keyword
https://read.qxmd.com/read/38536043/unlocking-diverse-%C3%AF-bond-enrichment-frameworks-by-the-synthesis-and-conversion-of-boronated-phenyldiethynylethylenes
#1
JOURNAL ARTICLE
Jinhui Xie, Wangyang Li, Yong Lu, Yanping Zheng, Yanying Huang, Shanglin Chen, Qiuling Song
The π-bond enrichment frameworks not only serve as a crucial building block in organic synthesis but also assume a pivotal role in the fields of materials science, biomedicine, photochemistry, and other related disciplines owing to their distinctive structural characteristics. The incorporation of various substituents into the C═C double bonds of tetrasubstituted alkenes is currently a highly significant research area. However, the synthesis of tetrasubstituted alkenes with diverse substituents on double bonds poses a significant challenge in achieving stereoselectivity...
March 27, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38535700/biosynthesis-of-cu-in-s-nanoparticles-by-a-yeast-isolated-from-union-glacier-antarctica-a-platform-for-enhanced-quantum-dot-sensitized-solar-cells
#2
JOURNAL ARTICLE
Carolina Arriaza-Echanes, Jessica L Campo-Giraldo, Felipe Valenzuela-Ibaceta, Javiera Ramos-Zúñiga, José M Pérez-Donoso
In recent years, the utilization of extremophile microorganisms for the synthesis of metal nanoparticles, featuring enhanced properties and diverse compositions, has emerged as a sustainable strategy to generate high-quality nanomaterials with unique characteristics. Our study focuses on the biosynthesis of Cu-In-S (CIS) nanoparticles, which has garnered considerable attention in the past decade due to their low toxicity and versatile applications in biomedicine and solar cells. Despite this interest, there is a notable absence of reports on biological methods for CIS nanoparticle synthesis...
March 21, 2024: Nanomaterials
https://read.qxmd.com/read/38535689/cobalt-ferrite-nanorods-synthesized-with-a-facile-green-method-in-a-magnetic-field
#3
JOURNAL ARTICLE
Alexander L Kwiatkowski, Petr V Shvets, Ivan S Timchenko, Darya E Kessel, Elizaveta D Shipkova, Konstantin I Maslakov, Ivan A Kuznetsov, Dmitry A Muravlev, Olga E Philippova, Andrey V Shibaev
We report a new facile method for the synthesis of prolate cobalt ferrite nanoparticles without additional stabilizers, which involves a co-precipitation reaction of Fe3+ and Co2+ ions in a static magnetic field. The magnetic field is demonstrated to be a key factor for the 1D growth of cobalt ferrite nanocrystals in the synthesis. Transmission electron microscopy (TEM), X-ray diffraction (XRD), and Raman spectroscopy are applied to characterize the morphology and structure of the obtained nanoparticles. According to TEM, they represent nanorods with a mean length of 25 nm and a diameter of 3...
March 20, 2024: Nanomaterials
https://read.qxmd.com/read/38535272/advancements-in-biomedical-applications-of-calcium-phosphate-glass-and-glass-based-devices-a-review
#4
REVIEW
Jawad T Pandayil, Nadia G Boetti, Davide Janner
Calcium phosphate (CaP) glass has recently gained popularity as a promising material for a wide range of biomedical applications. Recent developments have seen CaP glasses moving from a passive implant material to an active degradable material, particularly as a major constituent of bioresorbable photonic devices. This holds great promise in advanced biomedical applications, since the main constituents of CaP glasses are present in the human body. In this review, the progressive advancements in the biomedical applications of calcium phosphate glass-based devices over the past 50 years are discussed...
March 21, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534224/bimetallic-coordination-polymers-synthesis-and-applications-in-biosensing-and-biomedicine
#5
REVIEW
Yanping Sun, Jianxin Ma, Faisal Ahmad, Yelan Xiao, Jingyang Guan, Tong Shu, Xueji Zhang
Bimetallic coordination polymers (CPs) have two different metal ions as connecting nodes in their polymer structure. The synthesis methods of bimetallic CPs are mainly categorized into the one-pot method and post-synthesis modifications according to various needs. Compared with monometallic CPs, bimetallic CPs have synergistic effects and excellent properties, such as higher gas adsorption rate, more efficient catalytic properties, stronger luminescent properties, and more stable loading platforms, which have been widely applied in the fields of gas adsorption, catalysis, energy storage as well as conversion, and biosensing...
February 22, 2024: Biosensors
https://read.qxmd.com/read/38533973/50-nm-gas-filled-protein-nanostructures-to-enable-the-access-of-lymphatic-cells-by-ultrasound-technologies
#6
JOURNAL ARTICLE
Qionghua Shen, Zongru Li, Yixian Wang, Matthew D Meyer, Marc T De Guzman, Janie C Lim, Han Xiao, Richard R Bouchard, George J Lu
Ultrasound imaging and ultrasound-mediated gene and drug delivery are rapidly advancing diagnostic and therapeutic methods; however, their use is often limited by the need of microbubbles, which cannot transverse many biological barriers due to their large size. Here we introduce 50-nm gas-filled protein nanostructures derived from genetically engineered gas vesicles that we referred to as 50nm GVs. These diamond-shaped nanostructures have hydrodynamic diameters smaller than commercially available 50-nm gold nanoparticles and are, to our knowledge, the smallest stable, free-floating bubbles made to date...
March 27, 2024: Advanced Materials
https://read.qxmd.com/read/38533593/evaluation-of-the-performance-of-a-7-t-8%C3%A2-%C3%A3-%C3%A2-2-transceiver-array
#7
JOURNAL ARTICLE
Junghwan Kim, Changyu Sun, Chan Hong Moon, Hoby Hetherington, Jullie Pan
The decoupled 8 × 2 transceiver array has been shown to achieve a mean B1 + of 11.7 uT with a coefficient of variation of ~11% over the intracranial brain volume for 7-T MR imaging. However, this array may be thought to give lower signal-to-noise ratio (SNR) and higher g-factors for parallel imaging compared with a radio frequency (RF) receive-only coil due to the latter's higher coil count and use of coil overlap to reduce the mutual impedance. Nonetheless, because the transceiver's highly decoupled design (pertinent for transmission) should also be constructive for reception, we measured the noise correlation, g-factors, and SNR for the decoupled transceiver in comparison with a commercial reference coil...
March 27, 2024: NMR in Biomedicine
https://read.qxmd.com/read/38533302/biomedicines-in-longevity-and-aging-the-quest-to-resist-biological-decline
#8
REVIEW
Raymond D Palmer
Aging is considered part of the natural process of life, however in recent years medical literature has started to show that specific facets of aging are beginning to be understood and those factors may even be considered preventable with various measures. Aging is also considered the number one cause of poor quality of life, disease, disability, and death, so the importance of understanding the aging process and how to control certain aspects of it cannot be underestimated when age related suffering is factored in...
2024: BioMedicine
https://read.qxmd.com/read/38533301/impact-and-prevalence-of-comorbidities-and-complications-on-the-severity-of-covid-19-in-association-with-age-gender-obesity-and-pre-existing-smoking-a-meta-analysis
#9
REVIEW
Soulandi Djorwé, Amale Bousfiha, Néhémie Nzoyikorera, Joseph Nyandwi, Bellamine Kawthar, Abderrahim Malki
BACKGROUND: COVID-19 patients usually present multiple comorbidities and complications associated with severe forms of SARS-CoV-2 infection. This study aimed to assess the risk factors and prevalence of comorbidities and complications contributing to the severity of COVID-19. METHODS: This meta-analysis was performed according to PRISMA guidelines. We searched various databases, including PubMed, Google Scholar, and Scopus (between 2020 and 2023), for eligible studies for this meta-analysis...
2024: BioMedicine
https://read.qxmd.com/read/38533300/a-brief-literature-review-of-low-level-laser-therapy-for-treating-amyotrophic-lateral-sclerosis-and-confirmation-of-its-effectiveness
#10
REVIEW
Sergey V Moskvin
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a steadily progressive course due to the death of central and peripheral motor neurons responsible for voluntary movements. Low-level laser therapy (LLLT) is a treatment method unique in its universality and efficacy, particularly for neurodegenerative diseases. METHODS: In this review, we discuss the effect and application of LLLT in the treatment of ALS. A literature search for English and Russian publications for the keywords "Amyotrophic Lateral Sclerosis", "Low-Level Laser Therapy" was performed using PubMed, Scopus, Google Scholar, Web of Science and Russian Science Citation Index (RSCI) databases...
2024: BioMedicine
https://read.qxmd.com/read/38533299/vkorc1-polymorphisms-and-complete-resistance-to-vitamin-k-antagonists-about-two-cases
#11
Ilham Benyamna, Houda El Fissi, Fadoua Bouzid, Abdelhamid El Mousadik, Najat Alif
Complete resistance to vitamin K antagonists is a rare but serious condition. It can complicate therapeutic management, especially when direct oral anticoagulants cannot be used. Some single mutations in the VKORC1 gene have been identified in patients partially or completely resistant to vitamin K antagonists. We report the cases of two women in their fifties who presented an unexplained peripheral venous thrombosis. The aetiological assessment did not show any abnormalities. Genetic testing showed that both patients had the VKORC1 5417 GG genotype...
2024: BioMedicine
https://read.qxmd.com/read/38533298/computational-analysis-of-dimer-g6pd-structure-to-elucidate-pathogenicity-of-g6pd-variants
#12
JOURNAL ARTICLE
Shamini Chandran, Naveen Eugene Louis, Syazwani Itri Amran, Nurriza Ab Latif, Muaawia Ahmed Hamza, Mona Alonazi
An inherent genetic enzyme disorder in humans, known as glucose-6-phosphate dehydrogenase (G6PD) deficiency, arises due to specific mutations. While the prevailing approach for investigating G6PD variants involves biochemical analysis, the intricate structural details remain limited, impeding a comprehensive understanding of how different G6PD variants of varying classes impact their functionality. This study 22 examined the dynamic properties of G6PD wild types and six G6PD variants from 23 different classes using molecular dynamic simulation (MDS)...
2024: BioMedicine
https://read.qxmd.com/read/38533297/ethanol-leaf-extracts-of-anogeissus-leiocarpus-in-antioxidants-and-hepatotoxic-effects-of-escherichia-coli-o157-h7-infected-swiss-mice
#13
JOURNAL ARTICLE
Fred C Akharaiyi, Chioma B Ehis-Eriakha, Peter T Olagbemide, Stephen E Akemu
INTRODUCTION: Diseases caused by bacteria can be managed with medicinal plants with rightful dosage that will not affect body physiology and organs. AIM: This research aimed to evaluate the antioxidants and the effects of Anogeisus leiocarpus on liver function. MATERIALS AND METHODS: Ethanol leaf extracts were processed for antioxidants and hepatotoxic effects using animal models. Group one (negative control) was given access to water and regular feed, group two (positive control) was dosed with 107 CFU/ml of Escherichia coli O157:H7, and groups 3-6 were dosed with 107 E ...
2024: BioMedicine
https://read.qxmd.com/read/38532082/three-dimensional-reconstruction-of-industrial-parts-from-a-single-image
#14
JOURNAL ARTICLE
Zhenxing Xu, Aizeng Wang, Fei Hou, Gang Zhao
This study proposes an image-based three-dimensional (3D) vector reconstruction of industrial parts that can generate non-uniform rational B-splines (NURBS) surfaces with high fidelity and flexibility. The contributions of this study include three parts: first, a dataset of two-dimensional images is constructed for typical industrial parts, including hexagonal head bolts, cylindrical gears, shoulder rings, hexagonal nuts, and cylindrical roller bearings; second, a deep learning algorithm is developed for parameter extraction of 3D industrial parts, which can determine the final 3D parameters and pose information of the reconstructed model using two new nets, CAD-ClassNet and CAD-ReconNet; and finally, a 3D vector shape reconstruction of mechanical parts is presented to generate NURBS from the obtained shape parameters...
March 27, 2024: Visual computing for industry, biomedicine and art
https://read.qxmd.com/read/38531733/preparation-of-diblock-copolymer-nano-assemblies-by-ultrasonics-assisted-ethanol-phase-polymerization-induced-self-assembly
#15
JOURNAL ARTICLE
Xin Shao, Dan Li, Shengwei Guo, Jun Yan, Yongqiang Qian, Guxia Wang
Assemblies are widely used in biomedicine, batteries, functional coatings, Pickering emulsifiers, hydrogels, and luminescent materials. Polymerization-induced self-assembly (PISA) is a method for efficiently preparing particles, mainly initiated thermally. However, thermally initiated PISA usually requires a significant amount of time and energy. Here, we demonstrate the preparation of nano-assemblies with controllable morphologies and size using ultrasound (20 kHz) assisted ethanol-phase RAFT-PISA in three hours...
March 23, 2024: Ultrasonics Sonochemistry
https://read.qxmd.com/read/38531147/mob-cbam-a-dual-channel-attention-based-deep-learning-generalizable-model-for-breast-cancer-molecular-subtypes-prediction-using-mammograms
#16
JOURNAL ARTICLE
Iqra Nissar, Shahzad Alam, Sarfaraz Masood, Mohammad Kashif
BACKGROUND AND OBJECTIVE: Deep Learning models have emerged as a significant tool in generating efficient solutions for complex problems including cancer detection, as they can analyze large amounts of data with high efficiency and performance. Recent medical studies highlight the significance of molecular subtype detection in breast cancer, aiding the development of personalized treatment plans as different subtypes of cancer respond better to different therapies. METHODS: In this work, we propose a novel lightweight dual-channel attention-based deep learning model MOB-CBAM that utilizes the backbone of MobileNet-V3 architecture with a Convolutional Block Attention Module to make highly accurate and precise predictions about breast cancer...
March 10, 2024: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38531121/a-next-generation-peripherally-restricted-cav%C3%AE-2%C3%AE-1-ligand-with-inhibitory-action-on-cav2-2-channels-and-utility-in-neuropathic-pain
#17
JOURNAL ARTICLE
Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris
The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus of human Cavα2δ-1...
March 25, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38531120/effects-of-endogenous-dha-milk-and-exogenous-dha-milk-on-oxidative-stress-and-cognition-in-samp8-mice
#18
JOURNAL ARTICLE
Xiaodan Wang, Huiquan Zhu, Baorong Chen, Yumeng Zhang, Akke Kok, Ariette van Knegsel, Shuwen Zhang, Xiaoyang Pang, Shilong Jiang, Bas Kemp, Jing Lu, Jiaping Lv
In this study, Senescence Accelerated Mice (SAMP8) were supplemented with exogenous DHA milk, endogenous DHA milk, normal milk, or 0.9 % saline solution. Enzyme-linked immunosorbent assay (ELISA), gas chromatography (GC), ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI MS/MS), and Morris water maze were used to characterize the effects of diet on oxidative stress and cognition in SAMP8 mice. Supplementation endogenous DHA milk or exogenous DHA milk can enhance the antioxidant capacity of mice organs...
March 25, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38529077/a-survey-of-recent-methods-for-addressing-ai-fairness-and-bias-in-biomedicine
#19
Yifan Yang, Mingquan Lin, Han Zhao, Yifan Peng, Furong Huang, Zhiyong Lu
Artificial intelligence (AI) systems have the potential to revolutionize clinical practices, including improving diagnostic accuracy and surgical decision-making, while also reducing costs and manpower. However, it is important to recognize that these systems may perpetuate social inequities or demonstrate biases, such as those based on race or gender. Such biases can occur before, during, or after the development of AI models, making it critical to understand and address potential biases to enable the accurate and reliable application of AI models in clinical settings...
February 13, 2024: ArXiv
https://read.qxmd.com/read/38528462/single-cell-transcriptional-signature-based-drug-repurposing-and-in-vitro-evaluation-in-colorectal-cancer
#20
JOURNAL ARTICLE
Roohallah Mahdi-Esferizi, Zahra Shiasi, Razieh Heidari, Ali Najafi, Issa Mahmoudi, Fatemeh Elahian, Shahram Tahmasebian
BACKGROUND: The need for intelligent and effective treatment of diseases and the increase in drug design costs have raised drug repurposing as one of the effective strategies in biomedicine. There are various computational methods for drug repurposing, one of which is using transcription signatures, especially single-cell RNA sequencing (scRNA-seq) data, which show us a clear and comprehensive view of the inside of the cell to compare the state of disease and health. METHODS: In this study, we used 91,103 scRNA-seq samples from 29 patients with colorectal cancer (GSE144735 and GSE132465)...
March 25, 2024: BMC Cancer
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