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Primary hyperparathyroidism

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https://www.readbyqxmd.com/read/29341944/nuclear-medicine-methods-for-evaluation-of-abnormal-parathyroid-glands-in-patients-with-primary-and-secondary-hyperparathyroidism
#1
Albena D Botushanova, Nikolay P Botushanov, Marianna P Yaneva
Considered rare disease in the past, primary hyperparathyroidism (PHPT) has dramatically increased in incidence over the past thirty years with the introduction of routine calcium measurements; it is now approximately 42 per 100 000 persons. By far, the most common lesion found in patients with PHPT is the solitary parathyroid adenoma, occurring in 85%-90% of patients, while in the rest 10%- 15% primary hyperplasia of the parathyroid glands is present. Currently, the most widely used surgical approach is minimally invasive parathyroidectomy which is associated with less post-surgery complications and shorter operation time...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29340322/paricalcitol-versus-calcifediol-for-treating-hyperparathyroidism-in-kidney-transplant-recipients
#2
Josep M Cruzado, Ricardo Lauzurica, Julio Pascual, Roberto Marcen, Francesc Moreso, Alex Gutierrez-Dalmau, Amado Andrés, Domingo Hernández, Armando Torres, Maria Isabel Beneyto, Edoardo Melilli, Anna Manonelles, Manuel Arias, Manuel Praga
Introduction: Secondary hyperparathyroidism (SHPT) and vitamin D deficiency are common at kidney transplantation and are associated with some early and late complications. This study was designed to evaluate whether paricalcitol was more effective than nutritional vitamin D for controlling SHPT in de novo kidney allograft recipients. Methods: This was a 6-month, investigator-initiated, multicenter, open-label, randomized clinical trial. Patients with pretransplantation iPTH between 250 and 600 pg/ml and calcium <10 mg/dl were randomized to paricalcitol (PAR) or calcifediol (CAL)...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29339573/-sup-18-sup-f-choline-pet-ct-for-parathyroid-scintigraphy-significantly-lower-radiation-exposure-of-patients-in-comparison-to-conventional-nuclear-medicine-imaging-approaches
#3
Sebastijan Rep, Marko Hocevar, Janja Vaupotič, Urban Zdesar, Katja Zaletel, Luka Lezaic
Parathyroid subtraction scintigraphy is the most commonly used imaging method for localization of hyperfunctioning parathyroid glands (HPG) in primary hyperparathyroidism, a common endocrine disorder. Hybrid (SPECT/CT) imaging with 99mTc-sestaMIBI (MIBI) at an early and delayed phase (dual-phase imaging) may be the most accurate conventional imaging approach, but includes additional radiation exposure due to added CT imaging. Recently, 18F-choline (FCH) PET/CT was introduced for HPG imaging, which can also be performed using the dual-phase approach...
January 17, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29335763/18f-fluorocholine-pet-ct-as-a-second-line-nuclear-imaging-technique-before-surgery-for-primary-hyperparathyroidism
#4
EDITORIAL
Alessio Imperiale, David Taïeb, Elif Hindié
No abstract text is available yet for this article.
January 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29330338/diagnosis-management-histology-and-genetics-of-sporadic-primary-hyperparathyroidism-old-knowledge-with-new-tricks
#5
Maria Mizamtsidi, Constantinos Nastos, George Mastorakos, Roberto Dina, Ioannis Vassiliou, Maria Gazouli, Fausto Palazzo
Primary hyperparathyroidism (pHPT) is a common endocrinopathy resulting from inappropriately high PTH secretion. It usually results from the presence of a single gland adenoma, multiple gland hyperplasia or rarely parathyroid carcinoma. All these conditions require different management and it is important to be able to differentiate the underlined pathology, in order for the clinicians to provide the best therapeutic approach. Elucidation of the genetic background of each of these clinical entities would be of great interest...
January 12, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29322171/optimal-use-of-preoperative-imaging-in-primary-hyperparathyroidism-reply
#6
Shonan Sho, Michael W Yeh, Ali R Sepahdari
No abstract text is available yet for this article.
January 10, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29322170/optimal-use-of-preoperative-imaging-in-primary-hyperparathyroidism
#7
Emma Collins, Sriram Vaidyanathan, Andrew Scarsbrook
No abstract text is available yet for this article.
January 10, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29317405/coagulation-and-fibrinolysis-in-hyperparathyroidism-secondary-to-vitamin-d-deficiency
#8
Laura P B Elbers, Marije Wijnberge, Joost C M Meijers, Dennis C W Poland, Dees P M Brandjes, Eric Fliers, Victor E A Gerdes
INTRODUCTION: Abnormal coagulation tests have been observed in patients with primary hyperparathyroidism (HPT) suggesting a prothrombotic effect of parathyroid hormone (PTH). Vitamin D deficiency (VIDD) is the most frequent cause of secondary HPT. Aim of our study was to investigate the influence of HPT secondary to moderate-severe VIDD and vitamin D replacement on the coagulation and fibrinolysis system. SUBJECTS AND METHODS: Prospective cohort study of patients with vitamin D<25 nmol/l with and without HPT, and a control group of patients on vitamin D suppletion...
January 9, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29310821/sestamibi-spect-ct-versus-spect-only-for-preoperative-localization-in-primary-hyperparathyroidism-a-single-institution-8-year-analysis
#9
Kelly L McCoy, Anish G Ghodadra, Trilochan G Hiremath, Angela Albarano, Judith M Joyce, Linwah Yip, Sally E Carty, Ashok Muthukrishnan
BACKGROUND: Primary hyperparathyroidism is caused by single gland disease in 85% of cases and by multiglandular disease in 15%. Our aim was to discover if the addition of computed tomography acquisition/fusion on a hybrid scanner to traditional dual-phase single-photon emission tomography improves localization accuracy. METHODS: A prospective database was queried for the perioperative data of patients with sporadic primary hyperparathyroidism who had initial exploration from 2006-2014 with ≥6 month follow-up to define anatomy...
January 5, 2018: Surgery
https://www.readbyqxmd.com/read/29306227/parathyroid-hormone-in-washout-fluid-seems-to-be-superior-to-cytology-for-localization-of-the-lesion-in-mibi-negative-patients-with-primary-hyperparathyroidism
#10
Güven Barış Cansu, Bengür Taşkıran, Hayrettin Dizen, Betül Peker Cengiz
Background/aim: Primary hyperparathyroidism (PHPT) is characterized by increased calcium (Ca) and parathyroid hormone (PTH) levels. Surgical removal of the culprit hyperfunctioning parathyroid gland is the preferred treatment. In this study, we aimed to determine whether PTH-washout or cytological examination of suspicious lesions was superior in MIBI-negative patients diagnosed with PHPT.Materials and methods: We retrospectively evaluated the medical records of 98 patients diagnosed with PHPT. Seventy-six patients who had positive parathyroid scintigraphy and who did not undergo parathyroidectomy in our center due to various reasons were excluded...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29303141/synchronous-parathyroid-adenoma-and-papillary-thyroid-carcinoma-99mtc-mibi-scan-findings
#11
O Kandemir, P Atmaca Kelkit, K Karakuş
Simultaneous existence of parathyroid adenoma and thyroid nonmedullary carcinoma is rarely observed. A 52-year-old female was diagnosed approximately 4 years ago with primary hyperparathyroidism (PHPT) on the basis of hypercalcemia and elevated serum parathyroid hormone (PTH) level. Clinically, PHPT diagnosed patient was examined with Tc-99m MIBI scintigraphy to investigate parathyroid adenoma. Early Tc-99m MIBI images showed focal focused enhanced activity retention on both thyroid left lobe upper pole and thyroid lower pole inferior neighborhood...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29281866/comparative-diagnostic-performance-of-ultrasonography-and-99mtc-sestamibi-scintigraphy-for-parathyroid-adenoma-in-primary-hyperparathyroidism-systematic-review-and-meta-analysis
#12
Reza Nafisi Moghadam, Amir Pasha Amlelshahbaz, Nasim Namiranian, Mohammad Sobhan-Ardekani, Mahmood Emami-Meybodi, Ali Dehghan, Masoud Rahmanian, Seid Kazem Razavi-Ratki
Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. The search strategy was according PICO characteristics...
December 28, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29280194/effect-of-prophylactic-calcitriol-administration-on-serum-ionized-calcium-concentrations-after-parathyroidectomy-78-cases-2005-2015
#13
A J Armstrong, J G Hauptman, B J Stanley, E Klocke, M Burneko, D E Holt, J J Runge, J A Rubin
BACKGROUND: Prophylactic administration of calcitriol has been suggested to mitigate the risk of hypocalcemia after parathyroidectomy. The effect of calcitriol on postoperative serum ionized calcium concentrations has not been evaluated in dogs after parathyroidectomy. HYPOTHESIS/OBJECTIVES: To determine the effect of prophylactic calcitriol administration on postoperative serum ionized calcium (iCa) concentrations in dogs with primary hyperthyroidism (PHPTH) treated by parathyroidectomy...
December 27, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29276732/normocalcemic-primary-hyperparathyroidism-associated-with-progressive-cortical-bone-loss-a-case-report
#14
Joseph R Tucci
The existence of normocalcemic primary hyperparathyroidism (NPHP) was acknowledged at the Third and Fourth International Proceedings on primary hyperparathyroidism PHPT but data relating to its clinical presentation, natural history, and skeletal status were limited and there was no information nor guidelines as to definitive therapy. Herein are reported biochemical, hormonal, and densitometry data in a postmenopausal woman seen initially for osteoporosis who was found to have increased serum PTH levels and normal serum total and ionized calcium levels without evidence of secondary hyperparathyroidism...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29275894/ambulatory-surgery-under-local-anesthesia-for-parathyroid-adenoma-feasibility-and-outcome
#15
A Benhami, E Chuffart, N Christou, S Liva-Yonnet, M Mathonnet
The aim of this study was to evaluate the results of ambulatory parathyroid resection performed under local anesthesia (LA). MATERIAL AND METHODS: Outpatients undergoing parathyroid adenoma resection by a focused approach under LA were included. Results were evaluated by intraoperative serum parathormone levels (ioPTH) and the balance of phosphate and calcium postoperatively, at 3 months, 1 year and at the point date. The quality of ambulatory care was evaluated by the number of cancelled interventions, the number of patients hospitalized after surgery or during the first postoperative month...
December 21, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29275380/double-hit-a-unique-case-of-resistant-hypertension
#16
Kristen Elizabeth DeCarlo, Nidhi Agrawal
A middle-aged woman with obesity, hyperlipidaemia and diet-controlled diabetes was referred for resistant hypertension. Her blood pressure (BP) was uncontrolled on five medications, including a diuretic. Physical exam revealed a systolic ejection murmur, and ECHO demonstrated moderate hypertrophy. Laboratory examination revealed elevated aldosterone level (20.7 ng/dL) and elevated aldosterone:renin ratio (41.4 (ng/dL)/(ng/mL/h)), meeting criteria for primary aldosteronism (PA), and confirmed by saline infusion testing...
December 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29273178/successful-parathyroidectomy-guided-by-intraoperative-parathyroid-hormone-monitoring-for-primary-hyperparathyroidism-is-preserved-in-mild-and-moderate-renal-insufficiency
#17
Andrea R Marcadis, Richard Teo, Wenqi Ouyang, Josefina C Farrá, John I Lew
BACKGROUND: The effect of altered parathyroid hormone metabolism in renal insufficiency on intraoperative parathyroid hormone monitoring during parathyroidectomy is not well known. This study evaluates operative outcomes in patients undergoing parathyroidectomy guided by intraoperative parathyroid hormone monitoring for primary hyperparathyroidism with mild and moderate renal insufficiency. METHODS: A retrospective review of prospectively collected data in 604 patients with sporadic primary hyperparathyroidism undergoing parathyroidectomy guided by intraoperative parathyroid hormone monitoring was performed...
December 19, 2017: Surgery
https://www.readbyqxmd.com/read/29261636/prognostic-value-of-99mtc-sestamibi-parathyroid-scintigraphy-in-predicting-future-surgical-eligibility-in-patients-with-asymptomatic-primary-hyperparathyroidism
#18
Zhaoting Cheng, Sijuan Zou, Dan Peng, Guopeng Zhang, Xiaohua Zhu
PURPOSE: Patients with asymptomatic primary hyperparathyroidism might have a positive Tc-sestamibi parathyroid but do not meet criteria for surgical resection when the disease is diagnosed. However, many of these asymptomatic patients will become symptomatic or meet criteria for surgery later on. The aim of this study was to determine whether a positive sestamibi scan can precede future surgical eligibility in these patients. METHODS: This retrospective study reviewed the records of 94 asymptomatic patients who had hyperparathyroidism and underwent Tc-sestamibi study with SPECT/CT imaging...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29247451/pharmacokinetics-of-dexmedetomidine-administered-to-patients-with-end-stage-renal-failure-and-secondary-hyperparathyroidism-undergoing-general-anaesthesia
#19
W Zhong, Y Zhang, M-Z Zhang, X-H Huang, Y Li, R Li, Q-W Liu
WHAT IS KNOWN AND OBJECTIVE: The primary objective of this study was to compare the pharmacokinetics of dexmedetomidine in patients with end-stage renal failure and secondary hyperparathyroidism with those in normal individuals. METHOD: Fifteen patients with end-stage renal failure and secondary hyperparathyroidism (Renal-failure Group) and 8 patients with normal renal and parathyroid gland function (Control Group) received intravenous 0.6 μg/kg dexmedetomidine for 10 minutes before anaesthesia induction...
December 16, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29245309/value-of-preoperative-ultrasound-guided-fine-needle-aspiration-for-localization-in-tc-99m-mibi-negative-primary-hyperparathyroidism-patients
#20
Wenbo Li, Qingli Zhu, Xingjian Lai, Jian Sun, Yuxin Jiang, Xinyu Ren, Qing Zhang, Zhilan Meng, Jianchu Li, Qing Dai
To evaluate the value of preoperative ultrasound-guided fine-needle aspiration (UG-FNA) of ultrasound-detected suspicious parathyroid nodules for localization in Tc-99m MIBI-negative primary hyperparathyroidism patients.From May 2008 to December 2016, Tc-99m MIBI-negative primary hyperparathyroidism patients with ultrasound-detected suspicious cervical nodules underwent UG-FNA. The sample obtained from the solid component of the nodule was subjected to cytological evaluation and immunohistochemical staining...
December 2017: Medicine (Baltimore)
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