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JOURNAL ARTICLE
Jean B Nachega, Nadia A Sam-Agudu, Rhoderick N Machekano, Helena Rabie, Marieke M van der Zalm, Andrew Redfern, Angela Dramowski, Natasha O'Connell, Michel Tshiasuma Pipo, Marc B Tshilanda, Liliane Nsuli Byamungu, Refiloe Masekela, Prakash Mohan Jeena, Ashendri Pillay, Onesmus W Gachuno, John Kinuthia, Daniel Katuashi Ishoso, Emmanuella Amoako, Elizabeth Agyare, Evans K Agbeno, Charles Martyn-Dickens, Justice Sylverken, Anthony Enimil, Aishatu Mohammed Jibril, Asara M Abdullahi, Oma Amadi, Umar Mohammed Umar, Lovemore Nyasha Sigwadhi, Michel P Hermans, John Otshudiema Otokoye, Placide Mbala-Kingebeni, Jean-Jacques Muyembe-Tamfum, Alimuddin Zumla, Nelson K Sewankambo, Hellen Tukamuhebwa Aanyu, Philippa Musoke, Fatima Suleman, Prisca Adejumo, Emilia V Noormahomed, Richard J Deckelbaum, Mary Glenn Fowler, Léon Tshilolo, Gerald Smith, Edward J Mills, Lawal W Umar, Mark J Siedner, Mariana Kruger, Philip J Rosenthal, John W Mellors, Lynne M Mofenson
Importance: Little is known about COVID-19 outcomes among children and adolescents in sub-Saharan Africa, where preexisting comorbidities are prevalent. Objective: To assess the clinical outcomes and factors associated with outcomes among children and adolescents hospitalized with COVID-19 in 6 countries in sub-Saharan Africa. Design, Setting, and Participants: This cohort study was a retrospective record review of data from 25 hospitals in the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa, and Uganda from March 1 to December 31, 2020, and included 469 hospitalized patients aged 0 to 19 years with SARS-CoV-2 infection...
January 19, 2022: JAMA Pediatrics
#22
Priya R Edward, Ramon Lorenzo-Redondo, Megan E Reyna, Lacy M Simons, Judd F Hultquist, Ami B Patel, Egon A Ozer, William J Muller, Taylor Heald-Sargent, Matthew McHugh, Taylor J Dean, Raj M Dalal, Jordan John, Shannon C Manz, Larry K Kociolek
BACKGROUND: Recent surges in coronavirus 2019 disease (COVID-19) is attributed to the emergence of more transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs). However, the relative severity of SARS-CoV-2 VOCs in children is unknown. METHODS: This retrospective single-center cohort study was performed at the Ann & Robert H. Lurie Children's Hospital of Chicago, academic free-standing children's hospital. We included all children ≤ 18 years-old diagnosed with COVID-19 between October 15 th , 2020 and August 31 st , 2021 and whose SARS-CoV-2 isolate was sequenced using the Illumina platform...
October 26, 2021: medRxiv
#23
JOURNAL ARTICLE
Joyce C Chang, Daisuke Matsubara, Ryan W Morgan, Caroline Diorio, Sumekala Nadaraj, David T Teachey, Hamid Bassiri, Edward M Behrens, Anirban Banerjee
Background Cardiac dysfunction is a prominent feature of multisystem inflammatory syndrome in children (MIS-C), yet the etiology is poorly understood. We determined whether dysfunction is global or regional, and whether it is associated with the cytokine milieu, microangiopathy, or severity of shock. Methods and Results We analyzed echocardiographic parameters of myocardial deformation and compared global and segmental left ventricular strain between 43 cases with MIS-C ≤18 years old and 40 controls. Primary outcomes included left ventricular global longitudinal strain, right ventricular free wall strain), and left atrial strain...
August 17, 2021: Journal of the American Heart Association
#24
JOURNAL ARTICLE
Edward Y Lee, Sara O Vargas, Jonathan M Gaffin, Janet Chou, Halley J Park, Abbey J Winant
PURPOSE: To investigate the characteristic thoracic multidetector computed tomography (MDCT) findings of dedicator of cytokinesis 8 (DOCK8) deficiency, a rare autosomal recessive form of hyperimmunoglobulin E syndrome, in children. MATERIALS AND METHODS: All pediatric patients (age 18 y and below) with a known diagnosis of DOCK8 deficiency based on genetic testing who underwent thoracic MDCT studies from November 2004 to November 2020 were included. Two pediatric radiologists independently evaluated MDCT studies for the presence of thoracic abnormalities in the lung [ground-glass opacity (GGO), consolidation, pulmonary nodule, mass, cyst, and bronchiectasis], pleura (pleural effusion and pneumothorax), and mediastinum (lymphadenopathy)...
March 22, 2021: Journal of Thoracic Imaging
#25
JOURNAL ARTICLE
Alaa Montaser, Jessica Driscoll, Hudson Smith, Madeline B Karsten, Emily Day, Tina Mounlavongsy, Darren B Orbach, Edward R Smith
OBJECTIVE: Isolated anterior cerebral artery (ACA) territory ischemia in pediatric moyamoya disease (MMD) is rare but has been increasingly recognized, particularly in children manifesting progression of disease in a delayed fashion after middle cerebral artery revascularization surgery. Surgical treatment is complicated by limited graft choices, with the small number of case series largely focused on complex, higher-risk operations (omental flap transfers, large interhemispheric rotational grafts); direct bypass (often untenable in children due to vessel size); or, alternatively, the technically simpler method of multiple burr holes (of limited efficacy outside of infants)...
July 2, 2021: Journal of Neurosurgery. Pediatrics
#26
JOURNAL ARTICLE
Amaro Nunes Duarte-Neto, Elia Garcia Caldini, Michele Soares Gomes-Gouvêa, Cristina Takami Kanamura, Renata Aparecida de Almeida Monteiro, Juliana Ferreira Ferranti, Andrea Maria Cordeiro Ventura, Fabiane Aliotti Regalio, Daniela Matos Fiorenzano, Maria Augusta Bento Cicaroni Gibelli, Werther Brunow de Carvalho, Gabriela Nunes Leal, João Renato Rebello Pinho, Artur Figueiredo Delgado, Magda Carneiro-Sampaio, Thais Mauad, Luiz Fernando Ferraz da Silva, Paulo Hilario Nascimento Saldiva, Marisa Dolhnikoff
BACKGROUND: COVID-19 in children is usually mild or asymptomatic, but severe and fatal paediatric cases have been described. The pathology of COVID-19 in children is not known; the proposed pathogenesis for severe cases includes immune-mediated mechanisms or the direct effect of SARS-CoV-2 on tissues. We describe the autopsy findings in five cases of paediatric COVID-19 and provide mechanistic insight into the mechanisms involved in the pathogenesis of the disease. METHODS: Children and adolescents who died with COVID-19 between March 18 and August 15, 2020 were autopsied with a minimally invasive method...
May 2021: EClinicalMedicine
#27
JOURNAL ARTICLE
Erin E Birmingham, Astrid G Stucke, Christina D Diaz
BACKGROUND: Trisomy 18 or Edwards syndrome is the second most common aneuploidy with a prevalence between 1/3000 and 1/10 000 live births. The syndrome encompasses malformations of the central nervous, cardiac, respiratory, gastrointestinal, and genitourinary systems. Trisomy 18 carries a poor prognosis with 90% of patients not surviving beyond 1 year of age; however, the current trend toward more aggressive supportive care may prolong survival. The limited anesthesia literature highlights the abnormal airway anatomy but generally describes uneventful airway management and perioperative course...
April 2021: Paediatric Anaesthesia
#28
COMPARATIVE STUDY
Michael A Belsky, Anisha Konanur, Edward Sim, Annie Yan, Amber D Shaffer, Kathryn Williams, Grant R Martsolf, David Chi, Noel Jabbour
OBJECTIVE/HYPOTHESIS: Advanced practice provider (APP) employment is becoming common in pediatric otolaryngology practices, though few studies have evaluated the consequences that APP-led clinics have on access to care. The objectives of this study were: 1) to investigate whether access to bilateral myringotomy with tympanostomy tube placement (BMT) for recurrent acute otitis media (RAOM) differed between patients seen in otolaryngologist and APP-led clinics 2) to compare clinical characteristics of patients seen by provider type...
September 2021: Laryngoscope
#29
REVIEW
Jeffrey W Kepple, Kristen P Fishler, Eric S Peeples
Trisomy 18 is the second most common aneuploidy syndromes in live born infants. It is associated with high mortality rates, estimated to be 75%-95% in the first year of life, as well as significant morbidity in survivors. The low survival is largely due to the high prevalence of severe congenital anomalies in infants with this diagnosis. However, interventions to repair or palliate those life-threatening anomalies are being performed at a higher rate for these infants, resulting in increased rates of survival beyond the first year of life...
April 2021: American Journal of Medical Genetics. Part A
#30
COMPARATIVE STUDY
Bradley S Rostad, Jay H Shah, Christina A Rostad, Preeti Jaggi, Edward J Richer, Leann E Linam, Adina L Alazraki, Erica L Riedesel, Sarah S Milla
BACKGROUND: Although the radiographic features of coronavirus disease 2019 (COVID-19) in children have been described, the distinguishing features of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 are not well characterized. OBJECTIVE: We compared the chest radiographic findings of MIS-C with those of COVID-19 and described other distinguishing imaging features of MIS-C. MATERIALS AND METHODS: We performed a retrospective case series review of children ages 0 to 18 years who were hospitalized at Children's Healthcare of Atlanta from March to May 2020 and who either met the Centers for Disease Control and Prevention (CDC) case definition for MIS-C (n=11) or who had symptomatic, laboratory-confirmed COVID-19 (n=16)...
February 2021: Pediatric Radiology
#31
JOURNAL ARTICLE
Caroline Diorio, Kevin O McNerney, Michele Lambert, Michele Paessler, Elizabeth M Anderson, Sarah E Henrickson, Julie Chase, Emily J Liebling, Chakkapong Burudpakdee, Jessica H Lee, Frances B Balamuth, Allison M Blatz, Kathleen Chiotos, Julie C Fitzgerald, Therese M Giglia, Kandace Gollomp, Audrey R Odom John, Cristina Jasen, Tomas Leng, Whitney Petrosa, Laura A Vella, Char Witmer, Kathleen E Sullivan, Benjamin L Laskin, Scott E Hensley, Hamid Bassiri, Edward M Behrens, David T Teachey
Most children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have mild or minimal disease, with a small proportion developing severe disease or multisystem inflammatory syndrome in children (MIS-C). Complement-mediated thrombotic microangiopathy (TMA) has been associated with SARS-CoV-2 infection in adults but has not been studied in the pediatric population. We hypothesized that complement activation plays an important role in SARS-CoV-2 infection in children and sought to understand if TMA was present in these patients...
December 8, 2020: Blood Advances
#32
JOURNAL ARTICLE
Ida C B Lund, Olav B Petersen, Naja H Becher, Dorte L Lildballe, Finn S Jørgensen, Louise Ambye, Lillian Skibsted, Anja Ernst, Ann N Jensen, Christina Fagerberg, Charlotte Brasch-Andersen, Ann Tabor, Helle J Zingenberg, Pernille Nørgaard, Gitte J Almind, Else Marie Vestergaard, Ida Vogel
INTRODUCTION: In Denmark, non-invasive prenatal testing (NIPT) has been used since 2013. We aimed to evaluate the early clinical use of NIPT in Danish public and private healthcare settings before NIPT became an integrated part of the national guidelines on prenatal screening and diagnosis in 2017. MATERIAL AND METHODS: NIPT data were collected between March 2013 and June 2017 from national public registries and private providers. Results from follow-up samples (chorionic villi, amniotic fluid, postnatal blood or fetal tissue) were included from The Danish Cytogenetics Central Registry and indications and outcome from The Danish Fetal Medicine Database...
May 2021: Acta Obstetricia et Gynecologica Scandinavica
#33
Talita Duarte-Salles, David Vizcaya, Andrea Pistillo, Paula Casajust, Anthony G Sena, Lana Yin Hui Lai, Albert Prats-Uribe, Waheed-Ul-Rahman Ahmed, Thamir M Alshammari, Heba Alghoul, Osaid Alser, Edward Burn, Seng Chan You, Carlos Areia, Clair Blacketer, Scott DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Stephen Fortin, Asieh Golozar, Mengchun Gong, Eng Hooi Tan, Vojtech Huser, Pablo Iveli, Daniel R Morales, Fredrik Nyberg, Jose D Posada, Martina Recalde, Elena Roel, Lisa M Schilling, Nigam H Shah, Karishma Shah, Marc A Suchard, Lin Zhang, Andrew E Williams, Christian G Reich, Kristin Kostka, Daniel Prieto-Alhambra
Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort. Setting Real-world data from European primary care records (France/Germany/Spain), South Korean claims and US claims and hospital databases. Participants Diagnosed and/or hospitalized children/adolescents with COVID-19 at age <18 between January and June 2020; diagnosed with influenza in 2017-2018...
October 30, 2020: medRxiv
#34
JOURNAL ARTICLE
Ankita Desai, Alexandra Mills, Sarah Delozier, Claudia Cabrera Aviles, Amy Edwards, Sahera Dirajlal-Fargo, Grace McComsey
Background Few reports have been published on the clinical presentation of pediatric patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We aim to shed more light on the clinical presentation of pediatric patients infected with coronavirus disease 2019 (COVID-19), and also potential risk factors for more severe clinical case presentation. Methods We used a large global health research network to gather clinical data extracted from the electronic medical records of pediatric patients aged < 18 years with confirmed SARS-CoV-2 from January 1, 2020 to May 7, 2020...
September 12, 2020: Curēus
#35
JOURNAL ARTICLE
Edward Buratto, Thomas Hu, Adrienne Lui, Damien M Wu, Yves d'Udekem, Christian P Brizard, Igor E Konstantinov
OBJECTIVES: Complete atrioventricular septal defect (cAVSD) repair is usually performed between 3 and 6 months of age. However, some children present with early heart failure requiring intervention. It is unclear whether primary complete repair or initial pulmonary artery banding (PAB) provides better outcomes. METHODS: All patients (n = 194) who underwent surgery for cAVSD younger than 3 months of age between 1990 and 2019 were included. Propensity score matching was performed on risk factors for mortality...
May 2021: Journal of Thoracic and Cardiovascular Surgery
#36
JOURNAL ARTICLE
Lael M Yonker, Anne M Neilan, Yannic Bartsch, Ankit B Patel, James Regan, Puneeta Arya, Elizabeth Gootkind, Grace Park, Margot Hardcastle, Anita St John, Lori Appleman, Michelle L Chiu, Allison Fialkowski, Denis De la Flor, Rosiane Lima, Evan A Bordt, Laura J Yockey, Paolo D'Avino, Stephanie Fischinger, Jessica E Shui, Paul H Lerou, Joseph V Bonventre, Xu G Yu, Edward T Ryan, Ingrid V Bassett, Daniel Irimia, Andrea G Edlow, Galit Alter, Jonathan Z Li, Alessio Fasano
OBJECTIVES: As schools plan for re-opening, understanding the potential role children play in the coronavirus infectious disease 2019 (COVID-19) pandemic and the factors that drive severe illness in children is critical. STUDY DESIGN: Children ages 0-22 years with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting to urgent care clinics or being hospitalized for confirmed/suspected SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) at Massachusetts General Hospital were offered enrollment in the Massachusetts General Hospital Pediatric COVID-19 Biorepository...
December 2020: Journal of Pediatrics
#37
REVIEW
Myy Mikwar, Amanda J MacFarlane, Francesco Marchetti
It is well established that maternal age is associated with a rapid decline in the production of healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years of age. In particular, chromosome segregation errors during meiotic divisions are increasingly common and lead to the production of oocytes with an incorrect number of chromosomes, a condition known as aneuploidy. When an aneuploid oocyte is fertilized by a sperm it gives rise to an aneuploid embryo that, except in rare situations, will result in a spontaneous abortion...
July 2020: Mutation Research
#38
JOURNAL ARTICLE
Kim R Derespina, Shubhi Kaushik, Anna Plichta, Edward E Conway, Asher Bercow, Jaeun Choi, Ruth Eisenberg, Jennifer Gillen, Anita I Sen, Claire M Hennigan, Lillian M Zerihun, Sule Doymaz, Michael A Keenaghan, Stephanie Jarrin, Franscene Oulds, Manoj Gupta, Louisdon Pierre, Melissa Grageda, H Michael Ushay, Vinay M Nadkarni, Michael S D Agus, Shivanand S Medar
OBJECTIVES: To describe the clinical manifestations and outcomes of critically ill children with coronavirus disease-19 (COVID-19) in New York City. STUDY DESIGN: Retrospective observational study of children 1 month to 21 years admitted March 14 to May 2, 2020, to 9 New York City pediatric intensive care units (PICUs) with severe acute respiratory syndrome coronavirus 2 infection. RESULTS: Of 70 children admitted to PICUs, median age was 15 (IQR 9, 19) years; 61...
November 2020: Journal of Pediatrics
#39
MULTICENTER STUDY
Shubhi Kaushik, Scott I Aydin, Kim R Derespina, Prerna B Bansal, Shanna Kowalsky, Rebecca Trachtman, Jennifer K Gillen, Michelle M Perez, Sara H Soshnick, Edward E Conway, Asher Bercow, Howard S Seiden, Robert H Pass, Henry M Ushay, George Ofori-Amanfo, Shivanand S Medar
OBJECTIVE: To assess clinical characteristics and outcomes of severe acute respiratory syndrome coronavirus 2-associated multisystem inflammatory syndrome in children (MIS-C). STUDY DESIGN: Children with MIS-C admitted to pediatric intensive care units in New York City between April 23 and May 23, 2020, were included. Demographic and clinical data were collected. RESULTS: Of 33 children with MIS-C, the median age was 10 years; 61% were male; 45% were Hispanic/Latino; and 39% were black...
September 2020: Journal of Pediatrics
#40
JOURNAL ARTICLE
Sharman P Tan Tanny, Edward Fearon, Alisa Hawley, Jo-Anne Brooks, Assia Comella, John M Hutson, Warwick J Teague, Anastasia Pellicano, Sebastian K King
OBJECTIVE: To describe esophageal atresia mortality rates and their associations in our cohort. STUDY DESIGN: Patients with esophageal atresia, managed at The Royal Children's Hospital, Melbourne (1980-2018), who subsequently died, were retrospectively identified from the prospective Nate Myers Oesophageal Atresia database. Data collected included patient and maternal demographics, vertebral anomalies, anorectal malformations, cardiovascular anomalies, tracheoesophageal fistula, renal anomalies, and limb defects (VACTERL) associations, mortality risk factors, and preoperative, operative, and postoperative findings...
April 2020: Journal of Pediatrics
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