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High frequency spinal cord stimulation

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https://www.readbyqxmd.com/read/28321419/pvaxhsp65-vaccination-primes-for-high-il-10-production-and-decreases-experimental-encephalomyelitis-severity
#1
Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori
Experimental autoimmune encephalomyelitis (EAE) is a demyelinating pathology of the central nervous system (CNS) used as a model to study multiple sclerosis immunopathology. EAE has also been extensively employed to evaluate potentially therapeutic schemes. Considering the presence of an immune response directed to heat shock proteins (hsps) in autoimmune diseases and the immunoregulatory potential of these molecules, we evaluated the effect of a previous immunization with a genetic vaccine containing the mycobacterial hsp65 gene on EAE development...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28282844/transcranial-direct-current-stimulation-in%C3%A2-individuals-with-spinal-cord-injury-assessment-of-autonomic-nervous-system-activity
#2
Fabiana Tenório Gomes da Silva, Rodrigo Alberto Vieira Browne, Camila Bonin Pinto, Faddi Ghassan Saleh Velez, Eryvaldo Sócrates Tabosa do Egito, Jeferson Tafarel Pereira do Rêgo, Marília Rodrigues da Silva, Paulo Moreira Silva Dantas, Felipe Fregni
BACKGROUND: We hypothesized in this study that transcranial direct current stimulation (tDCS) of primary motor cortex could exert top-down modulation over subcortical systems associated with autonomic control and thus be useful to revert some of the dysfunctional changes found in the autonomic nervous system (ANS) of subjects with spinal cord injuries (SCI). OBJECTIVE: To explore the acute effect of tDCS on ANS indexed by Heart Rate Variability (HRV) in individuals with SCI and analyze whether this effect depends on the gender, degree, level and time of injury...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28266756/high-frequency-spinal-cord-stimulation-in-surgery-na%C3%A3-ve-patients-a-prospective-single-center-study
#3
Sebastian A Ahmadi, Jan Vesper, Stefan Schu, Philipp J Slotty
INTRODUCTION: A multitude of evidence supporting the beneficial effects of spinal cord stimulation (SCS) in patients suffering from chronic pain syndromes following spinal surgery has been published in the last decade. Evidence is scarce, however, for the use of high frequency SCS (HF-SCS) in the treatment of surgery naïve patients suffering from lower back pain (LBP). METHODS: From June 2014 to April 2015, we prospectively enrolled patients suffering from LBP alone or in conjunction with leg pain in a trial of HF-SCS...
March 7, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28168212/novel-synaptobrevin-1-mutation-causes-fatal-congenital-myasthenic-syndrome
#4
Xin-Ming Shen, Rosana H Scola, Paulo J Lorenzoni, Cláudia S K Kay, Lineu C Werneck, Joan Brengman, Duygu Selcen, Andrew G Engel
OBJECTIVE: To identify the molecular basis and elucidate the pathogenesis of a fatal congenital myasthenic syndrome. METHODS: We performed clinical electrophysiology studies, exome and Sanger sequencing, and analyzed functional consequences of the identified mutation. RESULTS: Clinical electrophysiology studies of the patient revealed several-fold potentiation of the evoked muscle action potential by high frequency nerve stimulation pointing to a presynaptic defect...
February 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28079781/transcutaneous-nerve-stimulation-for-pain-relief-during-office-hysteroscopy-a-randomized-controlled-trial
#5
Juan F Lisón, Juan J Amer-Cuenca, Silvia Piquer-Martí, Vicente Benavent-Caballer, Gemma Biviá-Roig, Alejandro Marín-Buck
OBJECTIVE: To evaluate the pain-relieving effect of transcutaneous electrical nerve stimulation (TENS) during office-based hysteroscopy without sedation. METHODS: We conducted a randomized, double-blind, placebo-controlled trial. Participants were randomly assigned to the active TENS, placebo TENS, or control group. The active TENS intervention consisted of a varying high-frequency (80-100 Hz), 400-microseconds, individually adjusted, high-intensity TENS application with two self-adhesive electrodes placed parallel to the spinal cord at the T10-L1 and S2-S4 levels...
February 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28072810/high-frequency-spinal-cord-stimulation-for-complex-regional-pain-syndrome-a-case-report
#6
Joseph T Crapanzano, Lisa M Harrison-Bernard, Mark R Jones, Alan D Kaye, Erich O Richter, Mordeci N Potash
Complex regional pain syndrome (CRPS) is a chronic, debilitating, neuropathic pain condition which is often misdiagnosed, difficult to manage, and lacks proven methods for remission. Most available methods provide some relief to a small percentage of patients. Recent FDA approval and superiority of the Nevro Senza 10-kHz high frequency (HF10) spinal cord stimulation (SCS) therapy over traditional low-frequency spinal cord stimulation for treatment of chronic back and leg pain may provide a new interventional therapeutic option for patients suffering from CRPS...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28025843/10-khz-high-frequency-spinal-cord-stimulation-for-chronic-axial-low-back-pain-in-patients-with-no-history-of-spinal-surgery-a-preliminary-prospective-open-label-and-proof-of-concept-study
#7
Adnan Al-Kaisy, Stefano Palmisani, Thomas E Smith, David Pang, Khai Lam, William Burgoyne, Russell Houghton, Emma Hudson, Jonathan Lucas
OBJECTIVE: To explore the effectiveness of 10 kHz high frequency spinal cord stimulation (HF10 therapy) treatment of chronic low back pain in patients who have not had spinal surgery. METHODS: Patients with chronic low back pain without prior spinal surgery were evaluated by a team of spine surgeons to rule out any spinal pathology amenable to surgical interventions and by a multidisciplinary pain team to confirm eligibility for the study. After a successful (>50% back pain reduction) trial of HF10 therapy, enrolled subjects underwent permanent system implantation and were followed-up one year post-implant...
January 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28025366/high-frequency-spinal-cord-stimulation-for-chronic-pain-pre-clinical-overview-and-systematic-review-of-controlled-trials
#8
REVIEW
Mark C Bicket, Roger Y Dunn, Shihab U Ahmed
OBJECTIVE: To assess the evidence base for high-frequency spinal cord stimulation (HFSCS). HFSCS has the potential to provide paresthesia-free pain relief for patients with chronic pain, in contrast to conventional spinal cord stimulation, which produces distracting and potentially unpleasant paresthesias. DESIGN: A systematic review following standard methodological guidelines (Prospero #CRD42015029215). METHODS: We searched PubMed to March 14, 2016 without language restriction and hand-checked reference lists...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28007585/the-prrt2-knockout-mouse-recapitulates-the-neurological-diseases-associated-with-prrt2-mutations
#9
Caterina Michetti, Enrico Castroflorio, Ivan Marchionni, Nicola Forte, Bruno Sterlini, Francesca Binda, Floriana Fruscione, Pietro Baldelli, Flavia Valtorta, Federico Zara, Anna Corradi, Fabio Benfenati
Heterozygous and rare homozygous mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders including epilepsy, kinesigenic dyskinesia episodic ataxia and migraine. Most of the mutations lead to impaired PRRT2 expression and/or function. Recently, an important role for PRTT2 in the neurotransmitter release machinery, brain development and synapse formation has been uncovered. In this work, we have characterized the phenotype of a mouse in which the PRRT2 gene has been constitutively inactivated (PRRT2 KO)...
March 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28004950/stimulation-of-5-ht2a-receptors-recovers-sensory-responsiveness-in-acute-spinal-neonatal-rats
#10
Hillary E Swann, Sierra D Kauer, Jacob T Allmond, Michele R Brumley
Quipazine is a 5-HT2A-receptor agonist that has been used to induce motor activity and promote recovery of function after spinal cord injury in neonatal and adult rodents. Sensory stimulation also activates sensory and motor circuits and promotes recovery after spinal cord injury. In rats, tail pinching is an effective and robust method of sacrocaudal sensory afferent stimulation that induces motor activity, including alternating stepping. In this study, responsiveness to a tail pinch following treatment with quipazine (or saline vehicle control) was examined in spinal cord transected (at midthoracic level) and intact neonatal rats...
February 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28004906/transcranial-and-spinal-cord-magnetic-stimulation-in-treatment-of-spasticity-a-literature-review-and-meta-analysis
#11
Julia Korzhova, Dmitry Sinitsyn, Alexander Chervyakov, Alexandra Poydasheva, Maria Zakharova, Natalia Suponeva, Lyudmila Chernikova, Michael Piradov
INTRODUCTION: Spasticity is associated with various diseases of the nervous system. Current treatments such as drug therapy, botulinum toxin injections, kinesitherapy, and physiotherapy are not sufficiently effective in a large number of patients. Transcranial magnetic stimulation (TMS) can be considered as an alternative method of treatment. The purpose of this article is to conduct a systematic review and meta-analysis of all available publications assessing the efficacy of repetitive TMS in treatment of spasticity...
December 22, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27891705/spinal-cord-stimulation-in-experimental-chronic-painful-diabetic-polyneuropathy-delayed-effect-of-high-frequency-stimulation
#12
M van Beek, M van Kleef, B Linderoth, S M J van Kuijk, W M Honig, E A Joosten
BACKGROUND: Spinal cord stimulation (SCS) has been shown to provide pain relief in painful diabetic polyneuropathy (PDPN). As the vasculature system plays a great role in the pathophysiology of PDPN, a potential beneficial side-effect of SCS is peripheral vasodilation, with high frequency (HF) SCS in particular. We hypothesize that HF-SCS (500 Hz), compared with conventional (CON) or low frequency (LF)-SCS will result in increased alleviation of mechanical hypersensitivity in chronic experimental PDPN...
November 28, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27875377/spinal-cord-stimulation-for-refractory-angina-pectoris-a-systematic-review-and-meta-analysis
#13
Xiaoxiao Pan, Hongguang Bao, Yanna Si, Chenjie Xu, Hao Chen, Xianzhong Gao, Xinyi Xie, Yajie Xu, Fan Sun, Lingqing Zeng
OBJECTIVES: Parasthesia free stimulation, such as high frequency and burst have been demonstrated as effective therapies for neuropathic pain. The aim of this meta-analysis was to evaluate the efficacy and safety of conventional spinal cord stimulation (SCS) in the treatment of refractory angina pectoris (RAP). METHODS: Relevant randomized controlled trial (RCT) studies that investigated SCS for patients with RAP were comprehensively searched in Medline, Pubmed, Embase, and Cochrane Library...
November 21, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27856287/the-inhibition-of-spinal-synaptic-plasticity-mediated-by-activation-of-amp-activated-protein-kinase-signaling-alleviates-the-acute-pain-induced-by-oxaliplatin
#14
Yun-Zhi Ling, Zhen-Yu Li, Han-Dong Ou-Yang, Chao Ma, Shao-Ling Wu, Jia-You Wei, Huan-Huan Ding, Xiao-Long Zhang, Meng Liu, Cui-Cui Liu, Zhen-Zhen Huang, Wen-Jun Xin
Our recent findings demonstrated that oxaliplatin entering CNS may directly induce spinal central sensitization, and contribute to the rapid development of CNS-related side effects including acute pain during chemotherapy. However, the mechanism is largely unclear. In the current study, we found that the amplitude of C-fiber-evoked field potentials was significantly increased and the expression of phosphorylated mammalian AMP-activated protein kinase α (AMPKα) was markedly decreased following high frequency stimulation (HFS) or single intraperitoneal injection of oxaliplatin (4mg/kg)...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27832210/gm-csf-producing-th-cells-in-rats-sensitive-and-resistant-to-experimental-autoimmune-encephalomyelitis
#15
Zorica Stojić-Vukanić, Ivan Pilipović, Ivana Vujnović, Mirjana Nacka-Aleksić, Raisa Petrović, Nevena Arsenović-Ranin, Mirjana Dimitrijević, Gordana Leposavić
Given that granulocyte macrophage colony-stimulating factor (GM-CSF) is identified as the key factor to endow auto-reactive Th cells with the potential to induce neuroinflammation in experimental autoimmune encephalomyelitis (EAE) models, the frequency and phenotype of GM-CSF-producing (GM-CSF+) Th cells in draining lymph nodes (dLNs) and spinal cord (SC) of Albino Oxford (AO) and Dark Agouti (DA) rats immunized for EAE were examined. The generation of neuroantigen-specific GM-CSF+ Th lymphocytes was impaired in dLNs of AO rats (relatively resistant to EAE induction) compared with their DA counterparts (susceptible to EAE) reflecting impaired CD4+ lymphocyte proliferation and less supportive of GM-CSF+ Th cell differentiation dLN cytokine microenvironment...
2016: PloS One
https://www.readbyqxmd.com/read/27770599/high-frequency-spinal-cord-stimulation-in-a-patient-with-an-implanted-cardiac-device
#16
Narayan R Kissoon, Bryan C Hoelzer, David P Martin, Tim J Lamer
BACKGROUND: New advances in spinal cord stimulation have led to improved treatment of patients suffering from chronic pain. While the overall safety of newer stimulation devices has been established, no published reports exist regarding safety considerations when these devices are implanted in patients with a preexisting cardiac device. CASE REPORT: An 83-year-old man with a history of out-of-hospital cardiac arrest secondary to an episode of ventricular fibrillation underwent automated implantable cardiac defibrillator placement...
October 22, 2016: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/27721747/paired-associative-stimulation-with-high-frequency-peripheral-component-leads-to-enhancement-of-corticospinal-transmission-at-wide-range-of-interstimulus-intervals
#17
Anastasia Shulga, Aleksandra Zubareva, Pantelis Lioumis, Jyrki P Mäkelä
Background: In spinal paired associative stimulation (PAS), orthodromic and antidromic volleys elicited by transcranial magnetic stimulation (TMS) and peripheral nerve stimulation (PNS) coincide at corticomotoneuronal synapses at the spinal cord. The interstimulus interval (ISI) between TMS and PNS determines whether PAS leads to motor-evoked potential (MEP) potentiation or depression. PAS applied as a long-term treatment for neurological patients might alter conduction of neural fibers over time. Moreover, measurements of motoneuron conductance for determination of ISIs may be challenging in these patients...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27676804/management-of-neuropathic-central-pain-by-non-invasive-brain-stimulation-and-mirror-therapy
#18
Yann Le Déan, Benjamin Brissebrat, Evelyne Castel-Lacanal, Xavier De Boissezon, Philippe Marque
OBJECTIVE: Central neuropathic pain is common among neurological patients. Drug therapy has high pharmacoresistance and some GABAergic agents can be detrimental to the recovery process. Alternative therapies include neuromodulation techniques, such as repetitive transcranial magnetic stimulation (rTMS) and motor imagery techniques with mirror therapy. The objective of this study was to evaluate their effectiveness in clinical practice on central neuropathic pain. MATERIAL/PATIENTS AND METHODS: Thirty-two patients followed in the Physical Medicine and Rehabilitation department of Rangueil University Hospital were included...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27584814/comparison-of-10-khz-high-frequency-and-traditional-low-frequency-spinal-cord-stimulation-for-the-treatment-of-chronic-back-and-leg-pain-24-month-results-from-a-multicenter-randomized-controlled-pivotal-trial
#19
Leonardo Kapural, Cong Yu, Matthew W Doust, Bradford E Gliner, Ricardo Vallejo, B Todd Sitzman, Kasra Amirdelfan, Donna M Morgan, Thomas L Yearwood, Richard Bundschu, Thomas Yang, Ramsin Benyamin, Abram H Burgher
BACKGROUND: Pain relief with spinal cord stimulation (SCS) has focused historically on paresthesias overlapping chronically painful areas. A higher level evidence supports the use of SCS in treating leg pain than supports back pain, as it is difficult to achieve adequate paresthesia coverage, and then pain relief, in the low back region. In comparison, 10-kHz high-frequency (HF10 therapy) SCS therapy does not rely on intraoperative paresthesia mapping and remains paresthesia-free during therapy...
November 2016: Neurosurgery
https://www.readbyqxmd.com/read/27512251/effect-of-high-frequency-repetitive-transcranial-magnetic-stimulation-on-motor-cortical-excitability-and-sensory-nerve-conduction-velocity-in-subacute-stage-incomplete-spinal-cord-injury-patients
#20
Hyun Gyu Cha, Sang-Goo Ji, Myoung-Kwon Kim
[Purpose] The aim of the present study was to determine whether repetitive transcranial magnetic stimulation can improve sensory recovery of the lower extremities in subacute-stage spinal cord injury patients. [Subjects and Methods] This study was conducted on 20 subjects with diagnosed paraplegia due to spinal cord injury. These 20 subjects were allocated to an experimental group of 10 subjects that underwent active repetitive transcranial magnetic stimulation or to a control group of 10 subjects that underwent sham repetitive transcranial magnetic stimulation...
July 2016: Journal of Physical Therapy Science
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