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https://www.readbyqxmd.com/read/29055144/increased-prevalence-of-diabetes-mellitus-in-bullous-pemphigoid-patients-during-the-last-decade
#1
Luca Fania, Giovanni Di Zenzo, Biagio Didona, Maria Antonietta Pilla, Luciano Sobrino, Annarita Panebianco, Cinzia Mazzanti, Damiano Abeni
Bullous pemphigoid (BP) is a rare autoimmune blistering disease. The association between BP and diabetes mellitus (DM) has been previously reported with inconsistent results(1-4) . Dipeptidyl peptidase (DPP)-IV inhibitors, approved in Europe by EMA in 2007 to treat type-2 DM, are antihyperglycemic drugs that could induce BP disease(5-9) . This article is protected by copyright. All rights reserved.
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29027968/rapid-identification-of-dipeptidyl-peptidase-iv-dpp-iv-inhibitory-peptides-from-ruditapes-philippinarum-hydrolysate
#2
Rui Liu, Lei Zhou, Yan Zhang, Nai-Juan Sheng, Zhi-Kang Wang, Ti-Zhi Wu, Xin-Zhi Wang, Hao Wu
Dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides were rapidly identified from Ruditapes philippinarum hydrolysate. The hydrolysate was fractionated by ethanol precipitation and preparative reverse phase high-performance liquid chromatography (RP-HPLC). The fraction which showed the highest DPP-IV inhibitory activity was then analyzed by a high-throughput nano-liquid chromatography electrospray ionization tandem mass spectrometry (nano-LC ESI-MS/MS) method, and the sequences of peptides were identified based on the MS/MS spectra against the Mollusca protein data from the UniProt database...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022103/antidiabetic-plant-derived-nutraceuticals-a-critical-review
#3
REVIEW
Jayapal Naveen, Vallikannan Baskaran
Diabetes mellitus (DM) is one of the major health problems in the world, especially amongst the urban population. Chemically synthesized drugs used to decrease the ill effects of DM and its secondary complications cause adverse side effects, viz., weight gain, gastrointestinal disturbances, and heart failure. Currently, various other approaches, viz., diet control, physical exercise and use of antidiabetic plant-derived molecules/foods are advocated to manage DM, as they are economical with fewer or no side effects...
October 11, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28915418/purification-identification-and-molecular-mechanism-of-two-dipeptidyl-peptidase-iv-dpp-iv-inhibitory-peptides-from-antarctic-krill-euphausia-superba-protein-hydrolysate
#4
Wei Ji, Chaohua Zhang, Hongwu Ji
Dipeptidyl peptidase IV (DPP-IV) played an important role in blood glucose regulation. Inhibition of DPP-IV may improve glycemic control in diabetics by preventing the rapid breakdown of incretin hormones and prolonging their physiological action. In this study, Antarctic krill (Euphausia superba) protein was hydrolyzed using animal proteolytic enzymes. The hydrolysate was purified sequentially by ultrafiltration, gel filtration chromatography and reversed phase high-performance liquid chromatography (RP-HPLC)...
October 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28892258/sitagliptin-and-roux-en-y-gastric-bypass-modulate-insulin-secretion-via-regulation-of-intra-islet-pyy
#5
Claudia Guida, Laura J McCulloch, Mahdieh Godazgar, Sam D Stephen, Charlotte Baker, Davide Basco, Jiawen Dong, Duan Chen, Anne Clark, Reshma D Ramracheya
AIMS: The gut hormone peptide tyrosine tyrosine (PYY) is critical for maintaining islet integrity and restoring islet function following Roux-en-Y gastric bypass (RYGB). The expression of PYY and its receptors (NPYRs) in islets has been documented but not fully characterized. Modulation of islet PYY by the proteolytic enzyme DPP-IV has not been investigated and the impact of DPP-IV inhibition on islet PYY function remains unexplored. Here we have addressed these gaps and their effects on glucose-stimulated insulin secretion (GSIS)...
September 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28873669/peptide-identification-in-a-salmon-gelatin-hydrolysate-with-antihypertensive-dipeptidyl-peptidase-iv-inhibitory-and-antioxidant-activities
#6
Adriana C Neves, Pádraigín A Harnedy, Martina B O'Keeffe, Monisola A Alashi, Rotimi E Aluko, Richard J FitzGerald
Salmon gelatin (Salmo salar, SG) enzymatic hydrolysates were generated using Alcalase 2.4L, Alcalase 2.4L in combination with Flavourzyme 500L, Corolase PP, Promod 144MG and Brewer's Clarex. The hydrolysate generated with Corolase PP for 1h (SG-C1) had the highest angiotensin converting enzyme (ACE, IC50=0.13±0.05mgmL(-1)) and dipeptidyl peptidase IV (DPP-IV, IC50=0.08±0.01mgmL(-1)) inhibitory activities, and oxygen radical absorbance capacity (ORAC, 540.94±9.57μmolTEg(-1)d.w.). The in vitro bioactivities of SG-C1 were retained following simulated gastrointestinal digestion...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28873655/proteomic-analysis-of-sweet-algerian-apricot-kernels-prunus-armeniaca-l-by-combinatorial-peptide-ligand-libraries-and-lc-ms-ms
#7
Hamida Ghorab, Carmen Lammi, Anna Arnoldi, Zahia Kabouche, Gilda Aiello
An investigation on the proteome of the sweet kernel of apricot, based on equalisation with combinatorial peptide ligand libraries (CPLLs), SDS-PAGE, nLC-ESI-MS/MS, and database search, permitted identifying 175 proteins. Gene ontology analysis indicated that their main molecular functions are in nucleotide binding (20.9%), hydrolase activities (10.6%), kinase activities (7%), and catalytic activity (5.6%). A protein-protein association network analysis using STRING software permitted to build an interactomic map of all detected proteins, characterised by 34 interactions...
January 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28830875/influences-of-breakfast-on-clock-gene-expression-and-postprandial-glycemia-in-healthy-individuals-and-individuals-with-diabetes-a-randomized-clinical-trial
#8
Daniela Jakubowicz, Julio Wainstein, Zohar Landau, Itamar Raz, Bo Ahren, Nava Chapnik, Tali Ganz, Miriam Menaged, Maayan Barnea, Yosefa Bar-Dayan, Oren Froy
OBJECTIVE: The circadian clock regulates glucose metabolism by mediating the activity of metabolic enzymes, hormones, and transport systems. Breakfast skipping and night eating have been associated with high HbA1c and postprandial hyperglycemia after lunch and dinner. Our aim was to explore the acute effect of breakfast consumption or omission on glucose homeostasis and clock gene expression in healthy individuals and individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS: In a cross-over design, 18 healthy volunteers and 18 volunteers with 14...
August 22, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28777292/influence-of-a-virgin-olive-oil-versus-butter-plus-cholesterol-enriched-diet-on-testicular-enzymatic-activities-in-adult-male-rats
#9
Germán Domínguez-Vías, Ana Belén Segarra, Magdalena Martínez-Cañamero, Manuel Ramírez-Sánchez, Isabel Prieto
The aim of the present work was to improve our knowledge on the mechanisms underlying the beneficial or deleterious effects on testicular function of the so-called Mediterranean and Western diet by analyzing glutamyl aminopeptidase (GluAP), gamma glutamyl transpeptidase (GGT) and dipeptidyl peptidase IV (DPP IV) activities in testis, as enzymes involved in testicular function. Male Wistar rats (6 months old) were fed for 24 weeks with three different diets: standard (S), an S diet supplemented with virgin-olive-oil (20%) (VOO), or a S diet enriched with butter (20%) plus cholesterol (0...
August 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28773977/gold-nanoparticle-based-colorimetric-and-electrochemical-methods-for-dipeptidyl-peptidase-iv-activity-assay-and-inhibitor-screening
#10
Ning Xia, Xin Wang, Xiaojin Wang, Binbin Zhou
We presented the colorimetric and electrochemical methods for determination of the dipeptidyl peptidase-IV (DPP-IV) activity and screening of its inhibitor using gold nanoparticle (AuNP) as the probe. In the colorimetric assay, the substrate peptide with a sequence of Arg-Pro-Arg induced the aggregation and color change of AuNPs, whereas cleavage of the peptide by DPP-IV prevented the aggregation of AuNPs. Furthermore, the aggregation of AuNPs in the solution was easily initiated on a solid/liquid (electrode/electrolyte) surface, which induced a decrease in the electron-transfer resistance...
October 21, 2016: Materials
https://www.readbyqxmd.com/read/28768999/characterization-of-membrane-integrity-and-morphological-stability-of-human-salivary-exosomes
#11
Nahoko Kumeda, Yuko Ogawa, Yoshihiro Akimoto, Hayato Kawakami, Masafumi Tsujimoto, Ryohei Yanoshita
Exosomes are derived from various sources, including primary and cultured cell lines and body fluids. It is now evident that they are important for communication between cells. They have, therefore, been proposed as potential carriers to deliver drugs to specific sites. In this study, we examined stability of exosomes derived from human saliva. Exosomes were stored at 4°C for up to 20 months and their membrane integrity assessed. Several exosomal markers, such as dipeptidyl peptidase IV (DPP IV; membrane marker) and programmed cell death 6-interacting protein (Alix, lumen marker), were retained intact after 20 months storage at 4°C...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28750064/modified-human-glucagon-like-peptide-1-glp-1-produced-in-e-coli-has-a-long-acting-therapeutic-effect-in-type-2-diabetic-mice
#12
Fangfang Xu, Kevin Yueju Wang, Nan Wang, Gangqiang Li, Dehu Liu
Glucagon-like peptide 1 (GLP-1) is a very potent insulinotropic hormone secreted into the blood stream after eating. Thus, it has potential to be used in therapeutic treatment of diabetes. The half-life of GLP-1, however, is very short due to its rapid cleavage by dipeptidyl peptidase IV (DPP-IV). This presents a great challenge if it is to be used as a therapeutic drug. GLP-1, like many other small peptides, is commonly produced through chemical synthesis, but is limited by cost and product quantity. In order to overcome these problems, a sequence encoding a six codon-optimized tandem repeats of modified GLP-1 was constructed and expressed in the E...
2017: PloS One
https://www.readbyqxmd.com/read/28724693/new-peptide-inhibitor-of-dipeptidyl-peptidase-iv-emdb-1-extends-the-half-life-of-glp-2-and-attenuates-colitis-in-mice-after-topical-administration
#13
Maciej Salaga, Anna Mokrowiecka, Marta Zielinska, Ewa Malecka-Panas, Radzislaw Kordek, Elzbieta Kamysz, Jakub Fichna
Protease inhibition has become a possible new approach in inflammatory bowel disease (IBD) therapy. A serine exopeptidase, dipeptidyl peptidase IV (DPP IV), is responsible for the inactivation of incretin hormone, glucagon-like peptide 2 (GLP-2), a potent stimulator of intestinal epithelium regeneration and growth. Recently, we showed that the novel peptide analog of endomorphin-2, Tyr-Pro-D-ClPhe-Phe-NH2 (EMDB-1) is a potent blocker of DPP IV and has an inhibitory effect on gastrointestinal (GI) smooth muscle contractility...
October 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28713268/sitagliptin-an-anti-diabetic-drug-suppresses-estrogen-deficiency-induced-osteoporosisin-vivo-and-inhibits-rankl-induced-osteoclast-formation-and-bone-resorption-in-vitro
#14
Chuandong Wang, Fei Xiao, Xinhua Qu, Zanjing Zhai, Guoli Hu, Xiaodong Chen, Xiaoling Zhang
Postmenopausal osteoporosis is a disease characterized by excessive osteoclastic bone resorption. Some anti-diabetic drugs were demonstrated for anti-osteoclastic bone-loss effects. The present study investigated the skeletal effects of chronic administration of sitagliptin, a dipeptidyl peptidase IV (DPP IV) inhibitor that is increasingly used for type 2 diabetes treatments, in an estrogen deficiency-induced osteoporosis and elucidated the associated mechanisms. This study indicated that sitagliptin effectively prevented ovariectomy-induced bone loss and reduced osteoclast numbers in vivo...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28711271/identification-of-dipeptidyl-peptidase-iv-inhibitory-peptides-from-mare-whey-protein-hydrolysates
#15
J J Song, Q Wang, M Du, X M Ji, X Y Mao
Inhibition of dipeptidyl peptidase-IV (DPP-IV) activity is a promising strategy for treatment of type 2 diabetes. In the current study, DPP-IV inhibitory peptides were identified from mare whey protein hydrolysates obtained by papain. The results showed that all the mare whey protein hydrolysates obtained at various hydrolysis durations possessed more potent DPP-IV inhibitory activity compared with intact whey protein. The 4-h hydrolysates showed the greatest DPP-IV inhibitory activity with half-maximal inhibitory concentration of 0...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28708310/omics-prediction-of-bioactive-peptides-from-the-edible-cyanobacterium-arthrospira-platensis-proteome
#16
Chaofan Ji, Jing Han, Jingbo Zhang, Jing Hu, Yinghuan Fu, Hang Qi, Yue Sun, Chenxu Yu
BACKGROUND: Bioinformatics approaches are widely used to evaluate the prospects of novel protein sources in bioactive peptide research. Edible cyanobacteria are considered as potential protein precursors. However, the abundance of unicellular cyanobacterial proteins is largely unknown and highly dynamic according to the cultivation conditions, which need to be considered in this research field. The objective of this work was to evaluate the protein abundance of Arthrospira platensis, as well as to map the bioactive peptide sequences from the high-abundance proteins of the A...
July 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28697993/dipeptidyl-peptidase-iv-inhibitors-as-novel-regulators-of-vascular-disease
#17
REVIEW
Ioannis Akoumianakis, Charalambos Antoniades
Dipeptidyl peptidase IV (DPP-IV) has been revealed as an adipokine with potential relevance in cardiovascular disease (CVD), while clinically used DPP-IV inhibitors have demonstrated beneficial cardiovascular effects in several experimental studies. Perivascular adipose tissue (PVAT) is a unique adipose tissue depot in close anatomical proximity and bidirectional functional interaction with the vascular wall, which is a source of DPP-IV and its biology may be influenced by DPP-IV inhibition. Recently, DPP-IV inhibition has been associated with decreased local inflammation and oxidative stress both in the vascular wall and the PVAT, potentially regulating atherogenesis progression in vivo...
September 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28692886/synthesis-and-characterization-of-oxidovanadium-complexes-as-enzyme-inhibitors-targeting-dipeptidyl-peptidase-iv
#18
Ming-Jin Xie, Ming-Rong Zhu, Chun-Mei Lu, Yi Jin, Li-Hui Gao, Ling Li, Jie Zhou, Fan-Fang Li, Qi Hua Zhao, Hong-Ke Liu, Peter J Sadler, Carlos Sanchez-Cano
Two oxidovanadium(IV) complexes carrying Schiff base ligands obtained from the condensation of 4,5-dichlorobenzene-1,2-diamine and salicylaldehyde derivatives were synthesised and characterised, including their X-ray crystallographic structures. They were evaluated as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes. These compounds were moderate inhibitors of DPP-IV, with IC50 values of ca. 40μM. In vivo tests showed that complexes 1 and 2 could lower significantly the level of glucose in the blood of alloxan-diabetic mice at doses of 22...
June 29, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28684129/chemokine-isoforms-and-processing-in-inflammation-and-immunity
#19
REVIEW
Paul Proost, Sofie Struyf, Jo Van Damme, Pierre Fiten, Estefania Ugarte-Berzal, Ghislain Opdenakker
The first dimension of chemokine heterogeneity is reflected by their discovery and purification as natural proteins. Each of those chemokines attracted a specific inflammatory leukocyte type. With the introduction of genomic technologies, a second wave of chemokine heterogeneity was established by the discovery of putative chemokine-like sequences and by demonstrating chemotactic activity of the gene products in physiological leukocyte homing. In the postgenomic era, the third dimension of chemokine heterogeneity is the description of posttranslational modifications on most chemokines...
July 3, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28619366/bpi-3016-a-novel-long-acting-hglp-1-analogue-for-the-treatment-of-type-2-diabetes-mellitus
#20
Lieming Ding, Sisi Lu, Yanping Wang, Haibo Chen, Wei Long, Cunbo Ma, Erlong He, Dan Yan, Fenlai Tan
Glucagon-like peptide-1 (GLP-1) analogues have been commonly used as add-on medications for patients with Type 2 diabetes mellitus (T2DM). Currently, the development of long-acting GLP-1 analogues which allow the freedom and flexibility of once-weekly injections while maintaining their potency for a relatively long period has become the mainstream. Here, we successfully developed a long-acting human GLP-1(7-37) analogue (BPI-3016) with significantly extended half-life and increased resistance to dipeptidyl peptidase IV (DPP-IV) cleavage by structural modifications of human GLP-1...
August 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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