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https://www.readbyqxmd.com/read/28198606/sustained-release-of-brimonidine-from-a-new-composite-drug-delivery-system-for-treatment-of-glaucoma
#1
Jianguo Sun, Yuan Lei, Zhaoxing Dai, Xi Liu, Taomin Huang, Jihong Wu, Zhi Ping Xu, Xinghuai Sun
A novel layered double hydroxide (LDH) nanoparticle/thermogel composite drug delivery system (DDS) for sustained release of brimonidine (Bri) has been designed, prepared and characterized in this study for treatment of severe glaucoma. Brimonidine is first loaded onto LDH (Bri@LDH) nanoparticles, which are then dispersed in the thermogel consisting of plenty of micelles based on poly-(DL-lactic acid co-glycolic acid)-polyethylene glycol-poly-(DL-lactic acid co-glycolic acid) (PLGA-PEG-PLGA) copolymer. The Bri@LDH/Thermogel DDS containing 125...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28197588/an-unexpected-pathway-for-hydrodesulfurization-of-gazole-over-a-comos-active-phase-supported-on-a-mesoporous-tio2-catalyst
#2
I Naboulsi, C Felipe Linares Aponte, B Lebeau, S Brunet, L Michelin, M Bonne, J L Blin
Using dual mesoporous titania as a support, due to the presence of intrinsic Brönsted acid sites, the main approach to 4,6-dimethylbenzothiophene (46DMDBT) hydrodesulfurization (HDS) becomes the direct desulfurization (DDS) route through isomerization and dismutation reactions, instead of the hydrogenation (HYD) pathway usually observed with a conventional promoted (by Ni or Co) MoS2/Al2O3 catalyst.
February 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28196157/dynamic-documentation-of-the-smile-and-the-2d-3d-digital-smile-design-process
#3
Christian Coachman, Marcelo Alexandre Calamita, Newton Sesma
Medical and dental histories, clinical examination, study models, and photographs provide the data for a proper diagnosis and the treatment plan for esthetic dentistry. However, they do not offer all the information necessary to analyze the smile and create harmony with the lips and face without excessive intraoral adjustments. Dentolabial parameters vary according to lip dynamics and are influenced by both a static posed smile and a smile in motion as captured in video. This article describes a documentation protocol using smartphone videos to improve the analysis, smile design decisions, and elaboration of a 2D smile frame that will guide the 3D digital smile design project...
March 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28188463/evaluation-of-psychometric-properties-of-the-second-version-of-the-taqwa-piety-questionnaire-in-bahasa-melayu
#4
Tahereh Seghatoleslam, Hussain Habil, Ahmad Hatim, Abolfazl Ardakani, Khafidz Ishak, Rusdi Rashid
The aim of the study is to evaluate the psychometric properties of the Bahasa Melayu version of the Taqwa (piety) questionnaire, used for the measurement of behaviour of Drug Dependency Syndrome (DDS), in Malay patients. A sample of 98 males with a psychiatric diagnosis (DSM-IV-R) as the DDS was randomly selected from Kajang Khafidz Polyclinic Kuala Lumpur, Malaysia. After receiving their agreement to attend the study, they completed the Taqwa (piety) questionnaire. The reliability was assessed by determining the Cronbach's [Formula: see text] to measure the consistency of related questions for all four dimensions (subscales), including individual, social, cognitional, and emotional Taqwa behaviour...
February 10, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28188235/cannabis-edibles-blood-and-oral-fluid-cannabinoid-pharmacokinetics-and-evaluation-of-oral-fluid-screening-devices-for-predicting-%C3%AE-9-tetrahydrocannabinol-in-blood-and-oral-fluid-following-cannabis-brownie-administration
#5
Matthew N Newmeyer, Madeleine J Swortwood, Maria Andersson, Osama A Abulseoud, Karl B Scheidweiler, Marilyn A Huestis
BACKGROUND: Roadside oral fluid (OF) Δ(9)-tetrahydro-cannabinol (THC) detection indicates recent cannabis intake. OF and blood THC pharmacokinetic data are limited and there are no on-site OF screening performance evaluations after controlled edible cannabis. CONTENT: We reviewed OF and blood cannabinoid pharmacokinetics and performance evaluations of the Draeger DrugTest®5000 (DT5000) and Alere™ DDS®2 (DDS2) on-site OF screening devices. We also present data from a controlled oral cannabis administration session...
February 10, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28186770/biocompatible-reduction-and-ph-dual-responsive-core-cross-linked-micelles-based-on-multi-functional-amphiphilic-linear-hyperbranched-copolymer-for-controlled-anticancer-drug-delivery
#6
Kun Tian, Xu Jia, Xubo Zhao, Peng Liu
Novel strategy has been developed for fabricating the biocompatible reduction and pH dual-responsive core cross-linked (CCL) micelles as drug delivery system (DDS) for the controlled anticancer drug delivery, via the atom transfer radical polymerization (ATRP) of tert-butyl acrylate (tBA) with N,N'-bis (acryloyl)cystamine (BACy) as crosslinker and a multi-functional amphiphilic linear-hyperbranched copolymer as macroinitiator, which was synthesized via the self-condensing vinyl co-polymerization (SCVCP) of tert-butyl acrylate (tBA) and p-chloromethylstyrene (CMS) with a poly(ethylene glycol) (PEG) based initiator (mPEG-Br)...
February 10, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28172486/p022-met-deletion-in-mrp8-neutrophils-is-protective-during-dds-induced-colitis-via-th17-pathway
#7
M Stakenborg, E Meroni, G Goverse, G Matteoli
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28168430/poly-lactic-co-glycolic-acid-drug-delivery-systems-through-transdermal-pathway-an-overview
#8
REVIEW
Lucas Naves, Chetna Dhand, Luis Almeida, Lakshminarayanan Rajamani, Seeram Ramakrishna, Graça Soares
In past few decades, scientists have made tremendous advancement in the field of drug delivery systems (DDS), through transdermal pathway, as the skin represents a ready and large surface area for delivering drugs. Efforts are in progress to design efficient transdermal DDS that support sustained drug release at the targeted area for longer duration in the recommended therapeutic window without producing side-effects. Poly(lactic-co-glycolic acid) (PLGA) is one of the most promising Food and Drug Administration approved synthetic polymers in designing versatile drug delivery carriers for different drug administration routes, including transdermal drug delivery...
February 6, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28168052/dietary-diversity-is-not-associated-with-haematological-status-of-pregnant-women-resident-in-rural-areas-of-northern-ghana
#9
Mahama Saaka, Jeremiah Oladele, Asamoah Larbi, Irmgard Hoeschle-Zeledon
Background. Information regarding how dietary diversity is related to haematological status of the pregnant women in rural areas of Northern Ghana is limited. This study therefore evaluated maternal dietary intake and how it relates to the nutritional status of pregnant women belonging to different socioeconomic conditions in Northern Ghana. Methods. This study was cross-sectional in design involving 400 pregnant women. Midupper arm circumference (MUAC) and anaemia status were used to assess the nutritional status of pregnant women...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28167286/recent-developments-in-anticancer-drug-delivery-using-cell-penetrating-and-tumor-targeting-peptides
#10
REVIEW
Shama Dissanayake, William A Denny, Swarna Gamage, Vijayalekshmi Sarojini
Efficient intracellular trafficking and targeted delivery to the site of action are essential to overcome the current drawbacks of cancer therapeutics. Cell Penetrating Peptides (CPPs) offer the possibility of efficient intracellular trafficking, and, therefore the development of drug delivery systems using CPPs as cargo carriers is an attractive strategy to address the current drawbacks of cancer therapeutics. Additionally, the possibility of incorporating Tumor Targeting Peptides (TTPs) into the delivery system provides the necessary drug targeting effect...
February 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28165814/targeting-delivery-of-simvastatin-using-icam-1-antibody-conjugated-nanostructured-lipid-carriers-for-acute-lung-injury-therapy
#11
Shu-Juan Li, Xiao-Juan Wang, Jing-Bo Hu, Xu-Qi Kang, Li Chen, Xiao-Ling Xu, Xiao-Ying Ying, Sai-Ping Jiang, Yong-Zhong Du
Acute lung injury (ALI) is a critical illness without effective therapeutic modalities currently. Recent studies indicated potential efficacy of statins for ALI, while high-dose statins was suggested to be significant for attenuating inflammation in vivo. Therefore, a lung-targeted drug delivery system (DDS) delivering simvastatin (SV) for ALI therapy was developed, attempting to improve the disease with a decreased dose and minimize potential adverse effects. SV-loaded nanostructured lipid carriers (SV/NLCs) with different size were prepared primarily...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28157422/scalable-preparation-of-poly-ethylene-glycol-grafted-sirna-loaded-lipid-nanoparticles-using-a-commercially-available-fluidic-device-and-tangential-flow-filtration
#12
Yu Sakurai, Tomoya Hada, Hideyoshi Harashima
While a number of siRNA delivery systems have been developed, the methods used in their preparation are not suitable for large-scale production. We herein report on methodology for the large-scale preparation of liposomal siRNA using a fluidic device and tangential flow filtration. A number of studies have appeared on the use of fluidic devices for preparing and purifying liposomes, but no systematic information regarding appropriate membrane type of commercially available apparatus is available. The findings reported herein indicate that, under optimized conditions, a microfluidic device and tangential flow filtration can be used to produce siRNA lipid nanoparticles with the same characteristics as traditional ones'...
February 3, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28154250/albumin-based-nitric-oxide-traffic-system-for-the-treatment-of-intractable-cancers
#13
REVIEW
Yu Ishima
Biomacromolecules (>40 kDa) have been developed as drug delivery system (DDS) carriers of low-molecular weight drugs to promote these drugs' uptake by cancer tissues via enhanced permeability and retention (EPR) effects. Human serum albumin (HSA) has been found to accumulate in cancer tissues via this EPR effect. HSA is the most abundant protein in serum, which performs essential physiological functions such as the transportation of many endogenous and exogenous ligands. Nitric oxide (NO) is a very small ligand of HSA; it is a unique and diffusible molecular messenger that plays a central role in mammalian physiology...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28154249/innovations-in-liposomal-dds-technology-and-its-application-for-the-treatment-of-various-diseases
#14
REVIEW
Naoto Oku
Liposomes have been widely used as drug carriers in the field of drug delivery systems (DDS), and they are thought to be ideal nano-capsules for targeting DDS after being injected into the bloodstream. In general, DDS drugs meet the needs of aged and super-aged societies, since the administration route of drugs can be changed, the medication frequency reduced, the adverse effects of drugs suppressed, and so on. In fact, a number of liposomal drugs have been launched and used worldwide including liposomal anticancer drugs, and these drugs have appeared on the market owing to various innovations in liposomal DDS technologies...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28138388/mental-illness-and-violent-behavior-the-role-of-dissociation
#15
Aliya R Webermann, Bethany L Brand
BACKGROUND: The role of mental illness in violent crime is elusive, and there are harmful stereotypes that mentally ill people are frequently violent criminals. Studies find greater psychopathology among violent offenders, especially convicted homicide offenders, and higher rates of violence perpetration and victimization among those with mental illness. Emotion dysregulation may be one way in which mental illness contributes to violent and/or criminal behavior. Although there are many stereotyped portrayals of individuals with dissociative disorders (DDs) being violent, the link between DDs and crime is rarely researched...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28129763/prediction-of-clinical-outcomes-after-kidney-transplantation-from-deceased-donors-with-acute-kidney-injury-a-comparison-of-the-kdigo-and-akin-criteria
#16
Jeong Ho Kim, Young Soo Kim, Min Seok Choi, Young Ok Kim, Sun Ae Yoon, Ji-Il Kim, In Sung Moon, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Byung Ha Chung
BACKGROUND: Acute kidney injury (AKI) is frequently detected in deceased donors (DDs), and it could be associated with adverse clinical outcomes in corresponding kidney transplant recipients (KTRs). In this regard, we sought to identify which criteria is better between the KDIGO and AKIN criteria for the diagnosis of AKI in DDs in the prediction of clinical outcomes after kidney transplantation (KT). METHODS: Two hundred eighty-five cases of deceased donor kidney transplantation (DDKT) were included...
January 27, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28117965/photosensitizer-decorated-red-blood-cells-as-an-ultra-sensitive-light-responsive-drug-delivery-system
#17
Min Gao, Aiyan Hu, Xiaoqi Sun, Chao Wang, Ziliang Dong, Liangzhu Feng, Zhuang Liu
Red blood cells (RBCs), the most abundant type of cells in our blood, have shown promises as a natural drug delivery system (DDS) with inherent biocompatibility. Herein, we uncover that a photosensitizer, chlorin e6 (Ce6), could be decorated into the membrane of RBCs upon simple mixing, without affecting the membrane integrity and stability in dark. Upon light irradiation with a rather low power density, the generated singlet oxygen by Ce6 as the result of photodynamic effect would lead to rather efficient disruption of RBC membrane...
January 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28114570/sustained-subconjunctival-delivery-of-infliximab-protects-the-cornea-and-retina-following-alkali-burn-to-the-eye
#18
Chengxin Zhou, Marie-Claude Robert, Vassiliki Kapoulea, Fengyang Lei, Anna M Stagner, Frederick A Jakobiec, Claes H Dohlman, Eleftherios I Paschalis
Purpose: Tumor necrosis factor (TNF)-α is upregulated in eyes following corneal alkali injury and contributes to corneal and also retinal damage. Prompt TNF-α inhibition by systemic infliximab ameliorates retinal damage and improves corneal wound healing. However, systemic administration of TNF-α inhibitors carries risk of significant complications, whereas topical eye-drop delivery is hindered by poor ocular bioavailability and the need for patient adherence. This study investigates the efficacy of subconjunctival delivery of TNF-α antibodies using a polymer-based drug delivery system (DDS)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28106372/folate-engineered-microvesicles-for-enhanced-target-and-synergistic-therapy-toward-breast-cancer
#19
Lian Zhu, Di Dong, Zi-Li Yu, Yi-Fang Zhao, Dai-Wen Pang, Zhi-Ling Zhang
As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for packaging kinds of functional molecules for effective tumor diagnosis and therapy; however, the deficiency of their tumor targeting influenced their therapy efficacy. Through a facile phospholipid substitution strategy, MVs-based drug delivery system (DDS) was apparently endowed with high tumor targeting toward breast cancer thanks to the modified folate onto the membrane of MVs, simultaneously possessing a synergistic antitumor effect, and in vivo tumor imaging attributed to the SA-QDs labeling...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28081536/wt1-haploinsufficiency-supports-milder-renal-manifestation-in-two-patients-with-denys-drash-syndrome
#20
Mara S Guaragna, Juliana G Ribeiro de Andrade, Bárbara de Freitas Carli, Vera M S Belangero, Andréa T Maciel-Guerra, Gil Guerra-Júnior, Maricilda P de Mello
Denys-Drash syndrome (DDS) is characterized by nephropathy, genital abnormalities, and predisposition to Wilms' tumor. DDS patients usually present heterozygous de novo germline WT1 mutations. The WT1 gene comprises 10 exons encoding the N-terminal transactivation and the C-terminal DNA-binding regions. Two unrelated patients with genital ambiguity and Wilms' tumor were analyzed by sequencing of the WT1 gene, and 3 mutations in exon 1 were identified of which 2 are novel. Patient 1 carried a c.555delC mutation that causes a frameshift and a premature stop codon...
January 13, 2017: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
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