keyword
https://read.qxmd.com/read/38454429/enhancing-cardiometabolic-health-unveiling-the-synergistic-effects-of-high-intensity-interval-training-with-spirulina-supplementation-on-selected-adipokines-insulin-resistance-and-anthropometric-indices-in-obese-males
#1
JOURNAL ARTICLE
Maryam Delfan, Ayoub Saeidi, Rashmi Supriya, Kurt A Escobar, Ismail Laher, Katie M Heinrich, Katja Weiss, Beat Knechtle, Hassane Zouhal
This study investigated the combined effects of 12 weeks of high-intensity interval training (HIIT) and spirulina supplementation on adipokine levels, insulin resistance, anthropometric indices, and cardiorespiratory fitness in 44 obese males (aged 25-40 years). The participants were randomly assigned to one of four groups: control (CG), supplement (SG), training (TG), or training plus supplement (TSG). The intervention involved daily administration of either spirulina or a placebo and HIIT three times a week for the training groups...
March 7, 2024: Nutrition & Metabolism
https://read.qxmd.com/read/38398877/anti-glycation-properties-of-zinc-enriched-arthrospira-platensis-spirulina-contribute-to-prevention-of-metaflammation-in-a-diet-induced-obese-mouse-model
#2
JOURNAL ARTICLE
Eleonora Aimaretti, Elisa Porchietto, Giacomo Mantegazza, Giorgio Gargari, Debora Collotta, Giacomo Einaudi, Gustavo Ferreira Alves, Enrica Marzani, Alessandro Algeri, Federica Dal Bello, Manuela Aragno, Carlo Cifani, Simone Guglielmetti, Raffaella Mastrocola, Massimo Collino
Advanced glycation end products (AGEs) exert a key pathogenic role in the development of obesity and insulin resistance. Thanks to its abundance in bioactive compounds, the microalga Arthrospira platensis (spirulina, SP) is proposed as a nutritional supplement. Here, we investigated the potential anti-glycating properties of SP enriched with zinc (Zn-SP) and the following impact on diet-induced metabolic derangements. Thirty male C57Bl6 mice were fed a standard diet (SD) or a high-fat high-sugar diet (HFHS) for 12 weeks, and a subgroup of HFHS mice received 350 mg/kg Zn-SP three times a week...
February 17, 2024: Nutrients
https://read.qxmd.com/read/38251049/the-effects-of-spirulina-supplementation-on-cardiometabolic-risk-factors-a-narrative-review
#3
REVIEW
Sara Sokary, Hiba Bawadi, Zain Zaki Zakaria, Maha Al-Asmakh
Spirulina ( Arthrospira platensis) is a cyanobacterium associated with multiple health benefits. Cardiometabolic diseases such as cardiovascular disease, nonalcoholic fatty liver disease, and diabetes are prevalent yet usually preventable non-communicable diseases. Modifiable risk factors for cardiometabolic diseases include excessive body weight, body inflammation, atherogenic lipid profile, and imbalanced glucose metabolism. This review explores the effects of spirulina on cardiometabolic diseases risk factors...
January 22, 2024: Journal of Dietary Supplements
https://read.qxmd.com/read/36861852/the-effects-of-spirulina-intake-on-clinical-and-metabolic-parameters-in-alzheimer-s-disease-a-randomized-double-blind-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Omid Reza Tamtaji, Reza Heidari-Soureshjani, Zatollah Asemi, Ebrahim Kouchaki
The current study aimed to determine the effects of spirulina intake on cognitive function and metabolic status among patients with Alzheimer's disease (AD). This randomized, double-blind, controlled clinical trial was done among 60 subjects with AD. Patients were randomly assigned to receive either 500 mg/day spirulina or a placebo (each n = 30) twice a day for 12 weeks. Mini-mental state examination score (MMSE) was recorded in all patients before and after intervention. Blood samples were obtained at baseline and after 12 weeks' intervention to determine metabolic markers...
July 2023: Phytotherapy Research: PTR
https://read.qxmd.com/read/35873798/ameliorating-effect-on-glycolipid-metabolism-of-spirulina-functional-formulation-combination-from-traditional-chinese-medicine
#5
JOURNAL ARTICLE
Zifeng Huang, Chang'e Wang, Jie Chen, Xiaoyu He, Kewen Chen, Xiaoqin Jiang, Chao Zhao, Bin Liu
Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects. Therefore, there is an urgent need to search for safe and natural foods that do not cause adverse effects as alternatives to commercial drugs. In this study, the active substances from Spirulina platensis , Grifola frondosa , Panax ginseng , and chromium-rich yeast were used to obtain Spirulina functional formulations (SFFs), and its therapeutic effects on mice with glycolipid metabolism disorder (GLD) were investigated...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/34948230/it-is-high-time-physicians-thought-of-natural-products-for-alleviating-nafld-is-there-sufficient-evidence-to-use-them
#6
REVIEW
Giovanni Tarantino, Clara Balsano, Silvano Junior Santini, Giovanni Brienza, Irma Clemente, Benedetta Cosimini, Gaia Sinatti
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease all over the world due to the obesity pandemic; currently, therapeutic options for NAFLD are scarce, except for diet recommendations and physical activity. NAFLD is characterized by excessive accumulation of fat deposits (>5%) in the liver with subsequent inflammation and fibrosis. Studies in the literature show that insulin resistance (IR) may be considered as the key mechanism in the onset and progression of NAFLD. Recently, using natural products as an alternative approach in the treatment of NAFLD has drawn growing attention among physicians...
December 14, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34616107/-spirulina-platensis-and-its-ingredient-biopterin-glucoside-improved-insulin-sensitivity-in-non-alcoholic-steatohepatitis-model
#7
JOURNAL ARTICLE
Yuri Fujihara, Yasumasa Kodo, Shin-Ichi Miyoshi, Ritsuko Watanabe, Hiroshi Toyoda, Mitsumasa Mankura, Hideaki Kabuto, Fusako Takayama
Non-alcoholic steatohepatitis is the chronic liver disease leading to cirrhosis and cancer and its prevalence is increasing. Some agents are under clinical trials for non-alcoholic steatohepatitis treatment. We previously reported Spirulina (Arthrospira) platensis effectively prevented non-alcoholic steatohepatitis progression in our model rats. The contribution of phycocyanin, an ingredient of Spirulina (Arthrospira) platensis , was limited. We, therefore, have looked for more active components of Spirulina (Arthrospira) platensis ...
September 2021: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/34538515/effect-of-microalgae-arthrospira-on-biomarkers-of-glycemic-control-and-glucose-metabolism-a-systematic-review-and-meta-analysis
#8
REVIEW
Fahimeh Ghanbari, Atefeh Amerizadeh, Parisa Behshood, Sajjad Moradi, Sedigheh Asgary
Diabetes mellitus and insulin resistance are associated with an increased risk of cardiovascular disease (CVD) incidence and a higher rate of CVD-related death. In this study, the effects of Arthrospira (Spirulina) a blue-green algae supplementation on biomarkers of glycemic control and glucose metabolism has been evaluated. PubMed, Scopus, and ISI Web of Science were searched systematically of English human subjects and PubMed for pre-clinical animal studies (rats and mice) from January 2008 until November 2020...
July 24, 2021: Current Problems in Cardiology
https://read.qxmd.com/read/33572056/edible-microalgae-and-their-bioactive-compounds-in-the-prevention-and-treatment-of-metabolic-alterations
#9
REVIEW
Sara Ramos-Romero, Joan Ramon Torrella, Teresa Pagès, Ginés Viscor, Josep Lluís Torres
Marine and freshwater algae and their products are in growing demand worldwide because of their nutritional and functional properties. Microalgae (unicellular algae) will constitute one of the major foods of the future for nutritional and environmental reasons. They are sources of high-quality protein and bioactive molecules with potential application in the modern epidemics of obesity and diabetes. They may also contribute decisively to sustainability through carbon dioxide fixation and minimization of agricultural land use...
February 9, 2021: Nutrients
https://read.qxmd.com/read/33348926/are-there-any-beneficial-effects-of-spirulina-supplementation-for-metabolic-syndrome-components-in-postmenopausal-women
#10
REVIEW
Elena Bobescu, Andreea Bălan, Marius Alexandru Moga, Andreea Teodorescu, Maria Mitrică, Lorena Dima
Spirulina is a phytosynthetic filamentous cyanobacterium with microscopic dimensions, which naturally grows in the highly-salted alkaline lakes of Africa, Mexico, America, and Asia. Several bioactive peptides extracted from Spirulina were demonstrated to possess antimicrobial, antiviral, antitumor, immunomodulatory, antiallergic and antihypertensive properties. It has been reported that the consumption of Spirulina could prevent or manage metabolic syndrome components. In women, metabolic disorders are more prevalent during menopause...
December 17, 2020: Marine Drugs
https://read.qxmd.com/read/32795119/omeprazole-and-spirulina-platensis-ameliorate-steatohepatitis-in-experimental-nonalcoholic-fatty-liver-disease
#11
JOURNAL ARTICLE
Noha A El-Boghdady, Maher A Kamel, Rouaina M El-Shamy
Background: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage, and it affects about 24% of the population worldwide. This study aimed to investigate the effect of omeprazole and Spirulina platensis on hepatic and serum biochemical alterations in NAFLD induced by high-fat diet (HFD). Methods: Male Wistar rats were divided into four groups; one served as a normal control. The other groups received HFD and subdivided into three subgroups; one was left untreated and the other two groups were treated orally with either omeprazole (10 mg/kg) or Spirulina (1000 mg/kg) for 30 consecutive days...
August 13, 2020: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/32207345/spirulina-reduces-diet-induced-obesity-through-downregulation-of-lipogenic-genes-expression-in-psammomys-obesus
#12
JOURNAL ARTICLE
Hamza Saidi, Abdenour Bounihi, Asma Bouazza, Aziz Hichami, El Hadj Ahmed Koceir, Naim Akhtar Khan
The present study evaluates the protective effect of spirulina against diet-induced obesity and metabolic disorders in Psammomys obesus , an animal model of metabolic syndrome. Psammomys obesus lives on a low-energy diet, in order to remain healthy. However, under a standard laboratory chow diet (SLCD), this animal exhibits insulin resistance, which occurs as a result of obesity. Psammomys obesus was maintained on SLCD, in order to evaluate the effect of spirulina on obesity development with a particular focus on glucose and lipid metabolism, as well as the mRNA expression of some pro-inflammatory cytokines...
March 24, 2020: Archives of Physiology and Biochemistry
https://read.qxmd.com/read/31861663/anti-obesity-effects-of-microalgae
#13
REVIEW
Saioa Gómez-Zorita, Jenifer Trepiana, Maitane González-Arceo, Leixuri Aguirre, Iñaki Milton-Laskibar, Marcela González, Itziar Eseberri, Alfredo Fernández-Quintela, María P Portillo
In recent years, microalgae have attracted great interest for their potential applications in nutraceutical and pharmaceutical industry as an interesting source of bioactive medicinal products and food ingredients with anti-oxidant, anti-inflammatory, anti-cancer, and anti-microbial properties. One potential application for bioactive microalgae compounds is obesity treatment. This review gathers together in vitro and in vivo studies which address the anti-obesity effects of microalgae extracts. The scientific literature supplies evidence supporting an anti-obesity effect of several microalgae: Euglena gracilis , Phaeodactylum tricornutum , Spirulina maxima , Spirulina platensis , or Nitzschia laevis ...
December 19, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/29693104/c-phycocyanin-inhibits-hepatic-gluconeogenesis-and-increases-glycogen-synthesis-via-activating-akt-and-ampk-in-insulin-resistance-hepatocytes
#14
JOURNAL ARTICLE
Zhiheng Ren, Zhifei Xie, Danni Cao, Mufeng Gong, Lei Yang, Zhu Zhou, Yu Ou
C-Phycocyanin (C-PC), a kind of blue protein isolated from Spirulina platensis, can ameliorate hyperglycemia, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of C-PC on gluconeogenesis and glycogenesis in insulin resistant hepatocytes. Insulin resistance was induced by high glucose (HG) in human hepatocellular carcinoma (HepG2) cells. C-PC ameliorated glucose production and phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression in HG-induced insulin resistant HepG2 cells...
May 23, 2018: Food & Function
https://read.qxmd.com/read/28771165/spirulina-platensis-improves-mitochondrial-function-impaired-by-elevated-oxidative-stress-in-adipose-derived-mesenchymal-stromal-cells-ascs-and-intestinal-epithelial-cells-iecs-and-enhances-insulin-sensitivity-in-equine-metabolic-syndrome-ems-horses
#15
JOURNAL ARTICLE
Daria Nawrocka, Katarzyna Kornicka, Agnieszka Śmieszek, Krzysztof Marycz
Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation. Inflammatory microenvironment of adipose tissue constitutes the direct tissue milieu for various cell populations, including adipose-derived mesenchymal stromal cells (ASCs), widely considered as a potential therapeutic cell source in the course of the treatment of metabolic disorders. Moreover, elevated oxidative stress induces inflammation in intestinal epithelial cells (IECs)-the first-line cells exposed to dietary compounds...
August 3, 2017: Marine Drugs
https://read.qxmd.com/read/27069726/spirulina-versicolor-improves-insulin-sensitivity-and-attenuates-hyperglycemia-mediated-oxidative-stress-in-fructose-fed-rats
#16
JOURNAL ARTICLE
Walaa G Hozayen, Ayman M Mahmoud, Hanan A Soliman, Sanura R Mostafa
AIM: The current study aimed to investigate the anti-hyperglycemic, anti-hyperlipidemic and insulin sensitizing effects of the cyanobacterium Spirulina versicolor extract in fructose-fed rats. MATERIALS AND METHODS: Rats were fed 30% fructose solution in drinking water for 4 weeks. Animals exhibited hyperglycemia and hyperinsulinemia were selected for further investigations. Diabetic and control rats were orally supplemented with 50 mg/kg body weight S. versicolor extract for 4 weeks...
January 2016: Journal of Intercultural Ethnopharmacology
https://read.qxmd.com/read/26475369/glucomannan-and-glucomannan-plus-spirulina-added-to-pork-significantly-block-dietary-cholesterol-effects-on-lipoproteinemia-arylesterase-activity-and-cyp7a1-expression-in-zucker-fa-fa-rats
#17
JOURNAL ARTICLE
Laura González-Torres, Miguel Vázquez-Velasco, Raúl Olivero-David, Sara Bastida, Juana Benedí, Rafaela Raposo González, Ma José González-Muñoz, Francisco J Sánchez-Muniz
Zucker fa/fa rats easily develop dyslipidemia and obesity. Restructured pork (RP) is a suitable matrix for including functional ingredients. The effects of glucomannan- RP or glucomannan plus spirulina-enriched RP on plasma lipid/lipoprotein levels, cytochrome P450 7A1 (CYP7A1) expression, and arylesterase activity in growing fa/fa rats fed high-energy, high-fat cholesterol-enriched diets were tested. Groups of six rats each received diet containing 15% control-RP (C), 15% glucomannan-RP diet (G), 15% glucomannan + spirulina-RP diet (GS), and same diets enriched with 2...
December 2015: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/26233874/dietary-silicon-enriched-spirulina-improves-early-atherosclerosis-markers-in-hamsters-on-a-high-fat-diet
#18
JOURNAL ARTICLE
Joris Vidé, Anne Virsolvy, Cindy Romain, Jeanne Ramos, Nicolas Jouy, Sylvain Richard, Jean-Paul Cristol, Sylvie Gaillet, Jean-Max Rouanet
OBJECTIVE: The aim of this study was to investigate the effects of dietary silicon-enriched spirulina (SES) on atherosclerosis. METHODS: Hamsters (six per group) on a high-fat (HF) diet received SES or non-enriched spirulina (both at 57 mg/kg body weight) daily. This corresponded to 0.57 mg silicon/kg body weight daily. RESULTS: The HF diet induced dyslipidemia, insulin resistance, oxidative stress, and vascular dysfunction. Compared with the HF group, SES attenuated increases of lipemia and prevented insulin resistance (IR) (P = 0...
September 2015: Nutrition
https://read.qxmd.com/read/25496727/effects-of-spirulina-platensis-supplementation-on-lipid-profile-in-hiv-infected-antiretroviral-na%C3%A3-ve-patients-in-yaounde-cameroon-a-randomized-trial-study
#19
RANDOMIZED CONTROLLED TRIAL
Marthe-Elise Ngo-Matip, Constant Anatole Pieme, Marcel Azabji-Kenfack, Prosper Cabral Nya Biapa, Nkenfack Germaine, Englert Heike, Bruno Moukette Moukette, Korosky Emmanuel, Stefanini Philippe, Carl Moses Mbofung, Jeanne Yonkeu Ngogang
BACKGROUND: Cardiovascular diseases (CVD) and metabolic alterations are among the majors public health concern that have been reported in people living with HIV infections. Factors contributing to cardio metabolic syndrome in HIV include body fat distribution, dyslipidemia, insulin resistance, cardiovascular dysfunction and inflammation. The aim of the study was to determine the effect of Spirulina platensis (Cyanobacteriaceae) supplementation versus local diet on lipid profile in HIV-infected antiretroviral-naive patients...
December 13, 2014: Lipids in Health and Disease
https://read.qxmd.com/read/25331487/the-hepatoprotective-and-hypolipidemic-effects-of-spirulina-arthrospira-platensis-supplementation-in-a-cretan-population-with-non-alcoholic-fatty-liver-disease-a-prospective-pilot-study
#20
JOURNAL ARTICLE
Elias E Mazokopakis, Maria G Papadomanolaki, Andreas A Fousteris, Dimitrios A Kotsiris, Ioannis M Lampadakis, Emmanuel S Ganotakis
BACKGROUND: A pilot study was conducted to determine the effects of Spirulina (Arthrospira platensis) on Cretan patients with non-alcoholic fatty liver disease (NAFLD). Spirulina is a filamentous cyanobacterium taken as a dietary supplement. METHODS: Fifteen adult Cretan outpatients (13 men), median age 48 (range: 29-62) years, with NAFLD were orally supplemented with 6 g of Spirulina (Greek production) per day for six months. Anthropometric characteristics (height, weight, waist circumference), systolic and diastolic blood pressure, complete blood count, biochemical assessments, homeostasis model assessment of insulin resistance (HOMA-IR) index, health-related quality of life and abdominal sonographic findings were recorded and measured, before and after Spirulina supplementation...
2014: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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