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https://www.readbyqxmd.com/read/28917970/how-do-enzymes-meet-nanoparticles-and-nanomaterials
#1
REVIEW
Ming Chen, Guangming Zeng, Piao Xu, Cui Lai, Lin Tang
Enzymes are fundamental biological catalysts responsible for biological regulation and metabolism. The opportunity for enzymes to 'meet' nanoparticles and nanomaterials is rapidly increasing due to growing demands for applications in nanomaterial design, environmental monitoring, biochemical engineering, and biomedicine. Therefore, understanding the nature of nanomaterial-enzyme interactions is becoming important. Since 2014, enzymes have been used to modify, degrade, or make nanoparticles/nanomaterials, while numerous nanoparticles/nanomaterials have been used as materials for enzymatic immobilization and biosensors and as enzyme mimicry...
September 13, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28915469/synthesis-of-water-soluble-curcumin-derivatives-and-their-inhibition-on-lysozyme-amyloid-fibrillation
#2
Sujuan Wang, Xixi Peng, Liangliang Cui, Tongtong Li, Bei Yu, Gang Ma, Xinwu Ba
The potential application of curcumin was heavily limited in biomedicine because of its poor solubility in pure water. To circumvent the detracting feature, two novel water-soluble amino acid modified curcumin derivatives (MLC and DLC) have been synthesized through the condensation reaction between curcumin and N(α)-Fmoc-N(ε)-Boc-l-lysine. Benefiting from the enhanced solubility of 3.32×10(-2)g/mL for MLC and 4.66×10(-2)g/mL for DLC, the inhibition effects of the as-prepared derivatives on the amyloid fibrillation of lysozyme (HEWL) were investigated detaily in water solution...
September 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28915042/mode-of-peg-coverage-on-carbon-nanotubes-affects-binding-of-innate-immune-protein-c1q
#3
Agathe Belime, Edmond Gravel, Sophie Brenet, Sarah Ancelet, Charlotte Caneiro, Yanxia Hou, Nicole Thielens, Eric Doris, Wai Li Ling
Surface modification of nanoparticles with poly(ethylene glycol) PEG is used in biomedicines to increase the circulation time of the particles after intravenous injection. Here, we study the interaction of PEG-covered carbon nanotubes (CNTs) with the serum complement protein C1q. Besides being the target-recognizing unit of the initiating complex for the classical pathway of complement in our innate immune system, C1q is involved in a range of important physiological processes. We modified the surface of multi-walled CNTs with covalently grafted PEG and physically adsorbed PEG...
September 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28913771/criminal-prohibition-of-wrongful-re%C3%A2-identification-legal-solution-or-minefield-for-big-data
#4
Mark Phillips, Edward S Dove, Bartha M Knoppers
The collapse of confidence in anonymization (sometimes also known as de-identification) as a robust approach for preserving the privacy of personal data has incited an outpouring of new approaches that aim to fill the resulting trifecta of technical, organizational, and regulatory privacy gaps left in its wake. In the latter category, and in large part due to the growth of Big Data-driven biomedical research, falls a growing chorus of calls for criminal and penal offences to sanction wrongful re-identification of "anonymized" data...
September 14, 2017: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/28913530/why-microfluidics-merits-and-trends-in-chemical-synthesis
#5
REVIEW
Yong Liu, Xingyu Jiang
The intrinsic limitations of conventional batch synthesis have hindered its applications in both solving classical problems and exploiting new frontiers. Microfluidic technology offers a new platform for chemical synthesis toward either molecules or materials, which has promoted the progress of diverse fields such as organic chemistry, materials science, and biomedicine. In this review, we focus on the improved performance of microreactors in handling various situations, and outline the trend of microfluidic synthesis (microsynthesis, μSyn) from simple microreactors to integrated microsystems...
September 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28912242/fabrication-of-fillable-microparticles-and-other-complex-3d-microstructures
#6
Kevin J McHugh, Thanh D Nguyen, Allison R Linehan, David Yang, Adam M Behrens, Sviatlana Rose, Zachary L Tochka, Stephany Y Tzeng, James J Norman, Aaron C Anselmo, Xian Xu, Stephanie Tomasic, Matthew A Taylor, Jennifer Lu, Rohiverth Guarecuco, Robert Langer, Ana Jaklenec
Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing...
September 15, 2017: Science
https://www.readbyqxmd.com/read/28905079/-falsified-medicines-in-parallel-trade
#7
REVIEW
Heide Muckenfuß
The number of falsified medicines on the German market has distinctly increased over the past few years. In particular, stolen pharmaceutical products, a form of falsified medicines, have increasingly been introduced into the legal supply chain via parallel trading. The reasons why parallel trading serves as a gateway for falsified medicines are most likely the complex supply chains and routes of transport. It is hardly possible for national authorities to trace the history of a medicinal product that was bought and sold by several intermediaries in different EU member states...
September 13, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28904328/a-narrative-review-of-non-operative-treatment-especially-traditional-chinese-medicine-therapy-for-lumbar-intervertebral-disc-herniation
#8
Bo Zhang, Haidong Xu, Juntao Wang, Bin Liu, Guodong Sun
Lumbar intervertebral disc herniation (LIDH), as the main contributor to low back pain and sciatica, imposes a heavy burden on both the individual and society. Non-operative treatment or conservative treatment has proven effective in alleviation of the symptoms of LIDH and are considered to be a first-line choice for most cases. Active lifestyle, physical therapy, complementary and alternative medicine therapy or Traditional Chinese medicine (TCM) therapy, and pharmacotherapy are routinely used as effective non-operative treatment for LIDH patients...
2017: Bioscience Trends
https://www.readbyqxmd.com/read/28902492/rheotaxis-of-bimetallic-micromotors-driven-by-chemical-acoustic-hybrid-power
#9
Liqiang Ren, Dekai Zhou, Zhangming Mao, Pengtao Xu, Tony Jun Huang, Thomas E Mallouk
Rheotaxis is a common phenomenon in nature that refers to the directed movement of microorganisms as a result of shear flow. The ability to mimic natural rheotaxis using synthetic micro/nanomotors adds functionality to enable their applications in biomedicine and chemistry. Here we present a hybrid strategy that can achieve both positive and negative rheotaxis of synthetic bimetallic micromotors by employing a combination of chemical fuel and acoustic force. An acoustofluidic device is developed for the integration of the two propulsion mechanisms...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28901868/calculable-people-standardising-assessment-guidelines-for-alzheimer-s-disease-in-1980s-britain
#10
Duncan Wilson
This article shows how funding research on Alzheimer's disease became a priority for the British Medical Research Council (MRC) in the late 1970s and 1980s, thanks to work that isolated new pathological and biochemical markers and showed that the disease affected a significant proportion of the elderly population. In contrast to histories that focus on the emergence of new and competing theories of disease causation in this period, I argue that concerns over the use of different assessment methods ensured the MRC's immediate priority was standardising the ways in which researchers identified and recorded symptoms of Alzheimer's disease in potential research subjects...
October 2017: Medical History
https://www.readbyqxmd.com/read/28901846/applications-of-nanoflowers-in-biomedicine
#11
Hossein Heli, Masoud Negahdary
BACKGROUND: Nanotechnology has opened new windows for biomedical researches and treatment of diseases. Nanostructures with flower-like shapes (nanoflowers) which have exclusive morphology and properties have been interesting for many researchers. METHODS: In this review, various applications of nanoflowers in biomedical researches and patents from various aspects have been investigated and reviewed. RESULTS: Nanoflowers attracted serious attentions in whole of biomedical fields such as cardiovascular diseases, microbiology, sensors and biosensors, biochemical and cellular studies, cancer therapy, healthcare and etc...
September 11, 2017: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/28901273/oleuropein-molecular-dynamics-and-computation
#12
Luigi Gentile, Nicola A Uccella, Ganapathy Sivakumar
Olive oil and table olive biophenols have been shown to significantly enrich the hedonic-sensory and nutritional quality of the Mediterranean diet. Oleuropein is one of the predominate biophenols in green olives and leaves, which not only has noteworthy free-radical quenching activity but also putatively reduces the incidence of various cancers. Clinical trials suggest that the consumption of extra virgin olive oil reduces the risk of several degenerative diseases. The oleuropein-based bioactives in olive oil could reduce tumor necrosis factor α, interleukin-1β and nitric oxide...
September 11, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28901172/traditional-manual-acupuncture-combined-with-rehabilitation-therapy-for-shoulder-hand-syndrome-after-stroke-within-the-chinese-healthcare-system-a-systematic-review-and-meta-analysis
#13
Le Peng, Chao Zhang, Lan Zhou, Hong-Xia Zuo, Xiao-Kuo He, Yu-Ming Niu
OBJECTIVE: To investigate the effectiveness of traditional manual acupuncture combined with rehabilitation therapy versus rehabilitation therapy alone for shoulder hand syndrome after stroke. DATA SOURCES: PubMed, EMBASE, the Cochrane Library, Chinese Biomedicine Database, China National Knowledge Infrastructure, VIP Information Database, Wan Fang Database and reference lists of the eligible studies were searched up to July 2017 for relevant studies. METHODS: Randomized controlled trials that compared the combined effects of traditional manual acupuncture and rehabilitation therapy to rehabilitation therapy alone for shoulder hand syndrome after stroke were included...
September 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28900505/iron-oxide-nanozyme-a-multifunctional-enzyme-mimetic-for-biomedical-applications
#14
REVIEW
Lizeng Gao, Kelong Fan, Xiyun Yan
Iron oxide nanoparticles have been widely used in many important fields due to their excellent nanoscale physical properties, such as magnetism/superparamagnetism. They are usually assumed to be biologically inert in biomedical applications. However, iron oxide nanoparticles were recently found to also possess intrinsic enzyme-like activities, and are now regarded as novel enzyme mimetics. A special term, "Nanozyme", has thus been coined to highlight the intrinsic enzymatic properties of such nanomaterials...
2017: Theranostics
https://www.readbyqxmd.com/read/28900211/the-controllable-destabilization-route-for-synthesis-of-low-cytotoxic-magnetic-nanospheres-with-photonic-response
#15
Yulia I Andreeva, Andrey S Drozdov, Anna F Fakhardo, Nikolay A Cheplagin, Alexander A Shtil, Vladimir V Vinogradov
We present a new approach for obtaining magnetic nanospheres with tunable size and high magnetization. The method is implemented via controllable destabilization of a stable magnetite hydrosol with glycerol, leading to the formation of aggregates followed by their stabilization with the citrate shell. This inexpensive, simple and easily scalable approach required no special equipment. The obtained samples were characterized by high stability and magnetization over 80 emu/g. Effects of synthetic conditions on physicochemical properties of nanospheres were monitored by hydrodynamic size, zeta potential, and polydispersity of magnetite aggregates...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899488/investigating-the-structural-and-functional-features-of-representative-recombinants-of-chondroitinase-abc-i
#16
Khadijeh Moradi, Seyedeh Akram Shirdel, Masoumeh Shamsi, Vahab Jafarian, Khosrow Khalifeh
Chondroitin Sulfate Proteoglycans (CSPGs) are the main inhibitors for axon regeneration after damaging of Central Nervous System (CNS). Chondroitinase ABC I (cABC I) can degrade CSPGs by removing chondroitin and dermatan sulfate side chains from proteoglycans. Hence, it may be considered as an attractive candidate in biomedicine. For practical applications of this enzyme, increasing the effective circulating level and reducing the number and volume of injections for patients is one of the main concerns which is directly related to conformational stability and catalytic efficiency of the enzyme...
December 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28898479/synthesis-of-coordination-polymer-nanoparticles-using-self-assembled-block-copolymers-as-template
#17
Birgit Weber
Nowadays there is a high demand in specialized functional materials e.g. for applications as sensors in biomedicine. For the realization of such applications, nano-structures and the integration in a composite matrix are indispensable. Coordination polymers and networks, for example with spin crossover properties, are a highly promising family of switchable materials where the switching process can be triggered by various external stimuli. An overview over different strategies for the synthesis of nanoparticles of such systems is given...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28892587/chemical-modification-improves-biocompatibility-of-black-phosphorus-nanosheets
#18
Guangbo Qu, Wei Liu, Yuetao Zhao, Jie Gao, Tian Xia, Jianbo Shi, Ligang Hu, Wenhua Zhou, Jiejun Gao, Huaiyu Wang, Qian Luo, Qunfang Zhou, Sijin Liu, Xuefeng Yu, Guibin Jiang
Black phosphorus nanosheets (BPs) have exhibited great potential for various applications including biomedicine, thus their potential side effects and corresponding improvement strategy deserve investigation. Here, in vitro and in vivo biological effects of BPs with and without titanium sulfonate ligand (TiL4) modification are investigated. Comparing to bare BPs, BPs with TiL4 modification (TiL4@BPs) can efficiently escape from macrophages uptake, and reduce the cytotoxicity and proinflammation. When intravenously injected into mice, bare BPs trigger significant inflammatory responses, including an increase in peripheral neutrophils accompanied by elevation of a group of inflammatory cytokines, while TiL4@BPs exhibit no such adverse immune responses...
September 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28891052/international-publication-trends-originating-from-anaesthetic-departments-from-2001-to-2015
#19
J Ausserer, C Miller, G Putzer, D Pehböck, P Hamm, V Wenzel, P Paal
The aim of this study was to analyse publication trends from the anaesthetic literature of the G-20 countries. We performed a literature search in Medline to identify articles related to anaesthetic departments published between 2001 and 2015, by specific G-20 countries according to the affiliation field of the authors, and to three time periods 2001-2005, 2006-2010 and 2011-2015. The number of articles, number of original articles (vs. reviews, editorials or correspondence), articles per million inhabitants, and citations per article were analysed...
October 2017: Anaesthesia
https://www.readbyqxmd.com/read/28890161/self-assembly-of-repeat-proteins-concepts-and-design-of-new-interfaces
#20
Daniel Sanchez-deAlcazar, Sara H Mejias, Kevin Erazo, Begoña Sot, Aitziber L Cortajarena
In Nature, assembled protein structures offer the most complex functional structures. The understanding of the mechanisms ruling protein-protein interactions opens the door to manipulate protein assemblies in a rational way. Proteins are versatile scaffolds with great potential as tools in nanotechnology and biomedicine because of their chemical, structural, and functional versatility. Currently, bottom-up self-assembly based on biomolecular interactions of small and well-defined components, is an attractive approach to biomolecular engineering and biomaterial design...
September 7, 2017: Journal of Structural Biology
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