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https://www.readbyqxmd.com/read/29772814/chronic-and-occult-hepatitis-b-virus-infection-in-pregnant-women-in-botswana
#1
Tshepiso Mbangiwa, Ishmael Kasvosve, Motswedi Anderson, Prisca K Thami, Wonderful T Choga, Austen Needleman, Bonolo B Phinius, Sikhulile Moyo, Melvin Leteane, Jean Leidner, Jason T Blackard, Gloria Mayondi, Betsy Kammerer, Rosemary M Musonda, Max Essex, Shahin Lockman, Simani Gaseitsiwe
The hepatitis B virus (HBV) is a global problem; however, the burden of HBV infection in pregnant women in Botswana is unknown. We sought to determine the prevalence of chronic and occult HBV infection in human immunodeficiency virus (HIV)-infected and -uninfected pregnant women in Botswana. Samples from 752 pregnant women were tested for hepatitis B surface antigen (HBsAg), and HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) and HBV DNA load. Samples that were HBsAg negative were screened for occult HBV infection by determining the HBV DNA load...
May 17, 2018: Genes
https://www.readbyqxmd.com/read/29771873/community-based-services-to-improve-testing-and-linkage-to-care-among-non-u-s-born-persons-with-chronic-hepatitis-b-virus-infection-three-u-s-programs-october-2014-september-2017
#2
Aaron M Harris, Ruth Link-Gelles, Karen Kim, Edwin Chandrasekar, Su Wang, Nicole Bannister, Perry Pong, Eric Chak, Moon S Chen, Christopher Bowlus, Noele P Nelson
Among an estimated 850,000 to 2.2 million persons with chronic hepatitis B virus (HBV) infection in the United States, 70% are non-U.S.-born (1,2). All patients require linkage to care, and approximately 20%-40% require antiviral treatment (3). Without treatment, one in four persons chronically infected with HBV will die prematurely from liver failure, liver cirrhosis, or hepatocellular carcinoma (4). To mitigate morbidity and mortality, CDC funded a cooperative agreement to develop hepatitis B testing and linkage-to-care programs serving non-U...
May 18, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29770662/-construction-and-expression-of-multi-gene-recombinant-plasmid-peg-fp-n1-hbsag-rop2
#3
Ma Rong, Xiao Ting, Li Jin, Sun Hui, Xu Chao, Huang Bing-Cheng, Yin Kun, Zhao Gui-Hua, Cui Yong, Zhu Song, Liu Gong-Zhen, Yan Ge, Wei Qing-Kuan
OBJECTIVE: To construct pEGFP-N1-HBsAg-ROP2 recombinant expression plasmid and transfect HEK293T cells for expression, and pay a way for Toxoplasma gondii nucleic acid vaccine development. METHODS: According to the HBsAg gene sequence and pcDNA3-p30-ROP2 recombinant plasmid restriction sites, the HBsAg gene was amplified by PCR. The HBsAg gene was cloned into the pcDNA3-p30-ROP2 and instead of p30 gene. The HBsAg-ROP2 fragment was amplified by PCR and digested with Hind Ⅲ and Kpn Ⅰ to clone into the pEGFP-N1 eukaryotic expression vector and construct the recombinant pEGFP-N1-HBsAg-ROP2...
March 14, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29768691/detection-of-hepatitis-b-virus-dna-among-chronic-and-potential-occult-hbv-patients-in-resource-limited-settings-by-loop-mediated-isothermal-amplification-assay
#4
Arifa Akram, S M Rashedul Islam, Saif Ullah Munshi, Shahina Tabassum
Transmission of Hepatitis B Virus (HBV) usually occurs due to the transfusion of blood or blood products from chronic HBV (CHB) or occult HBV infected (OBI) patients. Besides serological tests e.g. HBsAg and anti-HBc (total), detection of HBV-DNA is necessary for the diagnosis of OBI patients. Different nucleic acid tests (NATs) including real-time-Polymerase Chain Reaction (qPCR) are used for the detect HBV-DNA. The NATs are expensive and require technical expertise which are barriers to introducing them in resource-limited settings...
May 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29767761/significance-of-hbv-nat-among-hbs-antigen-negative-blood-donors-in-saudi-arabia
#5
Nessrin Ghazi Alabdallat, Abdul Aziz A Bin Dukhyil
Background: Bloodborne hepatitis B virus (HBV) transmission from asymptomatic donors with acute HBV infections who have undetectable surface antigen of HBV (HBsAg), or from donors with chronic infections in whom serological markers were not detected, could cause residual infections leading to relevant transfusion-transmitted infections (RTTIs). HBV nucleic acid testing (NAT) can detect HBV DNA in the HBsAg-negative and total hepatitis B core antibody (anti-HBc)-negative window period of infection and in chronic cases...
May 15, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29766002/influence-of-vitamin-d-receptor-gene-polymorphisms-on-response-to-pegylated-interferon-in-chronic-hepatitis-b-egyptian-patients
#6
Gomaa Mostafa-Hedeab, Dina Sabry, Ghada Mostafa Abdelaziz, Manal Ewaiss, Nagla Adli, Wael Fathy
Background: We explored the effect of vitamin D receptor gene ( VDR ) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 µg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels and hepatitis B surface antigen (HBsAg) expression were assessed by ELISA. VDR polymorphisms FokI T>C (rs 10735810), BsmI A>G (rs 1544410), ApaI (rs7975253), and TaqI C>T (rs 731236), were genotyped using real-time PCR...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29765238/higher-baseline-viral-diversity-correlates-with-lower-hbsag-decline-following-pegylated-interferon-alpha-therapy-in-patients-with-hbeag-positive-chronic-hepatitis-b
#7
Hu Li, Li Zhang, Hong Ren, Peng Hu
Background: Viral diversity seems to predict treatment outcomes in certain viral infections. The aim of this study was to evaluate the association between baseline intra-patient viral diversity and hepatitis B surface antigen (HBsAg) decline following PEGylated interferon-alpha (Peg-IFN-α) therapy. Patients and methods: Twenty-six HBeAg-positive patients who were treated with Peg-IFN-α were enrolled. Nested polymerase chain reaction (PCR), cloning, and sequencing of the hepatitis B virus S gene were performed on baseline samples, and normalized Shannon entropy (Sn) was calculated as a measure of small hepatitis B surface protein (SHBs) diversity...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29763447/hepatitis-b-and-c-seroprevalence-knowledge-practice-and-associated-factors-among-medicine-and-health-science-students-in-northeast-ethiopia
#8
Wondmagegn Demsiss, Abdurahaman Seid, Temesgen Fiseha
BACKGROUND: Health care professionals, especially medical students, are at greater risk of contracting hepatitis B and C virus infections due to their occupational exposure to percutaneous injuries and other body fluids. The aim of this study was to determine the seroprevalence of hepatitis B and C virus infections among medicine and health science students in Northeast Ethiopia and to assess their knowledge and practice towards the occupational risk of viral hepatitis. METHODS: A cross-sectional study was conducted among a total of 408 medicine and health science students during the period from March to September 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29761899/the-use-of-hepatitis-b-immunoglobulin-with-or-without-hepatitis-b-vaccine-to-prevent-de-novo-hepatitis-b-in-pediatric-recipients-of-anti-hbc-positive-livers
#9
Noriyo Yamashiki, Atsushi Yoshizawa, Yoshihide Ueda, Toshimi Kaido, Hideaki Okajima, Hiroyuki Marusawa, Hiroshi Seno, Shinji Uemoto
Prophylactic measures are used to reduce DNHB after HBsAg-negative patients receive anti-HBc-positive liver grafts. This study investigated the incidence of DNHB and clinical outcomes in pediatric LT recipients under HBIG prophylaxis, with or without hepatitis B vaccination. Between 1995 and 2013, 51 HBsAg-negative pediatric recipients underwent living-donor LT from anti-HBc-positive donors. The median (range) age was 4 (0.1-17) years, 23 (45%) were male, and 71% were negative for both anti-HBc and anti-HBc...
May 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29761374/the-prognostic-role-of-hbv-infection-in-chronic-lymphocytic-leukemia
#10
Jin-Hua Liang, Rui Gao, Jun-Cheng Dai, Robert Peter Gale, Wang Li, Lei Fan, Zhi-Bin Hu, Wei Xu, Jian-Yong Li
PURPOSE: We attempt to assess the impact of hepatis-B virus (HBV) status on the prognosis of chronic lymphocytic leukemia (CLL) using a Chinese case cohort. METHODS: Five hundred and one consecutive newly diagnosed subjects with CLL were enrolled in this case cohort. HBV infection was defined as hepatitis B surface antigen (HBsAg) positive or hepatitis-B core antibody (HBcAb) positive. Univariate and stepwise multivariate Cox regression analyses were used to screen the prognostic risk factors associated with the end point of time-to-treatment (TTT) or overall survival (OS)...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29761292/-chronic-hepatitis-b-and-d-delta-current-and-future-treatments
#11
REVIEW
N Wortmann, C Höner Zu Siederdissen, M Cornberg
BACKGROUND: Worldwide, hepatitis B virus (HBV) infection is among the 30 leading causes of death, despite effective vaccination and therapeutic options. Chronic hepatitis delta (coinfection with hepatitis D virus) leads to a rapid disease progression. AIMS: Based on current international guidelines and studies, an overview about present and future therapeutic options for chronic hepatitis B and delta is provided. RESULTS: Therapy with nucleoside or nucleotide analogues leads to nearly complete HBV DNA suppression, which is associated with regression of liver fibrosis and a lower risk for the development of hepatocellular carcinoma...
May 14, 2018: Der Internist
https://www.readbyqxmd.com/read/29760795/capable-infection-of-hepatitis-b-virus-in-diffuse-large-b-cell-lymphoma
#12
Yanchun Wang, Huijie Wang, Shaokun Pan, Tao Hu, Jiabin Shen, Hui Zheng, Suhong Xie, Youhua Xie, Renquan Lu, Lin Guo
Background: Diffuse large B-cell lymphoma (DLBCL) is the most common pathological type of non-Hodgkin lymphoma (NHL). It is strongly correlated to the host immunity and infection status. Aim: This study tested the hypothesis that hepatitis B virus (HBV) infection is also associated with DLBCL. Methods: Clinical analysis of the correlation between DLBCL and HBV infection, detection of HBV in situ of DLBCL tissue, and biological experiments that determined whether HBV infects B lymphocytes were conducted. Results: Our long-term clinical data showed that the positive rate of serum HBV was significantly increased in DLBCL patients (23...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29760793/hepatitis-b-virus-infection-predicts-better-survival-in-patients-with-colorectal-liver-only-metastases-undergoing-liver-resection
#13
Yujie Zhao, Junzhong Lin, Jianhong Peng, Yuxiang Deng, Ruixia Zhao, Qiaoqi Sui, Zhenhai Lu, Desen Wan, Zhizhong Pan
Objective: Hepatitis B virus (HBV) infection has been shown to decrease the risk of liver metastasis in patients with non-metastatic colorectal cancer (CRC). However, the prognostic value of HBV infection in long-term survival of patients with colorectal liver-only metastases (CRLM) after liver resection has not yet been evaluated. This study aims to explore the association between HBV infection and survival in CRLM patients. Methods: A total of 289 CRLM patients undergoing liver resection were recruited at our center from September 1999 to August 2015...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29758333/hepatitis-b-virus-specific-t-cell-responses-after-stopping-nucleos-t-ide-analogue-therapy-in-hbeag-negative-chronic-hepatitis-b
#14
Franziska Rinker, Christine L Zimmer, Christoph Höner Zu Siederdissen, Michael P Manns, Anke R M Kraft, Heiner Wedemeyer, Niklas K Björkström, Markus Cornberg
BACKGROUND AND AIMS: Treatment with nucleos(t)ide analogues (NA) leads to HBV DNA suppression in most patients with chronic hepatitis B (CHB), but HBsAg loss rates are low. Upon NA discontinuation, HBV DNA can return rapidly with ensuing ALT flares and induction of cytokines. Several studies reported higher HBsAg loss rates after stopping therapy, but at present, it is unclear if cell-mediated immune responses are altered after treatment discontinuation. The aim of this study was to characterise T cell responses during the early phase of virological relapse following discontinuation of NA therapy in HBeAg-negative patients...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29757703/hepatitis-b-virus-infection-among-asymptomatic-residents-of-low-income-community-in-ibadan-southwest-nigeria
#15
Adeleye Solomon Bakarey, Oluwaseun Deborah Olaniyan
INTRODUCTION: Hepatitis B Virus (HBV) infection is one of the most infectious diseases worldwide and a major public health concern. In spite of efforts at controlling the scourge globally, HBV continues to thrive in developing countries, such as Nigeria due to ignorance on its mode of transmission and its asymptomatic nature in the populace. Therefore, this community-based study was carried out in Yemetu community in Ibadan, Nigeria to determine the burden of HBV infection among asymptomatic residents of this community...
May 14, 2018: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29757383/considerations-of-antiviral-treatment-to-interrupt-mother-to-child-transmission-of-hepatitis-b-virus-in-china
#16
Fuqiang Cui, Joseph Woodring, Polin Chan, Fujie Xu
Background: Treating high-risk women with antivirals in their third trimester is a promising intervention to further reduce perinatal transmission in neonates born to hepatitis B surface antigen positive [HBsAg(+)] mothers. Methods: We estimated the number of perinatal infections based on coverage and effectiveness of hepatitis B immunization. We compared cost-effectiveness of different approaches to identify high-risk women for antiviral treatment, by region and urban/rural residence...
May 10, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29756347/pre-diagnostic-urinary-15-f-2t-isoprostane-level-and-liver-cancer-risk-results-from-the-shanghai-women-s-and-men-s-health-studies
#17
Xiao Ma, Yu-Ting Tan, Yang Yang, Jing Gao, Hong-Lan Li, Wei Zheng, Qing Lan, Nathaniel Rothman, Xiao-Ou Shu, Yong-Bing Xiang
Oxidative stress has been hypothesized to affect cancer development via various mechanisms, but the evidence from human is limited and inconclusive. 15-F2t -isoprostane (15-F2t -IsoP) is an accurate marker of oxidative stress in humans. Recent studies showed that the evidence of urinary 15-F2t -IsoP level correlating cancer risk is conflicting. We conducted a case-control study nested within two population-based cohort studies. Pre-diagnosis urine samples, collected at cohort enrollment, from 363 incident liver cancer cases and 725 individually matched controls, were used to determine the level of 15-F2t -IsoP by enzyme-linked immunosorbent assay...
May 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29754328/hbsag-negative-and-anti-hbc-positive-in-eosinophilic-granulomatosis-with-polyangiitis-a-retrospective-pilot-study
#18
Sang-Won Lee, Do Young Kim, Sang Hoon Ahn, Yong-Beom Park, Kwang-Hyub Han, Jun Yong Park
We examined whether resolved hepatitis B virus (HBV) infection was associated with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and affected AAV activity at diagnosis and prognosis during the follow-up. We reviewed the electronic medical records of 153 AAV patients, and included 91 hepatitis B surface antigen (HBsAg)-negative patients having results of both antibody to hepatitis B core antigen (anti-HBc) and surface antigen (anti-HBs). We collected clinical and laboratory data, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis and relapse rates during the follow-up...
May 12, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29753083/level-of-hepatitis-b-hb-core-antibody-associates-with-seroclearance-of-hbv-dna-and-hb-surface-antigen-in-hb-e-antigen-seronegative-patients
#19
Hui-Han Hu, Jessica Liu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Yuan Quan, Ning-Shao Xia, Chien-Jen Chen, Pei-Jer Chen, Hwai-I Yang
BACKGROUND & AIMS: Although a low level of hepatitis B surface antigen (HBsAg) is a marker of hepatitis B virus (HBV) seroclearance, additional biomarkers are needed for more accurate prediction. We investigated whether quantification of antibody against HBV core protein (anti-HBc) can identify patients with undetectable levels of HBV DNA and HBsAg seroclearance among those who were HBV e antigen (HBeAg)-seronegative. METHODS: We performed a retrospective analysis of data from a community-based cohort of individuals (30-65 years old) in Taiwan who were HBsAg seropositive, anti-HCV negative, and free of cirrhosis and or liver cancer, recruited from 1991 through 1992, and evaluated every 6-12 months until June 30, 2004...
May 9, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29751272/overcoming-immune-tolerance-in-chronic-hepatitis-b-by-therapeutic-vaccination
#20
REVIEW
Claudia Dembek, Ulrike Protzer, Michael Roggendorf
The currently used nucleoside analogs (i.e. entecavir and tenofovir) with high barrier-to-resistance efficiently suppress viral replication, limit inflammation and reduce the sequelae of chronic hepatitis B, but cannot cure the disease and thus have to be applied long-term. Therapeutic vaccination as an approach to cure chronic hepatitis B has shown promising pre-clinical results, nevertheless the proof of its efficacy in clinical trials is still missing. This may be partially due to suboptimal vaccine design...
May 8, 2018: Current Opinion in Virology
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