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Esophageal cancer surgery

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https://www.readbyqxmd.com/read/29781362/the-era-of-the-large-databases-outcomes-after-gastroesophageal-surgery-according-to-nsqip-nis-and-ncdb-databases-systematic-literature-review
#1
Gabriela Batista Rodríguez, Andrea Balla, Sonia Fernández-Ananín, Carmen Balagué, Eduard M Targarona
BACKGROUND: The term big data refers to databases that include large amounts of information used in various areas of knowledge. Currently, there are large databases that allow the evaluation of postoperative evolution, such as the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP), the Healthcare Cost and Utilization Project (HCUP) National Inpatient Sample (NIS), and the National Cancer Database (NCDB). The aim of this review was to evaluate the clinical impact of information obtained from these registries regarding gastroesophageal surgery...
May 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29781107/pristimerin-targeting-nf-%C3%AE%C2%BAb-pathway-inhibits-proliferation-migration-and-invasion-in-esophageal-squamous-cell-carcinoma-cells
#2
Yuanqing Tu, Fuxing Tan, Jingfeng Zhou, Jingxuan Pan
Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer-related death with poor prognosis in China. Identifying novel targeted therapies in ESCC is urgently needed. The aberrant activation of NF-κB signalling pathway is critical for prognosis and recurrence of ESCC, which make it a potential target in the treatment of ESCC. Here, we found that pristimerin inhibited ESCC cell proliferation, migration, invasion, induced cell apoptosis, and eliminated cancer stem-like cells (CSCs). It also showed a synergistic effect on ESCC when combined with 5-fluorouracil (5-FU)...
May 20, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29780831/impact-exerted-by-nutritional-risk-screening-on-clinical-outcome-of-patients-with-esophageal-cancer
#3
Rui Wang, Hongfei Cai, Yang Li, Caiwen Chen, Youbin Cui
Objective: Preoperative nutritional status of patients is closely associated with their recovery after the surgery. This study aims to ascertain the impact exerted by the nutritional risk screening on clinical outcome of patients with esophageal cancer. Methods: 160 patients with esophageal cancer aged over 60, having got therapy at the First Hospital of Jilin University from Jun 2016 to Feb 2017 were evaluated by adopting the NRS2002. 80 cases of patients got active therapy of nutritional support, and the other patients not supported nutritionally were selected as the control group...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29774930/-advertent-problems-about-gastric-stump-cancer-surgery
#4
Han Liang
Due to different disease background of gastric stump cancer(GSC) patients (benign or malignant lesion, reconstruction of digestive tract, etc.), the GSC surgical procedure and the difficulty of lymphadenectomy are also different. The extent of radical lymphadenectomy for gastric stump cancer should extend beyond D2 lymphadenectomy, according to the different backgrounds of initial disease, reconstructions, and tumor location. A lymphadenectomy should include the lymph nodes in anterior (No.17) and posterior (No...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774390/-oligometastases-in-gastric-and-esophageal-cancer-current-clinical-trials-and-surgical-concepts
#5
REVIEW
S Beckert, A Königsrainer
There is an increasing role of surgery even in metastatic tumor stages. In colorectal cancer patients with limited metastases, complete cytoreduction is able to offer long-term survival in synchronic as well as metachronic situations. In tumors of the upper gastrointestinal tract (UGIT), however, the impact of surgery in metastatic disease remains to be clarified. Even though several retrospective studies suggest prolonged survival, surgery is not recommended by the current German S3 guidelines for tumors of the UGIT...
May 17, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29769143/clinical-outcome-of-elderly-patients-%C3%A2-70-years-with-esophageal-cancer-undergoing-definitive-or-neoadjuvant-radio-chemo-therapy-a-retrospective-single-center-analysis
#6
Franziska Walter, David Böckle, Nina-Sophie Schmidt-Hegemann, Rebecca Köpple, Sabine Gerum, Stefan Boeck, Martin Angele, Claus Belka, Falk Roeder
BACKGROUND: To analyse the outcome of elderly patients (≥70 years) with esophageal cancer treated with curative intent radio(chemo)therapy. METHODS: Fifty five patients (median 75 years) receiving curative intent radio(chemo)therapy for esophageal cancer from 1999 to 2015 were retrospectively analyzed. Most patients showed locally advanced disease (T3/4:78%, N+:58%) with squamous cell histology (74%). Charlson comorbidity score was > 1 in 27%. 48 patients (87%) received definitive treatment while 7 patients were treated neoadjuvantly...
May 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29766228/relationship-between-visceral-obesity-and-postoperative-inflammatory-response-following-minimally-invasive-esophagectomy
#7
Akihiko Okamura, Masayuki Watanabe, Ian Fukudome, Kotaro Yamashita, Masami Yuda, Masaru Hayami, Yu Imamura, Shinji Mine
BACKGROUND: Esophagectomy for esophageal cancer is one of the most invasive surgeries. However, the factors influencing postoperative systemic inflammatory response following esophagectomy have not been elucidated. Recently, visceral fat has been shown to play an important role in both chronic and acute inflammation. In this study, we assessed the relationship between visceral obesity and postoperative inflammatory response following minimally invasive esophagectomy (MIE). METHODS: Visceral fat area (VFA) was measured using computed tomography in 152 patients undergoing MIE for esophageal cancer...
May 15, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29761863/surgical-treatment-of-esophageal-cancer-in-the-era-of-multimodality-management
#8
REVIEW
Alicia S Borggreve, B Feike Kingma, Serg A Domrachev, Mikhail A Koshkin, Jelle P Ruurda, Richard van Hillegersberg, Flavio R Takeda, Lucas Goense
Over the last decades, the treatment of resectable esophageal cancer has evolved into a multidisciplinary process in which all players are essential for treatment to be successful. Medical oncologists and radiation oncologists have been increasingly involved since the implementation of neoadjuvant therapy, which has been shown to improve survival. Although esophagectomy is still considered the cornerstone of curative treatment for locally advanced esophageal cancer, it remains associated with considerable postoperative morbidity, despite promising results of minimally invasive techniques...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29757780/effects-of-intraoperative-opioid-use-on-recurrence-free-and-overall-survival-in-patients-with-esophageal-adenocarcinoma-and-squamous-cell-carcinoma
#9
Kim N Du, Lei Feng, Abigail Newhouse, Jeel Mehta, Javier Lasala, Gabriel E Mena, Wayne L Hofstetter, Juan P Cata
BACKGROUND: Perioperative opioid use is associated with poor survival in patients with esophageal squamous cell carcinoma. The most common histological type of esophageal cancer in western countries is adenocarcinoma. The objective of this study was to evaluate the association between intraoperative opioid consumption and survival in patients with adenocarcinoma and squamous cell carcinoma of the esophagus. METHODS: Records of patients who had undergone esophageal cancer surgery between January 2000 and January 2017 were reviewed...
May 10, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29753503/novel-esophageal-reconstruction-technique-via-transmediastinal-route-from-posterior-to-anterior-mediastinum-after-esophagectomy
#10
Takushi Yasuda, Osamu Shiraishi, Mitsuru Iwama, Tomoki Makino, Hiroaki Kato, Yutaka Kimura
BACKGROUND: The incidence of metachronous esophageal squamous cell cancer (ESCC) after head and neck cancer (HNC) and in elderly patients has increased. Both elderly ESCC patients and ESCC patients after HNC surgery are at potential risk for dysphagia, and for the latter, surgery in the neck is difficult. An intrathoracic anastomosis that bypasses the cervical procedure is preferable to preserve swallowing function and reduce surgical risk. In gastrectomized patients, because the stomach cannot be used as a substitute, securing graft blood supply is critical, but microvascular anastomosis cannot be easily added in procedures for intrathoracic posterior mediastinal reconstruction...
April 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29752721/can-endoscopic-resection-for-barrett-s-dysplasia-and-early-cancer-be-curative
#11
REVIEW
Shai Friedland, George Triadafilopoulos
Effective endoscopic treatments for dysplasia and early (intramucosal) cancer, together with expanded and rigorous screening programs to detect Barrett's esophagus, could help reverse the increase in the incidence of esophageal cancer and reduce esophageal cancer-related mortality. In this review, we discuss the long-term outcomes for mucosal resection for dysplasia and early cancer and compares them to esophagectomy as the standard of care choice. Eendoscopic resection for Barrett's dysplasia and early cancer can be curative but only when the lesion can be classified as: Paris type I (polypoid); Paris IIa (slightly elevated); Paris IIb (flat); Paris IIc (slightly depressed); histological grades G1 and G2; high-grade dysplasia...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29750981/comparison-of-endoscopic-submucosal-dissection-and-surgery-for-superficial-esophageal-squamous-cell-carcinoma-a-propensity-score-matched-analysis
#12
Yang Won Min, Hyuk Lee, Byeong Geun Song, Byung-Hoon Min, Hong Kwan Kim, Yong Soo Choi, Jun Haeng Lee, Na-Young Hwang, Keumhee C Carriere, Poong-Lyul Rhee, Jae J Kim, Jae Ill Zo, Young Mog Shim
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). However, long-term outcomes of ESD and esophagectomy for SESCC have not been compared. We compared the clinical outcomes of ESD and esophagectomy in a matched cohort. METHODS: Patients who underwent ESD and esophagectomy for SESCC were included. We selected SESCCs without obvious submucosal invasion from the surgical database by reviewing endoscopic images...
May 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29748890/the-negative-survival-impact-of-infectious-complications-after-surgery-is-canceled-out-by-the-response-of-neoadjuvant-chemotherapy-in-patients-with-esophageal-cancer
#13
Kazuki Kano, Toru Aoyama, Takaki Yoshikawa, Yukio Maezawa, Tetsushi Nakajima, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Haruhiko Cho, Takashi Ogata
BACKGROUND: This study was designed to investigate whether postoperative infectious complications (ICs) are a risk factor for the prognosis in esophageal cancer patients who receive neoadjuvant chemotherapy by stratifying the response to neoadjuvant chemotherapy. METHODS: The present study retrospectively examined patients who received neoadjuvant chemotherapy followed by esophagectomy between January 2011 and September 2015. Risk factors for overall survival (OS) were examined by Cox proportional hazard analyses...
May 10, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29747950/esophagectomy-in-patients-with-human-immunodeficiency-virus-and-acquired-immune-deficiency-syndrome-a-viable-option
#14
Michael Mwachiro, Eric Mitchell, Hillary M Topazian, Russell White
The objective of this study was to assess the outcomes for patients with human immunodeficiency virus (HIV) and acquired immune deficiency virus (AIDS) who had esophagectomy done for both benign and malignant conditions. A retrospective chart review of patients with HIV and AIDS undergoing esophagectomy at a rural referral hospital was done for the period of 2009-2014. Patient postoperative complications, outcomes, and follow-up data were charted. All procedures were done by a single lead surgeon. Nine patients met the study criteria, 7 of whom had esophageal cancer, and 2 with strictures...
April 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29747255/-endoscopic-screening-for-upper-gastrointestinal-second-primary-malignancies-in-patients-with-hypopharyngeal-squamous-cell-carcinoma
#15
J J Tian, W Xu, Z H Lyu, J K Ma, P Cui, N Sa, H Y Cao
Objective: To evaluate the usefullness of flexible esophagoscopy and chromoendoscopy with Lugol's solution in the detection of synchronous esophageal neoplasm in patients with hypopharyngeal squamous cell carcinoma (HSCC). Methods: A retrospective review of 96 cases with HSCC that received surgical treatment from March 2016 to March 2017 was accomplished. In these patients, the site of origin were pyriform sinus ( n =75), posterior pharyngeal wall ( n =11) and postcricoid ( n =10). Esophagoscopy was prospectively performed on all patients before treatment for HSCC...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29742891/clinical-analysis-of-117-cases-with-synchronous-multiple-primary-esophageal-squamous-cell-carcinomas
#16
Zhiqin Chen, Sihan Li, Zheng He, Guang Li
Background/Aims: We aimed to study the clinical characteristics, treatment modality, and the prognosis of synchronous multiple primary esophageal squamous cell carcinomas (SMPESCC). Methods: A total of 117 SMPESCC cases were evaluated retrospectively from 2010 to 2015. Results: The most common locations of SMPESCC were mid- and lower thoracic segments (n = 208, 84.9%). The 1-, 2-, and 3-year overall survival rates were 53.8%, 30.8%, and 15...
May 11, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29741233/surgical-robotics-for-esophageal-cancer
#17
Peter P Grimminger, Sylvia van der Horst, Jelle P Ruurda, Marc van Det, Philippe Morel, Richard van Hillegersberg
We present an update on robotic techniques and their advantages and use in esophageal cancer surgery. Recent work has shown tremendous progress in robotic-assisted minimally invasive esophagectomy (RAMIE) and lymphadenectomy for esophageal cancer, as well as benefits of robotic surgery in high upper esophageal tumors and T4b disease. We discuss the different RAMIE techniques, especially for intrathoracic anastomosis. The ongoing ROBOT trial had demonstrated superiority of robotic esophageal cancer surgery over open esophagectomy...
May 9, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29738752/neutrophil-to-lymphocyte-ratio-as-predictor-of-treatment-response-in-esophageal-squamous-cell-cancer
#18
Arianna Barbetta, Tamar B Nobel, Smita Sihag, Meier Hsu, Kay See Tan, Manjit S Bains, James M Isbell, Yelena Y Janjigian, Abraham J Wu, Matthew J Bott, David R Jones, Daniela Molena
BACKGROUND: The aim of this study was to assess the variation of NLR (ΔNLR), before and after chemoradiotherapy, as a predictor of treatment response and a prognostic factor for recurrence and disease-free survival (DFS) in patients with esophageal squamous cell cancer (ESCC) treated with chemoradiotherapy with or without surgery. METHODS: Patients with locally advanced ESCC, treated with chemoradiation with and without surgery that had a complete blood count, before and after chemoradiotherapy, were included...
May 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29733012/robotic-approach-in-benign-and-malignant-esophageal-tumors-a-preliminary-seven-case-series
#19
Victor Tomulescu, Codrut Stanescu, Cristian Blajut, Loredana Barbulescu, Gabriela Droc, Vlad Herlea, Irinel Popescu
Esophageal surgery has been recognized as very challenging for surgeons and risky for patients. Thoracoscopic approach have proved its benefit in esophageal surgery but has some drawbacks as tremor and limited degrees of freedom, contra-intuitive movements and fulcrum effect of the surgical tools. Robotic technology has been developed with the intent to overcome these limitations of the standard laparoscopy or thoracoscopy. These benefits of robotic procedure are most advantageous when operating in remote areas difficult to reach as in esophageal surgery...
March 2018: Chirurgia
https://www.readbyqxmd.com/read/29730913/-clinic-features-and-prognostic-analysis-for-t1-esophagus-cancer
#20
Z Yu, X M Li, M Huai, G J Lu, C Wang, Q Y Wang, Q Y Liu
Objective: To investigate relationship between the clinicopathological features and prognosis of T1 esophageal carcinoma. Methods: Data from 212 T1 primary esophageal cancer patients, who underwent radical surgery in The Fourth Hospital of Hebei Medical University from Jan 2001 to Dec 2009 were enrolled. There were 148 males and 64 females. There were 91 patients with stage pT1a and 121 patients with stage pT1b. Results: The survival of the 212 patients was 27~108 months, and the median survival was 80.8 months...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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