keyword
MENU ▼
Read by QxMD icon Read
search

biomedicine

keyword
https://www.readbyqxmd.com/read/27910924/high-yield-fabrication-and-properties-of-1-4%C3%A2-nm-nanodiamonds-with-narrow-size-distribution
#1
Stepan Stehlik, Marian Varga, Martin Ledinsky, Daria Miliaieva, Halyna Kozak, Viera Skakalova, Clemens Mangler, Timothy J Pennycook, Jannik C Meyer, Alexander Kromka, Bohuslav Rezek
Detonation nanodiamonds (DNDs) with a typical size of 5 nm have attracted broad interest in science and technology. Further size reduction of DNDs would bring these nanoparticles to the molecular-size level and open new prospects for research and applications in various fields, ranging from quantum physics to biomedicine. Here we show a controllable size reduction of the DND mean size down to 1.4 nm without significant particle loss and with additional disintegration of DND core agglutinates by air annealing, leading to a significantly narrowed size distribution (±0...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910120/at-the-margins-of-biomedicine-the-ambiguous-position-of-registered-medical-practitioners-in-rural-indian-healthcare
#2
Papreen Nahar, Nanda Kishore Kannuri, Sitamma Mikkilineni, G V S Murthy, Peter Phillimore
This analysis challenges a tendency in public health and the social sciences to associate India's medical pluralism with a distinction between biomedicine, as a homogeneous entity, and its non-biomedical 'others'. We argue that this overdrawn dichotomy obscures the important part played by 'informal' biomedical practice, an issue with salience well beyond India. Based on a qualitative study in rural Andhra Pradesh, South India, we focus on a figure little discussed in the academic literature - the Registered Medical Practitioner (RMP) - who occupies a niche in the medical market-place as an informal exponent of biomedical treatment...
December 2, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27908601/corrigendum-to-a-pregnancy-with-discordant-fetal-and-placental-chromosome-18-aneuploidies-revealed-by-invasive-and-noninvasive-prenatal-diagnosis-reproductive-biomedicine-online-29-2014-136-139
#3
Chong Chen, David S Cram, Fanni Xie, Ping Wang, Xueqin Xu, Huanzheng Li, Zhuo Song, Di Chen, Jianguang Zhang, Shaohua Tang
No abstract text is available yet for this article.
November 28, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27906976/a-laboratory-critical-incident-and-error-reporting-system-for-experimental-biomedicine
#4
Ulrich Dirnagl, Ingo Przesdzing, Claudia Kurreck, Sebastian Major
We here propose the implementation of a simple and effective method to enhance the quality of basic and preclinical academic research: critical incident reporting (CIR). CIR has become a standard in clinical medicine but to our knowledge has never been implemented in the context of academic basic research. We provide a simple, free, open-source software tool for implementing a CIR system in research groups, laboratories, or large institutions (LabCIRS). LabCIRS was developed, tested, and implemented in our multidisciplinary and multiprofessional neuroscience research department...
December 2016: PLoS Biology
https://www.readbyqxmd.com/read/27901170/bilayer-hydrogel-actuators-with-tight-interfacial-adhesion-fully-constructed-from-natural-polysaccharides
#5
Jiangjiang Duan, Xichao Liang, Kunkun Zhu, Jinhua Guo, Lina Zhang
Smart hydrogel actuators with excellent biocompatibility and biodegradation are extremely desired for biomedical applications. Herein, we have constructed bio-hydrogel actuators inspired by the bilayer structures of plant organs from chitosan and cellulose/carboxymethylcellulose (CMC) solution in an alkali/urea aqueous system containing epichlorohydrin (ECH) as a crosslinker, and demonstrated tight adhesion between two layers through strong electrostatic attraction and chemical crosslinking. The bilayer hydrogels with excellent mechanical properties could carry out rapid, reversible, and repeated self-rolling deformation actuated by pH-triggered swelling/deswelling, and transformed into rings, tubules, and flower-, helix-, bamboo-, and wave-like shapes by effectively designing the geometric shape and size...
November 30, 2016: Soft Matter
https://www.readbyqxmd.com/read/27901141/assembly-of-1d-nanofibers-into-a-2d-bi-layered-composite-nanofibrous-film-with-different-functionalities-at-the-two-layers-via-layer-by-layer-electrospinning
#6
Zijiao Wang, Qianli Ma, Xiangting Dong, Dan Li, Xue Xi, Wensheng Yu, Jinxian Wang, Guixia Liu
A two-dimensional (2D) bi-layered composite nanofibrous film assembled by one-dimensional (1D) nanofibers with trifunctionality of electrical conduction, magnetism and photoluminescence has been successfully fabricated by layer-by-layer electrospinning. The composite film consists of a polyaniline (PANI)/Fe3O4 nanoparticle (NP)/polyacrylonitrile (PAN) tuned electrical-magnetic bifunctional layer on one side and a Tb(TTA)3(TPPO)2/polyvinylpyrrolidone (PVP) photoluminescent layer on the other side, and the two layers are tightly combined face-to-face together into the novel bi-layered composite film of trifunctionality...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27899636/the-monarch-initiative-an-integrative-data-and-analytic-platform-connecting-phenotypes-to-genotypes-across-species
#7
Christopher J Mungall, Julie A McMurry, Sebastian Köhler, James P Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn, Mark Engelstad, Erin Foster, J P Gourdine, Julius O B Jacobsen, Dan Keith, Bryan Laraway, Suzanna E Lewis, Jeremy NguyenXuan, Kent Shefchek, Nicole Vasilevsky, Zhou Yuan, Nicole Washington, Harry Hochheiser, Tudor Groza, Damian Smedley, Peter N Robinson, Melissa A Haendel
The correlation of phenotypic outcomes with genetic variation and environmental factors is a core pursuit in biology and biomedicine. Numerous challenges impede our progress: patient phenotypes may not match known diseases, candidate variants may be in genes that have not been characterized, model organisms may not recapitulate human or veterinary diseases, filling evolutionary gaps is difficult, and many resources must be queried to find potentially significant genotype-phenotype associations. Non-human organisms have proven instrumental in revealing biological mechanisms...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27897014/the-training-of-next-generation-data-scientists-in-biomedicine
#8
Lana X Garmire, Stephen Gliske, Quynh C Nguyen, Jonathan H Chen, Shamim Nemati, John D VAN Horn, Jason H Moore, Carol Shreffler, Michelle Dunn
With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27897013/harnessing-big-data-for-precision-medicine-infrastructures-and-applications
#9
Kun-Hsing Yu, Steven N Hart, Rachel Goldfeder, Qiangfeng Cliff Zhang, Stephen C J Parker, Michael Snyder
Precision medicine is a health management approach that accounts for individual differences in genetic backgrounds and environmental exposures. With the recent advancements in high-throughput omics profiling technologies, collections of large study cohorts, and the developments of data mining algorithms, big data in biomedicine is expected to provide novel insights into health and disease states, which can be translated into personalized disease prevention and treatment plans. However, petabytes of biomedical data generated by multiple measurement modalities poses a significant challenge for data analysis, integration, storage, and result interpretation...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896967/methods-to-ensure-the-reproducibility-of-biomedical-research
#10
Konrad J Karczewski, Nicholas P Tatonetti, Arjun K Manrai, Chirag J Patel, C Titus Brown, John P A Ioannidis
Science is not done in a vacuum - across fields of biomedicine, scientists have built on previous research and used data published in previous papers. A mainstay of scientific inquiry is the publication of one's research and recognition for this work is given in the form of citations and notoriety - ideally given in proportion to the quality of the work. Academic incentives, however, may encourage individual researchers to prioritize career ambitions over scientific truth. Recently, the New England Journal of Medicine published a commentary calling scientists who repurpose data "research parasites" who misuse data generated by others to demonstrate alternative hypotheses...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27887850/laser-flow-cytometry-as-a-tool-for-the-advancement-of-clinical-medicine
#11
REVIEW
David Aebisher, Dorota Bartusik, Jacek Tabarkiewicz
Flow cytometry is a classic laser technology. With the discovery of the cytometer, flow cytometry has become a primary tool in biodiagnostic research. This review focuses on current applications of flow cytometry to the diagnosis of disease and treatment monitoring at the single-cell level. A description of the principles of flow cytometry and a brief overview of the major applications are presented. Our criteria for selecting research papers for this review are those that show advances in biomedicine and pharmacotherapy achieved by using non-invasive flow cytometry...
November 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27884731/time-lapse-microscopy-patent-upheld-in-europe
#12
David Pearce
A case for revoking Stanford University's European patent 2430454 on time-lapse microscopy was set out in Reproductive BioMedicine Online by Sterckx et al. in 2014, on the grounds that the patent claimed a method of diagnosis that was excluded under a provision of the European Patent Convention. An opposition at the European Patent Office in which this ground was raised has recently concluded with a decision that the patent is not excluded from patentability under European patent law and is to be upheld. An appeal from this decision has been filed, but the possibility of the decision being overturned is, in this author's opinion, very limited...
November 14, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27881214/zinc-ii-ion-promotes-anti-inflammatory-effects-of-rhsod3-by-increasing-cellular-association
#13
Younghwa Kim, Yoon-Jae Jeon, Kang Ryu, Tae-Yoon Kim
Recently, we demonstrated that superoxide dismutase 3 (SOD3) is a strong biomedicine candidate. SOD3 accomplished anti-oxidant function without cell penetration and inhibited inflammatory responses via non-enzymatic functions. SOD3 has the heparin binding domain associating cell surface. Interestingly, we have found that Zn2+ promotes transduction effects of recombinant human SOD3 (rhSOD3) by increasing uptake via heparin binding domain (HBD). We showed an uptake of rhSOD3 from media to cell lysate via HBD, resulting in an accumulation of rhSOD3 into the nucleus, which is promoted by the presence of Zn2+...
November 24, 2016: BMB Reports
https://www.readbyqxmd.com/read/27879342/tenacious-assumptions-of-person-centred-care-exploring-tensions-and-variations-in-practice
#14
Öncel Naldemirci, Doris Lydahl, Nicky Britten, Mark Elam, Lucy Moore, Axel Wolf
In recent decades, the 'tenacious assumptions' of biomedicine regarding the neutrality and universality of its knowledge claims have been significantly challenged by the growth of new collaborative and patient-focused models of Healthcare delivery. In this article, we discuss and critically reflect upon one such alternative Healthcare model developed at the University of Gothenburg Centre for Person-Centred Care in Sweden. This centre uses three clinical routines of narrative, partnership and documentation to provide Healthcare to people recognized as unique individuals rather than patients...
November 22, 2016: Health (London)
https://www.readbyqxmd.com/read/27878530/gendered-medicinal-plant-knowledge-contributions-to-adaptive-capacity-and-health-sovereignty-in-amazonia
#15
Isabel Díaz-Reviriego, Álvaro Fernández-Llamazares, Matthieu Salpeteur, Patricia L Howard, Victoria Reyes-García
Local medical systems are key elements of social-ecological systems as they provide culturally appropriate and locally accessible health care options, especially for populations with scarce access to biomedicine. The adaptive capacity of local medical systems generally rests on two pillars: species diversity and a robust local knowledge system, both threatened by local and global environmental change. We first present a conceptual framework to guide the assessment of knowledge diversity and redundancy in local medicinal knowledge systems through a gender lens...
December 2016: Ambio
https://www.readbyqxmd.com/read/27878196/self-propelled-round-trip-motion-of-janus-particles-in-static-line-optical-tweezers
#16
Jing Liu, Hong-Lian Guo, Zhi-Yuan Li
Controlled propulsion of microparticles and micromachines in fluids could revolutionize many aspects of technology, such as biomedicine, microfluidics, micro-mechanics, optomechanics, and cell biology. We report the self-propelled cyclic round-trip motion of metallo-dielectric Janus particles in static line optical tweezers (LOT). The Janus particle is a 5 μm-diameter polystyrene sphere half-coated with 3 nanometer thick gold film. Both experiment and theory show that this cyclic translational and rotational motion is a consequence of the collective and fine action of the gold-face orientation dependent propulsion optical force, the gradient optical force, and the spontaneous symmetry breaking induced optical torque in different regions of the LOT...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27877244/advances-in-imaging-techniques-and-genetically-encoded-probes-for-photoacoustic-imaging
#17
REVIEW
Chengbo Liu, Xiaojing Gong, Riqiang Lin, Feng Liu, Jingqin Chen, Zhiyong Wang, Liang Song, Jun Chu
Photoacoustic (PA) imaging is a rapidly emerging biomedical imaging modality that is capable of visualizing cellular and molecular functions with high detection sensitivity and spatial resolution in deep tissue. Great efforts and progress have been made on the development of various PA imaging technologies with improved resolution and sensitivity over the past two decades. Various PA probes with high contrast have also been extensively developed, with many important biomedical applications. In comparison with chemical dyes and nanoparticles, genetically encoded probes offer easier labeling of defined cells within tissues or proteins of interest within a cell, have higher stability in vivo, and eliminate the need for delivery of exogenous substances...
2016: Theranostics
https://www.readbyqxmd.com/read/27876896/the-reproductive-toxicity-of-cdse-zns-quantum-dots-on-the-in-vivo-ovarian-function-and-in-vitro-fertilization
#18
Gaixia Xu, Guimiao Lin, Suxia Lin, Na Wu, Yueyue Deng, Gang Feng, Qiang Chen, Junle Qu, Danni Chen, Siping Chen, Hanben Niu, Shujiang Mei, Ken-Tye Yong, Xiaomei Wang
Despite the usefulness of quantum dots (QDs) in biomedicine and optoelectronics, their toxicity risks remain a major obstacle for clinical usages. Hence, we studied the reproductive toxicity of CdSe/ZnS QDs on two aspects, (i) in vivo ovarian functions and (ii) in vitro fertilization process. The body weight, estrous cycles, biodistribution of QDs, and oocyte maturation are evaluated on female mice treated with QDs. The mRNA level of the follicle-stimulating hormone receptor (FSHr) and luteinizing hormone receptor (LHr) in ovaries are assayed...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27875111/improving-rural-health-how-system-level-innovation-and-policy-reform-can-enhance-health-outcomes-across-the-united-states
#19
Suhas Gondi, Kavita Patel
The United States is hailed as providing the most advanced health care the world has to offer. With cutting-edge medical devices, groundbreaking procedures, and innovative technologies, our hospitals and medical centers define what the global community sees as modern biomedicine. Engineers and clinicians continue to push and reshape this standard with new inventions enabled by a rapidly developing knowledge base. However, the fruit of this advancement has not benefited Americans equally. Millions still face significant obstacles to access health care, and our rural communities in particular have been left behind (see also "The Challenge of Rural Health Care")...
November 2016: IEEE Pulse
https://www.readbyqxmd.com/read/27872612/systems-biomedicine-of-rabies-delineates-the-affected-signaling-pathways
#20
Sadegh Azimzadeh Jamalkandi, Sayed-Hamidreza Mozhgani, Hamid Gholami Pourbadie, Mehdi Mirzaie, Farshid Noorbakhsh, Behrouz Vaziri, Alireza Gholami, Naser Ansari-Pour, Mohieddin Jafari
The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that causes lethal encephalomyelitis. Although there have been a plethora of studies investigating the etiological mechanism of the rabies virus and many precautionary methods have been implemented to avert the disease outbreak over the last century, the disease has surprisingly no definite remedy at its late stages. The psychological symptoms and the underlying etiology, as well as the rare survival rate from rabies encephalitis, has still remained a mystery...
2016: Frontiers in Microbiology
keyword
keyword
108705
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"