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Particulate matter and diabet

Hui-Chen Cheng, Ren-Hao Pan, Huan-Jui Yeh, K Robert Lai, May-Yung Yen, Chien-Lung Chan, An-Guor Wang
PURPOSE: To investigate whether daily changes in ambient air pollution were associated with an increased risk of central retinal artery occlusion (CRAO). DESIGN: Retrospective population-based cohort study. PARTICIPANTS: We identified patients newly diagnosed with CRAO between 2001 and 2013 in a representative database of 1 000 000 patients that were randomly selected from all registered beneficiaries of the National Health Insurance program in Taiwan...
October 13, 2016: Ophthalmology
Mei-Chun Lu, Panchalli Wang, Tsun-Jen Cheng, Chun-Pai Yang, Yuan-Horng Yan
BACKGROUND: To investigate the effects of fine particulate matter (PM2.5) on the indicators of glucose homeostasis during pregnancy. METHODS: A total of 3589 non-diabetic pregnant women who underwent a 3-h 100-g oral glucose tolerance test (OGTT) were enrolled from a tertiary teaching hospital in Chiayi City, Taiwan between 2006 and 2014. Fasting, 1-h, 2-h, and 3-h glucose levels after an OGTT were used as indicators of glucose homeostasis. PM2.5 and other air pollution data were obtained from one fixed-site monitoring station (Chiayi City station) operated by Taiwan Environmental Protection Administration (EPA)...
October 13, 2016: Environmental Research
Małgorzata Kowalska, Krzysztof Kocot
Results of epidemiological studies suggest a significant impact of ambient particulate matter air pollution (PM10 and PM2,5) on the health of the population. Increased level of these pollutants is connected with increased rate of daily mortality and hospitalizations due to cardiovascular diseases. Among analyzed health effects, heart arrhythmias and stroke are mentioned most frequently. The aim of the study was to present the current knowledge of potential influence of the exposure to fine particulate matter on the presence of arrhythmias and strokes...
September 28, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
Mutlay Sayan, Brooke T Mossman
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer's disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres...
2016: Particle and Fibre Toxicology
Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger, Annette Peters
Insulin resistance (IR) is present long before the onset of type 2 diabetes and results not only from inherited and lifestyle factors but likely also from environmental conditions. We investigated the association between modelled long-term exposure to air pollution at residence and biomarkers related to IR, subclinical inflammation and adipokines.Data was based on 2,944 participants of the KORA (Cooperative Health Research in the Region Augsburg) F4 study conducted in southern Germany (2006-2008). We analysed associations between individual air pollution concentration estimated by land use regression and HOMA-IR, glucose, insulin, HbA1c, leptin, and hs-CRP from fasting samples using multivariable linear regression models...
September 7, 2016: Diabetes
Asher Ornoy, Liza Weinstein-Fudim, Zivanit Ergaz
Autism spectrum disorder (ASD) affecting about 1% of all children is associated, in addition to complex genetic factors, with a variety of prenatal, perinatal, and postnatal etiologies. In addition, ASD is often an important clinical presentation of some well-known genetic syndromes in human. We discuss these syndromes as well as the role of the more important prenatal factors affecting the fetus throughout pregnancy which may also be associated with ASD. Among the genetic disorders we find Fragile X, Rett syndrome, tuberous sclerosis, Timothy syndrome, Phelan-McDermid syndrome, Hamartoma tumor syndrome, Prader-Willi and Angelman syndromes, and a few others...
2016: Frontiers in Neuroscience
J Marvin Herndon
BACKGROUND: U.S. military perception of nuclear warfare led to countless unethical nuclear experiments performed on unsuspecting individuals without their informed consent. As evidenced here, subsequent perception of weather warfare has led to exposing millions of unsuspecting individuals to toxic coal fly ash with no public disclosure, no informed consent, and no health warnings. METHODS: Three methods were used: (1) comparison of eight elements analyzed in rainwater samples, thought to have leached from aerosolized coal fly ash, with corresponding coal fly ash laboratory leachate; (2) comparison of 14 elements analyzed in air filter dust with corresponding elements in coal fly ash; and (3) comparison of 23 elements analyzed in fibrous mesh found after snow melted with corresponding elements in coal fly ash...
2016: Frontiers in Public Health
Jungwoo Sohn, Seng Chan You, Jaelim Cho, Yoon Jung Choi, Boyoung Joung, Changsoo Kim
Many epidemiological studies have reported associations between ambient particulate matter (PM) and cardiovascular diseases. However, the effects associated with PM that promote cardiovascular events among susceptible populations who may respond differently than the general population to the same ambient air pollutants remain unclear. We conducted a time-series study with generalized additive models to assess the association between ambient PM10 and emergency department (ED) visits for ischemic heart disease (IHD) in Seoul, Republic of Korea from 2005 to 2009...
October 2016: Environmental Science and Pollution Research International
Pauline Brendler Goettems-Fiorin, Bethânia Salamoni Grochanke, Fernanda Giesel Baldissera, Analu Bender Dos Santos, Paulo Ivo Homem de Bittencourt, Mirna Stela Ludwig, Claudia Ramos Rhoden, Thiago Gomes Heck
Exposure to fine particulate matter (PM2.5) air pollution is a risk factor for type 2 diabetes (T2DM). We argue whether the potentiating effect of PM2.5 over the development of T2DM in high-fat diet (HFD)-fed mice would be related to modification in cell stress response, particularly in antioxidant defenses and 70-kDa heat shock proteins (HSP70) status. Male mice were fed standard chow or HFD for 12 weeks and then randomly exposed to daily nasotropic instillation of PM2.5 for additional 12 weeks under the same diet schedule, divided into four groups (n = 14-15 each): Control, PM2...
June 29, 2016: Journal of Physiology and Biochemistry
Regina Rückerl, Alexandra Schneider, Regina Hampel, Susanne Breitner, Josef Cyrys, Ute Kraus, Jianwei Gu, Jens Soentgen, Wolfgang Koenig, Annette Peters
BACKGROUND AND AIMS: Epidemiological studies have shown adverse effects of ambient air pollutants on health with inflammation and oxidative stress playing an important role. We examine the association between blood biomarkers of inflammation and coagulation and physical attributes of particulate matter which are not routinely measured such as particle length or surface area concentration and apparent density of PM. METHODS: Between 3/2007 and 12/2008 187 non-smoking individuals with type 2 diabetes mellitus (T2D) or impaired glucose tolerance (IGT) were examined within the framework of the KORA Study in Augsburg, Germany...
October 2016: Environmental Research
Ikenna C Eze, Medea Imboden, Ashish Kumar, Arnold von Eckardstein, Daiana Stolz, Margaret W Gerbase, Nino Künzli, Marco Pons, Florian Kronenberg, Christian Schindler, Nicole Probst-Hensch
Exposure to ambient air pollution (AP) exposure has been linked to type 2 diabetes (T2D) risk. Evidence on the impact of T2D genetic variants on AP susceptibility is lacking. Compared to single variants, joint genetic variants contribute substantially to disease risk. We investigated the modification of AP and diabetes association by a genetic risk score (GRS) covering 63 T2D genes in 1524 first follow-up participants of the Swiss cohort study on air pollution and lung and heart diseases in adults. Genome-wide data and covariates were available from a nested asthma case-control study design...
September 2016: Environment International
Cheng Peng, Marie-Abele C Bind, Elena Colicino, Itai Kloog, Hyang-Min Byun, Laura Cantone, Letizia Trevisi, Jia Zhong, Kasey Brennan, Alexandra E Dereix, Pantel S Vokonas, Brent A Coull, Joel D Schwartz, Andrea A Baccarelli
BACKGROUND: In non-diabetic individuals, higher fasting blood glucose (FBG) independently predicts diabetes risk, cardiovascular disease and dementia. Ambient PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) is an emerging determinant of glucose dysregulation. PM2.5 effects and mechanisms are understudied among non-diabetic individuals. OBJECTIVES: Our goals were to investigate whether PM2.5 is associated with increase in FBG and to explore potential mediating roles of epigenetic gene regulation...
May 24, 2016: Environmental Health Perspectives
Maayan Yitshak Sade, Itai Kloog, Idit F Liberty, Joel Schwartz, Victor Novack
CONTEXT: Evidence from recent decades supports a causal association between air pollution (particulate matter <10 μm in diameter [PM10] and PM <2.5 μm in diameter [PM2.5]) and oxidative stress, possibly involving impaired metabolism of glucose and lipids. OBJECTIVE: Using a satellite based model to assess PM exposure at 1-km spatial resolution, we examined the associations between PM and glucose, hemoglobin A1c (HbA1c), and lipids. DESIGN: Population-based retrospective cohort study of a 10-year period...
June 2016: Journal of Clinical Endocrinology and Metabolism
Zhenyu Zhang, Francine Laden, John P Forman, Jaime E Hart
BACKGROUND: Studies have suggested associations between elevated blood pressure and short-term air pollution exposures, but the evidence is mixed regarding long-term exposures on incidence of hypertension. OBJECTIVES: We examined the association of hypertension incidence with long-term residential exposures to ambient particulate matter (PM) and residential distance to roadway. METHODS: We estimated 24-month and cumulative average exposures to PM10, PM2...
September 2016: Environmental Health Perspectives
Angel M Dzhambov, Donka D Dimitrova
Type 2 diabetes mellitus (T2DM) is a growing public health problem in Bulgaria. While individual and lifestyle determinants have been researched; till date there has been no study on environmental risks such as road traffic, noise, and air pollution. As a first step toward designing a large-scale population-based survey, we aimed at exploring the overall associations of prevalent T2DM with exposures to road traffic, noise, and air pollution. A total of 513 residents of Plovdiv city, Bulgaria were recruited...
May 2016: Noise & Health
Cong Liu, Changyuan Yang, Yaohui Zhao, Zongwei Ma, Jun Bi, Yang Liu, Xia Meng, Yafeng Wang, Jing Cai, Haidong Kan, Renjie Chen
BACKGROUND: The evidence for an association between particulate air pollution and type 2 diabetes mellitus (T2DM) in developing countries was very scarce. OBJECTIVE: To investigate the associations of long-term exposure to fine particulate matter (PM2.5) with T2DM prevalence and with fasting glucose and glycosylated hemoglobin (HbA1c) levels in China. METHODS: This is a cross-sectional study based on a nation-wide baseline survey of 11,847 adults who participated in the China Health and Retirement Longitudinal Study from June 2011 to March 2012...
July 2016: Environment International
Eric Lavigne, Abdool S Yasseen, David M Stieb, Perry Hystad, Aaron van Donkelaar, Randall V Martin, Jeffrey R Brook, Daniel L Crouse, Richard T Burnett, Hong Chen, Scott Weichenthal, Markey Johnson, Paul J Villeneuve, Mark Walker
BACKGROUND: Prenatal exposure to ambient air pollution has been associated with adverse birth outcomes, but the potential modifying effect of maternal comorbidities remains understudied. Our objective was to investigate whether associations between prenatal air pollution exposures and birth outcomes differ by maternal comorbidities. METHODS: A total of 818,400 singleton live births were identified in the province of Ontario, Canada from 2005 to 2012. We assigned exposures to fine particulate matter (PM2...
July 2016: Environmental Research
Kyoung-Nam Kim, Youn-Hee Lim, Hyun Joo Bae, Myounghee Kim, Kweon Jung, Yun-Chul Hong
BACKGROUND: Previous studies have associated short-term air pollution exposure with depression. Although an animal study showed an association between long-term exposure to particulate matter ≤2.5 µm (PM2.5) and depression, epidemiological studies assessing the long-term association are scarce. OBJECTIVE: To determine the association between long-term PM2.5 exposure and major depressive disorder (MDD). METHODS: A total of 27,270 participants aged 15-79 years who maintained an address within the same districts in Seoul, Korea throughout the entire study period (between 2002 and 2010) and without a previous MDD diagnosis were analyzed...
April 29, 2016: Environmental Health Perspectives
Petra Haberzettl, Timothy E O'Toole, Aruni Bhatnagar, Daniel J Conklin
BACKGROUND: Epidemiological evidence suggests that exposure to ambient air fine particular matter (PM2.5) increases the risk of developing type 2 diabetes and cardiovascular disease. However, the mechanisms underlying these effects of PM2.5 remain unclear. OBJECTIVES: We tested the hypothesis that PM2.5 exposure decreases vascular insulin sensitivity by inducing pulmonary oxidative stress. METHODS: Mice fed control (10-13% kcal fat) and high-fat (60% kcal fat, HFD) diet, treated with 4-hydroxy-2,2,6,6-tetramethylpiperidine1-oxyl (TEMPOL) or mice overexpressing lung-specific extracellular superoxide dismutase (ecSOD) were exposed to HEPA-filtered air or concentrated PM2...
April 29, 2016: Environmental Health Perspectives
Wenyuan Li, Elissa H Wilker, Kirsten S Dorans, Mary B Rice, Joel Schwartz, Brent A Coull, Petros Koutrakis, Diane R Gold, John F Keaney, Honghuang Lin, Ramachandran S Vasan, Emelia J Benjamin, Murray A Mittleman
BACKGROUND: Short-term exposure to elevated air pollution has been associated with higher risk of acute cardiovascular diseases, with systemic oxidative stress induced by air pollution hypothesized as an important underlying mechanism. However, few community-based studies have assessed this association. METHODS AND RESULTS: Two thousand thirty-five Framingham Offspring Cohort participants living within 50 km of the Harvard Boston Supersite who were not current smokers were included...
May 2016: Journal of the American Heart Association
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