score score (mSOFA) at day 14 ≤ 1...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28452064/mortality-of-necrotizing-fasciitis-relative-influence-of-individual-and-hospital-level-factors-a-nationwide-multilevel-study-france-2007-12
#15
E Audureau, C Hua, N de Prost, F Hemery, J W Decousser, R Bosc, R Lepeule, O Chosidow, E Sbidian
BACKGROUND: Necrotizing soft-tissue infections (NSTI) are rare, life-threatening conditions. OBJECTIVES: To assess whether admitting hospital characteristics were associated with NSTI mortality. METHODS: We studied the French nationwide hospital discharge database (retrospective national cohort). All patients admitted in the period 2007-12 with an International Classification of Diseases 10 code of necrotizing fasciitis were eligible. We extracted data on the patients (age, sex, intensive care unit admission, comorbidities) and hospitals (public vs...
April 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28421246/immunoglobulin-g-for-patients-with-necrotising-soft-tissue-infection-instinct-a-randomised-blinded-placebo-controlled-trial
#16
Martin B Madsen, Peter B Hjortrup, Marco B Hansen, Theis Lange, Anna Norrby-Teglund, Ole Hyldegaard, Anders Perner
PURPOSE: The aim of the INSTINCT trial was to assess the effect of intravenous polyspecific immunoglobulin G (IVIG) compared with placebo on self-reported physical function in intensive care unit (ICU) patients with necrotising soft tissue infection (NSTI). METHODS: We randomised 100 patients with NSTI 1:1 to masked infusion of 25 g of IVIG (Privigen, CSL Behring) or an equal volume of 0.9% saline once daily for the first 3 days of ICU admission. The primary outcome was the physical component summary (PCS) score of the 36-item short form health survey (SF-36) 6 months after randomisation; patients who had died were given the lowest possible score (zero)...
November 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28398176/septic-shock-due-to-nsti-caused-by-actinomyces-turicensis-the-role-of-clinical-pharmacology-case-report-and-review-of-the-literature
#17
Milo Gatti, Laura Elisa Gasparini, Chiara Maria Grimaldi, Daniela Abbati, Stefano Clemente, Paolo Riccardo Brioschi, Roberto Fumagalli, Francesco Scaglione
Critical septic patients affected by necrotizing soft tissue infections (NSTI) require an early, aggressive and multidisciplinary treatment. Pharmacokinetic alterations in antibiotic therapy are peculiar in these infections. Clinical pharmacology represents a first step in this setting. We report a case of septic shock due to NSTI in which clinical pharmacology is taken into account.
December 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28375805/management-and-novel-adjuncts-of-necrotizing-soft-tissue-infections
#18
REVIEW
Christine S Cocanour, Phillip Chang, Jared M Huston, Charles A Adams, Jose J Diaz, Charles B Wessel, Bonnie A Falcione, Graciela M Bauza, Raquel A Forsythe, Matthew R Rosengart
Necrotizing soft tissue infections (NSTI) have been recognized for millennia and continue to impose considerable burden on both patient and society in terms of morbidity, death, and the allocation of resources. With improvements in the delivery of critical care, outcomes have improved, although disease-specific therapies are lacking. The basic principles of early diagnosis, of prompt and broad antimicrobial therapy, and of aggressive debridement have remained unchanged. Clearly novel and new therapeutics are needed to combat this persistently lethal disease...
April 2017: Surgical Infections
https://www.readbyqxmd.com/read/28292567/images-of-suffering-depicted-in-diaries-of-family-caregivers-in-the-acute-stage-of-necrotising-soft-tissue-infection-a-content-analysis
#19
Ingrid Egerod, Annette E Andersson, Ann-Mari Fagerdahl, Vibeke E Knudsen
OBJECTIVES: Severe necrotising soft tissue infections (NSTI) are rare life threatening rapidly progressing bacterial infections requiring immediate diagnosis and treatment. The aim of the study was to explore the experience of family caregivers of patients with necrotising soft tissue infection during the acute stage of disease. METHODS: Our study had a qualitative descriptive binational design using qualitative content analysis to explore diaries written by close family members (n=15)...
August 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28266045/outcomes-in-necrotizing-soft-tissue-infections-treated-with-therapeutic-plasma-exchange
#20
Nabiha Huq Saifee, Heather L Evans, Amalia S Magaret, John R Hess, Meghan Delaney, Grant E O'Keefe, Tam N Pham, Hugh Foy, Eileen Bulger, Monica B Pagano
BACKGROUND: Treatment of necrotizing soft tissue infections (NSTIs) includes prompt surgical debridement and antibiotics, but despite standard care, the morbidity and mortality remain high. Since therapeutic plasma exchange (TPE) has been considered for treatment of severe sepsis, this study evaluates the efficacy of TPE for patients with NSTI. STUDY DESIGN AND METHODS: This is a retrospective study of patients with diagnosis of NSTI who received treatment with and without TPE over an 11-year period...
June 2017: Transfusion
keyword
keyword
108748
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"