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https://www.readbyqxmd.com/read/29473848/bovine-%C3%AE-lactalbumin-hydrolysates-%C3%AE-lah-ameliorate-adipose-insulin-resistance-and-inflammation-in-high-fat-diet-fed-c57bl-6j-mice
#1
Jing Gao, Jiajia Song, Min Du, Xueying Mao
Obesity-induced adipose inflammation has been demonstrated to be a key cause of insulin resistance. Peptides derived from bovine α-lactalbumin have been shown to inhibit the activities of dipeptidyl peptidase IV (DPP-IV) and angiotensin converting enzyme (ACE), scavenge 2,2'-azinobis [3-ethylbenzothiazoline-6-sulfonate] (ABTS⁺) radical and stimulate glucagon-like peptide-2 secretion. In the present study, the effects of bovine α-lactalbumin hydrolysates (α-LAH) on adipose insulin resistance and inflammation induced by high-fat diet (HFD) were investigated...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29462810/consumption-of-amaranth-induces-the-accumulation-of-the-antioxidant-protein-paraoxonase-arylesterase-1-and-modulates-dipeptidyl-peptidase-iv-activity-in-plasma-of-streptozotocin-induced-hyperglycemic-rats
#2
Aída J Velarde-Salcedo, Evelyn Regalado-Rentería, Rodrigo Velarde-Salcedo, Bertha I Juárez-Flores, Alberto Barrera-Pacheco, Elvira González de Mejía, Ana P Barba de la Rosa
BACKGROUND/AIM: Amaranth is a source of several bioactive compounds, among which peptides with inhibitory activity upon dipeptidyl peptidase IV (DPP-IV) have been reported. However, there is no information about the action of amaranth DPP-IV-inhibitory peptides using in vivo models. The aim of this work was to evaluate the effect of amaranth consumption on plasma and kidney DPP-IV activity as well the changes in plasma proteome profile of streptozotocin (STZ)-induced hyperglycemic rats...
February 20, 2018: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29451201/tackling-dipeptidyl-peptidase-iv-in-neurological-disorders
#3
REVIEW
Ghaith Al-Badri, Gian Marco Leggio, Giuseppe Musumeci, Rubina Marzagalli, Filippo Drago, Alessandro Castorina
Dipeptidyl peptidase IV (DPP-IV) is a serine protease best known for its role in inactivating glucagon-like peptide-1 (GLP-1), pituitary adenylate cyclase-activating polypeptide (PACAP) and glucose-dependent insulinotropic peptide (GIP), three stimulators of pancreatic insulin secretion with beneficial effects on glucose disposal. Owing to the relationship between DPP-IV and these peptides, inhibition of DPP-IV enzyme activity is considered as an attractive treatment option for diabetic patients. Nonetheless, increasing studies support the idea that DPP-IV might also be involved in the development of neurological disorders with a neuroinflammatory component, potentially through its non-incretin activities on immune cells...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29442423/impact-of-type-1-diabetes-mellitus-and-sitagliptin-treatment-on-the-neuropeptide-y-system-of-rat-retina
#4
Elisa J Campos, João Martins, Dan Brudzewsky, Sandra Correia, Ana R Santiago, David Pd Woldbye, António F Ambrósio
BACKGROUND: Neuropeptide Y (NPY) is a neuromodulator that is expressed in the retina. Increasing evidence suggests that NPY has pronounced anti-inflammatory effects, which might depend on the inhibition of dipeptidyl-peptidase-IV (DPP-IV). The aim of this study was to investigate the impact of type 1 diabetes mellitus (DM) and sitagliptin, a DPP-IV inhibitor, on the NPY system in the retina using an animal model. METHODS: Type 1 DM was induced in male Wistar rats by an intraperitoneal injection of streptozotocin (STZ)...
February 14, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29433298/chemical-composition-and-inhibitory-activities-on-dipeptidyl-peptidase-iv-and-pancreatic-lipase-of-two-underutilized-species-from-the-brazilian-savannah-oxalis-cordata-a-st-hil-and-xylopia-aromatica-lam-mart
#5
Verena B Oliveira, Raquel L B Araújo, Thomas Eidenberger, Maria G L Brandão
Brazil has the greatest vegetal biodiversity in the world, but products derived from native species are not optimally utilized. Oxalis cordata and Xylopia aromatica are two underutilized species whose leaves and fruits, respectively, have been used as food in the 19th century. In this study, we used chemical and in vitro assays to evaluate the potential of these species as functional foods. The inhibitory activity on pancreatic lipase and DPP-IV were evaluated using the crude extracts and fractions ethyl acetate, butanol and water of these two species...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430979/an-effective-treatment-approach-of-dpp-iv-inhibitor-encapsulated-polymeric-nano-particles-conjugated-with-anti-cd-4-mab-for-type-1-diabetes
#6
Mahesh Thondawada, Ashish Devidas Wadhwani, Dhanabal S Palanisamy, Hanumant Singh Rathore, Ramesh C Gupta, Pavan Kumar Chintamaneni, Malay K Samanta, Anil Dubala, Sameer Varma, Praveen T Krishnamurthy, Kuppusamy Gowthamarajan
Nanotechnology based bio-medical approaches and surface modification techniques made it easier for targeting specific site and improving the treatment efficacy. The present study reports on targeted polymeric nanoparticles conjugated with antibody as a site-specific carrier system for effective treatment of Type 1 diabetes. Sitagliptin (SP) loaded Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NP) were prepared by nanoprecipitation cum solvent evaporation method and were characterized in terms of morphology, size, surface charge and entrapment efficiency...
February 12, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29426867/crystal-structures-of-a-bacterial-dipeptidyl-peptidase-iv-reveal-a-novel-substrate-recognition-mechanism-distinct-from-that-of-mammalian-orthologues
#7
Saori Roppongi, Yoshiyuki Suzuki, Chika Tateoka, Mayu Fujimoto, Saori Morisawa, Ippei Iizuka, Akihiro Nakamura, Nobuyuki Honma, Yosuke Shida, Wataru Ogasawara, Nobutada Tanaka, Yasumitsu Sakamoto, Takamasa Nonaka
Dipeptidyl peptidase IV (DPP IV, DPP4, or DAP IV) preferentially cleaves substrate peptides with Pro or Ala at the P1 position. The substrate recognition mechanism has been fully elucidated for mammalian DPP IV by crystal structure analyses but not for bacterial orthologues. Here, we report the crystal structures of a bacterial DPP IV (PmDAP IV) in its free form and in complexes with two kinds of dipeptides as well as with a non-peptidyl inhibitor at 1.90 to 2.47 Å resolution. Acyl-enzyme intermediates were observed for the dipeptide complexes of PmDAP IV, whereas tetrahedral intermediates were reported for the oligopeptide complexes of mammalian DPP IVs...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29412907/investigation-on-antioxidant-angiotensin-converting-enzyme-and-dipeptidyl-peptidase-iv-inhibitory-activity-of-bambara-bean-protein-hydrolysates
#8
Martin Alain Mune Mune, Samuel René Minka, Thomas Henle
Protein isolate was hydrolysed by Alcalase, thermolysin and trypsin. BBPH produced by Alcalase showed highest angiotensin-converting enzyme (ACE) inhibitory properties (IC50: 52 µg/mL). Hydrolysates produced by Alcalase and thermolysin exhibited similar dipeptidyl peptidase-IV (DPP-IV) inhibitory activity (IC50: 1.73 mg/mL), while low inhibitory activity was observed for hydrolysate produced by trypsin. BBPH also showed protective effect against oxidative stress with significant 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferrous chelating activity...
June 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29412816/tissue-expression-of-dpp-iv-in-obesity-diabetes-and-modulatory-effects-on-peptide-regulation-of-insulin-secretion
#9
Aine M McKillop, Claire L Stevenson, Brian M Moran, Yasser H A Abdel-Wahab, Peter R Flatt
Dipeptidyl peptidase type 4 (DPP-4) inhibitors represent an important class of glucose-lowering drug for type 2 diabetes. DPP-4 enzyme activity has been observed to be significantly altered in type 2 diabetes. Here, the role of DPP-4 was examined in a high fat fed (HFF) mouse model of insulin resistance. HFF mice had an increased bodyweight (p < .01), were hyperglycaemic (p < .01) and hyperinsulinaemic (p < .05). Compared to normal diet, HFF mice exhibited increased plasma DPP-4 activity (p < .01)...
February 2018: Peptides
https://www.readbyqxmd.com/read/29380955/endogenous-dipeptidyl-peptidase-iv-modulates-skeletal-muscle-arteriolar-diameter-in-rats
#10
Leslie E Neidert, Mohammed Al-Tarhuni, Daniel Goldman, Heidi A Kluess, Dwayne N Jackson
The purpose of this study is to investigate that dipeptidyl peptidase IV (DPP-IV) released from skeletal and vascular smooth muscle can increase arteriolar diameter in a skeletal muscle vascular bed by reducing neuropeptide Y (NPY)-mediated vasoconstriction. We hypothesized that the effect of myokine DPP-IV would be greatest in the smallest and least in the largest arterioles. Eight male Sprague Dawley rats (age 7-9 weeks; mass, mean ± SD: 258 ± 41 g) were anesthetized and the gluteus maximus dissected in situ for intravital microscopy analysis of arteriolar diameter of the vascular network...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29364585/what-have-we-learnt-from-real-world-data-observational-studies-and-meta-analyses
#11
REVIEW
Sudesna Chatterjee, Melanie J Davies, Kamlesh Khunti
The incretin therapies glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase-IV (DPP-IV) inhibitors are now well-established as second and third-line therapies and in combination with insulin for the treatment of type 2 diabetes. Over the last decade, there is accumulating evidence of their efficacy and safety from both large multicentre randomized clinical trials (RCT) and observational studies. Cardiovascular outcome trials have confirmed that several of these agents are also non-inferior to placebo with the GLP-1 RA liraglutide and semaglutide recently found to be superior in terms of major adverse cardiovascular events...
February 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29353063/dipeptidyl-peptidase-iv-which-probably-plays-important-roles-in-alzheimer-disease-ad-pathology-is-upregulated-in-ad-brain-neurons-and-associates-with-amyloid-plaques
#12
Hans-Gert Bernstein, Henrik Dobrowolny, Gerburg Keilhoff, Johann Steiner
There is evidence from in vitro experiments that dipeptidyl peptidase IV (DPP IV) might play role(s) in amyloid formation. However, nothing is known about the localization of the enzyme in brains of individuals with Alzheimer's disease. We herein show that in comparison to non-demented controls DPP IV is upregulated in AD brain neurons and occurs in multiple amyloid plaques.
January 16, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29341824/intestinal-lymph-as-a-readout-of-meal-induced-glp-1-release-in-an-unrestrained-rat-model
#13
Nino Jejelava, Sharon Kaufman, Jean-Philippe Krieger, Marcella Martins Terra, Wolfgang Langhans, Myrtha Arnold
Intestinal lymph supposedly provides a readout for the secretion of intestinal peptides. We here assessed how mesenteric lymph duct (MLD) lymph levels of glucagon-like peptide (GLP-1), insulin, and metabolites (Glucose, triglycerides [TG]) evolve after isocaloric high and low fat diet (HFD, LFD) meals, and how they compare to hepatic portal vein (HPV) plasma levels. Moreover, we examined the effects of intraperitoneally (IP) administered GLP-1 (1 or 10 nmol/kg) on these parameters. At 20 min after the HFD meal onset, GLP-1 levels were higher in MLD lymph than in HPV plasma...
January 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29334906/rationale-and-design-of-the-carolina%C3%A2-cognition-substudy-a-randomised-controlled-trial-on-cognitive-outcomes-of-linagliptin-versus-glimepiride-in-patients-with-type-2-diabetes-mellitus
#14
Geert Jan Biessels, Jolien Janssen, Esther van den Berg, Bernard Zinman, Mark A Espeland, Michaela Mattheus, Odd Erik Johansen
BACKGROUND: Type 2 diabetes mellitus is associated with cognitive dysfunction and an increased risk of dementia. Linagliptin is a glucose-lowering agent of the dipeptidyl peptidase-IV (DPP-IV) inhibitor class that is of particular interest for the prevention of accelerated cognitive decline, because it may potentially benefit the brain through pleiotropic effects, beyond glucose lowering. This paper presents the design of a study that aims to establish if linagliptin is superior to the sulfonylurea glimepiride in the prevention of accelerated cognitive decline in patients with type 2 diabetes mellitus...
January 15, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29274572/exploration-of-dpp-iv-inhibitors-with-a-novel-scaffold-by-multistep-in-silico-screening
#15
Taro Uchida, Masaki Wakasugi, Takahiro Kitamura, Tomomi Yamamoto, Mitsutoshi Asakura, Ryoichi Fujiwara, Tomoo Itoh, Hideaki Fujii, Shuichi Hirono
Dipeptidyl peptidase-IV (DPP-IV), an enzyme that degrades incretins-hormones that promote insulin secretion-is a therapeutic target for type 2 diabetes, with a number of its inhibitors having been launched as therapies for diabetes. Since adverse effects of these inhibitors have recently been reported, the development of novel DPP-IV inhibitors with higher efficacy and safety is required. We, therefore, screened for novel DPP-IV inhibitors using the combination of an in silico drug discovery technique and a DPP-IV assay system...
December 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29218344/generation-of-dipeptidyl-peptidase-iv-dpp-iv-inhibitory-peptides-during-the-enzymatic-hydrolysis-of-tropical-banded-cricket-gryllodes-sigillatus-proteins
#16
Alice B Nongonierma, Candice Lamoureux, Richard J FitzGerald
Tropical banded crickets (Gryllodes sigillatus) were studied for their ability to yield hydrolysates with dipeptidyl peptidase IV (DPP-IV) inhibitory properties. A cricket protein isolate (CPI) was prepared following extraction of the water soluble proteins from G. sigillatus powder (CP). The extraction yield and purity were 20.90 ± 0.35% and 57.0 ± 2.23%, respectively. Endogenous proteinase activities were detected in the CP, which were linked to the significant protein breakdown seen in this sample. Fifteen CPI hydrolysates (H1-H15) were generated with Protamex™ using a design of experiments (DOE) approach combining three parameters, temperature (40, 50 and 60 °C), enzyme to substrate ratio (E : S, 0...
December 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29207547/predicted-release-and-analysis-of-novel-ace-i-renin-and-dpp-iv-inhibitory-peptides-from-common-oat-avena-sativa-protein-hydrolysates-using-in-silico-analysis
#17
Stephen Bleakley, Maria Hayes, Nora O' Shea, Eimear Gallagher, Tomas Lafarga
The renin-angiotensin-aldosterone system (RAAS) plays an important role in regulating hypertension by controlling vasoconstriction and intravascular fluid volume. RAAS itself is largely regulated by the actions of renin (EC 3.4.23.15) and the angiotensin-I-converting enzyme (ACE-I; EC 3.4.15.1). The enzyme dipeptidyl peptidase-IV (DPP-IV; EC 3.4.14.5) also plays a role in the development of type-2 diabetes. The inhibition of the renin, ACE-I, and DPP-IV enzymes has therefore become a key therapeutic target for the treatment of hypertension and diabetes...
December 4, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29201861/active-phytochemicals-of-pueraria-tuberosa-for-dpp-iv-inhibition-in-silico-and-experimental-approach
#18
Shivani Srivastava, Priya Shree, Yamini Bhusan Tripathi
Background: We had earlier reported that the extract of Pueraria tuberosa significantly inhibits DPP-IV enzyme, resulting in glucose tolerance response in rats. In this study, we have explored the active phytochemicals responsible for this potential. The results have been validated in both fasting and postprandial states in the plasma of normal rats and also in fasting blood and intestinal homogenates of diabetic models. Methods: Pueraria tuberosa water extract (PTWE) was administered to normal Charles Foster rats for 35 days and to diabetic model (65 mg/kg bw) for 10 days...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29190734/a-novel-porphyromonas-gingivalis-enzyme-an-atypical-dipeptidyl-peptidase-iii-with-an-arm-repeat-domain
#19
Altijana Hromić-Jahjefendić, Nina Jajčanin Jozić, Saša Kazazić, Marina Grabar Branilović, Zrinka Karačić, Jörg H Schrittwieser, Krishna Mohan Padmanabha Das, Marko Tomin, Monika Oberer, Karl Gruber, Marija Abramić, Sanja Tomić
Porphyromonas gingivalis, an asaccharolytic Gram-negative oral anaerobe, is a major pathogen associated with adult periodontitis, a chronic infective disease that a significant percentage of the human population suffers from. It preferentially utilizes dipeptides as its carbon source, suggesting the importance of dipeptidyl peptidase (DPP) types of enzyme for its growth. Until now DPP IV, DPP5, 7 and 11 have been extensively investigated. Here, we report the characterization of DPP III using molecular biology, biochemical, biophysical and computational chemistry methods...
2017: PloS One
https://www.readbyqxmd.com/read/29181153/efficacy-of-alogliptin-combined-with-motor-imagery-under-hyperbaric-oxygen-in-diabetic-nephropathy-with-silent-cerebral-infarction
#20
Danyan Chen, Xiaolong Huang, Hua Gan, Xiaogang Du, Song Lu, Rongxi Huang, Ke Liu, Binghan Zhang
In the present study, we evaluated the curative effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor alogliptin combined with motor imagery under hyperbaric oxygen in diabetic nephropathy (DN) with silent cerebral infarction (SCI). Two-hundred newly diagnosed DN patients with and without SCI were included. The SCI patients were divided into two treatment groups: Alogliptin (A group, n=50) and alogliptin combined with motor imagery under hyperbaric oxygen (B group, n=50). The degrees of neurocognitive dysfunction were evaluated at baseline and after 6 months of treatment...
November 2017: Biomedical Reports
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