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https://www.readbyqxmd.com/read/28720102/environmental-lifestyle-factors-in-the-pathogenesis-and-prevention-of-type-2-diabetes
#1
REVIEW
Hubert Kolb, Stephan Martin
BACKGROUND: Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed to account for the rapid global increase in type 2 diabetes prevalence and incidence in recent decades. DISCUSSION: In this review, we present a comprehensive overview of factors contributing to diabetes risk, including aspects of diet quality and quantity, little physical activity, increased monitor viewing time or sitting in general, exposure to noise or fine dust, short or disturbed sleep, smoking, stress and depression, and a low socioeconomic status...
July 19, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28626847/injury-intense-dust-exposure-and-chronic-disease-among-survivors-of-the-world-trade-center-terrorist-attacks-of-september-11-2001
#2
Howard E Alper, Shengchao Yu, Steven D Stellman, Robert M Brackbill
BACKGROUND: The World Trade Center attack of September 11, 2001 in New York City (9/11) exposed thousands of people to intense concentrations of hazardous materials that have resulted in reports of increased levels of asthma, heart disease, diabetes, and other chronic diseases along with psychological illnesses such as post-traumatic stress disorder (PTSD). Few studies have discriminated between health consequences of immediate (short-term or acute) intense exposures versus chronic residential or workplace exposures...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28565941/insulin-replacement-limits-progression-of-diabetic-cardiomyopathy-in-the-low-dose-streptozotocin-induced-diabetic-rat
#3
Mitchel Tate, Minh Deo, Anh H Cao, Sally G Hood, Karina Huynh, Helen Kiriazis, Xiao-Jun Du, Tracey L Julius, Gemma A Figtree, Gregory J Dusting, David M Kaye, Rebecca H Ritchie
Diabetic cardiomyopathy is a major contributor to the increasing burden of heart failure globally. Effective therapies remain elusive, in part due to the incomplete understanding of the mechanisms underlying diabetes-induced myocardial injury. The objective of this study was to assess the direct impact of insulin replacement on left ventricle structure and function in a rat model of diabetes. Male Sprague-Dawley rats were administered streptozotocin (55 mg/kg i.v.) or citrate vehicle and were followed for 8 weeks...
May 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28504650/neutrophil-derived-s100-calcium-binding-proteins-a8-a9-promote-reticulated-thrombocytosis-and-atherogenesis-in-diabetes
#4
Michael J Kraakman, Man Ks Lee, Annas Al-Sharea, Dragana Dragoljevic, Tessa J Barrett, Emilie Montenont, Debapriya Basu, Sarah Heywood, Helene L Kammoun, Michelle Flynn, Alexandra Whillas, Nordin Mj Hanssen, Mark A Febbraio, Erik Westein, Edward A Fisher, Jaye Chin-Dusting, Mark E Cooper, Jeffrey S Berger, Ira J Goldberg, Prabhakara R Nagareddy, Andrew J Murphy
Platelets play a critical role in atherogenesis and thrombosis-mediated myocardial ischemia, processes that are accelerated in diabetes. Whether hyperglycemia promotes platelet production and whether enhanced platelet production contributes to enhanced atherothrombosis remains unknown. Here we found that in response to hyperglycemia, neutrophil-derived S100 calcium-binding proteins A8/A9 (S100A8/A9) interact with the receptor for advanced glycation end products (RAGE) on hepatic Kupffer cells, resulting in increased production of IL-6, a pleiotropic cytokine that is implicated in inflammatory thrombocytosis...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28161068/distribution-and-potential-significance-of-intravillous-and-intrafibrinous-particulate-microcalcification
#5
Jennifer Zeng, Alan Marcus, Tatiana Buhtoiarova, Khushbakhat Mittal
Radiologic studies indicate that placental calcifications seen at 28-32 weeks' gestation are associated with adverse fetal outcome. One type of placental calcification is typically located at the basement membrane of chorionic villi. It has a fine particulate appearance and can only be seen microscopically. We have designated these calcifications as Intravillous and Intrafibrinous Particulate MicroCalcification (IPMC). In this study we examined the distribution and potential significance of IPMC. Placentas from 14 groups of fetal and maternal outcomes are examined histologically for IPMC...
February 2017: Placenta
https://www.readbyqxmd.com/read/28132907/gene-therapy-for-diabetic-retinopathy-are-we-ready-to-make-the-leap-from-bench-to-bedside
#6
REVIEW
Jiang-Hui Wang, Damien Ling, Leilei Tu, Peter van Wijngaarden, Gregory J Dusting, Guei-Sheung Liu
Diabetic retinopathy (DR), a chronic and progressive complication of diabetes mellitus, is a sight-threatening disease characterized in the early stages by neuronal and vascular dysfunction in the retina, and later by neovascularization that further damages vision. A major contributor to the pathology is excess production of vascular endothelial growth factor (VEGF), a growth factor that induces formation of new blood vessels and increases permeability of existing vessels. Despite the recent availability of effective treatments for the disease, including laser photocoagulation and therapeutic VEGF antibodies, DR remains a significant cause of vision loss worldwide...
January 27, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28054921/evaluation-of-the-effects-of-air-pollutants-on-diabetic-wounds
#7
Young Suk Choi, Il-Hoon Sung, Ji Yun Lim, A Hyun Kyun, Eui Dong Yeo, Sun Geun Lee, Young Koo Lee
BACKGROUND: Although air pollution containing fine dust particles is gaining attention worldwide, little is known about the effects of such pollutants on diabetic wounds. Air pollutants from diesel exhaust particles (DEPs) cause inflammation, resulting in an increased expression of pro-inflammatory cytokines and chemo- kines, which attract monocytes and T cells to the sites of inflamma- tion. The authors evaluated the effects of air pollutants on diabetic wounds. MATERIALS AND METHODS: Fibroblast cells were derived from streptozotocin-induced diabetic rats...
March 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/27976661/an-approach-to-interpreting-restrictive-spirometric-pattern-results-in-occupational-settings
#8
Federica Tafuro, Massimo Corradi
OBJECTIVES: The aim of this review is to provide an updated overview of definition, epidemiology, diagnostic algorithm and occupational exposures related to abnormal restrictive spirometrical pattern (RSP) in order to improve the correct interpretation of spirometry test results by occupational healthcare providers. METHODS: A review of the scientific English literature of the last 25 years was carried out with MEDLINE and related keywords [(restricti* AND spirometr*) AND occupational]...
December 13, 2016: La Medicina del Lavoro
https://www.readbyqxmd.com/read/27968831/mortality-as-a-function-of-dust-haze-in-china-a-multi-city-time-series-study
#9
Jun Yang, Maigeng Zhou, Peng Yin, Mengmeng Li, Chun-Quan Ou, Shaohua Gu, Qiyong Liu
BACKGROUND: In recent years, hazardous dust-hazehas become one of the most catastrophic weather events in China. Reliable estimation of the burden of dust-haze on health has implications for implementation of mitigation measures. We did a time-series study to examine the health effects of dust-haze in China. METHODS: A dust-haze day was defined ashaving daily visibility of less than 10 km, no rainfall, and relative humidity of less than 80%. A two-stage analysis was used to assess the effect of dust-haze on city-specific, cause-specific, sex-specific, and age-specific mortality in ten Chinese provincial capitals...
October 2016: Lancet
https://www.readbyqxmd.com/read/27803762/role-of-antioxidants-and-natural-products-in-inflammation
#10
REVIEW
Palanisamy Arulselvan, Masoumeh Tangestani Fard, Woan Sean Tan, Sivapragasam Gothai, Sharida Fakurazi, Mohd Esa Norhaizan, S Suresh Kumar
Inflammation is a comprehensive array of physiological response to a foreign organism, including human pathogens, dust particles, and viruses. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. Recent investigations have clarified that inflammation is a major factor for the progression of various chronic diseases/disorders, including diabetes, cancer, cardiovascular diseases, eye disorders, arthritis, obesity, autoimmune diseases, and inflammatory bowel disease...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27708206/short-term-exposure-to-ambient-fine-particulate-matter-pm2-5-and-pm10-and-the-risk-of-heart-rhythm-abnormalities-and-stroke
#11
REVIEW
Małgorzata Kowalska, Krzysztof Kocot
Results of epidemiological studies suggest a significant impact of ambient particulate matter air pollution (PM10 and PM2,5) on the health of the population. Increased level of these pollutants is connected with increased rate of daily mortality and hospitalizations due to cardiovascular diseases. Among analyzed health effects, heart arrhythmias and stroke are mentioned most frequently. The aim of the study was to present the current knowledge of potential influence of the exposure to fine particulate matter on the presence of arrhythmias and strokes...
September 28, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27433467/human-and-environmental-dangers-posed-by-ongoing-global-tropospheric-aerosolized-particulates-for-weather-modification
#12
J Marvin Herndon
BACKGROUND: U.S. military perception of nuclear warfare led to countless unethical nuclear experiments performed on unsuspecting individuals without their informed consent. As evidenced here, subsequent perception of weather warfare has led to exposing millions of unsuspecting individuals to toxic coal fly ash with no public disclosure, no informed consent, and no health warnings. METHODS: Three methods were used: (1) comparison of eight elements analyzed in rainwater samples, thought to have leached from aerosolized coal fly ash, with corresponding coal fly ash laboratory leachate; (2) comparison of 14 elements analyzed in air filter dust with corresponding elements in coal fly ash; and (3) comparison of 23 elements analyzed in fibrous mesh found after snow melted with corresponding elements in coal fly ash...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27421578/perinatal-triphenyl-phosphate-exposure-accelerates-type-2-diabetes-onset-and-increases-adipose-accumulation-in-ucd-type-2-diabetes-mellitus-rats
#13
Adrian J Green, James L Graham, Eduardo A Gonzalez, Michael R La Frano, Syrago-Styliani E Petropoulou, June-Soo Park, John W Newman, Kimber L Stanhope, Peter J Havel, Michele A La Merrill
Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively...
March 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/27355220/-the-offer-of-medical-diagnostic-self-tests-on-german-language-websites-results-of-a-systematic-internet-search
#14
P Kuecuekbalaban, S Schmidt, H Muehlan
Aim of the study: The aim of the current study was to provide an overview of medical-diagnostic self-tests which can be purchased without a medical prescription on German language websites. Method: From September 2014 to March 2015, a systematic internet research was conducted with the following search terms: self-test, self-diagnosis, home test, home diagnosis, quick test, rapid test. Results: 513 different self-tests for the diagnostics of 52 diverse diseases or health risks were identified, including chronic diseases (e...
June 29, 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/26900394/health-status-of-male-steel-workers-at-an-electric-arc-furnace-eaf-in-trentino-italy
#15
Roberto Cappelletti, Marcello Ceppi, Justina Claudatus, Valerio Gennaro
BACKGROUND: The aim of this retrospective cohort study was to determine if the workers of an Electric Arc Furnace (EAF), which recycles scrap, had higher mortality and morbidity due to possible exposure to pollutants at work. EAFs do not run on coke ovens. In EAFs 40 % of the particulate matter (PM) is made up of PM 2.5. The foundry dust contained iron, aluminum, zinc, manganese, lead, chromium, nickel, cadmium, mercury, arsenic, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls and dioxins...
2016: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/26510439/redox-mechanisms-in-pathological-angiogenesis-in-the-retina-roles-for-nadph-oxidase
#16
REVIEW
Elsa C Chan, Guei-Sheung Liu, Gregory J Dusting
Pathological angiogenesis in the retina is a leading cause of serious vision loss in potentially blinding eye diseases, including proliferative diabetic retinopathy, retinopathy of prematurity and the wet form of age-related macular degeneration. Hypoxia is thought to be the driver of pathological angiogenesis, and transcription factors such as hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF) are key mediators in these processes. Current treatments employ either laser photocoagulation or intravitreal injection of therapeutic antibodies for VEGF, in order to arrest the growth of leaky blood vessels in the avascular vitreous cavity and to restore visual acuity...
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26213331/ganoderma-neo-japonicum-imazeki-revisited-domestication-study-and-antioxidant-properties-of-its-basidiocarps-and-mycelia
#17
Wee-Cheat Tan, Umah Rani Kuppusamy, Chia-Wei Phan, Yee-Shin Tan, Jegadeesh Raman, Azliza Mad Anuar, Vikineswary Sabaratnam
Mushroom cultivation benefits humankind as it deliberately encourages wild mushrooms to be commercially propagated while recycling agricultural wastes. Ganoderma neo-japonicum is a rare polypore mushroom found growing on decaying Schizostachyum brachycladium (a tropical bamboo) clumps in Malaysia. The Malaysian indigenous tribes including the Temuans and Temiars use the basidiocarps of G. neo-japonicum to treat various ailments including diabetes. In this study, the domestication of G. neo-japonicum in artificial logs of different agricultural residues was investigated...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26125818/analysis-of-the-gstm1-null-polymorphism-in-patients-with-pterygium-from-goi%C3%A3-nia-goi%C3%A3-s-brazil
#18
A de P R Júnior, G M Dos Reis, K S F E Silva, D A Rodrigues, M C S Gomes, J V M Martins, I R da Costa, G A Freitas, K K V O Moura
The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, including heat, dust, and other particles in the atmosphere, and immunological mechanisms, mechanisms involving extracellular matrix reorganization, growth factors, cytokines, apoptosis, and angiogenesis...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/26105974/bisphenol-a-environmental-exposure-and-the-detrimental-effects-on-human-metabolic-health-is-it-necessary-to-revise-the-risk-assessment-in-vulnerable-population
#19
REVIEW
R Valentino, V D'Esposito, F Ariemma, I Cimmino, F Beguinot, P Formisano
In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on human health. BPA, a common and widely chemical contaminant acting as endocrine disruptor, accumulates in adipose tissue and may affect adipocyte metabolic and inflammatory functions. BPA, at low chronic doses, is now considered as an obesogen compound, and might contribute to the rise of metabolic syndrome, visceral adiposity and diabetes epidemics. The BPA worldwide presence in the environment is responsible for chronic exposure during vulnerable periods, such as foetal and neonatal life...
March 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/25957500/extracoronary-thoracic-and-coronary-artery-calcifications-on-chest-ct-for-lung-cancer-screening-association-with-established-cardiovascular-risk-factors-the-ct-risk-trial
#20
REVIEW
Timm Dirrichs, Tobias Penzkofer, Sebastian D Reinartz, Thomas Kraus, Andreas H Mahnken, Christiane K Kuhl
RATIONALE AND OBJECTIVES: To investigate the correlation between prevalence and degree of coronary artery calcification (CAC) and extracoronary calcifications (ECCs), scored quantitatively according to Agatston and semiquantitatively by visual analysis, in chest computed tomography (CT) studies obtained for lung cancer screening in asymptomatic subjects and in patients with known coronary heart disease (CHD), and to compare the association of ECC and CAC to established cardiovascular risk factors...
July 2015: Academic Radiology
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