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https://www.readbyqxmd.com/read/28635377/how-are-we-applying-nanogel-composites-in-biomedicine
#1
Mrityunjoy Kar, Maria Molina, Marcelo Calderón
No abstract text is available yet for this article.
June 21, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28629096/synthesis-of-magnetic-nanoparticles-and-their-dispersions-with-special-reference-to-applications-in-biomedicine-and-biotechnology
#2
REVIEW
R V Mehta
Biomedical and biotechnological applications of magnetic nanoparticles and their dispersions in liquids are found to be potentially useful. An exponential growth in publications of papers, reviews and patents has been observed. Possibilities of their indiscriminate use on individual as well as environmental health hazards are also investigated. Still, there appears to be a good scope for further research work in the field. Even a small improvement either in preparation method or development of novel nanoparticles may prove to be beneficial in longer run...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629078/fluorescent-cds-pcl-hybrids-via-tartaric-acid-cds-cocatalyzed-polymerization
#3
Manqing Yan, Mingchen Zhou, Jing Chen, Tianlei Zhao, Longxiang Tang, Hong Bi
In this paper, the environment-friendly, water-soluble carbon dots (CDs) with stable photoluminescence (PL) have been prepared via the one-step pyrolysis of lotus leaf. Then the as-prepared CDs containing abundant hydroxylic and carboxylic groups were employed as cocatalyst with tartaric acid (TA) in ring-opening polymerization (ROP) of ε-caprolactone (ε-CL). The low-toxic organic acid TA, as main catalyst, was used to catalyze the ROP of ε-CL efficiently. The fluorescent CDs@PCL hybrids were obviously hydrophobic and they exhibited an excellent biocompatibility, and biodegradability due to the existence of PCL...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28623326/sialic-acid-linkage-differentiation-of-glycopeptides-using-capillary-electrophoresis-electrospray-ionization-mass-spectrometry
#4
Guinevere S M Kammeijer, Bas C Jansen, Isabelle Kohler, Anthonius A M Heemskerk, Oleg A Mayboroda, Paul J Hensbergen, Julie Schappler, Manfred Wuhrer
Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes. Due to very similar physico-chemical properties, the separation of isomeric sialylated glycopeptides remains challenging but of utmost importance in the biomedicine and biotechnology, including biomarker discovery, glyco-engineering and biopharmaceutical characterization. This study presents the implementation of a high-resolution separation platform based on capillary electrophoresis - mass spectrometry (CE-MS) allowing for the selective analysis of α2,3- and α2,6-sialylated glycopeptides...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621691/ovarian-preservation-improves-overall-survival-in-young-patients-with-early-stage-endometrial-cancer
#5
REVIEW
Peng Jia, Yan Zhang
We searched Medline, Embase, Cochrane library, the Chinese Biomedicine Literature Database, the Chinese Scientific Journal Full-text Database, the Chinese Journal Full-text Database, and the Wanfang Database to collect observational studies on the effects of ovary-saving surgery in comparison to bilateral salpingo-oophorectomy (BSO) in young patients with early-stage endometrial cancer (EC). The literature search included studies up to March 2017, and 10 retrospective cohort studies met our selection criteria...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28618993/new-perspectives-on-biomedical-applications-of-iron-oxide-nanoparticles
#6
Massimiliano Magro, Davide Baratella, Emanuela Bonaiuto, Jessica de Almeida Roger, Fabio Vianello
Iron oxide nanomaterials are considered promising tools for improved therapeutic efficacy and diagnostic applications in biomedicine. Accordingly, engineered iron oxide nanomaterials are increasingly proposed in biomedicine, and the interdisciplinary researches involving physics, chemistry, biology (nanotechnology) and medicine have led to exciting developments in the last decades. The progresses of the development of magnetic nanoparticles with tailored physico-chemical and surface properties produced a variety of clinically relevant applications, spanning from magnetic resonance imaging (MRI), drug delivery, magnetic hyperthermia, to in vitro diagnostics...
June 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28616986/on-a-chip-biosensing-based-on-all-dielectric-nanoresonators
#7
Ozlem Yavas, Mikael Svedendahl, Paulina Dobosz, Vanesa Sanz, Romain Quidant
Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the nanometer scale has widely contributed to biosensing and enhanced spectroscopy. Recently, high-refractive index dielectric nanostructures featuring low loss resonances have been proposed as a promising alternative to nanoplasmonics, potentially offering better sensing performances along with full compatibility with the microelectronics industry...
June 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28616689/the-reality-of-scientific-research-in-latin-america-an-insider-s-perspective
#8
Daniel R Ciocca, Gabriela Delgado
There is tremendous disparity in scientific productivity among nations, particularly so in Latin America. At first sight, this could be linked to the relative economic health of the different countries of the region, but even large and relatively rich Latin American countries do not produce a good level of science. Although Latin America has increased the number of its scientists and research institutions in recent years, the gap between developed countries and Latin American countries is startling. The prime importance of science and technology to the development of a nation remains unacknowledged...
June 14, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28615635/dna-backbone-sulfur-modification-expands-microbial-growth-range-under-multiple-stresses-by-its-anti-oxidation-function
#9
Yan Yang, Guanpeng Xu, Jingdan Liang, Ying He, Lei Xiong, Hui Li, Douglas Bartlett, Zixin Deng, Zhijun Wang, Xiang Xiao
DNA phosphorothioate (PT) modification is a sulfur modification on the backbone of DNA introduced by the proteins DndA-E. It has been detected within many bacteria isolates and metagenomic datasets, including human pathogens, and is considered to be widely distributed in nature. However, little is known about the physiological function of this modification, and thus its evolutionary significance and application potential remains largely a mystery. In this study, we focused on the advantages of DNA PT modification to bacterial cells coping with environmental stresses...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613180/atomic-force-microscopy-in-characterizing-cell-mechanics-for-biomedical-applications-a-review
#10
Mi Li, Dan Dang, Lianqing Liu, Ning Xi, Yuechao Wang
Cell mechanics is a novel label-free biomarker for indicating cell states and pathological changes. The advent of atomic force microscopy (AFM) provides a powerful tool for quantifying the mechanical properties of single living cells in aqueous conditions. The wide use of AFM in characterizing cell mechanics in the past two decades have yielded remarkable novel insights in understanding the development and progression of certain diseases such as cancer, showing the huge potential of cell mechanics for practical applications in the field of biomedicine...
June 9, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28612711/alleviative-effects-from-boswellic-acid-on-acetaminophen-induced-hepatic-injury-corrected-and-republished-from-biomedicine-taipei-2016-jun-6-2-9-doi-10-7603-s40681-016-0009-1pmcid-pmc4864770
#11
Lung-Che Chen, Li-Hong Hu, Mei-Chin Yin
Protective effects of boswellic acid (BA) against acetaminophen (APAP)-induced hepatotoxicity in Balb/ cA mice were examined. BA, at 0.05 or 0.1%, was supplied for 4 weeks. Acute liver injury was induced by APAP treatment. Results showed that BA intake increased hepatic BA bioavailability. APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase (HO)-1 in liver...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28605120/emerging-0d-transition-metal-dichalcogenides-for-sensors-biomedicine-and-clean-energy
#12
REVIEW
Bang Lin Li, Magdiel Inggrid Setyawati, Hao Lin Zou, Jiang Xue Dong, Hong Qun Luo, Nian Bing Li, David Tai Leong
Following research on two-dimensional (2D) transition metal dichalcogenides (TMDs), zero-dimensional (0D) TMDs nanostructures have also garnered some attention due to their unique properties; exploitable for new applications. The 0D TMDs nanostructures stand distinct from their larger 2D TMDs cousins in terms of their general structure and properties. 0D TMDs possess higher bandgaps, ultra-small sizes, high surface-to-volume ratios with more active edge sites per unit mass. So far, reported 0D TMDs can be mainly classified as quantum dots, nanodots, nanoparticles, and small nanoflakes...
June 12, 2017: Small
https://www.readbyqxmd.com/read/28604617/targeted-magnetic-nanotheranostics-of-cancer
#13
REVIEW
Irina Belyanina, Olga Kolovskaya, Sergey Zamay, Ana Gargaun, Tatiana Zamay, Anna Kichkailo
Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes...
June 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28604245/state-of-the-art-or-the-art-of-medicine-transnational-mobility-and-perceptions-of-multiple-biomedicines-among-nigerian-physicians-in-the-u-s
#14
Judith Schühle
Over the last 40 years, several thousand Nigerian-trained doctors have migrated to the U.S. to practice in what they regard as the state-of-the-art of global biomedicine. Based on interviews with Nigerian physicians, this article shows how their professional mobility, and their transition to the new professional environment of U.S. biomedicine, makes them aware of local differences in practicing medicine. Adapting to local ways of practicing in the U.S. creates a new sense of belonging and professional identity...
June 12, 2017: Global Public Health
https://www.readbyqxmd.com/read/28601759/cell-compatible-conducting-polyaniline-films-prepared-in-colloidal-dispersion-mode
#15
Věra Kašpárková, Petr Humpolíček, Zdenka Capáková, Patrycja Bober, Jaroslav Stejskal, Miroslava Trchová, Petra Rejmontová, Ita Junkar, Marián Lehocký, Miran Mozetič
Conducting polyaniline can be prepared and modified using several procedures, all of which can significantly influence its applicability in different fields of biomedicine or biotechnology. The modifications of surface properties are crucial with respect to the possible applications of this polymer in tissue engineering or as biosensors. Innovative technique for preparing polyaniline films via in-situ polymerization in colloidal dispersion mode using four stabilizers (poly-N-vinylpyrrolidone; sodium dodecylsulfate; Tween 20 and Pluronic F108) was developed...
May 31, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28601650/tough-chitosan-hydrogel-based-on-purified-regeneration-and-alkaline-solvent-as-biomaterials-for-tissue-engineering-applications
#16
Shichao Bi, Zixian Bao, Xiaoyu Bai, Shihao Hu, Xiaojie Cheng, Xiguang Chen
The chitosan based on purified regeneration could be dissolved in 6wt% aqueous NaOH without freeze-thawing cycles and acetylation processing, and such a solution system was effective and different from other dissolving methods Upon heating, a tough hydrogel was constructed from the chitosan (purified regeneration) alkaline solution. The results of XRD, TEM, SEM and rheology analysis proved that chitosan easily aggregated in the solution and formed a nanofibers network to gelate at elevated temperature and concentration...
June 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28596588/optimization-of-a-crispr-cas9-mediated-knock-in-strategy-at-the-porcine-rosa26-locus-in-porcine-foetal-fibroblasts
#17
Zicong Xie, Daxin Pang, Kankan Wang, Mengjing Li, Nannan Guo, Hongming Yuan, Jianing Li, Xiaodong Zou, Huping Jiao, Hongsheng Ouyang, Zhanjun Li, Xiaochun Tang
Genetically modified pigs have important roles in agriculture and biomedicine. However, genome-specific knock-in techniques in pigs are still in their infancy and optimal strategies have not been extensively investigated. In this study, we performed electroporation to introduce a targeting donor vector (a non-linearized vector that did not contain a promoter or selectable marker) into Porcine Foetal Fibroblasts (PFFs) along with a CRISPR/Cas9 vector. After optimization, the efficiency of the EGFP site-specific knock-in could reach up to 29...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596363/polymeric-peptide-pigments-with-sequence-encoded-properties
#18
Ayala Lampel, Scott A McPhee, Hang-Ah Park, Gary G Scott, Sunita Humagain, Doeke R Hekstra, Barney Yoo, Pim W J M Frederix, Tai-De Li, Rinat R Abzalimov, Steven G Greenbaum, Tell Tuttle, Chunhua Hu, Christopher J Bettinger, Rein V Ulijn
Melanins are a family of heterogeneous polymeric pigments that provide ultraviolet (UV) light protection, structural support, coloration, and free radical scavenging. Formed by oxidative oligomerization of catecholic small molecules, the physical properties of melanins are influenced by covalent and noncovalent disorder. We report the use of tyrosine-containing tripeptides as tunable precursors for polymeric pigments. In these structures, phenols are presented in a (supra-)molecular context dictated by the positions of the amino acids in the peptide sequence...
June 9, 2017: Science
https://www.readbyqxmd.com/read/28595759/what-is-healing-reflections-on-diagnostic-criteria-nosology-and-etiology
#19
Jeff Levin
This article examines the conceptual history and contemporary usages of the term "healing." In response to longstanding definitional ambiguity, reflections are offered on what are termed the diagnostic criteria, nosology, and etiology of healing. First, a summary is provided of how healing has been defined within medicine. Second, the dimensionality of healing is discussed. Third, healing's putative determinants are outlined. For biomedicine, healing mainly concerns repair of wounds or lesions and is unidimensional...
May 11, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28594475/what-is-safety-miracles-benefit-risk-assessments-and-the-right-to-try
#20
Lisa M DeTora
Public discourse is full of quick solutions to health care problems like cancer and rare diseases. Among these is Right to Try legislation for experimental therapies. Right to Try legislation is based on the premise that all experimental agents in clinical trials are safe and guaranteed to produce miracles. Unfortunately, this notion is at odds with expert understanding, which indicates that the benefits and risks of drug products can only be understood together and evaluated incrementally and over time. The current manuscript examines why benefit to risk considerations, a lynchpin of the ethical conduct of clinical research since the Nuremberg Code, might be easily elided from public discourse...
June 8, 2017: International Journal of Clinical Practice
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