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High frequency stimulation

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https://www.readbyqxmd.com/read/29454034/add-on-high-frequency-deep-transcranial-magnetic-stimulation-dtms-to-bilateral-prefrontal-cortex-in-depressive-episodes-of-patients-with-major-depressive-disorder-bipolar-disorder-i-and-major-depressive-with-alcohol-use-disorders
#1
Chiara Rapinesi, Georgios D Kotzalidis, Stefano Ferracuti, Nicoletta Girardi, Abraham Zangen, Gabriele Sani, Ruggero N Raccah, Paolo Girardi, Maurizio Pompili, Antonio Del Casale
BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is critically involved in mood and alcohol use disorders. OBJECTIVE: We aimed to investigate the safety of intervention with add-on bilateral prefrontal high-frequency deep transcranial magnetic stimulation (dTMS) and between-group differences in treatment response in patients with different types of depressive episodes, including major depressive episodes in the course of major depressive disorder (MDD), bipolar disorder, type I (BD-I), and MDD with alcohol use disorder (MDAUD)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29453932/neurotrophin-3-restores-synaptic-plasticity-in-the-striatum-of-a-mouse-model-of-huntington-s-disease
#2
Victor G Gómez-Pineda, Francisco M Torres-Cruz, César I Vivar-Cortés, Elizabeth Hernández-Echeagaray
AIMS: Neurotrophin-3 (NT-3) is expressed in the mouse striatum; however, it is not clear the NT-3 role in striatal physiology. The expression levels of mRNAs and immune localization of the NT-3 protein and its receptor TrkC are altered in the striatum following damage induced by an in vivo treatment with 3-nitropropionic acid (3-NP), a mitochondrial toxin used to mimic the histopathological hallmarks of Huntington's disease (HD). The aim of this study was to evaluate the role of NT-3 on corticostriatal synaptic transmission and its plasticity in both the control and damaged striatum...
February 17, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29450404/reengineering-deep-brain-stimulation-for-movement-disorders-emerging-technologies
#3
Aysegul Gunduz, Kelly D Foote, Michael S Okun
Deep brain stimulation (DBS) is a neurosurgical technique, which consists of continuous delivery of an electrical pulse through chronically implanted electrodes connected to a neurostimulator, programmable in amplitude, pulse width, frequency, and stimulation channel. DBS is a promising treatment option for addressing severe and drug-resistant movement disorders. The success of DBS therapy is a combination of surgical implantation techniques, device technology, and clinical programming strategies. Changes in device settings require highly trained and experienced clinicians to achieve maximal therapeutic benefit for each targeted symptom, and optimization of stimulation parameters can take many visits...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29449814/multisite-delayed-feedback-for-electrical-brain-stimulation
#4
Oleksandr V Popovych, Peter A Tass
Demand-controlled deep brain stimulation (DBS) appears to be a promising approach for the treatment of Parkinson's disease (PD) as revealed by computational, pre-clinical and clinical studies. Stimulation delivery is adapted to brain activity, for example, to the amount of neuronal activity considered to be abnormal. Such a closed-loop stimulation setup might help to reduce the amount of stimulation current, thereby maintaining therapeutic efficacy. In the context of the development of stimulation techniques that aim to restore desynchronized neuronal activity on a long-term basis, specific closed-loop stimulation protocols were designed computationally...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29444523/a-novel-animal-model-of-parkinson-s-disease-using-optogenetics-representation-of-various-disease-stages-by-modulating-the-illumination-parameter
#5
Eun Jung Lee, Hyung Ho Yoon, Eun Suk Park, Joongkee Min, Sang Ryong Jeon
BACKGROUND: The classic animal model of Parkinson's disease (PD) using neurotoxin can only simulate fixed stages of the disease by causing irreversible damage to the nigrostriatal system. OBJECTIVES: To develop an optogenetic PD model that can modulate the severity of disease by optical stimulation by introducing the halorhodopsin (NpHR) gene into the substantia nigra compacta. METHODS: Fifteen rats received injections of engineered AAV with NpHR-YFP gene into the substantia nigra...
February 14, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29443047/application-of-chronic-stimulation-to-study-contractile-activity-induced-rat-skeletal-muscle-phenotypic-adaptations
#6
Yuho Kim, Jonathan M Memme, David A Hood
Skeletal muscle is a highly adaptable tissue, as its biochemical and physiological properties are greatly altered in response to chronic exercise. To investigate the underlying mechanisms that bring about various muscle adaptations, a number of exercise protocols such as treadmill, wheel running, and swimming exercise have been used in the animal studies. However, these exercise models require a long period of time to achieve muscle adaptations, which may be also regulated by humoral or neurological factors, thus limiting their applications in studying the muscle-specific contraction-induced adaptations...
January 25, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29439359/effects-of-combining-high-and-low-frequency-repetitive-transcranial-magnetic-stimulation-on-upper-limb-hemiparesis-in-the-early-phase-of-stroke
#7
Hua Long, Hongbin Wang, Chenguang Zhao, Qiang Duan, Feng Feng, Nan Hui, Li Mao, Huiling Liu, Xiang Mou, Hua Yuan
BACKGROUND: Both high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) and low-frequency rTMS (LF-rTMS) are reported to benefit upper limb motor function rehabilitation in patients with stroke. However, the efficacy of combining LF- and HF-rTMS (LF-HF rTMS) has not been adequately explored, especially in the early phase of stroke. OBJECTIVE: To compare the effects of LF- and LF-HF rTMS on the upper limb motor function in the early phase post stroke...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29431275/burst-spinal-cord-stimulation-review-of-preclinical-studies-and-comments-on-clinical-outcomes
#8
REVIEW
Krishnan Chakravarthy, Alexander R Kent, Adil Raza, Fang Xing, Thomas M Kinfe
BACKGROUND: Burst spinal cord stimulation (SCS) technology uses a novel waveform that consists of closely packed high-frequency electrical impulses followed by a quiescent period. Within the growing field of neuromodulation, burst stimulation is unique in that it mimics the natural burst firing of the nervous system, in particular the thalamo-cingulate rhythmicity, resulting in modulation of the affective and attentional components of pain processing (e.g., medial thalamic pathways). STUDY DESIGN: A review of preclinical and clinical studies regarding burst SCS for various chronic pain states...
February 12, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29430661/glucose-and-lactate-as-metabolic-constraints-on-presynaptic-transmission-at-an-excitatory-synapse
#9
Sarah J Lucas, Christophe B Michel, Vincenzo Marra, Joshua L Smalley, Matthias H Hennig, Bruce P Graham, Ian D Forsythe
The synapse has high energy demands, which increase during intense activity. Presynaptic ATP production depends on substrate availability and usage will increase during activity, which in turn could influence transmitter release and information transmission. We investigated transmitter release at the mouse calyx of Held synapse using glucose or lactate (10, 1 or 0 mm) as the extracellular substrates while inducing metabolic stress. High frequency stimulation (HFS) and recovery paradigms evoked trains of EPSCs monitored under voltage-clamp...
February 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29429820/direct-bone-conduction-stimulation-ipsilateral-effect-of-different-transducer-attachments-in-active-transcutaneous-devices
#10
Cristina Rigato, Sabine Reinfeldt, Bo Håkansson, Karl-Johan Fredén Jansson, Erik Renvall, Måns Eeg-Olofsson
Active transcutaneous bone conduction devices, where the transducer is implanted, are used for rehabilitation of hearing impaired patients by directly stimulating the skull bone. The transducer and the way it is attached to the bone play a central role in the design of such devices. The actual effect of varying the contact to bone has not been addressed yet. The aim of this study is therefore to compare how different attachment methods of the transducer to the bone for direct stimulation affect the ear canal sound pressure and vibration transmission to the ipsilateral cochlea...
January 31, 2018: Hearing Research
https://www.readbyqxmd.com/read/29429705/synthesis-of-novel-sonocatalyst-er3-yalo3-nb2o5-and-its-application-for-sonocatalytic-degradation-of-methamphetamine-hydrochloride
#11
Chunsheng Wei, Kuiyu Yi, Guangsheng Sun, Jun Wang
The composited sonocatalyst Er3+:YAlO3/Nb2O5 was prepared by ultrasonic dispersion and high temperature calcinations method. The microstructure of Er3+:YAlO3 was prepared via sol-gel method and Nb2O5 was prepared by hydrothermal method. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDX), ultraviolet-visible (UV-vis) spectra and photoluminescence (PL) spectra, respectively. The sonocatalytic decomposition activity of composite sonocatalyst Er3+:YAlO3/Nb2O5 was investigated by using ultrasound as sound source and methamphetamine hydrochloride as the target degradation product...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29427848/targeting-alpha-band-oscillations-in-a-cortical-model-with-amplitude-modulated-high-frequency-transcranial-electric-stimulation
#12
Ehsan Negahbani, Florian H Kasten, Christoph S Herrmann, Flavio Frohlich
Non-invasive brain stimulation to target specific network activity patterns, e.g. transcranial alternating current stimulation (tACS), has become an essential tool to understand the causal role of neuronal oscillations in cognition and behavior. However, conventional sinusoidal tACS limits the ability to record neuronal activity during stimulation and lacks spatial focality. One particularly promising new tACS stimulation paradigm uses amplitude-modulated (AM) high-frequency waveforms (AM-tACS) with a slow signal envelope that may overcome the limitations...
February 7, 2018: NeuroImage
https://www.readbyqxmd.com/read/29423665/a-meta-analysis-of-the-effectiveness-of-different-cortical-targets-used-in-repetitive-transcranial-magnetic-stimulation-rtms-for-the-treatment-of-obsessive-compulsive-disorder-ocd
#13
REVIEW
Simone Rehn, Guy D Eslick, Vlasios Brakoulias
Randomised and sham-controlled trials (RCTs) of repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive-compulsive disorder (OCD) have yielded conflicting results, which may be due to the variability in rTMS parameters used. We performed an updated systematic review and meta-analysis on the effectiveness of rTMS for the treatment of OCD and aimed to determine whether certain rTMS parameters, such as cortical target, may be associated with higher treatment effectiveness. After conducting a systematic literature review for RCTs on rTMS for OCD through to 1 December 2016 using MEDLINE, PubMed, Web of Science, PsycINFO, Google, and Google Scholar, we performed a random-effects meta-analysis with the outcome measure as pre-post changes in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores...
February 9, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29421187/activation-of-the-subthalamic-nucleus-suppressed-by-high-frequency-stimulation-a-c-fos-immunohistochemical-study
#14
Safa Shehab, Crystal D'souza, Milos Ljubisavljevic, Peter Redgrave
Deep Brain Stimulation applied at high frequency (HFS) to the subthalamic nucleus (STN) is used to ameliorate the symptoms of Parkinson's disease. The mechanism by which this is achieved remains controversial. In particular, it is uncertain whether HFS has a suppressive or excitatory action locally within the STN. Brief exposure of rats to ether anaesthesia evokes pathological burst firing and associated expression of the immediate early gene c-Fos in STN neurons. We used this ether model of STN activation to test the effect of a range of HFS parameters on c-Fos expression evoked by the anesthetic...
February 5, 2018: Brain Research
https://www.readbyqxmd.com/read/29414594/changes-in-sleep-patterns-after-vagus-nerve-stimulation-deep-brain-stimulation-or-epilepsy-surgery-systematic-review-of-the-literature
#15
REVIEW
Óscar Romero-Osorio, Sebastián Gil-Tamayo, Daniel Nariño, Diego Rosselli
PURPOSE: Perform a systematic review of the literature on the effects of vagus nerve stimulation (VNS), deep brain stimulation (DBS) and epilepsy surgery in subjective and objective sleep parameters. METHODS: We performed a literature search in the main medical databases: Medline, Embase, Cochrane, DARE and LILACS, looking for studies that evaluated the effects of VNS, DBS or epilepsy surgery on sleep parameters. In all, 36 studies, coming from 11 countries, including reviews, cohort studies, case series and case reports were included...
January 31, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29409801/the-minimum-infusion-rate-of-alfaxalone-during-its-co-administration-with-lidocaine-at-three-different-doses-by-constant-rate-infusion-in-goats
#16
Brighton T Dzikiti, Patience S Ndawana, Loveness N Dzikiti, Frik G Stegmann
OBJECTIVE: To determine the minimum infusion rate (MIR) of alfaxalone required to prevent purposeful movement in response to standardized stimulation while co-administered with lidocaine at three different doses by constant infusion rate infusion (CRI) in goats. STUDY DESIGN: Prospective, blinded, randomized crossover, experimental. ANIMALS: A total of eight healthy goats: four does and four wethers. METHODS: Anaesthetic induction was with lidocaine at 1 mg kg-1 [low dose of lidocaine (L-Lid)], 2 mg kg-1 [moderate dose (M-Lid)] or 4 mg kg-1 [high dose (H-Lid)] and alfaxalone at 2 mg kg-1...
November 29, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29408880/daily-visual-stimulation-in-the-critical-period-enhances-multiple-aspects-of-vision-through-bdnf-mediated-pathways-in-the-mouse-retina
#17
Amanda M Mui, Victoria Yang, Moe H Aung, Jieming Fu, Adewumi N Adekunle, Brian C Prall, Curran S Sidhu, Han Na Park, Jeffrey H Boatright, P Michael Iuvone, Machelle T Pardue
Visual experience during the critical period modulates visual development such that deprivation causes visual impairments while stimulation induces enhancements. This study aimed to determine whether visual stimulation in the form of daily optomotor response (OMR) testing during the mouse critical period (1) improves aspects of visual function, (2) involves retinal mechanisms and (3) is mediated by brain derived neurotrophic factor (BDNF) and dopamine (DA) signaling pathways. We tested spatial frequency thresholds in C57BL/6J mice daily from postnatal days 16 to 23 (P16 to P23) using OMR testing...
2018: PloS One
https://www.readbyqxmd.com/read/29405548/efficacy-of-alternating-conventional-stimulation-and-high-frequency-stimulation-in-improving-spinal-cord-stimulation-outcomes-a-pilot-study
#18
Vignessh Kumar, Julia Prusik, Yufan Lin, Roy Hwang, Paul Feustel, Julie G Pilitsis
INTRODUCTION: Spinal cord stimulation (SCS) is an established, effective method of treating chronic pain. High frequency stimulation (HFS) is an alternative SCS waveform that has been shown to alleviate pain but also necessitates more frequent recharging. The purpose of this pilot study is to evaluate efficacy of alternating conventional stimulation and HFS (termed "shuffle" stimulation) in improving SCS outcomes. METHODS: Shuffle stimulation was designed to deliver conventional stimulation in upright positions with relative HFS in lying positions, automated through accelerometer technology...
February 5, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29402879/effects-of-high-frequency-repetitive-transcranial-magnetic-stimulation-combined-with-task-oriented-mirror-therapy-training-on-hand-rehabilitation-of-acute-stroke-patients
#19
Jinhong Kim, Jongeun Yim
BACKGROUND Impairments of hand function make it difficult to perform daily life activities and to return to work. The aim of this study was to investigate the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) combined with task-oriented mirror therapy (TOMT) on hand rehabilitation in acute stroke patients. MATERIAL AND METHODS Twenty subacute stroke patients in the initial stages (<3 months) participated in the study. Subjects were allocated to 2 groups: the experimental group received HF-rTMS + TOMT and the control group received HF-rTMS...
February 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29402815/introducing-a-virtual-lesion-model-of-dysphagia-resulting-from-pharyngeal-sensory-impairment
#20
Paul Muhle, Inga Claus, Thomas Marian, Jens B Schröder, Andreas Wollbrink, Christo Pantev, Tobias Warnecke, Rainer Dziewas, Sonja Suntrup-Krueger
BACKGROUND/AIMS: Performing neurophysiological and functional imaging studies in severely affected patients to investigate novel neurostimulation techniques for the treatment of neurogenic dysphagia is difficult. Therefore, basic research needs to be conducted in healthy subjects. Swallowing is a motor function highly dependent on sensory afferent input. Here we propose a virtual peripheral sensory lesion model to mimic pharyngeal sensory impairment, which is known as a major contributor to dysphagia in neurological disease...
January 25, 2018: Neuro-Signals
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