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Esophageal cancer surgery

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https://www.readbyqxmd.com/read/28735527/fibroblast-activating-protein-%C3%AE-expression-in-squamous-cell-carcinoma-of-the-esophagus-in-primary-and-irradiated-tumors-the-use-of-archival-ffpe-material-for-molecular-techniques
#1
Renata Tabola, Magdalena Zaremba-Czogalla, Dagmara Baczynska, Roberto Cirocchi, Kamila Stach, Krzysztof Grabowski, Katarzyna Augoff
There are numerous reports suggesting that fibroblast activating protein-α (FAP-α) plays an important role in invasion of various tumor types. We studied the expression pattern of FAP-α in esophageal squamous cell carcinoma (ESCC) patients who had not been treated primarily and those who had received neoadjuvant radiochemotherapy. Our goal was to establish whether readily available tissue specimens fixed in formalin and stored in paraffin blocks for years might still be a source of FAP-α RNA for PCR analysis...
June 20, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28734410/clinical-trials-in-thoracic-surgery-a-report-from-ginsberg-day-2017-and-early-risers-at-sts-2017
#2
Linda W Martin, Dennis A Wigle
No unified source lists clinical trials relevant to general thoracic surgery. This description summarizes the current offerings across the National Cancer Institute Cooperative Group-sponsored clinical trials, and includes trials involving surgery for lung cancer and esophageal cancer, and in some instances, perioperative management of patients undergoing thoracic surgery.
August 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28728714/the-impact-of-minimally-invasive-esophageal-surgery
#3
REVIEW
Thomas Fabian, John A Federico
Many esophageal patients with cancer were undertreated for their malignancy, which played a role in the poor long-term survival rate. Surgeons have been eager to see real change in short-term and long-term outcomes. Dramatic and profound advances continue toward improving surgical outcomes, techniques, and expanding the reach of esophagectomy, especially the use of minimally invasive techniques. This article discusses the surgical innovations that have occurred in the last decade and their impact on patients with esophageal cancer...
August 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28727635/salvage-endoscopic-argon-plasma-coagulation-after-chemoradiotherapy-for-inoperable-esophageal-cancer
#4
Takeshi Matsutani, Tsutomu Nomura, Nobutoshi Hagiwara, Akihisa Matsuda, Eiji Uchida
PURPOSE: The purpose of this study is to evaluate the effectiveness of salvage endoscopic argon plasma coagulation (APC) therapy for local failure occurring after definitive chemoradiotherapy (CRT) in patients with inoperable esophageal cancer. PATIENTS AND METHODS: A total of 47 patients with esophageal squamous cell carcinoma received CRT from January 2009 through November 2011 in our hospital. Thirty-five of these patients were excluded because of long-term disease-free status or because they received salvage surgery, systemic chemotherapy, or best supportive care...
July 19, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28726497/prognosis-prediction-for-postoperative-esophageal-cancer-patients-using-onodera-s-prognostic-nutritional-index
#5
Hideo Matsumoto, Yuko Okamoto, Akimasa Kawai, Daisuke Ueno, Hisako Kubota, Haruaki Murakami, Masaharu Higashida, Toshihiro Hirai
PURPOSE: Preoperative nutritional status may impact surgical outcome and prognosis. We evaluated the predictive value of Onodera's prognostic nutritional index (O's-PNI) of surgical outcome following esophagectomy in esophageal cancer patients. PATIENTS AND METHODS: In total, 144 patients undergoing esophagectomy for esophageal cancer from April 2010 to May 2015 were evaluated, retrospectively. Eighty-four patients were enrolled in this study. O's-PNIs were calculated before surgery, discharge, and 1, 2, and 6 mo after discharge...
July 20, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28723668/a-rare-case-of-esophageal-metastasis-from-pancreatic-ductal-adenocarcinoma-a-case-report-and-literature-review
#6
Lauren M Rosati, Megan N Kummerlowe, Justin Poling, Amy Hacker-Prietz, Amol K Narang, Eun J Shin, Dung T Le, Elliot K Fishman, Ralph H Hruban, Stephen C Yang, Matthew J Weiss, Joseph M Herman
PURPOSE: We report a very unique case of an esophageal metastasis from a pancreatic ductal adenocarcinoma (PDAC) primary. METHODS: After obtaining consent from the patient, all relevant records of the case were obtained and retrospectively reviewed. RESULTS: At presentation, the patient was diagnosed with synchronous pancreatic and esophageal cancer. He received six months of neoadjuvant therapy including FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and stereotactic body radiation therapy (SBRT) to the pancreatic tumor followed by a combined pancreaticoduodenectomy and Ivor Lewis esophagectomy...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721567/modified-double-layer-anastomosis-for-minimally-invasive-esophagectomy-an-effective-way-to-prevent-leakage-and-stricture
#7
Yong Yuan, Xiao-Xi Zeng, Yong-Fan Zhao, Long-Qi Chen
BACKGROUND: Anastomotic leakage and stricture contribute to a large number of mortality and morbidity after esophagectomy. The aim of this work is to evaluate the outcome of modified double-layer hand-sewn esophagogastric anastomosis during minimally invasive esophagectomy for esophageal cancer. METHODS: The clinicopathological data of 176 consecutive esophageal cancer patients who underwent cervical esophagogastric anastomosis using modified double-layer hand-sewn technique after radical esophagectomy were retrospectively reviewed...
July 18, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28716377/comparison-of-the-7th-and-proposed-8th-editions-of-the-ajcc-uicc-tnm-staging-system-for-esophageal-squamous-cell-carcinoma-underwent-radical-surgery
#8
D Zhang, Y Zheng, Z Wang, Q Huang, X Cao, F Wang, S Liu
BACKGROUND: Recently, the 8th edition of the TNM classification of esophageal cancer has come up. The present study aims to compare the 7th and the proposed 8th edition of the AJCC/UICC TNM staging system for esophageal squamous cell carcinoma (ESCC). METHODS: A total of 1872 ESCC patients who underwent radical surgery with curative intent were analyzed retrospectively. Survival was analyzed using the Kaplan-Meier method, and values were compared using the log-rank test...
June 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28711918/prognostic-significance-of-the-size-and-number-of-lymph-nodes-on-pre-and-post-neoadjuvant-chemotherapy-ct-in-patients-with-pn0-esophageal-squamous-cell-carcinoma-a-5-year-follow-up-study
#9
Yong-Kun Chi, Ying Chen, Xiao-Ting Li, Ying-Shi Sun
The prognosis of patients with esophageal cancer improves by using neoadjuvant chemotherapy (NAC). More patients obtain pathological N0 staging (pN0) after surgery. The heterogeneity of prognosis of these patients poses a great challenge of customizing therapeutic strategies for individual patients. The signs of lymph nodes on both pre and post NAC computer tomography (CT) scan can provide more information for evaluation. Therefore, we investigated a new approach to lymph node (LN)-survival analysis by using pre-/post-NAC CT in pN0 esophageal cancer...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28705182/chemoradiation-in-elderly-esophageal-cancer-patients-rationale-and-design-of-a-phase-i-ii-multicenter-study-osage
#10
Stéphanie Servagi-Vernat, Gilles Créhange, Franck Bonnetain, Cécile Mertens, Etienne Brain, Jean François Bosset
BACKGROUND: The management of elderly patients with cancer is a therapeutic challenge and a public health problem. Definitive chemoradiotherapy (CRT) is an accepted standard treatment for patients with locally advanced esophageal cancer who cannot undergo surgery. However, there are few reports regarding tolerance to CRT in elderly patients. We previously reported results for CRT in patients aged ≥75 years. Following this first phase II trial, we propose to conduct a phase I/II study to evaluate the combination of carboplatin and paclitaxel, with concurrent RT in unresectable esophageal cancer patients aged 75 years or older...
July 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28704230/effect-of-esophageal-cancer-surgeon-volume-on-management-and-mortality-from-emergency-upper-gastrointestinal-conditions-population-based-cohort-study
#11
Sheraz R Markar, Hugh Mackenzie, Alan Askari, Omar Faiz, George B Hanna
OBJECTIVE: To study the influence of esophageal cancer surgeon volume upon mortality from upper gastrointestinal emergencies. BACKGROUND: Volume-outcome relationships led to the centralization of esophageal cancer surgery. METHODS: Hospital Episode Statistics data were used to identify patients admitted to hospitals within England (1997-2012). The influence of esophageal high-volume (HV) cancer surgeon status (≥5 resections per year) upon 30-day and 90-day mortality from esophageal perforation (EP), paraesophageal hernia causing obstruction or gangrene (PEH) and perforated peptic ulcer (PPU) was analyzed, independent of HV esophageal cancer center status and patient and disease-specific confounding factors...
July 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28700473/diagnostic-value-of-plasma-ngal-and-intraoperative-diuresis-for-aki-after-major-gynecological-surgery-in-patients-treated-within-an-intraoperative-goal-directed-hemodynamic-algorithm-a-substudy-of-a-randomized-controlled-trial
#12
Oliver Hunsicker, Aarne Feldheiser, Andreas Weimann, David Liehre, Jalid Sehouli, Klaus-Dieter Wernecke, Claudia Spies
Data on early markers for acute kidney injury (AKI) after noncardiovascular surgery are still limited. This study aimed to determine the diagnostic value of plasma neutrophil-gelatinase-associated lipocalin (pNGAL) and intraoperative diuresis for AKI in patients undergoing major abdominal surgery treated within a goal-directed hemodynamic algorithm.This study is a post-hoc analysis of a randomized controlled pilot trial comparing intravenous solutions within a hemodynamic goal-directed algorithm based on the esophageal Doppler in patients undergoing epithelial ovarian cancer surgery...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28690767/endoscopic-ultrasound-in-oncology-an-update-of-clinical-applications-in-the-gastrointestinal-tract
#13
REVIEW
Manuel Valero, Carlos Robles-Medranda
An accurate staging is necessary to select the best treatment and evaluate prognosis in oncology. Staging usually begins with noninvasive imaging such as computed tomography, magnetic resonance imaging or positron emission tomography. In the absence of distant metastases, endoscopic ultrasound plays an important role in the diagnosis and staging of gastrointestinal tumors, being the most accurate modality for local-regional staging. Its use for tumor and nodal involvement in pre-surgical evaluation has proven to reduce unnecessary surgeries...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28687396/the-impact-of-histology-on-recurrence-patterns-in-esophageal-cancer-treated-with-definitive-chemoradiotherapy
#14
Mian Xi, Cai Xu, Zhongxing Liao, Wayne L Hofstetter, Mariela Blum Murphy, Dipen M Maru, Manoop S Bhutani, Jeffrey H Lee, Brian Weston, Ritsuko Komaki, Steven H Lin
BACKGROUND: To assess the impact of histology on recurrence patterns and survival outcomes in patients with esophageal cancer (EC) treated with definitive chemoradiotherapy (CRT). METHODS: We analyzed 590 consecutive EC patients who received definitive CRT from 1998 to 2014, including 182 patients (30.8%) with squamous cell carcinoma (SCC) and 408 (69.2%) with adenocarcinoma. Recurrence pattern and timing, survival, and potential prognostic factors were compared...
July 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28685276/post-trimodality-expression-levels-of-metadherin-mtdh-as-a-prognostic-biomarker-for-esophageal-adenocarcinoma-patients
#15
Dilsa Mizrak Kaya, Xiaochuan Dong, Graciela M Nogueras-González, Yan Xu, Jeannelyn S Estrella, Kazuto Harada, Anthony Lopez, Fatemeh G Amlashi, Wayne L Hofstetter, Dipen M Maru, Quynh-Nhu Nguyen, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Jeremy J Erasmus, Irene Thomas, Jane E Rogers, Shumei Song, Jaffer A Ajani
Resectable esophageal adenocarcinoma (EAC) patients often receive chemoradiation followed by surgery. However, most patients experience recurrences. Overexpression of MTDH, an oncoprotein with multiple functions, has been found to be associated with poor prognosis in breast cancer, glioblastoma, melanoma and various gastrointestinal malignancies, but not in EAC. We sought to establish its role in resistant EAC (post-treatment residual EAC). MTDH was assessed by immunohistochemistry in resected EAC, and results were correlated with clinical outcomes...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28685086/outcomes-of-aggressive-treatment-in-esophageal-cancer-patients-with-synchronous-solitary-brain-metastasis
#16
Cem Onal, Berna Akkus Yildirim, Ozan Cem Guler
The aim of the present study was to investigate the outcomes of esophageal cancer (EC) patients with isolated synchronous brain oligometastasis (oligo-BM) treated with chemoradiotherapy (CRT) of the primary site and localized treatment of the BM with surgery, radiotherapy (RT) or radiosurgery. Of 125 EC patients investigated, seven patients (6%) had solitary BM. Six patients were diagnosed prior to, and one patient was diagnosed during, treatment. All patients were treated with neoadjuvant chemotherapy and whole-brain RT (WBRT) for BM...
July 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28683987/node-negative-esophageal-cancer-with-short-interval-isolated-metastasis-to-the-gallbladder-a-case-report
#17
Christopher M Hart, Kelly R Haisley, Christian Lanciault, James P Dolan
A 55 year old male smoker presented with clinical T3N0 esophageal adenocarcinoma of the GE junction. He completed neoadjuvant chemoradiotherapy with carboplatin/paclitaxel and 5040cGy of radiation. He had limited clinical response on restaging but no evidence of metastatic disease and completed a minimally invasive three field esophagectomy. This was complicated by a chyle leak requiring thoracic duct embolization from which he recovered well. Surgical pathology showed no apparent nodal disease or metastases but a poorly differentiated primary tumor with signet-cell features...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28683449/101-long-term-survivors-who-had-metastatic-gastroesophageal-cancer-and-received-local-consolidative-therapy
#18
Dilsa Mizrak Kaya, Xuemei Wang, Kazuto Harada, Mariela A Blum Murphy, Prajnan Das, Bruce D Minsky, Jeannelyn S Estrella, Quan Lin, Fatemeh G Amlashi, Jeffrey H Lee, Brian Weston, Manoop S Bhutani, Aurelio Matamoros, Tara Sagebiel, Carol C Wu, Jane E Rogers, Irene Thomas, Dipen M Maru, Heath D Skinner, Brian D Badgwell, Wayne L Hofstetter, Jaffer A Ajani
BACKGROUND: Through a multidisciplinary decision-making process, we developed a strategy of systemic therapy followed by local consolidative therapy (chemoradiation with/without surgery) in selected patients with metastatic gastroesophageal carcinoma (mGEAC). Only after a consensus during multidisciplinary discussions, local therapy was initiated. METHODS: We identified 101 patients with mGEAC who had local consolidation. We evaluated the association between various clinical variables (location of the primary, location of metastases, duration of initial chemotherapy, histologic grade, and radiation dose) and overall survival (OS)...
July 6, 2017: Oncology
https://www.readbyqxmd.com/read/28681978/video-assisted-thoracic-surgery-and-jejunal-reconstruction-in-a-case-of-situs-inversus-totalis-with-esophageal-cancer
#19
Kei Hosoda, Keishi Yamashita, Hiromitsu Moriya, Mitsuru Nemoto, Hiroaki Mieno, Akira Ema, Marie Washio, Masahiko Watanabe
A 78-year-old man with situs inversus totalis who had a previous history of distal gastrectomy for gastric cancer was referred to our hospital for treatment of esophageal cancer. He was diagnosed as cT2N0M0 and underwent video-assisted thoracic surgery and open completion gastrectomy with jejunal reconstruction via the ante-thoracic route. The postoperative period was uneventful except for transient palsy of the right recurrent laryngeal nerve. Based on a preoperative assessment of anatomical abnormality and an intraoperative adaptation to the mirror image of the standard procedure, video-assisted esophagectomy was considered safe and feasible...
July 6, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28675905/do-we-need-to-add-postoperative-radiotherapy-in-patients-undergoing-trimodality-therapy-for-esophageal-squamous-cell-carcinoma-with-positive-lymph-nodes-disease
#20
Pei-Ming Huang, Feng-Ming Hsu, Chia-Chi Lin, Chin-Hung Hsu, Jason Chia-Hsien Cheng, Jang-Ming Lee
BACKGROUND: The role of adjuvant radiotherapy for positive lymph nodes (LN) in patients with esophageal cancer who received neoadjuvant concurrent chemoradiotherapy (CCRT) is not well established. This study is aimed at determining the impact of positive LN and the survival benefit of postoperative radiotherapy (PORT) after CCRT plus surgery on esophageal cancer patients. METHODS: Seventy patients with positive LN after neoadjuvant CCRT followed by esophagectomy were enrolled in the study...
July 4, 2017: Digestive Surgery
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