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https://www.readbyqxmd.com/read/27876036/diabetes-screening-intervals-based-on-risk-stratification
#1
Sachiko Ohde, Emily McFadden, Gautam A Deshpande, Hiroshi Yokomichi, Osamu Takahashi, Tsuguya Fukui, Rafael Perera, Zentaro Yamagata
BACKGROUND: Guidelines for frequency of Type 2 diabetes mellitus (DM) screening remain unclear, with proposed screening intervals typically based on expert opinion. This study aims to demonstrate that HbA1c screening intervals may differ substantially when considering individual risk for diabetes. METHODS: This was a multi-institutional retrospective open cohort study. Data were collected between April 1999 to March 2014 from one urban and one rural cohort in Japan...
November 22, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27811997/effects-of-chronic-noise-on-glucose-metabolism-and-gut-microbiota-host-inflammatory-homeostasis-in-rats
#2
Bo Cui, Zhihui Gai, Xiaojun She, Rui Wang, Zhuge Xi
Chronic noise exposure has been implicated in increased risk of diabetes. However, there is limited experimental evidence of the mechanisms linking chronic noise stress and glucose metabolism. We addressed this in the present study by examining glucose metabolism, immune response, and changes in gut microbiota/host inflammatory homeostasis in rats exposed to noise for 30 consecutive days. Chronic noise exposure increased blood glucose and corticosterone levels for at least 14 days after cessation of noise. Stressed rats also exhibited elevated levels of glycogen and triglyceride in the liver and impaired hepatic insulin production via insulin-induced insulin receptor/insulin receptor substrate 1/glycogen synthase kinase 3β signalling, which persisted for 3-14 days after cessation of noise exposure...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27763533/non-enzymatic-glucose-sensing-using-carbon-quantum-dots-decorated-with-copper-oxide-nanoparticles
#3
Houcem Maaoui, Florina Teodoresu, Qian Wang, Guo-Hui Pan, Ahmed Addad, Radhouane Chtourou, Sabine Szunerits, Rabah Boukherroub
Perturbations in glucose homeostasis is critical for human health, as hyperglycemia (defining diabetes) leads to premature death caused by macrovascular and microvascular complications. However, the simple and accurate detection of glucose in the blood at low cost remains a challenging task, although it is of great importance for the diagnosis and therapy of diabetic patients. In this work, carbon quantum dots decorated with copper oxide nanostructures (CQDs/Cu₂O) are prepared by a simple hydrothermal approach, and their potential for electrochemical non-enzymatic glucose sensing is evaluated...
October 18, 2016: Sensors
https://www.readbyqxmd.com/read/27761267/the-association-between-long-working-hours-and-hearing-impairment-in-noise-unexposed-workers-data-from-the-5th-korea-national-health-and-nutrition-examination-survey-knhanes-2010-2012
#4
Jung-Woo Park, Jin-Soo Park, Seyoung Kim, Minkyu Park, Hyunrim Choi, Sinye Lim
BACKGROUND: This study is aimed at finding out the relationship between long working hours, one of major job stress elements, and hearing impairment in unexposed workers to occupational and environmental noise. METHODS: This study was performed on 1628 regular, full-time wage workers between the age of 25-64 who indicated in the survey of having no experience of exposure to noise, normal otoscopic findings, and not suffering from diabetes based on the data from the fifth Korea National Health and Nutrition Examination Survey (KNHANES 2010-2012)...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27756410/stiff-person-syndrome-in-south-asia
#5
Thashi Chang, Bethan Lang, Angela Vincent
BACKGROUND: Stiff person syndrome is a highly disabling, progressive autoimmune disorder of the central nervous system characterized by muscle rigidity and spasms. Stiff person syndrome is rare, but is believed to be under diagnosed with only 14 cases been reported among a 1.7 billion population in South Asia. We report the first authenticated case from Sri Lanka. CASE PRESENTATION: A 55-year-old Sri Lankan female presented with difficulty in walking and recurrent falls due to progressive muscular rigidity in her lower limbs and trunk with superimposed muscle spasms that occurred in response to unexpected noise, startle or emotional upset...
October 18, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27729094/identification-of-donor-origin-and-condition-of-transplanted-islets-in-situ-in-the-liver-of-a-type-1-diabetic-recipient
#6
Cornelis R van der Torren, Jessica S Suwandi, DaHae Lee, Ernst-Jan T van 't Wout, Gaby Duinkerken, Godelieve Swings, Arend Mulder, Frans H J Claas, Zhidong Ling, Pieter Gillard, Bart Keymeulen, Peter In 't Veld, Bart O Roep
Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surrogate immune markers in peripheral blood. We investigated donor origin and infiltration of islets transplanted in the liver of a T1D patient who died of hemorrhagic stroke four months after successful transplantation with two intraportal islet grafts combining six donors...
October 10, 2016: Cell Transplantation
https://www.readbyqxmd.com/read/27714563/performance-analysis-of-fuzzy-pid-controller-for-blood-glucose-regulation-in-type-1-diabetic-patients
#7
Jyoti Yadav, Asha Rani, Vijander Singh
This paper presents Fuzzy-PID (FPID) control scheme for a blood glucose control of type 1 diabetic subjects. A new metaheuristic Cuckoo Search Algorithm (CSA) is utilized to optimize the gains of FPID controller. CSA provides fast convergence and is capable of handling global optimization of continuous nonlinear systems. The proposed controller is an amalgamation of fuzzy logic and optimization which may provide an efficient solution for complex problems like blood glucose control. The task is to maintain normal glucose levels in the shortest possible time with minimum insulin dose...
December 2016: Journal of Medical Systems
https://www.readbyqxmd.com/read/27709075/automated-registration-and-enhanced-processing-of-clinical-optical-coherence-tomography-angiography
#8
Acner Camino, Miao Zhang, Changlei Dongye, Alex D Pechauer, Thomas S Hwang, Steven T Bailey, Brandon Lujan, David J Wilson, David Huang, Yali Jia
BACKGROUND: Motion artifacts degrade the quality of optical coherence tomography angiography (OCTA). Orthogonal registration can eliminate the majority of these artifacts, but some artifacts persist in most clinical images. We evaluate an automated registration algorithm with selective merging and filtering to remove remaining artifacts and improve the quality of images. METHODS: A 70 kHz commercial spectral domain OCT was used to obtain 3 mm × 3 mm OCTA in 10 healthy, 5 age-related macular degeneration (AMD), and 31 diabetic retinopathy (DR) participants...
August 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27681078/decreases-in-gap-junction-coupling-recovers-ca2-and-insulin-secretion-in-neonatal-diabetes-mellitus-dependent-on-beta-cell-heterogeneity-and-noise
#9
Aleena M Notary, Matthew J Westacott, Thomas H Hraha, Marina Pozzoli, Richard K P Benninger
Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile secretory response at elevated glucose and suppressing insulin secretion at basal glucose. Previously, we demonstrated that a critical number of inexcitable cells can rapidly suppress the overall islet response, as a result of gap junction coupling. This was demonstrated in a murine model of Neonatal Diabetes Mellitus (NDM) involving expression of ATP-insensitive KATP channels, and by a multi-cellular computational model of islet electrical activity...
September 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27635151/improved-ceemdan-and-pso-svr-modeling-for-near-infrared-noninvasive-glucose-detection
#10
Xiaoli Li, Chengwei Li
Diabetes is a serious threat to human health. Thus, research on noninvasive blood glucose detection has become crucial locally and abroad. Near-infrared transmission spectroscopy has important applications in noninvasive glucose detection. Extracting useful information and selecting appropriate modeling methods can improve the robustness and accuracy of models for predicting blood glucose concentrations. Therefore, an improved signal reconstruction and calibration modeling method is proposed in this study. On the basis of improved complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and correlative coefficient, the sensitive intrinsic mode functions are selected to reconstruct spectroscopy signals for developing the calibration model using the support vector regression (SVR) method...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27613658/an-adaptive-nonlinear-basal-bolus-calculator-for-patients-with-type-1-diabetes
#11
Dimitri Boiroux, Tinna Björk Aradóttir, Kirsten Nørgaard, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen
BACKGROUND: Bolus calculators help patients with type 1 diabetes to mitigate the effect of meals on their blood glucose by administering a large amount of insulin at mealtime. Intraindividual changes in patients physiology and nonlinearity in insulin-glucose dynamics pose a challenge to the accuracy of such calculators. METHOD: We propose a method based on a continuous-discrete unscented Kalman filter to continuously track the postprandial glucose dynamics and the insulin sensitivity...
September 8, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27586488/a-fully-automatic-nerve-segmentation-and-morphometric-parameter-quantification-system-for-early-diagnosis-of-diabetic-neuropathy-in-corneal-images
#12
Shumoos Al-Fahdawi, Rami Qahwaji, Alaa S Al-Waisy, Stanley Ipson, Rayaz A Malik, Arun Brahma, Xin Chen
Diabetic Peripheral Neuropathy (DPN) is one of the most common types of diabetes that can affect the cornea. An accurate analysis of the nerve structures can assist the early diagnosis of this disease. This paper proposes a robust, fast and fully automatic nerve segmentation and morphometric parameter quantification system for corneal confocal microscope images. The segmentation part consists of three main steps. First, a preprocessing step is applied to enhance the visibility of the nerves and remove noise using anisotropic diffusion filtering, specifically a Coherence filter followed by Gaussian filtering...
October 2016: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27572140/in-vivo-retinal-and-choroidal-hypoxia-imaging-using-a-novel-activatable-hypoxia-selective-near-infrared-fluorescent-probe
#13
Shinichi Fukuda, Kensuke Okuda, Genichiro Kishino, Sujin Hoshi, Itsuki Kawano, Masahiro Fukuda, Toshiharu Yamashita, Simone Beheregaray, Masumi Nagano, Osamu Ohneda, Hideko Nagasawa, Tetsuro Oshika
PURPOSE: Retinal hypoxia plays a crucial role in ocular neovascular diseases, such as diabetic retinopathy, retinopathy of prematurity, and retinal vascular occlusion. Fluorescein angiography is useful for identifying the hypoxia extent by detecting non-perfusion areas or neovascularization, but its ability to detect early stages of hypoxia is limited. Recently, in vivo fluorescent probes for detecting hypoxia have been developed; however, these have not been extensively applied in ophthalmology...
December 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27570129/assessing-the-content-of-youtube-videos-in-educating-patients-regarding-common-imaging-examinations
#14
Andrew B Rosenkrantz, Eugene Won, Ankur M Doshi
PURPOSE: To assess the content of currently available YouTube videos seeking to educate patients regarding commonly performed imaging examinations. METHODS: After initial testing of possible search terms, the first two pages of YouTube search results for "CT scan," "MRI," "ultrasound patient," "PET scan," and "mammogram" were reviewed to identify educational patient videos created by health organizations. Sixty-three included videos were viewed and assessed for a range of features...
August 25, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27566342/titania-nanotubes-decorated-with-gold-nanoparticles-for-electrochemiluminescent-biosensing-of-glycosylated-hemoglobin
#15
Qun Zhao, Shan Tang, Chen Fang, Yi-Feng Tu
A glycated hemoglobin (HbA1c) biosensor with high performance has been constructed in this work. Here the fructosyl amino acid oxidase was immobilized onto a pre-functionalized indium tin oxide glass with titania nanotubes decorated with gold nanoparticles. The property of nanocomposite was characterized by transmission electromicroscopy, scanning electron microscopy, electrochemistry and spectroscopy. Under the optimum conditions, fructosyl valine was detected by this biosensor. It exhibited a linear detection range from 4...
September 14, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27546348/speech-perception-performance-in-subjects-with-type-i-diabetes-mellitus-in-noise
#16
Bárbara Cristiane Sordi Silva, Erika Barioni Mantello, Maria Cristina Foss Freitas, Milton César Foss, Myriam de Lima Isaac, Adriana Ribeiro Tavares Anastasio
INTRODUCTION: Diabetes mellitus (DM) is a chronic metabolic disorder of various origins that occurs when the pancreas fails to produce insulin in sufficient quantities or when the organism fails to respond to this hormone in an efficient manner. OBJECTIVE: To evaluate the speech recognition in subjects with type I diabetes mellitus (DMI) in quiet and in competitive noise. METHODS: It was a descriptive, observational and cross-section study...
August 9, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27501653/anesthetic-considerations-of-stiff-person-syndrome-a-case-report
#17
Kristi Hylan, An-Duyen Nguyen Vu, Katherine Stammen
Stiff-person syndrome (SPS) is a neurologic disorder characterized by painful involuntary episodes of severe muscle rigidity affecting the axial muscles and extremities. Although the etiology of SPS is unknown, it is suspected to involve the synthesis of γ-aminobutyric acid (GABA). Symptoms of SPS are precipitated by sudden unexpected movements, noises, and stress. Additionally, SPS has been linked with various autoimmune disorders, including diabetes mellitus, thyroid disease, pernicious anemia, and certain cancers...
June 2016: AANA Journal
https://www.readbyqxmd.com/read/27460892/environmental-stressors-and-cardio-metabolic-disease-part-i-epidemiologic-evidence-supporting-a-role-for-noise-and-air-pollution-and-effects-of-mitigation-strategies
#18
Thomas Münzel, Mette Sørensen, Tommaso Gori, Frank P Schmidt, Xiaoquan Rao, Jeffrey Brook, Lung Chi Chen, Robert D Brook, Sanjay Rajagopalan
Traffic noise and air pollution together represent the two most important environmental risk factors in urbanized societies. The first of this two-part review discusses the epidemiologic evidence in support of the existence of an association between these risk factors with cardiovascular and metabolic disease. While independent effects of these risk factors have now clearly been shown, recent studies also suggest that the two exposures may interact with each other and with traditional risk factors such as hypertension and type 2 diabetes...
July 26, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27460891/environmental-stressors-and-cardio-metabolic-disease-part-ii-mechanistic-insights
#19
Thomas Münzel, Mette Sørensen, Tommaso Gori, Frank P Schmidt, Xiaoquan Rao, Frank R Brook, Lung Chi Chen, Robert D Brook, Sanjay Rajagopalan
Environmental factors can act as facilitators of chronic non-communicable diseases. Ambient noise and air pollution collectively outrank all other environmental risk factors in importance, contributing to over 75% of the disease and disability burden associated with known environmental risk factors. In the first part of this review, we discussed the global burden and epidemiologic evidence supporting the importance of these novel risk factors as facilitators of cardiometabolic disease. In this part, we will discuss pathophysiological mechanisms responsible for noise and air pollution-mediated effects...
July 26, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27451314/a-new-eeg-synchronization-strength-analysis-method-s-estimator-based-normalized-weighted-permutation-mutual-information
#20
Dong Cui, Weiting Pu, Jing Liu, Zhijie Bian, Qiuli Li, Lei Wang, Guanghua Gu
Synchronization is an important mechanism for understanding information processing in normal or abnormal brains. In this paper, we propose a new method called normalized weighted-permutation mutual information (NWPMI) for double variable signal synchronization analysis and combine NWPMI with S-estimator measure to generate a new method named S-estimator based normalized weighted-permutation mutual information (SNWPMI) for analyzing multi-channel electroencephalographic (EEG) synchronization strength. The performances including the effects of time delay, embedding dimension, coupling coefficients, signal to noise ratios (SNRs) and data length of the NWPMI are evaluated by using Coupled Henon mapping model...
October 2016: Neural Networks: the Official Journal of the International Neural Network Society
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