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https://www.readbyqxmd.com/read/29155378/50-years-to-gender-parity-can-stem-afford-to-wait-a-cardiologist-and-nih-chief-officer-of-scientific-workforce-diversity-reflects-on-what-it-will-take-to-keep-women-in-biomedicine
#1
Hannah A Valantine
The first spark of my desire to become a cardiologist came, believe it or not, in a third-grade art class where I was asked to draw and color the circulation of blood as depicted by 16th-century English physician William Harvey. This task enraptured me-seeing that something so beautiful could work so flawlessly. So, many years later, I remain intrigued by cardiac transplantation, the subspecialty in which I ultimately chose to anchor my career as a physician scientist. Each day I live in awe of the fact that you can remove someone's organ, place it in another, and still have that organ work beautifully, most of the time...
November 2017: IEEE Pulse
https://www.readbyqxmd.com/read/29149859/medicinal-plants-used-by-women-in-mecca-urban-muslim-and-gendered-knowledge
#2
Afnan Alqethami, Julie A Hawkins, Irene Teixidor-Toneu
BACKGROUND: This study explores medicinal plant knowledge and use among Muslim women in the city of Mecca, Saudi Arabia. Ethnobotanical research in the region has focused on rural populations and male herbal healers in cities, and based on these few studies, it is suggested that medicinal plant knowledge may be eroding. Here, we document lay, female knowledge of medicinal plants in an urban centre, interpreting findings in the light of the growing field of urban ethnobotany and gendered knowledge and in an Islamic context...
November 17, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29146498/synthesis-and-characterization-of-silver-nanoparticles-using-gelidium-amansii-and-its-antimicrobial-property-against-various-pathogenic-bacteria
#3
Arivalagan Pugazhendhi, Desika Prabakar, Jaya Mary Jacob, Indira Karuppusamy, Rijuta Ganesh Saratale
Microfouling is evolving at a fast rate causing augmented mortality rates and damage worldwide. Until now, several remedial measures have been exploited to overcome microfouling, amongst them nanoparticles play a superior role. Currently, green synthesized nanoparticles have been centered owing to its eco-friendly, cost effectively and non-toxic nature which has also increased its industrial applications (biomedicine, food and textile). In the present research Silver Nanoparticles (Ag NPs) synthesized using marine red algae Gelidium amansii...
November 13, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29145727/directly-observing-micelle-fusion-and-growth-in-solution-by-liquid-cell-transmission-electron-microscopy
#4
Lucas R Parent, Evangelos Bakalis, Abelardo Ramírez-Hernández, Jacquelin K Kammeyer, Chiwoo Park, Juan de Pablo, Francesco Zerbetto, Joseph P Patterson, Nathan C Gianneschi
Amphiphilic small molecules and polymers form commonplace nanoscale macromolecular compartments and bilayers, and as such are truly essential components in all cells and in many cellular processes. The nature of these architectures, including their formation, phase changes, and stimuli-response behaviors, is necessary for the most basic functions of life, and over the past half-century, these natural micellar structures have inspired a vast diversity of industrial products, from biomedicines to detergents, lubricants, and coatings...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29145481/amiloride-enhanced-gene-transfection-of-octa-arginine-functionalized-calcium-phosphate-nanoparticles
#5
Juan Ramón Vanegas Sáenz, Taichi Tenkumo, Yuya Kamano, Hiroshi Egusa, Keiichi Sasaki
Nanoparticles represent promising gene delivery systems in biomedicine to facilitate prolonged gene expression with low toxicity compared to viral vectors. Specifically, nanoparticles of calcium phosphate (nCaP), the main inorganic component of human bone, exhibit high biocompatibility and good biodegradability and have been reported to have high affinity for protein or DNA, having thus been used as gene transfer vectors. On the other hand, Octa-arginine (R8), which has a high permeability to cell membrane, has been reported to improve intracellular delivery systems...
2017: PloS One
https://www.readbyqxmd.com/read/29145282/autosomal-dominant-polycystic-kidney-disease-combined-with-hypertrophic-cardiomyopathy-a-case-report
#6
Yingjing Shen, Chenggang Xu
INTRODUCTION: This report describes the novel sampling of autosomal dominant polycystic kidney disease (ADPKD) combined with hypertrophic cardiomyopathy (HCM). SYMPTOMS AND CLINICAL FINDINGS: A 48-year-old Chinese man presented with anasarca, hypourocrinia, gross hematuria, and weight gain by 10 kg subsequently developed acute kidney injury after struck by acute respiratory distress syndrome, really a threat to his heart. DIAGNOSES: Abdominal ultrasound revealed multiple small cysts in both kidneys, with the right kidney measuring 11...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29143236/the-making-of-informed-choice-in-midwifery-a-feminist-experiment-in-care
#7
Margaret E MacDonald
This paper is about the clinical principle of informed choice-the hallmark feature of the midwifery model of care in Ontario, Canada. Drawing on ethnographic history interviews with midwives, I trace the origins of the idea of informed choice to its roots in the social movement of midwifery in North America in the late 1960s and 1970s. At that time informed choice was not the distinctive feature of midwifery but was deeply embedded what I call midwifery's feminist experiment in care. But as midwifery in Ontario transitioned from a social movement to a full profession within the formal health care system, informed choice was strategically foregrounded in order to make the midwifery model of care legible and acceptable to a skeptical medical profession, conservative law makers, and a mainstream clientele...
November 15, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29141536/development-and-tailoring-of-hybrid-lipid-nanocarriers
#8
German A Islan, Maximiliano L Cacicedo, Boris Rodenak-Kladniew, Nelson Duran, Guillermo R Castro
BACKGROUND: Lipid nanoparticles are considered one of the most promising systems for controlled release of therapeutic molecules highly hydrophobic and with low biodisponibility. Solid lipid nanoparticles and nanostructured lipids carriers are widely seen as the workhorses of drug delivery systems because of low toxicity, enhanced encapsulation capacity, controlled drug kinetic release, easy tailoring and targeting and practicable scale up. CONCLUSIONS: A new generation of hybrid lipid nanoparticles has emerged by combining the lipidic properties with polymers, proteins and metallic structures...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29131565/protein-based-3d-microstructures-with-controllable-morphology-and-ph-responsive-properties
#9
Shuxin Wei, Jie Liu, Yuanyuan Zhao, Tingbin Zhang, Mei-Ling Zheng, Feng Jin, Xianzi Dong, Jinfeng Xing, Xuanming Duan
The microtechnology of controlling stimuli-responsive biomaterials at micrometer scale is crucial for biomedical applications. Here, we report bovine serum albumin (BSA)-based three-dimensional (3D) microstructures with tunable surface morphology and pH-responsive properties via two-photon polymerization (TPP) microfabrication technology. The laser processing parameters including laser power, scanning speed and layer distance are optimized for the fabrication of well-defined 3D BSA microstructures. The tunable morphology of BSA microstructures and a wide range pH response corresponding to the swelling ratio from 1...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29130947/application-of-digital-pcr-in-detecting-human-diseases-associated-gene-mutation
#10
Yu Tong, Shizhen Shen, Hui Jiang, Zhi Chen
Gene mutation has been considered a research hotspot, and the rapid development of biomedicine has enabled significant advances in the evaluation of gene mutations. The advent of digital polymerase chain reaction (dPCR) elevates the detection of gene mutations to unprecedented levels of precision, especially in cancer-associated genes. dPCR has been utilized in the detection of tumor markers in cell-free DNA (cfDNA) samples from patients with different types of cancer in samples such as plasma, cerebrospinal fluid, urine and sputum, which confers significant value for dPCR in both clinical applications and basic research...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29126230/a-survey-of-software-tools-for-microrna-discovery-and-characterization-using-rna-seq
#11
Michele Bortolomeazzi, Enrico Gaffo, Stefania Bortoluzzi
Since the small RNA-sequencing (sRNA-seq) technology became available, it allowed the discovery of thousands new microRNAs (miRNAs) in humans and many other species, providing new data on these small RNAs (sRNAs) of high biological and translational relevance. MiRNA discovery has not yet reached saturation, even in the most studied model organisms, and many researchers are using sRNA-seq in studies with different aims in biomedicine, fundamental research and in applied animal sciences. We review several miRNA discovery and characterization software tools that implement different strategies, providing a useful guide for researchers to select the programs best suiting their study objectives and data...
November 6, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29126166/fabrication-of-circular-assemblies-with-dna-tetrahedrons-from-static-structures-to-a-dynamic-rotary-motor
#12
Liying Wang, Zhenyu Meng, Felicia Martina, Huilin Shao, Fangwei Shao
DNA tetrahedron as the simplest 3D DNA nanostructure has been applied widely in biomedicine and biosensing. Herein, we design and fabricate a series of circular assemblies of DNA tetrahedron with high purity and decent yields. These circular nanostructures are confirmed by endonuclease digestion, gel electrophoresis and atomic force microscopy. Inspired by rotary protein motor, we demonstrate these circular architectures can serve as a stator for a rotary DNA motor to achieve the circular rotation. The DNA motor can rotate on the stators for several cycles, and the locomotion of the motor is monitored by the real-time fluorescent measurements...
November 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29124869/polydopamine-based-colloidal-materials-synthesis-and-applications
#13
REVIEW
Ziwei Deng, Bin Shang, Bo Peng
Polydopamine is a synthetic analogue of natural melanin (eumelanin) produced from oxidative polymerization of dopamine. Owing to its strong adhesion ability, versatile chemical reactivity, biocompatibility and biodegradation, polydopamine is commonly applied as a versatile linker to synthesize colloidal materials with diverse structures, unique physicochemical properties and tunable functions, which allow for a broad scope of applications including biomedicine, sensing, catalysis, environment and energy. In this personal account, we discuss first about the different synthetic approaches of polydopamine, as well as its polymerization mechanism, and then with a comprehensive overview of recent progress in the synthesis and applications of polydopamine-based colloidal materials...
November 10, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29124842/porous-polyelectrolytes-charge-pores-for-more-functionalities
#14
Weiyi Zhang, Qiang Zhao, Jiayin Yuan
The past decade has witnessed rapid advances in porous polyelectrolytes and there is tremendous ongoing interest in their synthesis and applications in environment, energy, biomedicine and catalysis. The porous polyelectrolytes research is motivated by the synergy of, apart from the flexible choice of functional organic groups and processing technologies, the charge and pores spanning length scales from individual polyelectrolyte backbones to their nano/micro superstructures. This review surveys recent progresses on porous polyelectrolytes including membranes, particles, scaffolds, high surface area powders/resins, and their derivatives...
November 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29119870/current-and-emerging-global-themes-in-the-bioethics-of-regenerative-medicine-the-tangled-web-of-stem-cell-translation
#15
Sarah Chan
Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the stem cell therapy landscape and argue that while the sale of unproven therapies undoubtedly poses ethical concerns, it must be understood as part of a larger problem at the interface between biomedicine, healthcare, publics, policy and the market...
October 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29119244/enterovirus-associated-changes-in-blood-transcriptomic-profiles-of-children-with-genetic-susceptibility-to-type-1-diabetes
#16
Niina Lietzen, Le T T An, Maria K Jaakkola, Henna Kallionpää, Sami Oikarinen, Juha Mykkänen, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari, Heikki Hyöty, Riitta Lahesmaa, Laura L Elo
AIMS/HYPOTHESIS: Enterovirus infections have been associated with the development of type 1 diabetes in multiple studies, but little is known about enterovirus-induced responses in children at risk for developing type 1 diabetes. Our aim was to use genome-wide transcriptomics data to characterise enterovirus-associated changes in whole-blood samples from children with genetic susceptibility to type 1 diabetes. METHODS: Longitudinal whole-blood samples (356 samples in total) collected from 28 pairs of children at increased risk for developing type 1 diabetes were screened for the presence of enterovirus RNA...
November 8, 2017: Diabetologia
https://www.readbyqxmd.com/read/29118363/influence-of-hydrocarbon-oil-structure-on-adjuvanticity-and-autoimmunity
#17
Anthony C Y Yau, Erik Lönnblom, Jianghong Zhong, Rikard Holmdahl
Mineral oils are extensively used in our daily life, in food, cosmetics, biomedicine, vaccines and in different industrial applications. However, exposure to these mineral oils has been associated with immune adjuvant effects and the development of autoimmune diseases. Here we investigate the structural impacts of the hydrocarbon oil molecules on their adjuvanticity and autoimmunity. First, we showed that hydrocarbon oil molecules with small atomic differences could result in experimental arthritis in DA rats differing in disease severity, incidence, weight change and serum levels of acute phase proteins...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118272/beyond-cancer-genes-colorectal-cancer-as-robust-intrinsic-states-formed-by-molecular-interactions
#18
Ruoshi Yuan, Suzhan Zhang, Jiekai Yu, Yanqin Huang, Demin Lu, Runtan Cheng, Sui Huang, Ping Ao, Shu Zheng, Leroy Hood, Xiaomei Zhu
Colorectal cancer (CRC) has complex pathological features that defy the linear-additive reasoning prevailing in current biomedicine studies. In pursuing a mechanistic understanding behind such complexity, we constructed a core molecular-cellular interaction network underlying CRC and investigated its nonlinear dynamical properties. The hypothesis and modelling method has been developed previously and tested in various cancer studies. The network dynamics reveal a landscape of several attractive basins corresponding to both normal intestinal phenotype and robust tumour subtypes, identified by their different molecular signatures...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29116062/-biobanks-as-the-basis-for-developing-biomedicine-problems-and-prospects
#19
O N Reznik, D O Kuzmin, A O Reznik
Biobanking is crucial for the development of life sciences in general and biomedical science in particular. A systematic study of stored biomaterials enables the discovery of new biomarkers for various physiological and pathophysiological states, identification of the drug targets, and validation of these findings in human population studies. During the last decades, the importance of biobanking has increased in parallel with the growth in their size from relatively small collections to very large national and international biorepositories...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29113773/pairing-cancer-biomarkers-to-biomedicine
#20
EDITORIAL
Seung Ho Shin, Zigang Dong
No abstract text is available yet for this article.
November 2017: EBioMedicine
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