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https://www.readbyqxmd.com/read/29222067/role-of-extracellular-vesicles-in-glioma-progression
#1
REVIEW
Claudia Quezada, Ángelo Torres, Ignacio Niechi, Daniel Uribe, Susana Contreras Duarte, Fernando Toledo, Rody San Martín, Jaime Gutiérrez, Luis Sobrevia
The role of extracellular vesicles in cancer biology has emerged as a focus of the study of great importance and has been shown to directly influence tumour development in several cancers including brain tumours, such as gliomas. Gliomas are the most aggressive brain tumours, and in the last time, a considerable effort has been made to understand their biology. Studies focus in the signalling pathways involved in the processes of angiogenesis, viability, drug resistance and immune response evasion, as well as gliomas ability to infiltrate healthy tissue, a phenomenon regulated by the migratory and invasive capacity of the cells within a tumour...
December 5, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29219011/meconium-aspiration-syndrome-risk-factors-and-predictors-of-severity
#2
Cláudia Patrícia Lourenço Oliveira, Filipa Flôr-de-Lima, Gustavo Marcondes Duarte Rocha, Ana Paula Machado, Maria Hercília Ferreira Guimarães Pereira Areias
PURPOSE: To identify risk factors and predictors of severity associated with meconium aspiration syndrome (MAS) in the patients admitted to the neonatal intensive care unit (NICU). MATERIALS AND METHODS: Retrospective study including newborns admitted, between 2005 and 2015, with a diagnosis of MAS. RESULTS: Of the newborns admitted to the NICU, 0.66% were diagnosed with MAS. These had higher prevalence of caesarean delivery (p < .001), nonreassuring or abnormal cardiotocography (CTG) (p < ...
December 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29217816/wunderlich-s-syndrome-or-spontaneous-retroperitoneal-hemorrhage-in-a-patient-with-tuberous-sclerosis-and-bilateral-renal-angiomyolipoma
#3
Sara Catarino Santos, Liliana Duarte, Fernando Valério, Júlio Constantino, Jorge Pereira, Carlos Casimiro
BACKGROUND Wunderlich's syndrome, or spontaneous non-traumatic retroperitoneal hemorrhage, can be a life-threatening event. Renal angiomyolipoma is a rare benign tumor that can occur sporadically, or in association with tuberous sclerosis. A case of spontaneous retroperitoneal hemorrhage in a patient with tuberous sclerosis and bilateral renal angiomyolipoma is presented. CASE REPORT A 33-year-old female Caucasian patient, with a known medical history of tuberous sclerosis, was admitted to hospital as an emergency, with right-sided abdominal pain...
December 8, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29217418/molecular-characterization-of-virulence-and-antimicrobial-resistance-profile-of-shigella-species-isolated-from-children-with-moderate-to-severe-diarrhea-in-northeastern-brazil
#4
Pedro Henrique Quintela Soares Medeiros, Aldo Ângelo Moreira Lima, Marjorie Moreira Guedes, Alexandre Havt, Mariana Duarte Bona, Luís Carlos Rey, Alberto Melo Soares, Richard Littleton Guerrant, Bernhard H Weigl, Ila Fernanda Nunes Lima
Molecular characterization of virulence and antimicrobial resistance profiles were determined for Shigella species isolated from children with diarrhea in Fortaleza, Brazil. Fecal specimens were collected along with socioeconomic and clinical data from children with moderate to severe diarrhea requiring emergency care. Shigella spp. were isolated by standard microbiological techniques, and we developed 4 multiplex polymerase chain reaction assays to detect 16 virulence-related genes (VRGs). Antimicrobial susceptibility tests were performed using disk diffusion assays...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29215683/instrument-design-may-influence-bacterial-reduction-during-root-canal-preparation
#5
Manoel Eduardo de Lima Machado, Cleber Keiti Nabeshima, Hector Caballero-Flores, Moyzés Elmadjian-Filho, Marco Antônio Húngaro Duarte, Ronald Odinola-Zapata, Silvana Cai
The aim of this study was to evaluate the bacterial reduction promoted by ProTaper Next and Twisted File by comparing to ProTaper Universal and manual technique. Sixty distobuccal root canals of maxillary molars sterilized with ethylene oxide were contaminated with Enterococcus faecalis broth culture. After incubation for 21 days, bacterial samples were collected and cultured on m-Enterococcus agar plates. The root canals were divided into 4 groups, according to the system used for instrumentation: ProTaper Next, Twisted File, ProTaper Universal, and crown down manual technique...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29215423/galt-deficiency-galactosemia
#6
Sharon Anderson
Galactosemia is an inborn error of galactose metabolism that results from a deficiency in one of three enzymes, uridine diphosphate galactose 4'epimerase, galactokinase, or galactose-1-phosphate uridyltransferase (GALT). This article focuses on classical, clinical variant, and biochemical variant (Duarte) galactosemias caused by GALT enzyme deficiency. A brief overview of galactosemia and newborn screening is presented, followed by detailed information about each of the conditions. Confirmatory testing, acute and long-term management, and outcome for these galactosemia types are discussed as well as the importance of genetic counseling and testing for the infant and family to refine reproductive risk...
January 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29214980/ion-chambers-compliance-results-of-brazilian-radiation-therapy-facilities
#7
Georgia Santos Joana, Camila Salata, Paulo Leal, Renato Oliveira, Nozimar do Couto, Flavia Cristina Teixeira, Abner Duarte Soares, Eduardo Sergio Santini, Marcello Gomes Gonçalves
Brazilian Nuclear Energy Commission (cnen) has been making a constant effort to keep updated with international standards and national needs to strengthen the status of radiological protection of the country. The guidelines related to radiation therapy facilities have been revised in the last five years in order to take in consideration the most relevant aspects of the growing technology as well as to mitigate the accidents or incidents observed in practice. Hence, clinical dosimeters have gained special importance in this matter...
December 7, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29213518/cognitive-impairment-of-patients-with-chronic-renal-disease-on-hemodialysis-and-its-relationship-with-sociodemographic-and-clinical-characteristics
#8
Gabriela Dutra Gesualdo, Juliana Gomes Duarte, Marisa Silvana Zazzetta, Luciana Kusumota, Karina Gramani Say, Sofia Cristina Iost Pavarini, Fabiana de Souza Orlandi
Cognitive impairment and dementia commonly occur in individuals with chronic kidney disease, especially in advanced stages, but are still poorly diagnosed. OBJECTIVE: To evaluate the cognitive ability of patients with chronic kidney disease on hemodialysis and its relationship with sociodemographic and clinical characteristics. METHODS: A cross-sectional study was carried out in a Renal Replacement Therapy Unit in the interior of the State of São Paulo involving 99 patients...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29211658/letermovir-prophylaxis-for-cytomegalovirus-in-hematopoietic-cell-transplantation
#9
Francisco M Marty, Per Ljungman, Roy F Chemaly, Johan Maertens, Sanjeet S Dadwal, Rafael F Duarte, Shariq Haider, Andrew J Ullmann, Yuta Katayama, Janice Brown, Kathleen M Mullane, Michael Boeckh, Emily A Blumberg, Hermann Einsele, David R Snydman, Yoshinobu Kanda, Mark J DiNubile, Valerie L Teal, Hong Wan, Yoshihiko Murata, Nicholas A Kartsonis, Randi Y Leavitt, Cyrus Badshah
Background Cytomegalovirus (CMV) infection remains a common complication after allogeneic hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV-terminase complex. Methods In this phase 3, double-blind trial, we randomly assigned CMV-seropositive transplant recipients, 18 years of age or older, in a 2:1 ratio to receive letermovir or placebo, administered orally or intravenously, through week 14 after transplantation; randomization was stratified according to trial site and CMV disease risk...
December 6, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29211285/intradentinal-antimicrobial-action-and-filling-quality-promoted-by-ultrasonic-agitation-of-epoxy-resin-based-sealer-in-endodontic-obturation
#10
Murilo Priori Alcalde, Clóvis Monteiro Bramante, Rodrigo Ricci Vivan, Pablo Andrés Amorso-Silva, Flaviana Bombarda de Andrade, Marco Antonio Hungaro Duarte
MATERIAL AND METHODS: The aim of this study was evaluate the influence of ultrasonic activation (UA) of AH Plus to improve canal and isthmus filing, and analyse the antimicrobial effect against Enterococcus faecalis within dentinal tubules. Thirty mesial roots of mandibular first molars were selected and divided into 2 groups (n = 15): with and without UA of the sealer. Then the root canals were filled by using the single cone technique, and the specimens were sectioned at 2, 4 and 6 mm from the apex for stereomicroscope and confocal laser scanner microscopy (CLSM) analysis...
November 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29211240/natural-environmental-water-sources-in-endemic-regions-of-northeastern-brazil-are-potential-reservoirs-of-viable-mycobacterium-leprae
#11
Maria Luisa Bezerra de Macedo Arraes, Maísa Viana de Holanda, Luana Nepomuceno Gondim Costa Lima, José Antônio Beltrão Sabadia, Cynthia Romariz Duarte, Rosa Livia Freitas Almeida, Carl Kendall, Ligia Regina Sansigolo Kerr, Cristiane Cunha Frota
BACKGROUND: The detection of live Mycobacterium leprae in soil and animals other than humans suggests that the environment plays a role in the transmission of leprosy. OBJECTIVE: The objective of this study was to investigate the presence of viable M. leprae in natural water sources used by the local population in five municipalities in the state of Ceará, northeastern Brazil. METHODS: Samples were collected from 30 different sources. Viable bacilli were identified by reverse transcriptase polymerase chain reaction (PCR) of the M...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29211173/-josu%C3%A3-de-castro-and-brazilian-social-thought
#12
Mercês de Fátima Dos Santos Silva, Everardo Duarte Nunes
This article highlights the fact that the work of Josué de Castro brings to light some of the most relevant interpretations on the Brazilian food situation, launching the first proactive manifesto for the construction of a social policy on food in Brazil. Underpinning this debate, there are aspects of the process of construction of the Nation State, national development and the role of the Brazilian intellectuals. Such issues are added to the author's concern with the formation of proactive measures that could lead to social change and redefinitions of the conditions of social exclusion of a significant portion of the Brazilian population...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211159/social-inequalities-in-limitations-caused-by-chronic-diseases-and-disabilities-in-brazil-the-2013-national-health-survey
#13
Patricia de Moraes Mello Boccolini, Cristina Maria Rabelais Duarte, Miguel Abud Marcelino, Cristiano Siqueira Boccolini
This paper aims to evaluate the association between social inequalities and self-reported limitations for the performance of daily activities caused by chronic diseases or disabilities. The 2013 National Health Survey evaluated a sample of Brazilians with 18+ years. The outcome was that individuals reported that their daily activities were moderately, severely or very severely limited (LIMIT) by one or more chronic diseases, or mental, physical, hearing or motor impairment. The main exposure was the economy class, classified into five categories, ranging from A (richest) to E (poorest)...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211157/social-protection-and-public-policy-for-vulnerable-populations-an-assessment-of-the-continuous-cash-benefit-program-of-welfare-in-brazil
#14
Cristina Maria Rabelais Duarte, Miguel Abud Marcelino, Cristiano Siqueira Boccolini, Patrícia de Moraes Mello Boccolini
This paper describes the historical development and profile of Continuous Cash Benefit (BPC) applicants, intended for poor elderly and people with disabilities, which, since 2009, uses eligibility criteria based on the International Classification of Functioning, Disability and Health (ICF) of the WHO and is aligned with the UN Convention on the Rights of Persons with Disabilities. The behavior of benefits was determined from the analysis the coefficients of the general and non-judicial grants between 1998 and 2014...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211126/effect-of-reciprocating-systems-and-working-lengths-on-apical-microcrack-development-a-micro-ct-study
#15
Bruna Paloma de Oliveira, Andréa Cruz Câmara, Daniel Amancio Duarte, Richard John Heck, Antonio Celso Dantas Antonino, Carlos Menezes Aguiar
The objective of this study was to evaluate the effect of root canal preparation with single-file reciprocating systems at different working lengths on the development of apical microcracks using micro-computed tomographic (micro-CT) imaging. Forty extracted human mandibular incisors were randomly assigned to 4 groups (n=10) according to the systems and working length used to prepare the root canals: Group A - WaveOne Gold at apical foramen (AF), Group B - WaveOne Gold 1 mm short of the AF (AF-1 mm), Group C - Unicone (AF) and Group D - Unicone (AF-1 mm)...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29210947/toward-optimizing-cervical-vestibular-evoked-myogenic-potentials-cvemp-combining-air-bone-gap-and-cvemp-thresholds-to-improve-diagnosis-of-superior-canal-dehiscence
#16
Kimberley S Noij, Maria J Duarte, Kevin Wong, Y Song Cheng, Salwa Masud, Barbara S Herrmann, Hugh D Curtin, Vivek V Kanumuri, John J Guinan, Elliott D Kozin, Osama Tarabichi, David H Jung, Daniel J Lee, Steven D Rauch
OBJECTIVE: To develop a novel approach combining low-frequency air-bone gap (ABG) and cervical vestibular evoked myogenic potential (cVEMP) thresholds to improve screening for superior canal dehiscence (SCD) syndrome. STUDY DESIGN: Retrospective study. SETTING: Tertiary care center. PATIENTS: One hundred forty patients with SCD and 21 healthy age-matched controls were included. Ears for each patient were divided into three groups based on computed tomography (CT) findings: 1) dehiscent, 2) thin, or 3) unaffected...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29210106/preemptive-second-kidney-transplantation-is-associated-with-better-graft-survival-compared-to-non-preemptive-second-transplantation-a-multicenter-french-2000-2014-cohort-study
#17
S Girerd, N Girerd, K Duarte, C Legendre, G Mourad, V Garrigue, E Morelon, F Buron, N Kamar, A Del Bello, M Ladrière, M Kessler, L Frimat
BACKGROUND: The impact of preemptive second kidney transplantation (2KT) on graft and patient survival is poorly established. METHODS: The association between preemptive 2KT (p2KT, N=93) and outcomes was estimated in a multicenter French cohort of 2KT (N=1314) recipients using propensity score methods. RESULTS: During follow-up, there were 274 returns to dialysis and 134 deaths. p2KT was associated with lower death-censored graft loss = 0...
December 5, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29209338/can-aquatic-plants-keep-pace-with-climate-change
#18
Duarte S Viana
The persistence of species may depend upon their capacity to keep pace with climate change. However, dispersal has been ignored in the vast majority of studies that aimed at estimating and predicting range shifts as a response to climate change. Long distance dispersal (LDD) in particular might promote rapid range shifts and allow species to track suitable habitat. Many aquatic plant species are dispersed by birds and have the potential to be dispersed over hundreds of kilometers during the bird migration seasons...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29209061/car-t-cells-the-narrow-path-between-hope-and-bankruptcy
#19
EDITORIAL
C Chabannon, J Kuball, E Mcgrath, P Bader, C Dufour, A Lankester, G W Basak, S Montoto, A Nagler, J A Snowden, J Styczynski, R F Duarte, N Kröger, M Mohty
No abstract text is available yet for this article.
December 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29208022/role-of-endoplasmic-reticulum-stress-in-the-protective-effects-of-ppar%C3%AE-%C3%AE-activation-on-endothelial-dysfunction-induced-by-plasma-from-patients%C3%A2-with-lupus
#20
Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio, Juan Duarte
BACKGROUND: We tested whether GW0742, a peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) agonist, improves endothelial dysfunction induced by plasma from patients with systemic lupus erythematosus (SLE) involving the inhibition of endoplasmic reticulum (ER) stress. METHODS: A total of 12 non-pregnant women with lupus and 5 non-pregnant healthy women (controls) participated in the study. Cytokines and double-stranded DNA autoantibodies (anti-dsDNA) were tested in plasma samples...
December 6, 2017: Arthritis Research & Therapy
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