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https://www.readbyqxmd.com/read/28647071/volume-outcome-relationships-in-thoracic-surgery
#1
REVIEW
Benjamin D Kozower, George J Stukenborg
Most thoracic surgery studies indicate that hospital and surgeon procedure volume are inversely associated with mortality. However, controversy exists regarding the strength and validity of this volume-outcome association. Because thresholds of procedure volume are used to recommend the regionalization of care, investigation of the volume-outcome relationship is imperative. This article examines the methodology used in the volume-outcome relationship literature and highlights important areas of concern. Careful examination of the literature demonstrates that lung and esophageal cancer resection volume is not strongly associated with mortality and should not be used as a proxy measure for quality...
August 2017: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/28647069/oncologic-quality-indicators-in-thoracic-surgery
#2
REVIEW
Jessica Hudson, Tara Semenkovich, Varun Puri
This article outlines a structure for assessing thoracic surgical quality and provides an overview of evidence-based quality metrics for surgical care in both lung cancer and esophageal cancer, with a focus on process and outcome measures in the preoperative, intraoperative, and postoperative setting.
August 2017: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/28636829/analysis-of-minimally-invasive-esophagectomy-at-a-single-veterans-affairs-medical-center
#3
Matthew D Skancke, Robert A Grossman, Gustavo Marino, Fredrick J Brody, Gregory D Trachiotis
BACKGROUND: To date, there are no published studies focusing on the benefits of minimally invasive esophagectomy (MIE) versus open esophagectomy at a Veterans Affairs Medical Center (VAMC). Our primary outcome was the incidence of esophageal malignancy in the veteran population and the postoperative morbidity following traditional and MIE for malignancy. DESIGN: Retrospective analysis of the incidence of esophageal malignancy at a Veteran Integrated Service Network (VISN) 5 VAMC reported to the VAMC Esophageal Tumor Registry between 2003 and 2016 and outcomes of the veterans who received esophagectomy for malignancy...
June 21, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28628507/patient-reported-outcomes-following-neoadjuvant-chemotherapy-or-chemoradiotherapy-treatment-for-esophageal-cancer-a-scoping-review-protocol
#4
Camilla Trenerry, Micah D J Peters, Nadia Corsini, Raechel A Damarell, Carlene Wilson, Ingrid Flight
The objective of this scoping review is to identify, describe and compare studies investigating patient-reported outcomes (PROs) in esophageal cancer patients following neoadjuvant (preoperative) chemotherapy (CT) and surgery or neoadjuvant chemoradiotherapy (CRT) and surgery.After preliminary searching of the literature and consultation with experts in the fields of esophageal cancer surgery, behavioral science, information systems and scoping review methodology, the following research objectives were defined as follows...
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28621676/psychiatric-morbidity-and-its-impact-on-surgical-outcomes-for-esophageal-and-gastric-cancer-patients-a-nationwide-cohort-study
#5
Huan Song, Jianwei Zhu, Donghao Lu, Fang Fang, Weimin Ye, Lars Lundell, Jan Johansson, Mats Lindblad, Magnus Nilsson
BACKGROUND: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive. RESULTS: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1...
June 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28616599/current-status-and-future-perspectives-of-laparoscopic-radical-surgery-for-advanced-gastric-cancer
#6
REVIEW
Takahiro Kinoshita, Akio Kaito
Laparoscopic radical gastrectomy with lymph node dissection has widely penetrated to East Asian countries, where incidence of gastric cancer occurrence is higher than the rest of the world. Laparoscopic distal gastrectomy for cStageI disease is regarded as one of the option in daily practice in the latest Japanese guidelines; however its applicability to more advanced disease (Stage II/III) is still under debate. Actually, operative techniques of laparoscopic D2 dissection is being matured, but still, necessity of total omentectomy, splenic hilar dissection, management of bulky nodes or large primary tumor, high-level anastomosis in esophageal invasion cases, and extensive peritoneal lavage can be raised as technical limitations...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28616399/management-of-strictures-after-endoscopic-submucosal-dissection-for-superficial-esophageal-cancer
#7
REVIEW
Koichiro Kawaguchi, Hiroki Kurumi, Yohei Takeda, Kazuo Yashima, Hajime Isomoto
Endoscopic resection of early esophageal cancer has a high therapeutic effect while being minimally invasive. Especially, the establishment of the endoscopic submucosal dissection (ESD) procedure has made it possible to resect large lesions in an en-bloc manner. As a result, accurate pathology evaluation became possible, and the risk of local recurrence was extremely low. On the other hand, esophageal strictures after endoscopic treatment of an extensive circumferential lesion are a potential problem. Previously, for the prevention and treatment of esophageal strictures, patients had to undergo painful endoscopic balloon dilation (EBD) many times...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28616284/intrapleural-perfusion-thermo-chemotherapy-for-pleural-effusion-caused-by-lung-carcinoma-under-vats
#8
Runlei Hu, Hong Jiang, Hu Li, Dongshan Wei, Guoqing Wang, Shenglin Ma
BACKGROUND: The aim of this study was to assess the effectiveness of intrapleural perfusion thermo-chemotherapy (IPTC) under video-assisted thoracoscopic surgery (VATS) for malignant pleural effusion (MPE) caused by lung carcinoma. METHODS: In this retrospective study, fifty-four patients with moderate or large amounts of ipsilateral MPE secondary to non-small cell lung cancer (NSCLC) underwent pleural biopsy and IPTC under VATS. IPTC was performed by perfusing the pleural cavity with 43...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28615010/internet-based-perioperative-exercise-program-in-patients-with-barrett-s-carcinoma-scheduled-for-esophagectomy-ipep-study-a-prospective-randomized-controlled-trial
#9
Daniel Pfirrmann, Suzan Tug, Oana Brosteanu, Matthias Mehdorn, Martin Busse, Peter P Grimminger, Florian Lordick, Torben Glatz, Jens Hoeppner, Hauke Lang, Perikles Simon, Ines Gockel
BACKGROUND: Patients undergoing surgery for esophageal cancer have a high risk for postoperative deterioration of lung function and pulmonary complications. This is partly due to one-lung ventilation during thoracotomy. This often accounts for prolonged stay on intensive care units, delayed postoperative reconvalescence and reduced quality of life. Socioeconomic disadvantages can result from these problems. Physical preconditioning has become a crucial leverage to optimize fitness and lung function in patients scheduled for esophagectomy, in particular during the time period of neoadjuvant therapy...
June 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28608916/value-and-application-of-trimodality-therapy-or-definitive-concurrent-chemoradiotherapy-in-thoracic-esophageal-squamous-cell-carcinoma
#10
Wei-Cheng Lin, Yi-Fang Ding, Han-Lin Hsu, Jer-Hwa Chang, Kevin Sheng-Po Yuan, Alexander T H Wu, Jyh-Ming Chow, Chia-Lun Chang, Shee-Uan Chen, Szu-Yuan Wu
BACKGROUND: Few large, prospective, randomized studies have investigated the value and optimal application of neoadjuvant chemoradiotherapy followed by surgery (trimodality therapy) or definitive concurrent chemoradiotherapy (CCRT) for patients with thoracic esophageal squamous cell carcinoma (TESCC). METHODS: The authors analyzed data from patients with TESCC in the Taiwan Cancer Registry database. To compare their outcomes, patients with TESCC were enrolled and categorized into the following groups according to treatment modality: group 1, those who underwent surgery alone; group 2, those who received trimodality therapy; and group 3, those who received definitive CCRT...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28608015/prognostic-impact-of-change-in-the-fibrinogen-and-albumin-score-during-preoperative-treatment-in-esophageal-cancer-patients
#11
Satoru Matsuda, Hiroya Takeuchi, Hirofumi Kawakubo, Kazumasa Fukuda, Rieko Nakamura, Koichi Suda, Norihito Wada, Yuko Kitagawa
BACKGROUND: For resectable advanced esophageal cancer, a transthoracic esophagectomy following preoperative treatment is recognized as one of the standard treatments. Therefore, predictive markers which can be identified before surgery need to be established to identify patients with a poor prognosis. METHODS: We retrospectively reviewed 102 consecutive patients who underwent curative transthoracic esophagectomy following preoperative treatment in our institution between 2004 and 2013...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28608012/the-advent-of-ultra-high-volume-thoracic-surgical-centers-in-shanghai
#12
Alan D L Sihoe, Baohui Han, Timothy Y Yang, Changqing Pan, Gening Jiang, Vincent W T Fang
BACKGROUND: A core principle in surgery is that high surgical volumes are conducive toward better outcomes. Ultra-high volume centers (UHVCs) have now emerged in thoracic surgery in China that now perform a volume of thoracic operations far greater than even traditional international centers of excellence. METHODS: In 2016, two hospitals in Shanghai performed over 10,000 major pulmonary, esophageal and mediastinal resections each. A qualitative analysis of the lessons learned in achieving such large operation volumes was undertaken...
June 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28607505/predictive-genetic-markers-in-neoadjuvant-chemoradiotherapy-for-locally-advanced-esophageal-cancer-a-long-way-to-go-review-of-the-literature
#13
REVIEW
M Gusella, E Pezzolo, Y Modena, C Barile, D Menon, G Crepaldi, F La Russa, A P Fraccon, F Pasini
The role of genetic molecular markers in neoadjuvant treatment for locally advanced esophageal cancer has been reviewed, focusing strictly on concurrent chemoradiation protocols followed by surgery. Eleven studies evaluated the role of mRNA expression profile; the end point was overall survival (OS) in two studies and different definitions of histological response in nine. Genes reported as significant were involved in cell cycle control (30), apoptosis (7), structural molecules (9), cell metabolism (6) and DNA repair (1)...
June 13, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28602545/what-is-the-impact-of-neoadjuvant-chemoradiation-on-outcomes-in-gastro-intestinal-cancer
#14
C Mariette, A Brouquet, D Tzanis, A Laurenzi, A de la Rochefordière, P Mariani, G Piessen, A Sa Cunha, C Penna
Multimodal therapeutic strategies combining chemotherapy, radiation therapy and surgery have been shown to be feasible and to have a positive impact on outcomes by decreasing the risk of locoregional recurrence and often by increasing overall survival. The advantages of neoadjuvant chemo(radio)therapy include optimal tumor control combined with better tolerance and compliance to treatment while also increasing the number of candidates for surgery. Whereas indications for neoadjuvant therapy are increasing, its impact on surgical treatment and postoperative outcomes are not well-known...
June 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28602412/definitive-chemoradiation-therapy-for-esophageal-cancer-in-the-elderly-clinical-outcomes-for-patients-exceeding-80%C3%A2-years-old
#15
Cai Xu, Mian Xi, Amy Moreno, Yutaka Shiraishi, Brian P Hobbs, Meilin Huang, Ritsuko Komaki, Steven H Lin
PURPOSE: The optimal treatment approach for patients ≥80 years ("elderly") with esophageal cancer is not well established. We assessed the clinical outcomes in elderly patients treated with definitive chemoradiation therapy (CCRT) at our institution. METHODS AND MATERIALS: 56 consecutive patients ≥80 years with esophageal cancer treated with conventional CCRT between 2001 and 2016 were propensity score matched 1:2 to generate 2 younger patient cohorts treated with CCRT without surgery: "intermediate" (65-79 years, n=112) and "younger" (<65 years, n=112)...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28601935/a-novel-systemic-immune-inflammation-index-predicts-survival-and-quality-of-life-of-patients-after-curative-resection-for-esophageal-squamous-cell-carcinoma
#16
Lu Wang, Cong Wang, Jiangfeng Wang, Xiaochen Huang, Yufeng Cheng
PURPOSE: A novel systemic immune-inflammation index (SII) based on platelet (P), neutrophil (N), and lymphocyte (L) counts has been reported to be associated with clinical outcomes in several solid tumors. We aimed to investigate its prognostic value in esophageal squamous cell carcinoma (ESCC) and the potential relationship with quality of life (QOL). METHODS: A total of 280 ESCC patients who underwent esophagectomy were enrolled. SII (SII = P × N/L) was calculated on the basis of data obtained within 1 week before surgery...
June 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28591092/the-role-of-radiation-therapy-in-upper-gastrointestinal-cancers
#17
David H Ilson
Upper gastrointestinal cancers are common and account for a high proportion of cases of cancer-related morbidity and mortality. Combined-modality therapy with surgery, chemotherapy, and radiation therapy is standard treatment for esophageal and gastroesophageal junction cancers. For gastric cancer, the need to include radiation therapy appears to depend on the quality of the surgery performed. Radiation therapy plays an uncertain role in the surgical management of pancreatic cancer, and the results of ongoing clinical trials are awaited...
May 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28588716/low-expression-of-mir-1469-predicts-disease-progression-and-unfavorable-post-surgical-clinical-outcomes-in-patients-with-esophageal-squamous-cell-cancer
#18
Jin Liu, Chuifang Wang, Xiangyan Liu, Yu Wang, Haibo Liu, Guohua Ren, Liangming Zhu, Zhigang Sun, Zhitao Chen
Recent studies have demonstrated that deregulated microRNA (miRNA/miR) expression has a profound impact on biological and pathological processes; abnormal miR-1469 expression was detected in several human malignancies. In the present study, the clinicopathological and prognostic significance of miR-1469 was assessed in 129 patients with esophageal squamous cell cancer (ESCC) who successfully underwent esophagectomy and esophagogastrostomy. Low miR-1469 expression was identified to be significantly associated with tumor invasion depth (P=0...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28587972/salvage-photodynamic-therapy-accompanied-by-extended-lymphadenectomy-for-advanced-esophageal-carcinoma-a-case-report
#19
Takahiro Nishida, Shinsuke Takeno, Koji Nakashima, Masato Kariya, Haruhiko Inatsu, Kazuo Kitamura, Atsushi Nanashima
INTRODUCTION: Salvage surgery for locoregional failures after definitive chemoradiotherapy (dCRT) for esophageal cancer is widely practiced, but treatment options complementing it are also needed due to the high morbidity and mortality and low rate of curative resection. PRESENTATION OF CASE: A 58-year-old man with a surgical history of right upper lobectomy for lung cancer was diagnosed as having esophageal squamous cell carcinoma. Computed tomography revealed swelling of the lesser curvature lymph node, and it had invaded the stomach, the body and tail of the pancreas and the left gastric artery, splenic artery and celiac artery...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28585161/is-18-f-fdg-pet-useful-for-predicting-r0-resection-after-induction-therapy-for-initially-unresectable-locally-advanced-esophageal-carcinoma
#20
Keijiro Sugimura, Hiroshi Miyata, Masahiko Yano, Yoshitomo Yanagimoto, Moon Jeong Ho, Shogo Kobayashi, Hidenori Takahashi, Takeshi Omori, Masayuki Ohue, Masato Sakon
OBJECTIVE: Induction therapy followed by surgery is a promising strategy for esophageal cancer patients with invasion of the trachea/bronchus or aorta. However, no diagnostic criteria have been established to diagnose whether R0 resection can be performed. We investigated whether (18)F-2-deoxy-D-glucose positron emission tomography ((18)F-FDG-PET) and other modalities are useful for predicting R0 resection. METHODS: Fifty-seven patients with esophageal cancer invading the trachea/bronchus or aorta who underwent induction therapy followed by surgery were enrolled...
June 5, 2017: General Thoracic and Cardiovascular Surgery
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