keyword
https://read.qxmd.com/read/38416181/-prevention-of-dementia
#21
JOURNAL ARTICLE
Walter M Schippinger, Gerald Pichler
With increasing life expectancy, the prevalence of dementia is increasing worldwide. Dementia is among the greatest challenges for healthcare and social systems of the future. Approximately 40% of newly diagnosed cases of dementia are associated with risk factors that can potentially be influenced by preventive measures. Based on the evidence from longitudinal studies, systematic reviews and meta-analyses, the Lancet commission on dementia prevention, intervention and care has defined 12 risk factors that are associated with an increased risk for dementia: low level of education, hearing impairment, traumatic brain injury, arterial hypertension, diabetes mellitus, smoking, excessive alcohol consumption, depression, obesity, social isolation, and air pollution...
February 28, 2024: Der Nervenarzt
https://read.qxmd.com/read/38408229/dinickel-enzyme-evolved-to-metabolize-the-pharmaceutical-metformin-and-its-implications-for-wastewater-and-human-microbiomes
#22
JOURNAL ARTICLE
Lambros J Tassoulas, Joel A Rankin, Mikael H Elias, Lawrence P Wackett
Metformin is the first-line treatment for type II diabetes patients and a pervasive pollutant with more than 180 million kg ingested globally and entering wastewater. The drug's direct mode of action is currently unknown but is linked to effects on gut microbiomes and may involve specific gut microbial reactions to the drug. In wastewater treatment plants, metformin is known to be transformed by microbes to guanylurea, although genes encoding this metabolism had not been elucidated. In the present study, we revealed the function of two genes responsible for metformin decomposition ( mfmA and mfmB ) found in isolated bacteria from activated sludge...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38407634/impacts-of-heatwaves-on-type-2-diabetes-mortality-in-china-a-comparative-analysis-between-coastal-and-inland-cities
#23
JOURNAL ARTICLE
Wenxiu Zheng, Jie Chu, Hilary Bambrick, Ning Wang, Kerrie Mengersen, Xiaolei Guo, Wenbiao Hu
The impacts of extreme temperatures on diabetes have been explored in previous studies. However, it is unknown whether the impacts of heatwaves appear variations between inland and coastal regions. This study aims to quantify the associations between heat exposure and type 2 diabetes mellitus (T2DM) deaths in two cities with different climate features in Shandong Province, China. We used a case-crossover design by quasi-Poisson generalized additive regression with a distributed lag model with lag 2 weeks, controlling for relative humidity, the concentration of air pollution particles with a diameter of 2...
February 26, 2024: International Journal of Biometeorology
https://read.qxmd.com/read/38405987/outdoor-nighttime-light-exposure-light-pollution-is-associated-with-alzheimer-s-disease
#24
Robin M Voigt, Bichun Ouyang, Ali Keshavarzian
UNLABELLED: Alzheimer's disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. This study evaluated the relationship between outdoor nighttime light exposure and AD prevalence in the United States. Higher outdoor nighttime light was associated with higher prevalence of AD. While atrial fibrillation, diabetes, hyperlipidemia, hypertension, and stroke were associated more strongly with AD prevalence than nighttime light intensity, nighttime light was more strongly associated with AD prevalence than alcohol abuse, chronic kidney disease, depression, heart failure, and obesity...
February 15, 2024: medRxiv
https://read.qxmd.com/read/38397722/enhancing-behavioural-changes-a-narrative-review-on-the-effectiveness-of-a-multifactorial-app-based-intervention-integrating-physical-activity
#25
REVIEW
Giulia Di Martino, Carlo Della Valle, Marco Centorbi, Andrea Buonsenso, Giovanni Fiorilli, Giuseppe Calcagno, Enzo Iuliano, Alessandra di Cagno
The rapid evolution of technologies is a key innovation in the organisation and management of physical activities (PA) and sports. The increase in benefits and opportunities related to the adoption of technologies for both the promotion of a healthy lifestyle and the management of chronic diseases is evident. In the field of telehealth, these devices provide personalised recommendations, workout monitoring and injury prevention. The study aimed to provide an overview of the landscape of technology application to PA organised to promote active lifestyles and improve chronic disease management...
February 16, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38397687/burden-of-disease-due-to-air-pollution-in-afghanistan-results-from-the-global-burden-of-disease-study-2019
#26
JOURNAL ARTICLE
Omar Hahad
INTRODUCTION: Air pollution is a significant risk factor for a range of diseases and leads to substantial disease burden and deaths worldwide. This study aimed to investigate the burden of disease in Afghanistan attributed to air pollution in 2019. METHODS: Data from the Global Burden of Disease (GBD) Study 2019 were used to investigate disability-adjusted life-years (DALYs), years of life lost (YLLs), years lived with disability (YLDs), and deaths attributed to air pollution in Afghanistan...
February 8, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38397682/does-intrauterine-exposure-to-diabetes-impact-mental-and-motor-skills-a-meta-analysis-of-the-bayley-scales-of-infant-development
#27
REVIEW
Diana Arabiat, Mohammad Al Jabery, Lisa Whitehead
BACKGROUND: Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. METHODS: PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched...
February 7, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38397668/literary-identification-of-differentially-hydroxymethylated-dna-regions-for-type-2-diabetes-mellitus-a-scoping-minireview
#28
REVIEW
Ryan Anh Minh Luong, Weihua Guan, Fue Chee Vue, Jun Dai
Type 2 diabetes mellitus (T2DM) is a public health condition where environmental and genetic factors can intersect through hydroxymethylation. It was unclear which blood DNA regions were hydroxymethylated in human T2DM development. We aimed to identify the regions from the literature as designed in the ongoing Twins Discordant for Incident T2DM Study. A scoping review was performed using Medical Subject Headings (MeSH) and keyword methods to search PubMed for studies published in English and before 1 August 2022, following our registered protocol...
February 4, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38397639/-it-s-not-that-we-care-less-insights-into-health-care-utilization-for-comorbid-diabetes-and-depression-among-latinos
#29
JOURNAL ARTICLE
Sharon Borja, Miriam G Valdovinos, Kenia M Rivera, Natalia Giraldo-Santiago, Robin E Gearing, Luis R Torres
Despite robust knowledge regarding the socio-economic and cultural factors affecting Latino* access to healthcare, limited research has explored service utilization in the context of comorbid conditions like diabetes and depression. This qualitative study, embedded in a larger mixed-methods project, aimed to investigate perceptions held by Latinos and their social support systems (i.e., family members) regarding comorbid diabetes and depression and to identify barriers and facilitators to their help-seeking behaviors and treatment engagement...
January 29, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38393201/increased-perfluorooctanesulfonate-pfos-toxicity-and-accumulation-is-associated-with-perturbed-prostaglandin-metabolism-and-increased-organic-anion-transport-protein-oatp-expression
#30
JOURNAL ARTICLE
Lanie A Williams, Matthew C Hamilton, Matthew L Edin, Fred B Lih, Jazmine A Eccles-Miller, Nishanth Tharayil, Elizabeth Leonard, William S Baldwin
Perfluorooctanesulfonate (PFOS) is a widespread environmental pollutant with a long half-life and clearly negative outcomes on metabolic diseases such as fatty liver disease and diabetes. Male and female Cyp2b-null and humanized CYP2B6-transgenic (hCYP2B6-Tg) mice were treated with 0, 1, or 10 mg/kg/day PFOS for 21 days, and surprisingly it was found that PFOS was retained at greater concentrations in the serum and liver of hCYP2B6-Tg mice than those of Cyp2b-null mice, with greater differences in the females...
January 26, 2024: Toxics
https://read.qxmd.com/read/38393000/deciphering-the-role-of-the-gut-microbiota-in-exposure-to-emerging-contaminants-and-diabetes-a-review
#31
REVIEW
Xueqing Li, Huixia Niu, Zhengliang Huang, Man Zhang, Mingluan Xing, Zhijian Chen, Lizhi Wu, Peiwei Xu
Emerging pollutants, a category of compounds currently not regulated or inadequately regulated by law, have recently become a focal point of research due to their potential toxic effects on human health. The gut microbiota plays a pivotal role in human health; it is particularly susceptible to disruption and alteration upon exposure to a range of toxic environmental chemicals, including emerging contaminants. The disturbance of the gut microbiome caused by environmental pollutants may represent a mechanism through which environmental chemicals exert their toxic effects, a mechanism that is garnering increasing attention...
February 6, 2024: Metabolites
https://read.qxmd.com/read/38386816/study-attributes-5-million-deaths-per-year-to-air-pollution
#32
JOURNAL ARTICLE
Karen Roush
Diabetes and stroke are among pollution-related diseases.
March 1, 2024: American Journal of Nursing
https://read.qxmd.com/read/38382346/ps-mps-promotes-the-progression-of-inflammation-and-fibrosis-in-diabetic-nephropathy-through-nlrp3-caspase-1-and-tgf-%C3%AE-1-smad2-3-signaling-pathways
#33
JOURNAL ARTICLE
Lixiang Feng, Chen Chen, Xi Xiong, Xiong Wang, Xinxin Li, Qihui Kuang, Xiao Wei, Likun Gao, Xuan Niu, Qingwen Li, Jun Yang, Lili Li, Pengcheng Luo
BACKGROUND: Diabetic nephropathy (DN) is a prevalent chronic microvascular complication of diabetes and the leading cause of end-stage renal disease (ESRD). Understanding the progressive etiology of DN is critical for the development of effective health policies and interventions. Recent research indicated that polystyrene microplastics (PS-MPs) contaminate our diets and accumulate in various organs, including the liver, kidneys, and muscles. METHODS: In this study, ten-week-old db/db mice and db/m mice were fed...
February 20, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38377899/association-between-ambient-pm-1-and-the-prevalence-of-chronic-kidney-disease-in-china-a-nationwide-study
#34
JOURNAL ARTICLE
Rui Chen, Chao Yang, Yuming Guo, Gongbo Chen, Shanshan Li, Pengfei Li, Jinwei Wang, Ruogu Meng, Huai-Yu Wang, Suyuan Peng, Xiaoyu Sun, Fulin Wang, Guilan Kong, Luxia Zhang
Particulate of diameter ≤ 1 µm (PM1 ) presents a novel risk factor of adverse health effects. Nevertheless, the association of PM1 with the risk of chronic kidney disease (CKD) in the general population is not well understood, particularly in regions with high PM1 levels like China. Based on a nationwide representative survey involving 47,204 adults and multi-source ambient air pollution inversion data, the present study evaluated the association of PM1 with CKD prevalence in China. The two-year average PM1 , particulate of diameter ≤ 2...
February 17, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38368966/altered-igf2-imprint-leads-to-accelerated-adipogenesis-and-early-onset-of-metabolic-syndrome-in-male-mice-following-gestational-arsenic-exposure
#35
JOURNAL ARTICLE
Kavita Koshta, Anchal Chauhan, Sukhveer Singh, Anil Nilkanth Gaikwad, Mahadeo Kumar, Vikas Srivastava
Developmental exposure to environmental pollutants has been shown to promote adverse health outcomes in offspring. Exposure to heavy metals such as arsenic which also has endocrine-disrupting activity is being increasingly linked with cancers, diabetes, and lately with Metabolic Syndrome (MetS). In this work, we have assessed the effects of preconceptional plus gestational arsenic exposure on the developmental programming of MetS in offspring. In our study, only gestational arsenic exposure led to reduced birth weight, followed by catch-up growth, adiposity, elevated serum triglycerides levels, and hyperglycemia in male offspring...
February 16, 2024: Chemosphere
https://read.qxmd.com/read/38367088/ethnobotanical-ecological-and-health-risk-assessment-of-some-selected-wild-medicinal-plants-collected-along-mafic-and-ultra-mafic-rocks-of-northwest-pakistan
#36
JOURNAL ARTICLE
Irfan Ullah, Muhammad Adnan, Javed Nawab, Sardar Khan
The current study investigated wild plant resources and health risk assessment along with northern Pakistan's mafic and ultramafic regions. Ethnobotanical data was collected through field visits and semi-structured questionnaire surveys conducted from local inhabitants and healers. Six potentially toxic elements (PTEs) such as lead (Pb), cadmium (Cd), nickel (Ni), chromium (Cr), manganese (Mn), and zinc (Zn) were extracted with acids and analyzed using atomic absorption spectrophotometer (AAS, Perkin Elmer-7000) in nine selected wild medicinal plants...
February 17, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38364759/metformin-alleviates-benzo-a-pyrene-induced-alveolar-injury-by-inhibiting-necroptosis-and-protecting-at2-cells
#37
JOURNAL ARTICLE
Mei-Yu Quan, Xihua Yan, Wanqi Miao, Xue Li, Jiaqi Li, Linglong Yang, Chenhua Yu, Yanxia Zhang, Weiwei Yang, Chengyang Zou, Bin Liu, Xuru Jin, Chengshui Chen, Qiang Guo, Jin-San Zhang
Exposure to benzo[a]pyrene (B[a]P) has been linked to lung injury and carcinogenesis. Airway epithelial cells express the B[a]P receptor AHR, so B[a]P is considered to mainly target airway epithelial cells, whereas its potential impact on alveolar cells remains inadequately explored. Metformin, a first-line drug for diabetes, has been shown to exert anti-inflammatory and tissue repair-promoting effects under various injurious conditions. Here, we explored the effect of chronic B[a]P exposure on alveolar cells and the impact of metformin on B[a]P-induced lung injury by examining the various parameters including lung histopathology, inflammation, fibrosis, and related signal pathway activation...
February 15, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38363509/the-mediation-effect-of-asprosin-on-the-association-between-ambient-air-pollution-and-diabetes-mellitus-in-the-elderly-population-in-taiyuan-china
#38
JOURNAL ARTICLE
Lulu Song, Yuhui Gao, Jiayu Tian, Nannan Liu, Halimaimaiti Nasier, Caihong Wang, Huiqiu Zhen, Linlin Guan, Zeyu Niu, Dongxing Shi, Hongmei Zhang, Lifang Zhao, Zhihong Zhang
Evidence around the relationship between air pollution and the development of diabetes mellitus (DM) remains limited and inconsistent. To investigate the potential mediation effect of asprosin on the association between fine particulate matter (PM2.5 ), tropospheric ozone (O3 ) and blood glucose homeostasis. A case-control study was conducted on a total of 320 individuals aged over 60 years, including both diabetic and non-diabetic individuals, from six communities in Taiyuan, China, from July to September 2021...
February 16, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38356441/ellagic-acid-protects-against-angiotensin-ii-induced-hypertrophic-responses-through-ros-mediated-mapk-pathway-in-h9c2-cells
#39
JOURNAL ARTICLE
Ya-Che Lee, Yeong-Chin Jou, Wan-Ching Chou, Kun-Ling Tsai, Cheng-Huang Shen, Shin-Da Lee
The early myocardial response of hypertension is an elevation of angiotensin-II (Ang-II) concentration, leading to heart failure and cardiac hypertrophy. This hypertrophic event of the heart is mediated by the interaction of Ang type 1 receptors (AT-R1), thereby modulating NADPH oxidase activity in cardiomyocytes, which alters redox status in cardiomyocytes. Ellagic acid (EA) has anti-inflammatory and anti-oxidative capacities. Thus, EA has potential preventive effects on cardiovascular diseases and diabetes...
February 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38340600/sex-specific-non-linear-and-congener-specific-association-between-mixed-exposure-to-polychlorinated-biphenyls-pcbs-and-diabetes-in-u-s-adults
#40
JOURNAL ARTICLE
Keyu Pan, Huixun Jia, Renjie Chen, Chang Su, Huijun Wang, Tao Zhang, Zhenyu Wu
BACKGROUND: Whether and to what extent the impact of exposure to various polychlorinated biphenyls (PCBs) congeners on diabetes, as well as the important contributors, have remained unclear. OBJECTIVE: We aimed to investigate the association patterns between PCBs mixture and diabetes, identify the critical congeners, and explore the potential modifiers. METHODS: The present study included 5900 U.S. adults from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2016...
February 9, 2024: Ecotoxicology and Environmental Safety
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