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Particulate matter and diabet

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https://www.readbyqxmd.com/read/28712959/associations-between-long-term-exposure-to-air-pollution-glycosylated-hemoglobin-and-diabetes
#1
Trenton Honda, Vivian C Pun, Justin Manjourides, Helen Suh
BACKGROUND: Air pollution exposures have been shown to adversely impact health through a number of biological pathways associated with glucose metabolism. However, few studies have evaluated the associations between air pollution and glycosylated hemoglobin (HbA1c) levels. Further, no studies have evaluated these associations in US populations or investigated whether associations differ in diabetic as compared to non-diabetic populations. To address this knowledge gap, we investigated the associations between airborne fine particulate matter (PM2...
June 26, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28708100/airborne-pm2-5-induced-hepatic-insulin-resistance-by-nrf2-jnk-mediated-signaling-pathway
#2
Jinxia Xu, Wei Zhang, Zhongbing Lu, Fang Zhang, Wenjun Ding
Animal and epidemiological studies have suggested that exposure to airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM2.5) is associated with the risk of developing type 2 diabetes. However, the mechanism underlying this risk is poorly understood. In the present study, we investigated the effects of PM2.5 exposure on glucose homeostasis and related signaling pathways in mice. Wild-type and nuclear factor erythroid 2-related factor 2 (Nrf2) knockout (Nrf2(-)(/)(-)) C57BL/6 male mice were exposed to either ambient concentrated PM2...
July 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28692015/the-association-between-particulate-matter-air-pollution-and-respiratory-health-in-elderly-with-type-2-diabetes-mellitus
#3
Yanhui Hao, Jing Zhao, Kan Wang, Nannan Feng, Pin Sun, Renjie Chen, Bin Han, Zhipeng Bai, Yiliang Zhu, Ying Gao, Zhao-Lin Xia
OBJECTIVE: We investigated the association between respiratory health and particulate matter (PM) air pollution in elderly type 2 diabetes mellitus (T2DM) pre-, during, and post-the Chinese Lunar New Year (CLNY) holiday in Shanghai, China. METHODS: We conducted repeated measurements of lung function and inflammation biomarker in a cohort consisted of 60 participants with T2DM. RESULTS: Decreased PM2.5 exposure had an effect on respiratory health by increasing in forced expiratory flow in 1 second (FEV1) and forced vital capacity (FVC)...
July 6, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28655143/air-pollution-and-cardiometabolic-disease-an-update-and-call-for-clinical-trials
#4
Robert D Brook, David E Newby, Sanjay Rajagopalan
Fine particulate matter <2.5 µm (PM2.5) air pollution is a leading cause of global morbidity and mortality. The largest portion of deaths is now known to be due to cardiovascular disorders. Several air pollutants can trigger acute events (e.g., myocardial infarctions, strokes, heart failure). However, mounting evidence additionally supports that longer-term exposures pose a greater magnified risk to cardiovascular health. One explanation may be that PM2.5 has proven capable of promoting the development of chronic cardiometabolic conditions including atherosclerosis, hypertension, and diabetes mellitus...
June 24, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28645522/acute-effects-of-ambient-temperature-and-particulate-air-pollution-on-fractional-exhaled-nitric-oxide-a-panel-study-among-diabetic-patients-in-shanghai-china
#5
Huichu Li, Hongjian Bai, Changyuan Yang, Renjie Chen, Cuicui Wang, Zhuohui Zhao, Haidong Kan
BACKGROUND: Epidemiological studies have shown the associations of ambient temperature and particulate matter (PM) air pollution with respiratory morbidity and mortality. However, the underlying mechanisms have not been well characterized. The aim of this study is to investigate the associations of temperature and fine and coarse PM with fractional exhaled nitric oxide (FeNO), a well-established biomarker of respiratory inflammation. METHODS: We conducted a longitudinal panel study involving six repeated FeNO tests among 33 type 2 diabetes mellitus patients from April to June 2013 in Shanghai, China...
June 20, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28578529/particulate-matter-air-pollution-individual-choices-for-improving-cardiometabolic-well-being
#6
Katherine Esposito, Giuseppe Bellastella, Maria Ida Maiorino, Dario Giugliano
Exposure to small particulate matter (PM2.5) has become the 5th highest ranking risk factor for death, responsible for 4.2 million deaths worldwide. PM pollution is also associated with cardiovascular disease and type 2 diabetes, and may contribute to deteriorate the already poor cardiometabolic outlook of the diabetic patient. Although most sources of outdoor air pollution are well beyond the control of individuals, there is still room for personal action. Health behaviors (smoking cessation, avoiding obesity, and increasing physical activity) may increase the poor life expectancy of individuals in the lowest income quartile of the Western population; moreover, a favorable lifestyle, (no current smoking, no obesity, physical activity at least once weekly, and a healthy diet pattern), may cut by nearly 50% the risk of coronary heart disease among people at high genetic risk...
June 3, 2017: Endocrine
https://www.readbyqxmd.com/read/28545656/cord-plasma-insulin-and-in-utero-exposure-to-ambient-air-pollution
#7
Narjes Madhloum, Bram G Janssen, Dries S Martens, Nelly D Saenen, Esmée Bijnens, Wilfried Gyselaers, Joris Penders, Charlotte Vanpoucke, Wouter Lefebvre, Michelle Plusquin, Tim S Nawrot
INTRODUCTION: Cardio-metabolic risk factors including insulin levels are at young age barely perceived as harmful, but over time these risk factors may track and lead to higher risk of metabolic syndrome. Studies showed that exposure to air pollution is associated with an increased risk of insulin resistance in childhood. We determined whether the origin of type 2 diabetes can be found in the early childhood by examining the levels of insulin in the neonatal cord blood and whether this can be considered as a disease marker for later life...
August 2017: Environment International
https://www.readbyqxmd.com/read/28516352/air-pollution-and-respiratory-health-among-diabetic-and-non-diabetic-subjects-in-pune-india-results-from-the-wellcome-trust-genetic-study
#8
Morteza Abdullatif Khafaie, Sundeep Santosh Salvi, Chittaranjan Sakerlal Yajnik, Ajay Ojha, Behzad Khafaie, Sharad Damodar Gore
Diabetics may be more vulnerable to the harmful effects of ambient air pollutants than healthy individuals. But, the risk factors that lead to susceptibility to air pollution in diabetics have not yet been identified. We examined the effect of exposure to ambient PM10 on chronic symptoms and the pulmonary function tests (PFT) in diabetic and non-diabetic subjects. Also, to investigate possible determinants of susceptibility, we recruited 400 type 2 diabetic and 465 healthy subjects who were investigated for chronic respiratory symptoms (CRSs) and then underwent measurement of forced vital capacity (FVC) and forced expiratory volume 1 (FEV1) according to standard protocol...
May 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28493694/community-vulnerability-to-health-impacts-of-wildland-fire-smoke-exposure
#9
Ana G Rappold, Jeanette Reyes, George Pouliot, Wayne E Cascio, David Diaz-Sanchez
Identifying communities vulnerable to adverse health effects from exposure to wildfire smoke may help prepare responses, increase the resilience to smoke and improve public health outcomes during smoke days. We developed a Community Health-Vulnerability Index (CHVI) based on factors known to increase the risks of health effects from air pollution and wildfire smoke exposures. These factors included county prevalence rates for asthma in children and adults, chronic obstructive pulmonary disease, hypertension, diabetes, obesity, percent of population 65 years of age and older, and indicators of socioeconomic status including poverty, education, income and unemployment...
June 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28440694/fine-particulate-matter-pm2-5-a-risk-factor-of-rat-gestational-diabetes-with-altered-blood-glucose-and-pancreatic-glut2-expression
#10
Liu Yi, Chen Wei, Wang Fan
Recent studies have shown an association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter 2 (GLUT2) expression and its related mechanisms in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose while the controls received saline. Interleukin-6 (IL-6) and blood routine tests (BRT) were detected for analyzing coagulation and inflammation. Pancreas tissues underwent pathologic examination, the levels of homogenate glutathione peroxidase (GSH-Px), and methane dicarboxylic aldehyde (MDA) were detected for oxidative stress estimation, and the degree of GLUT2 expression of pancreas was analyzed...
April 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28435814/gender-dependent-differences-in-the-relationship-between-diabetes-mellitus-and-ambient-air-pollution-among-adults-in-south-korean-cities
#11
Dongwook Sohn, Hyunjin Oh
BACKGROUND: Air pollution has been a serious public health threat worldwide. It has been linked to pulmonary and cardiovascular diseases but is also believed to contribute to air-pollution-mediated cardiometabolic disease such as diabetes. We investigated the relationship between type 2 diabetes mellitus (DM2) and air pollution in densely developed urban settings in South Korea, using national epidemiologic data. METHODS: The analysis focused on examining gender-related differences in the relationship between DM 2 and air pollutants, specifically particulate matter ≤ 10μm (PM10) and sulfur dioxide (SO2)...
March 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28429404/air-pollution-weight-loss-and-metabolic-benefits-of-bariatric-surgery-a-potential-model-for-study-of-metabolic-effects-of-environmental-exposures
#12
R Ghosh, W J Gauderman, H Minor, H A Youn, F Lurmann, K R Cromar, L Chatzi, B Belcher, C R Fielding, R McConnell
BACKGROUND: Emerging experimental evidence suggests that air pollution may contribute to development of obesity and diabetes, but studies of children are limited. OBJECTIVES: We hypothesized that pollution effects would be magnified after bariatric surgery for treatment of obesity, reducing benefits of surgery. METHODS: In 75 obese adolescents, excess weight loss (EWL), high-density lipoprotein (HDL) cholesterol, triglycerides, alkaline phosphatase (ALP) and hemoglobin A1c (HbA1c ) were measured prospectively at baseline and following laparoscopic adjustable gastric banding (LAGB)...
April 21, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28420118/ambient-air-pollution-and-out-of-hospital-cardiac-arrest-in-beijing-china
#13
Ruixue Xia, Guopeng Zhou, Tong Zhu, Xueying Li, Guangfa Wang
Air pollutants are associated with cardiovascular death; however, there is limited evidence of the effects of different pollutants on out-of-hospital cardiac arrests (OHCAs) in Beijing, China. We aimed to investigate the associations of OHCAs with the air pollutants PM2.5-10 (coarse particulate matter), PM2.5 (particles ≤2.5 μm in aerodynamic diameter), nitrogen dioxide (NO₂), sulfur dioxide (SO₂), carbon monoxide (CO), and ozone (O₃) between 2013 and 2015 using a time-stratified case-crossover study design...
April 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28411585/the-association-between-air-pollution-and-type-2-diabetes-in-a-large-cross-sectional-study-in-leicester-the-champions-study
#14
Gary O'Donovan, Yogini Chudasama, Samuel Grocock, Roland Leigh, Alice M Dalton, Laura J Gray, Thomas Yates, Charlotte Edwardson, Sian Hill, Joe Henson, David Webb, Kamlesh Khunti, Melanie J Davies, Andrew P Jones, Danielle H Bodicoat, Alan Wells
BACKGROUND: Observational evidence suggests there is an association between air pollution and type 2 diabetes; however, there is high risk of bias. OBJECTIVE: To investigate the association between air pollution and type 2 diabetes, while reducing bias due to exposure assessment, outcome assessment, and confounder assessment. METHODS: Data were collected from 10,443 participants in three diabetes screening studies in Leicestershire, UK. Exposure assessment included standard, prevailing estimates of outdoor nitrogen dioxide and particulate matter concentrations in a 1×1km area at the participant's home postcode...
April 12, 2017: Environment International
https://www.readbyqxmd.com/read/28368218/fine-particulate-matter-pm2-5-a-risk-factor-for-rat-gestational-diabetes-with-altered-blood-glucose-and-pancreatic-glut2-expression
#15
Liu Yi, Chen Wei, Wang Fan
Recent studies have shown an intriguing association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter2 (GLUT2) expression in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose during pregnancy. After exposure, interleukin-6 (IL-6) and blood routine tests (BRT) were detected. Pancreas underwent pathologic examination. The levels of pancreatic homogenate glutathione peroxidase (GSH-Px), methane dicarboxylic aldehyde (MDA) and GLUT2 were detected...
April 3, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28346907/long-term-associations-of-modeled-and-self-reported-measures-of-exposure-to-air-pollution-and-noise-at-residence-on-prevalent-hypertension-and-blood-pressure
#16
Anitha Pitchika, Regina Hampel, Kathrin Wolf, Ute Kraus, Josef Cyrys, Wolfgang Babisch, Annette Peters, Alexandra Schneider
Air pollution, traffic noise and noise annoyance are suggested to be associated with hypertension and blood pressure (BP); however, the evidence remains inconsistent. Our study examined the long-term associations of modeled and self-reported measures of air pollution and traffic noise on prevalent hypertension and BP. We analyzed cross-sectional data from 2552 participants aged 31-72years from the KORA F4 (2006-2008) study conducted in the region of Augsburg, Germany. Land-use regression models were used to estimate residential long-term exposure to particulate matter <2...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28212639/erectile-dysfunction-and-exposure-to-ambient-air-pollution-in-a-nationally-representative-cohort-of-older-men
#17
Lindsay A Tallon, Justin Manjourides, Vivian C Pun, Murray A Mittleman, Marianthi-Anna Kioumourtzoglou, Brent Coull, Helen Suh
BACKGROUND: Little is known about the association between air pollution and erectile dysfunction (ED), a disorder occurring in 64% of men over the age of 70, and to date, no studies have been published. To address this significant knowledge gap, we explored the relationship between ED and air pollution in a group of older men who were part of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative cohort study of older Americans. METHODS: We obtained incident ED status and participant data for 412 men (age 57-85)...
February 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28169030/association-of-pm2-5-with-diabetes-asthma-and-high-blood-pressure-incidence-in-canada-a-spatiotemporal-analysis-of-the-impacts-of-the-energy-generation-and-fuel-sales
#18
Weeberb J Requia, Matthew D Adams, Petros Koutrakis
Numerous studies have reported an association between fine particulate matter (PM2.5) and human health. Often these relationships are influenced by environmental factor that varies spatially and/or temporally. To our knowledge, there are no studies in Canada that have considered energy generation and fuel sales as PM2.5 effects modifiers. Determining exposure and disease-specific risk factors over space and time is crucial for disease prevention and control. In this study, we evaluated the association of PM2...
April 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28153529/ambient-ozone-and-incident-diabetes-a-prospective-analysis-in-a-large-cohort-of-african-american-women
#19
Michael Jerrett, Robert Brook, Laura F White, Richard T Burnett, Jeffrey Yu, Jason Su, Edmund Seto, Julian Marshall, Julie R Palmer, Lynn Rosenberg, Patricia F Coogan
BACKGROUND: Ozone is a ubiquitous air pollutant with increasing concentrations in many populous regions. Toxicological studies show that ozone can cause oxidative stress and increase insulin resistance. These pathways may contribute to metabolic changes and diabetes formation. In this paper, we investigate the association between ozone and incident type 2 diabetes in a large cohort of African American women. METHODS: We used Cox proportional hazards models to calculate hazard ratios (HRs) for incident type 2 diabetes associated with exposure to ozone in a cohort of 45,231 African American women living in 56 metropolitan areas across the United States...
May 2017: Environment International
https://www.readbyqxmd.com/read/28142053/interactions-between-cigarette-smoking-and-ambient-pm2-5-for-cardiovascular-mortality
#20
Michelle C Turner, Aaron Cohen, Richard T Burnett, Michael Jerrett, W Ryan Diver, Susan M Gapstur, Daniel Krewski, Jonathan M Samet, C Arden Pope
Associations between long-term exposure to ambient fine particulate matter (PM2.5) and all-cause and cardiovascular mortality are well documented however less is known regarding possible interactions with cigarette smoking. We previously reported a supra-additive synergistic relationship between PM2.5 and cigarette smoking for lung cancer mortality. Here we examine interactions for all-cause and cardiovascular mortality among 429,406 current or never smoking participants in the prospective American Cancer Society Cancer Prevention Study-II with modeled PM2...
April 2017: Environmental Research
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