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https://www.readbyqxmd.com/read/29330334/detection-of-heterozygous-mutation-in-hook-microtubule-tethering-protein-1-in-three-patients-with-decapitated-and-decaudated-spermatozoa-syndrome
#1
Huixing Chen, Yong Zhu, Zijue Zhu, Erlei Zhi, Keming Lu, Xiaobo Wang, Feng Liu, Zheng Li, Weiliang Xia
BACKGROUND: The mechanism of intramanchette transport is crucial to the transformation of sperm tail and the nuclear condensation during spermiogenesis. Although few dysfunctional proteins could result in abnormal junction between the head and tail of spermatozoon, little is known about the genetic cues in this process. OBJECTIVE: Based on patients with severe decapitated and decaudated spermatozoa (DDS) syndrome, the study aimed to validate whether new mutation exists on their Hook microtubule-tethering protein 1 (HOOK1) genes and follow their results of assisted reproduction treatment (ART)...
January 12, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29328868/oral-sciences-phd-program-enrollment-graduates-and-placement-1994-to-2016
#2
C R Herzog, D W Berzins, P DenBesten, R L Gregory, K M Hargreaves, R L W Messer, M Mina, M P Mooney, M L Paine, C Phillips, R B Presland, R G Quivey, F A Scannapieco, J F Sheridan, K K H Svoboda, P C Trackman, M P Walker, S G Walker, C Y Wang, J C C Hu
For decades, dental schools in the United States have endured a significant faculty shortage. Studies have determined that the top 2 sources of dental faculty are advanced education programs and private practice. Those who have completed both DDS and PhD training are considered prime candidates for dental faculty positions. However, there is no national database to track those trainees and no evidence to indicate that they entered academia upon graduation. The objective of this study was to assess outcomes of dental school-affiliated oral sciences PhD program enrollment, graduates, and placement between 1994 and 2016...
January 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29326967/hr-tem-and-ft-raman-dataset-of-the-caffeine-interacted-phe-phe-peptide-nanotube-for-possible-sensing-applications
#3
A Lakshmi Narayanan, M Dhamodaran, J Samu Solomon, B Karthikeyan, R Govindhan
Sensing ability of caffeine interaction with Phe-Phe annotates (PNTs), is presented (Govindhan et al., 2017; Karthikeyan et al., 2014; Tavagnacco et al., 2013; Kennedy et al., 2011; Wang et al., 2017) [1-5] in this data set. Investigation of synthesized caffeine carrying peptide nanotubes are carried out by FT-Raman spectral analysis and high resolution transmission electron microscopy (HR-TEM). Particle size of the caffeine loaded PNTs is < 40 nm. The FT-Raman spectrum signals are enhanced in the region of 400-1700 cm-1...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29301728/prevalence-and-determinants-of-diabetes-distress-in-patients-of-diabetes-mellitus-in-a-tertiary-care-centre
#4
Deepak Gahlan, Rajesh Rajput, Pratibha Gehlawat, Rajiv Gupta
BACKGROUND: Patients of diabetes mellitus experience psychological difficulties associated with their disease which remains unrecognized involving several states related to coping with diabetes. Diabetes distress is a distinct condition which is often mistaken for depression and is related to adverse disease outcomes. AIMS AND OBJECTIVE: To study the prevalence and predictors of diabetes distress in patients of Type 2 Diabetes mellitus (T2DM) in a tertiary care centre...
December 22, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29301050/field-detection-of-drugs-of-abuse-in-oral-fluid-using-the-alere%C3%A2-dds%C3%A2-2-mobile-test-system-with-confirmation-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#5
Alex J Krotulski, Amanda L A Mohr, Melissa Friscia, Barry K Logan
The collection and analysis of drugs in oral fluid (OF) at the roadside has become more feasible with the introduction of portable testing devices such as the Alere™ DDS®2 Mobile Test System (DDS®2). The objective of this study was to compare the on-site results for the DDS®2 to laboratory-based confirmatory assays with respect to detection of drugs of abuse in human subjects. As part of a larger Institutional Review Board approved study, two OF samples were collected from each participant at a music festival in Miami, FL, USA...
December 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29295927/novel-concept-of-the-smart-nir-light-controlled-drug-release-of-black-phosphorus-nanostructure-for-cancer-therapy
#6
Meng Qiu, Dou Wang, Weiyuan Liang, Liping Liu, Yin Zhang, Xing Chen, David Kipkemoi Sang, Chenyang Xing, Zhongjun Li, Biqin Dong, Feng Xing, Dianyuan Fan, Shiyun Bao, Han Zhang, Yihai Cao
A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29295027/intimate-partner-violence-among-patients-with-dissociative-disorders
#7
Aliya R Webermann, Bethany L Brand, Shaina A Kumar
Childhood trauma is common among survivors and perpetrators of intimate partner violence (IPV). Although symptoms of posttraumatic stress disorder (PTSD) and dissociative disorders (DDs) are predictors of IPV victimization and perpetration, few studies explore IPV among those with DDs. The present study examined IPV and symptoms as predictors among participants in the Treatment of Patients With Dissociative Disorders (TOP DD) Network study, an educational intervention for individuals with DDs and their clinicians...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288856/risk-factors-and-management-of-dural-defects-in-anterior-surgery-for-cervical-ossification-of-the-posterior-longitudinal-ligament
#8
Yue-Qi Du, Wan-Ru Duan, Zan Chen, Hao Wu, Feng-Zeng Jian
OBJECTIVE: To investigate risk factors and outcomes and to develop a cogent perioperative management algorithm for dural defects (DDs) in anterior surgery for cervical ossification of the posterior longitudinal ligament (OPLL). METHODS: Ninety OPLL patients underwent anterior cervical decompression between January 2014 and December 2016 were reviewed. DDs occurred in 12 patients. Demographic, clinical and radiological data; intra- and postoperative management; and complications were analyzed...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29277182/-application-of-digital-drainage-system-in-postoperative-refractory-prolonged-air-leaks-after-pulmonary-surgery
#9
Donglai Chen, Xiermaimaiti Kadeer, Zhe Shi, Yuxing Jin, Chang Chen
BACKGROUND: Postoperative prolonged air leaks is one of the most common complications secondary to pulmonary resections. Digital drainage system (DDS) is considered as an accurate and objective device which has been found to be comfortable and well tolerated by patients, economical as well. The aim of this study is to explore the application of DDS in patients with postoperative refractory prolonged air leaks after pulmonary surgery. METHODS: Prolonged air leak (PAL) is defined as air leaks lasting for more than 5 d after video-assisted surgery or more than 7 d after thoracotomy...
December 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29274951/correlation-between-the-posterior-mandibular-width-and-the-lingual-gap-caused-by-symphyseal-fractures-using-a-virtual-model
#10
Christian Pedemonte Trewhela, Andrea Carmona Avendaño, Edgardo González Mora, Ilich Vargas Farren, Francisco Lopetegui Caceres, Erick Rojas Quiroz
PURPOSE: The objective was to determine the dimensional impact, on the occlusal and articular level, of the gap produced in the lingual plate from symphyseal fractures, correlated with the dimensional change in the posterior mandibular width. MATERIALS AND METHODS: We performed an observational experimental study based on 30 computed tomography scans of patients treated by the Maxillofacial Surgery Service, Hospital Clínico Mutual de Seguridad, Santiago, Chile, between 2012 and 2016...
December 7, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29273816/novel-mealtime-duration-measures-reliability-and-preliminary-associations-with-clinical-feeding-and-swallowing-performance-in-self-feeding-children-with-cerebral-palsy
#11
Avinash Mishra, Justine J Sheppard, Cagla Kantarcigil, Andrew M Gordon, Georgia A Malandraki
Purpose: The purpose of this study is to examine (a) the reliability of newly developed measures of mealtime duration and (b) their relationship to clinical feeding/swallowing performance in children with spastic cerebral palsy (SCP). Method: Seventeen self-feeding children (9 boys, 8 girls) with SCP (age range = 5;1 [years;months] to 17;6, Gross Motor Function Classification System range = I-IV) were assessed during mealtimes using the Dysphagia Disorder Survey (DDS; Sheppard, Hochman, & Baer, 2014)...
December 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29248558/curcumin-lipoic-acid-conjugate-as-a-promising-anticancer-agent-on-the-surface-of-gold%C3%A2-iron-oxide-nanocomposites-a-ph-sensitive-targeted-drug-delivery-system-for-brain-cancer-theranostics
#12
Milad Ghorbani, Bahareh Bigdeli, Leili Jalili-Baleh, Hadi Baharifar, Mohammad Akrami, Sadegh Dehghani, Bahram Goliaei, Amir Amani, Alireza Lotfabadi, Hamid Rashedi, Ismaeil Haririan, Nader Riyahi Alam, Morteza Pirali Hamedani, Mehdi Khoobi
Brain tumor is a lethal, fast growing cancer and a difficult case for treatment. Receptor-mediated endocytosis has been recognized as one of the most effective methods for drug delivery to brain tissue by overcoming obstacles associated with conventional therapeutics. In this work, a targeted theranostic drug delivery system (DDS) was prepared based on gold‑iron oxide nanocomposites (Fe3O4@Au NCs). Lipoic acid-curcumin (LA-CUR) was synthesized and introduced as a novel anticancer drug, and glutathione (GSH) was exploited as the targeting ligand...
December 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29246372/john-i-ingle-dds-msd-1919-2017-the-legacy-of-an-extraordinary-leader
#13
Leif K Bakland, Ilan Rotstein
No abstract text is available yet for this article.
January 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29217502/the-impact-of-a-mobile-diabetes-health-intervention-on-diabetes-distress-and-depression-among-adults-secondary-analysis-of-a-cluster-randomized-controlled-trial
#14
Charlene C Quinn, Krystal K Swasey, J Christopher F Crabbe, Michelle D Shardell, Michael L Terrin, Erik A Barr, Ann L Gruber-Baldini
BACKGROUND: Diabetes is a complex, demanding disease that requires the constant attention of patients. The burden of self-management, including different medication regimens, routine self-care activities, and provider visits, has an impact on patients' emotional well-being. Diabetes distress and depression are two important components of emotional well-being that may negatively affect diabetes outcomes. OBJECTIVE: The aim was to determine the impact of the 1-year Mobile Diabetes Intervention Study cluster randomized clinical trial on emotional well-being measured by diabetes distress and depression among adults with type 2 diabetes (T2D)...
December 7, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29215573/the-use-of-liposomes-and-nanoparticles-as-drug-delivery-systems-to-improve-cancer-treatment-in-dogs-and-cats
#15
REVIEW
Katarzyna Zabielska-Koczywąs, Roman Lechowski
BACKGROUND: Cancer remains a leading cause of death in companion animals. In human medicine, liposomes and nanoparticles have been extensively investigated as drug delivery systems (DDS) for anticancer agents due to their ability to target cancerous cells and reduce the negative side effects of free cytostatic drugs. In this review, the authors discuss the results of clinical trials using liposomes and polymer-based nanoparticles as DDS to improve cancer treatment in dogs and cats, indicating which ones seem worth further evaluation...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29214897/ss-31-peptide-enables-mitochondrial-targeting-drug-delivery-a-promising-therapeutic-alteration-to-prevent-hair-cell-damage-from-aminoglycosides
#16
Xiao Kuang, Shuang Zhou, Weiling Guo, Zhenjie Wang, Yanhui Sun, Hongzhuo Liu
Aminoglycoside-induced hearing loss stems from damage or loss of mechanosensory hair cells in the inner ear. Intrinsic mitochondrial cell death pathway plays a key role in that cellular dysfunction for which no proven effective therapies against oto-toxicities exist. Therefore, the aim of the present study was to develop a new mitochondrial targeting drug delivery system (DDS) that provided improved protection from gentamicin. Particularly, SS-31 peptide-conjugated geranylgeranylacetone (GGA) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles were constructed successfully via emulsion-solvent evaporation method...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29209462/dietary-intakes-of-adolescents-from-food-insecure-households-analysis-of-data-from-the-6th-2013-2015-korea-national-health-and-nutrition-examination-survey
#17
Mariam Nakitto, Kana Asano, Injoo Choi, Jihyun Yoon
BACKGROUND/OBJECTIVES: This study aimed at evaluating the dietary intakes of Korean adolescents affected by food insecurity, in comparison with those who were food secure. SUBJECTS/METHODS: The study used one day 24-hour dietary recall data from the 6th Korea National Health and Nutrition Examination Survey. The study subjects consisted of 1,453 adolescents of whom 695 were middle school-aged and 758 were high school-aged. Food security status was assessed using the 18-item questionnaire...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29208373/roles-of-maternal-wnt8a-transcripts-in-axis-formation-in-zebrafish
#18
Hiromu Hino, Akiko Nakanishi, Ryoko Seki, Tsubasa Aoki, Etsuro Yamaha, Atsuo Kawahara, Takashi Shimizu, Masahiko Hibi
In early zebrafish development, the program for dorsal axis formation begins soon after fertilization. Previous studies suggested that dorsal determinants (DDs) localize to the vegetal pole, and are transported to the dorsal blastomeres in a microtubule-dependent manner. The DDs activate the canonical Wnt pathway and induce dorsal-specific genes that are required for dorsal axis formation. Among wnt-family genes, only the wnt8a mRNA is reported to localize to the vegetal pole in oocytes and to induce the dorsal axis, suggesting that Wnt8a is a candidate DD...
December 2, 2017: Developmental Biology
https://www.readbyqxmd.com/read/29208069/the-delirium-drug-scale-is-associated-to-delirium-incidence-in-the-emergency-department
#19
Patrick Viet-Quoc Nguyen, Lucie Pelletier, Isabelle Payot, Judith Latour
BACKGROUND: The Delirium Drug Scale (DDS) is an evaluation scale developed to assess a patient's drug burden for delirium. The primary goal is to validate the association between the DDS score and the incidence of delirium. METHODS: This study was an observational retrospective cross-sectional chart review study in patients aged 75 years and older. It was carried out in three emergency departments of a tertiary care university health center. Patients were included if a medication list was available...
December 6, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29208001/factors-associated-with-infants-and-young-children-s-6-23%C3%A2-months-dietary-diversity-in-pakistan-evidence-from-the-demographic-and-health-survey-2012-13
#20
Sarosh Iqbal, Rubeena Zakar, Muhammad Zakria Zakar, Florian Fischer
BACKGROUND: Optimum nutrition and good feeding practices amongst infants and young children are the key determinants of growth for a healthy life. Dietary diversity is considered to be a reliable and easy-to-measure proxy variable to assess young children's feeding practices for dietary adequacy and nutritional intake. This research aims to examine the current practices of dietary diversity amongst infants and young children aged 6-23 months in Pakistan and the various associated factors at child, maternal, household and community levels...
December 6, 2017: Nutrition Journal
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