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aerobic training asthma

Patricia D Freitas, Palmira G Ferreira, Aline G Silva, Rafael Stelmach, Regina M Carvalho-Pinto, Frederico L A Fernandes, Marcio C Mancini, Maria N Sato, Milton A Martins, Celso R F Carvalho
RATIONALE: Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight-loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated. OBJECTIVE: To examine the effect of exercise training in a weight-loss program on asthma control, quality of life, inflammatory biomarkers and lung function. METHODS: Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program + exercise (WL+E group, n=28) or a weight-loss program + sham (WL+S group, n=27) group, where the weight-loss program included nutrition (caloric restriction) and psychological therapies...
July 19, 2016: American Journal of Respiratory and Critical Care Medicine
Ricardo Wesley Alberca-Custódio, Flávia Regina Greiffo, BreAnne MacKenzie, Manoel Carneiro Oliveira-Junior, Adilson Santos Andrade-Sousa, Gustavo Silveira Graudenz, Angela Batista Gomes Santos, Nilsa Regina Damaceno-Rodrigues, Hugo Caire Castro-Faria-Neto, Fernanda Magalhaes Arantes-Costa, Milton De Arruda Martins, Asghar Abbasi, Chin Jia Lin, Marco Idzko, Ana Paula Ligeiro Oliveira, Hinnak Northoff, Rodolfo Paula Vieira
INTRODUCTION: Leukotrienes (LTs) play a central role in asthma. Low- to moderate-intensity aerobic exercise (AE) reduces asthmatic inflammation in clinical studies and in experimental models. This study investigated whether AE attenuates LT pathway activation in an ovalbumin (OVA) model of asthma. METHODS: Sixty-four male, BALB/c mice were distributed into Control, Exercise (Exe), OVA, and OVA + Exe groups. Treadmill training was performed at moderate intensity, 5×/week, 1 h/session for 4 weeks...
2016: Frontiers in Immunology
C C de Araújo, P S Marques, J D Silva, C S Samary, A L da Silva, I Henriques, M A Antunes, M V de Oliveira, R C Goldenberg, M M Morales, I Abreu, B L Diaz, N N Rocha, V L Capelozzi, P R M Rocco
Experimental studies have reported that aerobic exercise after asthma induction reduces lung inflammation and remodeling. Nevertheless, no experimental study has analyzed whether regular/moderate aerobic training before the induction of allergic asthma may prevent these inflammatory and remodeling processes. For this purpose, BALB/c mice (n = 96) were assigned into non-trained and trained groups. Trained animals ran on a motorized treadmill at moderate intensity, 30 min/day, 3 times/week, for 8 weeks, and were further randomized into subgroups to undergo ovalbumin sensitization and challenge or receive saline using the same protocol...
January 6, 2016: Scandinavian Journal of Medicine & Science in Sports
Shaw Bronner, Emma Codman, Dana Hash-Campbell, Sheyi Ojofeitimi
The aerobic demands of today's dance repertoire warrant understanding of the current cardiorespiratory fitness of dancers. The purpose of this study was to compare aerobic fitness levels of professional and pre-professional modern dancers and determine change over time. A retrospective analysis of four groups, two professional, and two pre-professional, was conducted in preseason annual screens, occurring before the professional dancers' rehearsal period and the students' academic training. Resting (HRrest), peak (HRpeak), and recovery (HRrecov) heart rate, and blood pressure (BP) were compared in 577 dancers, using an accelerated 3-minute step test...
March 2016: Journal of Dance Medicine & Science
Breanne Mackenzie, Adilson Santos Andrade-Sousa, Manoel Carneiro Oliveira-Junior, Erasmo Assumpção-Neto, Maysa Alves Rodrigues Brandão-Rangel, Adriano Silva-Renno, Alana Santos-Dias, Sanja Cicko, Melanie Grimm, Tobias Müller, Ana Paula Ligeiro Oliveira, Milton Arruda Martins, Marco Idzko, Rodolfo Paula Vieira
INTRODUCTION: This study investigated the effects of aerobic exercise (AE) on both the maturation of dendritic cells (DC) and the activation of lymphocytes in a mouse model of chronic allergic airway inflammation. METHODS: C57BL/6 mice distributed into control, exercise, ovalbumin (OVA), and OVA + exercise groups were submitted to OVA sensitization and challenge. Treadmill training was performed for 4 wk, and mice were assessed for classical features of chronic allergic airway inflammation as well as dendritic cell activation and T-lymphocyte response...
August 2016: Medicine and Science in Sports and Exercise
Stefano R Del Giacco, Vanessa Garcia-Larsen
No abstract text is available yet for this article.
April 2016: Evidence-based Medicine
Fabien Pillard, Michel Lavit, Valérie Lauwers Cances, Jacques Rami, Georges Houin, Alain Didier, Daniel Rivière
BACKGROUND: Salbutamol abuse detection by athletes is based on a urinary upper threshold defined by the World Anti-Doping Agency (WADA). However, this threshold was determined in healthy, untrained individuals and after a dose of salbutamol inhaled that might not really mirror the condition of asthmatic athletes and the experts's guidelines for asthma management. We aimed to revise this threshold in accordance with recommended clinical practice (that appear to be different from the actual WADA recommendation) and in exercise conditions...
2015: Respiratory Research
Patricia D Freitas, Palmira G Ferreira, Analuci da Silva, Sonia Trecco, Rafael Stelmach, Alberto Cukier, Regina Carvalho-Pinto, João Marcos Salge, Frederico L A Fernandes, Marcio C Mancini, Milton A Martins, Celso R F Carvalho
BACKGROUND: Asthma and obesity are public health problems with increasing prevalence worldwide. Clinical and epidemiologic studies have demonstrated that obese asthmatics have worse clinical control and health related quality of life (HRQL) despite an optimized medical treatment. Bariatric surgery is successful to weight-loss and improves asthma control; however, the benefits of nonsurgical interventions remain unknown. METHODS/DESIGN: This is a randomized controlled trial with 2-arms parallel...
2015: BMC Pulmonary Medicine
Evelim L F D Gomes, Celso R F Carvalho, Fabiana Sobral Peixoto-Souza, Etiene Farah Teixeira-Carvalho, Juliana Fernandes Barreto Mendonça, Roberto Stirbulov, Luciana Maria Malosá Sampaio, Dirceu Costa
OBJECTIVE: The aim of the present study was to determine whether aerobic exercise involving an active video game system improved asthma control, airway inflammation and exercise capacity in children with moderate to severe asthma. DESIGN: A randomized, controlled, single-blinded clinical trial was carried out. Thirty-six children with moderate to severe asthma were randomly allocated to either a video game group (VGG; N = 20) or a treadmill group (TG; n = 16). Both groups completed an eight-week supervised program with two weekly 40-minute sessions...
2015: PloS One
Mariana Mazzuca Reimberg, Rejane Agnelo Silva Castro, Jessyca Pachi Rodrigues Selman, Aline Santos Meneses, Fabiano Politti, Márcia Carvalho Mallozi, Gustavo Falbo Wandalsen, Dirceu Solé, Kátia De Angelis, Simone Dal Corso, Fernanda Cordoba Lanza
BACKGROUND: Individuals with chronic lung disease are more susceptible to present reduction in exercise tolerance and muscles strength not only due to pulmonary limitations but also due systemic repercussions of the pulmonary disease. The aim of this study is to assess the physical capacity, peripheral muscle function, physical activity in daily life, and the inflammatory markers in children and adolescents with asthma after pulmonary rehabilitation program. METHOD: This is a study protocol of randomized controlled trial in asthmatic patients between 6 to 18 years old...
2015: Trials
Mariana Couto, Paulo Santos, Diana Silva, Luís Delgado, André Moreira
BACKGROUND: Cooling of the airways and inflammation have been pointed as possible mechanisms for exercise-induced asthma (EIA). We aimed to investigate the effect of training and asthma on exhaled breath temperature (EBT) of elite swimmers. METHODS: Elite swimmers annually screened (skin prick tests, spirometry before and after salbutamol inhalation, induced sputum cell counts, and methacholine bronchial challenge) at our department (n = 27) were invited to this prospective study...
September 2015: Pediatric Allergy and Immunology
Andrezza França-Pinto, Felipe A R Mendes, Regina Maria de Carvalho-Pinto, Rosana Câmara Agondi, Alberto Cukier, Rafael Stelmach, Beatriz M Saraiva-Romanholo, Jorge Kalil, Milton A Martins, Pedro Giavina-Bianchi, Celso R F Carvalho
BACKGROUND: The benefits of aerobic training for the main features of asthma, such as bronchial hyperresponsiveness (BHR) and inflammation, are poorly understood. We investigated the effects of aerobic training on BHR (primary outcome), serum inflammatory cytokines (secondary outcome), clinical control and asthma quality of life (Asthma Quality of Life Questionnaire (AQLQ)) (tertiary outcomes). METHODS: Fifty-eight patients were randomly assigned to either the control group (CG) or the aerobic training group (TG)...
August 2015: Thorax
R A Silva, F M Almeida, C R Olivo, B M Saraiva-Romanholo, M A Martins, C R F Carvalho
The purpose of this study was to determine the effect of aerobic exercise training (AT) on the expression of glucocorticoid receptors (GR) and anti-inflammatory cytokines in an asthma model. BALB/c mice were divided into groups control (CT; nonsensitized/nontrained), aerobic training (AT; nonsensitized/trained), ovalbumin (OVA; sensitized/not trained), and OVA+AT (sensitized/trained). OVA groups received OVA by inhalation, and the AT groups completed 1, 3, or 7 days of exercise (60 min/session). Expression of GR, IL-4, IL-5, IL-10, IL-1ra, NF-κB, TGF-β, VEGF, ICAM-1, VCAM-1; eosinophils counting; and airway remodeling (AR) features [airway smooth muscle (ASM) and epithelial thickness and collagen fiber deposition] were quantified...
January 2016: Scandinavian Journal of Medicine & Science in Sports
Lívia Barboza de Andrade, Murilo C A Britto, Norma Lucena-Silva, Renan Garcia Gomes, José N Figueroa
Few studies have been conducted on the effects of aerobic exercise in children with asthma, particularly on the inflammatory component and functional outcomes. This study evaluated the effect of aerobic exercise on inflammation, functional capacity, respiratory muscle strength, quality of life and symptoms scores in asthmatic children. This was a 6-week randomized trial (NCT0192052) of 33 moderately asthmatic children (6-17 years). Patients were randomized aerobic training (exercise group; n = 14), while another group did not exercise (control; n = 19)...
October 2014: Respiratory Medicine
Qingwu Qin, Juntao Feng, Chengping Hu, Xi Chen, Ling Qin, Yuanyuan Li
Exercise is one of the most common triggers of bronchoconstriction in patients with asthma. The low levels of circulating epinephrine produced by the adrenal medullary chromaffin cells (AMCCs) are associated with exercise-induced bronchoconstriction (EIB) in asthmatics. In the present study, we tested the hypothesis that low-intensity aerobic exercise may ameliorate EIB using a rat model of asthma. Male Sprague-Dawley rats at 7 weeks of age, sensitized with ovalbumin or treated with saline, were subjected to low or moderate exercise training (50 or 75% of maximum velocity) for one hour in a treadmill 30 min after ovalbumin or saline inhalation...
2014: Tohoku Journal of Experimental Medicine
Qingwu Qin, Xi Chen, Juntao Feng, Ling Qin, Chengping Hu
BACKGROUND: Aerobic exercise can improve symptoms, reduce airway inflammation, and even ameliorate airway remodeling in asthmatic animals and patients. However, previous studies have focused mainly on the effect of aerobic exercise on steroid-sensitive asthma (SSA). The goals of this study were to determine the effect of low-intensity aerobic exercise training on airway hyperresponsiveness, inflammation, and remodeling in a rat model of steroid-resistant asthma (SRA) and to identify the potential mechanisms underlying these effects...
2014: Chinese Medical Journal
R A Silva, F M Almeida, C R Olivo, B M Saraiva-Romanholo, M A Martins, C R F Carvalho
The aim of this study was to investigate if the aerobic training (AT) reverses airway remodeling (AR) in an asthma model. BALB/c were divided into four groups: control (unsensitized and untrained); ovalbumin (OVA: sensitized and untrained); AT (unsensitized and trained) and OVA + AT. Allergic inflammation was induced with intraperitoneal and OVA inhalation. AT (low intensity; 5×/week; 60 min/session) was performed at 7, 15, and 30 days. Leukocyte counting in the bronchoalveolar lavage fluid; the expression of IL-5, eotaxin, RANTES, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1); AR features (airway smooth muscle, epithelium thickness, collagen and elastic fibers, mucus production); and AR inducers (transforming growing factor-beta, osteopontin, vascular endothelial growth factor)...
June 2015: Scandinavian Journal of Medicine & Science in Sports
Stefano R Del Giacco, Marco Scorcu, Federico Argiolas, Davide Firinu, G Sergio Del Giacco
BACKGROUND: In recent years, numerous articles have attempted to shed light on our understanding of the pathophysiological mechanisms of exercise-induced immunologic changes and their impact on allergy and asthma. It is known that lymphocyte subclasses, cytokines, and chemokines show modifications after exercise, but outcomes can be affected by the type of exercise as well as by its intensity and duration. Interesting data have been presented in many recent studies on mouse models, but few studies on humans have been performed to check the long-term effects of exercise over a whole championship season...
2014: BioMed Research International
Neil J Greening, Johanna E A Williams, Syed F Hussain, Theresa C Harvey-Dunstan, M John Bankart, Emma J Chaplin, Emma E Vincent, Rudo Chimera, Mike D Morgan, Sally J Singh, Michael C Steiner
OBJECTIVE: To investigate whether an early rehabilitation intervention initiated during acute admission for exacerbations of chronic respiratory disease reduces the risk of readmission over 12 months and ameliorates the negative effects of the episode on physical performance and health status. DESIGN: Prospective, randomised controlled trial. SETTING: An acute cardiorespiratory unit in a teaching hospital and an acute medical unit in an affiliated teaching district general hospital, United Kingdom...
2014: BMJ: British Medical Journal
Marcus S Smith
Despite worldwide popularity of amateur boxing, research focussed on the physiological demands of the sport is limited. The physiological profile of Senior and Junior England international amateur boxers is presented. A gradual (8 to 21-days) and rapid (0 to 7-days) phase of body weight reduction was evident with 2.2 ± 0.3 % of the 7.0 ± 0. 8 % weight loss occurring over the final 24-hours. An increase in body weight >4% was observed following a recovery period. High urine osmolality values (> 1000 mOsm·kg(-1)) were recorded during training and competition...
2006: Journal of Sports Science & Medicine
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