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K B Beck, B L Hønge, J S Olesen, M S Petersen, S Jespersen, C Wejse, Z J da Silva, C Medina, D D S Té, B K Moeller, C S Benn, P Aaby, C Erikstrup
BACKGROUND: Smallpox vaccinations were stopped globally in 1980. Recent studies have shown that in women, being smallpox vaccinated was associated with a reduced risk of HIV infection compared with not being smallpox vaccinated. At the initial infection, HIV-1 most often uses CCR5 as a co-receptor to infect the T-lymphocytes. We therefore investigated whether smallpox vaccination is associated with a down-regulation of CCR5 on the surface of peripheral T-lymphocytes in healthy women in Guinea-Bissau...
2018: PloS One
Don M Ragot, J Jean Chen
In this work, we characterize contrast origins and noise contributions of spin echo (SE) EPI BOLD signal at 3 T. SE BOLD is a fMRI method of choice for imaging brain regions affected by susceptibility artifacts at lower fields, but its sensitivity remains a limiting factor for whole-brain imaging. To resolve this, the signal and noise contributions as well as TE dependence of SE EPI are characterized in this study. By integrating a two-compartment BOLD model with a physiological-thermal noise model, a new SE-BOLD signal model was introduced...
November 12, 2018: Magnetic Resonance Imaging
Naiade B G Marques, Raquel G Jacob, Gelson Perin, Eder J Lenardão, Diego Alves, Márcio S Silva
Here, we report the general strategies by which NMR spectroscopy can be used to determine the enantiopurity and absolute configuration of chalcogen containing secondary alcohols, including the evaluation of the use of chiral solvating and chiral derivatizing agents. The BINOL/DMAP ternary complex demonstrated a simple and fast protocol for determining enantiopurity. The drug Naproxen afforded a stable, nonhygroscopic, and readily available chiral derivatizing agent (CDA) for NMR chiral discrimination of chalcogen containing secondary alcohols...
November 15, 2018: Chirality
Min Wu, Yixuan Wang, Hongyu Wang, Hao Wang, Yongming Sui, Fei Du, Xinyi Yang, Bo Zou
A colloidal strategy offers opportunities for the rational design and synthesis of metal telluride nanocrystals (NCs) with the desired crystal structure, uniform geometry, and composition. However, it remains a challenge to use the paradigm to construct metal telluride NCs by a phosphine-free synthesis procedure for promising applications such as luminescence, photovoltaics and thermoelectricity. Here, we developed a new strategy for fabricating metal telluride nanocrystals, e.g. CdTe and PbTe NCs, by using a highly reactive phosphine-free Te precursor...
November 15, 2018: Nanoscale
Te-Min Ke, Yao Fong, Li-Ching Lin, Yu-Wun Chien, Ching-Chieh Yang, Chia-Hui Lin, Kuei-Li Lin, Jenny Que
The optimal radiation dose for definitive chemoradiotherapy in inoperable esophageal squamous cell carcinoma (ESCC) has been long debated. In this study, we evaluated the effect of doses greater than the conventional radiation dose (50.4 Gy) on tumor control, tumor response, overall survival (OS), and disease-free survival (DFS).The database of patients diagnosed with inoperable ESCC from 2007 to 2015 was obtained from the cancer registry of Chi-Mei Medical Center. All categorical variables were compared using Chi-squared test...
November 2018: Medicine (Baltimore)
Bingwei Li, Luhan Li, Qiuju Zhang, Honggang Zhang, Ruijuan Xiu
OBJECTIVE: To investigate the effects of TNF-α-induced exosomes release on the biological behavior, metabolism and bioenergetics of HUVECs. METHODS: Exosomes were isolated from conditioned media of HUVECs by ultracentrifugation after treatment with or without TNF-α. HUVECs were treated with or without TNF-α, or different concentrations of exosomes isolated from conditioned media with or without TNF-α induction (TE xo and CE xo , respectively). RESULTS: The results showed that TNF-α significantly inhibited migration, tube formation, and increased apoptosis rate of HUVECs compared with controls...
November 15, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Guozong Wang, Zhentao Man, Nianping Zhang, Hua Xin, Yi Li, Tiantong Sun, Shui Sun
Osteonecrosis of the femoral head (ONFH) is a refractory disease present worldwide. In the development of therapies for this disease, mesenchymal stem cells (MSC) are a promising candidate cell source in tissue engineering (TE) and regenerative medicine. MSCs harvested from bone marrow (BM) are the gold standard. A significant barrier for BMMSC‑based therapies is the inability and decreased number of BMMSCs in the tissues of interest. The ability to recruit BMMSCs efficiently to defective or injured sites in tissues or organs, for example the necrotic area of the femoral head in vivo, has been a major concern...
November 5, 2018: Molecular Medicine Reports
Yao Lu, Yang Qiu, Qinglin Jiang, Kefeng Cai, Yong Du, Haijun Song, Mingyuan Gao, Changjun Huang, Jiaqing He, Dehua Hu
In this work, Te/PEDOT:PSS/Cu7 Te4 ternary thermoelectric (TE) nanocomposite films were successfully fabricated by physical mixing and then drop casting. An optimized power factor of 65.3 μW/mK2 was acquired from a composite film containing 95 wt% PEDOT:PSS coated Te (PC-Te) nanorods at 300 K, which was 5 times as large as that of PC-Cu7 Te4 nanorod film and about 3 times as large as that of the PC-Te nanorod film. The power factor reached 112.3 μW/mK2 when the temperature was 380 K. STEM and HRSTEM were used to observe the detailed internal microstructure of the composite film, revealing that the Te rods were single crystalline and the Cu7 Te4 rods polycrystalline...
November 15, 2018: ACS Applied Materials & Interfaces
Vered Nir, Michal Gur, Yazeed Toukan, Fahed Hakim, Arcadi Vachyan, Lea Bentur
BACKGROUND: Recurrence of tracheoesophageal fistula (TEF) is reported in 8-20% patients. Factors that may influence recurrence of fistula beyond the postoperative period are not clear. OBJECTIVES: To evaluate possible factors associated with recurrence of TEF beyond the immediate postoperative period. METHODS: A single center, retrospective comparison of patients with and without recurrence of TEF was conducted. Medical records of patients previously operated for TEF who were followed in our pediatric pulmonary institute between January 2007 and December 2016 were reviewed...
November 2018: Israel Medical Association Journal: IMAJ
Rodrigo Modolo, Yosuke Miyazaki, Chun Chin Chang, Maaike Te Lintel Hekkert, Math van Sloun, Todd Suchecki, Jean-Paul Aben, Osama I Soliman, Yoshinobu Onuma, Dirk J Duncker, Nicolas M van Mieghem, Patrick W Serruys
OBJECTIVES: To evaluate the in vivo feasibility of aortography with one accurately timed diastolic low-volume contrast injection for quantitative assessment of aortic regurgitation (AR) post transcatheter aortic valve replacement (TAVR). BACKGROUND: With the rise of a minimalistic approach for TAVR, aortography (re)emerges as a pragmatic tool for AR assessment. In a mock circulation system, we have validated the accuracy of a single diastolic injection triggered by electrocardiogram (ECG) with low-contrast volume...
November 15, 2018: Catheterization and Cardiovascular Interventions
K Hatsuda, H Mine, T Nakamura, J Li, R Wu, S Katsumoto, J Haruyama
Realization of the quantum spin Hall effect in graphene devices has remained an outstanding challenge dating back to the inception of the field of topological insulators. Graphene's exceptionally weak spin-orbit coupling-stemming from carbon's low mass-poses the primary obstacle. We experimentally and theoretically study artificially enhanced spin-orbit coupling in graphene via random decoration with dilute Bi2 Te3 nanoparticles. Multiterminal resistance measurements suggest the presence of helical edge states characteristic of a quantum spin Hall phase; the magnetic field and temperature dependence of the resistance peaks, x-ray photoelectron spectra, scanning tunneling spectroscopy, and first-principles calculations further support this scenario...
November 2018: Science Advances
Wei-Hsun Tai, Li-I Wang, Hsien-Te Peng
The purpose of this study was to determine the differences in biomechanical characteristics between one- and two-legged running vertical jumps (1-LRVJ and 2-LRVJ). Ten male college volleyball players voluntarily participated in this study. Two running vertical jumps used in volleyball were randomly performed. Three trials for each type of the running vertical jump were recorded for each participant. Data were collected using six infra-red Qualisys motion-capture cameras at a 180-Hz sampling rate and two AMTI force platforms at an 1800-Hz sampling rate...
September 2018: Journal of Human Kinetics
M A J van Kelle, P J A Oomen, W J T Janssen-van den Broek, R G P Lopata, S Loerakker, C V C Bouten
In situ cardiovascular tissue-engineering can potentially address the shortcomings of the current replacement therapies, in particular, their inability to grow and remodel. In native tissues, it is widely accepted that physiological growth and remodelling occur to maintain a homeostatic mechanical state to conserve its function, regardless of changes in the mechanical environment. A similar homeostatic state should be reached for tissue-engineered (TE) prostheses to ensure proper functioning. For in situ tissue-engineering approaches obtaining such a state greatly relies on the initial scaffold design parameters...
November 14, 2018: Journal of the Royal Society, Interface
Mong-Wei Lin, Kang-Yi Su, Te-Jen Su, Chia-Ching Chang, Jing-Wei Lin, Yi-Hsuan Lee, Sung-Liang Yu, Jin-Shing Chen, Min-Shu Hsieh
OBJECTIVE: Histologic transformation from adenocarcinoma to small cell lung cancer (SCLC) is one of the mechanisms of acquired resistance after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment. Furthermore, de novo combined SCLC/non-small cell lung cancer (NSCLC) have occasionally been reported; however, their mutational statuses and clinicopathological features have not yet been elucidated. In this study, we aimed to profile the genetic backgrounds of these 2 different histologic components by investigating patients with de novo combined SCLC/NSCLC as well as those with lung adenocarcinoma who experienced SCLC transformation after TKI treatment...
November 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Qiong Wu, Neil A Smith, Daai Zhang, Changyong Zhou, Ming-Bo Wang
Transposable elements (TEs) are widespread in the plant genome and can impact on the expression of neighbouring genes. Our previous studies have identified a number of DNA demethylase-regulated defence-related genes that contain TE sequences in the promoter and show tissue-specific expression in Arabidopsis. In this study we investigated the role of the promoter TE insertions in the root-specific expression of a DNA demethylase-regulated gene, AT5G38550 , encoding a Jacalin lectin family protein. Using a promoter:GUS fusion reporter gene approach, we first demonstrated that the full-length promoter fragment, carrying four TE sequences, contained the essential regulatory information required for root-specific expression and DNA demethylase regulation in Arabidopsis...
November 13, 2018: Genes
Zhenglin Yang, Kang Yong Loh, Yueh-Te Chu, Ruopei Feng, Nitya Sai Reddy Satyavolu, Mengyi Xiong, Stephanie M Nakamata Huynh, Kevin Hwang, Lele Li, Hang Xing, XiaoBing Zhang, Yann R Chemla, Martin Gruebele, Yi Lu
Spatial and temporal distributions of metal ions in vitro and in vivo are crucial in our understanding of the roles of metal ions in biological systems, and yet there is a very limited number of methods to probe metal ions with high space and time resolution, especially in vivo. To overcome this limitation, we report a Zn2+-specific near infrared (NIR) DNAzyme nanoprobe for real-time metal ion tracking with spatiotemporal control in early embryos and larvae of zebrafish. By conjugating photocaged DNAzymes onto lanthanide-doped upconversion nanoparticles (UCNPs), we have achieved upconversion of a deep tissue penetrating NIR 980 nm light into 365 nm emission...
November 14, 2018: Journal of the American Chemical Society
Yatian Liu, Xiaojun Wang, Xuesong Jiang, Pengwei Yan, Liangliang Zhan, Huanfeng Zhu, Tingting Wang, Jing Wen
Aberrant microRNAs (miRNAs) expressions could contribute to the progression of numerous cancers, including esophageal squamous cell carcinoma, while miR-10a participates in multiple biological processes on cancers. However, the molecular mechanism of miR-10a in esophageal squamous cell carcinoma (ESCC) has not been investigated. Herein, miR-10a was significantly reduced in ESCC clinical tissues and ESCC cell lines (EC109 and TE-3). In addition, immunohistochemistry indicated that the expressions of α-SMA, Ki-67, and PCNA in tumor tissues were higher than that of controls...
November 13, 2018: Journal of Cellular Biochemistry
Amir Altaf, Munkyo Seo
In this paper, a triple-band dual-sense circularly polarized (CP) hybrid dielectric resonator antenna is proposed. A modified hexagonal dielectric resonator (DR) is top-loaded with a square microstrip ring (SMR). A vertical-tapered-strip connected to a 50- Ω microstrip line is used to excite the proposed antenna. It is found that the lower and central CP bands correspond to left-handed circular polarization and are produced by the TM 11 and TE 111 modes of the SMR and modified hexagonal DR, respectively. The upper CP band is formed by the combination of the quasi-TM 21 mode of the SMR and quasi-TE 111 mode of the DR that exhibits right-handed circular polarization...
November 12, 2018: Sensors
I-Te Lee, Wayne Huey-Herng Sheu
Circulating brain-derived neurotrophic factor (BDNF) predicts survival rate in patients with coronary artery disease (CAD). We examined the relationship between BDNF and renalase before and after percutaneous coronary intervention (PCI) and the role of renalase in patients with CAD. Serum BDNF and renalase levels were determined using blood samples collected before and after PCI. Incident myocardial infarction, stroke, and mortality were followed up longitudinally. A total of 152 patients completed the assessment...
November 12, 2018: Journal of Clinical Medicine
Kana Fukuie, Yoshitaka Iwata, Eiji Iwase
A stretchable thermoelectric (TE) generator was developed by using rigid BiTe-based TE elements and a non-stretchable substrate with origami-like folding deformation. Our stretchable TE generator contains flat sections, on which the rigid TE elements are arranged, and folded sections, which produce and guarantee the stretchability of a device. First, a simple stretchable device with a single pair of p-type and n-type BiTe-based TE elements was designed and fabricated. The TE elements were sandwiched between two folded polyimide-copper substrates...
June 22, 2018: Micromachines
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