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Esophageal cancer surgery

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https://www.readbyqxmd.com/read/29143085/clinical-significance-of-new-magnetic-resonance-thoracic-ductography-before-thoracoscopic-esophagectomy-for-esophageal-cancer
#1
Junya Oguma, Soji Ozawa, Akihito Kazuno, Miho Nitta, Yamato Ninomiya, Kentaro Yatabe, Tetsu Niwa, Takakiyo Nomura
BACKGROUND: Preoperative simulation of the thoracic duct using magnetic resonance thoracic ductography (MRTD) would enable a safe lymph node dissection near the thoracic duct and the prevention of chylothorax after an esophagectomy. The aim of this study was to determine whether MRTD is useful for preventing injury to the thoracic duct during surgery and for reducing the incidence of chylothorax after surgery. METHODS: We evaluated 130 patients who underwent preoperative MRTD followed by a thoracoscopic esophagectomy for the treatment of thoracic esophageal cancer between August 2014 and April 2017 (MRTD group)...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29135111/curative-intent-for-unresectable-advanced-squamous-cell-esophageal-cancer-overall-survival-after-chemoradiation
#2
Tatjana Arsenijevic, Marina Nikitovic, Vesna Plesinac-Karapandzic, Suzana Stojanovic-Rundic, Dusica Gavrilovic, Marjan Micev, Predrag Pesko
PURPOSE: To analyse the overall survival (OS) of patients with locally advanced, unresectable esophageal cancer treated with chemoradiation (CRT) with or without surgery. METHODS: CRT was administered to 63 patients with locally advanced (T3-4, N0-1), initially unresectable squamous cell esophageal cancer. After the assessment of tumor response to treatment, medically fit patients converted to operable stage were subjected to surgery. Regular follow-up was performed every 3 months during first 2 years, and then every 6 months...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134504/ketorolac-and-other-nsaids-increase-the-risk-of-anastomotic-leakage-after-surgery-for-gej-cancers-a-cohort-study-of-557-patients
#3
Kaare Terp Fjederholt, Cecilie Okholm, Lars Bo Svendsen, Michael Patrick Achiam, Jakob Kirkegård, Frank Viborg Mortensen
OBJECTIVE: The objective of this study is to investigate the impact of ketorolac and other nonsteroidal anti-inflammatory drugs on anastomotic leakage after surgery for gastro-esophageal-junction cancer. Within the last two decades, the incidence of gastro-esophageal-junction cancer has increased in the western world and surgery is the curative treatment modality of choice. Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality...
November 13, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29133255/high-prevalence-of-barrett-s-esophagus-and-esophageal-squamous-cell-carcinoma-after-repair-of-esophageal-atresia
#4
Floor W T Vergouwe, Hanneke IJsselstijn, Katharina Biermann, Nicole S Erler, René M H Wijnen, Marco J Bruno, Manon C W Spaander
BACKGROUND & AIMS: Esophageal atresia is rare, but improved surgical and intensive care techniques have increased rates of survival in children, so there are now many adults with this disorder. Many patients with esophageal atresia develop gastroesophageal reflux (GER), raising concerns about increased risk of Barrett's esophagus (BE; prevalence of 1.3%-1.6% in general population) and esophageal carcinoma. We assessed the prevalence of BE and esophageal carcinoma in this population. METHODS: We performed a prospective study of 289 patients with esophageal atresia at the Department of Gastroenterology and Hepatology at Erasmus MC University Medical Center in The Netherlands, from May 2012 through March 2017...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29130643/pilot-study-on-preventing-anastomotic-leakage-in-stapled-gastroesophageal-anastomosis
#5
Shijie Zhang, Weiming Huang, Xiangzheng Liu, Jian Li
BACKGROUND: This study explored how to improve the surgical technique to reduce or avoid anastomotic leakage. METHODS: From January 2012 to December 2016, 101 consecutive patients with cancer of the esophagus or gastroesophageal junction underwent stapled gastroesophageal anastomosis. The procedure included creating a tube-type stomach, fixing an inserted anvil, inspecting mucosa-to-mucosa alignment in the lumen under direct vision after firing the stapler, and, if found, manually repairing a rupture of the mucous membrane of the anastomosis...
November 11, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/29129092/adenocarcinoma-of-the-esophagus-controversies-and-consensus
#6
David H Ilson
Esophageal cancer, the sixth most common cause of cancer globally, is characterized by the development of early systemic metastatic disease. Adenocarcinoma of the esophagus and gastroesophageal junction (GEJ) is more common in the West. Preoperative chemotherapy or chemoradiotherapy is employed for locally advanced disease with contemporary studies suggesting higher rates of curative resection and reduced rates of local recurrence with the combination of chemotherapy and radiation therapy given prior to surgery...
October 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29129087/surgical-management-of-esophageal-cancer
#7
Raj G Vaghjiani, Daniela Molena
Esophageal cancer (EC) is an aggressive malignancy associated with an overall poor prognosis. The specific risk factors for EC vary by histologic type as well as geographic distribution but there is no widely applicable screening strategy to date. Patients can present with vague symptoms which can prove to be a diagnostic challenge. Furthermore, cases tend to present at a late stage, making therapeutic approach difficult. Despite ongoing changes in management strategy, surgery remains the only viable option for cure in early stage malignancy...
October 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29127549/preservation-of-the-celiac-branch-of-the-vagal-nerve-for-pylorus-preserving-gastrectomy-is-it-meaningful
#8
Haruna Furukawa, Manabu Ohashi, Michitaka Honda, Koshi Kumagai, Souya Nunobe, Takeshi Sano, Naoki Hiki
BACKGROUND: Preserving the hepatic and pyloric branches of the vagal nerve in laparoscopic pylorus-preserving gastrectomy (LPPG) is considered necessary to maintain the function of the pyloric cuff. However, the clinical benefits of preservation of the celiac branch of the vagal nerve (CBVN) remain unclear. METHODS: Of 391 patients who underwent LPPG for early gastric cancer, 116 patients in whom the CBVN was preserved (CBP group) and 58 patients in whom it was not preserved (non-CBP group) were selected through the propensity score-matching method...
November 10, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29126244/impact-of-neoadjuvant-chemoradiotherapy-on-health-related-quality-of-life-in-long-term-survivors-of-esophageal-or-junctional-cancer-results-from-the-randomized-cross-trial
#9
B J Noordman, M G E Verdam, S M Lagarde, J Shapiro, M C C M Hulshof, M I van Berge Henegouwen, B P L Wijnhoven, G A P Nieuwenhuijzen, J J Bonenkamp, M A Cuesta, J Th M Plukker, E J Spillenaar Bilgen, E W Steyerberg, A van der Gaast, M A G Sprangers, J J B van Lanschot
Background: Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard of care for patients with esophageal or junctional cancer, but the long-term impact of nCRT on health-related quality of life (HRQOL) is unknown. The purpose of this study is to compare very long-term HRQOL in long-term survivors of esophageal cancer who received nCRT plus surgery or surgery alone. Patients and methods: Patients were randomly assigned to receive nCRT (carboplatin/paclitaxel with 41...
November 6, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29125331/-18-fdg-pet-ct-is-useful-in-the-follow-up-of-surgically-treated-patients-with-esophageal-adenocarcinoma
#10
Sonia L Betancourt-Cuellar, Diana P Palacio, Carol C Wu, Brett W Carter, Arlene M Correa, Wayne L Hofstetter, Edith M Marom
PURPOSE: The purpose of this study was to evaluate FDG- PET/CT's performance in the follow-up of patients with surgically treated esophageal adenocarcinoma. MATERIAL AND METHODS: The follow-up FDG-PET/CT scans of 162 consecutive patients with surgically treated esophageal adenocarcinoma were retrospectively reviewed. Histopathological and/or imaging examinations confirmed recurrent disease. The accuracy, sensitivity, specificity, and negative and positive predictive values were calculated...
November 10, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29121243/a-structured-training-program-for-minimally-invasive-esophagectomy-for-esophageal-cancer-a-delphi-consensus-study-in-europe
#11
E Visser, P S N van Rossum, H van Veer, K Al-Naimi, M A Chaudry, M A Cuesta, S S Gisbertz, C A Gutschow, A H Hölscher, M D P Luyer, C Mariette, K Moorthy, G A P Nieuwenhuijzen, M Nilsson, J V Räsänen, P M Schneider, W Schröder, E Cheong, R van Hillegersberg
Evidence suggests that structured training programs for laparoscopic procedures can ensure a safe standard of skill acquisition prior to independent practice. Although minimally invasive esophagectomy (MIO) is technically demanding, no consensus on requirements for training for the MIO procedure exists. The aim of this study is to determine essential steps required for a structured training program in MIO using the Delphi consensus methodology. Eighteen MIO experts from 13 European hospitals were asked to participate in this study...
November 7, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29120138/high-tumor-stroma-proportion-is-a-worse-prognostic-factor-in-colorectal-cancer
#12
Josipa Flam, Damir Gugić, Mirta Benšić, Snježana Tomić, Jasmina Rajc
High stroma proportion appears to be a very important prognostic factor in esophageal and breast cancer. Previous researches have shown that it might have a similar effect on colorectal cancer. The aim of this study was to determine whether tumor stroma proportion influenced patient survival. This retrospective study included 236 patients with colorectal cancer having undergone surgery in 2006 and 2007 at Osijek University Hospital Center. Location with the highest stroma proportion at the site of deepest tumor invasion was determined...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29114598/long-term-survival-and-toxicity-outcomes-of-intensity-modulated-radiation-therapy-for-the-treatment-of-esophageal-cancer-a-large-single-institutional-cohort-study
#13
Anhui Shi, Zhongxing Liao, Pamela K Allen, Linus Ho, Mariela Blum Murphy, Dipen M Maru, Stephen G Swisher, Wayne L Hofstetter, Reza J Mehran, James D Cox, Ritsuko Komaki, Steven H Lin
Purpose: In patients with esophageal cancer (EC), intensity modulated radiation therapy (IMRT) improves dose sparing to the heart and lung, with some evidence showing clinical benefit. Herein, we report our cumulative clinical experience with the use of IMRT for EC. Methods and materials: This is a retrospective analysis of 587 patients with nonmetastatic EC who were treated consecutively with IMRT from January 2004 to June 30, 2013. All patients with stage I-IVA (American Joint Committee on Cancer 2002) received concurrent chemoradiation therapy either preoperatively or definitively...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114597/neoadjuvant-twice-daily-chemoradiotherapy-for-esophageal-cancer-treatment-related-mortality-and-long-term-outcomes
#14
Stuart E Samuels, Matthew H Stenmark, Jae Y Lee, Jonathan B McHugh, James A Hayman, Mark B Orringer, Susan G Urba, Libin Sun, Congying Xie, Feng-Ming Kong, Kyle C Cuneo
Objective: Because of the short potential doubling time of esophageal cancer, there is a theoretical benefit to using an accelerated radiation treatment schedule. This study evaluates outcomes and treatment-related mortality and morbidity of patients treated with neoadjuvant hyperfractionated accelerated chemoradiation for resectable esophageal cancer. Methods and materials: Outcomes from 250 consecutive patients with resectable esophageal cancer treated with preoperative hyperfractionated accelerated chemoradiotherapy (45 Gy in 30 twice-daily fractions over 3 weeks) followed by planned transhiatal esophagectomy were analyzed...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113654/the-role-of-intestinal-bacteria-in-the-development-and-progression-of-gastrointestinal-tract-neoplasms
#15
REVIEW
Kosuke Mima, Shuji Ogino, Shigeki Nakagawa, Hiroshi Sawayama, Koichi Kinoshita, Ryuichi Krashima, Takatsugu Ishimoto, Katsunori Imai, Masaaki Iwatsuki, Daisuke Hashimoto, Yoshifumi Baba, Yasuo Sakamoto, Yo-Ichi Yamashita, Naoya Yoshida, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
More than 100 trillion microorganisms inhabit the human intestinal tract and play important roles in health conditions and diseases, including cancer. Accumulating evidence demonstrates that specific bacteria and bacterial dysbiosis in the gastrointestinal tract can potentiate the development and progression of gastrointestinal tract neoplasms by damaging DNA, activating oncogenic signaling pathways, producing tumor-promoting metabolites such as secondary bile acids, and suppressing antitumor immunity. Other bacterial species have been shown to produce short-chain fatty acids such as butyrate, which can suppress inflammation and carcinogenesis in the gastrointestinal tract...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113389/psychiatric-morbidity-and-its-impact-on-surgical-outcomes-for-esophageal-and-gastric-cancer-patients-a-nationwide-cohort-study
#16
Huan Song, Jianwei Zhu, Donghao Lu, Fang Fang, Weimin Ye, Lars Lundell, Jan Johansson, Mats Lindblad, Magnus Nilsson
Background: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive. Results: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104871/smoking-gender-and-overweight-are-important-influencing-factors-on-monocytic-hla-dr-before-and-after-major-cancer-surgery
#17
Gunnar Lachmann, Clarissa von Haefen, Johannes Kurth, Fatima Yuerek, Klaus-Dieter Wernecke, Claudia Spies
Background: Monocytic human leukocyte antigen D related (mHLA-DR) is essential for antigen-presentation. Downregulation of mHLA-DR emerged as a general biomarker of impaired immunity seen in patients with sepsis and pneumonia and after major surgery. Influencing factors of mHLA-DR such as age, overweight, diabetes, smoking, and gender remain unclear. Methods: We analyzed 20 patients after esophageal or pancreatic resection of a prospective, randomized, placebo-controlled, double-blind trial (placebo group)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29102948/five-year-survival-after-surgical-removal-and-gamma-knife-stereotactic-radiosurgery-for-a-cerebellar-metastasis-from-an-esophagogastric-junction-cancer-a-case-report-and-literature-review
#18
Yoshikazu Kanazawa, Itsuo Fujita, Daisuke Kakinuma, Yuto Aoki, Hitoshi Kanno, Hiroki Arai, Kunihiko Matsuno, Tomohiro Shimoda, Takeshi Matsutani, Nobutoshi Hagiwara, Tsutomu Nomura, Takeshi Yamada, Shunji Kato, Zenya Naito, Hideaki Takasaki, Eiji Uchida
Brain metastases originating from esophageal or gastric cancer are rare, accounting for 2.1-3.3% of all brain tumors registered in Japan. There are no established therapeutic measures for brain metastases, which accordingly have a poor prognosis. We present here a patient who survived for 5 years after surgery and gamma knife treatment of a cerebellar metastasis from esophagogastric adenocarcinoma. The primary gastric cancer was treated by laparotomy with total gastrectomy, splenectomy, and D2 lymphadenectomy...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29098272/adjuvant-external-beam-radiotherapy-in-locally-advanced-differentiated-thyroid-cancer
#19
Samantha Tam, Moran Amit, Mongkol Boonsripitayanon, Maria E Cabanillas, Naifa L Busaidy, G Brandon Gunn, Stephen Y Lai, Neil D Gross, Erich M Sturgis, Mark E Zafereo
Importance: As incidence of differentiated thyroid cancer rises, treatment paradigms have become increasingly defined. Despite this, locally advanced disease continues to be challenging to manage. Postoperative therapy in the form of radioactive iodine (RAI) is generally recommended, but the role of external beam radiation therapy (EBRT) is less well defined. Objective: To investigate the role of EBRT in locally advanced differentiated thyroid cancer. Design, Setting, and Participants: For this retrospective cohort study, patients treated surgically for T4a differentiated thyroid cancer at the University of Texas MD Anderson Cancer Center from January 2000 through December 2015 were recruited, and 88 patients were included for analysis...
November 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29096345/hepatopancreatoduodenectomy-for-perihilar-cholangiocarcinoma-following-laparoscopic-total-gastrectomy
#20
Naokazu Chiba, Takahiro Gunji, Yosuke Ozawa, Kosuke Hikita, Toru Sano, Koichi Tomita, Yuta Abe, Shigeyuki Kawachi
INTRODUCTION: Surgical resection is the only curative treatment for perihilar cholangiocarcinoma. However, Hepatopancreatoduodenectomy (HPD) procedure remains controversial in regard to the balance between the survival benefit and high risk of mortality and morbidity. PRESENTATION OF CASE: A 72-year-old man who was revealed the dilation of intrahepatic hepatic duct by computed tomography after laparoscopic total gastrectomy was referred to our hospital. The patient had undergone laparoscopic total gastrectomy with Roux-en-Y esophageal-jejunostomy reconstruction 1year previously...
October 27, 2017: International Journal of Surgery Case Reports
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