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https://www.readbyqxmd.com/read/29452968/analysis-and-description-of-disease-specific-quality-of-life-in-patients-with-anal-fistula
#1
Manuel Ferrer-Márquez, Natalia Espínola-Cortés, Ángel Reina-Duarte, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla
INTRODUCTION: In patients diagnosed with anal fistula, knowing the quality of life specifically related to the disease can help coloproctology specialists to choose the most appropriate therapeutic strategy for each case. The aim of our study is to analyzse and describe the factors related to the specific quality of life in a consecutive series of patients diagnosed with anal fistula. METHODS: Observational, cross-sectional study carried out from March 2015 to February 2017...
February 13, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29451621/a-comparison-of-the-efficiency-of-22g-versus-25g-needles-in-eus-fna-for-solid-pancreatic-mass-assessment-a-systematic-review-and-meta-analysis
#2
Hugo Gonçalo Guedes, Diogo Turiani Hourneaux de Moura, Ralph Braga Duarte, Martin Andres Coronel Cordero, Marcos Eduardo Lera Dos Santos, Spencer Cheng, Sergio Eiji Matuguma, Dalton Marques Chaves, Wanderley Marques Bernardo, Eduardo Guimarães Hourneaux de Moura
Our aim in this study was to compare the efficiency of 25G versus 22G needles in diagnosing solid pancreatic lesions by EUS-FNA. We performed a systematic review and meta-analysis. Studies were identified in five databases using an extensive search strategy. Only randomized trials comparing 22G and 25G needles were included. The results were analyzed by fixed and random effects. A total of 504 studies were found in the search, among which 4 randomized studies were selected for inclusion in the analysis. A total of 462 patients were evaluated (233: 25G needle/229: 22G needle)...
2018: Clinics
https://www.readbyqxmd.com/read/29449204/national-food-nutrition-and-physical-activity-survey-of-the-portuguese-general-population-2015-2016-protocol-for-design-and-development
#3
Carla Lopes, Duarte Torres, Andreia Oliveira, Milton Severo, Sofia Guiomar, Violeta Alarcão, Elisabete Ramos, Sara Rodrigues, Sofia Vilela, Luísa Oliveira, Jorge Mota, Pedro J Teixeira, Paulo J Nicola, Simão Soares, Lene Frost Andersen
BACKGROUND: The assessment of food consumption data using harmonized methodologies at the European level is fundamental to support the development of public policies. Portugal is one of the countries with the most outdated information on individual food consumption. OBJECTIVE: The objective of this study was to describe the design and methodology of the National Food, Nutrition and Physical Activity Survey, 2015-2016, developed to collect national and regional data on dietary habits, physical activity (PA), and nutritional status, in a representative sample of the Portuguese general population (3 months-84 years)...
February 15, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29448126/sub-lethal-effects-of-herbicides-penoxsulam-imazamox-fluridone-and-glyphosate-on-delta-smelt-hypomesus-transpacificus
#4
Jiali Jin, Tomofumi Kurobe, Wilson F Ramírez-Duarte, Melissa B Bolotaolo, Chelsea H Lam, Pramod K Pandey, Tien-Chieh Hung, Marie E Stillway, Leanna Zweig, Jeffrey Caudill, Li Lin, Swee J Teh
Concerns regarding non-target toxicity of new herbicides used to control invasive aquatic weeds in the San Francisco Estuary led us to compare sub-lethal toxicity of four herbicides (penoxsulam, imazamox, fluridone, and glyphosate) on an endangered fish species Delta Smelt (Hypomesus transpacificus). We measured 17β-estradiol (E2) and glutathione (GSH) concentrations in liver, and acetylcholinesterase (AChE) activity in brain of female and male fish after 6 h of exposure to each of the four herbicides. Our results indicate that fluridone and glyphosate disrupted the E2 concentration and decreased glutathione concentration in liver, whereas penoxsulam, imazamox, and fluridone inhibited brain AChE activity...
February 1, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29448066/single-step-purification-via-magnetic-nanoparticles-of-new-broad-ph-active-protease-from-penicillium-aurantiogriseum
#5
José Manoel Wanderley Duarte Neto, Maria Carolina de Albuquerque Wanderley, Carolina de Albuquerque Lima, Ana Lúcia Figueiredo Porto
A new set of applications can be achieved when using high stability proteases. Industrially, high costs can be related to production medium and purification process. Magnetic nanoparticles have been successfully used for rapid and scalable purification. In this work, azocasein were immobilized on magnetite nanoparticles and applied in a single step purification of protease produced by Penicillium aurantiogriseum using soybean flour medium, and the new purified enzyme was characterized. Glutaraldehyde activated nanoparticles were used in azocasein immobilization and then incubated with dialyzed 60-80% saline precipitation fraction of crude extract for purification...
February 12, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29448040/comparing-the-therapeutic-efficacy-of-different-amphotericin-b-carrying-delivery-systems-against-visceral-leishmaniasis
#6
Débora V C Mendonça, Vívian T Martins, Daniela P Lage, Daniel S Dias, Patrícia A F Ribeiro, Ana Maria R S Carvalho, Anna Letícia T Dias, Carolina K Miyazaki, Daniel Menezes-Souza, Bruno M Roatt, Carlos A P Tavares, José Mário Barichello, Mariana C Duarte, Eduardo A F Coelho
Amphotericin B (Amp) has been well-successfully used to treat against Leishmania infection, although high toxicity has been found in patients. In the present study, Amp was administered in Leishmania infantum-infected BALB/c mice by three distinct delivery systems aiming to compare their efficacy against challenge infection, as well as their side effects in a murine visceral leishmaniasis (VL) model. This product was administered in a Poloxamer P407 (Pluronic ® F127)-based polymeric micelle system (Amp/M), in the Ambisome ® formulation (Lip-Amp) or in a free format (free Amp)...
February 12, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29448019/recovery-of-black-necked-swans-macrophytes-and-water-quality-in-a-ramsar-wetland-of-southern-chile-assessing-resilience-following-sudden-anthropogenic-disturbances
#7
Eduardo Jaramillo, Nelson A Lagos, Fabio A Labra, Enrique Paredes, Emilio Acuña, Daniel Melnick, Mario Manzano, Carlos Velásquez, Cristian Duarte
In 2004 migration and mortality for unknown reasons of the herbivorous Black necked swan (Cygnus melancorhyphus (Molina, 1782)) occurred within the Río Cruces wetland (southern Chile), a Ramsar Site and nature sanctuary. Before 2004, this wetland hosted the largest breeding population of this water bird in the Neotropic Realm. The concurrent decrease in the spatial occurrence of the aquatic plant Egeria densa Planch. 1849 - the main food source of swans - was proposed as a cause for swan migration and mortality...
February 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29441237/comparison-of-complex-networks-and-tree-based-methods-of-phylogenetic-analysis-and-proposal-of-a-bootstrap-method
#8
Aristóteles Góes-Neto, Marcelo V C Diniz, Daniel S Carvalho, Gilberto C Bomfim, Angelo A Duarte, Jerzy A Brzozowski, Thierry C Petit Lobão, Suani T R Pinho, Charbel N El-Hani, Roberto F S Andrade
Complex networks have been successfully applied to the characterization and modeling of complex systems in several distinct areas of Biological Sciences. Nevertheless, their utilization in phylogenetic analysis still needs to be widely tested, using different molecular data sets and taxonomic groups, and, also, by comparing complex networks approach to current methods in phylogenetic analysis. In this work, we compare all the four main methods of phylogenetic analysis (distance, maximum parsimony, maximum likelihood, and Bayesian) with a complex networks method that has been used to provide a phylogenetic classification based on a large number of protein sequences as those related to the chitin metabolic pathway and ATP-synthase subunits...
2018: PeerJ
https://www.readbyqxmd.com/read/29440626/upper-bound-dose-values-for-meson-radiation-in-heavy-ion-therapy
#9
Carolina Rabin, Marcello Gomes Gonçalves, Sergio Barbosa Duarte, Gabriel Gonzalez Sprinberg
Radiation treatments of cancer have evolved to include massive particle beams, instead of traditional irradiation procedures. Thus patient doses and workers radiological protection became issues of constant concern for these new technologies, especially for proton- and heavy-ion-therapy. In beam energies of interest of heavy-ion-therapy, secondary particle radiation comes from proton, neutron and neutral and charged pions produced in the nuclear collisions of the beam with human tissue atoms. This work, for the first time, offers the upper bound of meson radiation dose in organic tissues due to secondary meson radiation in heavy-ion therapy...
February 14, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29440369/fetal-and-maternal-innate-immunity-receptors-have-opposing-effects-in-severity-of-experimental-malaria-in-pregnancy-beneficial-roles-for-fetal-derived-tlr4-and-ifnar1
#10
Lurdes Rodrigues-Duarte, Yash Pandya, Rita Neres, Carlos Penha-Gonçalves
Malaria in Pregnancy (MiP) is a distinctive clinical form of Plasmodium infection and is a cause of placental insufficiency leading to poor pregnancy outcomes of pregnancy Maternal innate immunity responses play a decisive role in the development of placental inflammation but the action of fetal-derived factors in MiP outcomes has been overlooked. We investigated the role of Tlr4 and Ifnar1 genes taking advantage of heterogenic mating strategies to dissect the effects mediated by maternal and fetal-derived TLR4 or IFNAR1...
February 12, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29439621/biofluid-metabolomics-in-preterm-birth-research
#11
Ana M Gil, Daniela Duarte
This article presents an account of the research carried out so far in the use of metabolomics to find biomarkers of preterm birth (PTB) in fetal, maternal, and newborn biofluids. Metabolomic studies have employed mainly nuclear magnetic resonance spectroscopy or mass spectrometry-based methodologies to analyze, on one hand, prenatal biofluids (amniotic fluid, maternal urine/maternal blood, cervicovaginal fluid) to identify predictive biomarkers of PTB, and on the other hand, biofluids collected at or after birth (amniotic fluid, umbilical cord blood, newborn urine, and newborn blood, maternal blood, or breast milk) to assess and follow up the health status of PTB babies...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439574/model-based-evaluation-of-n2o-production-pathways-in-the-anammox-enriched-granular-sludge-cultivated-in-a-sequencing-batch-reactor
#12
Xi Lu, Tiago Duarte Santos Pereira, Hussein Alhazmi, Joanna Majtacz, Qi Zhou, Li Xie, Jacek Makinia
A mechanistic model was developed as an extension of the Activated Sludge Model No. 1 to describe three nitrous oxide (N2O) production pathways in a laboratory-scale anammox-enriched granular sequencing batch reactor. Heterotrophic denitrification and two processes mediated by ammonia oxidizing bacteria (AOB), i.e. ammonia (NH4+) oxidation via hydroxylamine (NH2OH) and autotrophic denitrification, were considered. A systematic model calibration and validation protocol was developed to obtain a unique set of kinetic parameters in the extended model...
February 13, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29437913/comparison-of-different-histological-indexes-in-the-assessment-of-uc-activity-and-their-accuracy-regarding-endoscopic-outcomes-and-faecal-calprotectin-levels
#13
Fernando Magro, Joanne Lopes, Paula Borralho, Susana Lopes, Rosa Coelho, José Cotter, Francisca Dias de Castro, Helena Tavares de Sousa, Marta Salgado, Patrícia Andrade, Ana Isabel Vieira, Pedro Figueiredo, Paulo Caldeira, A Sousa, Maria A Duarte, Filipa Ávila, João Silva, Joana Moleiro, Sofia Mendes, Sílvia Giestas, Paula Ministro, Paula Sousa, Raquel Gonçalves, Bruno Gonçalves, Ana Oliveira, Isadora Rosa, Marta Rodrigues, Cristina Chagas, Cláudia Camila Dias, Joana Afonso, Karel Geboes, Fátima Carneiro
OBJECTIVE: Histological remission is being increasingly acknowledged as a therapeutic endpoint in patients with UC. The work hereafter described aimed to evaluate the concordance between three histological classification systems-Geboes Score (GS), Nancy Index (NI) and RobartsHistopathologyIndex (RHI), as well as to evaluate their association with the endoscopic outcomes and the faecal calprotectin (FC) levels. DESIGN: Biopsy samples from 377 patients with UC were blindly evaluated using GS, NI and RHI...
February 3, 2018: Gut
https://www.readbyqxmd.com/read/29437811/giant-granadilla-s-seeds-phytobezoar-rectal-impactation-a-very-unusual-case-of-intestinal-obstruction
#14
André Rosa Alexandre, Luís Duarte Costa, Pedro Raimundo
A 78-year-old Caucasian man presented to the emergency department with bloody diarrhoea, diffuse abdominal pain and fever with 1-week duration. He had just returned from Angola where he had been treated for a presumed Clostridium difficile infection without improvement. He had no relevant medical or familiar history except for hypertension and prostate benign hyperplasia. He was drowsy, feverish and eupnoeic. His oxygen saturation on pulse oximetry was 92%, blood pressure was 173/99 mm Hg and pulse rate 100 beats per minute...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437539/genotoxicity-of-turnera-subulata-and-spondias-mombin%C3%A2-%C3%A3-%C3%A2-spondias-tuberosa-extracts-from-brazilian-caatinga-biome
#15
Tiago Felipe Senes-Lopes, Jorge Alberto López, Viviane Souza do Amaral, José Brandão-Neto, Adriana Augusto de Rezende, Jefferson Romáryo Duarte da Luz, Zaira da Rosa Guterres, Maria das Graças Almeida
Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. The experiments were performed using standard and high-bioactivation cross and three concentrations of the test substance [aqueous extract (AET and AES) at 5...
February 13, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29432378/low-perfusion-pressure-is-associated-with-renal-tubular-injury-in-infants-undergoing-cardiac-surgery-with-cardiopulmonary-bypass-a-secondary-analysis-of-an-observational-study
#16
Mirela Bojan, Maria C Basto Duarte, Vanessa Lopez, Laurent Tourneur, Stephanie Vicca, Marc Froissart
BACKGROUND: Earlier work on adults undergoing surgery with cardiopulmonary bypass suggests that there is a close relationship between the lower limit of the cerebral and renal autoregulation pressures. Although cerebral autoregulation during bypass in infants has been extensively investigated, the impact of bypass on kidney function is not well known. It is, nevertheless, acknowledged that the main pathophysiological process involved in cardiac surgery-related kidney damage is tubular injury, and that urine neutrophil gelatinase-associated lipocaline (uNGAL) is a reliable biomarker of injury...
February 9, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29432326/exercise-improves-physical-activity-and-comorbidities-in-obese-adults-with-asthma
#17
Patrícia Duarte Freitas, Aline Grandi Silva, Palmira Gabriele Ferreira, Analuci da Silva, João Marcos Salge, Regina Maria Carvalho-Pinto, Alberto Cukier, Claudia M Brito, Marcio C Mancini, Celso R F Carvalho
INTRODUCTION: Obese adults with asthma have an increased number of comorbidities and reduced daily life physical activity (DLPA), which may worsen asthma symptoms. Exercise is recommended to improve asthma outcomes; however, the benefits of exercise for psychosocial comorbidities and physical activity levels in obese adults with asthma have been poorly investigated. OBJECTIVE: To assess the effects of exercise on DLPA, asthma symptoms and psychosocial comorbidities in obese adults with asthma...
February 9, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29432325/let-the-pleasure-guide-your-resistance-training-intensity
#18
Hassan Mohamed Elsangedy, Daniel Gomes da Silva Machado, Kleverton Krinski, Paulo Henrique Duarte do Nascimento, Gledson Tavares de Amorim Oliveira, Tony Meireles Santos, Elaine A Hargreaves, Gaynor Parfitt
PURPOSE: The purpose of this study was to evaluate the feasibility and reliability of the Feeling Scale (FS) to self-regulate resistance training (RT) intensity. METHODS: Sixteen sedentary men (39.7±7.5 years) performed 3 familiarization sessions, 2 one repetition maximum testing (1RM), and 16 RT sessions (4 sessions for each FS descriptor; randomized). The FS descriptors were "very good" (FS+5), "good" (FS+3), "fairly good" (FS+1), and "fairly bad" (FS-1). Resistance exercises were leg press, chest press, knee extension, and seated biceps curl...
February 9, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29431478/high-intensity-interval-training-improves-inflammatory-and-adipokine-profiles-in-postmenopausal-women-with-metabolic-syndrome
#19
Flávia Mariel Steckling, Juliano Boufleur Farinha, Felipe da Cunha Figueiredo, Daniela Lopes Dos Santos, Guilherme Bresciani, Nélson Alexandre Kretzmann, Sílvio Terra Stefanello, Aline Alves Courtes, Maristela de Oliveira Beck, Manuela Sangoi Cardoso, Marta Maria Medeiros Frescura Duarte, Rafael Noal Moresco, Félix Alexandre Antunes Soares
This study investigate the effects of high-intensity interval training (HIIT) on systemic levels of inflammatory and hormonal markers in postmenopausal women with metabolic syndrome (MS). Fifteen postmenopausal women with MS completed the training on treadmills. Functional, body composition parameters, maximal oxygen uptake (VO 2 max), and lipid profile were assessed before and after HIIT. Serum or plasma levels of cytokines and hormonal markers were measured along the intervention. The analysis of messenger RNA (mRNA) expression of these cytokines was performed in peripheral blood mononuclear cells (PBMC)...
February 12, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29429122/optimal-control-approach-for-establishing-wmelpop-wolbachia-infection-among-wild-aedes-aegypti-populations
#20
Doris E Campo-Duarte, Olga Vasilieva, Daiver Cardona-Salgado, Mikhail Svinin
Wolbachia-based biocontrol has recently emerged as a potential method for prevention and control of dengue and other vector-borne diseases. Major vector species, such as Aedes aegypti females, when deliberately infected with Wolbachia become less capable of getting viral infections and transmitting the virus to human hosts. In this paper, we propose an explicit sex-structured population model that describes an interaction of uninfected (wild) male and female mosquitoes and those deliberately infected with wMelPop strain of Wolbachia in the same locality...
February 10, 2018: Journal of Mathematical Biology
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