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Sertraline effective dose

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https://www.readbyqxmd.com/read/27923359/dosage-effectiveness-and-safety-of-sertraline-treatment-for-posttraumatic-stress-disorder-in-a-japanese-clinical-setting-a-retrospective-study
#1
Toshiko Kamo, Masaharu Maeda, Misari Oe, Hiroshi Kato, Jun Shigemura, Kazuhiko Kuribayashi, Yuko Hoshino
BACKGROUND: Many of the posttraumatic stress disorder (PTSD) treatment guidelines recognize the use of selective serotonin reuptake inhibitors as first-line pharmacological treatment. In Japan, there were no published studies investigating the effectiveness and safety of sertraline for PTSD in a clinical setting. METHODS: We conducted a retrospective medical chart review of the dosage, effectiveness, and safety of sertraline for the PTSD treatment in Japan. Data were collected from medical charts of patients of PTSD, caused by various types of trauma, who were treated with sertraline between July 2006 and October 2012 during their regular clinical practice...
December 7, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27899400/study-protocol-a-phase-iii-randomised-double-blind-parallel-arm-stratified-block-randomised-placebo-controlled-trial-investigating-the-clinical-effect-and-cost-effectiveness-of-sertraline-for-the-palliative-relief-of-breathlessness-in-people-with-chronic-breathlessness
#2
Gareth J Watts, Katherine Clark, Meera Agar, Patricia M Davidson, Christine McDonald, Lawrence T Lam, Dimitar Sajkov, Nicola McCaffrey, Matthew Doogue, Amy P Abernethy, David C Currow
INTRODUCTION: Breathlessness remains a highly prevalent and distressing symptom for many patients with progressive life-limiting illnesses. Evidence-based interventions for chronic breathlessness are limited, and there is an ongoing need for high-quality research into developing management strategies for optimal palliation of this complex symptom. Previous studies have suggested that selective serotonin reuptake inhibitors such as sertraline may have a role in reducing breathlessness...
November 29, 2016: BMJ Open
https://www.readbyqxmd.com/read/27844092/exogenous-daytime-melatonin-modulates-response-of-adolescent-mice-in-a-repeated-unpredictable-stress-paradigm
#3
Adejoke Yetunde Onaolapo, Ajibola Nurudeen Adebayo, Olakunle James Onaolapo
The immediate and short-term behavioural and physiological implications of exposure to stressful scenarios in the adolescent period are largely unknown; however, increases in occurrence of stress-related physiological and psychological disorders during puberty highlight the need to study substances that may modulate stress reactivity during a crucial stage of maturation. Seven groups of mice (12-15 g each) were administered distilled water (DW) (non-stressed and stressed controls), sertraline (10 mg/kg), diazepam (2 mg/kg) or one of three doses of melatonin (5, 10 and 15 mg/kg)...
November 14, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27825855/effect-of-co-administration-of-memantine-and-sertraline-on-the-antidepressant-like-activity-and-brain-derived-neurotrophic-factor-bdnf-levels-in-the-rat-brain
#4
Meysam Amidfar, Gislaine Z Réus, João Quevedo, Yong-Ku Kim, Mohammad Arbabi
A developing body of data has drawn attention to the N-methyl-d-aspartate (NMDA) receptor antagonists as potential drugs for the treatment of major depressive disorder (MDD). We investigated the possibility of synergistic interactions between the antidepressant sertraline with the uncompetitive NMDA receptor antagonist, memantine. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with memantine and sertraline alone or in combination in rats. To this aim, rats were chronically treated with memantine (2...
November 5, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27809351/effect-of-memantine-combination-therapy-on-symptoms-in-patients-with-moderate-to-severe-depressive-disorder-randomized-double-blind-placebo-controlled-study
#5
M Amidfar, M Khiabany, A Kohi, E Salardini, M Arbabi, M Roohi Azizi, M-R Zarrindast, P Mohammadinejad, A Zeinoddini, S Akhondzadeh
WHAT IS KNOWN AND OBJECTIVE: Current treatments for depressive disorders are far from optimum. This study was planned to evaluate possible antidepressant effects and safety of memantine, a selective N-methyl-d-aspartate receptor antagonist, in humans. METHODS: Sixty-six outpatients with the diagnosis of moderate-to-severe major depressive disorder, based on DSM-V diagnostic criteria, were recruited to participate in a parallel, randomized, controlled trial. Sixty-two participants completed 6 weeks of treatment with either memantine (20 mg/day) plus sertraline (200 mg/day) or placebo plus sertraline (200 mg/day)...
November 3, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27782907/garlic-induced-surgical-bleeding-how-much-is-too-much
#6
Anna Woodbury, Roman Sniecinski
A patient underwent C2-T2 decompression and fusion with excessive intraoperative bleeding and no clear source. The patient denied the use of blood-thinning medications, but had consumed the equivalent of 12 g garlic daily in the days leading up to the surgery. He was treated with desmopressin acetate (DDAVP) and cryoprecipitate with adequate control of bleeding. Garlic is known to have an antiplatelet effect, although the dose range necessary to create a bleeding abnormality has not yet been well described nor has the effect of taking garlic with sertraline or other agents with an established or potential effect on coagulation...
October 24, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27771722/inhibitory-effects-of-antidepressants-on-acetylcholine-induced-contractions-in-isolated-guinea-pig-urinary-bladder-smooth-muscle
#7
Junji Uno, Keisuke Obara, Hiroko Suzuki, Satomi Miyatani, Daisuke Chino, Takashi Yoshio, Yoshio Tanaka
BACKGROUND/AIMS: To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. METHODS: Concentration-response curves for ACh-induced contractions in guinea pig UBSM strips were obtained in the absence or presence of selected antidepressants. When inhibitory effects indicated competitive antagonism, pA2 values against ACh were calculated and compared to plausible antidepressant blood concentrations...
October 22, 2016: Pharmacology
https://www.readbyqxmd.com/read/27752949/exposure-to-ssri-type-antidepressants-increases-righting-time-in-the-marine-snail-ilyanassa-obsoleta
#8
Peter P Fong, Taylor B S Bury, Elizabeth E Donovan, Olivia J Lambert, Julia R Palmucci, Stephnie K Adamczak
Exposure to human antidepressants has been shown to disrupt locomotion and other foot-mediated mechanisms in aquatic snails. We tested the effect of three selective serotonin reuptake inhibitor (SSRI)- and one selective serotonin-norepinephrine reuptake inhibitor (SNRI)-type antidepressants on the righting response in the marine snail, Ilyanassa obsoleta. All four antidepressants (fluoxetine, sertraline, paroxetine, venlafaxine) significantly increased righting time compared with controls with an exposure time as short as 1 h...
October 17, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27736049/high-dose-citalopram-and-escitalopram-and-the-risk-of-out-of-hospital-death
#9
Wayne A Ray, Cecilia P Chung, Katherine T Murray, Kathi Hall, C Michael Stein
OBJECTIVE: Studies demonstrating that higher doses of citalopram (> 40 mg) and escitalopram (> 20 mg) prolong the corrected QT interval prompted regulatory agency warnings, which are controversial, given the absence of confirmatory clinical outcome studies. We compared the risk of potential arrhythmia-related deaths for high doses of these selective serotonin reuptake inhibitors (SSRIs) to that for equivalent doses of fluoxetine, paroxetine, and sertraline. METHODS: The Tennessee Medicaid retrospective cohort study included 54,220 persons 30-74 years of age without cancer or other life-threatening illness who were prescribed high-dose SSRIs from 1998 through 2011...
October 11, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27703829/development-of-tinnitus-at-a-low-dose-of-sertraline-clinical-course-and-proposed-mechanisms
#10
Christopher W T Miller
Introduction. Serotonin is involved in filtering of auditory stimuli. Cochlear input is processed through complex interactions between serotonergic, glutamatergic, and GABAergic neurotransmitter systems. Options for treatment of tinnitus include selective serotonin reuptake inhibitors (SSRIs); however in rare instances this symptom may occur as a side effect of this class of medications. Case Presentation. A 50-year-old woman developed bilateral tinnitus after several weeks of being treated with sertraline 50 mg...
2016: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/27590831/the-impact-of-treatment-with-selective-serotonin-reuptake-inhibitors-on-primate-cardiovascular-disease-behavior-and-neuroanatomy
#11
Carol A Shively, Marnie Silverstein-Metzler, Jamie Justice, Stephanie L Willard
Selective serotonin reuptake inhibitor (SSRI) use is ubiquitous because they are widely prescribed for a number of disorders in addition to depression. Depression increases the risk of coronary heart disease (CHD). Hence, treating depression with SSRIs could reduce CHD risk. However, the effects of long term antidepressant treatment on CHD risk, as well as other aspects of health, remain poorly understood. Thus, we undertook an investigation of multisystem effects of SSRI treatment with a physiologically relevant dose in middle-aged adult female cynomolgus monkeys, a primate species shown to be a useful model of both depression and coronary and carotid artery atherosclerosis...
August 30, 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27572627/effects-of-sertraline-duloxetine-vortioxetine-and-idazoxan-in-the-rat-affective-bias-test
#12
Louise K Refsgaard, Kia Haubro, Darryl S Pickering, Sarah A Stuart, Emma S J Robinson, Jesper T Andreasen
RATIONALE: Affective biases seemingly play a crucial role for the onset and development of depression. Acute treatment with monoamine-based antidepressants positively influences emotional processing, and an early correction of biases likely results in repeated positive experiences that ultimately lead to improved mood. OBJECTIVES: Using two conventional antidepressants, sertraline and duloxetine, we aimed to forward the characterization of a newly developed affective bias test (ABT) for rats...
October 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27560971/a-randomized-double-blind-placebo-controlled-trial-of-low-dose-sertraline-in-young-children-with-fragile-x-syndrome
#13
Laura Greiss Hess, Sarah E Fitzpatrick, Danh V Nguyen, Yanjun Chen, Kimberly N Gaul, Andrea Schneider, Kerrie Lemons Chitwood, Marwa Abd Al Azaim Eldeeb, Jonathan Polussa, David Hessl, Susan Rivera, Randi J Hagerman
OBJECTIVE: Observational studies and anecdotal reports suggest that sertraline, a selective serotonin reuptake inhibitor, may improve language development in young children with fragile X syndrome (FXS). METHODS: The authors evaluated the efficacy of 6 months of treatment with low-dose sertraline in a randomized, double-blind, placebo-controlled trial in 52 children with FXS aged 2 to 6 years. RESULTS: Eighty-one subjects were screened for eligibility, and 57 were randomized to sertraline (27) or placebo (30)...
October 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27271860/a-mega-analysis-of-fixed-dose-trials-reveals-dose-dependency-and-a-rapid-onset-of-action-for-the-antidepressant-effect-of-three-selective-serotonin-reuptake-inhibitors
#14
F Hieronymus, S Nilsson, E Eriksson
The possible dose-dependency for the antidepressant effect of selective serotonin reuptake inhibitors (SSRIs) remains controversial. We believe we have conducted the first comprehensive patient-level mega-analysis exploring this issue, one incentive being to address the possibility that inclusion of low-dose arms in previous meta-analyses may have caused an underestimation of the efficacy of these drugs. All company-sponsored, acute-phase, placebo-controlled, fixed-dose trials using the Hamilton Depression Rating Scale (HDRS) and conducted to evaluate the effect of citalopram, paroxetine or sertraline in adult major depression were included (11 trials, n=2859 patients)...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27021092/comparison-of-the-efficiency-of-adeprophen-and-antidepressants-of-various-groups-on-the-model-of-reserpine-induced-depression-in-rats
#15
A A Ozerov, V V Bagmetova, Yu V Chernysheva, I N Tyurenkov
A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally). This effect manifested in suppression of depression-like behavior in the Porsolt forced swimming test (shortening of immobility time and increase in immobility latency, number of jumping episodes, and time of active swimming) and sucrose consumption/preference test (increase in the consumption of 20% sucrose solution in g/100 g body weight and percentage of sucrose preference in relation to the total fluid preference)...
March 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26872137/phytochemical-screening-antidepressant-and-analgesic-effects-of-aqueous-extract-of-anethum-graveolens-l-from-southeast-of-morocco
#16
Latifa El Mansouri, Dalila Bousta, Amal El Youbi-El Hamsas, Smahane Boukhira, Hassane Akdime
This study aims to investigate the antidepressant and analgesic properties of the aqueous extract of Anethum graveolens L. from South of Morocco (Rissani-Errachidia region). Extract of plant is obtained by aqueous decoction and administered to Wistar rats orally. The extract has a significant antidepressant and analgesic effects compared with the drug references (sertraline and tramadol) without any adverse effects. The dose of 250 mg/kg, body weight shows the best antidepressant and analgesic effects than 1 g/kg, body weight...
February 11, 2016: American Journal of Therapeutics
https://www.readbyqxmd.com/read/26830411/influence-of-cyp2b6-and-cyp2c19-polymorphisms-on-sertraline-metabolism-in-major-depression-patients
#17
Nazan Yuce-Artun, Bora Baskak, Erguvan Tugba Ozel-Kizil, Hatice Ozdemir, Zuhal Uckun, Halise Devrimci-Ozguven, Halit Sinan Suzen
BACKGROUND: Genetic polymorphisms in CYP2B6 and CYP2C19 may cause variability in the metabolism of sertraline, a widely used antidepressant in major depressive disorder treatment. OBJECTIVE: This study investigates the impact of CYP2B6*4 (785A > G), CYP2B6*9 (516G > T), CYP2B6*6 (516G > T + 685G > A) CYP2C19*2 (685G > A), CYP2C19*17 (-3402C > T) polymorphisms on plasma concentrations of sertraline and N-desmethyl sertraline in major depression patients treated with sertraline [n = 50]...
April 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/26830290/effect-of-the-anti-depressant-sertraline-the-novel-anti-seizure-drug-vinpocetine-and-several-conventional-antiepileptic-drugs-on-the-epileptiform-eeg-activity-induced-by-4-aminopyridine
#18
Maria Sitges, Blanca Irene Aldana, Ronald Charles Reed
Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sertraline, and the anti-seizure drug vinpocetine are effective inhibitors of cerebral presynaptic Na(+) channels. Here the effectiveness of these compounds to prevent the epileptiform EEG activity induced by 4-AP was compared with the effectiveness of seven conventional antiepileptic drugs...
June 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26738329/-efficacy-of-shugan-yiyang-capsules-combined-with-sertraline-on-premature-ejaculation
#19
RANDOMIZED CONTROLLED TRIAL
Xiao-wei Wu, Yu-yan Zeng
OBJECTIVE: To observe the clinical effect of Shugan Yiyang Capsules combined with sertraline in the treatment of premature ejaculation (PE). METHODS: We randomly assigned 192 PE patients to receive sertraline hydrochloride 50 mg qd (control group, n = 96) or sertraline hydrochloride 50 mg qd plus Shugan Yiyang Capsules at the dose of 4 capsules tid ( combination therapy group, n = 96) , both for 6 weeks. We compared the intravaginal ejaculatory latency time (IELT) and Chinese Index of Premature Ejaculation ( CIPE) scores between the two groups of patients before and after medication and at 6 weeks after drug withdrawal...
November 2015: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/26731026/-the-usefulness-of-clonazepam-as-an-augmentative-treatment-in-a-case-of-severe-childhood-onset-obsessive-compulsive-disorder
#20
Soumeyya Halayem, Sami Othman, Hajer Ben Youssef, Ahlem Belhaj, Anissa Bouasker, Rym Ghachem, Karim Tabbane, Asma Bouden
The goal of this study is to report on the treatment of obsessive-compulsive disorder (OCD), a chronic disabling condition that often presents during childhood and adolescence. Reports on adults using clonazepam for the treatment of OCD are more numerous than on children. Clonazepam as an augmentative treatment in OCD is still controversial. Our aim is to illustrate in a case report the efficacy of clonazepam as an augmentative treatment for severe childhood onset OCD. We report on the case of a young teenage girl with an extremely severe form of obsessive-compulsive disorder (score of 32 on the Children's Yale-Brown Obsessive Compulsive Scale), who, after a mild improvement with a combination of serotonin recapture inhibitors and second generation antipsychotics at high doses, has responded to clonazepam (3mg/day) augmentation of sertraline (200mg/day) and olanzapine (15mg/day)...
2015: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
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