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https://www.readbyqxmd.com/read/29164460/di-2-ethylhexyl-phthalate-induces-glucose-metabolic-disorder-in-adolescent-rats
#1
Jin Xu, Liting Zhou, Shuyue Wang, Jian Zhu, Te Liu, Yiyang Jia, Di Sun, Huaiji Chen, Qi Wang, Feng Xu, Yuezhu Zhang, Hongbo Liu, Tianrong Zhang, Lin Ye
As a plasticizer, di-(2-ethylhexyl)-phthalate (DEHP) is widely added in various commercial products. Some researchers had suggested that DEHP has adverse effects on the glucose metabolism, but the mechanisms remain unclear. Adolescent Wistar rats were divided into four groups and administered DEHP by gavage at 0, 5, 50, and 500 mg kg(-1) d(-1) for 28 days. ELISA was used to quantify the serum insulin and leptin levels; RT-PCR, immunohistochemistry, and Western blot were used to detect the mRNA and protein expressions of Janus-activated kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), suppressor of cytokine signaling 3 (SOCS3), leptin receptor (Ob-R), and insulin receptor (IR) in liver and pancreas In comparison to the control group, the DEHP-treated rats showed the following: (1) higher organ coefficient of liver; (2) higher fasting blood glucose levels, higher fasting serum insulin and leptin levels, higher insulin resistance index homeostasis model assessment; (3) lower protein levels of Ob-R and IR in the liver and pancreas; (4) higher protein levels of JAK2 and STAT3 in the liver; and (5) higher protein and mRNA levels of SOCS3 in the liver and pancreas...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29162665/the-beneficial-effects-of-curcumin-in-cirrhotic-rats-with-portal-hypertension
#2
Shao-Jung Hsu, Jing-Yi Lee, Te-Yueh Lin, Yu-Hsin Hsieh, Hui-Chun Huang, Fa-Yauh Lee, Han-Chieh Lin, Ming-Chih Hou, Shou-Dong Lee
In liver cirrhosis with portal hypertension, the uneven distribution of vasoactive substances leads to increased intrahepatic vascular resistance and splanchnic vasodilatation. Angiogenesis also induces increased portal inflow and portosystemic collaterals. The collaterals may induce lethal complications such as gastroesophageal variceal hemorrhage, but the therapeutic effect of vasoconstrictors is still suboptimal due to poor collateral vasoresponsivenss. Curcumin has aroused much attention for its anti-fibrosis, vasoactive and anti-angiogenesis actions...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29161996/computational-screening-of-fatty-acid-synthase-inhibitors-against-thioesterase-domain
#3
Wanwisa Panman, Bodee Nutho, Supakarn Chamni, Supaporn Dokmaisrijan, Nawee Kungwan, Thanyada Rungrotmongkol
Thioesterase (TE) domain of fatty acid synthase (FAS) is an attractive therapeutic target for design and development of anticancer drugs. In this present work, we search for the potential FAS inhibitors of TE domain from the ZINC database based on similarity search using three natural compounds as templates, including flavonoids, terpenoids and phenylpropanoids. Molecular docking was used to predict the interaction energy of each screened ligand compared to the reference compound, which is methyl γ-linolenylfluorophosphonate (MGLFP)...
November 21, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29160952/transit-time-mapping-in-the-mouse-brain-using-time-encoded-pcasl
#4
Lydiane Hirschler, Leon P Munting, Artem Khmelinskii, Wouter M Teeuwisse, Ernst Suidgeest, Jan M Warnking, Louise van der Weerd, Emmanuel L Barbier, Matthias J P van Osch
The cerebral blood flow (CBF) is a potential biomarker for neurological disease. However, the arterial transit time (ATT) of the labeled blood is known to potentially affect CBF quantification. Furthermore, ATT could be an interesting biomarker in itself, as it may reflect underlying macro- and microvascular pathologies. Currently, no optimized magnetic resonance imaging (MRI) sequence exists to measure ATT in mice. Recently, time-encoded labeling schemes have been implemented in rats and humans, enabling ATT mapping with higher signal-to-noise ratio (SNR) and shorter scan time than multi-delay arterial spin labeling (ASL)...
November 21, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29160304/il11-is-a-crucial-determinant-of-cardiovascular-fibrosis
#5
Sebastian Schafer, Sivakumar Viswanathan, Anissa A Widjaja, Wei-Wen Lim, Aida Moreno-Moral, Daniel M DeLaughter, Benjamin Ng, Giannino Patone, Kingsley Chow, Ester Khin, Jessie Tan, Sonia P Chothani, Lei Ye, Owen J L Rackham, Nicole S J Ko, Norliza E Sahib, Chee Jian Pua, Nicole T G Zhen, Chen Xie, Mao Wang, Henrike Maatz, Shiqi Lim, Kathrin Saar, Susanne Blachut, Enrico Petretto, Sabine Schmidt, Tracy Putoczki, Nuno Guimarães-Camboa, Hiroko Wakimoto, Sebastiaan van Heesch, Kristmundur Sigmundsson, See L Lim, Jia L Soon, Victor T T Chao, Yeow L Chua, Teing E Tan, Sylvia M Evans, Yee J Loh, Muhammad H Jamal, Kim K Ong, Kim C Chua, Boon-Hean Ong, Mathew J Chakaramakkil, Jonathan G Seidman, Christine E Seidman, Norbert Hubner, Kenny Y K Sin, Stuart A Cook
Fibrosis is a final common pathology in cardiovascular disease(1). In the heart, fibrosis causes mechanical and electrical dysfunction(1,2) and in the kidney, it predicts the onset of renal failure(3). Transforming growth factor β1 (TGFB1) is the principal pro-fibrotic factor(4,5) but its inhibition is associated with side effects due to its pleiotropic roles(6,7). We hypothesised that downstream effectors of TGFB1 in fibroblasts could be attractive therapeutic targets and lack upstream toxicities. Using integrated imaging-genomics analyses of primary human fibroblasts, we found that Interleukin 11 (IL11) upregulation is the dominant transcriptional response to TGFB1 exposure and required for its profibrotic effect...
November 13, 2017: Nature
https://www.readbyqxmd.com/read/29160231/hydrothermal-synthesis-of-stable-metallic-1t-phase-ws2-nanosheets-for-thermoelectric-application
#6
Mingxing Piao, Jin Chu, Xiao Wang, Yao Chi, Heng Zhang, Chaolong Li, Haofei Shi, Min-Kyu Joo
Two-dimensional (2D) materials have gained great attention as a promising thermoelectric (TE) material due to their unique density of state with confined electrons and holes. Here, we synthesized 1T phase tungsten disulfide (WS2) nanosheets with high TE performance via hydrothermal method. Flexible WS2 nanosheets restacked thin films were fabricated by employing vacuum filtration technique. The measured electrical conductivity was 45 S/cm with Seebeck coefficient of +30 μV/K at room temperature, indicating a p-type characteristic...
November 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29160132/active-h3k27me3-demethylation-by-kdm6b-is-required-for-normal-development-of-bovine-preimplantation-embryos
#7
Nhi Chung, Yanina S Bogliotti, Wei Ding, Marcela Vilarino, Kazuki Takahashi, James L Chitwood, Richard M Schultz, Pablo J Ross
The substantial epigenetic remodeling that occurs during early stages of mammalian embryonic development likely contributes to reprogramming the parental genomes from a differentiated to a totipotent state and activation of the embryonic genome. Trimethylation of lysine 27 of histone 3 (H3K27me3) is a repressive mark that undergoes global dynamic changes during preimplantation development of several species. To ascertain the role of H3K27me3 in bovine preimplantation development we perturbed the activity of KDM6B, which demethylates H3K27me3...
November 21, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29160089/a-comparison-of-multi-component-systems-approaches-to-suicide-prevention
#8
Simon Te Baker, Jennifer Nicholas, Fiona Shand, Rachel Green, Helen Christensen
OBJECTIVE: To describe the new Australian approach to suicide prevention, LifeSpan, and compare it to other multi-component intervention models. METHOD: The components, implementation strategies and effectiveness of three multi-component intervention models are described and compared in a narrative review. RESULTS: The LifeSpan, European Alliance Against Depression (EAAD), and Zero Suicide models emphasise the provision of evidence-based interventions and continuity of care...
November 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29159149/procedure-related-complications-during-endovascular-treatment-of-intracranial-saccular-aneurysms
#9
Jae-Min Ahn, Jae-Sang Oh, Seok-Mann Yoon, Jae-Hyun Shim, Hyuk-Jin Oh, Hack-Gun Bae
Objective: We evaluate the rates and outcomes of major procedure-related complications during coiling. Materials and Methods: Between 2007 and 2015, 436 intracranial saccular aneurysms were treated. Complications are categorized as three types: intraprocedural aneurysm rupture (IAR), thromboembolism (TE), and post-procedural early rebleeding (PER). And we evaluated the risk factors of procedure related complications by multivariate analysis. Results: Complications occurred in 61 aneurysms (14%)...
September 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29158416/tracking-the-genome-wide-outcomes-of-a-transposable-element-burst-over-decades-of-amplification
#10
Lu Lu, Jinfeng Chen, Sofia M C Robb, Yutaka Okumoto, Jason E Stajich, Susan R Wessler
To understand the success strategies of transposable elements (TEs) that attain high copy numbers, we analyzed two pairs of rice (Oryza sativa) strains, EG4/HEG4 and A119/A123, undergoing decades of rapid amplification (bursts) of the class 2 autonomous Ping element and the nonautonomous miniature inverted repeat transposable element (MITE) mPing Comparative analyses of whole-genome sequences of the two strain pairs validated that each pair has been maintained for decades as inbreds since divergence from their respective last common ancestor...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29158177/granger-causal-connectivity-dissociates-navigation-networks-that-subserve-allocentric-and-egocentric-path-integration
#11
Chin-Teng Lin, Te-Cheng Chiu, Yu-Kai Wang, Chun-Hsiang Chuang, Klaus Gramann
Studies on spatial navigation demonstrate a significant role of the retrosplenial complex (RSC) in the transformation of egocentric and allocentric information into complementary spatial reference frames (SRFs). The tight anatomical connections of the RSC with a wide range of other cortical regions processing spatial information support its vital role within the human navigation network. To better understand how different areas of the navigational network interact, we investigated the dynamic causal interactions of brain regions involved in solving a virtual navigation task...
November 17, 2017: Brain Research
https://www.readbyqxmd.com/read/29156932/-adequacy-of-the-dietary-intake-of-total-and-added-sugars-in-the-spanish-diet-to-the-recommendations-anibes-study
#12
Enma Ruiz, Gregorio Varela-Moreiras
INTRODUCTION: The WHO published in 2015 its recommendations for added sugars intake: < 10% of the total energy (TE) intake in both adults and children. No updated information is available in Spain. OBJECTIVES: To examine total sugar intake, mainly focused on added, and food and beverage sources. To analize fulfillment with WHO recommendations. METHODS: The ANIBES Study of a representative sample of the Spanish population (9-75 yr) was used...
October 15, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29155999/high-incomplete-skeletal-muscle-fatty-acid-oxidation-explains-low-muscle-insulin-sensitivity-in-poorly-controlled-t2d
#13
Timothy P Gavin, Jacob M Ernst, Hyo-Bum Kwak, Sarah E Caudill, Melissa A Reed, Ron T Garner, Yaohui Nie, Jessica A Weiss, Walter J Pories, Moahad Dar, Chien-Te Lin, Monica J Hubal, P Darrell Neufer, Shihuan Kuang, G Lynis Dohm
Aim: We investigated if skeletal muscle insulin sensitivity was different between well (WCD) and poorly (PCD) controlled T2D and if the difference was associated with differences due to mitochondrial respiratory function. Methods: Vastus lateralis muscle mitochondrial respiration, mitochondrial content, mitochondrial enzyme activity, and fatty acid oxidation (FAO) were measured. Insulin sensitivity (SI) and the acute response to glucose (AIRg) were calculated by MINMOD analysis from glucose and insulin obtained during a modified, frequently sampled, intravenous glucose tolerance test...
November 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29155550/carbon-fiber-ionization-mass-spectrometry-for-the-analysis-of-analytes-in-vapor-liquid-and-solid-phases
#14
Min-Li Wu, Te-Yu Chen, Yen-Chun Chen, Yu-Chie Chen
Various ionization methods in mass spectrometry (MS) are available for the analysis of analytes with different properties. Nonetheless, using a single ionization method to analyze mixtures containing analytes with different polarities and volatiles in different phases at atmospheric pressure remains a challenge. Exploring an ionization method that can ionize small organics and large biomolecules with different properties for MS analysis is advantageous. Carbon fiber ionization mass spectrometry (CFI-MS) that uses a carbon fiber bundle as the ion source is useful for the analysis of small organics with low polarities...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29155465/catalytic-dibenzocyclooctene-synthesis-via-cobalt-iii-carbene-radical-and-ortho-quinodimethane-intermediates
#15
Colet Te Grotenhuis, Naudin van den Heuvel, Jarl Ivar van der Vlugt, Bas de Bruin
Metalloradical activation of N-tosyl hydrazones 1 (o-benzallyl-aryl-tosylhydrazones), using [Co(TPP)] as a catalyst (TPP = tetraphenylporphyrin), allows controlled exploitation of single-electron reactivity of the redox non-innocent carbene intermediate. This method offers a novel route to prepare 8-membered rings, using base metal catalysis to construct a series of unique dibenzocyclooctenes via selective CcarbeneCaryl cyclization, producing the desired 8 membered ring products in good to excellent yields...
November 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29155241/multilocus-sequence-typing-based-analysis-of-moraxella-catarrhalis-population-structure-reveals-clonal-spreading-of-drug-resistant-strains-isolated-from-childhood-pneumonia
#16
Yinju Du, Haijian Zhou, Fei Wang, Shengnan Liang, Lihong Cheng, Xiaofei Du, Feng Pang, Jinjing Tian, Jinxing Zhao, Biao Kan, Jianguo Xu, Juan Li, Furong Zhang
This work revealed the drug resistance and population structure of Moraxella catarrhalis strains isolated from children less than three years old with pneumonia. Forty-four independent M. catarrhalis strains were analyzed using broth dilution antimicrobial susceptibility testing and multilocus sequence typing (MLST). The highest non-susceptibility rate was observed for amoxicillin (AMX), which reached 95.5%, followed by clindamycin (CLI) (n=33; 75.0%), azithromycin (AZM) (61.4%), cefaclor (CEC) (25.0%), trimethoprim-sulfamethoxazole (SXT) (15...
November 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29154241/przerzuty-do-otrzewnej-raka-jelita-grubego
#17
Tomasz Jastrzębski, Wojciech Zegarski
Częstość przerzutów do otrzewnej w raku jelita grubego wynosi 5%-15% w przypadku przerzutów synchronicznych i aż 40% w przypadku wystąpienia wznowy miejscowej. Najlepsze wyniki leczenia uzyskuje się poprzez skojarzone wykonanie zabiegu cytoredukcyjnego w połączeniu z dootrzewnową chemioterapią perfuzyjną w hipertermii (HIPEC). Wyniki takiego leczenia są zdecydowanie lepsze i pozwalają na osiągnięcie przeżyć 5-letnich na poziomie 30%-50%. Zabiegi te wymagają dużego doświadczenia w chirurgii jamy brzusznej, są czasochłonne (średni czas procedury chirurgicznej wynosi 6-8 godzin) i obarczone powikłaniami związanymi nie tylko z zabiegiem operacyjnym, ale także podaniem cytostatyku do jamy otrzewnej w podwyższonej temperaturze (41,5 st...
October 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29153346/gravity-tissue-engineering-and-the-missing-link
#18
Raquel Costa-Almeida, Pedro L Granja, Manuela E Gomes
The influence of microgravity and hypergravity on living systems has attracted significant attention, but the use of these tools in tissue engineering (TE) remains relatively unexplored. This Forum article highlights an emerging field of research to uncover new potential applications at the interface between altered gravity and TE.
November 16, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29153074/is-being-punished-at-school-an-indicator-of-psychosocial-risk
#19
Ana Isabel Corchado, María José Díaz-Aguado Jalón, Rosario Martínez-Arias
Research carried out in different cultural contexts shows that the use of exclusively coercive disciplinary measures does not improve the behavior of those punished, and may even increase the risks underpinning those behaviors. The aim of this research was to study whether there is a link between repeatedly suffering punishment at school and psychosocial risks in adolescence. A non-experimental design was implemented with selected groups. The participants were 507 adolescents from four groups with different risk levels: in social protection (n = 189); subject to court measures (n = 104); in treatment for drug abuse (n = 25); and comparison group (n = 189)...
November 20, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/29152924/population-based-birth-defects-data-in-the-united-states-2010-2014-a-focus-on-gastrointestinal-defects
#20
Philip J Lupo, Jennifer L Isenburg, Jason L Salemi, Cara T Mai, Rebecca F Liberman, Mark A Canfield, Glenn Copeland, Sarah Haight, Sanjiv Harpavat, Adrienne T Hoyt, Cynthia A Moore, Wendy N Nembhard, Hoang N Nguyen, Rachel E Rutkowski, Amy Steele, C J Alverson, Erin B Stallings, Russell S Kirby
BACKGROUND: Gastrointestinal defects are a phenotypically and etiologically diverse group of malformations. Despite their combined prevalence and clinical impact, little is known about the epidemiology of these birth defects. Therefore, the objective of the 2017 National Birth Defects Prevention Network (NBDPN) data brief was to better describe the occurrence of gastrointestinal defects. METHODS: As part of the 2017 NBDPN annual report, 28 state programs provided additional data on gastrointestinal defects for the period 2010-2014...
November 1, 2017: Birth defects research
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