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https://www.readbyqxmd.com/read/28931126/cutaneous-mycobacterium-gordonae-infection-in-an-elderly-diabetic-returned-traveller
#1
Ibrahim Al-Busaidi, Daniel Wong, Andrea K Boggild
Mycobacterium gordonae, a low pathogenicity organism, is rarely implicated in skin and soft tissue infections. We present a 77-year-old returned diabetic traveler from rural Sudan with cutaneous M. gordonae infection. Several months of ciprofloxacin, rifampin and ethambutol led to resolution of his plaque, without signs of recurrence at 6-month follow-up.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28930014/surveillance-of-extrapulmonary-nontuberculous-mycobacteria-infections-oregon-usa-2007-2012
#2
Emily Henkle, Katrina Hedberg, Sean D Schafer, Kevin L Winthrop
Limited data are available describing extrapulmonary nontuberculous mycobacteria (NTM) infections in the general population. We describe results from statewide population-based laboratory surveillance in Oregon, USA, during 2007-2012. We defined a case of extrapulmonary NTM infection as >1 isolate from skin/soft tissue, disseminated sites, lymph node, joint, or other sites. The annual incidence of extrapulmonary NTM infection (other than Mycobacterium gordonae) was stable, averaging 1.5 cases/100,000 population...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28929035/porcine-urinary-bladder-matrix-for-management-of-infected-radiation-mastectomy-wound
#3
Yana Puckett, Theophilus Pham, Shirley McReynolds, Catherine A Ronaghan
We present a case report on the successful healing of a Pseudomonas infection wound in a 52-year-old female with morbid obesity, noninsulin dependent diabetes mellitus and a history of tobacco use, who presented with Stage IIIA (T3, N2, Mo) infiltrating ductal carcinoma. The patient received neoadjuvant chemotherapy prior to her bilateral skin-sparing total mastectomies with right axillary sentinel lymphadenectomy. She also had staged reconstruction with temporary breast implants and plans for deep inferior epigastric perforator flaps...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28926380/osseointegrated-transtibial-implants-in-patients-with-peripheral-vascular-disease-a-multicenter-case-series-of-5-patients-with-1-year-follow-up
#4
Robin Atallah, Jiao Jiao Li, William Lu, Ruud Leijendekkers, Jan Paul Frölke, Munjed Al Muderis
BACKGROUND: Osseointegration is an alternative treatment for amputees who are unable to wear or have difficulty wearing a socket prosthesis. Although the majority of limb amputations are due to vascular disease, such amputations have been perceived as a contraindication to osseointegration surgery. We report the outcomes of osseointegrated reconstruction in a series of 5 patients with limb amputation due to peripheral vascular disease. METHODS: Five patients with transtibial amputation and a history of peripheral vascular disease who received an osseointegration implant from 2014 to 2015 were followed for 12 months...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28919283/clinical-manifestations-risk-factors-and-prognosis-of-patients-with-morganella-morganii-sepsis
#5
David Erlanger, Marc Victor Assous, Yonit Wiener-Well, Amos Moshe Yinnon, Eli Ben-Chetrit
BACKGROUND: There are few studies of Morganella bacteremia. We evaluated risk factors and outcome of patients with Morganella bacteremia. METHODS: Medical records of patients with Morganella bacteremia were reviewed (1997-2014). Control group patients with Escherichiacoli sepsis were matched by year of diagnosis and infection acquisition site. RESULTS: The study group included 136 adult patients. Mean age and gender of study and control groups were similar...
September 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28918832/streptococcus-anginosus-group-bacterial-infections
#6
Tasaduq Fazili, Scott Riddell, Deanna Kiska, Tim Endy, Luca Giurgea, Calden Sharngoe, Waleed Javaid
BACKGROUND: The Streptococcus anginosus group (SAG) causes a variety of infections in adults. To better understand the burden of SAG infections and their associated morbidity and mortality, we conducted a retrospective analysis of these infections in adults at a tertiary care center. METHODS: A retrospective review of all cultures positive for SAG in adults and a corresponding review of the patients' medical records were conducted at a tertiary care facility in central New York...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28918266/nanomedicine-for-safe-healing-of-bone-trauma-opportunities-and-challenges
#7
REVIEW
Shahed Behzadi, Gaurav A Luther, Mitchel B Harris, Omid C Farokhzad, Morteza Mahmoudi
Historically, high-energy extremity injuries resulting in significant soft-tissue trauma and bone loss were often deemed unsalvageable and treated with primary amputation. With improved soft-tissue coverage and nerve repair techniques, these injuries now present new challenges in limb-salvage surgery. High-energy extremity trauma is pre-disposed to delayed or unpredictable bony healing and high rates of infection, depending on the integrity of the soft-tissue envelope. Furthermore, orthopedic trauma surgeons are often faced with the challenge of stabilizing and repairing large bony defects while promoting an optimal environment to prevent infection and aid bony healing...
September 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28917520/short-term-complications-in-intra-and-extra-articular-anterior-cruciate-ligament-reconstruction-comparison-with-the-literature-on-isolated-intra-articular-reconstruction-a-multicenter-study-by-the-french-society-of-arthroscopy
#8
J C Panisset, R Pailhé, B Schlaterrer, L Sigwalt, B Sonnery-Cottet, C Lutz, S Lustig, C Batailler, S Bertiaux, F P Ehkirch, P Colombet, C Steltzlen, M L Louis, P D'ingrado, F Dalmay, P Imbert, D Saragaglia
INTRODUCTION: Lateral tenodesis (LT) is performed to limit the risk of iterative tear following anterior cruciate ligament (ACL) reconstruction in at-risk patients. By adding an extra procedure to isolated ACL graft, LT reconstruction increases operating time and may complicate postoperative course. The objective of the present study was to evaluate the rate of early complications. The study hypothesis was that associating ALL reconstruction to ACL reconstruction does not increase the complications rate found with isolated ACL reconstruction...
September 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28917436/comparison-of-the-loop-technique-with-incision-and-drainage-for-soft-tissue-abscesses-a-systematic-review-and-meta-analysis
#9
REVIEW
Michael Gottlieb, Gary D Peksa
INTRODUCTION: Skin and soft tissue infections are a common presentation to the emergency department. Traditional management of abscesses involves a linear incision through the center of the abscess with packing placed. The loop drainage technique (LDT) is an alternate approach that may reduce pain and scarring, as well as decrease the number of follow up visits needed. This systematic review and meta-analysis aimed to compare the efficacy of the LDT with conventional incision and drainage (CID) in the treatment of soft tissue abscesses...
September 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28917384/serious-infections-among-a-large-cohort-of-subjects-with-systemically-treated-psoriasis
#10
Allison S Dobry, Charles P Quesenberry, G Thomas Ray, Jamie L Geier, Maryam M Asgari
BACKGROUND: Biologic therapy is effective for treatment of moderate-to-severe psoriasis but may be associated with an increased risk for serious infection. OBJECTIVE: To estimate the serious infection rate among patients with psoriasis treated with biologic as compared with nonbiologic systemic agents within a community-based health care delivery setting. METHODS: We identified 5889 adult Kaiser Permanente Northern California health plan members with psoriasis who had ever been treated with systemic therapies and calculated the incidence rates and 95% confidence intervals (CIs) for serious infections over 29,717 person-years of follow-up...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28914343/image-guided-percutaneous-removal-of-ballistic-foreign-bodies-secondary-to-air-gun-injuries
#11
Jacob L Rothermund, Andrew J Rabe, Nicholas A Zumberge, James W Murakami, Patrick S Warren, Mark J Hogan
BACKGROUND: Ballistic injuries with retained foreign bodies from air guns is a relatively common problem, particularly in children and adolescents. If not removed in a timely fashion, the foreign bodies can result in complications, including pain and infection. Diagnostic methods to identify the presence of the foreign body run the entire gamut of radiology, particularly radiography, ultrasound (US) and computed tomography (CT). Removal of the foreign bodies can be performed by primary care, emergency, surgical, and radiologic clinicians, with or without imaging guidance...
September 15, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28914105/bone-and-subcutaneous-adipose-tissue-pharmacokinetics-of-vancomycin-in-total-knee-replacement-patients
#12
Mats Bue, Mikkel Tøttrup, Pelle Hanberg, Otto Langhoff, Hanne Birke-Sørensen, Theis M Thillemann, Torben L Andersson, Kjeld Søballe
Background and purpose - The incidence of orthopedic methicillin-resistant Staphylococcus aureus (MRSA) infections is increasing. Vancomycin may therefore play an increasingly important role in orthopedic perioperative antimicrobial prophylaxis. Studies investigating perioperative bone and soft tissue concentrations of vancomycin are sparse and challenged by a lack of appropriate methods. We assessed single-dose plasma, subcutaneous adipose tissue (SCT) and bone concentrations of vancomycin using microdialysis in male patients undergoing total knee replacement...
September 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28912980/sporotrichoid-like-spread-of-cutaneous-mycobacterium-chelonae-in-an-immunocompromised-patient
#13
Daria Marley Kemp, Anusha G Govind, Jun Kang, Caroline C Brugger, Young C Kauh
Mycobacterium chelonae is a rapidly growing mycobacterium found in water and soil that can cause local cutaneous infections in immunocompetent hosts but more frequently affects immunocompromised patients. Typically, patients will present with painful subcutaneous nodules of the joints or soft tissues from traumatic inoculation. However, exhibiting a sporotrichoid-like pattern of these nodules is uncommon. Herein, we report a case of sporotrichoid-like distribution of cutaneous Mycobacterium chelonae in a patient with systemic lupus erythematosus on significant immunosuppressive medications...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28904724/treatment-of-high-energy-pilon-fractures-using-the-ilizarov-treatment
#14
Walid Osman, Zeineb Alaya, Hamdi Kaziz, Lassad Hassini, Meriem Braiki, Nader Naouar, Mohamed Laaziz Ben Ayeche
The management of high-energy pilon fractures is still controversial. Open reduction and internal fixation are often associated with serious complications. Various methods have been used to treat these injuries, with variable results. The aim of this retrospective study was to analyze the clinical and radiographic outcome of the ILIZAROV technique in patients with high-energy pilon fractures. Thirty cases of distal tibia epiphysis fractures (pilon fractures) were managed from 1999 to 2012. The study group included 5 cases of open fractures...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904688/cellulitis-in-aged-persons-a-neglected-infection-in-the-literature
#15
Anis Mzabi, Wafa Marrakchi, Zeineb Alaya, Fatma Ben Fredj, Amel Rezgui, Elyès Bouajina, Chedia Laouani Kechrid
Cellulitis is a frequent soft tissue and skin infection. The lower limbs are affected in 70 to 80% of cases. Cellulitis in aged persons is not yet well described in literature. A retrospective descriptive study conducted in the Internal Medicine Department of Sahloul hospital in Sousse in Tunisia. It included patients whose age was up to 65 years old admitted into hospital for cellulitis of the legs, the arms or the face. One hundred fifty eight patients with a mean age of 73 years old (range: 65 to 94 years old) were included...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903801/s-aureus-infections-in-chicago-2006-2014-increase-in-ca-mssa-and-decrease-in-mrsa-incidence
#16
M Ellen Acree, Ethan Morgan, Michael Z David
OBJECTIVE To examine trends in Staphylococcus aureus infections in adults and children at a single academic center in 2006-2014. DESIGN Retrospective cohort study. SETTING Inpatient, outpatient, and emergency department settings in a private, tertiary referral center. PATIENTS Patients with an infection culture that grew S. aureus in January 1, 2006, through March 31, 2014. METHODS The first isolate per year for each patient was classified as community-associated (CA-), healthcare-associated (HA-), or HA-community-onset S...
October 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28900682/treatment-of-staphylococcus-aureus-infections
#17
Michael Z David, Robert S Daum
Staphylococcus aureus, although generally identified as a commensal, is also a common cause of human bacterial infections, including of the skin and other soft tissues, bones, bloodstream, and respiratory tract. The history of S. aureus treatment is marked by the development of resistance to each new class of antistaphylococcal antimicrobial drugs, including the penicillins, sulfonamides, tetracyclines, glycopeptides, and others, complicating therapy. S. aureus isolates identified in the 1960s were sometimes resistant to methicillin, a ß-lactam antimicrobial active initially against a majority S...
September 13, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28900424/the-impact-of-the-staphylococcus-aureus-virulome-on-infection-in-a-developing-country-a-cohort-study
#18
Marthe Lebughe, Patrick Phaku, Silke Niemann, Dieudonné Mumba, Georg Peters, Jean-Jacques Muyembe-Tamfum, Alexander Mellmann, Lena Strauß, Frieder Schaumburg
We performed a cohort study to analyze the virulome of Staphylococcus aureus from the Democratic Republic of the Congo using whole genome sequencing and to assess its impact on the course of S. aureus infections. Community-associated S. aureus from nasal colonization (n = 100) and infection (n = 86) were prospectively collected. Phenotypic susceptibility testing and WGS was done for each isolate. WGS data were used to screen for 79 different virulence factors and for genotyping purposes (spa typing, multilocus sequence typing)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28899559/emergency-general-surgery-and-trauma-outcomes-from-the-first-consultant-led-service-in-singapore
#19
Sachin Mathur, Woan Wui Lim, Tiong Thye Goo
INTRODUCTION: There is a significant burden on public health systems from emergency surgical and trauma (ESAT) patients. In Western countries, the response has been to separate acute and elective surgery with the creation of a new sub-specialty: acute care surgery. Dedicated acute units have shown improvements in efficiency and clinical outcomes for patients. The aim of this study was to assess the results of the first such unit in Singapore. MATERIALS AND METHODS: A retrospective analysis was performed of a 12-month period of acute admissions between May 2014 and April 2015, with comparison of 6-months before and after the creation of the ESAT service...
September 5, 2017: Injury
https://www.readbyqxmd.com/read/28895889/the-skin-bacterium-propionibacterium-acnes-employs-two-variants-of-hyaluronate-lyase-with-distinct-properties
#20
Seven Nazipi, Kristian Stødkilde-Jørgensen, Carsten Scavenius, Holger Brüggemann
Hyaluronic acid (HA) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. One of the most prevalent skin microorganisms, Propionibacterium acnes, possesses HA-degrading activity, possibly conferred by the enzyme hyaluronate lyase (HYL). In this study, we identified the HYL of P. acnes and investigated the genotypic and phenotypic characteristics. Investigations include the generation of a P. acneshyl knockout mutant and HYL activity assays to determine the substrate range and formed products...
September 12, 2017: Microorganisms
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