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Death sudden

Xiaoli Liu, Jianli Shi, Peilin Xiao
BACKGROUND: We sought to identify common ion channel single nucleotide polymorphisms (SNPs) associated with the occurrence of sudden cardiac death (SCD) to predict the incidence of SCD in clinical settings. METHODS: This study involved a systematic review and meta-analysis of ion channel SNPs and risk of SCD in adults. We searched public databases for studies published up to September 19, 2017. We examined relationships between SNPs in common ion channel genes and the incidence of SCD...
September 2018: Medicine (Baltimore)
Matthias Bopp, Yolanda W H Penders, Samia A Hurst, Georg Bosshard, Milo A Puhan
BACKGROUND: Medical end-of-life decisions (MELD) and shared decision-making are increasingly important issues for a majority of persons at the end of life. Little is known, however, about the impact of physician characteristics on these practices. We aimed at investigating whether MELDs depend on physician characteristics when controlling for patient characteristics and place of death. METHODS AND FINDINGS: Using a random sample (N = 8,963) of all deaths aged 1 year or older registered in Switzerland between 7 August 2013 and 5 February 2014, questionnaires covering MELD details and physicians' demographics, life stance and medical formation were sent to certifying physicians...
2018: PloS One
Jonathan Ilicki, Samuel Bruchfeld, Therese Djärv
Approximately 10% of sudden cardiac deaths among patients under 35 years of age is owing to hypertrophic cardiomyopathy (HCM)-related cardiac arrest (CA). CA is often associated with pre-arrest or peri-arrest hypotension and is treated by a set of interventions, including the administration of epinephrine. It is debated whether epinephrine increases or decreases survival to discharge following CA. HCM is associated with septal hypertrophy with a dynamic left ventricular outflow tract obstruction and impaired peripheral vasoconstriction in response to α1-adrenergic stimulation, both of which could cause epinephrine to have a different effect than in the general population...
September 18, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
Francesco Lupariello, Serena Maria Curti, Giancarlo Di Vella
The diagnosis of lethal commotio cordis (CC) is really complex. The forensic pathologist's task is even more relevant when he/she has to explain a CC diagnosis caused by an assault in a trial. The purpose of this study was to analyze the literature on lethal CC as a result of violent attacks and identify relevant parameters that may help in the diagnosis. A review of the relevant articles was performed. Fifty-two cases of CC caused by violent attacks were identified. The collected data allowed to confirm the following literature's criteria for CC diagnosis in case of assaults: witnessed occurrence of a blunt, nonpenetrating blow to the chest preceding cardiovascular collapse; absence of structural damage to the sternum, ribs, or heart itself; and absence of any underlying cardiovascular abnormalities (such as other causes of sudden death)...
September 17, 2018: American Journal of Forensic Medicine and Pathology
Benjamin Oosterhoff, Julie B Kaplow, Christopher M Layne
Bereavement due to sudden loss may disrupt positive adjustment among youth, yet few studies have examined the age at which youth are most likely to first encounter sudden loss, the co-occurrence of sudden loss with other traumatic events, and the independent effects of sudden loss on academic functioning. Data were analyzed from the National Comorbidity Survey-Adolescent Supplement (N = 10,148, Mage = 15.18, 51.1% female). Youth reported on whether they had experienced sudden loss (along with 17 other traumatic events), the age at which they had first experienced sudden loss, and multiple indicators of academic functioning...
September 2018: School Psychology Quarterly
Anna Natalia Last, Jennifer English, Helen Pote, Roz Shafran, Tamsin Owen, Juan Pablo Kaski
Objectives: Inherited cardiac arrhythmia syndromes are life-threatening conditions. There is a paucity of research examining the psychological impact of these conditions in children. This study had three main aims. The first was to explore how the Cardiac Anxiety Questionnaire (CAQ) performs in a child population. The second aim was to compare the level of anxiety of children with an inherited cardiac arrhythmia syndrome and children being screened due to a family history of an inherited cardiac arrhythmia syndrome to control children...
2018: BMJ Paediatrics Open
Chimango V T Munthali, Sophie Kang'oma, Khazgani Nasasara, Lindiwe M Zaina, Chawanangwa Lupafya, Jacob Mziya, Anthony D Harries, Kudakwashe C Takarinda, Martha Kwataine, Isaac Dambula, Simeon Yosefe
Introduction: Most people in Africa die without appearing in official vital statistics records. To improve this situation, Malawi has introduced solar-powered electronic village registers (EVR), managed by village headmen, to record birth and death information for production of vital statistics. The EVR is deployed in 83 villages in Traditional Authority Mtema, Lilongwe, which is an area without electricity. In 17 villages, village headmen were also trained to use a simple verbal autopsy (VA) tool adapted from one developed by the World Health Organization (WHO)...
2018: Frontiers in Public Health
Christian Schlatzer, Daniel J Bratton, Esther I Schwarz, Thomas Gaisl, Justin C T Pepperell, John R Stradling, Malcolm Kohler
Background: Obstructive sleep apnoea (OSA) has been proposed as an independent risk factor for sudden cardiac death (SCD). This study takes advantage of a previous randomized trial and seeks to evaluate circadian patterns of the QTc-interval, a marker of cardiac repolarization and biomarker for SCD, in patients with OSA. We hypothesized that patients with OSA would exhibit longest QTc during the night-time and that continuous positive airway pressure (CPAP) therapy would reverse this...
August 2018: Journal of Thoracic Disease
Gary Tse, Mengqi Gong, Lei Meng, Cheuk W Wong, George Bazoukis, Matthew T V Chan, Martin C S Wong, Konstantinos P Letsas, Adrian Baranchuk, Gan-Xin Yan, Tong Liu, William K K Wu
Background: Acquired QT interval prolongation has been linked with malignant ventricular arrhythmias, such as torsade de pointes , in turn predisposing to sudden cardiac death. Increased dispersion of repolarization has been identified as a pro-arrhythmic factor and can be observed as longer Tpeak - Tend interval and higher Tpeak - Tend /QT ratio on the electrocardiogram. However, the values of these repolarization indices for predicting adverse outcomes in this context have not been systematically evaluated...
2018: Frontiers in Physiology
Wael Majdoub, Amal Mosbahi, Frederic Bonbled
Fournier gangrene is a rare fulminant necrotizing infection of the skin and soft tissue of the perineum that may result in rapid death. We describe the autopsy case of a 70-year-old female with uncontrolled diabetes mellitus who was found unexpectedly dead in her house where she lived with her dog. Examination of the body revelaed a deep necrotic ulceration of the perineum with exposure of the underlying deep muscles that was initially misinterpreted by police officers as post mortem animal predation. Medicolegal examination and histological and microbiological analyses eliminated this hypothesis and the diagnosis of septic multiorgan failure due to necrotizing fasciitis was retained as a cause of death...
September 19, 2018: Forensic Science, Medicine, and Pathology
Andrew H Schapiro, Mantosh S Rattan, Ryan A Moore, Jonathan R Dillman
History A 17-year-old white male adolescent was re-evaluated for a withheld cardiac condition initially detected during prenatal imaging at an outside institution. He had previously experienced intermittent episodes of shortness of breath, chest pain, and palpitations with exertion, but more recently he had been asymptomatic. He had no other comorbidities and no family history of congenital heart disease, cardiomyopathy, arrhythmia, or sudden cardiac death. At physical examination, the patient had a grade II/IV rumbling systolic murmur best heard at the left upper sternal border...
October 2018: Radiology
Katsuhide Hayashi, Ritsuko Kohno, Naoki Akamatsu, David G Benditt, Haruhiko Abe
BACKGROUND: Recently, certain forms of early repolarization (ER) on electrocardiograms (ECGs) have been considered a possible marker of increased sudden cardiac death risk. The frequency, characteristics, and clinical follow-up with which these forms of ER are present in epilepsy patients and whether abnormal ER contributes to Sudden Unexplained Death in Epilepsy Patients (SUDEP) is unknown. METHODS AND RESULTS: The amplitude of J peak and ST segment morphology after ER on 12-lead ECGs were assessed in 354 epilepsy patients (age, 33 ± 16 years; 54% men) and 140 age- and sex-matched control subjects (age, 31 ± 12 years; 50% men)...
September 19, 2018: Journal of Cardiovascular Electrophysiology
Tomokazu Kawashima, Fumi Sato
This article presents data on the anatomical variation of the origin, course and distribution of the artery to the atrioventricular node in humans. The findings hold clinical significance for coronary intervention, coronary angiography and cardiac pathology in cases of sudden cardiac death. For further interpretation and discussion, the original research article 'Clarifying the anatomy of the atrioventricular node artery' by Kawashima and Sato (2018) can be referred [1].
October 2018: Data in Brief
Gavin McClean, Nathan R Riding, Guido Pieles, Victoria Watt, Carmen Adamuz, Sanjay Sharma, Keith P George, David Oxborough, Mathew G Wilson
OBJECTIVE: Historically, electrocardiographic (ECG) interpretation criteria for athletes were only applicable to adults. New international recommendations now account for athletes ≤16 years, but their clinical appropriateness is unknown. We sought to establish the diagnostic accuracy of new international ECG recommendations against the Seattle criteria and 2010 European Society of Cardiology (ESC) recommendations in paediatric athletes using receiver operator curve analysis. Clinical context was calculated using Bayesian analysis...
September 18, 2018: Heart: Official Journal of the British Cardiac Society
Scott J Cameron, Hannah Russell, A Phillip Owens
Abdominal aortic aneurysm (AAA) is a degenerative vascular pathology resulting in significant morbidity and mortality in older adults due to rupture and sudden death. Despite 150,000 new cases and nearly 15,000 deaths annually, the only approved treatment for AAA is surgical or endovascular intervention when the risk for aortic rupture is increased. The goal of the scientific community is to develop novel pharmaceutical treatment strategies to reduce the need for surgical intervention. As most clinically-relevant AAAs contain a complex structure of fibrin, inflammatory cells, platelets, and red blood cells in the aneurysmal sac known as an intraluminal thrombus (ILT), antithrombotic therapies have emerged as potential pharmaceutical agents for the treatment of AAA progression...
September 18, 2018: Blood
Victoria Scott-Warren, Anju Bendon, Iain A Bruce, Lise Henderson, Jacques Diacono
Congenital long QT syndrome (cLQTS) is an inherited cardiac ion channelopathy characterized by a long corrected-QT interval on the ECG, associated with a risk of syncope and sudden death as a result of arrhythmias. The archetypal arrhythmia associated with cLQTS is torsade de pointes which may degenerate into ventricular fibrillation. Children with Jervell and Lange-Neilsen syndrome have the combination of cLQTS and congenital sensorineural deafness and may present for cochlear implantation (CI). Sympathetic stimulation and administration of QT-prolonging medications may trigger arrhythmias in children with cLQTS and thus the perioperative period is a time of increased risk of adverse events, with deaths reported in the CI literature...
November 2018: Cochlear Implants International
Jesper M Rantanen, Sam Riahi, Martin B Johansen, Erik B Schmidt, Jeppe H Christensen
Marine n -3 polyunsaturated fatty acids (PUFA) may improve autonomic dysfunction, as indicated by an increase in heart rate variability (HRV) and reduce the risk of sudden cardiac death. Hence, the aim of this study was to investigate the effects of marine n -3 PUFA on 24-h HRV in patients on chronic dialysis, who have a high risk of sudden cardiac death. Between June 2014 and March 2016, 112 patients on chronic dialysis from Denmark were allocated to a daily supplement of 2 g marine n -3 PUFA or control for three months in a randomized, double-blinded, controlled trial...
September 17, 2018: Nutrients
Edmundo Arteaga-Fernández, Murillo de Oliveira Antunes
No abstract text is available yet for this article.
June 2018: Arquivos Brasileiros de Cardiologia
Liliana Reis, Rogerio Teixeira, Andreia Fernandes, Inês Almeida, Marta Madeira, Joana Silva, Ana Botelho, João Pais, José Nascimento, Lino Gonçalves
BACKGROUND: The new European Society of Cardiology guidelines for hypertrophic cardiomyopathy (HCM) define the estimation of sudden cardiac death (SCD) risk as an integral part of clinical management. An implantable cardioverter defibrillator (ICD) is recommended (class IIa) when the risk is ≥ 6%. OBJECTIVES: To compare the SCD risk stratification according to the 2011 and 2014 recommendations for ICD implantation in patients with HCM. METHODS: Retrospective study including 105 patients diagnosed with HCM...
June 2018: Arquivos Brasileiros de Cardiologia
E Samuli Lepojärvi, Heikki V Huikuri, Olli-Pekka Piira, Antti M Kiviniemi, Johanna A Miettinen, Tuomas Kenttä, Olavi Ukkola, Juha S Perkiömäki, Mikko P Tulppo, M Juhani Junttila
AIMS: Biomarkers have shown promising results in risk assessment of cardiovascular events. Their role in predicting the risk of sudden cardiac death (SCD) is not well established. We tested the performance of several biomarkers in risk assessment for SCD in patients with coronary artery disease (CAD) and preserved left ventricular function. METHODS AND RESULTS: The study population consisted of 1,946 CAD patients (68% male; mean age 66.9±8.6 yrs; type 2 diabetes (T2D) 43%) enrolled in the ARTEMIS study...
2018: PloS One
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