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Dust and diabet

Małgorzata Kowalska, Krzysztof Kocot
Results of epidemiological studies suggest a significant impact of ambient particulate matter air pollution (PM10 and PM2,5) on the health of the population. Increased level of these pollutants is connected with increased rate of daily mortality and hospitalizations due to cardiovascular diseases. Among analyzed health effects, heart arrhythmias and stroke are mentioned most frequently. The aim of the study was to present the current knowledge of potential influence of the exposure to fine particulate matter on the presence of arrhythmias and strokes...
September 28, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
J Marvin Herndon
BACKGROUND: U.S. military perception of nuclear warfare led to countless unethical nuclear experiments performed on unsuspecting individuals without their informed consent. As evidenced here, subsequent perception of weather warfare has led to exposing millions of unsuspecting individuals to toxic coal fly ash with no public disclosure, no informed consent, and no health warnings. METHODS: Three methods were used: (1) comparison of eight elements analyzed in rainwater samples, thought to have leached from aerosolized coal fly ash, with corresponding coal fly ash laboratory leachate; (2) comparison of 14 elements analyzed in air filter dust with corresponding elements in coal fly ash; and (3) comparison of 23 elements analyzed in fibrous mesh found after snow melted with corresponding elements in coal fly ash...
2016: Frontiers in Public Health
Adrian J Green, James L Graham, Eduardo A Gonzalez, Michael R La Frano, Syrago-Styliani E Petropoulou, June-Soo Park, John W Newman, Kimber L Stanhope, Peter J Havel, Michele A La Merrill
Triphenyl phosphate (TPhP) is a flame retardant additive frequently found in consumer products and household dust. We administered 170μg of TPhP in maternal food from gestational day 8.5 to weaning and evaluated metabolic phenotypes of 3.5 month old male and female rats, and weight-matched males up to 6 months, to assess the development of obesity and type 2 diabetes mellitus (T2DM), respectively. Perinatal TPhP exposure increased body and fat mass in 3.5 month old male and female rats, while leptin and cumulative energy intake were elevated in males and females, respectively...
July 12, 2016: Reproductive Toxicology
P Kuecuekbalaban, S Schmidt, H Muehlan
Aim of the study: The aim of the current study was to provide an overview of medical-diagnostic self-tests which can be purchased without a medical prescription on German language websites. Method: From September 2014 to March 2015, a systematic internet research was conducted with the following search terms: self-test, self-diagnosis, home test, home diagnosis, quick test, rapid test. Results: 513 different self-tests for the diagnostics of 52 diverse diseases or health risks were identified, including chronic diseases (e...
June 29, 2016: Das Gesundheitswesen
Roberto Cappelletti, Marcello Ceppi, Justina Claudatus, Valerio Gennaro
BACKGROUND: The aim of this retrospective cohort study was to determine if the workers of an Electric Arc Furnace (EAF), which recycles scrap, had higher mortality and morbidity due to possible exposure to pollutants at work. EAFs do not run on coke ovens. In EAFs 40 % of the particulate matter (PM) is made up of PM 2.5. The foundry dust contained iron, aluminum, zinc, manganese, lead, chromium, nickel, cadmium, mercury, arsenic, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls and dioxins...
2016: Journal of Occupational Medicine and Toxicology
Elsa C Chan, Guei-Sheung Liu, Gregory J Dusting
Pathological angiogenesis in the retina is a leading cause of serious vision loss in potentially blinding eye diseases, including proliferative diabetic retinopathy, retinopathy of prematurity and the wet form of age-related macular degeneration. Hypoxia is thought to be the driver of pathological angiogenesis, and transcription factors such as hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF) are key mediators in these processes. Current treatments employ either laser photocoagulation or intravitreal injection of therapeutic antibodies for VEGF, in order to arrest the growth of leaky blood vessels in the avascular vitreous cavity and to restore visual acuity...
2015: Current Pharmaceutical Design
Wee-Cheat Tan, Umah Rani Kuppusamy, Chia-Wei Phan, Yee-Shin Tan, Jegadeesh Raman, Azliza Mad Anuar, Vikineswary Sabaratnam
Mushroom cultivation benefits humankind as it deliberately encourages wild mushrooms to be commercially propagated while recycling agricultural wastes. Ganoderma neo-japonicum is a rare polypore mushroom found growing on decaying Schizostachyum brachycladium (a tropical bamboo) clumps in Malaysia. The Malaysian indigenous tribes including the Temuans and Temiars use the basidiocarps of G. neo-japonicum to treat various ailments including diabetes. In this study, the domestication of G. neo-japonicum in artificial logs of different agricultural residues was investigated...
2015: Scientific Reports
A de P R Júnior, G M Dos Reis, K S F E Silva, D A Rodrigues, M C S Gomes, J V M Martins, I R da Costa, G A Freitas, K K V O Moura
The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, including heat, dust, and other particles in the atmosphere, and immunological mechanisms, mechanisms involving extracellular matrix reorganization, growth factors, cytokines, apoptosis, and angiogenesis...
2015: Genetics and Molecular Research: GMR
R Valentino, V D'Esposito, F Ariemma, I Cimmino, F Beguinot, P Formisano
In the last decades, many reports have focused the attention on deleterious effects of novel environmental chemical compounds, including bisphenol A (BPA), on human health. BPA, a common and widely chemical contaminant acting as endocrine disruptor, accumulates in adipose tissue and may affect adipocyte metabolic and inflammatory functions. BPA, at low chronic doses, is now considered as an obesogen compound, and might contribute to the rise of metabolic syndrome, visceral adiposity and diabetes epidemics. The BPA worldwide presence in the environment is responsible for chronic exposure during vulnerable periods, such as foetal and neonatal life...
March 2016: Journal of Endocrinological Investigation
Timm Dirrichs, Tobias Penzkofer, Sebastian D Reinartz, Thomas Kraus, Andreas H Mahnken, Christiane K Kuhl
RATIONALE AND OBJECTIVES: To investigate the correlation between prevalence and degree of coronary artery calcification (CAC) and extracoronary calcifications (ECCs), scored quantitatively according to Agatston and semiquantitatively by visual analysis, in chest computed tomography (CT) studies obtained for lung cancer screening in asymptomatic subjects and in patients with known coronary heart disease (CHD), and to compare the association of ECC and CAC to established cardiovascular risk factors...
July 2015: Academic Radiology
Mandar S Joshi, David Williams, Duncan Horlock, Thilini Samarasinghe, Karen L Andrews, Ann-Maree Jefferis, Philip J Berger, Jaye P Chin-Dusting, David M Kaye
Microvascular complications are now recognized to play a major role in diabetic complications, and understanding the mechanisms is critical. Endothelial dysfunction occurs early in the course of the development of complications; the precise mechanisms remain poorly understood. Mitochondrial dysfunction may occur in a diabetic rat heart and may act as a source of the oxidative stress. However, the role of endothelial cell-specific mitochondrial dysfunction in diabetic vascular complications is poorly studied...
May 2015: Diabetes & Vascular Disease Research
Dorina Gabriela Karottki, Gabriel Bekö, Geo Clausen, Anne Mette Madsen, Zorana Jovanovic Andersen, Andreas Massling, Matthias Ketzel, Thomas Ellermann, Rikke Lund, Torben Sigsgaard, Peter Møller, Steffen Loft
This cross-sectional study investigated the relationship between exposure to airborne indoor and outdoor particulate matter (PM) and cardiovascular and respiratory health in a population-based sample of 58 residences in Copenhagen, Denmark. Over a 2-day period indoor particle number concentrations (PNC, 10-300 nm) and PM2.5 (aerodynamic diameter<2.5 μm) were monitored for each of the residences in the living room, and outdoor PNC (10-280 nm), PM2.5 and PM10 (aerodynamic diameter<10 μm) were monitored at an urban background station in Copenhagen...
December 2014: Environment International
Ivy Shiue, Glen Bramley
Housing conditions affect occupants continuously, and health interventions have shown a positive association between housing investment or improvement and occupant's health. However, the sources of the housing problems were less understood. Since it was observed that lead dust and chloroanisoles released from housing (materials) as indoor pollutants affected child's health, we now aimed to examine the relationships among built year, environmental chemicals and individual health in adults in a national and population-based setting...
January 2015: Environmental Science and Pollution Research International
Hye-Sun Lim, Hyekyung Ha, Hoyoung Lee, Jun Kyung Lee, Mee-Young Lee, Hyeun-Kyoo Shin
BACKGROUND: Morus alba, a medicinal plant in Asia, has been used traditionally to treat diabetes mellitus and hypoglycemia. However, the effects of M. alba extract (MAE) on atopic dermatitis have not been verified scientifically. We investigated the effects of MAE on atopic dermatitis through in vitro and in vivo experiments. METHODS: We evaluated the effects of MAE on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7, as well as thymus and activation-regulated chemokine (TARC/CCL17) in HaCaT cells...
2014: BMC Complementary and Alternative Medicine
Annet Oliveira, Jagdish Cacodcar, D D Motghare
This study was carried out among workers from an open-cast iron ore mine in South Goa with an objective to assess morbidity among these workers. Investigations were carried out at the Occupational Health Service Clinic of the mining company. Nearly 0.6% workers had pneumoconiosis, 3.2% had abnormal spirometry findings, 38.16% had hearing loss and 27.7% had defective vision respectively. The prevalence of other chronic diseases were as follows: diabetes 5.1%, hypertension 8.3%, dyslipidemia 37.5% and polycythemia 12...
January 2014: Indian Journal of Public Health
Robert M Brackbill, James E Cone, Mark R Farfel, Steven D Stellman
Few studies have focused on injuries from the World Trade Center disaster on September 11, 2001. Severe injury has health consequences, including an increased mortality risk 10 years after injury and the risk of mental health problems, such as posttraumatic stress disorder (PTSD). The World Trade Center Health Registry identified 14,087 persons with none of a selected group of preexisting chronic conditions before 2002 who were present during and soon after the World Trade Center attacks, 1,980 of whom reported sustaining 1 or more types of injury (e...
May 1, 2014: American Journal of Epidemiology
M B Rabinowitz, H L Needleman
Blood lead was measured at birth for 11,837 infants in Boston. Extensive maternal demographic, pregnancy, and delivery characteristics were recorded for 4354 of them. For 249 of these, intensive environmental sampling was done. Many medical factors were unrelated to blood lead, including diabetes, venereal diseases, preeclampsia, toxemia, hypertension, age, hematocrit, contraceptive use, presentation, type of delivery, fetal distress, premature rupture of membrane, blood type, gestational age, birthweight, Apgar score, jaundice, and mortality by one month...
February 1984: Biological Trace Element Research
Elsa C Chan, Peter van Wijngaarden, Guei-Sheung Liu, Fan Jiang, Hitesh Peshavariya, Gregory J Dusting
PURPOSE: The proliferation of new blood vessels in the retina is a leading cause of vision impairment. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) is involved in cell signaling for ischemia-induced angiogenesis, but its role in retinal neovascularization is unclear. We have analyzed the dependence of retinal neovascularization on the Nox2 isoform in oxygen-induced retinopathy (OIR) in mice. METHODS: Neonatal C57BL/6 mice aged 7 days (P7) were placed in a hyperoxic chamber (75% O2) for 5 days, followed by 5 days of exposure to room air...
2013: Investigative Ophthalmology & Visual Science
Martín Bedolla-Barajas, Jaime Morales-Romero, Dante D Hernández-Colìn, David Arévalo-Cruz
BACKGROUND: Allergic diseases affect a great proportion of seniors. OBJECTIVE: To determine the prevalence of allergen sensitization in this age group in the western of Mexico. METHODS: A retrolective study related to skin prick tests with a common allergen panel was performed on the first consultation in elderly patients during a period of three years in Guadalajara, Mexico. RESULTS: We included 60 subjects, with an average of 67...
July 2012: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Natalie G Lumsden, Karen L Andrews, Maria Bobadilla, Xiao L Moore, Amanda K Sampson, James A Shaw, Jacques Mizrahi, David M Kaye, Anthony M Dart, Jaye P F Chin-Dusting
UNLABELLED: This single visit study examined whether endothelial function, in addition to cardiovascular (CV) risk factors and plasma microparticle content, was normalised in 15 patients with type 2 diabetes + acute coronary syndrome (ACS) (6 weeks-6 months post cardiac event) undergoing standard clinical care compared to 16 sex- and age-matched healthy controls. RESULTS: While total and low-density lipoprotein (LDL) cholesterol levels were well controlled in the patients with type 2 diabetes + ACS, residual CV risk profiles such as increased body mass index (BMI), systolic blood pressure, glucose levels and triglycerides and lower high-density lipoprotein (HDL) levels were still apparent...
July 2013: Diabetes & Vascular Disease Research
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