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Limin Xia, Ping Mo, Wenjie Huang, Lin Zhang, Ying Wang, Hongwu Zhu, Dean Tian, Jian Liu, Zhangqian Chen, Yongguo Zhang, Zheng Chen, Hao Hu, Daiming Fan, Yongzhan Nie, Kaichun Wu
The proliferation-specific transcription factor Forkhead box M1 (FoxM1) acts as a master regulator of cancer cell growth and survival and plays an important role in the development of hepatocellular carcinoma. However, the molecular mechanisms that regulate FoxM1 expression remain largely unknown. In the current study, we demonstrated that tumor necrosis factor (TNF)-αα induced FoxM1 expression and transactivated its promoter activity in hepatoma cells. Serial 5" deletion and site-directed mutagenesis revealed that the induction of FoxM1 expression by TNF-α was dependent upon the hypoxia-inducible factor 1 (HIF1)-1 and HIF1-3/4 binding sites within the FoxM1 promoter...
November 2012: Carcinogenesis
Aarti Raghavan, Guofei Zhou, Qiyuan Zhou, Joyce Christina F Ibe, Ramaswamy Ramchandran, Qiwei Yang, Harini Racherla, Pradip Raychaudhuri, J Usha Raj
Pulmonary arterial hypertension (PAH) is a devastating disease, and no effective treatments are available. Hypoxia-induced pulmonary artery remodeling, including smooth muscle cell proliferation, contributes to PAH, but the exact mechanisms underlying this abnormal process are largely undefined. The forkhead box M1 (FoxM1) transcription factor regulates cancer cell growth by modulating gene expression critical for cell cycle progression. Here, we report for the first time, to the best of our knowledge, a novel function of FoxM1 in the hypoxia-stimulated proliferation of human pulmonary artery smooth muscle cells (HPASMCs)...
April 2012: American Journal of Respiratory Cell and Molecular Biology
Li-Min Xia, Wen-Jie Huang, Bo Wang, Mei Liu, Qiong Zhang, Wei Yan, Qian Zhu, Min Luo, Zhen-Zhen Zhou, De-An Tian
The proliferation-specific Forkhead box M1 (FoxM1) transcription factor is overexpressed in cancer cells and acts as an important regulator of cancer cell growth and survival. Here, we show the molecular mechanisms by which hypoxia regulate FoxM1 expression in cancer cells. When cells were subjected to hypoxia (1% O2), the mRNA and protein levels of FoxM1 had a significant increase in cancer cells (HepG2, MCF-7, and HeLa). Such increase was due to the direct binding of hypoxia-inducible factor 1 (HIF-1) to the HIF-1 binding sites in the FoxM1 promoter...
February 1, 2009: Journal of Cellular Biochemistry
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