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Esophageal cancer surgery

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https://www.readbyqxmd.com/read/28900998/-associated-factors-of-postoperative-relapse-and-metastasis-in-pt1bn0m0-pt4an0m0-thoracic-esophageal-squamous-cell-carcinoma
#1
Wenbiao Pan, Yangwei Xiang, Zhitao Gu, Chunyu Ji, Teng Mao, Wentao Fang
OBJECTIVE: To investigate the associated high risk factors of postoperative relapse and metastasis for patients with confined tumors (grade pT1b-4a) without lymph-node metastases (pN0) in thoracic esophageal squamous cell carcinoma (ESCC). METHODS: Clinicopathological and follow up data of ESCC patients undergoing radical surgical resection as primary treatment in the Department of Thoracic Surgery, Shanghai Chest Hospital between January 2004 and December 2012 from Hospital Database were retrospectively collected...
September 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28892265/effects-of-preemptive-analgesia-with-flurbiprofen-ester-on-lymphocytes-and-natural-killer-cells-in-patients-undergoing-esophagectomy-a-randomized-controlled-pilot-study
#2
Yi Zhou, Jinxi Huang, Yu Bai, Changsheng Li, Xihua Lu
BACKGROUND: Tumors may induce systemic immune dysfunction, which can be aggravated by surgery and anesthesia/analgesia. Data on the effect of flurbiprofen preemptive analgesia on immune dysfunction is limited. The aim of this study was to investigate the effect of flurbiprofen preemptive analgesia on lymphocytes and natural killer (NK) cells in patients undergoing thoracotomy and thoracoscopy radical esophagectomy, and to explore the analgesic methods suitable for tumor patients. METHODS: This was a randomized controlled pilot study of 89 patients with esophageal cancer treated with surgery at the Henan Cancer Hospital between January 1, 2015 and December 31, 2016...
September 11, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28887066/neoadjuvant-chemoradiation-is-associated-with-improved-overall-survival-in-older-patients-with-esophageal-cancer
#3
David M Guttmann, Nandita Mitra, James M Metz, John Plastaras, Weiwei Feng, Samuel Swisher-McClure
OBJECTIVES: The aim of this study was to characterize outcomes associated with neoadjuvant chemoradiation prior to esophagectomy, compared to esophagectomy alone, in older patients with esophageal cancer. MATERIALS AND METHODS: We conducted an observational cohort study in patients ≥70years with locally-advanced esophageal cancer undergoing esophagectomy ± neoadjuvant chemoradiation between 2006 and 2012 using the National Cancer Database. A Cox proportional hazards model with inverse probability of treatment weighting (IPTW) using the propensity score was developed to assess the association between trimodality therapy and overall survival...
September 5, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28885335/rescue-patient-from-tracheal-obstruction-by-dislocated-bronchial-stent-during-tracheostomy-surgery-with-readily-available-tools-a-case-report
#4
Hung-Yu Chang, Kee-Ming Man, Kate Hsiurong Liao, Yi-Ying Chiang, Kuen-Bao Chen
RATIONALE: Airway stenting is a well-established method that relieves symptoms and maintains airway patency in patients with airway obstruction. Serious complications caused by airway stents such as stent dislocation and airway obstruction during surgery are life-threatening. PATIENT CONCERNS: An 80-year-old man was treated with bronchial stent for left bronchus obstruction caused by metastatic esophageal cancer. During tracheostomy surgery, he suffered from acute tracheal obstruction caused by dislocated bronchial stent...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28882975/gastric-tube-reconstruction-with-superdrainage-using-indocyanine-green-fluorescence-during-esophagectomy
#5
Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Kazuhiro Hanazaki
We report a case of gastric tube reconstruction with superdrainage using indocyanine green fluorescence during esophagectomy for esophageal cancer. A 53-year-old man with a history of early esophageal cancer treated with endoscopic mucosal dissection experienced esophageal cancer recurrence. There was no evidence of lymph node involvement or distant metastasis on computed tomography; therefore, we performed thoracoscopic esophagectomy. After thoracoscopic esophagectomy, we created a gastric tube. When pulling up the gastric tube through the post-mediastinum route, a root of the right gastroepiploic vein was injured...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28882179/medical-expenditure-for-esophageal-cancer-in-china-a-10-year-multicenter-retrospective-survey-2002-2011
#6
Lan-Wei Guo, Hui-Yao Huang, Ju-Fang Shi, Li-Hong Lv, Ya-Na Bai, A-Yan Mao, Xian-Zhen Liao, Guo-Xiang Liu, Jian-Song Ren, Xiao-Jie Sun, Xin-Yu Zhu, Jin-Yi Zhou, Ji-Yong Gong, Qi Zhou, Lin Zhu, Yu-Qin Liu, Bing-Bing Song, Ling-Bin Du, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Shou-Ling Wu, Rong Cao, Li Lan, Ying Ren, Kai Zhang, Jie He, Jian-Gong Zhang, Min Dai
BACKGROUND: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends. METHODS: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China...
September 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28881903/safety-and-efficacy-of-endoscopic-spray-cryotherapy-for-esophageal-cancer
#7
F C Tsai, S Ghorbani, B D Greenwald, S Jang, J A Dumot, M J McKinley, N J Shaheen, F Habr, H C Wolfsen, J A Abrams, C J Lightdale, N S Nishioka, M H Johnston, A Zfass, W J Coyle
Although surgery is traditionally the standard of care for esophageal cancer, esophagectomy carries significant morbidity. Alternative endoscopic therapies are needed for patients who are not candidates for conventional treatment. The objective of this study is to assess the safety, efficacy, and tolerability of spray cryotherapy of esophageal adenocarcinoma. This study includes patients with esophageal adenocarcinoma who had failed or were not candidates for conventional therapy enrolled retrospectively and prospectively in an open-label registry and patients in a retrospective cohort from 11 academic and community practices...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881891/induction-therapy-before-surgery-improves-survival-in-patients-with-clinical-t3n0-esophageal-cancer-a-nationwide-study-in-taiwan
#8
Y-K Chao, H-Y Ku, C-Y Chen, T-W Liu
The utility of induction therapy (IT) in patients with resectable esophageal cancer remains controversial, especially when clinical evidence of nodal metastases is lacking. We sought to compare the survival impact of IT versus upfront surgery (US) in patients with cT3N0 esophageal cancer. We searched the Taiwan Cancer Registry for patients with cT3N0 esophageal cancer who underwent US or IT between 2008 and 2013. Multivariate Cox regression analysis was used to analyze the potential benefits of IT in terms of overall survival (OS) and disease-free survival (DFS)...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881890/active-surveillance-in-clinically-complete-responders-after-neoadjuvant-chemoradiotherapy-for-esophageal-or-junctional-cancer
#9
B J Noordman, B P L Wijnhoven, S M Lagarde, K Biermann, A van der Gaast, M C W Spaander, R Valkema, J J B van Lanschot
Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is standard of care for locally advanced esophageal cancer in many countries. After nCRT up to one third of all patients have a pathologically complete response in the resection specimen, posing an ethical imperative to reconsider the necessity of standard surgery in all operable patients after nCRT. An active surveillance strategy following nCRT, in which patients are subjected to frequent clinical investigations after the completion of neoadjuvant therapy, has been evaluated in other types of cancer with promising results...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881884/clinical-outcomes-and-benefits-for-staging-of-surgical-lymph-node-mapping-after-esophagectomy
#10
S M Lagarde, A W Phillips, M Navidi, B Disep, S M Griffin
Dissection of lymph nodes (LN) immediately after esophagectomy is utilized by some surgeons to aid determination of LN stations involved in esophageal cancer. Some suggest that this increases LN yield and gives information regarding the pattern of lymphatic spread, others feel that this may compromise a circumferential resection margin (CRM) assessment. The aim of this study is to evaluate the effect of ex vivo dissection on the assessment of the CRM and the pattern of lymph node dissemination in patients with adenocarcinoma of the esophagus and gastroesophageal junction (GEJ) undergoing radical surgery after neoadjuvant chemotherapy and their prognostic impact...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881882/long-term-functional-outcomes-after-replacement-of-the-esophagus-with-gastric-colonic-or-jejunal-conduits-a-systematic-literature-review
#11
T Irino, A Tsekrekos, A Coppola, C M Scandavini, A Shetye, L Lundell, I Rouvelas
It is generally recognized that in patients with an intact stomach diagnosed with esophageal cancer, gastric tubulization and pull-up shall always be the preferred technique for reconstruction after an esophageal resection. However, in cases with extensive gastroesophageal junction (GEJ) cancer with aboral spread and after previous gastric surgery, alternative methods for reconstruction have to be pursued. Moreover, in benign cases as well as in those with early neoplastic lesions of the esophagus and the GEJ that are associated with long survival, it is basically unclear which conduit should be recommended...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28881608/anti-tumor-efficacy-of-theliatinib-in-esophageal-cancer-patient-derived-xenografts-models-with-epidermal-growth-factor-receptor-egfr-overexpression-and-gene-amplification
#12
Yongxin Ren, Jianming Zheng, Shiming Fan, Linfang Wang, Min Cheng, Dongxia Shi, Wei Zhang, Renxiang Tang, Ying Yu, Longxian Jiao, Jun Ni, Haibin Yang, Huaqing Cai, Fang Yin, Yunxin Chen, Feng Zhou, Weihan Zhang, Weiguo Qing, Weiguo Su
Targeted therapy is not yet approved for esophageal cancer (EC). In this study, we first evaluated EGFR gene and protein expression in 70 Chinese EC patient tumor samples collected during surgery. We then established 23 patient-derived EC xenograft (PDECX) models and assessed the efficacy of theliatinib, a potent and highly selective EGFR inhibitor currently in Phase I clinical study, in 9 PDECX models exhibiting various EGFR expression levels. Immunohistochemical analysis showed that 50 patient tumor samples (71...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874619/surgical-management-of-primary-and-recurrent-carcinoma-showing-thymous-like-elements-castle
#13
Federico Attene, Ilia Patrizia Pisano, Carlo Pala, Antonio Marrosu, Corrado Bozzo, Fabrizio Scognamillo
INTRODUCTION: Carcinoma showing thymous-like elements (CASTLE) is a rare tumor with only a few cases described in the scientific literature. The aim of the present review is to analyze the data available on the therapeutic options employed in CASTLE tumors and to outline the best surgical management to adopt. MATERIALS AND METHODS: English-language articles published from 1985 through November 2016, and related to CASTLE cases were retrieved using the Pubmed database and specific key-words...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28871799/costs-and-benefits-of-different-methods-of-esophagectomy-for-esophageal-cancer
#14
Alongkorn Yanasoot, Kamtorn Yolsuriyanwong, Sakchai Ruangsin, Supparerk Laohawiriyakamol, Somkiat Sunpaweravong
Background A minimally invasive approach to esophagectomy is being used increasingly, but concerns remain regarding the feasibility, safety, cost, and outcomes. We performed an analysis of the costs and benefits of minimally invasive, hybrid, and open esophagectomy approaches for esophageal cancer surgery. Methods The data of 83 consecutive patients who underwent a McKeown's esophagectomy at Prince of Songkla University Hospital between January 2008 and December 2014 were analyzed. Open esophagectomy was performed in 54 patients, minimally invasive esophagectomy in 13, and hybrid esophagectomy in 16...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28870932/clinical-significance-of-salvage-esophagectomy-for-patients-with-esophageal-cancer-and-factors-of-influencing-long-term-survival
#15
Makoto Sohda, Yuji Kumakura, Hideyuki Saito, Kengo Kuriyama, Tomonori Yoshida, Hiroaki Honjyo, Keigo Hara, Daigo Ozawa, Shigemasa Suzuki, Naritaka Tanaka, Makoto Sakai, Tatsuya Miyazaki, Minoru Fukuchi, Hiroyuki Kuwano
BACKGROUND/AIM: Definitive chemoradiotherapy (CRT) without planned surgery has been recently widely used as a therapeutic option for locally advanced esophageal cancer. Salvage esophagectomy can offer the chance of prolonged survival for patients who have locoregional failure after definitive CRT, but many clinicians oppose the use of surgery due to the associated excessive morbidity and mortality. The aim of this study was to identify patients who are good candidates for salvage surgery by investigating factors influencing long-term survival...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28870211/re-irradiation-for-oligo-recurrence-from-esophageal-cancer-with-radiotherapy-history-a-multi-institutional-study
#16
Keiichi Jingu, Yuzuru Niibe, Hideomi Yamashita, Kuniaki Katsui, Toshihiko Matsumoto, Tomohiro Nishina, Atsuro Terahara
BACKGROUND: Neoadjuvant chemoradiotherapy following surgery has recently become a standard therapy. The purpose of the present study was to determine the effectiveness and toxicity of re-irradiation for oligo-recurrence in lymph nodes from esophageal cancer treated by definitive radiotherapy or by surgery with additional radiotherapy. METHODS: We reviewed retrospectively 248 patients treated with (chemo)radiotherapy for oligo-recurrence in lymph nodes from esophageal cancer in five Japanese high-volume centers between 2000 and 2015...
September 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28867110/pet-computed-tomography-scanning-and-precision-medicine-esophageal-cancer
#17
REVIEW
Reema Goel, Rathan M Subramaniam, Jason W Wachsmann
Esophageal cancer commonly has a poor prognosis, which requires an accurate diagnosis and early treatment to improve outcome. Other modalities for staging, such as endoscopic ultrasound imaging and computed tomography (CT) scans, have a role in diagnosis and staging. However, PET with fluorine-18 fluoro-2-deoxy-d-glucose/CT (FDG PET/CT) scanning allows for improved detection of distant metastatic disease and can help to prevent unnecessary interventions that would increase morbidity. FDG PET/CT scanning is valuable in the neoadjuvant chemotherapy assessment and predicting survival outcomes subsequent to surgery...
October 2017: PET Clinics
https://www.readbyqxmd.com/read/28861809/negative-impact-of-skeletal-muscle-wasting-after-neoadjuvant-chemotherapy-followed-by-surgery-on-survival-for-patients-with-thoracic-esophageal-cancer
#18
Shuhei Mayanagi, Yasuhiro Tsubosa, Katsuhiro Omae, Masahiro Niihara, Tsuneyuki Uchida, Takahiro Tsushima, Tomoya Yokota, Hiroshi Sato, Tateaki Naito, Hirofumi Yasui
BACKGROUND: Skeletal muscle wasting during curative treatment is an important issue faced by esophageal cancer patients. However, it has not been clarified whether skeletal muscle change during neoadjuvant chemotherapy followed by surgery adversely affects prognosis. This study aimed to determine the relation between skeletal muscle change and survival for patients with advanced esophageal cancer who underwent neoadjuvant chemotherapy followed by surgery. METHODS: This study retrospectively analyzed 66 patients with thoracic esophageal cancer who had undergone neoadjuvant chemotherapy followed by esophagectomy...
August 31, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28861738/a-surgical-case-of-radiotherapy-induced-esophageal-perforation-accompanying-pyogenic-spondylodiscitis-a-case-report
#19
Shuntaro Yoshimura, Kazuhiko Mori, Koichiro Kawasaki, Asami Tanabe, Susumu Aikou, Koichi Yagi, Masato Nishida, Hiroharu Yamashita, Sachiyo Nomura, Masayoshi Fukushima, Hideomi Yamashita, Yasuhiro Yamauchi, Yasuyuki Seto
BACKGROUND: Stereotactic body radiotherapy has been a treatment choice for lung cancer, especially in medically inoperable patients. However, the acute and late toxicity to adjacent organs have been reported as an uncommon but severe adverse effect. CASE PRESENTATION: A 65-year-old male was presented with his back pain and pyrexia. He had been followed up for non-small-cell lung cancer, which was treated by the stereotactic body radiotherapy 4 years prior to the current visit...
August 31, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28859395/association-of-high-dose-postoperative-opioids-with-recurrence-risk-in-esophageal-squamous-cell-carcinoma-reinterpreting-eras-protocols-for-long-term-oncologic-surgery-outcomes
#20
T K Oh, J H Jeon, J M Lee, M S Kim, J H Kim, H Lim, S-E Kim, W Eom
Esophageal squamous cell carcinoma (ESCC) is associated with a poor prognosis and high postoperative recurrence rate. Although postoperative opioid use has been associated with cancer recurrence, its relevance in ESCC has not been determined. Therefore, this study investigated whether high-dose postoperative opioid use was associated with recurrence risk in patients with ESCC. For this retrospective analysis, the medical records of patients who were diagnosed with ESCC and who underwent surgery between January 2006 and December 2010 in the National Cancer Center, Korea were evaluated...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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