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https://www.readbyqxmd.com/read/28721941/blood-glucose-concentration-control-for-type-1-diabetic-patients-a-non-linear-suboptimal-approach
#1
Yazdan Batmani
In this study, a closed-loop treatment strategy is proposed for the control of blood glucose levels in type 1 diabetic patients. Toward this end, a non-linear technique for designing suboptimal tracking controllers, called the state-dependent Riccati equation tracker, is used based on a mathematical model of the glucose-insulin regulatory system. Since two state variables of the utilised model are not available to the controller, a non-linear filter is also designed to estimate these variables using the measured blood glucose concentration...
August 2017: IET Systems Biology
https://www.readbyqxmd.com/read/28720778/visualization-of-kidney-fibrosis-in-diabetic-nephropathy-by-long-diffusion-tensor-imaging-mri-with-spin-echo-sequence
#2
Jun-Ya Kaimori, Yoshitaka Isaka, Masaki Hatanaka, Satoko Yamamoto, Naotsugu Ichimaru, Akihiko Fujikawa, Hiroshi Shibata, Akira Fujimori, Sosuke Miyoshi, Takashi Yokawa, Kagayaki Kuroda, Toshiki Moriyama, Hiromi Rakugi, Shiro Takahara
Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step to identify possible MRI methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI) MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). The signal-to-noise ratio in DTI MRI was enhanced using a spin-echo sequence, and a special kidney attachment was developed for long-term stabilization...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720223/absorbance-detector-for-high-performance-liquid-chromatography-based-on-a-deep-uv-light-emitting-diode-at-235nm
#3
João Flavio da Silveira Petruci, Michael G Liebetanz, Arnaldo Alves Cardoso, Peter C Hauser
In this communication, we describe a flow-through optical absorption detector for HPLC using for the first time a deep-UV light-emitting diode with an emission band at 235nm as light source. The detector is also comprised of a UV-sensitive photodiode positioned to enable measurement of radiation through a flow-through cuvette with round aperture of 1mm diameter and optical path length of 10mm, and a second one positioned as reference photodiode; a beam splitter and a power supply. The absorbance was measured and related to the analyte concentration by emulating the Lambert-Beer law with a log-ratio amplifier circuitry...
July 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28720102/environmental-lifestyle-factors-in-the-pathogenesis-and-prevention-of-type-2-diabetes
#4
REVIEW
Hubert Kolb, Stephan Martin
BACKGROUND: Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed to account for the rapid global increase in type 2 diabetes prevalence and incidence in recent decades. DISCUSSION: In this review, we present a comprehensive overview of factors contributing to diabetes risk, including aspects of diet quality and quantity, little physical activity, increased monitor viewing time or sitting in general, exposure to noise or fine dust, short or disturbed sleep, smoking, stress and depression, and a low socioeconomic status...
July 19, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28707484/autoregressive-modeling-of-drift-and-random-error-to-characterize-a-continuous-intravascular-glucose-monitoring-sensor
#5
Tony Zhou, Jennifer L Dickson, J Geoffrey Chase
BACKGROUND: Continuous glucose monitoring (CGM) devices have been effective in managing diabetes and offer potential benefits for use in the intensive care unit (ICU). Use of CGM devices in the ICU has been limited, primarily due to the higher point accuracy errors over currently used traditional intermittent blood glucose (BG) measures. General models of CGM errors, including drift and random errors, are lacking, but would enable better design of protocols to utilize these devices. This article presents an autoregressive (AR) based modeling method that separately characterizes the drift and random noise of the GlySure CGM sensor (GlySure Limited, Oxfordshire, UK)...
July 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28697826/-risk-factors-for-congenital-heart-disease-in-chinese-neonates-a-meta-analysis
#6
Yi Liu, Bei Zhu, Lin Zhuo, Ming-Yu He, Yang Xu, Tong-Tong Wang, Qing-Qing Cai, Bin Hu, Ji-Cheng Xu, Wen-Hui Zhang
OBJECTIVE: To investigate the major risk factors for congenital heart disease (CHD) in Chinese neonates and to provide a reference for the prevention of CHD. METHODS: A literature search was performed to collect the case-control studies on the risk factors for CHD in Chinese neonates published in 2001-2016. The relevant data were extracted accordingly. The quality of included studies was assessed by Newcastle-Ottawa Scale. Sensitivity analysis was conducted using different models to analyze the same data...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28685099/integrative-analysis-of-pathway-deregulation-in-obesity
#7
Francesc Font-Clos, Stefano Zapperi, Caterina A M La Porta
Obesity is a pandemic disease, linked to the onset of type 2 diabetes and cancer. Transcriptomic data provides a picture of the alterations in regulatory and metabolic activities associated with obesity, but its interpretation is typically blurred by noise. Here, we solve this problem by collecting publicly available transcriptomic data from adipocytes and removing batch effects using singular value decomposition. In this way we obtain a gene expression signature of 38 genes associated to obesity and identify the main pathways involved...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28678080/noise-history-and-auditory-function-in-young-adults-with-and-without-type-1-diabetes-mellitus
#8
Christopher Spankovich, Colleen G Le Prell, Edward Lobarinas, Linda J Hood
OBJECTIVES: The purpose of this study was to examine the relationship between noise exposure history, type 1 diabetes mellitus (DM), and suprathreshold measures of auditory function. DESIGN: A cross-sectional study was conducted; 20 normal-hearing participants without type 1 DM were matched on age and sex to 20 normal-hearing participants with type 1 DM (n=40). Participants, all having normal audiometric thresholds, completed noise history questionnaires and a battery of auditory physiological tests including transient evoked otoacoustic emissions, distortion product otoacoustic emissions, and auditory brainstem responses (ABR) at 80 dB nHL and at 2 different stimulus rates in both ears...
July 1, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28660337/differential-mobility-spectrometry-tandem-mass-spectrometry-with-multiple-ion-monitoring-for-the-bioanalysis-of-liraglutide
#9
Xiangjun Meng, Haitong Xu, Zhi Zhang, John Paul Fawcett, Junru Li, Yan Yang, Jingkai Gu
Liraglutide is a glucagon-like peptide-1 analog for the treatment of type 2 diabetes. Major interference in plasma of human and animals and low fragment signal in tandem mass spectrometry are the main difficulties encountered in the bioanalysis of liraglutide. In this study, by combining differential mobility spectrometry (DMS) with multiple ion monitoring detection (MIM), a liquid chromatography differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring detection (LC-DMS-MIM) method was developed for the quantitation of liraglutide in dog plasma...
June 28, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28659725/system-level-meta-analysis-of-microarray-datasets-for-elucidation-of-diabetes-mellitus-pathobiology
#10
Aditya Saxena, Kumar Sachin, Ashok Kumar Bhatia
BACKGROUND: Type 2 diabetes (T2D) is a common multi-factorial disease that is primarily ac-counted to ineffective insulin action in lowering blood glucose level and later escalates to impaired insu-lin secretion by pancreatic β cells. Deregulation in insulin signaling to its target organs is attributed to this disease phenotype. Various genome-wide microarray studies from multiple insulin responsive tis-sues have been conducted in past but due to inherent noise in microarray data and heterogeneity in dis-ease etiology; reproduction of prioritized pathways/genes is very low across various studies...
June 2017: Current Genomics
https://www.readbyqxmd.com/read/28604634/modeling-the-error-of-the-medtronic-paradigm-veo-enlite-glucose-sensor
#11
Lyvia Biagi, Charrise M Ramkissoon, Andrea Facchinetti, Yenny Leal, Josep Vehi
Continuous glucose monitors (CGMs) are prone to inaccuracy due to time lags, sensor drift, calibration errors, and measurement noise. The aim of this study is to derive the model of the error of the second generation Medtronic Paradigm Veo Enlite (ENL) sensor and compare it with the Dexcom SEVEN PLUS (7P), G4 PLATINUM (G4P), and advanced G4 for Artificial Pancreas studies (G4AP) systems. An enhanced methodology to a previously employed technique was utilized to dissect the sensor error into several components...
June 12, 2017: Sensors
https://www.readbyqxmd.com/read/28584317/exposure-to-self-reported-occupational-noise-and-diabetes-a-cross-sectional-relationship-in-7th-european-social-survey-ess7-2014
#12
Angel Mario Dzhambov
OBJECTIVES: Almost nothing is known about the effect of occupational noise on diabetes, and this is particularly relevant given the wide spread of both noise exposure and diabetes. This study has aimed to determine whether occupational noise exposure is associated with higher risk of diabetes in Europe. MATERIAL AND METHODS: This study is based on 7th European Social Survey (ESS7, 2014) - a multi-country population-based questionnaire survey, which covered 28 221 Europeans aged ≥ 15 years old...
April 14, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28560245/assistive-lesion-emphasis-system-an-assistive-system-for-fundus-image-readers
#13
Samrudhdhi B Rangrej, Jayanthi Sivaswamy
Computer-assisted diagnostic (CAD) tools are of interest as they enable efficient decision-making in clinics and the screening of diseases. The traditional approach to CAD algorithm design focuses on the automated detection of abnormalities independent of the end-user, who can be an image reader or an expert. We propose a reader-centric system design wherein a reader's attention is drawn to abnormal regions in a least-obtrusive yet effective manner, using saliency-based emphasis of abnormalities and without altering the appearance of the background tissues...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28553744/relationship-between-dietary-quality-tinnitus-and-hearing-level-data-from-the-national-health-and-nutrition-examination-survey-1999-2002
#14
Christopher Spankovich, Charles Bishop, Mary Frances Johnson, Alex Elkins, Dan Su, Edward Lobarinas, Colleen G Le Prell
OBJECTIVE: To examine the relationship between the healthy eating index (HEI), a measure of dietary quality based on United States Department of Agriculture recommendations and report of tinnitus. DESIGN: This cross-sectional analysis was based on HEI data and report of tinnitus. STUDY SAMPLE: Data for adults between 20 and 69 years of age were drawn from the National Health and Nutrition Examination Survey (NHANES), 1999-2002. The NHANES is a programme of studies, to assess the health and nutritional status of adults and children in the United States...
May 27, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28521190/simultaneous-determination-of-bisphenol-a-and-estrogens-in-hair-samples-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#15
Chaelin Lee, Chong Hyeak Kim, Sunghwan Kim, Sung-Hee Cho
Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple...
May 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28470000/input-estimation-for-extended-release-formulations-exemplified-with-exenatide
#16
Magnus Trägårdh, Michael J Chappell, Johan E Palm, Neil D Evans, David L I Janzén, Peter Gennemark
Estimating the in vivo absorption profile of a drug is essential when developing extended-release medications. Such estimates can be obtained by measuring plasma concentrations over time and inferring the absorption from a model of the drug's pharmacokinetics. Of particular interest is to predict the bioavailability-the fraction of the drug that is absorbed and enters the systemic circulation. This paper presents a framework for addressing this class of estimation problems and gives advice on the choice of method...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28410120/snp_tata_comparator-genomewide-landmarks-for-preventive-personalized-medicine
#17
REVIEW
Mikhail Ponomarenko, Dmitry Rasskazov, Irina Chadaeva, Ekaterina Sharypova, Petr Ponomarenko, Olga Arkova, Elena Kashina, Nikita Ivanisenko, Dmitry Zhechev, Ludmila Savinkova, Nikolay Kolchanov
Year after year, conditions, quality, and duration of human lives have been improving due to the progress of science, technology, education, and medicine, which however has a downside. Owing to improvement in children's nutrition, developmental acceleration occurs that imbalances a child's system. Because of virtual worlds of the Internet, social experience of teenagers expands and clashes with puberty of adolescents. Due to the comfort of cities, urbanization emerges and causes stress to adults because of artificial light, noise, pollution, violations of personal space, and family disruption...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28403870/noise-sensitivity-rather-than-noise-level-predicts-the-non-auditory-effects-of-noise-in-community-samples-a-population-based-survey
#18
Jangho Park, Seockhoon Chung, Jiho Lee, Joo Hyun Sung, Seung Woo Cho, Chang Sun Sim
BACKGROUND: Excessive noise affects human health and interferes with daily activities. Although environmental noise may not directly cause mental illness, it may accelerate and intensify the development of latent mental disorders. Noise sensitivity (NS) is considered a moderator of non-auditory noise effects. In the present study, we aimed to assess whether NS is associated with non-auditory effects. METHODS: We recruited a community sample of 1836 residents residing in Ulsan and Seoul, South Korea...
April 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28384126/an-automated-method-for-accurate-vessel-segmentation
#19
Xin Yang, Chaoyue Liu, Hung Le Minh, Zhiwei Wang, Aichi Chien, Kwang-Ting Tim Cheng
Vessel segmentation is a critical task for various medical applications, such as diagnosis assistance of diabetic retinopathy, quantification of cerebral aneurysm's growth, and guiding surgery in neurosurgical procedures. Despite technology advances in image segmentation, existing methods still suffer from low accuracy for vessel segmentation in the two challenging while common scenarios in clinical usage: (1) regions with a low signal-to-noise-ratio (SNR), and (2) at vessel boundaries disturbed by adjacent non-vessel pixels...
April 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28346907/long-term-associations-of-modeled-and-self-reported-measures-of-exposure-to-air-pollution-and-noise-at-residence-on-prevalent-hypertension-and-blood-pressure
#20
Anitha Pitchika, Regina Hampel, Kathrin Wolf, Ute Kraus, Josef Cyrys, Wolfgang Babisch, Annette Peters, Alexandra Schneider
Air pollution, traffic noise and noise annoyance are suggested to be associated with hypertension and blood pressure (BP); however, the evidence remains inconsistent. Our study examined the long-term associations of modeled and self-reported measures of air pollution and traffic noise on prevalent hypertension and BP. We analyzed cross-sectional data from 2552 participants aged 31-72years from the KORA F4 (2006-2008) study conducted in the region of Augsburg, Germany. Land-use regression models were used to estimate residential long-term exposure to particulate matter <2...
March 24, 2017: Science of the Total Environment
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