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https://www.readbyqxmd.com/read/27890899/drug-delivery-system-of-therapeutic-oligonucleotides
#1
Yutaro Asami, Kotaro Yoshioka, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota
Therapeutic oligonucleotides are promising technologies. Nevertheless, improvement of their efficacy is an important issue. Introducing this drug delivery system (DDS) makes for a great enhancement for delivery of oligonucleotides to targeted tissue or cells. The strategy of DDS for therapeutic oligonucleotides is divided into four categories, A) single piece of oligonucleotide, B) oligonucleotide-ligand conjugate, C) oligonucleotide-polymer conjugate, and D) nanoparticle. In this review we will describe those basic concepts, especially for the technology of conjugating ligand...
2016: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/27886551/reconsidering-azobenzene-as-a-component-of-small-molecule-hypoxia-mediated-cancer-drugs-a-theranostic-case-study
#2
Peter Verwilst, Jiyou Han, Jiyeong Lee, Sora Mun, Hee-Gyoo Kang, Jong Seung Kim
An azobenzene scaffold serves as both a fluorescence quencher and nitrogen mustard deactivator in a mitochondrial targeting unit bearing theranostic drug delivery system (DDS). The DDS exhibited a tissue selectivity for tumors with aggressive phenotypes, and the efficient in vitro and in vivo azoreduction under hypoxia conditions resulted in bright fluorescence at the tumor site as well as the in situ activation of the prodrug. In vivo therapeutic experiments demonstrated a significant reduction in tumor growth versus number of controls and ex vivo tissue analysis confirmed tissue normalization with strongly reduced angiogenic markers and suppressed cell proliferation...
November 16, 2016: Biomaterials
https://www.readbyqxmd.com/read/27863657/development-and-characterization-of-polo-like-kinase-2-loaded-nanoparticles-a-novel-strategy-for-serine-129-phosphorylation-of-alpha-synuclein
#3
C Rodríguez-Nogales, E Garbayo, I Martínez-Valbuena, V Sebastián, M R Luquin, M J Blanco-Prieto
Polo like kinase 2 (PLK2), a serine/threonine serum inducible kinase, has been proposed to be the major factor responsible for phosphorylating alpha-synuclein (α-syn) at Serine-129 (Ser-129) in Parkinson's disease (PD). A suitable strategy to gain insights into PLK2's biological effects might be to increase PLK2 intracellular levels with the aim of reproducing the slow progressive neuronal changes that occur in PD. The goal of this study was to develop and characterize a novel drug delivery system (DDS) for PLK2 cytosolic delivery using Total recirculating one machine system (TROMS), a technique capable of encapsulating fragile molecules while maintaining their native properties...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27848939/dietary-diversity-and-adiposity-in-chinese-men-and-women-an-analysis-of-four-waves-of-cross-sectional-survey-data
#4
X Tian, M Wu, J Zang, Y Zhu, H Wang
BACKGROUND/OBJECTIVE: Increasing dietary diversity is concurrent with an increasing prevalence of adiposity in China, but the association between these variables remains ambiguous. This study reveals an association between dietary diversity and body mass (underweight, overweight and obesity) in Chinese adults. SUBJECTS/METHODS: Data from 17 825 participants (age, 18-65 years) were pooled from four survey waves (2004, 2006, 2009 and 2011) of the Chinese Health and Nutrition Survey...
November 16, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27830347/mito-porter-for-mitochondrial-delivery-and-mitochondrial-functional-analysis
#5
Yuma Yamada, Hideyoshi Harashima
Mitochondria are attractive organelles that have the potential to contribute greatly to medical therapy, the maintenance of beauty and health, and the development of the life sciences. Therefore, it would be expected that the further development of mitochondrial drug delivery systems (DDSs) would exert a significant impact on the medical and life sciences. To achieve such an innovative objective, it will be necessary to deliver various cargoes to mitochondria in living cells. However, only a limited number of approaches are available for accomplishing this...
November 10, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27825127/sequential-delivery-of-therapeutic-agents-using-a-rationally-designed-disulfide-linked-glycolipid-like-nanocarrier
#6
Yingwen Hu, Na Liu, Bolin Cheng, Yanan Tan, Lijuan Wen, Hong Yuan, Fuqiang Hu
Usage of combination therapies to deliver multiple therapeutics to increase treatment efficacy has shown promising results in the clinic. In an effort to maximize the synergistic effect of co-delivery of a drug and siRNA, we have developed a time-dependent sequential drug delivery system (DDS) based on a disulfide-linked chitosan-based nanocarrier (CS-ss-SA) for the co-delivery of paclitaxel (PTX) and Bcl-2 specific siRNA (siBcl-2). This CS-ss-SA nanocarrier is able to transport both drug and siRNA by entrapment of PTX and adsorption of siRNA on the shell by electrostatic attraction...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27818904/lanthanide-doped-upconversion-nanoparticles-emerging-intelligent-light-activated-drug-delivery-systems
#7
Ali Bagheri, Hamidreza Arandiyan, Cyrille Boyer, May Lim
The development of drug delivery systems (DDSs) using near infrared (NIR) light and upconversion nanoparticles (UCNPs) has generated intensive interest over the past five years. These NIR-initiated DDSs not only offer a high degree of spatial and temporal determination of therapeutic release but also provide precise control over the released dosage. Furthermore, these nanoplatforms confer several advantages over conventional light-based DDSs-NIR offers better tissue penetration depth and a reduced risk of cellular photo-damage caused by exposure to light at high-energy wavelengths (e...
July 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27803485/development-of-a-multi-functional-nano-device-for-safe-and-effective-gene-delivery-to-target-organs
#8
Yukinobu Kodama
 Nucleic acids are expected as novel effective medicines, although they require a drug delivery system (DDS). Complexes of nucleic acids with cationic liposomes and cationic polymers have been mainly used as DDS for clinical use. However, most cationic complexes have disadvantages such as strong cytotoxicity and low biocompatibility. We previously found that a plasmid DNA (pDNA) complex coated with biodegradable γ-polyglutamic acid (γ-PGA) provided adequate gene expression without cytotoxicity. Based on these results, we developed a new DDS (multi-functional Nano-device) of pDNA using biodegradable polyamino acids...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27793129/a-hybrid-concept-analysis-of-children-of-concern-japanese-healthcare-professionals-views-of-children-at-a-high-risk-of-developmental-disability
#9
Ayako Ide-Okochi, Etsuko Tadaka
BACKGROUND: The new Diagnostic and Statistical Manual of Mental Disorders (fifth edition, DSM-5) redefined the boundaries of autism as a spectrum. It has been reported that the number of schoolchildren with undiagnosed developmental disorders (DDs) has risen in Japan. Such children referred to as kininaru-kodomo (KK, "children of concern") by healthcare professionals fall into a gray area. Therefore, KK are often overlooked at infant medical checkups. This leaves KK without necessary medical care and special needs education...
October 28, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27792423/the-world-of-edward-hartley-angle-md-dds
#10
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Angle Orthodontist
https://www.readbyqxmd.com/read/27772725/hierarchical-self-assembly-of-heparin-peg-end-capped-porous-silica-as-a-redox-sensitive-nanocarrier-for-doxorubicin-delivery
#11
Thu Thao Nguyen Thi, Tuong Vi Tran, Ngoc Quyen Tran, Cuu Khoa Nguyen, Dai Hai Nguyen
Porous nanosilica (PNS) has been attracting a great attention in fabrication carriers for drug delivery system (DDS). However, unmodified PNS-based carriers exhibited the initial burst release of loaded bioactive molecules, which may limit their potential clinical application. In this study, the surface of PNS was conjugated with adamantylamine (A) via disulfide bonds (PNS-SS-A) which was functionalized with cyclodextrin-heparin-polyethylene glycol (CD-HPEG) for redox triggered doxorubicin (DOX) delivery. The modified PNS was successfully formed with spherical shape and diameter around 50nm determined by transmission electron microscopy (TEM)...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27771486/delivery-system-for-berberine-chloride-based-on-the-nanocarrier-znal-layered-double-hydroxide-physicochemical-characterization-release-behavior-and-evaluation-of-anti-bacterial-potential
#12
Mohamed Amine Djebbi, Alae Elabed, Zaineb Bouaziz, Moulay Sadiki, Soumya Elabed, Philippe Namour, Nicole Jaffrezic-Renault, Abdesslem Ben Haj Amara
Layered double hydroxide (LDH) has attracted major interest as one of the most versatile drug delivery systems especially for adsorption capacity and/or controlled delivery property of bioactive agents owing to their combining features of biohybrid. ZnAl synthesized layered double hydroxide can offer a platform to immobilize various types of bioactive compounds, particularly berberine chloride (BBC). However, the immobilization reaction of berberine chloride into ZnAl-LDH was performed by direct co-precipitation method at different ratios of BBC/LDH...
October 19, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27761641/impulse-control-behaviors-and-subthalamic-deep-brain-stimulation-in-parkinson-disease
#13
Aristide Merola, Alberto Romagnolo, Laura Rizzi, Mario Giorgio Rizzone, Maurizio Zibetti, Michele Lanotte, George Mandybur, Andrew P Duker, Alberto J Espay, Leonardo Lopiano
To determine the clinical and demographic correlates of persistent, remitting, and new-onset impulse control behaviors (ICBs) before and after subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We compared the pre- and post-surgical prevalence of ICBs, classified as impulse control disorders (ICD), dopamine dysregulation syndrome (DDS), and punding in 150 consecutive PD STN-DBS-treated patients and determined the association with motor, cognitive, neuropsychological, and neuropsychiatric endpoints...
October 19, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27759822/clinical-and-sociodemographic-variables-associated-with-diabetes-related-distress-in-patients-with-type-2-diabetes-mellitus
#14
Flávia Cristina Zanchetta, Danilo Donizetti Trevisan, Priscila Peruzzo Apolinario, Juliana Bastoni da Silva, Maria Helena de Melo Lima
Objective: To evaluate the relation between diabetes-related distress and the clinical and sociodemographic characteristics of type 2 diabetes mellitus patients. Methods: A cross-sectional study based on a secondary analysis of data collected at a specialized care outpatient center in Brazil. Participants completed a questionnaire on sociodemographic and clinical characteristics and the Brazilian version of the Diabetes Distress Scale (B-DDS). Results: About 31% of the 130 eligible patients reported diabetes distress, and the mean B-DDS score was 2...
July 2016: Einstein
https://www.readbyqxmd.com/read/27759628/steroid-sparing-effect-and-toxicity-of-dapsone-treatment-in-giant-cell-arteritis-a-single-center-retrospective-study-of-70-patients
#15
Kim Heang Ly, François Dalmay, Guillaume Gondran, Sylvain Palat, Holy Bezanahary, Anne Cypierre, Anne-Laure Fauchais, Eric Liozon
Although a glucocorticoid (GC)-sparing strategy is needed for patients with giant cell arteritis (GCA) suffering from refractory disease or serious treatment-related complications, evidence of efficacy in this setting of immunosuppressive drugs and biotherapies is lacking. Herein, we evaluated the GC-sparing effects and tolerability of addition of dapsone (DDS) to prednisone therapy in patients with GCA. We retrospectively assessed data on 18 GCA patients who received DDS as a first-line treatment (DDS-1 group) and 52 patients who received it as a second- or third-line treatment for refractory GCA, with or without excessive GC-related toxicity (DDS-2 group)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27756683/localization-of-dexamethasone-within-dendritic-core-multishell-cms-nanoparticles-and-skin-penetration-properties-studied-by-multi-frequency-electron-paramagnetic-resonance-spectroscopy-epr
#16
S Saeidpour, S B Lohan, M Anske, M Unbehauen, E Fleige, R Haag, M C Meinke, R Bittl, C Teutloff
The skin and especially the stratum corneum (SC) act as a barrier and protect epidermal cells and thus the whole body against xenobiotica of the external environment. Topical skin treatment requires an efficient drug delivery system (DDS). Polymer-based nanocarriers represent novel transport vehicles for dermal application of drugs. In this study dendritic core-multishell (CMS) nanoparticles were investigated as promising candidates. CMS were loaded with a drug (analogue) and were applied to penetration studies of skin...
October 15, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27754672/photocaging-of-single-and-dual-similar-or-different-carboxylic-and-amino-acids-by-acetyl-carbazole-and-its-application-as-dual-drug-delivery-in-cancer-therapy
#17
Yarra Venkatesh, Yetirajam Rajesh, Sambath Karthik, Chetan Anabur C, Mahitosh Mandal, Avijit Jana, N D Pradeep Singh
A new fluorescent photoremovable protecting group (FPRPG) based on acetylcarbazole framework has been explored for the first time release of single and dual (similar or different) substrates from single chromophore. Mechanistic studies of the photorelease process revealed that photorelease of two (similar or different) substrates from acetyl carbazole proceeds via a stepwise pathway. Further, we constructed photoresponsive dual drug delivery system (DDS) to release of two different anticancer drugs (Caffeic acid and Chlorambucil 1 equivalent each)...
October 18, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27747544/texting-while-driving-the-development-and-validation-of-the-distracted-driving-survey-and-risk-score-among-young-adults
#18
Regan W Bergmark, Emily Gliklich, Rong Guo, Richard E Gliklich
BACKGROUND: Texting while driving and other cell-phone reading and writing activities are high-risk activities associated with motor vehicle collisions and mortality. This paper describes the development and preliminary evaluation of the Distracted Driving Survey (DDS) and score. METHODS: Survey questions were developed by a research team using semi-structured interviews, pilot-tested, and evaluated in young drivers for validity and reliability. Questions focused on texting while driving and use of email, social media, and maps on cellular phones with specific questions about the driving speeds at which these activities are performed...
December 2016: Injury Epidemiology
https://www.readbyqxmd.com/read/27745698/in%C3%A2-vitro-release-mechanisms-of-doxorubicin-from-a-clinical-bead-drug-delivery-system
#19
Emelie Ahnfelt, Erik Sjögren, Per Hansson, Hans Lennernäs
The release rate of doxorubicin (DOX) from the drug-delivery system (DDS), DC Bead, was studied by 2 miniaturized in vitro methods: free-flowing and sample reservoir. The dependencies of the release mechanisms on in vitro system conditions were investigated experimentally and by theoretical modeling. An inverse relationship was found between release rates and bead size, most likely due to the greater total surface area. The release rates correlated positively with temperature, release medium volume, and buffer strength, although the release medium volume had larger effect than the buffer strength...
September 20, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27733520/on-farm-crop-species-richness-is-associated-with-household-diet-diversity-and-quality-in-subsistence-and-market-oriented-farming-households-in-malawi
#20
Andrew D Jones
BACKGROUND: On-farm crop species richness (CSR) may be important for maintaining the diversity and quality of diets of smallholder farming households. OBJECTIVES: The objectives of this study were to 1) determine the association of CSR with the diversity and quality of household diets in Malawi and 2) assess hypothesized mechanisms for this association via both subsistence- and market-oriented pathways. METHODS: Longitudinal data were assessed from nationally representative household surveys in Malawi between 2010 and 2013 (n = 3000 households)...
October 12, 2016: Journal of Nutrition
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