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Zahra Nikfar, Zahra Shariatinia
The ability of (4,4)-armchair CNT and its three phosphate functionalized forms (CNT-nH2PO4, n=1-3) were evaluated as novel drug delivery systems (DDSs) for the two commercially well-known anti-osteoporosis drugs namely alendronate (AL) and etidronate (ET). For this purpose, the DFT calculations were accomplished at both B3LYP and B3PW91 levels using 6-31g(d) basis set. The binding energy was increased by increasing number of H2PO4 moieties attached on the CNT with the most negative binding energy was measured for the carrier containing three phosphate groups...
July 8, 2017: Journal of Molecular Graphics & Modelling
Yunhee Kang, Jane Kim, Eunkyo Seo
Few studies have explored the potential of social capital in improving child nutritional status; however, most components of pathways between social capital and nutritional status have remained unexplained. Complementary feeding practice is a strong mediator of child nutritional status. This study examined the association between complementary feeding practice and maternal social capital in rural Ethiopia, using cross-sectional data of infant aged 6-12 months and their mother pairs (n = 870). The Short Social Capital Assessment Tool was used to assess maternal structural (i...
July 17, 2017: Maternal & Child Nutrition
Masanori Maeda, Yoshihiro Muragaki, Jun Okamoto, Shin Yoshizawa, Nobutaka Abe, Hidekazu Nakamoto, Hiroshi Ishii, Kenichi Kawabata, Shinichiro Umemura, Nobuhiro Nishiyama, Kazunori Kataoka, Hiroshi Iseki
Sonodynamic therapy (SDT) is currently considered as one of the promising minimally invasive treatment options for solid cancers. SDT is based on the combined use of a sonosensitizer drug and high-intensity focused ultrasound (HIFU) to produce cytotoxic reactive oxygen species (ROS) in and around neoplastic cells. Anthracycline drugs, including epirubicin (EPI), have been well known as effective sonosensitizers after interaction with focused ultrasound. Recently a new anticancer drug delivery system (DDS), NC-6300, has been developed that comprises EPI through an acid-labile hydrazone bond...
July 10, 2017: Ultrasound in Medicine & Biology
Ye Zhang, Congjun Zhang, Jing Chen, Li Liu, Mengyue Hu, Jun Li, Hong Bi
Multidrug resistance (MDR) has been recognized as a major obstacle to successful chemotherapy for cancer in the clinic. In recent years, more and more nanoscaled drug delivery systems (DDS) are constructed to modulate drug efflux protein (P-gp) and deliver chemotherapeutic drugs for overcoming MDR. Among them, D-α-tocopheryl polyethylene glycol succinate (TPGS) has been widely used as a drug carrier due to its capability of inhibiting overexpression of P-gp and good amphiphilicity favorable for improving permeation and long-circulation property of DDS...
July 11, 2017: ACS Applied Materials & Interfaces
Ruixiang Li, Zhiqing Pang, Huining He, Seungjin Lee, Jing Qin, Jian Wu, Liang Pang, Jianxin Wang, Victor C Yang
Localized and long-term delivery of growth factors has been a long-standing challenge for stem cell-based tissue engineering. In the current study, a polymeric drug depot-anchoring hydrogel scaffold was developed for the sustained release of macromolecules to enhance the differentiation of stem cells. Self-assembling peptide (RADA16)-modified drug depots (RDDs) were prepared and anchored to a RADA16 hydrogel. The anchoring effect of RADA16 modification on the RDDs was tested both in vitro and in vivo. It was shown that the in vitro leakage of RDDs from the RADA16 hydrogel was significantly less than that of the unmodified drug depots (DDs)...
July 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
Ke Jiang, Ling Zhang, Quan Hu, Qi Zhang, Wenxin Lin, Yuanjing Cui, Yu Yang, Guodong Qian
Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequently dose in the traditional therapeutic method. In our work, a Zr-based metal-organic framework named ZJU-801, which is isoreticular with NU-801, has been designed and further demonstrated as an excellent drug delivery system (DDS) with a high drug loading of 41.7 %. Such a high drug loading capacity may be ascribed to the appropriate match of the size and the large pore volume of this kind of Zr MOF material...
July 6, 2017: Chemistry: a European Journal
Amie C Myrick, Aliya R Webermann, Richard J Loewenstein, Ruth Lanius, Frank W Putnam, Bethany L Brand
Objective: Literature on the treatment of dissociative disorders (DDs) suggests that these individuals require long-term and specialized treatment to achieve stabilization and functionality. There is considerable empirical support for specialized phasic, dissociation-focused treatment in reducing a myriad of psychological symptoms and self-harm in this population. However, until recently, there has been a paucity of longitudinal treatment research on DD patients. Method: In the present six-year follow-up study, 61 therapists who participated in the initial phase of the Treatment of Patients with Dissociative Disorders (TOP DD) study answered questionnaires about their study patient's stressors, quality of life, global functioning, victimization, and safety...
2017: European Journal of Psychotraumatology
Yun Sun Lee, Hyun-Seung Park, Dong-Kyu Lee, Murukarthick Jayakodi, Nam-Hoon Kim, Hyun Jo Koo, Sang-Choon Lee, Yeon Jeong Kim, Sung Won Kwon, Tae-Jin Yang
Panax ginseng C.A. Meyer is a traditional medicinal herb that produces bioactive compounds such as ginsenosides. Here, we investigated the diversity of ginsenosides and related genes among five genetically fixed inbred ginseng cultivars (Chunpoong [CP], Cheongsun [CS], Gopoong [GO], Sunhyang [SH], and Sunun [SU]). To focus on the genetic diversity related to ginsenoside biosynthesis, we utilized in vitro cultured adventitious roots from the five cultivars grown under controlled environmental conditions. PCA loading plots based on secondary metabolite composition classified the five cultivars into three groups...
2017: Frontiers in Plant Science
Masayori Hagimori, Yuki Fuchigami, Shigeru Kawakami
Targeting cancer cell-surface receptors is an attractive approach for cancer treatment and diagnosis. Peptides having high binding affinities to receptors overexpressed in cancer cells are useful because of their simple structure, low immunogenicity, and easy, cost-effective chemical synthesis. A number of peptide ligands have been developed for cancer cell-surface receptors and applied to nanoparticles with anticancer drugs, genes, small interfering RNAs (siRNAs), and molecular imaging agents. In particular, recent findings have revealed that peptide-modified PEGylated liposome-encapsulated drugs are effective in cancer-targeted therapy and cancer cell-specific imaging...
2017: Chemical & Pharmaceutical Bulletin
Shang-Hsuan Lee, Yusuke Sato, Mamoru Hyodo, Hideyoshi Harashima
In the active targeting of a drug delivery system (DDS), the density of the ligand on the functionalized liposome determines its affinity for binding to the target. To evaluate these densities on the surface of different sized liposomes, 4 liposomes with various diameters (188, 137, 70, 40 nm) were prepared and their surfaces were modified with fluorescently labeled ligand-lipid conjugates by the post-insertion method. Each liposomal mixture was fractionated into a series of fractions using size exclusion chromatography (SEC), and the resulting liposome fractions were precisely analyzed and the surface ligand densities calculated...
2017: Biological & Pharmaceutical Bulletin
Jannike Mohn, Marit Graue, Jõrg Assmus, Vibeke Zoffmann, Hrafnkell Thordarson, Mark Peyrot, Berit Rokne
OBJECTIVES: To determine whether the impact of guided self-determination (GSD) applied in group training (GSD-GT) in people with chronically elevated HbA1c and type 1 diabetes mellitus (DM) was superior to 'care as usual' in improving HbA1c and psychological functioning. SETTING: An outpatient clinic at a university hospital in Western Norway. PARTICIPANTS: A total of 178 adults (all Caucasian) aged 18-55 (mean age 36.7±10.7, 62% women) with type 1 DM for at least 1 year and HbA1c ≥64 mmol/mol (8...
July 3, 2017: BMJ Open
Marianne Sandsmark Morseth, Navnit Kaur Grewal, Ida Sophie Kaasa, Anne Hatloy, Ingrid Barikmo, Sigrun Henjum
BACKGROUND: There is limited knowledge about dietary quality among the adult population in low- and middle income countries (LMICs). This study aims to describe dietary quality among the adult Saharawi refugee population and to investigate whether dietary quality is associated with socioeconomic status. METHODS: In 2014, a cross-sectional survey was carried out in the Saharawi refugee camps, Algeria. A three-staged cluster sampling was performed and 180 women and 175 men, aged 18-82 years, were randomly selected...
July 3, 2017: BMC Public Health
Puria Motamed Fath, Fatemeh Yazdian, Rogayyeh Jamjah, Bahman Ebrahimi Hosseinzadeh, Maede Rahimnezhad, Razi Sahraeian, Ashrafalsadat Hatamian
OBJECTIVE: Poly [2-methacryloyloxyethyl phosphoryl choline (MPC)-co-n-buthyl methacrylate (BMA)-co-p-nitrophenyl-oxycrabonyl poly ethylene glycol-methacrylate (ME- ONP)] (PMBN), a biocompatible terpolymer, is a unique polymer with applications that range from drug delivery systems (DDS) to scaffolds and biomedical devices. In this research, we have prepared a monomer of p-nitrophenyl-oxycarbonyl poly (ethylene glycol) methacrylate (MEONP) to synthesize this polymer. Next, we designed and prepared a smart, water soluble, amphiphilic PMBN polymer composed of MPC, BMA, and MEONP...
July 2017: Cell Journal
Xiao Sun, Ruohong Du, Li Zhang, Guilong Zhang, Xiaojia Zheng, Junchao Qian, Xiaohe Tian, Jiewen Zhou, Jiacai He, Yuanyin Wang, Yiqun Wu, Kai Zhong, Dongqing Cai, Duohong Zou, Zhengyan Wu
Incorporation of T1 and T2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as efficient drug delivery system (DDS) had significantly potential application for clinical diagnosis and chemotherapy of cancer. However, inappropriate incorporation always encountered many issues, such as low contact area of T1 contrast material with water-proton, inappropriate distance between T2 contrast material and water molecule, and undesirable disturbance of T2 contrast material for T1 imaging...
June 30, 2017: ACS Nano
Paulina Wojtyła-Buciora, Aneta Klimberg, Lucyna Kapka-Skrzypczak, Jarosław Diatczyk, Monika Urbaniak, Ewa Ulatowska-Szostak, Tomasz Bołdowski, Andrzej Wojtyła, Jerzy T Marcinkowski
<b>Introduction.</b> Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. <b>Objectives.</b> To estimate the amount and incidence of drug consumption in middle and high school pupils, including the circumstances in which drug taking first started, and to determine pupils' knowledge about the consequences of taking psychoactive substances and designer drugs (DDs). <b>Materials and methods</b>...
June 6, 2017: Annals of Agricultural and Environmental Medicine: AAEM
Kohei Takizawa, Mary A Knipschield, Christopher J Gostout
OBJECTIVES: In Western countries ESD (Endoscopic Submucosal Dissection) has not prevailed due to training issues and a target patient population. We reported a hybrid ESD technique, SEMR (submucosal endoscopy with mucosal resection), in which the submucosal dissection is performed chiefly by blunt balloon dissection. We have reported successful application in the porcine colon. In this study we compared the safety and efficacy between SEMR with ESD in the porcine esophagus and stomach...
June 30, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Guixia Li, Lianming Zhao, Houyu Zhu, Xiuping Liu, Huifang Ma, Yanchen Yu, Wenyue Guo
The hydrodesulfurization (HDS) of thiophene on clean and S-modified MoP(010) is investigated to understand the HDS mechanism as well as the surface sulfur (S) atom effect using periodic density functional theory (DFT). The results show that thiophene prefers strongly flat adsorption on both the clean and S-modified surfaces, in either the molecular state or the dissociative state breaking simultaneously one C-S bond, and the adsorption of thiophene can be slightly weakened by the surface S atom. Thermodynamic and kinetic analysis indicates that the HDS of thiophene in both the molecular and dissociative adsorption states prefers to take place along the direct desulfurization (DDS) pathway rather than hydrogenation on both the clean and S-modified MoP(010) surfaces...
June 26, 2017: Physical Chemistry Chemical Physics: PCCP
Bustanul Arifin S Farm, Dyah Aryani Perwitasari, Jarir At Thobari, Qi Cao, Paul F M Krabbe, Maarten J Postma
OBJECTIVES: To translate, revise, and validate the Diabetes Distress Scale (DDS) instrument for Indonesian type 2 diabetes mellitus (T2DM) outpatients with various complications. METHODS: Participants were recruited from four hospitals and two primary health care centers. The study was performed with forward and backward translations, an adaptation testing with a small subset of participants, and validation analysis. Factor analysis with maximum likelihood estimation and promax rotation was then used to investigate the instrument structure...
May 2017: Value in Health Regional Issues
Jeremy Fry, Robert Keim
No abstract text is available yet for this article.
March 2017: Journal of Clinical Orthodontics: JCO
Allison M Veitenheimer, Jarrad R Wagner
Drugged driving has become more prevalent than drunk driving and is quickly gaining national attention due to increased prescription drug abuse and recent cannabis legalization. Unlike alcohol, police officers do not generally have access to approved devices to screen for drugs at the roadside. Onsite drug screening devices do exist and are used in other countries, but have not garnered widespread approval for use in the United States in driving under the influence of drugs (DUID) cases. One reason for this is that the devices are designed to test oral fluid, which is not a commonly accepted specimen for DUID...
June 13, 2017: Journal of Analytical Toxicology
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