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https://www.readbyqxmd.com/read/28416142/nanoparticle-mediated-drug-delivery-system-for-atherosclerotic-cardiovascular-disease
#1
REVIEW
Tetsuya Matoba, Jun-Ichiro Koga, Kaku Nakano, Kensuke Egashira, Hiroyuki Tsutsui
Administration of drugs and other therapeutic agents has been the central strategy of contemporary medicine for cardiovascular disease. The use of drug delivery systems (DDS) includes micelles, liposomes, polymeric nanoparticles, dendrimers, carbon nanotubes, and crystalline metals. Nano-DDS modify in vivo drug kinetics, depending on (patho)physiological mechanisms such as retard excretion, vascular permeability, and incorporation by mononuclear phagocyte systems, which constitute the 'passive-targeting' property of nano-DDS...
April 13, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28411068/protective-effect-of-dapsone-on-cognitive-impairment-induced-by-propofol-involves-hippocampal-autophagy
#2
Ning Yang, Lunxu Li, Zhengqian Li, Cheng Ni, Yiyun Cao, Taotao Liu, Miao Tian, Dehua Chui, Xiangyang Guo
Post-operative cognitive dysfunction (POCD) is a commonly seen postoperative complication in elderly patients and its underlying mechanisms are still unclear. Autophagy, a degradation mechanism of cellular components, is required for cell survival and many physiological processes. Although propofol is one of the most commonly used intravenous anesthetics, investigations into its mechanisms and effects on cognition in aged rodents are relatively scarce. In this study, we evaluate the influence of propofol on learning and memory, and identify the potential role of hippocampal autophagy in propofol-induced cognitive alterations in aged rats...
April 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28409034/increased-intracranial-pressure-during-hemodialysis-in-a-patient-with-anoxic-brain-injury
#3
Anton Lund, Mette B Damholt, Ditte G Strange, Jesper Kelsen, Hasse Møller-Sørensen, Kirsten Møller
Dialysis disequilibrium syndrome (DDS) is a serious neurological complication of hemodialysis, and patients with acute brain injury are at increased risk. We report a case of DDS leading to intracranial hypertension in a patient with anoxic brain injury and discuss the subsequent dialysis strategy. A 13-year-old girl was admitted after prolonged resuscitation from cardiac arrest. Computed tomography (CT) revealed an inferior vena cava aneurysm and multiple pulmonary emboli as the likely cause. An intracranial pressure (ICP) monitor was inserted, and, on day 3, continuous renal replacement therapy (CRRT) was initiated due to acute kidney injury, during which the patient developed severe intracranial hypertension...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28408201/spatio-temporal-control-strategy-of-drug-delivery-systems-based-nano-structures
#4
REVIEW
Nahla Rahoui, Bo Jiang, Nadia Taloub, Yu Dong Huang
The drug instability, toxicity and the barrier to the target area necessitate a suitable drug delivery system with an external or internal control of the release. Spatio-temporal control using a surface functionalized nano-carrier seems to be the best alternative for guided drug delivery and release. This manuscript provides a broad spectrum about the drug carrier interface modification to cover the need for temporal drug delivery control under neglect side effects. On the other hand, recent advances related to the drug vehicle are highlighted, besides physical (Electric field, magnetic field, light) or mechanical (Ultrasound, mechanical strain), chemical (pH, redox gradient, enzyme) stimuli mediated DDS...
April 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28401023/biopolymer-based-nanosystem-for-doxorubicin-targeted-delivery
#5
Zsuzsanna Csikós, Krisztina Kerekes, Erika Fazekas, Sándor Kun, János Borbély
This study describes formation of an actively and passively targeted, water-soluble drug delivery system (DDS) which contains doxorubicin (DOX). The system comprises two biocompatible and biodegradable polymers: poly-γ-glutamic acid (PGA) and chitosan (CH). Self-assembly of these biopolymers in aqueous medium results stable nanoparticles (NPs) with a hydrodynamic size of 80-150 nm and slightly negative surface charge. Folic acid (FA) was used as targeting agent bonded to the polyanion (PA) and also to the surface of the NPs...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28392304/morphological-dendritic-spine-changes-of-medium-spiny-neurons-in-the-nucleus-accumbens-in-6-hydroxydopamine-lesioned-rats-treated-with-levodopa
#6
Yukihisa Funamizu, Haruo Nishijima, Tatsuya Ueno, Shinya Ueno, Hiroki Mizukami, Soroku Yagihashi, Masahiko Tomiyama
The mechanisms of dopamine dysregulation syndrome (DDS) in Parkinson's disease (PD) remain unclear, although it is known that the nucleus accumbens (NAc) plays a role in its development. Based on the hypothesis that DDS and levodopa-induced dyskinesia (LID) share a pathophysiological basis, we investigated dendritic spine morphology of medium spiny neurons (MSNs) in the NAc of a rat model of LID, because spine enlargement in MSNs of the caudate/putamen has been proposed to be a morphological hallmark of LID...
April 6, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28389582/the-impact-of-continuous-glucose-monitoring-on-markers-of-quality-of-life-in-adults-with-type-1-diabetes-further-findings-from-the-diamond-randomized-clinical-trial
#7
William H Polonsky, Danielle Hessler, Katrina J Ruedy, Roy W Beck
OBJECTIVE: Continuous glucose monitoring (CGM) improves glycemic control, but data are inconclusive about its influence on quality of life (QOL). We investigated the impact of 24 weeks of CGM use on QOL in adults with type 1 diabetes (T1D) who use multiple daily insulin injections. RESEARCH DESIGN AND METHODS: DIAMOND was a prospective randomized trial that assessed CGM versus self-monitoring of blood glucose (SMBG) only in 158 adults with poorly controlled T1D...
April 7, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28376921/the-effectiveness-of-a-value-based-emotion-cognition-focused-educational-programme-to-reduce-diabetes-related-distress-in-malay-adults-with-type-2-diabetes-vemofit-study-protocol-for-a-cluster-randomised-controlled-trial
#8
Boon-How Chew, Rimke C Vos, Sazlina Shariff Ghazali, Nurainul Hana Shamsuddin, Aaron Fernandez, Firdaus Mukhtar, Mastura Ismail, Azainorsuzila Mohd Ahad, Narayanan N Sundram, Siti Zubaidah Mohd Ali, Guy E H M Rutten
BACKGROUND: Type 2 diabetes mellitus (T2DM) patients experience many psychosocial problems related to their diabetes. These often lead to emotional disorders such as distress, stress, anxiety and depression, resulting in decreased self-care, quality of life and disease control. The purpose of the current study is to evaluate the effectiveness of a brief value-based emotion-focused educational programme in adults with T2DM on diabetes-related distress (DRD), depressive symptoms, illness perceptions, quality of life, diabetes self-efficacy, self-care and clinical outcomes...
April 4, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28372419/precisely-synchronous-and-cascadable-multi-channel-arbitrary-waveform-generator
#9
Ke Liu, Shulin Tian, Guangkun Guo, Yindong Xiao
The output bandwidth and the capability to generate multiple analog outputs with accurately adjustable relative phase are important specifications of arbitrary waveform generator (AWG). To increase the output bandwidth, AWG with a multi-memory paralleled direct digital synthesizer structure (DDS) was proposed to break through operating speed limitations of memory and field programmable gate array. But this structure does complicate synchronization of the analog outputs. This paper proposes a structure for synchronization of the outputs of multi-channel high speed AWG that generates arbitrary waveforms using a multi-memory paralleled DDS...
March 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28365602/benefits-of-case-based-versus-traditional-lecture-based-instruction-in-a-preclinical-removable-prosthodontics-course
#10
David B Samuelson, Kimon Divaris, Ingeborg J De Kok
This study compared the acceptability and relative effectiveness of case-based learning (CBL) versus traditional lecture-based (LB) instruction in a preclinical removable prosthodontics course in the University of North Carolina at Chapel Hill School of Dentistry DDS curriculum. The entire second-year class (N=82) comprised this crossover study's sample. Assessments of baseline comprehension and confidence in removable partial denture (RPD) treatment planning were conducted at the beginning of the course. Near the end of the course, half of the class received CBL and LB instruction in an RPD module in alternating sequence, with students serving as their own control group...
April 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28364948/adoption-of-dental-innovations-the-case-of-a-standardized-dental-diagnostic-terminology
#11
Rachel B Ramoni, Jini Etolue, Oluwabunmi Tokede, Lyle McClellan, Kristen Simmons, Alfa Yansane, Joel M White, Muhammad F Walji, Elsbeth Kalenderian
BACKGROUND: Standardized dental diagnostic terminologies (SDDxTs) were introduced decades ago. Their use has been on the rise, accompanying the adoption of electronic health records (EHRs). One of the most broadly used terminologies is the Dental Diagnostic System (DDS). Our aim was to assess the adoption of SDDxTs by US dental schools by using the Rogers diffusion of innovations framework, focusing on the DDS. METHODS: The authors electronically surveyed clinic deans in all US dental schools (n = 61) to determine use of an EHR and SDDxT, perceived barriers to adoption of an SDDxT, and the effect of implementing an SDDxT on clinical productivity...
March 30, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28355998/bioactive-molecule-loaded-drug-delivery-systems-to-optimize-bone-tissue-repair
#12
João Augusto Oshiro, Mariana Rillo Sato, Cassio Rocha Scardueli, Guilherme José Pimentel Lopes Oliveira, Marina Paiva Abuçafy, Marlus Chorilli
Bioactive molecules such as peptides and proteins can optimize the repair of bone tissue; however, the results are often unpredictable when administered alone, owing to their short biological half-life and instability. Thus, the development of bioactive molecule-loaded drug delivery systems (DDS) to repair bone tissue has been the subject of intense research. DDS can optimize the repair of bone tissue owing to their physicochemical properties, which improve cellular interactions and enable the incorporation and prolonged release of bioactive molecules...
March 28, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28351757/nanotechnological-strategies-for-nerve-growth-factor-delivery-therapeutic-implications-in-alzheimer-s-disease
#13
REVIEW
Célia Faustino, Patrícia Rijo, Catarina Pinto Reis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with amyloid-β peptide misfolding and aggregation. Neurotrophic factors, such as nerve growth factor (NGF), can prevent neuronal damage and rescue the cholinergic neurons that undergo cell death in AD, reverse deposition of extracellular amyloid plaques and improve cognitive deficits. However, NGF administration is hampered by the poor pharmacokinetic profile of the therapeutic protein and its inability to cross the blood-brain barrier, which requires specialised drug delivery systems (DDS) for efficient NGF delivery to the brain...
March 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28349741/organochlorine-pesticides-ocps-in-raft-mussels-coming-from-galician-r%C3%A3-as
#14
Nieves Carro, Isabel García, María Ignacio, Ana Mouteira
This survey gives an overview of the range of organochlorine pesticides (OCPs) α and γ-HCH (lindane), HCB, pp´-DDE, pp´-DDD, op´-DDT, pp´-DDT, aldrin, dieldrin, endrin, isodrin and trans-nonachlor in raft mussels cultivated in several polygons of the Galician Rías (Ares-Betanzos, Muros-Noia, Arousa, Pontevedra and Vigo) during the period 1998-2014. A significant number of OCPs were detected but the levels found were generally low, mainly in the recent samplings (2010-2014). The levels of ∑DDs (sum of DDTs and its metabolites, pp´-DDE and pp´-DDD) ranged between 0...
March 28, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28328176/glucose-responsive-supramolecular-vesicles-based-on-water-soluble-pillar-5-arene-and-pyridylboronic-acid-derivatives-for-controlled-insulin-delivery
#15
Lei Gao, Tingting Wang, Keke Jia, Xuan Wu, Chenhao Yao, Wei Shao, Dongmei Zhang, Xiao-Yu Hu, Leyong Wang
The stimuli-responsive behavior of supramolecular nanocarriers is crucial for their potential applications as smart drug delivery systems. We hereby constructed a glucose-responsive supramolecular drug delivery system based on the host-guest interaction between a water-soluble pillar[5]arene (WP5) and a pyridylboronic acid derivative (G) for insulin delivery and controlled release under physiological conditions. The approach represents the ideal treatment of diabetes mellitus. The drug loading and in vitro drug release experiments demonstrated that large molecular weight insulin could be encapsulated into the vesicles with high loading efficiency, which, to our knowledge, is the first example of small-size supramolecular vesicles with excellent encapsulation capacity of a large protein molecule...
March 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28319001/impact-on-psychosocial-outcomes-of-a-nationally-available-weight-management-program-tailored-for-individuals-with-type-2-diabetes-results-of-a-randomized-controlled-trial
#16
Lauren Holland-Carter, Peter W Tuerk, Thomas A Wadden, Ken N Fujioka, Lynne E Becker, Karen Miller-Kovach, Priscilla L Hollander, W Timothy Garvey, Daniel Weiss, Domenica M Rubino, Robert F Kushner, Robert J Malcolm, William J Raum, Kathie L Hermayer, Jan L Veliko, Stephanie L Rost, Nicoleta D Sora, Jonny L Salyer, Patrick M O'Neil
AIMS: Type 2 diabetes mellitus (T2DM) can substantially decrease quality of life (QOL). This study examined the effects on QOL-relevant psychosocial measures of a widely available commercial weight loss program enhanced for individuals with T2DM. METHODS: A year-long multi-site randomized clinical trial compared the Weight Watchers (WW) approach, supplemented with phone and email counseling with a certified diabetes educator (CDE), to brief standard diabetes nutrition counseling and education (Standard Care; SC)...
February 16, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28318938/diabetes-nurse-case-management-in-a-canadian-tertiary-care-setting-results-of-a-randomized-controlled-trial
#17
Danni Li, Tom Elliott, Gerri Klein, Ehud Ur, Tricia S Tang
OBJECTIVES: To examine the effects of a 6-month nurse case manager (NCM) intervention compared to standard care (SC) on glycemic control and diabetes distress in a Canadian tertiary-care setting. METHODS: We recruited 140 adults with type 2 diabetes and glycated hemoglobin (A1C) levels >8% (64 mmol/mol) from 2 tertiary care facilities and randomized them to: 1) a 6-month NCM intervention in addition to SC or 2) SC by the primary endocrinologists. Assessments were conducted at baseline and at 6 months...
March 17, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28318411/predicting-a-dissociative-disorder-from-type-of-childhood-maltreatment-and-abuser-abused-relational-tie
#18
Christa Krüger, Lizelle Fletcher
We investigate the types of childhood maltreatment and abuser-abused relational ties that best predict a dissociative disorder (DD). Psychiatric inpatients (n = 116; mean age = 35; F:M = 1.28:1) completed measures of dissociation and trauma. Abuse type and abuser-abused relational ties were recorded in the Traumatic Experiences Questionnaire. Multidisciplinary team clinical diagnosis or administration of the SCID-D-R to high dissociators confirmed DD diagnoses. Logit models described the relationships between abuser-abused relational tie and the diagnostic grouping of patients, DD present (n = 16) or DD absent (n = 100)...
February 23, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28303595/single-intra-articular-injection-of-fluvastatin-plga-microspheres-reduces-cartilage-degradation-in-rabbits-with-experimental-osteoarthritis
#19
Norio Goto, Ken Okazaki, Yukio Akasaki, Kohei Ishihara, Koji Murakami, Kiyoshi Koyano, Yasunori Ayukawa, Noriyuki Yasunami, Tomohiro Masuzaki, Yasuharu Nakashima
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme of the mevalonate pathway. The anti-inflammatory effect of statins has been reported in recent years. The present study investigated therapeutic effects of the local administration of statin in osteoarthritis (OA). We assessed clinically used statins and selected fluvastatin for further experimentation, as it showed potent anabolic and anti-catabolic effects on human OA chondrocytes...
March 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28295770/differences-in-depression-treatment-satisfaction-and-injection-behavior-in-adults-with-type-1-diabetes-and-different-degrees-of-lipohypertrophy
#20
Ingvild Hernar, Johannes Haltbakk, Anders Broström
AIMS AND OBJECTIVES: To assess the prevalence of lipohypertrophy, and to compare differences in external, personal, and regimen factors in adults with type 1 diabetes and different degrees of lipohypertrophy. BACKGROUND: Suboptimal insulin injection behavior is associated with lipohypertrophy, which may affect insulin absorption and lead to blood glucose fluctuations. Few, if any studies have investigated how external, personal, and regimen factors differ in people with type 1 diabetes and different degrees of lipohypertrophy...
March 15, 2017: Journal of Clinical Nursing
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