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https://www.readbyqxmd.com/read/28219830/gut-microbiome-based-medical-methodologies-for-early-stage-disease-prevention
#1
REVIEW
Jing-Zhang Wang, Wen-Tao Du, Yan-Li Xu, Shu-Zhen Cheng, Zhi-Jun Liu
Recent advancements highlight the important role of gut microbiome in human health. However, a variety of endogenous and exogenous factors, such as genes, foods, drugs, environmental pollutions, oxidative stress, etc., may interfere with the gut microbiome in vivo and increase risks of digestive system diseases, cardiovascular diseases, neurological diseases, obesity, diabetes, cancers, and so on. Abundant discoveries listed in this work support that changes in the composition of the gut microbiome may be potentially used as sensitive early-stage diagnostic biomarkers and that the gut microbiome could be a promising therapeutic target for systemic prevention of multiple human diseases...
February 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28212639/erectile-dysfunction-and-exposure-to-ambient-air-pollution-in-a-nationally-representative-cohort-of-older-men
#2
Lindsay A Tallon, Justin Manjourides, Vivian C Pun, Murray A Mittleman, Marianthi-Anna Kioumourtzoglou, Brent Coull, Helen Suh
BACKGROUND: Little is known about the association between air pollution and erectile dysfunction (ED), a disorder occurring in 64% of men over the age of 70, and to date, no studies have been published. To address this significant knowledge gap, we explored the relationship between ED and air pollution in a group of older men who were part of the National Social Life, Health, and Aging Project (NSHAP), a nationally representative cohort study of older Americans. METHODS: We obtained incident ED status and participant data for 412 men (age 57-85)...
February 17, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28202225/persistent-organic-pollutants-and-diabetes-among-inuit-in-the-canadian-arctic
#3
Kavita Singh, Hing Man Chan
Type 2 diabetes is a chronic metabolic disease that is of increasing concern in Inuit communities. Behavioural factors such as physical inactivity and poor diet are well-known risk factors. Exposure to persistent organic pollutants (POPs) has emerged as an additional factor in the pathogenesis of diabetes. In this study, association between polychlorinated biphenyls (PCBs) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with diabetes in Canadian Inuit was examined. Data from the Adult Inuit Health Survey (2007-2008) of Inuit participants from the Canadian Arctic were analyzed...
February 12, 2017: Environment International
https://www.readbyqxmd.com/read/28154098/stroke-risk-factors-genetics-and-prevention
#4
Amelia K Boehme, Charles Esenwa, Mitchell S V Elkind
Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as modifiable and nonmodifiable. Age, sex, and race/ethnicity are nonmodifiable risk factors for both ischemic and hemorrhagic stroke, while hypertension, smoking, diet, and physical inactivity are among some of the more commonly reported modifiable risk factors. More recently described risk factors and triggers of stroke include inflammatory disorders, infection, pollution, and cardiac atrial disorders independent of atrial fibrillation...
February 3, 2017: Circulation Research
https://www.readbyqxmd.com/read/28153529/ambient-ozone-and-incident-diabetes-a-prospective-analysis-in-a-large-cohort-of-african-american-women
#5
Michael Jerrett, Robert Brook, Laura F White, Richard T Burnett, Jeffrey Yu, Jason Su, Edmund Seto, Julian Marshall, Julie R Palmer, Lynn Rosenberg, Patricia F Coogan
BACKGROUND: Ozone is a ubiquitous air pollutant with increasing concentrations in many populous regions. Toxicological studies show that ozone can cause oxidative stress and increase insulin resistance. These pathways may contribute to metabolic changes and diabetes formation. In this paper, we investigate the association between ozone and incident type 2 diabetes in a large cohort of African American women. METHODS: We used Cox proportional hazards models to calculate hazard ratios (HRs) for incident type 2 diabetes associated with exposure to ozone in a cohort of 45,231 African American women living in 56 metropolitan areas across the United States...
January 30, 2017: Environment International
https://www.readbyqxmd.com/read/28137791/longitudinal-associations-between-ambient-air-pollution-with-insulin-sensitivity-%C3%AE-cell-function-and-adiposity-in-los-angeles-latino-children
#6
Tanya L Alderete, Rima Habre, Claudia M Toledo-Corral, Kiros Berhane, Zhanghua Chen, Frederick W Lurmann, Marc J Weigensberg, Michael I Goran, Frank D Gilliland
Evidence suggests that ambient air pollution (AAP) exposure may contribute to the development of obesity and type 2 diabetes. The objective of this study was to determine whether exposure to elevated concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameter less than 2.5 (PM2.5) had adverse effects on longitudinal measures of insulin sensitivity, β-cell function, and obesity in children at high risk for developing diabetes. Overweight and obese Latino children (8-15 years; n=314) were enrolled between 2001-2012 from Los Angeles, California and followed for an average of 3...
January 30, 2017: Diabetes
https://www.readbyqxmd.com/read/28131481/association-of-polycyclic-aromatic-hydrocarbons-metabolites-and-risk-of-diabetes-in-coke-oven-workers
#7
Liangle Yang, Kai Yan, Dan Zeng, Xuefeng Lai, Xuguang Chen, Qin Fang, Huan Guo, Tangchun Wu, Xiaomin Zhang
Elevated polycyclic aromatic hydrocarbons (PAHs) metabolites have recently been linked to increased risk of diabetes in the general population, but little is known about the risk of diabetes due to high pollution levels of PAHs exposure. We aimed to examine whether occupational exposure to PAHs would be one of the important risk factors for diabetes in the coke oven workers. A total of 1472 coke oven workers with complete data were qualified for the present study. We measured 12 urinary monohydroxy polycyclic aromatic hydrocarbons (OH-PAHs) by gas chromatography-mass spectrometry (GC-MS)...
January 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28129617/computational-study-involving-identification-of-endocrine-disrupting-potential-of-herbicides-its-implication-in-tds-and-cancer-progression-in-crpc-patients
#8
Md Irshad Ahmad, Afia Usman, Masood Ahmad
Several environmental pollutants, including herbicides, act as endocrine disrupting chemicals (EDCs). They can cause cancer, diabetes, obesity, metabolic diseases and developmental problems. Present study was conducted to screen 608 herbicides for evaluating their endocrine disrupting potential. The screening was carried out with the help of endocrine disruptome docking program, http://endocrinedisruptome.ki.si (Kolsek et al., 2013). This program screens the binding affinity of test ligands to 12 major nuclear receptors...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28112071/early-life-programming-and-the-risk-of-non-alcoholic-fatty-liver-disease
#9
C Lynch, C S Chan, A J Drake
Non-alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, type 2 diabetes and cardiovascular disease and can be considered the hepatic manifestation of the metabolic syndrome. NAFLD represents a spectrum of disease, from the relatively benign simple steatosis to the more serious non-alcoholic steatohepatitis, which can progress to liver cirrhosis, hepatocellular carcinoma and end-stage liver failure, necessitating liver transplantation. Although the increasing prevalence of NAFLD in developed countries has substantial implications for public health, many of the precise mechanisms accounting for the development and progression of NAFLD are unclear...
January 23, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28095285/urine-levels-of-phthalate-metabolites-and-bisphenol-a-in-relation-to-main-metabolic-syndrome-components-dyslipidemia-hypertension-and-type-2-diabetes-a-pilot-study
#10
Roman Piecha, Štěpán Svačina, Marek Malý, Karel Vrbík, Zdenka Lacinová, Martin Haluzík, Jana Pavloušková, Adam Vavrouš, Dagmar Matějková, Dana Müllerová, Miloš Mráz, Martin Matoulek
AIM: Human exposure to organic pollutants (some of them also called endocrine disruptors) can be associated with adverse metabolic health outcomes including type 2 diabetes. The goal of this study was to compare the urine levels of bisphenol A and phthalate metabolites in subgroups of patients with metabolic syndrome composed of patients with and without three important components of metabolic syndrome (hypertension, dyslipidemia and diabetes). METHODS: We have investigated 24 hr urine samples of 168 patients with metabolic syndrome from the Metabolic Outpatient Department of General University Hospital in Prague...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28076319/impact-of-nutrition-on-pollutant-toxicity-an-update-with-new-insights-into-epigenetic-regulation
#11
Jessie B Hoffman, Michael C Petriello, Bernhard Hennig
Exposure to environmental pollutants is a global health problem and is associated with the development of many chronic diseases, including cardiovascular disease, diabetes and metabolic syndrome. There is a growing body of evidence that nutrition can both positively and negatively modulate the toxic effects of pollutant exposure. Diets high in proinflammatory fats, such as linoleic acid, can exacerbate pollutant toxicity, whereas diets rich in bioactive and anti-inflammatory food components, including omega-3 fatty acids and polyphenols, can attenuate toxicant-associated inflammation...
January 11, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28063597/living-near-major-roads-and-the-incidence-of-dementia-parkinson-s-disease-and-multiple-sclerosis-a-population-based-cohort-study
#12
Hong Chen, Jeffrey C Kwong, Ray Copes, Karen Tu, Paul J Villeneuve, Aaron van Donkelaar, Perry Hystad, Randall V Martin, Brian J Murray, Barry Jessiman, Andrew S Wilton, Alexander Kopp, Richard T Burnett
BACKGROUND: Emerging evidence suggests that living near major roads might adversely affect cognition. However, little is known about its relationship with the incidence of dementia, Parkinson's disease, and multiple sclerosis. We aimed to investigate the association between residential proximity to major roadways and the incidence of these three neurological diseases in Ontario, Canada. METHODS: In this population-based cohort study, we assembled two population-based cohorts including all adults aged 20-50 years (about 4·4 million; multiple sclerosis cohort) and all adults aged 55-85 years (about 2·2 million; dementia or Parkinson's disease cohort) who resided in Ontario, Canada on April 1, 2001...
January 4, 2017: Lancet
https://www.readbyqxmd.com/read/28054921/evaluation-of-the-effects-of-air-pollutants-on-diabetic-wounds
#13
Young Suk Choi, Il-Hoon Sung, Ji Yun Lim, A Hyun Kyun, Eui Dong Yeo, Sun Geun Lee, Young Koo Lee
BACKGROUND: Although air pollution containing fine dust particles is gaining attention worldwide, little is known about the effects of such pollutants on diabetic wounds. Air pollutants from diesel exhaust particles (DEPs) cause inflammation, resulting in an increased expression of pro-inflammatory cytokines and chemo- kines, which attract monocytes and T cells to the sites of inflamma- tion. The authors evaluated the effects of air pollutants on diabetic wounds. MATERIALS AND METHODS: Fibroblast cells were derived from streptozotocin-induced diabetic rats...
December 29, 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28025522/residential-proximity-to-major-roadways-and-risk-of-type-2-diabetes-mellitus-a-meta-analysis
#14
Zhiqing Zhao, Faying Lin, Bennett Wang, Yihai Cao, Xu Hou, Yangang Wang
Research indicates that higher levels of traffic-related pollution exposure increase the risk of diabetes, but the association between road proximity and diabetes risk remains unclear. To assess and quantify the association between residential proximity to major roadways and type 2 diabetes, a systematic review and meta-analysis was performed. Embase, Medline, and Web of Science were searched for eligible studies. Using a random-effects meta-analysis, the summary relative risks (RRs) were calculated. Bayesian meta-analysis was also performed...
December 22, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28025108/di-2-ethylhexyl-phthalate-could-disrupt-the-insulin-signaling-pathway-in-liver-of-sd-rats-and-l02-cells-via-ppar%C3%AE
#15
Wang Zhang, Xin-Yue Shen, Wen-Wen Zhang, Hao Chen, Wei-Ping Xu, Wei Wei
Di-(2-ethylhexyl)-phthalate (DEHP), a ubiquitous industrial pollutant in our daily life, has been reported to cause adverse effects on glucose homeostasis and insulin sensitivity in epidemiological studies previously. Recently, it has been reported to be an endocrine disrupter and ligand to peroxisome proliferator activated receptor, which could influence the homeostasis of liver metabolic systems and contribute to the development of type-2 diabetes. However, the potential mechanisms are not known yet. This study was designed to solve these problems with male SD rats and normal human hepatocyte line, L02 cells, exposed to DEHP for toxicological experiments...
December 23, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28011135/hypertension-diabetes-and-lifestyle-in-the-long-term-results-from-a-swiss-population-based-cohort
#16
Diana Walther, Ivan Curjuric, Julia Dratva, Emmanuel Schaffner, Carlos Quinto, Arno Schmidt-Trucksäss, Ikenna C Eze, Luc Burdet, Marco Pons, Margaret W Gerbase, Medea Imboden, Christian Schindler, Nicole Probst-Hensch
Healthy lifestyles are integral in preventing and treating common cardiovascular and metabolic diseases. The aim of this study was to observe smoking habits, alcohol intake, physical activity and body mass index over a 10-year period in a population-based cohort, particularly focusing on participants with hypertension and type 2 diabetes mellitus. Included were 4155 participants from the first (2001-2003) and second (2010-2011) follow-ups of the Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults (SAPALDIA)...
December 21, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/28001123/fine-scale-spatial-and-temporal-variation-in-temperature-and-arrhythmia-episodes-in-the-va-normative-aging-study
#17
Antonella Zanobetti, Brent A Coull, Itai Kloog, David Sparrow, Pantel S Vokonas, Diane R Gold, Joel Schwartz
: Many studies have demonstrated that cold and hot temperatures are associated with increased deaths and hospitalization rates; new findings indicate also an association with more specific cardiac risk factors. Most of these existing studies have relied on few weather stations to characterize exposures; few have used residence-specific estimates of temperature, or examined the exposure-response function. We investigated the association of arrhythmia episodes with spatial and temporal variation in temperature...
January 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/27990700/biomass-fuel-smoke-exposure-was-associated-with-adverse-cardiac-remodeling-and-left-ventricular-dysfunction-in-peru
#18
Melissa S Burroughs Peña, Eric J Velazquez, Jose D Rivera, Fawaz Alenezi, Catherine Wong, Matthew Grigsby, Victor G Davila-Roman, Robert H Gilman, Jaime J Miranda, William Checkley
BACKGROUND: While household air pollution from biomass fuel combustion has been linked to cardiovascular disease, the effects on cardiac structure and function have not been well described. We sought to determine the association between biomass fuel smoke exposure and cardiac structure and function by transthoracic echocardiography. METHODS: We identified a random sample of urban and rural residents living in the high-altitude region of Puno, Peru. Daily biomass fuel use was self-reported...
December 19, 2016: Indoor Air
https://www.readbyqxmd.com/read/27968831/mortality-as-a-function-of-dust-haze-in-china-a-multi-city-time-series-study
#19
Jun Yang, Maigeng Zhou, Peng Yin, Mengmeng Li, Chun-Quan Ou, Shaohua Gu, Qiyong Liu
BACKGROUND: In recent years, hazardous dust-hazehas become one of the most catastrophic weather events in China. Reliable estimation of the burden of dust-haze on health has implications for implementation of mitigation measures. We did a time-series study to examine the health effects of dust-haze in China. METHODS: A dust-haze day was defined ashaving daily visibility of less than 10 km, no rainfall, and relative humidity of less than 80%. A two-stage analysis was used to assess the effect of dust-haze on city-specific, cause-specific, sex-specific, and age-specific mortality in ten Chinese provincial capitals...
October 2016: Lancet
https://www.readbyqxmd.com/read/27923100/effects-of-air-pollution-exposure-on-glucose-metabolism-in-los-angeles-minority-children
#20
C M Toledo-Corral, T L Alderete, R Habre, K Berhane, F W Lurmann, M J Weigensberg, M I Goran, F D Gilliland
OBJECTIVES: Growing evidence indicates that ambient (AAP: NO2 , PM2.5 and O3 ) and traffic-related air pollutants (TRAP) contribute to metabolic disease risk in adults; however, few studies have examined these relationships in children. METHODS: Metabolic profiling was performed in 429 overweight and obese African-American and Latino youth living in urban Los Angeles, California. This cross-sectional study estimated individual residential air pollution exposure and used linear regression to examine relationships between air pollution and metabolic outcomes...
December 6, 2016: Pediatric Obesity
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