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https://www.readbyqxmd.com/read/30005558/endothelial-dysfunction-increased-arterial-stiffness-and-cardiovascular-risk-prediction-in-patients-with-coronary-artery-disease-fmd-j-flow-mediated-dilation-japan-study-a
#1
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
BACKGROUND: The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. METHODS AND RESULTS: We measured flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV) in 462 patients with coronary artery disease for assessment of the predictive value of FMD and baPWV for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death...
July 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30003108/elastic-tubing-resistance-training-and-autonomic-modulation-in-subjects-with-chronic-obstructive-pulmonary-disease
#2
Ana Laura Ricci-Vitor, Luiz Carlos M Vanderlei, Carlos Marcelo Pastre, Dionei Ramos, Ercy Mara C Ramos, Celso Ferreira Filho, Celso Ferreira
This study addresses evidence concerning elastic tubing resistance training (ET) on autonomic modulation in patients with chronic obstructive pulmonary disease (COPD). Autonomic dysfunction is common in COPD and contributes to the development of arrhythmias and sudden death. Along with autonomic dysfunction, muscle dysfunction is related to functional limitations and prognosis of the disease. This study investigated the effects of ET on autonomic modulation, muscle strength, and walking distance in COPD. Subjects were divided into two groups, ET ( n = 20; 66,5 ± 8,9 y; 25,5 ± 3,5 kg/m2 ; FEV1 /FVC: 50,3 ± 11,0) and conventional training ( n = 19; 66,0 ± 6,9; 27,1 ± 4,3; FEV1 /FVC: 55,05 ± 9,56)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/30002064/localized-structural-alterations-underlying-a-subset-of-unexplained-sudden-cardiac-death
#3
Michel Haïssaguerre, Mélèze Hocini, Ghassen Cheniti, Josselin Duchateau, Frédéric Sacher, Stéphane Puyo, Hubert Cochet, Masateru Takigawa, Arnaud Denis, Ruairidh Martin, Nicolas Derval, Pierre Bordachar, Philippe Ritter, Sylvain Ploux, Thomas Pambrun, Nicolas Klotz, Gregoire Massoullié, Xavier Pillois, Corentin Dallet, Jean-Jacques Schott, Solena Scouarnec, Michael J Ackerman, David Tester, Olivier Piot, Jean-Luc Pasquié, Christophe Leclerc, Jean-Sylvain Hermida, Estelle Gandjbakhch, Philippe Maury, Louis Labrousse, Ruben Coronel, Pierre Jais, David Benoist, Edward Vigmond, Mark Potse, Richard Walton, Koonlawee Nademanee, Olivier Bernus, Remi Dubois
BACKGROUND: Sudden cardiac death because of ventricular fibrillation (VF) is commonly unexplained in younger victims. Detailed electrophysiological mapping in such patients has not been reported. METHODS: We evaluated 24 patients (29±13 years) who survived idiopathic VF. First, we used multielectrode body surface recordings to identify the drivers maintaining VF. Then, we analyzed electrograms in the driver regions using endocardial and epicardial catheter mapping during sinus rhythm...
July 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/30001947/clarifying-the-anatomy-of-the-atrioventricular-node-artery
#4
Tomokazu Kawashima, Fumi Sato
BACKGROUND: Reports of conduction abnormalities necessitating permanent pacemaker implantation due to atrioventricular node artery injury and increasing evidence of stenosis of the atrioventricular node artery in cases of sudden death are of unsolved clinical importance. Unfortunately, technical issues associated with physical and virtual dissections of the atrioventricular conduction axis make it difficult to accurately assess its arterial supply. METHODS: We used a specialized dissection technique to gather anatomical information on the atrioventricular node artery and described them using attitudinally appropriate terminology...
July 5, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30001909/to-reveal-or-conceal-adult-patient-perspectives-on-sudep-disclosure
#5
Lucretia Long, Sheri Cotterman-Hart, Jennae Shelby
OBJECTIVE: The study aimed to evaluate adult patient or caregiver feelings and viewpoints about sudden unexpected death in epilepsy (SUDEP) awareness. BACKGROUND: The decision to discuss SUDEP with patients and families has created much debate. Many healthcare providers (HCPs) are hesitant to discuss SUDEP because of the perception of evoking unnecessary fear in patients while others argue that informing patients about SUDEP may enhance patient compliance, improve seizure control, and aid in saving lives...
July 9, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30001755/familial-clustering-of-cardiac-conditions-in-patients-with-anomalous-aortic-origin-of-a-coronary-artery-and-myocardial-bridges
#6
Hitesh Agrawal, Carlos M Mery, S Kristen Sexson Tejtel, Charles D Fraser, E Dean McKenzie, Athar M Qureshi, Silvana Molossi
BACKGROUND: Anomalous aortic origin of a coronary artery is the second leading cause of sudden cardiac arrest/death in young athletes in the United States of America. Limited data are available regarding family history in this patient population. METHODS: Patients were evaluated prospectively from 12/2012 to 02/2017 in the Coronary Anomalies Program at Texas Children's Hospital. Relevant family history included the presence of CHD, sudden cardiac arrest/death, arrhythmia/pacemaker use, cardiomyopathy, and atherosclerotic coronary artery disease before the age of 50 years...
July 13, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30001363/role-of-the-streptococcus-suis-serotype-2-capsular-polysaccharide-in-the-interactions-with-dendritic-cells-is-strain-dependent-but-remains-critical-for-virulence
#7
Jean-Philippe Auger, Dominic Dolbec, David Roy, Mariela Segura, Marcelo Gottschalk
Streptococcus suis serotype 2 is an important porcine bacterial pathogen and zoonotic agent responsible for sudden death, septic shock, and meningitis. However, serotype 2 strains are heterogeneous, composed of a multitude of sequence types (STs) whose distribution greatly varies worldwide. Of the virulence factors presently described for S. suis, the capsular polysaccharide (CPS) is a critical factor implicated in a multitude of functions, including in impairment of phagocytosis and innate immune cell activation by masking underlying bacterial components...
2018: PloS One
https://www.readbyqxmd.com/read/29997977/mechanism-of-death-there-s-more-to-it-than-sudden-cardiac-arrest
#8
David C Parish, Hemant Goyal, Francis C Dane
No abstract text is available yet for this article.
May 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29997564/editorial-sudden-death-in-epilepsy-basic-and-translational-research
#9
EDITORIAL
Christopher M DeGiorgio
No abstract text is available yet for this article.
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29997012/black-athlete-electrocardiographic-repolarization-pattern
#10
REVIEW
Michael J Hermelin, Jordan M Prutkin
There is debate over the use of the electrocardiogram (ECG) to screen athletes for disorders associated with sudden cardiac death, but if screening is completed, accurate ECG interpretation is important. Recently, there has been recognition of a normal black athlete repolarization pattern which includes J-point elevation, convex ST-segment elevation, and T-wave inversions in leads V1 to V4 occurring in 5-15% of black athletes. This pattern must be differentiated from T-wave inversions that are associated with hypertrophic cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy...
July 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29997001/evaluation-of-t-wave-alternans-in-pediatric-patients-with-chronic-renal-failure
#11
Olgu Hallioglu, Meryem Keceli, Gulcin Bozlu, Ali Delibas, Derya Karpuz, Hüseyin Selvi
INTRODUCTION: Microvolt T-wave alternans (TWA) is known to be useful in prediction of ischemia and sudden death in high-risk populations and there are no studies in children with chronic renal failure (CRF). Cardiac problems seem to be responsible for an important part of death in children and young adults with CRF. The aim of this study is to evaluate Holter microvolts TWA measurements in children with CRF comparing to the control group. METHODS: This prospective study included 40 patients with CRF and 48 healthy controls...
July 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29997000/self-terminating-ventricular-fibrillation-recorded-by-an-implantable-loop-recorder-as-a-cause-of-syncope-a-case-report
#12
Paulina Przyżycka, Michał Kałowski, Izabela Poddębska, Krzysztof Kaczmarek, Paweł Ptaszyński, Jerzy K Wranicz, Iwona Cygankiewicz
Ventricular fibrillation (VF) is the most common arrhythmia leading to sudden cardiac death, but in rare cases VF can manifest as a syncope, provided that it will self-terminate. We present a case of a 45-year old female with a history of unexplained syncopal episodes despite exhaustive diagnostics. Implantable loop recorder documented an episode of idiopathic, self-terminating VF as a cause of syncope.
July 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29996990/ecg-markers-of-arrythmogenic-risk-relationships-with-pericardial-fat-volume-and-bmi-in-patients-with-coronary-atherosclerosis
#13
Abdulameer A Al-Mosawi, Hussein Nafakhi, Mohammed Bader Hassan, Mohammed Alareedh, Hasan A Al-Nafakh
BACKGROUND: Several novel ECG markers are proposed to predict the risk of sudden cardiac death in several clinical conditions in the recent years. However, little is known about the association of pericardial fat or obesity with these markers. OBJECTIVES: To assess the possible relationship between pericardial fat volume (PFV) and body mass index (BMI) with novel ECG markers (Tp-e, Tp-e/QT, Tp-e/QTc*QRS and QTc/QRS) in patients with coronary atherosclerosis. PATIENTS AND METHODS: We enrolled 100 patients with suspected coronary artery disease who underwent 64-slice multi-detector CT angiography...
July 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29996190/-analysis-of-four-carnitine-acylcarnitine-translocase-deficiency-cases-caused-by-homozygous-mutation-of-slc25a20-c-199-10t-g
#14
X Fan, B B Xie, Q Zhang, S Yi, G X Geng, Q Yang, J S Luo, J Wang, C Li, S K Chen, Y P Shen
Objective: To investigate the clinical, biochemical and genetic features of four carnitine-acylcarnitine translocase deficiency cases. Methods: Four cases diagnosed with carnitine-acylcarnitine translocase deficiency from Guangxi Maternal and Child Health Hospital were studied. DNA was extracted from dry blood filter for gene analysis. SLC25A20 gene analysis was performed in 1 case and the whole exon sequence analysis was performed in 3 cases. Results: Retrospective study on unrelated carnitine-acylcarnitine translocase deficiency patients, the age of onset was 1-28 d, the age of death were 1...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29995277/genetics-of-and-pathogenic-mechanisms-in-arrhythmogenic-right-ventricular-cardiomyopathy
#15
REVIEW
Anita Kiran Vimalanathan, Elisabeth Ehler, Katja Gehmlich
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease, associated with a high risk of sudden cardiac death. ARVC has been termed a 'disease of the desmosome' based on the fact that in many cases, it is caused by mutations in genes encoding desmosomal proteins at the specialised intercellular junctions between cardiomyocytes, the intercalated discs. Desmosomes maintain the structural integrity of the ventricular myocardium and are also implicated in signal transduction pathways...
July 11, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29994685/quantification-of-ventricular-repolarization-variation-for-sudden-cardiac-death-risk-stratification-in-atrial-fibrillation
#16
Alba Martin-Yebra, Pablo Laguna, Iwona Cygankiewicz, Antonio Bayes de Luna, Enrico Gianluca Caiani, Juan Pablo Martinez
OBJECTIVE: Atrial fibrillation (AF) rhythm gives rise to an irregular response in ventricular activity, preventing the use of standard ECG-derived risk markers based on ventricular repolarization heterogeneity under this particular condition. In this study we proposed new indices to quantify repolarization variations in AF patients, assessing their stratification performance in a chronic heart failure (CHF) population with AF. METHODS: We developed a method based on a selective bin averaging technique...
June 28, 2018: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/29992490/evaluation-of-cardiovascular-disease-risk-in-hiv-1-infected-patients-treated-with-darunavir
#17
Magda Opsomer, Dessislava Dimitrova, Johan Verspeelt, Amy Purrington, Abdul Mehbob, Scott Chavers, Helen Pai, Simon Vanveggel, Donghan Luo, Kimberley Brown, Christiane Moecklinghoff, Richard E Nettles, Katia Boven
INTRODUCTION: We evaluated cardiovascular disease (CVD) risk associated with darunavir treatment and examined the demographic/clinical characteristics of darunavir users based on data from Janssen-sponsored clinical trials, post-marketing pharmacovigilance databases, and administrative claims databases. METHODS: First, selected CVD events [myocardial infarction, stroke, sudden death, invasive cardiovascular procedures (coronary artery angioplasty or bypass, or carotid endarterectomy)] were analyzed in 19 Janssen-sponsored phase 2-4 studies (incidence rates estimated from pooled data; 95% confidence intervals derived from Poisson distribution)...
July 10, 2018: Drugs in R&D
https://www.readbyqxmd.com/read/29992057/incidental-finding-of-the-anomalous-origin-of-left-main-coronary-artery-from-pulmonary-artery-in-an-adult-presenting-with-arrhythmia-induced-myocardial-ischemia
#18
Shantanu Patil, Mahek Shah, Brijesh Patel, Lohit Garg, Larry Jacobs, Nauman Islam, Matthew Martinez
Anomalous origin of the left main coronary artery from the pulmonary artery (ALCAPA) is a rare congenital coronary anomaly with high mortality. It is associated with cardiovascular complications and is usually diagnosed soon after birth. Those who survive into adulthood can present with signs of myocardial infarction, heart failure, mitral regurgitation, severe pulmonary hypertension, or sudden cardiac death. We present a 53-year-old female presenting with atrial fibrillation and found to have an incidental diagnosis of ALCAPA who refused surgical correction...
2018: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29991101/single-coronary-artery-arising-from-the-right-sinus-of-valsalva-and-the-role-of-coronary-computed-tomography-angiography
#19
Amornpol Anuwatworn, Pratima Karta, Jimmy Yee, Shenjing Li, Vishesh Kumar, Kelly Steffen
There are many variations of coronary anatomy encountered during coronary angiogram. Anatomy demonstrating a single coronary artery is a rare congenital coronary artery anomaly. The entire heart is supplied solely by a coronary artery with single coronary ostium. We present a rare case of single coronary artery arising from the right sinus of Valsalva. The patient had presented with atypical chest pain and a stress test was performed, which was abnormal. We proceeded with coronary angiography which showed a common ostium of the right and left coronary artery coming from the right coronary cusp...
March 2018: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29989929/automated-detection-of-post-ictal-generalized-eeg-suppression
#20
Wanchat Theeranaew, James McDonald, Bilal Zonjy, Farhad Kaffashi, Brian Moseley, Daniel Friedman, Elson So, James X Tao, Maromi Nei, Philippe Ryvlin, Rainer Surges, Roland D Thijs, Stephan Schuele, Samden Lhatoo, Kenneth Loparo
Post-ictal generalized EEG suppression (PGES) is a potential Electroencephalographic (EEG) biomarker for risk of Sudden Unexpected Death in Epilepsy (SUDEP). PGES is an epoch of EEG inactivity after a seizure, and the detection of PGES in clinical data is extremely difficult due to artifacts from breathing, movement and muscle activity that can adversely affect the quality of the recorded EEG data. Even clinical experts visually interpreting the EEG will have diverse opinions on the start and end of PGES for a given patient...
November 9, 2017: IEEE Transactions on Bio-medical Engineering
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