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https://www.readbyqxmd.com/read/28329003/effects-of-research-complexity-and-competition-on-the-incidence-and-growth-of-coauthorship-in-biomedicine
#1
Jason Cory Brunson, Xiaoyan Wang, Reinhard C Laubenbacher
BACKGROUND: Investigations into the factors behind coauthorship growth in biomedical research have mostly focused on specific disciplines or journals, and have rarely controlled for factors in combination or considered changes in their effects over time. Observers often attribute the growth to the increasing complexity or competition (or both) of research practices, but few attempts have been made to parse the contributions of these two likely causes. OBJECTIVES: We aimed to assess the effects of complexity and competition on the incidence and growth of coauthorship, using a sample of the biomedical literature spanning multiple journals and disciplines...
2017: PloS One
https://www.readbyqxmd.com/read/28326227/uptake-of-the-proteins-htra1-and-htra2-by-cells-mediated-by-calcium-phosphate-nanoparticles
#2
Olga Rotan, Katharina N Severin, Simon Pöpsel, Alexander Peetsch, Melisa Merdanovic, Michael Ehrmann, Matthias Epple
The efficient intracellular delivery of (bio)molecules into living cells remains a challenge in biomedicine. Many biomolecules and synthetic drugs are not able to cross the cell membrane, which is a problem if an intracellular mode of action is desired, for example, with a nuclear receptor. Calcium phosphate nanoparticles can serve as carriers for small and large biomolecules as well as for synthetic compounds. The nanoparticles were prepared and colloidally stabilized with either polyethyleneimine (PEI; cationic nanoparticles) or carboxymethyl cellulose (CMC; anionic nanoparticles) and loaded with defined amounts of the fluorescently labelled proteins HTRA1, HTRA2, and BSA...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28325295/aptamers-for-cd-antigens-from-cell-profiling-to-activity-modulation
#3
REVIEW
Amin Nozari, Maxim V Berezovski
Nucleic acid-based aptamers are considered to be a promising alternative to antibodies because of their strong and specific binding to diverse targets, fast and inexpensive chemical synthesis, and easy labeling with a fluorescent dye or therapeutic agent. Cluster of differentiation (CD) proteins are among the most popular antigens for aptamers on the cell surface. These anti-CD aptamers could be used in cell biology and biomedicine, from simple cell phenotyping by flow cytometry or fluorescent microscopy to diagnosis and treatment of HIV/AIDS to cancer and immune therapies...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28323441/breaking-binaries-biomedicine-and-serostatus-borderlands-among-couples-with-mixed-hiv-status
#4
Asha Persson, Christy E Newman, Jeanne Ellard
With recent breakthroughs in HIV treatment and prevention, the meanings of HIV-positivity and HIV-negativity are changing at biomedical and community levels. We explore how binary constructions of HIV serostatus identities are giving way to something more complex that brings both welcome possibilities and potential concerns. We draw on research with couples with mixed HIV status to argue that, in the context of lived experiences, serostatus identities have always been more ambiguous than allowed for in HIV discourse...
February 28, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28322394/self-assembly-of-magnesium-seamed-hexameric-pyrogallol-4-arene-nanocapsules
#5
Chen Zhang, Rahul S Patil, Tao Li, Charles L Barnes, Jerry L Atwood
The solvothermal synthesis of a metal-seamed hexameric nanocapsule from pyrogallol[4]arenes and magnesium is reported. The unique non-toxic and biocompatible nature of divalent magnesium cations in addition to the large inherent cavities make these nanocapsules promising for potential application in biomedicine. In addition, we show that these nanocapsules can form cocrystals with pyridine molecules through hydrogen bonding, which sheds light to cocrystallization of supramolecular nanocapsules with small pharmaceutics...
March 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28322268/universal-sensitivity-of-speckle-intensity-correlations-to-wavefront-change-in-light-diffusers
#6
KyungDuk Kim, Hyeonseung Yu, KyeoReh Lee, YongKeun Park
Here, we present a concept based on the realization that a complex medium can be used as a simple interferometer. Changes in the wavefront of an incident coherent beam can be retrieved by analyzing changes in speckle patterns when the beam passes through a light diffuser. We demonstrate that the spatial intensity correlations of the speckle patterns are independent of the light diffusers, and are solely determined by the phase changes of an incident beam. With numerical simulations using the random matrix theory, and an experimental pressure-driven wavefront-deforming setup using a microfluidic channel, we theoretically and experimentally confirm the universal sensitivity of speckle intensity correlations, which is attributed to the conservation of optical field correlation despite multiple light scattering...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322140/applications-and-risks-of-nanomaterials-used-in-regenerative-medicine-delivery-systems-theranostics-and-therapy
#7
Estefany I Medina-Reyes, Danae Garcia-Viacobo, Franklin A Carrero-Martinez, Yolanda Irasema Chirino
Recent advances in nanotechnology have transformed the biomedicine field, in which the use of engineered nanomaterials (ENMs) has provided the foundation for novel applications. For this reason, the number of ENMs has increased rapidly, and here we provide a classification of ENMs based on chemical composition and biomedical applications, which include regenerative medicine, delivery systems, theranostics, and therapy. These have been identified as the most advanced and promising areas for further studies with humans...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28317980/biodistribution-excretion-and-toxicity-of-polyethyleneimine-modified-nayf4-yb-er-upconversion-nanoparticles-in-mice-via-different-administration-routes
#8
Jie Yu, Wenyan Yin, Tao Peng, Ya-Nan Chang, Yan Zu, Juan Li, Xiao He, Xiaoyan Ma, Zhanjun Gu, Yuliang Zhao
Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we chose polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles (abbreviated as PEI@UCNPs) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation in the spleen within 30 days...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28317903/stability-and-dynamics-of-membrane-spanning-dna-nanopores
#9
Vishal Maingi, Jonathan R Burns, Jaakko J Uusitalo, Stefan Howorka, Siewert J Marrink, Mark S P Sansom
Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A fundamental question is how hydrophilic nanostructures reside in the hydrophobic environment of the membrane. Here, we use multiscale molecular dynamics (MD) simulations to explore the structure, stability and dynamics of an archetypical DNA nanotube inserted via a ring of membrane anchors into a phospholipid bilayer. Coarse-grained MD reveals that the lipids reorganize locally to interact closely with the membrane-spanning section of the DNA tube...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28315745/production-of-low-expressing-recombinant-cationic-biopolymers-with-high-purity
#10
Xuguang Chen, Alireza Nomani, Niket Patel, Arash Hatefi
The growing complexity of recombinant biopolymers for delivery of bioactive agents requires the ability to control the biomaterial structure with high degree of precision. Genetic engineering techniques have provided this opportunity to synthesize biomaterials in an organism such as E. coli with full control over their lengths and sequences. One class of such biopolymers is recombinant cationic biopolymers with applications in gene delivery, regenerative medicine and variety of other biomedical applications...
March 15, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28314652/corrigendum-to-hysteroscopy-prior-to-a-first-ivf-treatment-cycle-the-need-for-well-performed-rct-reproductive-biomedicine-online-29-2014-142-142
#11
Janine G Smit, Helen L Torrance, Frank Jm Broekmans, Ben-Willem Mol
No abstract text is available yet for this article.
March 14, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28314103/computational-study-of-the-forces-driving-aggregation-of-ultrasmall-nanoparticles-in-biological-fluids
#12
Sergio A Hassan
Nanoparticle (NP) aggregation can lead to prolonged retention in tissues or embolism, among other adverse effects. Successful use in biomedicine thus requires the capability to make NPs with limited aggregative potential. Rational design is presently a challenge due to incomplete knowledge of their interactions in biofluids. Recently, ultrasmall gold NPs passivated with endogenous antioxidant glutathione have shown promise for use in vivo. Computer simulations are here conducted to identify the forces underlying aggregation (or lack thereof) of these NPs in a cell culture...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28303951/enhancing-the-sensitivity-of-magnetic-sensors-by-3d-metamaterial-shells
#13
Carles Navau, Rosa Mach-Batlle, Albert Parra, Jordi Prat-Camps, Sergi Laut, Nuria Del-Valle, Alvaro Sanchez
Magnetic sensors are key elements in our interconnected smart society. Their sensitivity becomes essential for many applications in fields such as biomedicine, computer memories, geophysics, or space exploration. Here we present a universal way of increasing the sensitivity of magnetic sensors by surrounding them with a spherical metamaterial shell with specially designed anisotropic magnetic properties. We analytically demonstrate that the magnetic field in the sensing area is enhanced by our metamaterial shell by a known factor that depends on the shell radii ratio...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301003/minor-and-major-health-a-nietzschean-reading
#14
Emília Carvalho Leitão Biato, Luciano Bedin da Costa, Silas Borges Monteiro
This paper aims to discuss the concept of health, understood as multiple and plural. We use Friedrich Nietzsche's philosophical thought as an analytical tool, allowing us to reach a typology involving minor and major health. While the first is normative and sustained by an ideal of healing, the second is an expanding strength, a condition constantly achieved. If minor health follows a preset life moralization script, major health relates to the expanded living being, which affirms its creative nature and transcends established rules...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28299937/non-covalent-protein-and-peptide-functionalization-of-single-walled-carbon-nanotubes-for-bio-delivery-and-optical-sensing-applications
#15
Alessandra Antonucci, Justyna Kupis-Rozmyslowicz, Ardemis Boghossian
The exquisite structural and optical characteristics of single-walled carbon nanotubes (SWCNTs), combined with the tunable specificities of proteins and peptides, can be exploited to strongly benefit technologies with applications in fields ranging from biomedicine to industrial biocatalysis. The key to exploiting the synergism of these materials is designing protein/peptide-SWCNT conjugation schemes that preserve biomolecule activity while keeping the near-infrared optical and electronic properties of SWCNTs intact...
March 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28299394/caenorhabditis-elegans-as-a-powerful-alternative-model-organism-to-promote-research-in-genetic-toxicology-and-biomedicine
#16
REVIEW
Sebastian Honnen
In view of increased life expectancy the risk for disturbed integrity of genetic information increases. This inevitably holds the implication for higher incidence of age-related diseases leading to considerable cost increase in health care systems. To develop preventive strategies it is crucial to evaluate external and internal noxae as possible threats to our DNA. Especially the interplay of DNA damage response (DDR) and DNA repair (DR) mechanisms needs further deciphering. Moreover, there is a distinct need for alternative in vivo test systems for basic research and also risk assessment in toxicology...
March 15, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28293637/identification-of-candidate-genes-related-to-inflammatory-bowel-disease-using-minimum-redundancy-maximum-relevance-incremental-feature-selection-and-the-shortest-path-approach
#17
Fei Yuan, Yu-Hang Zhang, Xiang-Yin Kong, Yu-Dong Cai
Identification of disease genes is a hot topic in biomedicine and genomics. However, it is a challenging problem because of the complexity of diseases. Inflammatory bowel disease (IBD) is an idiopathic disease caused by a dysregulated immune response to host intestinal microflora. It has been proven to be associated with the development of intestinal malignancies. Although the specific pathological characteristics and genetic background of IBD have been partially revealed, it is still an overdetermined disease and the blueprint of all genetic variants still needs to be improved...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28292234/bovine-serum-albumin-as-a-versatile-platform-for-cancer-imaging-and-therapy
#18
Jun Wang, Bingbo Zhang
With the rapid development of nanotechnology, a large number of nanomaterials have been developed for cancer imaging and therapy. Among these nanomaterials, Bovine Serum Albumin (BSA) is attracting ever-increasing attention, due to biocompatibility, biodegradability, ease of availability and preparation, high drug loading efficiency and abundant number of functional groups. Currently, BSA-based nanoparticles are widely reported in the biomedical applications. This article reviews the applications of BSA as a versatile platform for cancer imaging and therapy, which includes BSA as drug carrier, surface modification agent and bio-mimetic template...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28289285/biomedicine-an-improved-gel-for-detached-retinas
#19
Stanley Chang
No abstract text is available yet for this article.
March 13, 2017: Nature
https://www.readbyqxmd.com/read/28287094/enlightening-discriminative-network-functional-modules-behind-principal-component-analysis-separation-in-differential-omic-science-studies
#20
Sara Ciucci, Yan Ge, Claudio Durán, Alessandra Palladini, Víctor Jiménez-Jiménez, Luisa María Martínez-Sánchez, Yuting Wang, Susanne Sales, Andrej Shevchenko, Steven W Poser, Maik Herbig, Oliver Otto, Andreas Androutsellis-Theotokis, Jochen Guck, Mathias J Gerl, Carlo Vittorio Cannistraci
Omic science is rapidly growing and one of the most employed techniques to explore differential patterns in omic datasets is principal component analysis (PCA). However, a method to enlighten the network of omic features that mostly contribute to the sample separation obtained by PCA is missing. An alternative is to build correlation networks between univariately-selected significant omic features, but this neglects the multivariate unsupervised feature compression responsible for the PCA sample segregation...
March 13, 2017: Scientific Reports
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