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Franziska Kopp, Thomas Eickner, Stefan Polei, Karen Falke, Martin Witt, Niels Grabow, Oliver Stachs, Rudolf F Guthoff, Tobias Lindner
Local drug delivery systems (DDS) have become a favourable approach for the treatment of numerous diseases. Biomedical imaging techniques such as ultrahigh field magnetic resonance imaging (UHF-MRI) offer unique insight into DDS biodegradation in vivo. We describe the establishment of a 7 Tesla MRI routine for longitudinal in vivo examinations of a subconjunctival DDS for the treatment of glaucoma in a rabbit model. In initial in vitro examinations the T2-relaxation times of the polymeric DDS components were assessed...
November 17, 2017: Scientific Reports
Velichka Andonova, Petya Peneva
BACKGROUND: Solid lipid nanoparticles (SLN) and the next generation of nanostructured lipid carriers (NLC) seem to be a very promising alternative to other colloidal carriers such as liposomes, microemulsions, and polymeric nanoparticles. These combine the advantages of the cited nanocarriers and can improve the dissolution rate in biological fluids, increase the drug absorption, improve the tissue distribution in the target organ, enhance the drug bioavailability and ensure controlled drug release...
November 14, 2017: Current Pharmaceutical Design
S G Rotman, D W Grijpma, R G Richards, T F Moriarty, D Eglin, O Guillaume
No abstract text is available yet for this article.
November 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Shoshiro Yamamoto, Yu Sakurai, Hideyoshi Harashima
Although anti-angiogenic therapy is predicted to be an effective therapy for treating cancer, selectively targeting tumor endothelial cells (TECs), and not normal endothelial cells, remains a major obstacle. Modifying a drug carrier with a targeting ligand is a popular strategy for developing an active-targeting type drug delivery system (DDS). We previously reported that a cyclo(Arg-Gly-Asp-D-Phe-Lys) (cRGD)-equipped liposome that contains encapsulated siRNA (RGD-MEND) achieved an efficient therapeutic outcome in a murine cancer model...
November 7, 2017: International Journal of Pharmaceutics
Seyed Mostafa Nachvak, Hadi Abdollahzad, Roghayeh Mostafai, Shima Moradi, Yahya Pasdar, Mansour Rezaei, Soudabeh Esksndari
Dietary diversity score (DDS) is known as an indicator of food quality. Dietary diversity can promote health status. The aim of this study was determined DDS and its related factors in Kermanshah University of Medical Sciences (KUMS) employees. This cross-sectional study was conducted on 190 employees of KUMS in 2015. According to the population of KUMS centers which were selected randomly (Paramedical, Public Health faculties, Imam Reza Hospital and province health center), subjects were selected by convenience sampling method...
October 2017: Clinical Nutrition Research
Akos Zahar, György Kocsis, Mustafa Citak, Gábor Puskás, Mónika Domahidy, Mária Hajdú, István Antal, Miklós Szendrői
BACKGROUND: Both osteomyelitis and prosthetic joint infection can be treated surgically with the use of antibiotic loaded bone grafts, as part of local antimicrobial therapy. OBJECTIVE: The purpose of the study was to evaluate and to report on a novel, biodegradable, long-acting (4-6 weeks) antibiotic-impregnated bone graft (AIBG). A novel drug delivery system, containing vancomycin, was utilized in a rabbit osteomyelitis model in order to evaluate the antimicrobial efficacy of the antibiotic bone graft...
October 23, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Assala Al Samad, Audrey Bethry, Olga Janouskova, Jérémie Ciccione, Christiane Wenk, Jean-Luc Coll, Gilles Subra, Tomas Etrych, Fawaz El Omar, Youssef Bakkour, Jean Coudane, Benjamin Nottelet
Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated poly(ε-caprolactone) (PCL) platform via an efficient thiol-yne photoaddition. Fine-tuning over the design is achieved, as illustrated with targeting and enzyme-responsive DDS.
November 2, 2017: Macromolecular Rapid Communications
Boon-How Chew, Rimke C Vos, Rebecca K Stellato, Guy E H M Rutten
For people with type 2 diabetes mellitus (T2DM) the daily maintenance of physical and psychological health is challenging. However, the interrelatedness of these two health domains, and of diabetes-related distress (DRD) and depressive symptoms, in the Asian population is still poorly understood. DRD and depressive symptoms have important but distinct influences on diabetes self-care and disease control. Furthermore, the question of whether changes in DRD or depressive symptoms follow a more or less natural course or depend on disease and therapy-related factors is yet to be answered...
2017: Frontiers in Psychology
Ann Goding Sauer, Benmei Liu, Rebecca L Siegel, Ahmedin Jemal, Stacey A Fedewa
Cancer screening prevalence from the Behavioral Risk Factor Surveillance System (BRFSS), designed to provide state-level estimates, and the National Health Interview Survey (NHIS), designed to provide national estimates, are used to measure progress in cancer control. A detailed description of the extent to which recent cancer screening estimates vary by key demographic characteristics has not been previously described. We examined national prevalence estimates for recommended breast, cervical, and colorectal cancer screening using data from the 2012 and 2014 BRFSS and the 2010 and 2013 NHIS...
October 24, 2017: Preventive Medicine
Eric M Montminy, Stephen W Landreneau, Jordan J Karlitz
Here we report a patient diagnosed with small cell lung cancer after first presenting with parathyroid hormone-related peptide-induced hypercalcemic pancreatitis and developed walled-off necrosis that resulted in disruption of the main pancreatic duct. Disconnected duct syndrome (DDS) is a rare syndrome that occurs when the main pancreatic duct exocrine flow is disrupted resulting in leakage of pancreatic enzymes and further inflammatory sequela. To date, no prior reports have described DDS occurring with paraneoplastic reactions...
October 10, 2017: World Journal of Clinical Oncology
Hamid Sharif Nia, Saeed Pahlevan Sharif, Rebecca H Lehto, Kelly A Allen, Amir Hossein Goudarzian, Ameneh Yaghoobzadeh, Mohammad Ali Soleimani
Objective: Limited research has examined the psychometric properties of death depression scales in Persian populations with cardiac disease despite the need for valid assessment tools for evaluating depressive symptoms in patients with life-limiting chronic conditions. The present study aimed at evaluating the reliability and validity of the Persian Version of Death Depression Scale - Revised (DDS-R) in Iranian patients who had recent acute myocardial infarction (AMI). Method: This psychometric study was conducted with a convenience sample of 407 patients with AMI diagnosis who completed the Persian version of the DDS-R...
July 2017: Iranian Journal of Psychiatry
Anna Gergely, Tamás Faragó, Ágoston Galambos, József Topál
There is growing evidence that dog-directed and infant-directed speech have similar acoustic characteristics, like high overall pitch, wide pitch range, and attention-getting devices. However, it is still unclear whether dog- and infant-directed speech have gender or context-dependent acoustic features. In the present study, we collected comparable infant-, dog-, and adult directed speech samples (IDS, DDS, and ADS) in four different speech situations (Storytelling, Task solving, Teaching, and Fixed sentences situations); we obtained the samples from parents whose infants were younger than 30 months of age and also had pet dog at home...
October 23, 2017: Scientific Reports
Takashi Nakamura, Hideyoshi Harashima
Immune checkpoint therapy represents a new, revolutionary type of cancer therapy, but emerging evidence indicates that only a minority of patients will benefit from it. The issue of how to improve and widen the clinical response is a pivotal issue, and combining other types of therapy with immune checkpoint inhibitors is currently under development. A nanotechnology-based drug-delivery system (nano DDS) could be an important contribution to the development of an effective combination therapy. In this document, we review recent findings in the field of tumor immunology, which provide a strategy for an efficient combination therapy, and discuss nano DDS that are associated with cancer immunotherapy and nano DDS strategies based on the immune status in tumor microenvironments...
November 2017: Therapeutic Delivery
Devleena Samanta, Rohan Mehrotra, Katy Margulis, Richard N Zare
Electroresponsive materials are promising carriers for developing drug delivery systems (DDSs) with excellent spatial, temporal, and dosage control over drug release. Current electroresponsive systems use high voltages (2-25 V), are not bioresorbable, or use materials with unknown long-term biocompatibility. We report here a nanocomposite film that is resorbable, electroresponsive at low voltages (<-2 V), and composed of entirely FDA-approved materials. Our DDS is based on poly(methyl methacrylate-co-methacrylic acid), commercially marketed as Eudragit S100 (EGT), which has pH-dependent aqueous solubility...
November 2, 2017: Nanoscale
Qing Guo, Xian-Tao Shen, Yuan-Yuan Li, Shun-Qing Xu
Current treatments for cancer and the central nervous system diseases are limited, partly due to the difficulties posed by the insolubility, poor distribution of drugs among cells and lack of selectivity of drugs, the inability of drugs to cross cellular barriers and blood brain barrier (BBB). Carbon nanotubes (CNTs) possess many distinct properties including good electronic properties, remarkably penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs to cancer and brain...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
Sung-Man Kim, Han-Soo Kim
Extracellular vesicles (EVs) are secreted membrane-enclosed nano-sized particles (40-1,000 nm) that deliver biological information between cells. The molecular composition of these subcellular particles includes growth factor receptors, ligands adhesion proteins, mRNA, miRNAs, lncRNA and lipids that are derived from donor cells. A number of studies demonstrated that stem cell-derived EVs are the key mediator of tissue repair and regeneration in multiple animal disease models. In addition, the composition of these particles is known to be altered in cancer and disease pathology suggesting them for useful in diagnostic and therapeutic purposes...
2017: Stem Cell Investigation
Jiwon Lee, Regena Spratling, Ashley Helvig
Impaired sleep can contribute to conditions such as cardiometabolic disorders, depression, and decreased immune function. Mothers of children with developmental disabilities (DDs) may be at greater risk for impaired sleep due to the sleep problems of their children. This cross-sectional study described the self-reported sleep characteristics of mothers of children (ages 6-12) with DDs by using a sleep diary and the Pittsburgh Sleep Quality Index (PSQI) as quantitative and qualitative measures of sleep in these mothers...
October 19, 2017: Journal of Pediatric Health Care
Chiara Mazzoni, Fabio Tentor, Sophie Andersen Strindberg, Line Hagner Nielsen, Stephan Sylvest Keller, Tommy Sonne Alstrøm, Carsten Gundlach, Anette Müllertz, Paolo Marizza, Anja Boisen
This work explores the potential of polymeric micrometer sized devices (microcontainers) as oral drug delivery systems (DDS). Arrays of detachable microcontainers (D-MCs) were fabricated on a sacrificial layer to improve the handling and facilitate the collection of individual D-MCs. A model drug, ketoprofen, was loaded into the microcontainers using supercritical CO2 impregnation, followed by deposition of an enteric coating to protect the drug from the harsh gastric environment and to provide a fast release in the intestine...
October 18, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Ankita Mohapatra, Michael A Harris, David LeVine, Madhav Ghimire, Jessica A Jennings, Bashir I Morshed, Warren O Haggard, Joel D Bumgardner, Sanjay R Mishra, Tomoko Fujiwara
Local antibiotic delivery can overcome some of the shortcomings of systemic therapy, such as low local concentrations and delivery to avascular sites. A localized drug delivery system (DDS), ideally, could also use external stimuli to modulate the normal drug release profile from the DDS to provide efficacious drug administration and flexibility to healthcare providers. To achieve this objective, chitosan microbeads embedded with magnetic nanoparticles were loaded with the antibiotic vancomycin and stimulated by a high frequency alternating magnetic field...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Abdulaziz Alzahrani, Monday O Ogese, Xioali Meng, James Waddington, Arun Tailor, John Farrell, James L Maggs, Catherine J Betts, B Kevin Park, Dean John Naisbitt
Dapsone (DDS) causes hypersensitivity reactions in 0.5-3.6% of patients. Although clinical diagnosis is indicative of a hypersensitivity reaction, studies have not been performed to define whether dapsone or a metabolite activates specific T-cells. Thus, the aims of this study were to explore the immunogenicity DDS and nitroso DDS (DDS-NO) using PBMC from healthy donors and splenocytes from mice and generate human T-cell clones to characterize mechanisms of T-cell activation. DDS-NO was synthesized from DDS-hydroxylamine and shown to bind to the thiol group of glutathione and human and mouse albumin through sulfonamide and N-hydroxyl sulphonamide adducts...
October 18, 2017: Chemical Research in Toxicology
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