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Sertraline effective dose

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https://www.readbyqxmd.com/read/28903107/dose-escalation-of-antidepressants-in-unipolar-depression-a-meta-analysis-of-double-blind-randomized-controlled-trials
#1
Markus Dold, Lucie Bartova, Rainer Rupprecht, Siegfried Kasper
BACKGROUND: As many patients with unipolar depression do not respond sufficiently to initial antidepressant monotherapy, a dose increase of the current administered antidepressant (dose escalation, high-dose treatment) is frequently carried out as next treatment measure. METHODS: We conducted a meta-analysis which included all double-blind randomized controlled trials (RCTs) comparing a dose increase of antidepressants directly to continuation of standard-dose treatment in unipolar depressive patients who were non- responders to standard-dose pharmacotherapy...
September 14, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28853392/pilot-of-a-randomised-controlled-trial-of-the-selective-serotonin-reuptake-inhibitor-sertraline-versus-cognitive-behavioural-therapy-for-anxiety-symptoms-in-people-with-generalised-anxiety-disorder-who-have-failed-to-respond-to-low-intensity-psychological-treatments
#2
Marta Buszewicz, John Cape, Marc Serfaty, Roz Shafran, Thomas Kabir, Peter Tyrer, Caroline S Clarke, Irwin Nazareth
BACKGROUND: Generalised anxiety disorder (GAD) is common, causing unpleasant symptoms and impaired functioning. The National Institute for Health and Care Excellence (NICE) guidelines have established good evidence for low-intensity psychological interventions, but a significant number of patients will not respond and require more intensive step 3 interventions, recommended as either high-intensity cognitive behavioural therapy (CBT) or a pharmacological treatment such as sertraline. However, there are no head-to-head comparisons evaluating which is more clinically effective and cost-effective, and current guidelines suggest that treatment choice at step 3 is based mainly on patient preference...
August 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28841746/-the-power-plants-of-the-cell-treatment-of-psychiatric-symptoms-in-patients-with-mitochondriopathy
#3
Sabrina Mörkl, Adelina Tmava, Claudia Blesl, Franziska Schmiedhofer, Walter E Wurm, Anna Holl, Annamaria Painold
Introduction Mitochondriopathies are pathologies of cell organelles, which are essential for the formation of adenosine triphosphate (ATP), which is responsible for cellular energy stock. When mitochondrial mutations occur, symptoms arise frequently in those organs that rely on a continuous energy supply, such as the nervous system. Although psychiatric illness is increasingly prevalent in patients with mitochondrial disease, less attention has been paid to its psychiatric presentations. Case Report We describe a case of a 21-year-old woman who presented in our outpatient department with panic attacks and depression...
August 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28783939/galactorrhea-probably-related-with-switching-from-osmotic-release-oral-system-methylphenidate-mph-to-modified-release-mph-an-adolescent-case
#4
Ozalp Ekinci, Serkan Gunes, Nuran Ekinci
Galactorrhea, as an adverse effect of psychotropic medications, usually develops due to high dose of antipsychotics. Selective serotonin reuptake inhibitors (SSRIs) have also been reported to be related to galactorrhea. To the best of our knowledge, no previous study reported galactorrhea with methylphenidate (MPH) use. Hereby, we report a case of an adolescent girl who developed galactorrhea after increasing his modifed-release oral MPH to 50 mg/day while under treatment of sertraline and very low dose haloperidol...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28759400/body-composition-in-adolescents-during-treatment-with-selective-serotonin-reuptake-inhibitors
#5
Chadi A Calarge, James A Mills, Kathleen F Janz, Trudy L Burns, William H Coryell, Babette S Zemel
OBJECTIVES: To examine the independent contribution of major depressive disorder (MDD), generalized anxiety disorder (GAD), and selective serotonin reuptake inhibitors (SSRIs) to changes in body composition in older adolescents. METHODS: Medically healthy 15- to 20-year-olds who were unmedicated or within 1 month of starting an SSRI were prospectively followed. Psychiatric functioning and medication treatment were assessed monthly. Body Mass Index (BMI) was measured every 4 months...
July 2017: Pediatrics
https://www.readbyqxmd.com/read/28708853/selective-serotonin-reuptake-inhibitors-and-venlafaxine-in-pregnancy-changes-in-drug-disposition
#6
Andreas Austgulen Westin, Malin Brekke, Espen Molden, Eirik Skogvoll, Olav Spigset
BACKGROUND: Pregnancy may cause changes in drug disposition. The clinical consequences may be profound and even counterintuitive; in some cases pregnant women may need more than twice their usual drug dose in order to maintain therapeutic drug levels. For antidepressants, evidence on drug disposition in pregnancy is scarce. The aim of this study was to determine the effects of pregnancy on serum levels of selective serotonin reuptake inhibitors (SSRIs) and venlafaxine in a large and naturalistic patient material, in order to provide tentative dose recommendations for pregnant women...
2017: PloS One
https://www.readbyqxmd.com/read/28666060/ssris-associated-with-decreased-risk-of-hepatocellular-carcinoma-a-population-based-case-control-study
#7
Hsiang-Lin Chan, Wei-Che Chiu, Vincent Chin-Hung Chen, Kuo-You Huang, Tsu-Nai Wang, Yena Lee, Roger S McIntyre, Tsai-Ching Hsu, Charles Tzu-Chi Lee, Bor-Show Tzang
BACKGROUND: Hepatocellular carcinoma (HCC) is the second leading cancer-related cause of mortality worldwide. Antidepressants, especially selective serotonin re-uptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited. OBJECTIVE: he present study aimed to investigate if the effect of all kinds of SSRIs on HCC was the same or not using population-based study. METHODS: The nationwide population-based study herein using Taiwan's National Health Insurance Research Database included a total of 59,859 cases with HCC and 285,124 matched controls...
June 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28508340/comparative-effects-of-sertraline-haloperidol-or-olanzapine-treatments-on-ketamine-induced-changes-in-mouse-behaviours
#8
O J Onaolapo, T B Paul, A Y Onaolapo
Effects of sertraline, haloperidol or olanzapine administration on ketamine-induced behaviours in mice were examined. The aim was to ascertain the degree of reversal of such behaviours by sertraline, and compare its effectiveness to haloperidol and olanzapine. Ten-week old mice (N = 120) were equally divided into main groups; 1 (open-field, radial-arm maze and elevated plus maze {EPM} tests), and 2 (social interaction test). Mice in each main group were assigned into six groups of ten (n = 10) each. Group 1 received intraperitoneal (i...
May 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28301398/a-pilot-study-cardiac-parameters-in-children-receiving-new-generation-antidepressants
#9
Mai Uchida, Andrea E Spencer, Tara Kenworthy, James Chan, Maura Fitzgerald, Ana Maria Rosales, Elana Kagan, Alexandra Saunders, Joseph Biederman
OBJECTIVE: Because of concerns about potential associations between high doses of citalopram and QTc prolongation in adults, this study examined whether such associations are operant in children. We hypothesized that therapeutic doses of nontricyclic antidepressant medications (non-TCAs) prescribed to children would be cardiovascularly safe. STUDY DESIGN: The sample consisted of 49 psychiatrically referred children and adolescents 6 to 17 years old of both sexes treated with a non-TCA (citalopram, escitalopram, fluoxetine, paroxetine, sertraline, bupropion, duloxetine, venlafaxine, mirtazapine)...
June 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28178592/sertraline-and-venlafaxine-improves-motor-performance-and-neurobehavioral-deficit-in-quinolinic-acid-induced-huntington-s-like-symptoms-in-rats-possible-neurotransmitters-modulation
#10
Jaskamal Singh Gill, Sumit Jamwal, Puneet Kumar, Rahul Deshmukh
BACKGROUND: Huntington Disease is autosomal, fatal and progressive neurodegenerative disorder for which clinically available drugs offer only symptomatic relief. Emerging strides have indicated that antidepressants improve motor performance, restore neurotransmitters level, ameliorates striatal atrophy, increases BDNF level and may enhance neurogenesis. Therefore, we investigated sertraline and venlafaxine, clinically available drugs for depression with numerous neuroprotective properties, for their beneficial effects, if any, in quinolinic acid induced Huntington's like symptoms in rats...
April 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27976631/sertraline-induced-reproductive-toxicity-in-male-rats-evaluation-of-possible-underlying-mechanisms
#11
Ozlem Atli, Merve Baysal, Gozde Aydogan-Kilic, Volkan Kilic, Seyda Ucarcan, Burak Karaduman, Sinem Ilgin
This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg-1 for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted...
December 13, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27966486/selective-serotonin-reuptake-inhibitor-sertraline-inhibits-voltage-dependent-k-channels-in-rabbit-coronary-arterial-smooth-muscle-cells
#12
Han Sol Kim, Hongliang Li, Hye Won Kim, Sung Eun Shin, Il-Whan Choi, Amy L Firth, Hyoweon Bang, Young Min Bae, Won Sun Park
We examined the effects of the selective serotonin reuptake inhibitor (SSRI) sertraline on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. Sertraline decreased the Kv channel current in a dose-dependent manner, with an IC50 value of 0.18 mu M and a slope value (Hill coefficient) of 0.61. Although the application of 1 mu M sertraline did not affect the steady-state activation curves, sertraline caused a significant, negative shift in the inactivation curves...
December 2016: Journal of Biosciences
https://www.readbyqxmd.com/read/27923359/dosage-effectiveness-and-safety-of-sertraline-treatment-for-posttraumatic-stress-disorder-in-a-japanese-clinical-setting-a-retrospective-study
#13
MULTICENTER STUDY
Toshiko Kamo, Masaharu Maeda, Misari Oe, Hiroshi Kato, Jun Shigemura, Kazuhiko Kuribayashi, Yuko Hoshino
BACKGROUND: Many of the posttraumatic stress disorder (PTSD) treatment guidelines recognize the use of selective serotonin reuptake inhibitors as first-line pharmacological treatment. In Japan, there were no published studies investigating the effectiveness and safety of sertraline for PTSD in a clinical setting. METHODS: We conducted a retrospective medical chart review of the dosage, effectiveness, and safety of sertraline for the PTSD treatment in Japan. Data were collected from medical charts of patients of PTSD, caused by various types of trauma, who were treated with sertraline between July 2006 and October 2012 during their regular clinical practice...
December 7, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27899400/study-protocol-a-phase-iii-randomised-double-blind-parallel-arm-stratified-block-randomised-placebo-controlled-trial-investigating-the-clinical-effect-and-cost-effectiveness-of-sertraline-for-the-palliative-relief-of-breathlessness-in-people-with-chronic-breathlessness
#14
Gareth J Watts, Katherine Clark, Meera Agar, Patricia M Davidson, Christine McDonald, Lawrence T Lam, Dimitar Sajkov, Nicola McCaffrey, Matthew Doogue, Amy P Abernethy, David C Currow
INTRODUCTION: Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27844092/exogenous-daytime-melatonin-modulates-response-of-adolescent-mice-in-a-repeated-unpredictable-stress-paradigm
#15
COMPARATIVE STUDY
Adejoke Yetunde Onaolapo, Ajibola Nurudeen Adebayo, Olakunle James Onaolapo
The immediate and short-term behavioural and physiological implications of exposure to stressful scenarios in the adolescent period are largely unknown; however, increases in occurrence of stress-related physiological and psychological disorders during puberty highlight the need to study substances that may modulate stress reactivity during a crucial stage of maturation. Seven groups of mice (12-15 g each) were administered distilled water (DW) (non-stressed and stressed controls), sertraline (10 mg/kg), diazepam (2 mg/kg) or one of three doses of melatonin (5, 10 and 15 mg/kg)...
February 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27825855/effect-of-co-administration-of-memantine-and-sertraline-on-the-antidepressant-like-activity-and-brain-derived-neurotrophic-factor-bdnf-levels-in-the-rat-brain
#16
Meysam Amidfar, Gislaine Z Réus, João Quevedo, Yong-Ku Kim, Mohammad Arbabi
A developing body of data has drawn attention to the N-methyl-d-aspartate (NMDA) receptor antagonists as potential drugs for the treatment of major depressive disorder (MDD). We investigated the possibility of synergistic interactions between the antidepressant sertraline with the uncompetitive NMDA receptor antagonist, memantine. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with memantine and sertraline alone or in combination in rats. To this aim, rats were chronically treated with memantine (2...
January 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/27809351/effect-of-memantine-combination-therapy-on-symptoms-in-patients-with-moderate-to-severe-depressive-disorder-randomized-double-blind-placebo-controlled-study
#17
RANDOMIZED CONTROLLED TRIAL
M Amidfar, M Khiabany, A Kohi, E Salardini, M Arbabi, M Roohi Azizi, M-R Zarrindast, P Mohammadinejad, A Zeinoddini, S Akhondzadeh
WHAT IS KNOWN AND OBJECTIVE: Current treatments for depressive disorders are far from optimum. This study was planned to evaluate possible antidepressant effects and safety of memantine, a selective N-methyl-d-aspartate receptor antagonist, in humans. METHODS: Sixty-six outpatients with the diagnosis of moderate-to-severe major depressive disorder, based on DSM-V diagnostic criteria, were recruited to participate in a parallel, randomized, controlled trial. Sixty-two participants completed 6 weeks of treatment with either memantine (20 mg/day) plus sertraline (200 mg/day) or placebo plus sertraline (200 mg/day)...
February 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27782907/garlic-induced-surgical-bleeding-how-much-is-too-much
#18
Anna Woodbury, Roman Sniecinski
A patient underwent C2-T2 decompression and fusion with excessive intraoperative bleeding and no clear source. The patient denied the use of blood-thinning medications, but had consumed the equivalent of 12 g garlic daily in the days leading up to the surgery. He was treated with desmopressin acetate (DDAVP) and cryoprecipitate with adequate control of bleeding. Garlic is known to have an antiplatelet effect, although the dose range necessary to create a bleeding abnormality has not yet been well described nor has the effect of taking garlic with sertraline or other agents with an established or potential effect on coagulation...
December 15, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27771722/inhibitory-effects-of-antidepressants-on-acetylcholine-induced-contractions-in-isolated-guinea-pig-urinary-bladder-smooth-muscle
#19
Junji Uno, Keisuke Obara, Hiroko Suzuki, Satomi Miyatani, Daisuke Chino, Takashi Yoshio, Yoshio Tanaka
BACKGROUND/AIMS: To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. METHODS: Concentration-response curves for ACh-induced contractions in guinea pig UBSM strips were obtained in the absence or presence of selected antidepressants. When inhibitory effects indicated competitive antagonism, pA2 values against ACh were calculated and compared to plausible antidepressant blood concentrations...
2017: Pharmacology
https://www.readbyqxmd.com/read/27752949/exposure-to-ssri-type-antidepressants-increases-righting-time-in-the-marine-snail-ilyanassa-obsoleta
#20
Peter P Fong, Taylor B S Bury, Elizabeth E Donovan, Olivia J Lambert, Julia R Palmucci, Stephnie K Adamczak
Exposure to human antidepressants has been shown to disrupt locomotion and other foot-mediated mechanisms in aquatic snails. We tested the effect of three selective serotonin reuptake inhibitor (SSRI)- and one selective serotonin-norepinephrine reuptake inhibitor (SNRI)-type antidepressants on the righting response in the marine snail, Ilyanassa obsoleta. All four antidepressants (fluoxetine, sertraline, paroxetine, venlafaxine) significantly increased righting time compared with controls with an exposure time as short as 1 h...
January 2017: Environmental Science and Pollution Research International
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