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https://www.readbyqxmd.com/read/27913556/how-does-age-related-macular-degeneration-affect-real-world-visual-ability-and-quality-of-life-a-systematic-review
#1
Deanna J Taylor, Angharad E Hobby, Alison M Binns, David P Crabb
OBJECTIVES: To review systematically the evidence of age-related macular degeneration (AMD) affecting real-world visual ability and quality of life (QoL). To explore trends in specific topics within this body of the literature. DESIGN: Systematic review. METHODS: A systematic literature search was carried out using MEDLINE, EMBASE, CINAHL, PsycINFO, PsychARTICLES and Health and Psychosocial Instruments for articles published up to January 2015 for studies including people diagnosed with AMD, assessing real-world visual ability or QoL as an outcome...
December 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27910824/accelerated-high-resolution-photoacoustic-tomography-via-compressed-sensing
#2
Simon Arridge, Paul Beard, Marta Betcke, Ben Cox, Nam Huynh, Felix Lucka, Olumide Ogunlade, Edward Zhang
Current 3D photoacoustic tomography (PAT) systems offer either high image quality or high frame rates but are not able to deliver high spatial and temporal resolution simultaneously, which limits their ability to image dynamic processes in living tissue (4D PAT). A particular example is the planar Fabry-Pérot (FP) photoacoustic scanner, which yields high-resolution 3D images but takes several minutes to sequentially map the incident photoacoustic field on the 2D sensor plane, point-by-point. However, as the spatio-temporal complexity of many absorbing tissue structures is rather low, the data recorded in such a conventional, regularly sampled fashion is often highly redundant...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27909486/misleading-advertising-by-attorneys-concerning-noacs-is-adversely-costly-to-our-patients-and-our-society
#3
EDITORIAL
James A, Reiffel M D
Over the past five years, "ambulance-chasing" attorneys have aggressively advertised for patients who have bled on a new oral anticoagulant (NOAC) or their family members. It is an infrequent day when American consumers do not see a TV advertisement saying something like: "Have you or a loved-one had a serious bleeding event while taking [fill in the NOAC]? If so, you may be entitled to monetary compensation. Call XXX, attorneys at law, and we will get you the money you deserve."
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908152/design-of-a-model-observer-to-evaluate-calcification-detectability-in-breast-tomosynthesis-and-application-to-smoothing-prior-optimization
#4
Koen Michielsen, Johan Nuyts, Lesley Cockmartin, Nicholas Marshall, Hilde Bosmans
PURPOSE: In this work, the authors design and validate a model observer that can detect groups of microcalcifications in a four-alternative forced choice experiment and use it to optimize a smoothing prior for detectability of microcalcifications. METHODS: A channelized Hotelling observer (CHO) with eight Laguerre-Gauss channels was designed to detect groups of five microcalcifications in a background of acrylic spheres by adding the CHO log-likelihood ratios calculated at the expected locations of the five calcifications...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27906965/do-elite-and-amateur-soccer-players-outperform-non-athletes-on-neurocognitive-functioning-a-study-among-8-12-year-old-children
#5
Lot Verburgh, Erik J A Scherder, Paul A M Van Lange, Jaap Oosterlaan
AIM: Research suggested a positive association between physical fitness and neurocognitive functioning in children. Aim of the present study is to investigate possible dose-response relationships between diverse daily physical activities and a broad range of neurocognitive functions in preadolescent children. Furthermore, the relationship between several sedentary behaviours, including TV-watching, gaming and computer time, and neurocognitive functioning will be investigated in this group of children...
2016: PloS One
https://www.readbyqxmd.com/read/27904047/protective-effect-of-deer-bone-oil-on-cartilage-destruction-in-rats-with-monosodium-iodoacetate-mia-induced-osteoarthritis
#6
Hyeon-Son Choi, Suji Im, Je Won Park, Hyung Joo Suh
The anti-osteoarthritic activity of the methanol fraction of deer bone oil extract (DBO-M) was evaluated in interleukin (IL)-1β-inflamed primary rabbit chondrocytes and in rats with monosodium iodoacetate (MIA)-induced osteoarthritis. The active compound in DBO-M was analyzed using a direct infusion liquid chromatography quadrupole (LCQ) ion-trap electrospray ionization (ESI)-mass spectrometer (MS). DBO-M significantly suppressed the IL-1β-induced sulfated-glycosaminoglycan (s-GAG) release from chondrocyte, and lowered mRNA levels of the collagen-degrading enzymes matrix metalloproteinase (MMP)-1 and MMP-3 in a dose-dependent manner...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27901182/does-insulin-resistance-increase-thyroid-volume-in-patients-with-polycystic-ovary-syndrome
#7
Murat Sahin, Didem Demircioglu, Ayten Oguz, Dilek Tuzun, Mehmet Akif Sarica, Elif Inanc, Kamile Gul
Objective: To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods: 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27900910/tv-soap-films-special-dementia-episode
#8
(no author information available yet)
Emmerdale, the ITV soap opera, will feature a storyline in which former vicar Ashley Thomas, played by John Middleton, is diagnosed with stroke-related early onset vascular dementia.
November 30, 2016: Nursing Older People
https://www.readbyqxmd.com/read/27900336/optimal-lateral-row-anchor-positioning-in-posterior-superior-transosseous-equivalent-rotator-cuff-repair-a-micro-computed-tomography-study
#9
Matthias A Zumstein, Sumit Raniga, Agatha Labrinidis, Kevin Eng, Gregory I Bain, Beat K Moor
BACKGROUND: The optimal placement of suture anchors in transosseous-equivalent (TOE) double-row rotator cuff repair remains controversial. PURPOSE: A 3-dimensional (3D) high-resolution micro-computed tomography (micro-CT) histomorphometric analysis of cadaveric proximal humeral greater tuberosities (GTs) was performed to guide optimal positioning of lateral row anchors in posterior-superior (infraspinatus and supraspinatus) TOE rotator cuff repair. STUDY DESIGN: Descriptive laboratory study...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27897306/-multiple-sclerosis-in-literature-cinema-and-television
#10
REVIEW
S Collado-Vazquez, J M Carrillo, R Cano-de-la-Cuerda
INTRODUCTION: Today, the care of patients with multiple sclerosis and those around them represents a clinical and therapeutic challenge for healthcare professionals. The aim of this study is to analyse the appearance of multiple sclerosis in literature, cinema and television, and to reflect upon the image it has in these media. DEVELOPMENT: Several representative works that have addressed multiple sclerosis were reviewed, and many of them were seen to offer a very true-to-life vision of the disease...
December 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27894612/influence-of-social-networks-on-congresses-of-urological-societies-and-associations-results-of-the-81th-national-congress-of-the-spanish-urological-association
#11
J Gómez-Rivas, M E Rodríguez-Socarrás, L Tortolero-Blanco, M Garcia-Sanz, M Alvarez-Maestro, M J Ribal, M Cózar-Olmo
OBJECTIVE: To measure social network activity during the 81th National Congress of the Spanish Urological Association (AEU) and to compare it with the activity during other congresses of national and international urological associations. MATERIAL AND METHODS: We designed and registered the official hashtag #AEU16 for the 81(th) National Congress of the AEU on the Symplur website. The following measurements were recorded: number of participants, number of tweets, tweets by participant, tweets per hour and views...
November 25, 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27891668/systematic-mapping-of-the-subchondral-bone-3d-microarchitecture-in-the-human-tibial-plateau-variations-with-joint-alignment
#12
Bryant C Roberts, Dominic Thewlis, Lucian B Solomon, Graham Mercer, Karen J Reynolds, Egon Perilli
Tibial subchondral bone plays an important role in knee osteoarthritis (OA). Microarchitectural characterization of subchondral bone plate (SBP), underlying subchondral trabecular bone (STB) and relationships between these compartments, however, is limited. The aim of this study was to characterize the spatial distribution of SBP thickness, SBP porosity and STB microarchitecture, and relationships among them, in OA tibiae of varying joint alignment. Twenty-five tibial plateaus from end-stage knee-OA patients, with varus (n = 17) or non-varus (n = 8) alignment were micro-CT scanned (17 μm/voxel)...
November 7, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27890798/performance-of-the-subcutaneous-implantable-defibrillator-in-primary-prevention-patients-with-and-without-reduced-ejection-fraction-versus-secondary-prevention-patients
#13
Lucas Boersma, Craig S Barr, Martin C Burke, Angel R Leon, Dominic A Theuns, John M Herre, Raul Weiss, Mark S Kremers, Petr Neuzil, Michael P Husby, Nathan Carter, Timothy M Stivland, Michael R Gold
BACKGROUND: The subcutaneous implantable defibrillator (S-ICD) provides an alternative to the transvenous ICD (TV-ICD) for prevention of sudden cardiac death (SCD), but has not been well studied in the most commonly treated TV-ICD patient population, namely primary prevention (PP) patients with left ventricular (LV) dysfunction. OBJECTIVE: These analyses were designed to compare clinical outcomes for PP patients with and without a reduced ejection fraction (EF) and secondary prevention (SP) patients implanted with the S-ICD...
November 24, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27883078/impaired-endothelial-nitric-oxide-synthase-homodimer-formation-triggers-development-of-transplant-vasculopathy-insights-from-a-murine-aortic-transplantation-model
#14
Rupert Oberhuber, Gregor Riede, Benno Cardini, David Bernhard, Barbara Messner, Katrin Watschinger, Christina Steger, Gerald Brandacher, Johann Pratschke, Georg Golderer, Ernst R Werner, Manuel Maglione
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown to prevent IRI. Herein, we analysed whether tetrahydrobiopterin is also involved in TV development. Using a fully allogeneic mismatched (BALB/c to C57BL/6) murine aortic transplantation model grafts subjected to long cold ischemia time developed severe TV with intimal hyperplasia (α-smooth muscle actin positive cells in the neointima) and endothelial activation (increased P-selectin expression)...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27881116/concurrent-agreement-between-an-anthropometric-model-to-predict-thigh-volume-and-dual-energy-x-ray-absorptiometry-assessment-in-female-volleyball-players-aged-14-18-years
#15
Óscar M Tavares, João Valente-Dos-Santos, João P Duarte, Susana C Póvoas, Luís A Gobbo, Rômulo A Fernandes, Daniel A Marinho, José M Casanova, Lauren B Sherar, Daniel Courteix, Manuel J Coelho-E-Silva
BACKGROUND: A variety of performance outputs are strongly determined by lower limbs volume and composition in children and adolescents. The current study aimed to examine the validity of thigh volume (TV) estimated by anthropometry in late adolescent female volleyball players. Dual-energy X-ray absorptiometry (DXA) measures were used as the reference method. METHODS: Total and regional body composition was assessed with a Lunar DPX NT/Pro/MD+/Duo/Bravo scanner in a cross-sectional sample of 42 Portuguese female volleyball players aged 14-18 years (165...
November 24, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27878399/altered-architecture-and-cell-populations-affect-bone-marrow-mechanobiology-in-the-osteoporotic-human-femur
#16
Thomas A Metzger, Ted J Vaughan, Laoise M McNamara, Glen L Niebur
Age-related increases in trabecular bone porosity, as seen in osteoporosis, not only affect the strength and stiffness, but also potentially the mechanobiological response of bone. The mechanical interaction between trabecular bone and bone marrow is one source of mechanobiological signaling, as many cell populations in marrow are mechanosensitive. However, measuring the mechanics of this interaction is difficult, due to the length scales and geometric complexity of trabecular bone. In this study, a multi-scale computational scheme incorporating high-resolution, tissue-level, fluid-structure interaction simulations with discrete cell-level models was applied to characterize the potential effects of trabecular porosity and marrow composition on marrow mechanobiology in human femoral bone...
November 22, 2016: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/27878381/posttraumatic-stress-and-quality-of-life-with-the-totally-subcutaneous-compared-to-conventional-cardioverter-defibrillator-systems
#17
Julia Köbe, Katharina Hucklenbroich, Nils Geisendörfer, Markus Bettin, Gerrit Frommeyer, Florian Reinke, Dirk Dechering, Markus Burgmer, Lars Eckardt
BACKGROUND: For prevention of sudden cardiac death, the transvenously implantable cardioverter-defibrillator therapy (tv-ICD) is well accepted. The subcutaneous system (S-ICD(®)) is promising in terms of reducing ICD complications. Nevertheless, the impact of the novel generator position on patients' quality of life (QoL) is yet unknown. OBJECTIVE: This study aimed at comparing QoL and posttraumatic stress with both systems. METHODS: 60 S-ICD(®) and 60 case-controlled tv single-chamber ICD patients were asked to respond to three standardized questionnaires...
November 22, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27875224/parallel-proximal-algorithm-for-anisotropic-total-variation-minimization
#18
Ulugbek Kamilov
Total variation (TV) is a one of the most popular regularizers for stabilizing the solution of ill-posed inverse problems. This paper proposes a novel proximal-gradient algorithm for minimizing TV regularized least-squares cost functionals. Unlike traditional methods that require nested iterations for computing the proximal step of TV, our algorithm approximates the latter with several simple proximals that have closed form solutions. We theoretically prove that the proposed parallel proximal method achieves the TV solution with arbitrarily high precision at a global rate of converge that is equivalent to the fast proximalgradient methods...
November 16, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/27875059/cortical-bone-area-predicts-incident-fractures-independently-of-areal-bone-mineral-density-in-older-men
#19
Claes Ohlsson, Daniel Sundh, Andreas Wallerek, Martin Nilsson, Magnus Karlsson, Helena Johansson, Dan Mellström, Mattias Lorentzon
CONTEXT: Areal bone mineral density (aBMD) measured using dual-energy X-ray absorptiometry (DXA) is used clinically to predict fracture but does not allow discrimination between the trabecular and cortical bone compartments or assessment of cortical porosity. OBJECTIVE: To investigate if distinct information on cortical and trabecular bone parameters predict fracture risk independently of aBMD and clinical risk factors. DESIGN & PARTICIPANTS: Cortical area, cortical bone mass, trabecular bone volume fraction, and cortical porosity were measured at the tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in 456 men (80...
November 22, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27875021/lifestyle-and-bowel-movements-in-school-children-results-from-the-toyama-birth-cohort-study
#20
Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse
BACKGROUND: Constipation is prevalent health disorder and it has been bothering many pediatricians as well as people suffering from constipation. There have been few epidemiological surveys about constipation in Japanese children. This study aims to evaluate the prevalence of non-daily bowel movements (BM) and irregular BM among children and to identify modifiable lifestyle factors relevant to their bowel habits. METHODS: Subjects were from the Toyama Birth Cohort Study in Japan...
November 22, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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