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Vicky Duffy, Daniel Gomez, Peter Rycus, Brian Rivera, Stephanie L Santoro, Carl H Backes, Clifford L Cua
Patients with Down syndrome (DS) may have multiple medical issues that place them at risk for requiring extracorporeal membrane oxygenation. Use of extracorporeal membrane oxygenation in pediatric patients with Down syndrome has been described, but minimal data exist for extracorporeal membrane oxygenation use in adults with Down syndrome. The goal of this study was to describe the clinical characteristics and to determine if there were differences between adult extracorporeal membrane oxygenation patients with Down syndrome that were alive (aDS) versus those that died (dDS) prior to hospital discharge...
May 17, 2018: Artificial Organs
Majed O Aljuaid, Abdulmajeed M Almutairi, Mohammed A Assiri, Dhifallah M Almalki, Khaled Alswat
Background and Objectives: Diabetes is one of the most common chronic diseases; it is a debilitating and hard to live with. Diabetes-related distress (DRD) refers to the emotional and behavioral changes caused by diabetes. Our study aims to assess the prevalence of DRD among type 2 diabetes (T2D) patients using Diabetes Distress Scale-17 items (DDS-17) and its relation to complications and treatment modalities. Methods: A cross-sectional study of adult T2D patients with follow-up visits at the Diabetes and Endocrinology Center in Taif, Saudi Arabia, between January and July 2017...
2018: Journal of Diabetes Research
C T Moody, B L Baker, J Blacher
BACKGROUND: Despite studies of how parent-child interactions relate to early child language development, few have examined the continued contribution of parenting to more complex language skills through the preschool years. The current study explored how positive and negative parenting behaviours relate to growth in complex syntax learning from child age 3 to age 4 years, for children with typical development or developmental delays (DDs). METHODS: Participants were children with or without DD (N = 60) participating in a longitudinal study of development...
May 10, 2018: Journal of Intellectual Disability Research: JIDR
Hoon Hyun, Min Ho Park, Wonbong Lim, So Yeon Kim, Danbi Jo, Jin Seok Jung, Gayoung Jo, Sewook Um, Deok-Won Lee, Dae Hyeok Yang
Currently available chemotherapy is associated with serious side effects, and therefore novel drug delivery systems (DDSs) are required to specifically deliver anticancer drugs to targeted sites. In this study, we evaluated the feasibility of visible light-cured glycol chitosan (GC) hydrogels with controlled release of doxorubicin⋅hydrochloride (DOX⋅HCl) as local DDSs for effective cancer therapy in vivo. The storage modulus of the hydrogel precursor solutions was increased as a function of visible light irradiation time...
May 11, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Dr Karishma Manji
No abstract text is available yet for this article.
May 11, 2018: British Dental Journal
Taiki Hayashi, Matsumi Shinagawa, Tsuyoshi Kawano, Takashi Iwasaki
Cell-penetrating peptides (CPPs) can deliver payloads into cells by forming complexes with bioactive molecules via covalent or non-covalent bonds. Various CPPs have been applied in CPP-modified liposomes, and their effectiveness is highly regarded in liposomal drug delivery systems (DDSs). Previously, we have reported on the polyhistidine peptide (H16 peptide: HHHHHHHHHHHHHHHH-NH2 ) as a new CPP. The H16 peptide has a higher cell-penetrating capacity than well-known CPPs and delivers small molecules such as fluorescent dyes, bioactive peptides, and proteins into mammalian cells...
May 7, 2018: Biochemical and Biophysical Research Communications
Kang Fang, Yajuan Li, Xueying Yin, Abdus Samad, Tengchuan Jin
BACKGROUND: Death domain superfamily are compact structural motifs that play critical roles in many biological processes including inflammation and apoptosis. Due to mediating protein-protein interactions, these death domains have a high tendency to form oligomers and are notoriously difficult to deal with when overexpressed in vitro. In this study, we found that maltose binding protein (MBP) is very effective in improving the behavior of many death domain superfamily members. METHODS: In order to achieve high-level expression of death domain superfamily in E...
April 1, 2018: Clinical Laboratory
Ting Zhang, Zhiyuan Li, Ting Liu, Suxia Li, Hua Gao, Chao Wei, Weiyun Shi
Cyclosporine A (CsA) is an essential medication used to prevent corneal allograft rejection. Our preliminary studies revealed that CsA drug-delivery system (DDS) was more effective in preventing high-risk corneal allograft rejection than topical CsA application. However, the impacts of CsA DDS on the intraocular immune microenvironment were not fully elucidated. In the present study, we investigated the effect of CsA DDS on the cornea allograft, aqueous humor, and iris-ciliary body using a rabbit model of high-risk penetrating keratoplasty...
2018: PloS One
Renata Grifantini, Monia Taranta, Lisa Gherardini, Ilaria Naldi, Matteo Parri, Alberto Grandi, Ambra Giannetti, Sara Tombelli, Gioia Lucarini, Leonardo Ricotti, Susanna Campagnoli, Elisa De Camilli, Gualtiero Pelosi, Francesco Baldini, Arianna Menciassi, Giuseppe Viale, Piero Pileri, Caterina Cinti
Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. The currently approved therapeutic agents show a rather limited efficacy. We have recently demonstrated that the atypical cadherin FAT1 is a specific marker of CRC and that the FAT1-specific monoclonal antibody mAb198.3 may offer new therapeutic opportunities for CRC, being efficiently internalized by cancer cells and reducing cancer growth in colon cancer xenograft models. In this study we explored the therapeutic efficacy of mAb198...
May 4, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Manjunatha Kogenaru, Mark Isalan
Destabilizing domains (DDs) are genetic tags that conditionally control the level of abundance of proteins-of-interest (POI) with specific stabilizing small-molecule drugs, rapidly and reversibly, in a wide variety of organisms. The amount of the DD-tagged fusion protein directly impacts its molecular function. Hence, it is important that the background levels be tightly regulated in the absence of any drug. This is especially true for classes of proteins that function at extremely low levels, such as lethality genes involved in tissue development and certain transcriptional activator proteins...
May 7, 2018: ACS Synthetic Biology
Bingjun Sun, Cong Luo, Han Yu, Xuanbo Zhang, Qin Chen, Wenqian Yang, Menglin Wang, Qiming Kan, Haotian Zhang, Yongjun Wang, Zhonggui He, Jin Sun
Disulfide bond has been widely used to develop reduction-responsive drug delivery system (DDS) for cancer therapy. But we propose that the disulfide bond might be also used as an oxidation-responsive linkage just like thioether bond, which can be oxidized to hydrophilic sulfoxide or sulphone in the presence of oxidation stimuli. To test our hypothesis, we design three novel paclitaxel-citronellol conjugates, linked via different lengths of disulfide bond-containing carbon chain. The prodrugs can self-assemble into uniform size nanoparticles with impressive high drug loading (>55%)...
May 4, 2018: Nano Letters
Graziella Anselmo Joanitti, Rupa S Sawant, Vladimir P Torchilin, Sonia Maria de Freitas, Ricardo Bentes Azevedo
One of the major challenges in the administration of therapeutic proteins involves delivery limitations. Liposomes are well-known drug delivery systems (DDS) that have been used to overcome this drawback; nevertheless, low protein entrapment efficiency (EE) still limits their wide biomedical application on a commercial scale. In the present work, different methods for protein entrapment into liposomes were tested in order to obtain tailored DDS platforms for multiple biomedical applications. The protein used as model was the Black-eyed pea Trypsin and Chymotrypsin Inhibitor (BTCI), a member of the Bowman-Birk protease inhibitor family (BBIs), which has been largely explored for its potential application in many biomedical therapies...
April 20, 2018: Colloids and Surfaces. B, Biointerfaces
Amr Hodhod, Mohamed El-Sherbiny
Denys Drash Syndrome (DDS) is a combination of genital and urinary anomalies that mostly associated with renal and gonadal malignancies. We report 2 patients who presented with genital ambiguity and were diagnosed as 46XY DDS. Both patients had renal masses during follow up and underwent partial nephrectomy aiming to have transplant at older age.
April 30, 2018: Urology
Aaron Parzuchowski, Rizvan Bush, Qinglin Pei, Debra L Friedman, Thomas J FitzGerald, Suzanne L Wolden, Kavita V Dharmarajan, Louis S Constine, Fran Laurie, Sandy K Kessel, Burton Appel, Karen Fernandez, Angela Punnett, Cindy L Schwartz, Jacob Cox, Stephanie A Terezakis
PURPOSE: The presented protocol for pediatric intermediate-risk Hodgkin lymphoma evaluated the use of a dose-intensive chemotherapy regimen (ABVE-PC [doxorubicin, bleomycin, vincristine, etoposide, cyclophosphamide, prednisone]) with response-based therapy augmentation (addition of DECA [dexamethasone, etoposide, cisplatin, cytarabine]) or therapy reduction (elimination of radiation). METHODS AND MATERIALS: A central review of the radiation therapy data for quality assurance was performed, and the association between radiation protocol deviation (RPD) and relapse was assessed in the pediatric group (age <15 years) and adolescent and young adult (AYA) group (age ≥15-21 years)...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
K Madhumathi, Y Rubaiya, Mukesh Doble, R Venkateswari, T S Sampath Kumar
A dual local drug delivery system (DDS) composed of calcium phosphate bioceramic nanocarriers aimed at treating the antibacterial, anti-inflammatory, and bone-regenerative aspects of periodontitis has been developed. Calcium-deficient hydroxyapatite (CDHA, Ca/P = 1.61) and tricalcium phosphate (β-TCP) were prepared by microwave-accelerated wet chemical synthesis method. The phase purity of the nanocarriers was confirmed by x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR), while the transmission electron microscopy (TEM) confirmed their nanosized morphology...
May 1, 2018: Drug Delivery and Translational Research
Masoud Arablu, Sajad Kafashi, Stuart T Smith
A novel Radio-Frequency Frequency-Modulated (RF-FM) signal generation method is introduced and a prototype circuit developed to evaluate its functionality and performance. The RF-FM signal generator uses a modulated, voltage-controlled time delay to correspondingly modulate the phase of a 10 MHz sinusoidal reference signal. This modulated reference signal is, in turn, used to clock a Direct Digital Synthesizer (DDS) circuit resulting in an FM signal at its output. The modulating signal that is input to the voltage-controlled time delay circuit is generated by another DDS that is synchronously clocked by the same 10 MHz sine wave signal before modulation...
April 2018: Review of Scientific Instruments
Yuichiro Morishita, Zorica Buser, Anthony D'Oro, Keiichiro Shiba, Jeffrey C Wang
Study Design: Retrospective, observational, case series. Purpose: To elucidate the prevalence of degenerative changes in the cervical and lumbar spine and estimate the degenerative changes in the cervical spine based on the degeneration of lumbar disc through a retrospective review of magnetic resonance (MR) images. Overview of Literature: Over 50% of middle-aged adults show evidence of spinal degeneration. However, the relationship between degenerative changes in the cervical and lumbar spine has yet to be elucidated...
April 2018: Asian Spine Journal
Hiroto Hatakeyama
 Nucleic acid therapy is expected to be a next generation medicine. We recently developed a multifunctional envelope-type nano device (MEND) for use as a novel delivery system. The modification of polyethylene glycol (PEG), i.e., PEGylation, is useful for achieving the delivery of MENDs to tumors via an enhanced permeability and retention (EPR) effect. However, PEGylation strongly inhibits the cellular uptake and endosomal escape of MEND, which results in significant loss of action, and therefore lost effectiveness, of the cargo therapeutic...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Hui Chen, Zhongyin Chen, Ying Kuang, Shuang Li, Min Zhang, Jia Liu, Zhengguang Sun, Bingbing Jiang, Xueqin Chen, Cao Li
Due to the difference of pH values between normal tissues, tumor tissues and intracellular environments, DOX@MSN-CD-PEG, a stepwise-acid-active organic/inorganic hybrid drug delivery system (DDS) was reported in this article. The inorganic mesoporous silica nanoparticle (MSN) was introduced for loading of doxorubicin hydrochloride (DOX). Then organic components were applied to achieve the stepwise-acid-active intracellular drug release: MSN was capped with a β-cyclodextrine (β-CD) based host-guest system via pH-sensitive epoxy bond...
April 21, 2018: Colloids and Surfaces. B, Biointerfaces
Ying Zhang, Xiaowen Wu, Chenxi Hou, Kun Shang, Kui Yang, Zhimin Tian, Zhichao Pei, Yongquan Qu, Yuxin Pei
Objective: The aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery. Methods: A multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO2 nanorods and subsequent conjugation of lactose derivative, where the PDS was formed by self-polymerization of dithio-dopamine (DOPASS). Results: The multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells...
2018: International Journal of Nanomedicine
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