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https://www.readbyqxmd.com/read/28432776/exploring-non-obvious-hydrophobic-binding-pockets-on-protein-surfaces-increasing-affinities-in-peptide-protein-interactions
#1
Lars Baltzer, Aleksandra Balliu
A 42-residue polypeptide conjugated to a small organic molecule capable of targeting the phosphorylated side chain of Ser-15 was shown to bind glycogen phosphorylase a (GPa) with a KD of 280 nM. The replacement of hydrophobic amino acids by Ala reduced affinities, whereas the incorporation of L-2-aminooctanoic acid (Aoc) increased affinities. Replacing Nle-5, Ile-9 and Leu-12 by Aoc reduced the KD from 280 nM to 27 nM. Downsizing the 42-mer to an 11-mer gave rise to an order of magnitude lower affinity for GPa but the 11-mer where Nle-5, Ile-9 and Leu-12 were replaced by Aoc showed a KD of 550 nM, comparable to that of the parent 42-mer...
April 22, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28431482/nanozyme-applications-in-biology-and-medicine-an-overview
#2
Jafar Golchin, Kazem Golchin, Neda Alidadian, Shahrooz Ghaderi, Sajjad Eslamkhah, Masoud Eslamkhah, Abolfazl Akbarzadeh
Nanozymes, in nature, are artificial enzymes. Innovated by Ronald Breslow to mimic enzymes. Nanozymes have widespread applications including targeted cancer therapy, diagnostic medicine and bio-sensing even environmental toxicology. However, these applications are a novel research field in biomedicine, but are growing fast. Enzyme-based applications such as immune-absorbent assay (ELIZA) are expensive because of the complexity of producing enzymes and antibodies. Not only, some nanoparticles can mimic these enzymes such as superoxides, but also they can manipulate biological pathways directly like autophagy...
April 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28430873/bioinformatics-in-germany-toward-a-national-level-infrastructure
#3
Andreas Tauch, Arwa Al-Dilaimi
The German Network for Bioinformatics Infrastructure (de.NBI) is a national initiative funded by the German Federal Ministry of Education and Research (BMBF). The mission of de.NBI is (i) to provide high-quality bioinformatics services to users in basic and applied life sciences research from academia, industry and biomedicine; (ii) to offer bioinformatics training to users in Germany and Europe through a wide range of workshops and courses; and (iii) to foster the cooperation of the German bioinformatics community with international network structures such as the European life-sciences Infrastructure for biological Information (ELIXIR)...
April 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28430254/lensless-wide-field-single-shot-imaging-through-turbid-media-based-on-object-modulated-speckles
#4
Pengfei Wu, Zi Liang, Xing Zhao, Lei Su, Lipei Song
The need to image objects through light-scattering materials is common in a range of applications. Different methods have been investigated to acquire the image of the object when diffusers are presented. In this paper, we demonstrate the object reconstruction with single-shot imaging based on the correlography principle and phase retrieval algorithm with coherent illumination. We prove the possibility of reconstructing positive and negative objects in both transmission and reflection modes with collimated and scattered light...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28429567/the-tsimane-health-and-life-history-project-integrating-anthropology-and-biomedicine
#5
Michael Gurven, Jonathan Stieglitz, Benjamin Trumble, Aaron D Blackwell, Bret Beheim, Helen Davis, Paul Hooper, Hillard Kaplan
The Tsimane Health and Life History Project, an integrated bio-behavioral study of the human life course, is designed to test competing hypotheses of human life-history evolution. One aim is to understand the bidirectional connections between life history and social behavior in a high-fertility, kin-based context lacking amenities of modern urban life (e.g. sanitation, banks, electricity). Another aim is to understand how a high pathogen burden influences health and well-being during development and adulthood...
April 2017: Evolutionary Anthropology
https://www.readbyqxmd.com/read/28426068/amplification-of-the-molecular-chiroptical-effect-by-low-loss-dielectric-nanoantennas
#6
Weixuan Zhang, Tong Wu, Rongyao Wang, Xiangdong Zhang
We report here the chiroptical amplification effect occurring in the hybrid systems consisting of chiral molecules and Si nanostructures. Under resonant excitation of circularly polarized light, the hybrid systems show strong CD induction signals at the optical frequency, which arise from both the electric and magnetic responses of the Si nanostructures. More interestingly, the induced CD signals from Si-based dielectric nanoantennas are always larger than that from Au-based plasmonic counterparts. The related physical origin was disclosed...
April 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28425519/electrolytic-conductivity-related-radiofrequency-heating-of-aqueous-suspensions-of-nanoparticles-for-biomedicine
#7
Konstantin Tamarov, Maxim Gongalsky, Liubov Osminkina, Yuanhui Huang, Murad Omar, Valery Yakunin, Vasilis Ntziachristos, Daniel Razansky, Victor Timoshenko
The development of suitable contrast agents can significantly enhance the efficiency of modern imaging and treatment techniques, such as thermoacoustic (TA) tomography and radio-frequency (RF) hyperthermia of cancer. Here, we examine the heating of aqueous suspensions of silicon (Si) and gold (Au) nanoparticles (NPs) under RF irradiation in the MHz frequency range. The heating rate of aqueous suspensions of Si NPs exhibited non-monotonic dependency on the electrical conductivity of the suspension. The experimental results were explained by the mathematical model considering oscillating solvated ions as the main source of Joule heating...
April 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28425189/the-global-ethics-corner-foundations-beliefs-and-the-teaching-of-biomedical-and-scientific-ethics-around-the-world
#8
Henry Jakubowski, Jianping Xie, Arup Kumar Mitra, Ravindra Ghooi, Saman Hosseinkhani, Mohsen Alipour, Behnam Hajipour, George Obiero
The profound advances in the biomolecular sciences over the last decades have enabled similar advances in biomedicine. These advances have increasingly challenged our abilities to deploy them in an equitable and ethically acceptable manner. As such, it has become necessary and important to teach biomedical and scientific ethics to our students who will become the researchers, medical professionals, and global citizens of the future. As advances in the biosciences and medicine are made, developed, and used across the globe, our survival on an endangered planet requires global dialog and consensual action...
April 19, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28425044/systematic-review-for-geo-authentic-lonicerae-japonicae-flos
#9
REVIEW
Xingyue Yang, Yali Liu, Aijuan Hou, Yang Yang, Xin Tian, Liyun He
In traditional Chinese medicine, Lonicerae Japonicae Flos is commonly used as anti-inflammatory, antiviral, and antipyretic herbal medicine, and geo-authentic herbs are believed to present the highest quality among all samples from different regions. To discuss the current situation and trend of geo-authentic Lonicerae Japonicae Flos, we searched Chinese Biomedicine Literature Database, Chinese Journal Full-text Database, Chinese Scientific Journal Full-text Database, Cochrane Central Register of Controlled Trials, Wanfang, and PubMed...
April 19, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28423831/the-biotop-family-of-upper-level-ontological-resources-for-biomedicine
#10
Stefan Schulz, Martin Boeker, Catalina Martinez-Costa
BioTop is a domain upper level ontology for the life sciences, based on OWL DL, introduced ten years ago. This paper provides an update of the current state of this resource, with a special focus on BioTop's top level, BioTopLite, which currently contains 55 classes, 37 object properties and 247 description logics axioms. A bridging file allows harmonising BioTopLite with the classes of Basic Formal Ontology BFO2. The updated OWL resources are available at http://purl.org/biotop. They build the core of several upper level ontological artefacts including bridging ontologies to other upper level resources...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423769/linked-data-applications-through-ontology-based-data-access-in-clinical-research
#11
Ann-Kristin Kock-Schoppenhauer, Christian Kamann, Hannes Ulrich, Petra Duhm-Harbeck, Josef Ingenerf
Clinical care and research data are widely dispersed in isolated systems based on heterogeneous data models. Biomedicine predominantly makes use of connected datasets based on the Semantic Web paradigm. Initiatives like Bio2RDF created Resource Description Framework (RDF) versions of Omics resources, enabling sophisticated Linked Data applications. In contrast, electronic healthcare records (EHR) data are generated and processed in diverse clinical subsystems within hospital information systems (HIS). Usually, each of them utilizes a relational database system with a different proprietary schema...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28422984/the-impact-of-atosiban-on-pregnancy-outcomes-in-women-undergoing-in-vitro-fertilization-embryo-transfer-a-meta-analysis
#12
Qian-Yi Huang, Min-Hua Rong, Ai-Hua Lan, Xiao-Miao Lin, Xing-Gu Lin, Rong-Quan He, Gang Chen, Mu-Jun Li
BACKGROUND: Atosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF). METHODS: Databases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF...
2017: PloS One
https://www.readbyqxmd.com/read/28422486/stable-nanocomposite-based-on-pegylated-and-silver-nanoparticles-loaded-graphene-oxide-for-long-term-antibacterial-activity
#13
Rongtao Zhao, Min Lv, Yang Li, Mingxuan Sun, Wen Kong, Lihua Wang, Shiping Song, Chunhai Fan, Leili Jia, Shaofu Qiu, Yansong Sun, Hongbin Song, Rongzhang Hao
The increasing occurrence of antibiotic-resistant pathogens, especially superbugs, is compromising the efficacy of traditional antibiotics. Silver nanoparticles (AgNPs) loaded graphene oxide (GO) nanocomposite (GO-Ag) has drawn great interest as a promising alternative antibacterial material. However, GO-Ag nanocomposite often irreversibly aggregates in physiological solutions, severely influencing its antibacterial capacity and practical application. Herein, a PEGylated and AgNPs loaded GO nanocomposite (GO-PEG-Ag) is synthesized through a facile approach utilizing microwave irradiation, while avoiding extra reducing agents...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28421497/chapter-13-human-ovarian-tissue-vitrification
#14
Sherman Silber
Ovarian freezing and transplantation has garnered increasing interest as a potential way of preserving fertility in cancer patients as well as for women who just wish to delay childbearing. This chapter spells out our techniques of ovarian cortex vitrification and results for frozen compared to fresh ovarian cortex transplantation (in one single series from one center for the sake of consistency), as well as potentially provides insight into the mechanism behind ovarian follicle recruitment. This represents an effort to simplify and popularize an approach that has yielded favorable results (all cases recovered ovulation and 75% had successful spontaneous pregnancy) in one single, disciplined study...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28420078/natural-phenol-polymers-recent-advances-in-food-and-health-applications
#15
REVIEW
Lucia Panzella, Alessandra Napolitano
Natural phenol polymers are widely represented in nature and include a variety of classes including tannins and lignins as the most prominent. Largely consumed foods are rich sources of phenol polymers, notably black foods traditionally used in East Asia, but other non-edible, easily accessible sources, e.g., seaweeds and wood, have been considered with increasing interest together with waste materials from agro-based industries, primarily grape pomace and other byproducts of fruit and coffee processing. Not in all cases were the main structural components of these materials identified because of their highly heterogeneous nature...
April 14, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28419915/enhanced-imaging-of-lipid-rich-nanoparticles-embedded-in-methylcellulose-films-for-transmission-electron-microscopy-using-mixtures-of-heavy-metals
#16
Jalal Asadi, Sophie Ferguson, Hussain Raja, Christian Hacker, Phedra Marius, Richard Ward, Christos Pliotas, James Naismith, John Lucocq
Synthetic and naturally occurring lipid-rich nanoparticles are of wide ranging importance in biomedicine. They include liposomes, bicelles, nanodiscs, exosomes and virus particles. The quantitative study of these particles requires methods for high-resolution visualization of the whole population. One powerful imaging method is cryo-EM of vitrified samples, but this is technically demanding, requires specialized equipment, provides low contrast and does not reveal all particles present in a population. Another approach is classical negative stain-EM, which is more accessible but is difficult to standardize for larger lipidic structures, which are prone to artifacts of structure collapse and contrast variability...
April 10, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28417067/quantitative-photoacoustic-integrating-sphere-qpais-platform-for-absorption-coefficient-and-gr%C3%A3-neisen-parameter-measurements-demonstration-with-human-blood
#17
Yolanda Villanueva-Palero, Erwin Hondebrink, Wilma Petersen, Wiendelt Steenbergen
Quantitative photoacoustic imaging in biomedicine relies on accurate measurements of relevant material properties of target absorbers. Here, we present a method for simultaneous measurements of the absorption coefficient and Grüneisen parameter of small volume of liquid scattering and absorbing media using a coupled-integrating sphere system which we refer to as quantitative photoacoustic integrating sphere (QPAIS) platform. The derived equations do not require absolute magnitudes of optical energy and pressure values, only calibration of the setup using aqueous ink dilutions is necessary...
June 2017: Photoacoustics
https://www.readbyqxmd.com/read/28415521/effect-of-halloysite-nanotubes-on-the-structure-and-function-of-important-multiple-blood-components
#18
Keke Wu, Ru Feng, Yanpeng Jiao, Changren Zhou
Many researchers have investigated the application of halloysite nanotubes (HNTs) in biomedicine, because of their special nanoscale hollow tubular structure. Although the cytocompatibility of HNTs has been studied, their blood compatibility has not been systematically investigated. In this work, the effect of HNTs on the structure and function of different blood components has been studied, including the morphology and hemolysis of red blood cells (RBCs). Based on scanning electron microscopy (SEM) observations, optical density test and flow cytometry analysis, we found that HNTs can affect the morphology and membrane integrity of RBCs in phosphate buffered saline (PBS) in a content-dependent way...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415382/alkali-etching-growth-of-nest-like-ag-mtio2-hierarchical-nanostructures-and-their-potential-applications
#19
Zongnan Zhang, Haijiao Zhang
Porous nanomaterials have attracted extensive interests in adsorption, catalysis, biosensors, and biomedicine due to their high surface area, well-defined pore structure and tunable pore size. However, how to obtain porous nanomaterials of desirable component and unique structure with multifunctionalities and synergetic properties is still a great challenge. In this work, a novel nest-like Ag@mTiO2 hierarchical nanostructure with Ag nanoparticle as the core and a mesoporous crystalline TiO2 as the protective shell was successfully prepared by layer-by-layer assembly technique and alkali-etching hydrothermal route...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414735/the-coexistence-of-traditional-medicine-and-biomedicine-a-study-with-local-health-experts-in-two-brazilian-regions
#20
Sofia Zank, Natalia Hanazaki
This study investigated the combined use of traditional medicine and biomedicine by local experts in Chapada do Araripe communities (Ceará State) and maroon communities (Santa Catarina State), Brazil. The objective was to understand the perception of local health specialists regarding the number of healers, demand for healers and use of medicinal plants, and the dependence of different environments to obtain such plants. We also aimed to understand the role of medicinal plants to treat different categories of diseases and if there is a complementary use of medicinal plants and allopathic biomedicine, according to the context of each group...
2017: PloS One
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