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Pollution and microRNA

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https://www.readbyqxmd.com/read/29757566/-traffic-related-air-pollution-and-allergic-rhinitis
#1
REVIEW
Guo Liu, Shi Xi Liu
Exposure to traffic-related air pollutants(TRAP)has been implicated in airway allergic diseases.Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of TRAP on allergic rhinitis(AR)and the biology underlying this impact.These studies have found that oxidative stress induced by TRAP could affect the axis of epithelial cell-dendritic cell-T cell towards a T-helper 2 immune response,which is the major mechanism between TRAP and AR.Further,epigenetics and microRNA might be involved in this process...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29752874/intrinsic-and-extrinsic-regulation-of-human-skin-melanogenesis-and-pigmentation
#2
REVIEW
Catherine Serre, Valère Busuttil, Jean-Marie Botto
In human skin, melanogenesis is a tightly regulated process. Indeed, several extracellular signals are transduced via dedicated signaling pathways and mostly converge to MITF, a transcription factor integrating upstream signaling and regulating downstream genes involved in the various inherent mechanisms modulating melanogenesis. The synthesis of melanin pigments occurs in melanocytes inside melanosomes where melanogenic enzymes (tyrosinase and related proteins) are addressed with the help of specific protein complexes...
May 12, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29750581/cftr-dysfunction-in-cystic-fibrosis-and-chronic-obstructive-pulmonary-disease
#3
Elena Fernandez Fernandez, Chiara de Santi, Virginia De Rose, Catherine M Greene
Obstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) are causes of high morbidity and mortality worldwide. CF is a multiorgan genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and is characterized by progressive chronic obstructive lung disease. Most cases of COPD are a result of noxious particles, mainly cigarette smoke but also other environmental pollutants. Areas covered: Although the pathogenesis and pathophysiology of CF and COPD differ, they do share key phenotypic features and because of these similarities there is great interest in exploring common mechanisms and/or factors affected by CFTR mutations and environmental insults involved in COPD...
May 11, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29739446/sex-specific-microrna-expression-networks-in-an-acute-mouse-model-of-ozone-induced-lung-inflammation
#4
Nathalie Fuentes, Arpan Roy, Vikas Mishra, Noe Cabello, Patricia Silveyra
BACKGROUND: Sex differences in the incidence and prognosis of respiratory diseases have been reported. Studies have shown that women are at increased risk of adverse health outcomes from air pollution than men, but sex-specific immune gene expression patterns and regulatory networks have not been well studied in the lung. MicroRNAs (miRNAs) are environmentally sensitive posttranscriptional regulators of gene expression that may mediate the damaging effects of inhaled pollutants in the lung, by altering the expression of innate immunity molecules...
May 8, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29725457/function-of-pm2-5-in-the-pathogenesis-of-lung-cancer-and-chronic-airway-inflammatory-diseases
#5
REVIEW
Ruyi Li, Rui Zhou, Jiange Zhang
Previous research has identified that air pollution is associated with various respiratory diseases, but few studies have investigated the function served by particulate matter 2.5 (PM2.5) in these diseases. PM2.5 is known to cause epigenetic and microenvironmental alterations in lung cancer, including tumor-associated signaling pathway activation mediated by microRNA dysregulation, DNA methylation, and increased levels of cytokines and inflammatory cells. Autophagy and apoptosis of tumor cells may also be detected in lung cancer associated with PM2...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29676639/effects-of-controlled-diesel-exhaust-and-allergen-exposure-on-microrna-and-gene-expression-in-humans-modulation-of-lung-inflammatory-markers-associated-with-asthma
#6
Christopher F Rider, Masatsugu Yamamoto, Oliver P Günther, Amrit Singh, Jeremy A Hirota, Scott J Tebbutt, Christopher Carlsten
RATIONALE: Air pollution may contribute to the development of allergic diseases, including asthma, by enhancing immune responses to allergen, but the effects on microRNA, messenger RNA, and inflammatory markers remain unexplored. OBJECTIVES: To determine if acute exposure to diesel exhaust and/or allergen alters expression of microRNA and genes with effects on inflammatory markers associated with asthma. METHODS: Fifteen atopic participants were exposed in a crossover trial to inhaled filtered air or diesel exhaust (DE; 300 μg particulate matter with aerodynamic diameter less than or equal to 2...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29547640/silencing-of-haace1-gene-by-host-delivered-artificial-microrna-disrupts-growth-and-development-of-helicoverpa-armigera
#7
Ravi Prakash Saini, Venkat Raman, Gurusamy Dhandapani, Era Vaidya Malhotra, Rohini Sreevathsa, Polumetla Ananda Kumar, Tilak R Sharma, Debasis Pattanayak
The polyphagous insect-pest, Helicoverpa armigera, is a serious threat to a number of economically important crops. Chemical application and/or cultivation of Bt transgenic crops are the two strategies available now for insect-pest management. However, environmental pollution and long-term sustainability are major concerns against these two options. RNAi is now considered as a promising technology to complement Bt to tackle insect-pests menace. In this study, we report host-delivered silencing of HaAce1 gene, encoding the predominant isoform of H...
2018: PloS One
https://www.readbyqxmd.com/read/29543730/cadmium-nephrotoxicity-is-associated-with-altered-microrna-expression-in-the-rat-renal-cortex
#8
Michael J Fay, Lauren A C Alt, Dominika Ryba, Ribhi Salamah, Ryan Peach, Alexander Papaeliou, Sabina Zawadzka, Andrew Weiss, Nil Patel, Asad Rahman, Zyaria Stubbs-Russell, Peter C Lamar, Joshua R Edwards, Walter C Prozialeck
Cadmium (Cd) is a nephrotoxic environmental pollutant that causes a generalized dysfunction of the proximal tubule characterized by polyuria and proteinuria. Even though the effects of Cd on the kidney have been well-characterized, the molecular mechanisms underlying these effects have not been fully elucidated. MicroRNAs (miRNAs) are small non-coding RNAs that regulate cellular and physiologic function by modulating gene expression at the post-transcriptional level. The goal of the present study was to determine if Cd affects renal cortex miRNA expression in a well-established animal model of Cd-induced kidney injury...
March 15, 2018: Toxics
https://www.readbyqxmd.com/read/29535514/the-effect-of-environmental-factors-on-the-differential-expression-of-mirnas-in-patients-with-chronic-obstructive-pulmonary-disease-a-pilot-clinical-study
#9
Peng-Fei Liu, Peng Yan, Da-Hui Zhao, Wen-Fang Shi, Song Meng, Yang Liu, Bin Liu, Guo-Feng Li, Li-Xin Xie
Objective: The objective of the study was to analyze the effect of environmental factors on the differential expression of microRNAs in the peripheral blood of migratory and local patients in northern People's Republic of China and on clinical symptoms of local patients in northern People's Republic of China with COPD. Methods: A total of 118 patients in the northern region and 8 migratory patients were enrolled in this prospective study. We collected general information...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29406108/dioxin-induces-expression-of-hsa-mir-146b-5p-in-human-neuroblastoma-cells
#10
Tuan Xu, Heidi Q Xie, Yunping Li, Yingjie Xia, Rui Sha, Lingyun Wang, Yangsheng Chen, Li Xu, Bin Zhao
Dioxin can cause a series of neural toxicological effects. MicroRNAs (miRs) play important roles in regulating nervous system function and mediating cellular responses to environmental pollutants, such as dioxin. Hsa-miR-146b-5p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-miR-146b-5p. We found that the hsa-miR-146b-5p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line...
January 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29369067/evidence-establishing-a-link-between-prenatal-and-early-life-stress-and-asthma-development
#11
Maria José Rosa, Alison G Lee, Rosalind J Wright
PURPOSE OF REVIEW: The objective of this review is to provide an update on our evolving understanding of the effects of stress in pregnancy and during early development on the onset of asthma-related phenotypes across childhood, adolescence, and into early adulthood. RECENT FINDINGS: Accumulating evidence over the past 2 decades has established that prenatal and early-life psychological stress and stress correlates (e.g., maternal anxiety or depression) increase the risk for childhood respiratory disorders...
January 23, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29342453/fine-particulate-air-pollution-and-the-expression-of-micrornas-and-circulating-cytokines-relevant-to-inflammation-coagulation-and-vasoconstriction
#12
Renjie Chen, Huichu Li, Jing Cai, Cuicui Wang, Zhijing Lin, Cong Liu, Yue Niu, Zhuohui Zhao, Weihua Li, Haidong Kan
BACKGROUND: MicroRNAs (miRNAs) are a key factor in epigenetic regulation of gene expression, but miRNA responses to fine particulate matter (PM2.5) air pollution and their potential contribution to cardiovascular effects of PM2.5 are unknown. OBJECTIVE: We explored the potential influence of PM2.5 on the expression of selected cytokines relevant to systemic inflammation, coagulation, and vasoconstriction, and on miRNAs that may regulate their expression. METHODS: We designed a double-blind, randomized crossover study in which true and sham air purifiers were used to expose 55 healthy young adult students in Shanghai, China, to reduced or ambient levels of indoor PM2...
January 17, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29329427/ozone-induced-vascular-contractility-and-pulmonary-injury-are-differentially-impacted-by-diets-enriched-with-coconut-oil-fish-oil-and-olive-oil
#13
Samantha J Snow, Wan-Yun Cheng, Andres Henriquez, Myles Hodge, Virgina Bass, Gail M Nelson, Gleta Carswell, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Brian Chorley, Kymberly M Gowdy, Haiyan Tong, Urmila P Kodavanti
Fish, olive, and coconut oil dietary supplementation have several cardioprotective benefits, but it is not established if they protect against air pollution-induced adverse effects. We hypothesized that these dietary supplements would attenuate ozone-induced systemic and pulmonary effects. Male Wistar Kyoto rats were fed either a normal diet, or a diet supplemented with fish, olive, or coconut oil for 8 weeks. Animals were then exposed to air or ozone (0.8 ppm), 4 h/day for 2 days. Ozone exposure increased phenylephrine-induced aortic vasocontraction, which was completely abolished in rats fed the fish oil diet...
May 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29278923/environmental-stressors-and-their-impact-on-health-and-disease-with-focus-on-oxidative-stress
#14
EDITORIAL
Thomas Münzel, Andreas Daiber
Epidemiological, preclinical and interventional clinical studies have demonstrated that environmental stressors are associated with health problems, namely cardiovascular diseases. According to estimations of the World Health Organization (WHO), environmental risk factors account for an appreciable part of global deaths and life years spent with disability. This Forum addresses the impact of the environmental risk factors such as traffic noise exposure, air pollution by particulate matter (PM), mental stress/loneliness, and the life style risk factor (water-pipe) smoking on health and disease with focus on the cardiovascular system...
March 20, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29096313/regulation-of-pregnane-x-receptor-and-micrornas-on-detoxification-related-genes-expressions-in-mugilogobius-abei-under-the-exposure-to-diclofenac
#15
Peijia Ku, Chao Wang, Xiangping Nie, Ruikang Ou, Kaibing Li
Diclofenac (DCF) has been recognized as an emerging contaminant in aquatic environments. Though many studies have investigated the toxic effects of DCF in human and mammals, limited information is available for the responses of genes associated with detoxification metabolisms in non-target aquatic organisms such as fish. In the present study, a small benthic fish Mugilogobius abei, was chosen as the test organism and the effects of DCF on detoxification-related genes at transcriptional level in M. abei were investigated...
February 2018: Environmental Pollution
https://www.readbyqxmd.com/read/28899404/extracellular-vesicle-packaged-mirna-release-after-short-term-exposure-to-particulate-matter-is-associated-with-increased-coagulation
#16
Laura Pergoli, Laura Cantone, Chiara Favero, Laura Angelici, Simona Iodice, Eva Pinatel, Mirjam Hoxha, Laura Dioni, Marilena Letizia, Benedetta Albetti, Letizia Tarantini, Federica Rota, Pier Alberto Bertazzi, Amedea Silvia Tirelli, Vincenza Dolo, Andrea Cattaneo, Luisella Vigna, Cristina Battaglia, Michele Carugno, Matteo Bonzini, Angela Cecilia Pesatori, Valentina Bollati
BACKGROUND: Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and increased coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases. Extracellular vesicles (EVs), which travel in body fluids and transfer microRNAs (miRNAs) between tissues, might play an important role in PM-induced cardiovascular risk...
August 24, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28846189/the-mechanisms-for-lung-cancer-risk-of-pm-2-5-induction-of-epithelial-mesenchymal-transition-and-cancer-stem-cell-properties-in-human-non-small-cell-lung-cancer-cells
#17
Hongying Wei, Fan Liang, Wei Cheng, Ren Zhou, Xiaomeng Wu, Yan Feng, Yan Wang
Fine particulate matter (PM2.5 ) is a major component of air pollutions that are closely associated with increased risk of lung cancer. However, the role of PM2.5 in the etiology of lung cancer is largely unknown. In this study, we performed acute (24 hours) and chronic (five passages) exposure models to investigate the carcinogenetic mechanisms of PM2.5 by targeting the induction of epithelial-mesenchymal transition (EMT) and cancer stem cells (CSC) properties in human non-small cell lung cancer cell line A549...
November 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28835693/microrna-profile-for-health-risk-assessment-environmental-exposure-to-persistent-organic-pollutants-strongly-affects-the-human-blood-microrna-machinery
#18
Julian Krauskopf, Theo M de Kok, Dennie G Hebels, Ingvar A Bergdahl, Anders Johansson, Florentin Spaeth, Hannu Kiviranta, Panu Rantakokko, Soterios A Kyrtopoulos, Jos C Kleinjans
Persistent organic pollutants (POPs) are synthetic chemical substances that accumulate in our environment. POPs such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB) and dichlorodiphenyltrichloroethane (DDT) have been classified as carcinogenic to humans and animals. Due to their resistance to biodegradation humans are still exposed to these compounds worldwide. We aim to evaluate the miRNA and transcriptomic response of a human population exposed to POPs. The miRNA and transcriptomic response was measured in blood of healthy subjects by microarray technology and associated with the serum concentrations of six PCB congeners, DDE (a common DDT metabolite), and HCB...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819808/mir398-and-mir395-are-involved-in-response-to-so-2-stress-in-arabidopsis-thaliana
#19
Lihong Li, Huilan Yi, Meizhao Xue, Min Yi
Sulfur dioxide (SO2 ) is a common air pollutant that has adverse effects on plants. MicroRNAs (miRNAs) are small noncoding RNA that play critical roles in plant development and stress response. In this study, we found that two miRNAs, miR398 and miR395, were differentially expressed in Arabidopsis shoots under SO2 stress. The expression of miR398 was down-regulated, and the transcript levels of its target genes, Cu/Zn superoxide dismutases (CSD1 and CSD2), were increased during SO2 exposure. The activity of superoxide dismutase (SOD), one of the major antioxidant enzymes, was enhanced with the increase in the CSD transcript level, suggesting an important role of miR398 in response to SO2 -induced oxidative stress...
November 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28818587/phenanthrene-responsive-micrornas-and-their-targets-in-wheat-roots
#20
Jinfeng Li, Le Yue, Yu Shen, Yu Sheng, Xinhua Zhan, Guohua Xu, Baoshan Xing
MicroRNAs (miRNAs) play key roles in plant growth, development and responses to abiotic stress. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants. However, it is yet unknown how miRNAs work during PAH uptake by plant roots. Thus, in this study we ascertain phenanthrene (a model PAH)-responsive miRNAs using small RNA high-throughput deep sequencing and their target genes in wheat roots. We identified 108 conserved and non-conserved miRNA members belonging to 82 miRNA families and found 11 differentially expressed miRNAs, among which four miRNAs (miR156, miR164, miR171a and miR9678-3p) were up-regulated and the other seven miRNAs (miR398, miR531, miR1121, miR5048-5p, miR9653b, miR9773 and miR9778) were down-regulated...
November 2017: Chemosphere
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