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Pollution and diabet

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https://www.readbyqxmd.com/read/29142003/disparities-in-environmental-exposures-to-endocrine-disrupting-chemicals-and-diabetes-risk-in-vulnerable-populations
#1
Daniel Ruiz, Marisol Becerra, Jyotsna S Jagai, Kerry Ard, Robert M Sargis
Burgeoning epidemiological, animal, and cellular data link environmental endocrine-disrupting chemicals (EDCs) to metabolic dysfunction. Disproportionate exposure to diabetes-associated EDCs may be an underappreciated contributor to disparities in metabolic disease risk. The burden of diabetes is not uniformly borne by American society; rather, this disease disproportionately affects certain populations, including African Americans, Latinos, and low-income individuals. The purpose of this study was to review the evidence linking unequal exposures to EDCs with racial, ethnic, and socioeconomic diabetes disparities in the U...
November 15, 2017: Diabetes Care
https://www.readbyqxmd.com/read/29118034/cardiovascular-effects-of-long-term-exposure-to-air-pollution-a-population-based-study-with-900%C3%A2-845%C3%A2-person-years-of-follow-up
#2
Hyeanji Kim, Joonghee Kim, Sunhwa Kim, Si-Hyuck Kang, Hee-Jun Kim, Ho Kim, Jongbae Heo, Seung-Muk Yi, Kyuseok Kim, Tae-Jin Youn, In-Ho Chae
BACKGROUND: Studies have shown that long-term exposure to air pollution such as fine particulate matter (≤2.5 μm in aerodynamic diameter [PM2.5]) increases the risk of all-cause and cardiovascular mortality. To date, however, there are limited data on the impact of air pollution on specific cardiovascular diseases. This study aimed to evaluate cardiovascular effects of long-term exposure to air pollution among residents of Seoul, Korea. METHODS AND RESULTS: Healthy participants with no previous history of cardiovascular disease were evaluated between 2007 and 2013...
November 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29118024/arsenic-exposure-induces-glucose-intolerance-and-alters-global-energy-metabolism
#3
Andrew G Kirkley, Christopher M Carmean, Daniel Ruiz, Honggang Ye, Shane M Regnier, Ananta Poudel, Manami Hara, Wakanene Kamau, Daniel N Johnson, Austin A Roberts, Patrick J Parsons, Susumu Seino, Robert Michael Sargis
Environmental pollutants acting as endocrine disrupting chemicals (EDCs) are recognized as potential contributors to metabolic disease pathogenesis. One such pollutant, arsenic, contaminates the drinking water of approximately 100 million people globally and has been associated with insulin resistance and diabetes in epidemiological studies. Despite these observations, the precise metabolic derangements induced by arsenic remain incompletely characterized. In the present study, arsenic's impact on in vivo metabolic physiology was examined in 8 week old male C57BL/6J mice exposed to 50 mg/L inorganic arsenite in their drinking water for 8 weeks...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29117118/diet-and-asthma-is-it-time-to-adapt-our-message
#4
REVIEW
Laurent Guilleminault, Evan J Williams, Hayley A Scott, Bronwyn S Berthon, Megan Jensen, Lisa G Wood
Asthma is a chronic respiratory disorder which is associated with airway inflammation. Environmental factors, in association with genetic susceptibility, play a critical role in asthma pathophysiology. Inhaled allergens, smoke exposure, indoor and outdoor air pollution are common triggers of asthma symptoms. Although the role of diet has clearly established mechanisms in diseases such as cardiovascular disease, type 2 diabetes, and cancer, it is not commonly identified as a causal factor in asthma. However, some dietary patterns, such as the Western diet, which includes a high intake of refined grains, processed and red meats, and desserts, have pro-inflammatory effects...
November 8, 2017: Nutrients
https://www.readbyqxmd.com/read/29111283/pancreatic-islet-autonomous-effect-of-arsenic-on-insulin-secretion-through-endoplasmic-reticulum-stress-autophagy-pathway
#5
Wei Wu, Xiaofeng Yao, Liping Jiang, Qiaoting Zhang, Jie Bai, Tianming Qiu, Lei Yang, Ni Gao, Guang Yang, Xiaofang Liu, Min Chen, Xiance Sun
Inorganic arsenic is a worldwide environmental pollutant. Arsenic's relationship with the incidence of diabetes arouses concerns on its etiological mechanism. In this study, the glucose-stimulated insulin secretion (GSIS) from isolated pancreatic islets of As2O3-treated mice was significantly lower than that of control mice. It indicated that the effect of As2O3-inhibited GSIS was pancreatic islet-autonomous. The level of phospho-PERK (p-PERK), a biomarker of endoplasmic reticulum (ER) stress, in pancreas of As2O3-treated mice was increased significantly...
October 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29103043/examining-the-relationship-between-trace-lithium-in-drinking-water-and-the-rising-rates-of-age-adjusted-alzheimer-s-disease-mortality-in-texas
#6
Val Andrew Fajardo, Val Andrei Fajardo, Paul J LeBlanc, Rebecca E K MacPherson
BACKGROUND: Alzheimer's disease (AD) mortality rates have steadily increased over time. Lithium, the current gold standard treatment for bipolar disorder, can exert neuroprotective effects against AD. OBJECTIVE: We examined the relationship between trace levels of lithium in drinking water and changes in AD mortality across several Texas counties. METHODS: 6,180 water samples from public wells since 2007 were obtained and averaged for 234 of 254 Texas counties...
October 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29101696/effect-of-long-term-exposure-to-ambient-particulate-matter-on-prevalence-of-type-2-diabetes-and-hypertension-in-iranian-adults-an-ecologic-study
#7
Mohammad Sadegh Hassanvand, Kazem Naddafi, Mojtaba Malek, Ameneh Ebrahim Valojerdi, Mohanad Mirzadeh, Tahereh Samavat, Alireza Mahdavi Hezaveh, Alieh Hodjatzadeh, Mohammad Ebrahim Khamseh
Air pollution is considered as an environmental risk to health worldwide. Current evidence is mostly from Western populations exposed to lower levels of pollutants. This study was to explore the association of type 2 diabetes (T2D) and hypertension prevalence with exposure to high levels of air pollution in Iranian adults. The air pollution data were obtained from the air quality monitoring stations of five large cities in Iran from 2006 to 2011. The air quality monitoring stations could only detect ambient particulate matter_10 (PM10) during the study period; therefore, the average PM10 concentration was considered for comparison...
November 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29098478/persistent-organic-pollutants-as-risk-factors-for-obesity-and-diabetes
#8
REVIEW
Chunxue Yang, Alice Pik Shan Kong, Zongwei Cai, Arthur C K Chung
PURPOSE OF REVIEW: The rising prevalence of obesity and diabetes cannot be fully explained by known risk factors, such as unhealthy diet, a sedentary lifestyle, and family history. This review summarizes the available studies linking persistent organic pollutants (POPs) to obesity and diabetes and discusses plausible underlying mechanisms. RECENT FINDINGS: Increasing evidence suggest that POPs may act as obesogens and diabetogens to promote the development of obesity and diabetes and induce metabolic dysfunction...
November 2, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/29073289/pm10-concentration-and-microbiological-assessment-of-air-in-relation-to-the-number-of-acute-cases-of-type-1-diabetes-mellitus-in-the-lubelskie-voivodeship-preliminary-report
#9
Małgorzata Michalska, Maria Bartoszewicz, Piotr Wąż, Sylwia Kozaczuk, Iwona Beń-Skowronek, Katarzyna Zorena
INTRODUCTION: The aim of our study was to evaluate the relation between the concentration of particulate matter of less than 10 μm in diameter (PM10) in air and the effect of psychrophilic bacteria, mesophilic bacteria and mould fungi on the number of new cases of type 1 diabetes mellitus in children and adolescents in the Lubelskie Voivodeship in the years 2015-2016. PATIENTS AND METHODS: Epidemiological data on the number of new cases of T1DM was obtained from the Department of Paediatric Endocrinology and Diabetology of the Medical University in Lublin...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29028277/associations-between-daily-cooking-duration-and-the-prevalence-of-diabetes-and-pre-diabetes-in-a-middle-aged-and-elderly-chinese-population-a-cross-sectional-study
#10
Fei Wang, Jing Wang, Yaru Li, Xu Han, Hua Hu, Caizheng Yu, Jing Yuan, Ping Yao, Xiaoping Miao, Sheng Wei, Youjie Wang, Weihong Chen, Yuan Liang, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Experimental and epidemiological studies indicated that ambient air pollution was positively associated with diabetes. Few studies investigated the associations between household air pollution, for example, daily cooking duration and diabetes or prediabetes. We conducted a cross-sectional study to investigate the associations of daily cooking duration with the prevalence of diabetes and prediabetes among a middle-aged and elderly population. A total of 26,089 individuals (11,250 males and 14,839 females) derived from the Dongfeng-Tongji cohort study were included...
October 13, 2017: Indoor Air
https://www.readbyqxmd.com/read/29016628/hazardous-air-pollutants-and-primary-liver-cancer-in-texas
#11
Luca Cicalese, Giuseppe Curcuru, Mauro Montalbano, Ali Shirafkan, Jeremias Georgiadis, Cristiana Rastellini
The incidence of hepatocellular carcinoma (HCC), the most common primary liver cancer, is increasing in the US and tripled during the past two decades. The reasons for such phenomenon remain poorly understood. Texas is among continental states with the highest incidence of liver cancer with an annual increment of 5.7%. Established risk factors for HCC include Hepatitis B and C (HBV, HCV) viral infection, alcohol, tobacco and suspected risk factors include obesity and diabetes. While distribution of these risk factors in the state of Texas is similar to the national data and homogeneous, the incidence of HCC in this state is exceptionally higher than the national average and appears to be dishomogeneous in various areas of the state suggesting that other non-recognized risk factors might play a role...
2017: PloS One
https://www.readbyqxmd.com/read/28989700/toxicological-implications-of-mitochondrial-localization-of-cyp2e1
#12
Jessica H Hartman, Grover P Miller, Joel N Meyer
Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Therefore, it is unsurprising that it has been the subject of decades of research publications and reviews. However, while CYP2E1 has historically been studied in the endoplasmic reticulum (erCYP2E1), active CYP2E1 is also present in mitochondria (mtCYP2E1). Relatively few studies have specifically focused on mtCYP2E1, but there is growing interest in this form of the enzyme as a driver in toxicological mechanisms given its activity and location...
2017: Toxicology Research
https://www.readbyqxmd.com/read/28976899/community-noise-exposure-and-its-effect-on-blood-pressure-and-renal-function-in-patients-with-hypertension-and-cardiovascular-disease
#13
Angel M Dzhambov, Mariya P Tokmakova, Penka D Gatseva, Nikolai G Zdravkov, Dolina G Gencheva, Nevena G Ivanova, Krasimir I Karastanev, Stefka V Vladeva, Aleksandar T Donchev, Svetlan M Dermendzhiev
BACKGROUND: Road traffic noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD. AIM: This study aimed to explore the effect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province. MATERIALS AND METHODS: We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March - May 2016)...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28975503/the-environmental-pollutant-polychlorinated-biphenyls-and-cardiovascular-disease-a-potential-target-for-antioxidant-nanotherapeutics
#14
REVIEW
Prachi Gupta, Brendan L Thompson, Banrida Wahlang, Carolyn T Jordan, J Zach Hilt, Bernhard Hennig, Thomas Dziubla
Despite production having stopped in the 1970s, polychlorinated biphenyls (PCBs) represent persistent organic pollutants that continue to pose a serious human health risk. Exposure to PCBs has been linked to chronic inflammatory diseases, such as cardiovascular disease, type 2 diabetes, obesity, as well as hepatic disorders, endocrine dysfunction, neurological deficits, and many others. This is further complicated by the PCB's strong hydrophobicity, resulting in their ability to accumulate up the food chain and to be stored in fat deposits...
October 3, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28974480/plasma-concentrations-of-per-and-polyfluoroalkyl-substances-at-baseline-and-associations-with-glycemic-indicators-and-diabetes-incidence-among-high-risk-adults-in-the-diabetes-prevention-program-trial
#15
RANDOMIZED CONTROLLED TRIAL
Andres Cardenas, Diane R Gold, Russ Hauser, Ken P Kleinman, Marie-France Hivert, Antonia M Calafat, Xiaoyun Ye, Thomas F Webster, Edward S Horton, Emily Oken
BACKGROUND: Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results. OBJECTIVE: We sought to examine associations between plasma PFAS concentrations, glycemic indicators, and diabetes incidence among high-risk adults. METHODS: Within the Diabetes Prevention Program (DPP), a trial for the prevention of type 2 diabetes among high-risk individuals, we quantified baseline plasma concentrations of nine PFAS among 957 participants randomized to a lifestyle intervention or placebo...
October 2, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28953453/long-term-exposure-to-road-traffic-noise-and-nitrogen-dioxide-and-risk-of-heart-failure-a-cohort-study
#16
Mette Sørensen, Olav Wendelboe Nielsen, Ahmad Sajadieh, Matthias Ketzel, Anne Tjønneland, Kim Overvad, Ole Raaschou-Nielsen
BACKGROUND: Although air pollution and road traffic noise have been associated with higher risk of cardiovascular diseases, associations with heart failure have received only little attention. OBJECTIVES: We aimed to investigate whether long-term exposure to road traffic noise and nitrogen dioxide (NO2) were associated with incident heart failure. METHODS: In a cohort of 57,053 people 50-64 y of age at enrollment in the period 1993-1997, we identified 2,550 cases of first-ever hospital admission for heart failure during a mean follow-up time of 13...
September 26, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28952002/south-asian-health-inflammation-infection-exposure-and-the-human-microbiome
#17
Jennifer Leng, Ponni Peruluswami, Sehrish Bari, Sunanda Gaur, Farshid Radparvar, Faruque Parvez, Yu Chen, Cristina Flores, Francesca Gany
This paper presents the results of the literature review conducted for the working group topic on inflammation, infection, exposure, and the human microbiome. Infection and chronic inflammation can elevate risk for cardiovascular disease and cancer. Environmental exposures common among South Asian (SA) subgroups, such as arsenic exposure among Bangladeshis and particulate matter air pollution among taxi drivers, also pose risks. This review explores the effects of exposure to arsenic and particulate matter, as well as other infections common among SAs, including human papillomavirus (HPV) and hepatitis B/C infection...
September 27, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28936425/gut-dysbiosis-in-animals-due-to-environmental-chemical-exposures
#18
REVIEW
Cheryl S Rosenfeld
The gut microbiome consists of over 10(3)-10(4) microorganism inhabitants that together possess 150 times more genes that the human genome and thus should be considered an "organ" in of itself. Such communities of bacteria are in dynamic flux and susceptible to changes in host environment and body condition. In turn, gut microbiome disturbances can affect health status of the host. Gut dysbiosis might result in obesity, diabetes, gastrointestinal, immunological, and neurobehavioral disorders. Such host diseases can originate due to shifts in microbiota favoring more pathogenic species that produce various virulence factors, such as lipopolysaccharide...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28934721/association-of-long-term-exposure-to-transportation-noise-and-traffic-related-air-pollution-with-the-incidence-of-diabetes-a-prospective-cohort-study
#19
Charlotte Clark, Hind Sbihi, Lillian Tamburic, Michael Brauer, Lawrence D Frank, Hugh W Davies
BACKGROUND: Evidence for an association between transportation noise and cardiovascular disease has increased; however, few studies have examined metabolic outcomes such as diabetes or accounted for environmental coexposures such as air pollution, greenness, or walkability. OBJECTIVES: Because diabetes prevalence is increasing and may be on the causal pathway between noise and cardiovascular disease, we examined the influence of long-term residential transportation noise exposure and traffic-related air pollution on the incidence of diabetes using a population-based cohort in British Columbia, Canada...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28917207/exposure-to-ambient-air-pollution-and-the-incidence-of-dementia-a-population-based-cohort-study
#20
Hong Chen, Jeffrey C Kwong, Ray Copes, Perry Hystad, Aaron van Donkelaar, Karen Tu, Jeffrey R Brook, Mark S Goldberg, Randall V Martin, Brian J Murray, Andrew S Wilton, Alexander Kopp, Richard T Burnett
INTRODUCTION: Emerging studies have implicated air pollution in the neurodegenerative processes. Less is known about the influence of air pollution, especially at the relatively low levels, on developing dementia. We conducted a population-based cohort study in Ontario, Canada, where the concentrations of pollutants are among the lowest in the world, to assess whether air pollution exposure is associated with incident dementia. METHODS: The study population comprised all Ontario residents who, on 1 April 2001, were 55-85years old, Canadian-born, and free of physician-diagnosed dementia (~2...
September 13, 2017: Environment International
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