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Esophageal cancer surgery

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https://www.readbyqxmd.com/read/27931038/heterogeneity-of-glucose-metabolism-in-esophageal-cancer-measured-by-fractal-analysis-of-fluorodeoxyglucose-positron-emission-tomography-image-correlation-between-metabolic-heterogeneity-and-survival
#1
Toru Tochigi, Kiyohiko Shuto, Tsuguaki Kono, Gaku Ohira, Takayuki Tohma, Hisashi Gunji, Koichi Hayano, Kazuo Narushima, Takeshi Fujishiro, Toshiharu Hanaoka, Yasunori Akutsu, Shinichi Okazumi, Hisahiro Matsubara
BACKGROUND: Intratumoral heterogeneity is a well-recognized characteristic feature of cancer. The purpose of this study is to assess the heterogeneity of the intratumoral glucose metabolism using fractal analysis, and evaluate its prognostic value in patients with esophageal squamous cell carcinoma (ESCC). METHODS: 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) studies of 79 patients who received curative surgery were evaluated. FDG-PET images were analyzed using fractal analysis software, where differential box-counting method was employed to calculate the fractal dimension (FD) of the tumor lesion...
December 9, 2016: Digestive Surgery
https://www.readbyqxmd.com/read/27929699/elucidating-trainee-effect-on-outcomes-for-general-gynecologic-and-urologic-oncology-procedures
#2
Megan Sippey, Konstantinos Spaniolas, Kevin R Kasten
BACKGROUND AND OBJECTIVES: Surgical complications delay adjuvant therapy in oncology patients. Current literature remains unclear regarding resident effect on postoperative outcomes, with inappropriate coverage possibly endangering patients in spite of attending oversight. We assessed resident postgraduate year (PGY) effect on 30-day overall morbidity in cancer patients undergoing major intra-abdominal and non-abdominal surgery. METHODS: Patients undergoing non-emergent major intra- and extra-abdominal operations from 2005-2012 were queried using the American College of Surgeons' National Surgical Quality Improvement Program...
December 8, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27928446/gastrostomy-with-peritoneal-collar-versus-percutaneous-endoscopic-gastrostomy
#3
Tudor C, Branescu C, Savlovschi C, El-Khatib A, Pantu H, Nica A, Dascalu Am, Masoumeh B, Tudor As, Oprescu Sm, Serban D
Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted for a surgical solution for feeding. The indications, preoperative preparation, surgical techniques, and postoperative outcomes were analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27921193/an-isoperistaltic-jejunum-later-cut-overlap-method-for-esophagojejunostomy-anastomosis-after-totally-laparoscopic-total-gastrectomy-a-safe-and-feasible-technique
#4
Chang-Ming Huang, Ze-Ning Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu
BACKGROUND: Intracorporeal anastomosis after totally laparoscopic total gastrectomy (TLTG) has been increasingly applied. (1-7) We assessed the intracorporeal isoperistaltic jejunum-later-cut overlap method (IJOM) for esophagojejunostomy anastomosis (EA). METHODS: From January to June 2014, a total of 19 patients with resectable gastric cancer (cT1-T4aNOM0) underwent TLTG. IJOM was performed by creating side-to-side stapled anastomosis through enterotomies proximal to the left esophageal resection margin and on the antimesenteric jejunal border, 30 cm distal to the Trietz ligament...
December 5, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27920002/decreased-skeletal-muscle-mass-after-neoadjuvant-therapy-correlates-with-poor-prognosis-in-patients-with-esophageal-cancer
#5
Jiajia Liu, Satoru Motoyama, Yusuke Sato, Akiyuki Wakita, Yuta Kawakita, Hajime Saito, Yoshihiro Minamiya
BACKGROUND: Loss of skeletal muscle is predictive of a poor prognosis in patients with various malignant lesions. Our aim was to determine whether changes in skeletal muscle after neo-adjuvant therapy (NAT) predict prognosis in patients with esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy. PATIENTS AND METHODS: The cross-sectional areas of the psoas muscles were measured on computed tomographic images collected at the initial visit, preoperatively and postoperatively in 84 patients...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27916166/recurrence-after-surgery-in-esophago-gastric-junction-adenocarcinoma-current-management-and-future-perspectives
#6
Alessandro Neri, Daniele Marrelli, Costantino Voglino, Giulio Di Mare, Francesco Ferrara, Mario Marini, Franco Roviello
Recurrent esophago-gastric junction adenocarcinoma is not a rare event and its correct management is still debated. Many approaches for the treatment of these patients exist, but only few studies compare the different techniques. Most of the studies are retrospectives series and describe the experiences of single institutions in the treatment of recurrent esophageal and esophago-gastric junction cancers. Nowadays surgery is still the main and only curative treatment. Other alternative palliative therapies could be endoscopic stent placement and balloon dilation, photodynamic therapy, thermal tumor ablation (laser photoablation and Argon plasma coagulation), radiation therapy and brachytherapy, and chemotherapy...
December 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27910227/preoperative-computed-tomography-diagnosis-of-non-recurrent-laryngeal-nerve-in-patients-with-esophageal-carcinoma
#7
Zhong-Xi Niu, Hang Zhang, Long-Qi Chen, Hui Shi, Jun Peng, Li-Wei Su, Wei Li, Bo Xiao, Shu He, Hong-Xu Yue
BACKGROUND: The non-recurrent laryngeal nerve (NRLN) is a rare but potentially serious anomaly that is commonly associated with the aberrant right subclavian artery (ARSA). It is easy to damage during surgical resection of esophageal cancer, leading to severe complications. METHODS: Preoperative enhanced thoracic computed tomography (CT) scans of 2697 patients with esophageal carcinoma treated in our hospital between January 2010 and December 2013 were examined...
December 2, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27909875/one-anastomosis-gastric-bypass-why-biliary-reflux-remains-controversial
#8
Matthieu Bruzzi, Jean-Marc Chevallier, Sébastien Czernichow
One-anastomosis gastric bypass is an alternative to the "gold-standard" Roux-en-Y gastric bypass. This technique appears to be safe and efficient, but controversy remains regarding the long-term theoretical risk of subsequent biliary reflux and its possible complications, such as cancer. The aim of the present narrative review was to summarize some of the current thoughts on biliary reflux. Research has established that exposure to chronic bile reflux in humans and rats (outside the "bariatric surgery" box) induce esophageal intestinal metaplasia and esophageal adenocarcinoma...
December 1, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27907921/feasibility-of-preoperative-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil-versus-adriamycin-cisplatin-and-5-fluorouracil-for-resectable-advanced-esophageal-cancer
#9
Osamu Shiraishi, Makoto Yamasaki, Tomoki Makino, Masaaki Motoori, Hiroshi Miyata, Masayuki Shinkai, Yutaka Kimura, Motohiro Hirao, Kazumasa Fujitani, Shigeyuki Tamura, Kenji Kobayashi, Masahiko Yano, Yuichiro Doki, Takushi Yasuda
BACKGROUND: Neoadjuvant chemotherapy for resectable advanced esophageal squamous cell carcinoma (ESCC) requires reassessment. We have conducted a trial aiming at the comparison between DCF and ACF concerning perioperative adverse events. METHODS: Patients were randomly assigned to receive either DCF [docetaxel 70 mg/m2, cisplatin 70 mg/m2 on day 1, and 5-fluorouracil (5-FU) 700 mg/m2 for 5 days] every 3 weeks or ACF (adriamycin 35 mg/m2, cisplatin 70 mg/m2 on day 1, and 5-FU 700 mg/m2 for 7 days) every 4 weeks...
December 2, 2016: Oncology
https://www.readbyqxmd.com/read/27904842/the-challenges-of-cardiothoracic-surgery-practice-in-nigeria-a-12-years-institutional-experience
#10
Bode Falase, Michael Sanusi, Adeola Animasahun, Ogadinma Mgbajah, Adetinuwe Majekodunmi, Onyekwelu Nzewi, Jonathan Nwiloh, David Oke
BACKGROUND: Although the specialty of cardiothoracic surgery has been practiced in Nigeria for many years, open heart surgery (OHS) has only in the last decade become relatively more frequent, mainly through visiting foreign cardiac surgical teams. At this early phase of development it is faced with multiple challenges, especially financing and local skilled manpower for which solutions have to be identified in order to ensure sustainability and future growth. This study is aimed at highlighting these obstacles to growth of cardiothoracic surgery based on our own institutional experience at Lagos State University Teaching Hospital (LASUTH) and the current status of OHS activity in other cardiothoracic centers in Nigeria...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27904579/comparison-of-pyloromyotomy-pyloric-buginage-and-intact-pylorus-on-gastric-drainage-in-gastric-pull-up-surgery-after-esophagectomy
#11
Gholamreza Mohajeri, Seyed Abbas Tabatabaei, Seyed Mozafar Hashemi, Hamidreza Hemmati
BACKGROUND: There are controversies regarding the usefulness of the pyloric drainage methods after esophagectomy as well as differences among various pyloric drainage techniques. Therefore, we compared the outcome of pyloromyotomy, pylorus buginage, and no intervention methods on gastric emptying among patients undergone esophagectomy. MATERIALS AND METHODS: In this randomized clinical trial, patients with diagnosed esophageal cancer or any other benign lesions candidate for esophagectomy were selected...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27900538/seom-clinical-guideline-for-the-diagnosis-and-treatment-of-esophageal-cancer-2016
#12
M Martin-Richard, R Díaz Beveridge, V Arrazubi, M Alsina, M Galan Guzmán, A B Custodio, C Gómez, F L Muñoz, R Pazo, F Rivera
Esophageal cancer (EC) is an aggressive tumor that represents the 6th most common cause of cancer death worldwide. The estimated incidence in Spain is 2090 cases/year. Two main pathological subtypes exist, squamous cell carcinoma and adenocarcinoma. The main differences between them are localization and underlying factors which are the principal cause of the recent incidence changes observed in west countries. Staging techniques and treatment options which combine surgery, chemotherapy and radiotherapy, reflected the high complexity of the EC management...
December 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27890801/eus-guided-paclitaxel-injection-as-an-adjunctive-therapy-to-systemic-chemotherapy-and-concurrent-external-beam-radiation-before-surgery-for-localized-or-locoregional-esophageal-cancer-a-multicenter-prospective-randomized-trial
#13
John M DeWitt, S Krishna Murthy, Ramesh Ardhanari, G Aaron DuVall, Grzegorz Wallner, Paul Litka, Claire Daugherty, Kirk Fowers
BACKGROUND AND AIMS: OncoGel is paclitaxel (PTX) formulated in a thermosensitive, biodegradable copolymer for focused cytotoxicity and radiosensitization. A phase IIa study suggested EUS-guided PTX injection into esophageal tumors subsequently receiving radiation therapy (RT) was safe. METHODS: In an international multicenter, prospective randomized phase IIb study, patients with local or locoregional adenocarcinoma or squamous cell carcinoma (SCCA) of the esophagus/GE junction and eligible for neoadjuvant chemoradiotherapy (CRT) before surgery were randomized to standard of care (SOC) plus EUS-guided PTX injection or SOC alone...
November 24, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27888508/outcomes-following-laryngectomy-refusal-after-insufficient-response-to-induction-chemotherapy
#14
Philippe Gorphe, Margarida Matias, Pierre Blanchard, Caroline Even, Charles Ferte, Yungan Tao, Stéphane Temam, François Bidault, François Janot
OBJECTIVE: To review patients who refused a total laryngectomy and were treated with radiotherapy (RT) after insufficient response to induction chemotherapy in a larynx preservation protocol for advanced-stage cancer of the larynx and to compare their outcomes with good responders. STUDY DESIGN: Retrospective cohort study. METHODS: Eighty-six patients treated with induction chemotherapy followed by RT were included in the analysis: 75 good responders and 11 insufficient responders who refused surgery...
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27879527/support-vector-machines-model-of-computed-tomography-for-assessing-lymph-node-metastasis-in-esophageal-cancer-with-neoadjuvant-chemotherapy
#15
Zhi-Long Wang, Zhi-Guo Zhou, Ying Chen, Xiao-Ting Li, Ying-Shi Sun
OBJECTIVE: The aim of this study was to diagnose lymph node metastasis of esophageal cancer by support vector machines model based on computed tomography. MATERIALS AND METHODS: A total of 131 esophageal cancer patients with preoperative chemotherapy and radical surgery were included. Various indicators (tumor thickness, tumor length, tumor CT value, total number of lymph nodes, and long axis and short axis sizes of largest lymph node) on CT images before and after neoadjuvant chemotherapy were recorded...
November 23, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27878893/survival-outcomes-of-consolidation-chemoradiotherapy-in-esophageal-cancer-patients-who-achieve-clinical-complete-response-but-refuse-surgery-after-neoadjuvant-chemoradiotherapy
#16
Hsin-Yueh Fang, Yin-Kai Chao, Hsien-Kun Chang, Chen-Kan Tseng, Yun-Hen Liu
Some esophageal cancer patients may be reluctant to accept the scheduled resection after neoadjuvant chemoradiotherapy (nCRT) because of its potential negative impact on quality of life as a result of high morbidity. This study was performed to investigate the survival outcomes of these patients. Between 2000 and 2012, we identified 190 patients with resectable esophageal squamous cell carcinoma (ESCC) who did not proceed to surgery following nCRT. Subjects who had a clinical complete response (cCR) and were medically fit for surgery were deemed eligible...
November 23, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27869098/radiation-dose-escalation-in-esophageal-cancer-revisited-a-contemporary-analysis-of-the-national-cancer-data-base-2004-to-2012
#17
Jeffrey V Brower, Shuai Chen, Michael F Bassetti, Menggang Yu, Paul M Harari, Mark A Ritter, Andrew M Baschnagel
PURPOSE: To evaluate the effect of radiation dose escalation on overall survival (OS) for patients with nonmetastatic esophageal cancer treated with concurrent radiation and chemotherapy. METHODS AND MATERIALS: Patients diagnosed with stage I to III esophageal cancer treated from 2004 to 2012 were identified from the National Cancer Data Base. Patients who received concurrent radiation and chemotherapy with radiation doses of ≥50 Gy and did not undergo surgery were included...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27868290/outcomes-of-definitive-chemoradiation-in-patients-with-esophageal-cancer
#18
REVIEW
Sameh Mikhail, Lai Wei, Mohamed E Salem, Tanios Bekaii-Saab
The incidence of esophageal cancer has risen dramatically in the Western world. Although surgical resection of esophageal tumors is considered the cornerstone of curative approaches in localized esophageal cancer, approximately 40% of patients who undergo chemoradiation followed by surgery will experience a recurrence. Additionally, surgical resection is not a viable option for many patients with locally advanced unresectable disease, poor general condition or whose condition deteriorated following chemoradiation...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27868287/development-of-a-nomogram-for-the-prediction-of-pathological-complete-response-after-neoadjuvant-chemoradiotherapy-in-patients-with-esophageal-squamous-cell-carcinoma
#19
Yin-Kai Chao, Hsien-Kun Chang, Chen-Kan Tseng, Yun-Hen Liu, Yu-Wen Wen
Nomograms incorporating multiple prognostic factors are useful for individualized estimation of survival in cancer patients. However, nomograms for the prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal cancer are scarce. Here, we describe the development of a nomogram for predicting pCR after nCRT in patients with esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed the records of 392 ESCC patients who underwent nCRT followed by esophagectomy...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27868285/review-of-chemotherapeutic-approaches-for-operable-and-inoperable-esophageal-squamous-cell-carcinoma
#20
REVIEW
Y Baba, H Saeki, Y Nakashima, E Oki, H Shigaki, N Yoshida, M Watanabe, Y Maehara, H Baba
The predominant histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Since these two histological types present as different diseases in terms of their epidemiology, pathologenesis, and tumor biology, separate therapeutic approaches should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma (ESCC), their high rates of tumor recurrence have prompted investigation of multimodality therapies that combine surgery with chemotherapy, radiotherapy, and chemoradiotherapy...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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