keyword
https://read.qxmd.com/read/38492067/short-term-outcomes-of-robot-assisted-versus-conventional-minimally-invasive-esophagectomy-for-esophageal-cancer-a-systematic-review-and-meta-analysis-of-18-187-patients
#21
REVIEW
Rui Perry, José Pedro Barbosa, Isabel Perry, José Barbosa
The role of robotic surgery in the curative-intent treatment of esophageal cancer patients is yet to be defined. To compare short-term outcomes between conventional minimally invasive (cMIE) and robot-assisted minimally invasive esophagectomy (RAMIE) in esophageal cancer patients. PubMed, Web of Science and Cochrane Library were systematically searched. The included studies compared short-term outcomes between cMIE and RAMIE. Individual risk of bias was calculated using the MINORS and RoB2 scales. There were no statistically significant differences between RAMIE and cMIE regarding conversion to open procedure, mean number of harvested lymph nodes in the mediastinum, abdomen and along the right recurrent laryngeal nerve (RLN), 30- and 90-day mortality rates, chyle leakage, RLN palsy as well as cardiac and infectious complication rates...
March 16, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38491472/thoracoscopic-mckeown-esophagectomy-in-a-patient-with-an-azygos-lobe
#22
JOURNAL ARTICLE
Rie Nakashima, Kohei Tajima, Kazuo Koyanagi, Akihito Kazuno, Miho Yamamoto, Yoshiaki Shoji, Kentaro Yatabe, Kohei Kanamori, Mika Ogimi, Kazuhito Nabeshima, Kenji Nakamura, Masaki Mori
BACKGROUND: The azygos lobe is a relatively rare anatomical variation, and there have been no reports, until date, of thoracoscopic McKeown esophagectomy for esophageal cancer in a patient with an azygos lobe. The azygos lobe can be diagnosed by chest X-ray or CT, and is usually not associated with any symptoms. However, surgeons should be aware that transthoracic surgical procedures in patients with an azygos lobe could be associated with a high risk of complications. CASE PRESENTATION: An 83-years-old man was brought to our emergency room with fever, severe headache, and difficulty in moving...
March 15, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38490752/miro-study-do-the-results-of-a-randomized-controlled-trial-apply-in-a-real-population
#23
JOURNAL ARTICLE
Alexandre Challine, Mehdi Kirouani, Sheraz R Markar, Stylianos Tzedakis, Romain Jaquet, Guillaume Piessen, Tienhan Sandrine Dabakoyo-Yonli, Jérémie H Lefèvre, Andrea Lazzati, Thibault Voron
BACKGROUND: The aim of our study was to evaluate the external validity of the MIRO randomized controlled trial findings in a similar nationwide setting "real life" population, especially the benefit of a hybrid approach in esophageal resection for pulmonary complication. The external validity of randomized controlled trial findings to the general population with the same condition remains problematic because of the inherent selection bias and rigid inclusion criteria. METHODS: This study was a cohort study from a National Health Database (Programme de Medicalisation des Systemes d'Informations) between 2010 and 2022...
April 2024: Surgery
https://read.qxmd.com/read/38489728/clinical-responses-to-vemurafenib-in-postoperative-recurrence-of-papillary-thyroid-carcinoma-with-esophageal-fistula-a-case-report
#24
JOURNAL ARTICLE
Sicheng He, Wei Lu, Xun Ding, Jun Zhou, Di Liu, Yang Zhu, Fugang Yang, Zanmei Fu
BACKGROUND: While papillary thyroid carcinoma (PTC) generally exhibits a favorable prognosis post-surgery, the poorly differentiated subtype presents elevated rates of postoperative recurrence. Certain aggressive cases demonstrate invasive behavior, compromising adjacent structures and leading to a poor prognosis. This study delineates a unique case of postoperative PTC recurrence, complicated by esophageal fistula, that showed favorable outcomes following brief Vemurafenib treatment...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38485881/treatment-strategy-for-early-stage-esophageal-cancer
#25
REVIEW
Katsuyuki Sakanaka
Approximately 90% of esophageal cancers in Japan are squamous cell carcinomas, and they are often detected at earlier stages in Japan than in Western countries; superficial esophageal cancer without lymph node or distant metastasis comprises one-third of all esophageal cancers in Japan. Endoscopic resection is a minimally invasive treatment for superficial esophageal cancer; however, the risk of regional lymph node recurrence is negligible when it invades the submucosal layer or lymphovasculature. In such cases, surgical treatment is necessary to control regional lymph node recurrences, although the physical burdens and potential complications cannot be overlooked...
March 15, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38485552/esophagogastric-cancer-the-current-role-of-radiation-therapy
#26
REVIEW
Leila T Tchelebi, Karyn A Goodman
Radiation therapy is an effective treatment modality in the management of patients with esophageal cancer regardless of tumor location (proximal, middle, or distal esophagus) or histology (squamous cell vs adenocarcinoma). The addition of neoadjuvant CRT to surgery in patients who are surgical candidates has consistently shown a benefit in terms of locoregional recurrence, pathologic downstaging, and overall survival. For patients who are not surgical candidates, CRT has a role as definitive treatment.
March 13, 2024: Hematology/oncology Clinics of North America
https://read.qxmd.com/read/38483131/locally-advanced-adenocarcinoma-of-the-esophagus-is-esophagectomy-associated-with-improved-overall-survival
#27
JOURNAL ARTICLE
Sarah P Kramer, James Swanson, Mitchel Fernando, Simon Park, Raymond Verm, Zaid Abdelsattar, Tyler Cohn, Fred A Luchette, Marshall S Baker
BACKGROUND: Esophagectomy in locally advanced esophageal adenocarcinoma is challenging and carries risk. The value of esophagectomy in locally advanced esophageal adenocarcinoma is not well-defined. STUDY DESIGN: The National Cancer Database was used to identify patients with cT4 esophageal adenocarcinoma from 2004-2020. Multivariable regression was used to identify factors associated with use of esophagectomy. Cox modeling was used to identify factors associated with all-cause mortality...
March 14, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38480565/is-robotic-surgery-the-future-for-resectable-esophageal-cancer-a-systematic-literature-review-of-oncological-and-clinical-outcomes
#28
JOURNAL ARTICLE
Nikhil Manish Patel, Pranav Harshad Patel, Kai Tai Derek Yeung, David Monk, Borzoueh Mohammadi, Muntzer Mughal, Ricky Harminder Bhogal, William Allum, Nima Abbassi-Ghadi, Sacheen Kumar
BACKGROUND: Radical esophagectomy for resectable esophageal cancer is a major surgical intervention, associated with considerable postoperative morbidity. The introduction of robotic surgical platforms in esophagectomy may enhance advantages of minimally invasive surgery enabled by laparoscopy and thoracoscopy, including reduced postoperative pain and pulmonary complications. This systematic review aims to assess the clinical and oncological benefits of robot-assisted esophagectomy. METHODS: A systematic literature search of the MEDLINE (PubMed), Embase and Cochrane databases was performed for studies published up to 1 August 2023...
March 13, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38479934/malnutrition-and-vitamin-deficiencies-after-surgery-for-esophageal-and-gastric-cancer-a-metanalysis
#29
JOURNAL ARTICLE
Alida Finze, Guy Hej Vijgen, Johanna Betzler, Vanessa Orth, Svetlana Hetjens, Christoph Reissfelder, Mirko Otto, Susanne Blank
BACKGROUND & AIMS: Patients receiving oncological esophagectomy or gastrectomy are known to be at high risk for vitamin and micronutrient deficiency before, during and after surgery. However, there are no clear guidelines for these cancer patients regarding postoperative vitamin supplementation. METHODS: We conducted a metanalysis consisting of 10 studies regarding vitamin and micronutrient deficiencies after oncological gastric or esophageal resection. 5 databases were searched...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38479623/endoscopic-submucosal-dissection-for-early-esophageal-adenocarcinoma-low-rates-of-metastases-in-mucosal-cancers-with-poor-differentiation
#30
JOURNAL ARTICLE
Andreas Probst, Felix Kappler, Alanna Ebigbo, David Albers, Siegbert Faiss, Ingo Steinbrück, Andreas Wannhoff, Hans-Peter Allgaier, Ulrike Denzer, Viktor Rempel, Roland Reinehr, Dani Dakkak, Matthias Mende, Jürgen Pohl, Tina Schaller, Bruno Märkl, Anna Muzalyova, Carola Fleischmann, Helmut Messmann
BACKGROUND AND AIMS: Endoscopic resection (ER) is accepted as standard treatment for intramucosal esophageal adenocarcinoma (EAC) with well or moderate differentiation. Poor differentiation (PD) is judged as a risk factor for lymph node metastasis (LNM) and surgery is recommended. However, the evidence for this recommendation is weak. Study aim was to analyze the clinical course of patients after ER of EAC with PD. PATIENTS AND METHODS: Patients undergoing endoscopic submucosal dissection for EAC were included from 16 German centers...
March 11, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38477511/nomogram-for-predicting-pathologic-complete-response-to-neoadjuvant-chemoradiotherapy-in-patients-with-esophageal-squamous-cell-carcinoma
#31
JOURNAL ARTICLE
Guihong Liu, Tao Chen, Xin Zhang, Binbin Hu, Jiayun Yu
PURPOSE: A pathologic complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) is seen in up to 40% of the patients with esophageal squamous cell carcinoma (ESCC). No nomogram has been constructed for the prediction of pCR for patients whose primary chemotherapy was a taxane-based regimen. The aim is to identify characteristics associated with a pCR through analyzing multiple pre- and post-nCRT variables and to develop a nomogram for the prediction of pCR for these patients by integrating clinicopathological characteristics and hematological biomarkers...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38477129/combined-resection-for-synchronous-lung-lesions-and-esophageal-cancer-should-be-compared-with-staged-surgery
#32
JOURNAL ARTICLE
Kexun Li, Jie Zhao, Zhenghong Yang, Jie Mao, Yunchao Huang
No abstract text is available yet for this article.
March 12, 2024: International Journal of Surgery
https://read.qxmd.com/read/38476207/esophageal-squamous-cell-carcinoma-transformed-into-neuroendocrine-carcinoma-after-neoadjuvant-immunochemotherapy-a-case-report
#33
Gaojie Xin, Naicheng Song, Ke Jiang
Immunotherapy provides durable responses for locally advanced esophageal carcinoma clinical therapy in numerous patients. However, the mechanisms of resistance to immunotherapy have not been elucidated. The phenomenon of the histological transformation of non-small cell lung cancer to small cell lung cancer resulting in resistance to immune checkpoint inhibitors (ICIs) has been reported. It remains unclear whether ICIs or chemotherapy could cause a similar transformation from esophageal squamous cell carcinoma (ESCC) to esophageal neuroendocrine carcinoma (ENEC)...
April 2024: Oncology Letters
https://read.qxmd.com/read/38473310/false-liver-metastasis-by-positron-emission-tomography-computed-tomography-scan-after-chemoradiotherapy-for-esophageal-cancer-potential-overstaged-pitfalls-of-treatment
#34
REVIEW
Sen-Ei Shai, Yi-Ling Lai, Chen-I Chang, Chi-Wei Hsieh
In patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy (nCRT), subsequent restaging with F-18-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) can reveal the presence of interval metastases, such as liver metastases, in approximately 10% of cases. Nevertheless, it is not uncommon in clinical practice to observe focal FDG uptake in the liver that is not associated with liver metastases but rather with radiation-induced liver injury (RILI), which can result in the overstaging of the disease...
February 26, 2024: Cancers
https://read.qxmd.com/read/38470437/calcifications-in-the-descending-thoracic-aorta-predict-postoperative-anastomotic-leakages-after-esophagectomy-for-cancer
#35
JOURNAL ARTICLE
Emma Tiainen, Erkki-Ville Wirta, Tuula Tyrväinen, Tommi Kuorilehto, Vesa Toikkanen, Johanna Laukkarinen, Mika Ukkonen
BACKGROUND: Anastomotic leak is one of the most feared complications of esophagectomy. Previous studies have suggested a potential link between aortic calcifications detected on routine preoperative CT scans and increased risk of anastomotic leak after esophagectomy. This study aims to investigate whether clinicians' assessment of aortic calcifications can predict the occurrence of anastomotic leaks in patients undergoing esophagectomy for cancer. METHODS: A long-term follow-up was conducted on consecutive patients with esophageal cancer who underwent elective open esophagectomy at a Finnish tertiary hospital...
March 12, 2024: World Journal of Surgery
https://read.qxmd.com/read/38467897/esophageal-cancer-in-an-adult-with-congenital-esophageal-stenosis-a-case-report
#36
JOURNAL ARTICLE
Yushi Fujiwara, Hidehiko Kitagami, Tomohiro Kikkawa, Keita Sakashita, Takaya Kusumi, Yasunori Nishida
BACKGROUND: Congenital esophageal stenosis (CES) is a rare condition. We encountered a case of esophageal cancer that developed in an adult with persistent CES. Although many studies have investigated the therapeutic outcomes and performed surveillance for symptoms after treatment for CES, few have performed long-term surveillance or reported on the development of esophageal cancer. We report this case because it is extremely rare and has important implications. CASE PRESENTATION: A 45-year-old woman with worsening dysphagia was transferred to our hospital...
March 12, 2024: Surgical Case Reports
https://read.qxmd.com/read/38464816/comparative-efficacy-and-safety-between-endoscopic-submucosal-dissection-surgery-and-definitive-chemoradiotherapy-in-patients-with-ct1n0m0-esophageal-cancer
#37
JOURNAL ARTICLE
Shu-Ai Luo, Yu-Ying Sun, Ya-Ting Zeng, Chun-Yu Huang
BACKGROUND: Endoscopic submucosal dissection (ESD) and surgical resection are the standard of care for cT1N0M0 esophageal cancer (EC), whereas definitive chemoradiotherapy (d-CRT) is a treatment option. Nevertheless, the comparative efficiency and safety of ESD, surgery and d-CRT for cT1N0M0 EC remain unclear. AIM: To compare the efficiency and safety of ESD, surgery and d-CRT for cT1N0M0 EC. METHODS: We retrospectively analyzed the hospitalized data of a total of 472 consecutive patients with cT1N0M0 EC treated at Sun Yat-sen University Cancer center between 2017-2019 and followed up until October 30th, 2022...
February 16, 2024: World Journal of Gastrointestinal Endoscopy
https://read.qxmd.com/read/38462149/multi-disciplinary-management-of-esophageal-carcinoma-current-practices-and-future-directions
#38
REVIEW
Chanyoot Bandidwattanawong
Esophageal cancer in one of the most malignant and hard-to-treat cancers. Esophageal squamous carcinoma (ESCC) is most common in Asian countries, whereas adenocarcinoma at the esophago-gastric junction (EGJ AC) is more prevalent in the Western countries. Due to differences in both genetic background and response to chemotherapy and radiotherapy, both histologic subtypes need different paradigms of management. Since the landmark CROSS study has demonstrated the superior survival benefit of tri-modality including neoadjuvant chemoradiotherapy prior to esophagectomy, the tri-modality becomes the standard of care; however, it is suitable for a highly-selected patient...
March 8, 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/38460292/secondary-amenorrhea-as-the-first-presentation-of-krukenberg-tumor-arising-from-the-gastroesophageal-junction-in-a-34-year-old-woman-a-case-report
#39
Bassam Hassan, Lava Abdullah, Firas Hussein, Aghiad Issa, Thanaa Al-Assi, Zuheir Alshehabi
INTRODUCTION: Krukenberg tumors account for 9 % of metastatic ovarian tumors, they usually originate from the stomach and colon and are microscopically characterized by the presence of mucus-filled signet-ring cells. Krukenberg tumor originating from the gastroesophageal junction is extremely rare, which limits establishing proper diagnosis and management. PRESENTATION OF CASE: A 34-year-old women presented with a complaint of amenorrhea, ultrasonography showed bilateral ovarian masses, pathological studies revealed Krukenberg tumor, immunohistochemistry of the tumor was positive for (CK1, and CK20)...
March 1, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38458635/neoadjuvant-chemoradiotherapy-combined-with-sequential-perioperative-toripalimab-in-locally-advanced-esophageal-squamous-cell-cancer
#40
JOURNAL ARTICLE
Xin Xu, Zhiyong Sun, Qiang Liu, Yao Zhang, Lei Shen, Chenpeng Zhang, Haiping Lin, Bin Hu, Ling Rong, Haiyan Chen, Xiaohang Wang, Xiaojing Zhao, Yong-Rui Bai, Qing Ye, Xiumei Ma
BACKGROUND: Programmed death 1 (PD-1) inhibitor demonstrated durable antitumor activity in advanced esophageal squamous cell carcinoma (ESCC), but the clinical benefit of perioperative immunotherapy in ESCC remains unclear. This study evaluated the efficacy and safety of neoadjuvant chemoradiotherapy (nCRT) combined with the PD-1 inhibitor toripalimab in patients with resectable ESCC. METHODS: From July 2020 to July 2022, 21 patients with histopathologically confirmed thoracic ESCC and clinical staged as cT1-4aN1-2M0/cT3-4aN0M0 were enrolled...
March 7, 2024: Journal for Immunotherapy of Cancer
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