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spirulina in insuline resistence

Zhiheng Ren, Zhifei Xie, Danni Cao, Mufeng Gong, Lei Yang, Zhu Zhou, Yu Ou
C-Phycocyanin (C-PC), a kind of blue protein isolated from Spirulina platensis, can ameliorate hyperglycemia, but its effects on gluconeogenesis and glycogenesis are unknown. In the present study, we investigated the effects and underlying mechanisms of C-PC on gluconeogenesis and glycogenesis in insulin resistant hepatocytes. Insulin resistance was induced by high glucose (HG) in human hepatocellular carcinoma (HepG2) cells. C-PC ameliorated glucose production and phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) expression in HG-induced insulin resistant HepG2 cells...
May 23, 2018: Food & Function
Daria Nawrocka, Katarzyna Kornicka, Agnieszka Śmieszek, Krzysztof Marycz
Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation. Inflammatory microenvironment of adipose tissue constitutes the direct tissue milieu for various cell populations, including adipose-derived mesenchymal stromal cells (ASCs), widely considered as a potential therapeutic cell source in the course of the treatment of metabolic disorders. Moreover, elevated oxidative stress induces inflammation in intestinal epithelial cells (IECs)-the first-line cells exposed to dietary compounds...
August 3, 2017: Marine Drugs
Walaa G Hozayen, Ayman M Mahmoud, Hanan A Soliman, Sanura R Mostafa
AIM: The current study aimed to investigate the anti-hyperglycemic, anti-hyperlipidemic and insulin sensitizing effects of the cyanobacterium Spirulina versicolor extract in fructose-fed rats. MATERIALS AND METHODS: Rats were fed 30% fructose solution in drinking water for 4 weeks. Animals exhibited hyperglycemia and hyperinsulinemia were selected for further investigations. Diabetic and control rats were orally supplemented with 50 mg/kg body weight S. versicolor extract for 4 weeks...
January 2016: Journal of Intercultural Ethnopharmacology
Laura González-Torres, Miguel Vázquez-Velasco, Raúl Olivero-David, Sara Bastida, Juana Benedí, Rafaela Raposo González, Ma José González-Muñoz, Francisco J Sánchez-Muniz
Zucker fa/fa rats easily develop dyslipidemia and obesity. Restructured pork (RP) is a suitable matrix for including functional ingredients. The effects of glucomannan- RP or glucomannan plus spirulina-enriched RP on plasma lipid/lipoprotein levels, cytochrome P450 7A1 (CYP7A1) expression, and arylesterase activity in growing fa/fa rats fed high-energy, high-fat cholesterol-enriched diets were tested. Groups of six rats each received diet containing 15% control-RP (C), 15% glucomannan-RP diet (G), 15% glucomannan + spirulina-RP diet (GS), and same diets enriched with 2...
December 2015: Journal of Physiology and Biochemistry
Joris Vidé, Anne Virsolvy, Cindy Romain, Jeanne Ramos, Nicolas Jouy, Sylvain Richard, Jean-Paul Cristol, Sylvie Gaillet, Jean-Max Rouanet
OBJECTIVE: The aim of this study was to investigate the effects of dietary silicon-enriched spirulina (SES) on atherosclerosis. METHODS: Hamsters (six per group) on a high-fat (HF) diet received SES or non-enriched spirulina (both at 57 mg/kg body weight) daily. This corresponded to 0.57 mg silicon/kg body weight daily. RESULTS: The HF diet induced dyslipidemia, insulin resistance, oxidative stress, and vascular dysfunction. Compared with the HF group, SES attenuated increases of lipemia and prevented insulin resistance (IR) (P = 0...
September 2015: Nutrition
Marthe-Elise Ngo-Matip, Constant Anatole Pieme, Marcel Azabji-Kenfack, Prosper Cabral Nya Biapa, Nkenfack Germaine, Englert Heike, Bruno Moukette Moukette, Korosky Emmanuel, Stefanini Philippe, Carl Moses Mbofung, Jeanne Yonkeu Ngogang
BACKGROUND: Cardiovascular diseases (CVD) and metabolic alterations are among the majors public health concern that have been reported in people living with HIV infections. Factors contributing to cardio metabolic syndrome in HIV include body fat distribution, dyslipidemia, insulin resistance, cardiovascular dysfunction and inflammation. The aim of the study was to determine the effect of Spirulina platensis (Cyanobacteriaceae) supplementation versus local diet on lipid profile in HIV-infected antiretroviral-naive patients...
December 13, 2014: Lipids in Health and Disease
Elias E Mazokopakis, Maria G Papadomanolaki, Andreas A Fousteris, Dimitrios A Kotsiris, Ioannis M Lampadakis, Emmanuel S Ganotakis
BACKGROUND: A pilot study was conducted to determine the effects of Spirulina (Arthrospira platensis) on Cretan patients with non-alcoholic fatty liver disease (NAFLD). Spirulina is a filamentous cyanobacterium taken as a dietary supplement. METHODS: Fifteen adult Cretan outpatients (13 men), median age 48 (range: 29-62) years, with NAFLD were orally supplemented with 6 g of Spirulina (Greek production) per day for six months. Anthropometric characteristics (height, weight, waist circumference), systolic and diastolic blood pressure, complete blood count, biochemical assessments, homeostasis model assessment of insulin resistance (HOMA-IR) index, health-related quality of life and abdominal sonographic findings were recorded and measured, before and after Spirulina supplementation...
2014: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Annu Gupta, Anroop Nair, Rachna Kumria, Bandar-E Al-Dhubiab, Ipshita Chattopadhyaya, Sumeet Gupta
The objective of the current study was to assess the possible pharmacokinetic interactions of spirulina with glitazones in an insulin resistance rat model. Wistar male albino rats were equally divided into five groups: insulin resistant rats+spirulina (500 mg/kg)+pioglitazone (10 mg/kg), insulin resistant rats+pioglitazone (10 mg/kg), insulin resistant rats+spirulina (500 mg/kg)+rosiglitazone (10 mg/kg), insulin resistant rats+rosiglitazone (10 mg/kg), and insulin resistant rats+spirulina (500 mg/kg). Described doses of pioglitazone, rosiglitazone, or spirulina were per orally administered and the plasma drug concentrations were determined...
December 2013: Journal of Medicinal Food
Yu Ou, Lin Lin, Xuegan Yang, Qin Pan, Xiaodong Cheng
CONTEXT: Phycocyanin (PC) has been proven to have many therapeutic properties, but its effects on diabetes have not been investigated. OBJECTIVE: Antidiabetic activity of PC isolated from Spirulina platensis was evaluated in this study. MATERIALS AND METHODS: Oral administration of PC (100 mg/kg, once per day for 3 weeks) on KKAy mice were investigated by monitoring the changes in body weight, food intake, fasting plasma glucose level, 24 h random blood glucose levels, oral glucose tolerance tests (OGTTs), glycosylated serum protein (GSP), fasting serum insulin (FINS), glycogen, triglyceride (TG), total cholesterol (TC), total antioxidative capability (T-AOC) and malondialdehyde (MDA)...
May 2013: Pharmaceutical Biology
Chai Siah Ku, Tho X Pham, Youngki Park, Bohkyung Kim, Min Sun Shin, Insoo Kang, Jiyoung Lee
BACKGROUND: Chronic inflammation contributes to the development of pathological disorders including insulin resistance and atherosclerosis. Identification of anti-inflammatory natural products can prevent the inflammatory diseases. METHODS: Anti-inflammatory effects of blue-green algae (BGA), i.e., Nostoc commune var. sphaeroides Kützing (NO) and Spirulina platensis (SP), were compared in RAW 264.7 and mouse bone marrow-derived macrophages (BMM) as well as splenocytes from apolipoprotein E knockout (apoE(-/-)) mice fed BGA...
April 2013: Biochimica et Biophysica Acta
Patricia Victoria Torres-Durán, Aldo Ferreira-Hermosillo, Arnulfo Ramos-Jiménez, Rosa Patricia Hernández-Torres, Marco Antonio Juárez-Oropeza
Trained people exhibit low plasma concentrations of triacylglcyerols in both fasting and postprandial states. Exercise practice is commonly believed to improve postprandial lipemia. In addition, elevated postprandial lipemia is an indicator of poor lipid clearance, and it has been associated with atherosclerosis, insulin resistance, and obesity. Spirulina maxima is an edible microorganism with a high nutritional value. When it is consumed, beneficial properties to health have been demonstrated, such as hypolipemic and antihypertensive properties in human beings...
August 2012: Journal of Medicinal Food
Azabji-Kenfack Marcel, Loni G Ekali, Sobngwi Eugene, Onana E Arnold, Edie D Sandrine, Denis von der Weid, Emmanuel Gbaguidi, Jeanne Ngogang, Jean C Mbanya
UNLABELLED: HIV-infected patients develop abnormalities of glucose metabolism due to the virus and antiretroviral drugs. Spirulina and soybean are nutritional supplements that are cheap, accessible in our community and affect glucose metabolism. We carried out a randomized study to assess the effect of Spirulina platensis versus soybean as a food supplement on HIV/HAART-associated insulin resistance (IR) in 33 insulin-resistant HIV-infected patients. The study lasted for two months at the National Obesity Centre of Cameroon...
July 2011: Nutrients
Mark F McCarty
Owing to the worldwide epidemic of obesity, and the popularity of diets rich in sugar and saturated fat, nonalcoholic fatty liver disease (NAFLD) is increasingly common; it is usually associated with insulin resistance, and may be considered a component of the metabolic syndrome. The pathologies which can complicate hepatic steatosis--steatohepatitis, cirrhosis, and hepatic cancer--appear to result from an interaction of hepatic lipid overload and hepatic oxidative stress. It is therefore proposed that comprehensive regimens which effectively target each of these precipitating factors should achieve the best therapeutic benefit in NAFLD...
October 2011: Medical Hypotheses
Sumeet Gupta, H J Hrishikeshvan, Prabodh K Sehajpal
AIM: The study was undertaken to assess the protective effect of Spirulina fusiformis extract against Rosiglitazone induced osteoporosis and pharmacodynamic effects of Rosiglitazone with Spirulina in treating hyperglycemia and hyperlipidemia of insulin resistance rat. METHOD: For this aim, 30 Wistar albino rats were equally divided into five groups as control (C), diabetes mellitus (DM), diabetes mellitus+Rosiglitazone (DM+R), diabetes mellitus+Spirulina (DM+S), and diabetes mellitus+Rosiglitazone+Spirulina (DM+R+S)...
January 2010: Diabetes Research and Clinical Practice
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