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Sean M McNary, Nasser Heyrani, Ido Volk, Robert M Szabo, Christopher O Bayne
PURPOSE: To determine the effects of motion-increasing modifications to radioscapholunate (RSL) arthrodesis on capitolunate contact pressure in cadaveric wrist specimens. METHODS: Ten fresh-frozen cadaveric wrists were dissected of all superficial soft tissue, potted in polymethyl-methacrylate, and the carpus exposed via a ligament-sparing capsulotomy. An RSL arthrodesis was simulated using 2 2.4-mm distal radius plates with locking screws. The distal scaphoid pole and triquetrum were removed with an osteotome and rongeur, respectively...
September 18, 2018: Journal of Hand Surgery
Jörg Hänze, Peter Rexin, Peter Jakubowski, Henner Schreiber, Hendrik Heers, Susanne Lingelbach, Ralf Kinscherf, Eberhard Weihe, Rainer Hofmann, Axel Hegele
Innervation of prostate cancer (CaP) tissue favors tumor progression and metastasis but the regulation of innervation in CaP is unclear. The oncogenic transcription factor ERG is commonly induced by a typical TMPRSS2-ERG (TE) gene fusion in CaP and may affect innervation. Here, we analyzed whether nerve density of CaP tissue is related to TE status or perineural infiltration status of CaP tissue. In parallel, we measured several members of the neuropilin/plexin/semaphorin family (NRP, PLXN, and SEMA) as possible targets mediating innervation...
September 18, 2018: Urologic Oncology
Jinbao Li, Rui Cheng, Huijuan Xiu, Meiyun Zhang, Qiang Liu, Te Song, Huiling Dong, Bin Yao, Xuefei Zhang, Evguenii Kozliak, Yun Ji
Nanofibrillated cellulose (NFC)-based foam materials have broad prospects in replacing traditional foams, due to its facile natural biodegradation. This study addressed the relationship between the foam preparation process parameters and resulting pore structure. An aqueous NFC suspension was freeze-dried while adding an organic solvent, ethanol, to adjust the curing process. The effects of the solid content and freeze-drying temperature on the microstructure and mechanical stability as well as heat transfer performance of the produced NFC-based foam were investigated...
December 1, 2018: Carbohydrate Polymers
Francisco J Segovia, Gádor Indra Hidalgo, Juliana Villasante, Xavier Ramis, María Pilar Almajano
Increasingly, consumers want products containing little or no synthetic compounds. Avocado seeds, which are a residue of the food industry, could be used to obtain extracts with high antioxidant power. In the present study, the most popular radical scavenging methods are presented, establishing a comparison between them, besides working with two different extractions: pure methanol and ethanol⁻water (50:50 v/v ). The radical scavenging assay methods ORAC and ABTS were performed, as well as a novel method: the reaction to methoxy radical, as determined by electron paramagnetic resonance (EPR)...
September 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Chia-Jung Li, San-Nung Chen, Li-Te Lin, Chyi-Uei Chern, Peng-Hui Wang, Zhi-Hong Wen, Kuan-Hao Tsui
Mitochondrial dysfunction is related to reproductive decline in humans, with consequences for in vitro fertilization (IVF). We assessed whether dehydroepiandrosterone (DHEA) could regulate mitochondrial homeostasis and mitophagy of cumulus cells (CCs) in poor ovarian responders (PORs). A total of 66 women who underwent IVF treatment at the Reproductive Medicine Center of Kaohsiung Veterans General Hospital were included in this study. Twenty-eight normal ovarian responders (NOR) and 38 PORs were enrolled. PORs were assigned to receive DHEA supplementation ( n = 19) or not ( n = 19) before IVF cycles...
September 20, 2018: Journal of Clinical Medicine
Jun-Ya Okamura, Koki Uemura, Shintaro Saruwatari, Gang Wang
The inferotemporal cortex consists of an anterior (cytoarchitectonic area TE) and a posterior (area TEO) part, which together constitute the final areas of the ventral visual stream, which is critical for object discrimination. Area TE receives dense projections from area TEO. We have previously identified a response tolerance in the cells in area TE in monkeys to a range of viewing angles after object discrimination at each of several views. To investigate the contribution of area TEO to the establishment of such a response tolerance in area TE, we conducted electrophysiological recordings of the responses of the single cells in area TEO after performance saturation of object discrimination at several independent views, without any association across views, and compared them with those obtained from the TE cells...
September 21, 2018: European Journal of Neuroscience
Konstantinos Konstantinou, Felix Cosmin Mocanu, Tae Hoon Lee, Steve R Elliott
Ion irradiation corresponds to a process that involves the production of non-equilibrium cascades in the host material, and the atomistic modelling of such events in glasses is challenging. Here, non-equilibrium cascades in amorphous Ge<sub>2</sub>Sb<sub>2</sub>Te<sub>5</sub> phase-change memory material have been investigated by means of first-principles molecular-dynamics simulations. A stochastic boundary-conditions approach is employed to treat the thermal nature of the cascades and drive the modelled system back to equilibrium in a natural way, while four different initial thermal-spike energies are considered...
September 21, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Shaoyou Qin, Song Wang, Xu Wang, Jiangbin Wang
BACKGROUND: This study was designed to determine the diagnostic value of liver stiffness measured by transient elastography (TE) in identifying chronic kidney disease (CKD) in individuals with ultrasonography-diagnosed NAFLD. METHODS: A total of 1439 adult patients with ultrasonography-diagnosed NAFLD between October 2015 and August 2017 in China-Japan union hospital of Jilin university were initially eligible. According to the exclusion criteria, 24 patients were excluded, and eventually, a total of 1415 patients were included in the study...
September 21, 2018: Journal of Clinical Laboratory Analysis
Cen-Feng Fu, Jiuyu Sun, Qiquan Luo, Xingxing Li, Wei Hu, Jinlong Yang
Two-dimensional (2D) materials with the vertical intrinsic electric fields show great promise in inhibiting the recombination of photo-generated carriers and widening light absorption region for the photocatalytic applications. For the first time, we investigated the potential feasibility of experimentally attainable 2D M2 X3 (M = Al, Ga, In; X = S, Se, Te) family featuring out-of-plane ferroelectricity used in photocatalytic water splitting. By using first-principles calculations, all the nine members of 2D M2 X3 are verified to be available photocatalysts for overall water splitting...
September 21, 2018: Nano Letters
Gabriela López-Angulo, Julio Montes-Avila, Leticia Sánchez-Ximello, Sylvia P Díaz-Camacho, Valentín Miranda-Soto, José A López-Valenzuela, Francisco Delgado-Vargas
Red arils of Pithecellobium dulce fruit, commonly known as guamuchil, show high antioxidant (AOx) and α-glucosidase inhibitory (IαG) activities, which have been mainly associated with the content of unknown anthocyanins. In this study, the AOx (i.e., DPPH and ABTS as Trolox equivalents, μmol TE/g) and IαG (as half-maximal inhibitory concentration, IC50 , mg/mL) activities of the anthocyanin-rich fraction (ARF) obtained from red arils were contrasted with those of the methanol extract (ME), and the main ARF anthocyanins were characterized by HPLC-DAD-ESI-MS, GC-MS and 1 H-NMR...
September 20, 2018: Plant Foods for Human Nutrition
Hannah M Lee, Joseph Ahn, W Ray Kim, Joseph K Lim, Mindie Nguyen, Calvin Q Pan, Donghee Kim, Ajitha Mannalithara, Helen Te, Huy Trinh, Danny Chu, Tram Tran, Jocelyn Woog, Anna S Lok
BACKGROUND AND AIMS: The management of chronic hepatitis B patients is not well characterized in real-world practice. We compared baseline characteristics of CHB patients on entecavir, the frequency of on-treatment monitoring, and the effectiveness of ETV treatment between academic and community practices. METHODS: Treatment-naïve CHB patients ≥18 years old, treated with ETV for ≥12 months from 2005 to 2013, in 26 community and academic practices throughout the USA were retrospectively evaluated...
September 20, 2018: Digestive Diseases and Sciences
Ziad Simon Fawaz, Suzanne Kazandjian, James M Tsui, Dr Slobodan Devic, Magali Lecavalier-Barsoum, Te Vuong, Sara Elakshar, Aurelie Garant, Isabelle Lavoie, Tamin M Niazi
Background Esophageal cancer treatment requires large radiation fields due to the deep location of the esophagus in the mediastinum and the high incidence of radial spread. There is no optimal radiation technique to ensure appropriate target coverage and minimal dose to all normal structures. Methods Fifteen consecutive cases of locally advanced esophageal cancer treated with radical chemoradiation (CRT) were analyzed. The total prescribed dose was 50.4 Gy in 28 fractions. A total of 60 plans were generated for analysis, including four different methods for each case...
July 16, 2018: Curēus
Yishul Wei, Jennifer R Ramautar, Michele A Colombo, Bart H W Te Lindert, Eus J W Van Someren
People with Insomnia Disorder (ID) not only experience abundant nocturnal mentation, but also report altered spontaneous mental content during daytime wakefulness, such as an increase in bodily experiences (heightened somatic awareness). Previous studies have shown that resting-state EEG can be temporally partitioned into quasi-stable microstates, and that these microstates form a small number of canonical classes that are consistent across people. Furthermore, the microstate classes have been associated with individual differences in resting mental content including somatic awareness...
2018: Frontiers in Psychiatry
Flávia Alvim Sant'Anna Addor, Ludmila Coelho Donato, Camila Sirieiro Abreu Melo
Purpose: Telogen effluvium (TE) is defined as a diffuse hair loss characterized by shortening of the anagen phase and precipitation of the telogen phase, with a consequent reduction of total hair volume. Nutritional supplementation is indicated under conditions in which TE is related to dietary disorders. The aim of this clinical study was to compare the efficacy of two different supplements in monotherapy for TE. Patients and methods: Female adult patients were randomized to receive two oral nutritional supplements (group 1: a supplement composed of zinc, biotin, iron, vitamins A, C, E, and B complex, folic acid, magnesium, and amino acids of keratin and collagen and group 2: calcium pantothenate cystine, thiamine nitrate, medicinal yeast, keratin, and aminobenzoic acid) to treat hair loss for 180 days...
2018: Clinical, Cosmetic and Investigational Dermatology
Oleh Y Yermakov, Dmitry V Permyakov, Filipp V Porubaev, Pavel A Dmitriev, Anton K Samusev, Ivan V Iorsh, Radu Malureanu, Andrei V Lavrinenko, Andrey A Bogdanov
Metasurfaces offer great potential to control near- and far-fields through engineering optical properties of elementary cells or meta-atoms. Such perspective opens a route to efficient manipulation of the optical signals both at nanoscale and in photonics applications. In this paper we show that a local surface conductivity tensor well describes optical properties of a resonant plasmonic hyperbolic metasurface both in the far-field and in the near-field regimes, where spatial dispersion usually plays a crucial role...
September 20, 2018: Scientific Reports
Huey-En Tzeng, Chih-Hsin Tang, Sz-Hua Wu, Hsien-Te Chen, Yi-Chin Fong, Yung-Chang Lu, Wei-Cheng Chen, Hsien-Da Huang, Chih-Yang Lin, Shih-Wei Wang
Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. WNT1-inducible signaling pathway protein-3 (WISP-3, also termed CCN6) belongs to the CCN family of proteins and is implicated in the regulation of various cellular functions, such as cell proliferation, differentiation, and migration. It is unknown as to whether CCN6 affects human chondrosarcoma metastasis. We show how CCN6 promotes chondrosarcoma cell migration and invasion via matrix metallopeptidase-9 (MMP)-9 expression. These effects were abolished by pretreatment of chondrosarcoma cells with PI3K, Akt, mTOR, and NF-κB inhibitors or short interfering (si)RNAs...
September 20, 2018: Cell Death & Disease
Can Altınelataman, Olga Koroleva, Tatyana Fedorova, Anna Torkova, Ksenia Lisitskaya, Mikhail Tsentalovich, Aleksey Kononikhin, Igor Popov, Daria Vasina, Leonid Kovalyov, Ufuk Çelik
European seabass (Dicentrarchus labrax, Linnaeus, 1758) (L) and gilthead seabream (Sparus aurata, Linnaeus, 1758) (C) muscles were hydrolysated by Alcalase (Lalc , Calc ) and Chymotrypsin (Lch , Cch ) then hydrolysates were examined and their peptide profiles obtained. A total of 765, 794, 132 and 232 peptides were identified in Calc , Lalc , Cch and Lch , respectively. Although, Lch and Cch were expected to have more antioxidant capacity because of their peptide profiles, Alcalase hydrolysates observed in vitro, were slightly higher (TEAC assay for Calc : 848...
January 15, 2019: Food Chemistry
N Bertheuil, N Isola, D Bergeat, C Mocquard, E Watier, S Rouze, B Meunier
Anastomotic leakage frequently complicates esophagectomy and can trigger a rare life- threatening complication, a tracheoesophageal fistula. No guideline has yet addressed this complication. Plastic surgeons play a crucial role for salvage surgery. When a re-operation is chosen the possibilities of flap interposition depend on how the thoracotomy was initially performed. This study tried to identify key techniques in order help thoracic or general surgeons to preserve all the local flaps available for TEF if it occurs...
September 17, 2018: Annales de Chirurgie Plastique et Esthétique
Amy R Best, Stacey L Halum, Noah P Parker
INTRODUCTION: The aim of this study was to evaluate the current indications for and clinical factors influencing the use of transnasal esophagoscopy (TNE). METHODS: An online survey was sent to American Broncho-Esophagological Association members, including questions on demographics, indications, and factors influencing the use of TNE. RESULTS: Sixty of 251 members (24%) completed the survey. Ninety-three percent of respondents reported academic practices, while 98% practice in medium to large urban settings...
September 21, 2018: Annals of Otology, Rhinology, and Laryngology
Seong Hwan Kim, Dong Wan Kim, Jae Ha Hwang, Kwang Seog Kim, Sam Yong Lee
RATIONALE: Trichoepithelioma (TE) is a rare benign skin tumor that originates from the hair follicle epithelium. Although skin lesions arising from scar tissues are mostly malignant, the development of a benign tumor such as TE is a rare event. PATIENT CONCERNS: A 28-year-old male patient who had a scar on the left cheek which arose 10 years ago because of a chemical burn visited our hospital. Scar revision was performed under local anesthesia. DIAGNOSIS: Histological examination identified the specimen as a TE with malignant foci suspicious of basal cell carcinoma (BCC) at the lateral margin of the specimen...
September 2018: Medicine (Baltimore)
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