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Toby Raeburn, Carol Liston, Jarrad Hickmott, Michelle Cleary
Despite making a substantial contribution to the development of mental health services in colonial Australia, until now the story of Dr Patrick Hill's (1794-1852) life has been overlooked by historians. This paper reviews primary sources including clinical notes, patient lists, letters, government documents and newspaper articles which reveal that Dr Hill was a dedicated physician who played a vital role in the development of Australian mental healthcare. He was held in such esteem that by the time of his sudden death in 1852 he had been elevated to the most senior medical office in New South Wales...
November 12, 2018: History of Psychiatry
Mark Hamer, Gary O'Donovan, Emmanuel Stamatakis
Physical activity is thought to be cardioprotective, but associations with different subtypes of cardiovascular disease (CVD) are poorly understood. We examined associations between physical activity and seven major CVD death causes. The sample comprised 65,093 adults (aged 58 ± 12 years, 45.4% men) followed up over mean [SD] 9.4 ± 4.5 years, recruited from The Health Survey for England and the Scottish Health Surveys. A CVD diagnosis was reported in 9.2% of the sample at baseline. Physical activity was self-reported...
November 11, 2018: European Journal of Epidemiology
Serge Sicouri, Charles Antzelevitch
A number of antipsychotic and antidepressant drugs are known to increase the risk of ventricular arrhythmias and sudden cardiac death. Based largely on a concern over the development of life-threatening arrhythmias, a number of antipsychotic drugs have been temporarily or permanently withdrawn from the market or their use restricted. While many antidepressants and antipsychotics have been linked to QT prolongation and the development of torsade de pointes arrhythmias, some have been associated with a Brugada syndrome phenotype and the development of polymorphic ventricular arrhythmias...
August 2018: Arrhythmia & Electrophysiology Review
Frédéric Schnell, Nathalie Behar, François Carré
Long QT syndrome (LQTS) is an inherited channelopathy which exposes athletes to a risk of sudden cardiac death. Diagnosis is more difficult in this population because: the QT interval is prolonged by training; and the extreme bradycardia frequently observed in athletes makes the QT correction formula less accurate. Based on limited clinical data which tend to demonstrate that exercise, especially swimming, is a trigger for cardiac events, participation in any competitive sports practice is not supported by 2005 European guidelines...
August 2018: Arrhythmia & Electrophysiology Review
Aneil Malhotra, Sanjay Sharma
Sudden cardiac death (SCD) in a young person is a rare but tragic occurrence. The impact is widespread, particularly in the modern era of media coverage and visibility of social media. Hypertrophic cardiomyopathy (HCM) is reported historically as the most common cause of SCD in athletes younger than 35 years of age. A diagnosis of HCM may be challenging in athletes as pathological hypertrophy of the left ventricle may also mimic physiological left ventricular hypertrophy (LVH) in response to exercise. Differentiation of physiological LVH from HCM requires an array of clinical tools that rely on detecting subtle features of disease in a supposedly healthy person who represents the segment of society with the highest functional capacity...
December 2017: European Cardiology
Anisha Ramniklal Gala, Tarakeswari Surapaneni, Nuzhat Aziz, Sailaja Devi Kallur
Background: The course of pregnancy in a woman with portal hypertension is a difficult one as it is associated with complications like variceal bleeding, splenic artery rupture and coagulopathy. All these pose a threat to a woman's life. Although this condition is rare, every obstetrician should have a high index of suspicion when an antenatal mother presents with splenomegaly, thrombocytopenia or hematemesis. Hence, we aimed to review maternal and fetal outcomes in pregnant women with portal hypertension...
December 2018: Journal of Obstetrics and Gynaecology of India
Piero Gentile, Alessia Paldino, Antonio Cannatà, Jessica Artico, Giulia Barbati, Federica Ramani, Enrico Fabris, Aneta Aleksova, Davide Stolfo, Massimo Zecchin, Marco Merlo, Gianfranco Sinagra
BACKGROUND: Left bundle branch block (LBBB) negatively affects prognosis in heart failure patients with a reduced left ventricular ejection fraction (LVEF). Less is known about the prognostic role of LBBB in dilated cardiomyopathy (DCM) with intermediate LVEF (between 36% and 50%). We sought to assess the role of LBBB in optimally treated DCM patients with mildly to moderately reduced LVEF and to determine the possible variables associated with subsequent LVEF reduction. METHODS: We retrospectively analyzed DCM patients with LVEF >35% after 3-to-9 months of optimal medical treatment (OMT) consecutively evaluated from 1990 to 2010...
November 5, 2018: International Journal of Cardiology
Douglas Robinson, Gregory Hand, Jason Ausman, Anthony Hackett
BACKGROUND: Brugada pattern is a well-known pathological finding on electrocardiogram (ECG) which increases the likelihood of cardiac arrest due to ventricular arrhythmia. These cases generally present in younger patients without evidence of an electrolyte abnormality, structural heart disease, or cardiac ischemia. In many instances, this pattern is either hidden on initial presentation or presents as an incidental finding on an EKG. Often times the Brugada syndrome leads to sudden cardiac death or more rarely can be unmasked with a class 1A or 1C anti-arrhythmic agent...
October 23, 2018: American Journal of Emergency Medicine
Kazuma Sugie, Hirofumi Komaki, Nobuyuki Eura, Tomo Shiota, Kenji Onoue, Hiroyasu Tsukaguchi, Narihiro Minami, Megumu Ogawa, Takao Kiriyama, Hiroshi Kataoka, Yoshihiko Saito, Ikuya Nonaka, Ichizo Nishino
Danon disease, an X-linked dominant cardioskeletal myopathy, is caused by primary deficiency of lysosome-associated membrane protein-2 (LAMP-2). To clarify the clinicopathological features and management, we performed the first nationwide, questionnaire-based survey on Danon disease in Japan. A total of 39 patients (17 males, 22 females) from 20 families were identified in the analysis. All patients had cardiomyopathy. Of the 21 patients who died, 20 (95%) died of cardiac failure or sudden cardiac arrest. Most patients had hypertrophic cardiomyopathy...
November 8, 2018: International Journal of Molecular Sciences
Hao Cui, Jizheng Wang, Ce Zhang, Guixin Wu, Changsheng Zhu, Bing Tang, Yubao Zou, Xiaohong Huang, Rutai Hui, Lei Song, Shuiyun Wang
BACKGROUND: Filamin C (FLNC) mutation was reported as a cause of HCM, with a high probability of sudden cardiac death. However, the mutation profile of FLNC, and its relationship with phenotypic expression in HCM, remains to be elucidated. METHODS: In this study, FLNC gene was sequenced in 540 HCM patients and 307 healthy controls. RESULTS: We found that 39 (7.2%) patients carried FLNC mutations, with a similar frequency to that of controls (4...
November 8, 2018: Molecular Genetics & Genomic Medicine
Syed Rizwan A Bokhari, Faisal Inayat, Ali Jawa, Hafeez Ul Hasan Virk, Muhammad Awais, Nadeem Hussain, Ghias Ul Hassan, Hafiz Ijaz Ahmad, Hammad S Chaudhry, Abdullah Adil, Ali Haider, Vincent M Figueredo, Janani Rangaswami, Muhammad Zaman Khan Assir
Background End-stage renal disease frequently leads to increased cardiovascular mortality. Cardiovascular autonomic neuropathy (CAN) may be predictive of cardiac arrhythmias and sudden cardiac death in patients with end-stage renal disease. Methods A total of 70 patients with end-stage renal disease were included in the study. The assessment of cardiac dysautonomia was based on the four standardized tests performed at the baseline and, again, at the end of the study. The criteria for CAN included at least two abnormal test results...
August 31, 2018: Curēus
Erik Hohmann, Vaida Glatt, Kevin Tetsworth
Background: Swimming induced pulmonary oedema is an uncommon occurrence and usually presents during strenuous distance swimming in cold water. The prevalence is most likely underreported and the underlying mechanisms are controversial. The purpose of this study was to summarize the evidence with regards to prevalence, pathophysiology and treatment of swimming induced pulmonary oedema in endurance athletes. Methods: Medline, Embase, Scopus and Google Scholar were searched and level I-IV from 1970 to 2017 were included...
2018: BMC Sports Science, Medicine and Rehabilitation
Emily Farrell, Annie E Armstrong, Adrian C Grimes, Francisco J Naya, Willem J de Lange, J Carter Ralphe
Rationale: With a prevalence of 1 in 200 individuals, hypertrophic cardiomyopathy (HCM) is thought to be the most common genetic cardiac disease, with potential outcomes that include severe hypertrophy, heart failure, and sudden cardiac death (SCD). Though much research has furthered our understanding of how HCM-causing mutations in genes such as cardiac myosin-binding protein C ( MYBPC3 ) impair contractile function, it remains unclear how such dysfunction leads to hypertrophy and/or arrhythmias, which comprise the HCM phenotype...
2018: Frontiers in Physiology
Emrah Ermis, Serkan Kahraman, Hakan Ucar, Sinem Ozbay Ozyılmaz, Samir Allahverdiyev
Simultaneous multivessel epicardial coronary artery thrombosis is an uncommon finding in acute ST-segment elevation myocardial infarction (STEMI). It generally leads to cardiogenic shock and sudden cardiac death in the hospital. We report a 42-year-old male patient presenting with acute anterior STEMI with triple coronary artery thrombosis. An emergency coronary angiogram showed total occlusion of the left anterior descending artery (LAD) with thrombus formation. At the same time, thrombus formations were also seen in the circumflex artery (CXA), the second obtuse marginal (OM2) branch, and the distal right coronary artery (RCA)...
December 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Maksim Kashtanov, Anastasiya Rzhannikova, Sergey Chernyshev, Lev Kardapoltsev, Eduard Idov, Sergey Berdnikov
This study looks at 10-year follow-up outcomes of alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy. Between 2000 and 2008, 40 patients with obstructive hypertrophic cardiomyopathy (27 males, 13 females) underwent alcohol septal ablation. The median follow-up period was 123 (2-179) months. The mean age ran to 43.8 + 13.9 years. The initial dose of ethanol (3 mL) was chosen for ablation in all cases. The hospital mortality was 0%. Permanent pacemakers were implanted in 3 of 40 (7...
December 2018: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Alexandros Protonotarios, Eleanor Wicks, Michael Ashworth, Edward Stephenson, Oliver Guttmann, Kostas Savvatis, Neha Sekhri, Saidi A Mohiddin, Petros Syrris, Leon Menezes, Perry Elliott
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable heart muscle disease that causes sudden cardiac death in the young. Inflammatory myocardial infiltrates have been described at autopsy and on biopsy, but there are few data on the presence of myocarditis in living patients with ARVC using non-invasive imaging techniques. FDG-PET is a validated technique for detecting myocardial inflammation in clinically suspected myocarditis. We aimed to determine the prevalence of myocardial inflammation in patients with ARVC using 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET)...
October 26, 2018: International Journal of Cardiology
Richard D Goldstein, Carter R Petty, Sue E Morris, Melanie Human, Hein Odendaal, Amy Elliott, Deb Tobacco, Jyoti Angal, Lucy Brink, Hannah C Kinney, Holly G Prigerson
BACKGROUND: Identifying characteristics of individuals at greatest risk for prolonged grief disorder (PGD) can improve its detection and elucidate the etiology of the disorder. The Safe Passage Study, a study of women at high risk for sudden infant death syndrome (SIDS), prospectively examined the psychosocial functioning of women while monitoring their healthy pregnancies. Mothers whose infants died of SIDS were followed in bereavement. METHODS: Pre-loss data were collected from 12 000 pregnant mothers and analyzed for their associations with grief symptoms and PGD in 50 mothers whose infants died from SIDS, from 2 to 48 months after their infant's death, focusing on pre-loss risk factors of anxiety, depression, alcohol use, maternal age, the presence of other living children in the home, and previous child loss...
November 9, 2018: Psychological Medicine
Merrill H Stewart, Carl J Lavie, Sangeeta Shah, Joseph Englert, Yvonne Gilliland, Salima Qamruddin, Homeyar Dinshaw, Michael Cash, Hector Ventura, Richard Milani
Left ventricular hypertrophy (LVH) was one of the earliest studied echocardiographic characteristics of the left ventricle. As the myriad of measurable metrics has multiplied over recent years, this reliable and relevant variable can often be overlooked. In this paper, we discuss appropriate techniques for accurate analysis, underlying pathophysiology, and the contributions from various risk factors. The prognostic implications of LVH on stroke, serious arrhythmias, and sudden cardiac death are reviewed. Finally, we examine the effect of therapy to reduce LVH and the resultant clinical outcomes...
November 5, 2018: Progress in Cardiovascular Diseases
Alba González, Dag Aurlien, Kristina H Haugaa, Erik Taubøll
The congenital long QT syndrome (cLQTS) is an inherited cardiac disorder and is associated with sudden cardiac death. We describe a Norwegian family with mutations within the KCNQ1 gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS...
2018: Epilepsy & Behavior Case Reports
Robert Hughes, Johnathan M Sheele
We report the case of a person who went into cardiac arrest after being given chlorpromazine for hiccups and was subsequently diagnosed with congenital Long QT Syndrome. Long QT Syndrome is an uncommon, congenital condition that carries a high risk of sudden cardiac death. Clinicians need to recognize the risk that chlorpromazine may prolong the QTc and prepare to manage potential complications.
2018: Case Reports in Emergency Medicine
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