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https://www.readbyqxmd.com/read/28633318/evaluation-of-oral-fluid-as-a-specimen-for-duid
#1
Allison M Veitenheimer, Jarrad R Wagner
Drugged driving has become more prevalent than drunk driving and is quickly gaining national attention due to increased prescription drug abuse and recent cannabis legalization. Unlike alcohol, police officers do not generally have access to approved devices to screen for drugs at the roadside. Onsite drug screening devices do exist and are used in other countries, but have not garnered widespread approval for use in the United States in driving under the influence of drugs (DUID) cases. One reason for this is that the devices are designed to test oral fluid, which is not a commonly accepted specimen for DUID...
June 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28629059/versatile-quarto-stimuli-nanostructure-based-on-trojan-horse-approach-for-cancer-therapy-synthesis-characterization-in-vitro-and-in-vivo-studies
#2
Eleni K Efthimiadou, Eirini Fragogeorgi, Lazaros Palamaris, Theodoros Karampelas, Pavlos Lelovas, George Loudos, Constantin Tamvakopoulos, Nikolaos Kostomitsopoulos, George Kordas
Nanostructured delivery and diagnostic systems that induces specific targeting properties by exploiting the local physicochemical tumour characteristics will be evaluated is the present work. It is well known that cancer cells have specific physicochemical characteristics, which can be taken into consideration for the design of a broad spectrum of drug delivery systems (DDS). Some of those characteristics including the different temperature environment their susceptibility when temperature ranges between 40 and 43°C where cell apoptosis is induced, the intra- and extra-cellular pH which varies from 6...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28625073/the-impact-of-structured-self-monitoring-of-blood-glucose-combined-with-intensive-education-on-hba1c-levels-hospitalizations-and-quality-of-life-parameters-in-insulin-treated-patients-with-diabetes-at-primary-care-in-serbia
#3
Nebojša M Lalić, Katarina Lalić, Aleksandra Jotić, Dejan Stanojević, Dragana Živojinović, Andrija Janićijević, Christopher Parkin
BACKGROUND: We assessed the effect of structured self-monitoring of blood glucose (SMBG), in combination with intensive education, on metabolic control, SMBG frequency, hospitalizations, cardiovascular risk factors, and quality-of-life parameters in patients with insulin-treated diabetes in primary health care settings in Serbia. METHODS: This 6-month, observational, noninterventional study, followed 346 insulin-treated diabetes patients (type 1 diabetes [T1D], n = 57; type 2 diabetes [T2D], n = 289) from 28 primary care centers...
December 1, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28624658/optimisation-of-hpmc-ophthalmic-inserts-with-sustained-release-properties-as-a-carrier-for-thermolabile-therapeutics
#4
Arnout Everaert, Yannick Wouters, Eline Melsbach, Nadia Zakaria, Annick Ludwig, Filip Kiekens, Wim Weyenberg
A methodology was developed and optimised for the preparation of a new drug delivery system (DDS) with sustained release properties to allow ocular protein delivery and to limit destructive production steps during manufacturing. Elevated temperatures, shear forces and an oxidative environment should be avoided in order to prevent denaturation or oxidation of proteins. An aqueous HPMC solution was prepared using heat and casted into small semi-rod-shaped PVC blisters. The polymer solution was allowed to cool down and was partially dehydrated at room temperature...
June 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28623863/linear-immunoglobulin-a-g-bullous-dermatosis-associated-with-ulcerative-colitis
#5
Asuka Onoe, Daisuke Matsuura, Tadashi Terui, Norito Ishii, Takashi Hashimoto, Toyoko Ochiai
Linear immunoglobulin (Ig)A/G bullous dermatosis (LAGBD) is an autoimmune bullous disease characterized by formation of subepidermal blisters and linear deposition of IgA and IgG antibodies along the basement membrane zone (BMZ). The association between linear IgA bullous dermatosis and ulcerative colitis (UC) is well recognized, but reports of UC-associated LAGBD are lacking. We have reported a 24-year-old man suffering from LAGBD associated with UC, which occurred before exacerbations of skin rash. A skin biopsy indicated a subepidermal blister with an infiltration of primarily neutrophils and eosinophils in the dermis...
June 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28601634/synthesis-and-assembly-of-hepatitis-b-virus-envelope-protein-derived-particles-in-escherichia-coli
#6
Hao Li, Keisuke Onbe, Qiushi Liu, Masumi Iijima, Kenji Tatematsu, Masaharu Seno, Hiroko Tada, Shun' Ichi Kuroda
Hepatitis B virus (HBV) envelope particles have been synthesized in eukaryotic cells (e.g., mammalian cells, insect cells, and yeast cells) as an HB vaccine immunogen and drug delivery system (DDS) nanocarrier. Many researchers had made attempts to synthesize the particles in Escherichia coli for minimize the cost and time for producing HBV envelope particles, but the protein was too deleterious to be synthesized in E. coli. In this study, we generated deletion mutants of HBV envelope L protein (389 amino acid residues (aa)) containing three transmembrane domains (TM1, TM2, TM3)...
June 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28599959/photodynamic-process-induced-by-chloro-aluminum-phthalocyanine-nanoemulsion-in-glioblastoma
#7
Andrielle Castilho-Fernandes, Tácila G Lopes, Fernando L Primo, Marcelo R Pinto, Antonio C Tedesco
BACKGROUND: Glioblastoma multiforme (GBM) is a tumor characterized by rapid cell proliferation and migration. GBM constitutes the most aggressive and deadly type of brain tumor and is classified into several subtypes that show high resistance to conventional therapies. There are currently no curative treatments for malignant glioma despite the numerous advances in surgical techniques, radiotherapy, and chemotherapy. Therefore, alternative approaches are required to improve GBM treatment...
June 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28597327/the-role-of-the-corpus-callosum-in-pediatric-dysphagia-preliminary-findings-from-a-diffusion-tensor-imaging-study-in-children-with-unilateral-spastic-cerebral-palsy
#8
Lucia Figueiredo Mourão, Kathleen M Friel, Justine Joan Sheppard, Hsing-Ching Kuo, Karen Fontes Luchesi, Andrew M Gordon, Georgia A Malandraki
The purpose of this study is to determine the relationship between the structural integrity of the corpus callosum (CC) and clinical feeding/swallowing performance in children with unilateral spastic cerebral palsy (USCP). Twenty children with USCP, (11 males, 5.11-17.6 yoa) were assessed via the Dysphagia Disorder Survey (DDS) and diffusion tensor imaging. Children were grouped into left hemisphere lesion (LHL; n = 13) and right hemisphere lesion (RHL; n = 7) groups. DTI variables analyzed for three CC regions (anterior, middle, posterior) were: fractional anisotropy (FA), radial diffusivity (RD), mean diffusivity (MD), and fibers count...
June 8, 2017: Dysphagia
https://www.readbyqxmd.com/read/28594080/structural-basis-for-expansion-of-the-genetic-alphabet-by-an-artificial-base-pair
#9
Andreas Marx, Karin Betz, Michiko Kimoto, Kay Diederichs, Ichiro Hirao
Hydrophobic artificial nucleobase pairs without the ability to pair via hydrogen bonds are promising candidates to expand the genetic alphabet. The most successful nucleobase surrogates show little similarity with each other and with their natural counterparts. Thus, it is puzzling how the unnatural molecules are processed by DNA polymerases that have evolved to efficiently work with the natural building blocks. Here we report structural insights into the insertion of one of the most promising hydrophobic unnatural base pairs; the dDs-dPx pair into a DNA strand by a DNA polymerase...
June 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28590216/diagnostic-doses-of-insecticides-for-adult-aedes-aegypti-to-assess-insecticide-resistance-in-cuba
#10
María Magdalena Rodríguez, Ariel Crespo, Daymi Hurtado, Ilario Fuentes, Jorge Rey, Juan Andrés Bisset
The objective of this study was to determine diagnostic doses (DDs) of 5 insecticides for the Rockefeller susceptible strain of Aedes aegypti , using the Centers for Disease Control and Prevention (CDC) bottle bioassay as a tool for monitoring insecticide resistance in the Cuban vector control program. The 30-min DD values determined in this study were 13.5 μg/ml, 6.5 μg/ml, 6 μg/ml, 90.0 μg/ml, and 15.0 μg/ml for cypermethrin, deltamethrin, lambda-cyhalothrin, chlorpyrifos, and propoxur, respectively...
June 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28578126/ultradeformable-liposome-loaded-with-zinc-phthalocyanine-and-ru-nh-nhq-tpy-no-3-for-photodynamic-therapy-by-topical-application
#11
Renata Galvão de Lima, Antonio Cláudio Tedesco, Roberto Santana da Silva, Margaret Jayne Lawrence
Ultradeformable liposomes (UDLs) as a drug delivery system (DDS), prepared from the unsaturated phospholipid, dioleylphosphocholine (DOPC), and containing the non-ionic surfactant Tween 20 as edge activator, have been explored as topical vehicles for zinc phthalocyanine (ZnPc) and the nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) (RuNO) as a photosensitizers for co-generation of (1)O2 and NO as reactive species, respectively. However, in order to ensure that ZnPc was present in the UDLs in its monomeric form - essential for maximal ZnPc photophysical properties - it was necessary to replace 40wt% of the DOPC with the saturated phospholipid, dimyristoylphosphocholine (DMPC)...
May 31, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28576012/hyaluronic-acid-and-carbon-dots-gated-hollow-mesoporous-silica-for-redox-and-enzyme-triggered-targeted-drug-delivery-and-bioimaging
#12
Qinfu Zhao, Shengyu Wang, Yang Yang, Xian Li, Donghua Di, Chungang Zhang, Tongying Jiang, Siling Wang
In this work, a redox and enzyme dual-stimuli responsive drug delivery system (DDS) with tracking function (HMSN-SS-CDPEI@HA) based on carbon dots capped hollow mesoporous silica nanoparticles (HMSN) has been developed for targeted drug delivery. The positively charged CDPEI nanoparticles prepared by polyethylenimine (PEI) were grafted on the pore openings of HMSN through disulfide bonds and were used as "gatekeepers" to trap the drugs within the hollow cavity. The hyaluronic acid (HA), a natural polysaccharide, was further grafted on the surface of HMSN to realize targeted drug delivery, controlled drug release and improved the stability...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28558981/natural-lipids-based-nlc-containing-lidocaine-from-pre-formulation-to-in-vivo-studies
#13
Lígia N M Ribeiro, Márcia C Breitkreitz, Viviane A Guilherme, Gustavo H R da Silva, Verônica M Couto, Simone R Castro, Bárbara O de Paula, Daisy Machado, Eneida de Paula
In a nanotechnological approach we have investigated the use of natural lipids in the preparation of nanostructured lipid carriers (NLC). Three different NLC composed of copaiba oil and beeswax, sweet almond oil and shea butter, and sesame oil and cocoa butter as structural matrices were optimized using factorial analysis; Pluronic® 68 and lidocaine (LDC) were used as the colloidal stabilizer and model encapsulated drug, respectively. The optimal formulations were characterized by different techniques (IR-ATR, DSC, and TEM), and their safety and efficacy were also tested...
May 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28557604/dapsone-hydroxylamine-mediated-alterations-in-human-red-blood-cells-from-endometriotic-patients
#14
Alessandra Andrisani, Gabriella Donà, Chiara Sabbadin, Stefano Dall'Acqua, Elena Tibaldi, Antonella Roveri, Valentina Bosello Travain, Anna Maria Brunati, Guido Ambrosini, Eugenio Ragazzi, Decio Armanini, Luciana Bordin
Endometriosis, an estrogen-dependent chronic gynecological disease in women of reproductive age, is characterized by a systemic inflammation status involving also red blood cells (RBCs). In this study, we evaluated how the protein oxidative status could be involved in the worsening of RBC conditions due to dapsone intake in endometriotic women in potential treatment for skin or infection diseases. Blood samples from two groups of volunteers, control group (CG) and endometriosis patient group (PG), were analyzed for their content of band 3 tyrosine phosphorylation (Tyr-P) and high molecular weight aggregate (HMWA) in membranes, and glutathione (GSH) content and carbonic anhydrase (CA) activity in cytosol...
May 30, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28557571/in-vivo-efficacy-of-an-injectable-microsphere-hydrogel-ocular-drug-delivery-system
#15
Christian R Osswald, Micah J Guthrie, Abigail Avila, Joseph A Valio, William F Mieler, Jennifer J Kang-Mieler
PURPOSE: Demonstrate in vivo that controlled and extended release of a low dose of anti-vascular endothelial growth factor (anti-VEGF) from a microsphere-hydrogel drug delivery system (DDS) has a therapeutic effect in a laser-induced rat model of choroidal neovascularization (CNV). METHODS: Anti-VEGF (ranibizumab or aflibercept) was loaded into poly(lactic-co-glycolic acid) microspheres that were then suspended within an injectable poly(N-isopropylacrylamide)-based thermo-responsive hydrogel DDS...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28553356/asymptomatic-brain-edema-after-hemodialysis-initiation-in-a-patient-with-severe-uremia
#16
Kiichiro Fujisaki, Kaneyasu Nakagawa, Hiroshi Nagae, Toshiaki Nakano, Masatomo Taniguchi, Kosuke Masutani, Takanari Kitazono, Kazuhiko Tsuruya
A 66-year-old man with severe renal insufficiency presented with mild confusion associated with uremia. Cranial magnetic resonance imaging (MRI) showed no remarkable changes. The patient was placed on short-duration hemodialysis (2 hours) with smaller surface area and low blood flow (100 mL/min) to avoid dialysis disequilibrium syndrome (DDS). His consciousness gradually improved and he did not develop apparent DDS symptoms. However, T2-weighted FLAIR MRI showed increased signal intensities bilaterally in the cortical and subcortical areas of the occipital lobe on day 15...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28553112/ionp-doped-nanoparticles-for-highly-effective-nir-controlled-drug-release-and-combination-tumor-therapy
#17
Xudong Fu, Xinjun Wang, Shaolong Zhou, Yanyan Zhang
Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled "off-on" DDS with magnetic resonance imaging and magnetic targeting properties was developed using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28536329/-multilateral-strategies-utilizing-exosomes-for-cancer-therapy
#18
Nao Nishida-Aoki, Takahiro Ochiya
Exosomes are nano-sized extracellular vesicles which transfer their components such as RNA, DNA, and proteins from one cell to another cell. The components are released to the cytoplasm of the recipient cells, having an effect on the cells. Cancerderived exosomes promote cancer progression, invasion, gain of drug resistance, and metastasis. Recently, according to their characteristics, it is expected to apply exosomes to cancer therapies, such as utilizing exosomes as drug delivery systems(DDS) for anticancer drugs and as cancer vaccines to enhance immunity to cancer cells...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28525822/the-interplay-between-diabetes-depression-and-affective-temperaments-a-structural-equation-model
#19
Martino Belvederi Murri, Sara Mamberto, Lucia Briatore, Chiara Mazzucchelli, Mario Amore, Renzo Cordera
BACKGROUND: Diabetes and depression are reciprocally linked, but few studies modeled their interplay considering the influence of affective temperaments (AT) and demographic factors. METHODS: Participants with type 1 and type 2 diabetes (T1DM and T2DM, n=279) recruited from Diabetes Units were assessed with the Beck Depression Inventory (BDI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), Morisky Medication Adherence Scale (MMAS), Diabetes Distress Scale (DDS) and Cumulative Illness Rating Scales (CIRS)...
May 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28499361/dietary-diversity-scores-an-indicator-of-micronutrient-inadequacy-instead-of-obesity-for-chinese-children
#20
Wenzhi Zhao, Kai Yu, Shengjie Tan, Yingdong Zheng, Ai Zhao, Peiyu Wang, Yumei Zhang
BACKGROUND: Micronutrient malnutrition affects the well-being of both adults and children. Dietary diversity score (DDS) is a useful evaluation index with a relatively well-developed guideline by FAO. It's meaningful to assess and predict inadequate micronutrient intakes using DDS in Chinese children, after ruling out the risk of obesity coming with more dietary diversity. METHODS: Data for evaluation were extracted from the Nutrition Study of Preschool Children and School Children, which is a cross-sectional study covering 8 cities of China, including 1694 children in kindergartens and primary schools...
May 12, 2017: BMC Public Health
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