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Esophageal cancer surgery

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https://www.readbyqxmd.com/read/28537901/inflammatory-cytokines-are-associated-with-response-and-prognosis-in-patients-with-esophageal-cancer
#1
Susanne Blank, Henrik Nienhüser, Lena Dreikhausen, Leila Sisic, Ulrike Heger, Katja Ott, Thomas Schmidt
BACKGROUND: Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The tumor microenvironment and circulating factors as possible predictors of response and prognosis gain interest. This study aimed to investigate cytokines in patients' serum and tumor tissue with regard to response and prognosis. RESULTS: Median survival between SCC and AC was not different (published previously)...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28532174/subsequent-thoracic-cancers-among-patients-diagnosed-with-lung-cancer-a-seer-database-analysis
#2
Omar Abdel-Rahman, Winson Cheung
BACKGROUND: Population-based data on the development of subsequent thoracic cancers following the initial diagnosis of lung cancer are scarce. We evaluated this clinical scenario in lung cancer patients registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database (1988-2013) was queried using the SEER*Stat program to determine the clinico-pathological features of lung cancer patients who develop subsequent thoracic cancers as well as the characteristics of these subsequent cancers...
May 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28529190/development-and-evaluation-of-an-interdisciplinary-postoperative-support-program-in-outpatient-clinics-after-thoracic-esophagectomy
#3
Takeo Fujita, Yoko Iida, Chihau Tanaka, Kumi Nakamura, Keiko Yamanaka, Junya Ueno, Yoshie Iino, Chitose Haruka, Hatoe Sakamoto, Hiroyuki Daiko
BACKGROUND: To support patients discharged from the hospital after surgery, we launched an "Interdisciplinary Postoperative Support Program" in outpatient clinics for patients who were discharged within 1 month after thoracic esophagectomy and their families. We introduce our program and clarify the patient's physical and psychologic status by analyzing the questionnaire provided from this program. MATERIALS AND METHODS: From August 2014 to January 2015, we conducted the Interdisciplinary Postoperative Support Program every month...
May 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28527619/chemoradiotherapy-for-esophageal-cancer-before-or-after-surgery-it-is-not-just-a-matter-of-time
#4
EDITORIAL
Simon R Turner, Daniela Molena
No abstract text is available yet for this article.
April 28, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28511234/indications-results-and-clinical-impact-of-endoscopic-ultrasound-eus-guided-sampling-in-gastroenterology-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline-updated-january-2017
#5
Jean-Marc Dumonceau, Pierre H Deprez, Christian Jenssen, Julio Iglesias-Garcia, Alberto Larghi, Geoffroy Vanbiervliet, Guruprasad P Aithal, Paolo G Arcidiacono, Pedro Bastos, Silvia Carrara, László Czakó, Gloria Fernández-Esparrach, Paul Fockens, Àngels Ginès, Roald F Havre, Cesare Hassan, Peter Vilmann, Jeanin E van Hooft, Marcin Polkowski
For pancreatic solid lesions, ESGE recommends performing endoscopic ultrasound (EUS)-guided sampling as first-line procedure when a pathological diagnosis is required. Alternatively, percutaneous sampling may be considered in metastatic disease.Strong recommendation, moderate quality evidence.In the case of negative or inconclusive results and a high degree of suspicion of malignant disease, ESGE suggests re-evaluating the pathology slides, repeating EUS-guided sampling, or surgery.Weak recommendation, low quality evidence...
May 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/28510809/transcatheter-arterial-embolization-for-intercostal-arterio-esophageal-fistula-in-esophageal-cancer
#6
Tetsuya Tajima, Shigeo Haruki, Shinsuke Usui, Koji Ito, Akiyo Matsumoto, Akiyuki Matsuhisa, Noriaki Takiguchi
BACKGROUND: While esophageal fistula formation in the adjacent organs is associated with high rates of morbidity and mortality, the management of non-aortic arterio-esophageal fistula has not been frequently reported. CASE PRESENTATION: A 69-year-old Japanese man who had undergone definitive chemoradiotherapy for esophageal cancer was admitted to our hospital with hematemesis. He was diagnosed with mediastinal abscess caused by esophageal perforation, and esophageal bypass surgery was performed...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28510611/mmp-10-mmp-7-timp-1-and-timp-2-mrna-expression-in-esophageal-cancer
#7
Agnieszka Juchniewicz, Oksana Kowalczuk, Robert Milewski, Wojciech Laudański, Piotr Dzięgielewski, Mirosław Kozłowski, Jacek Nikliński
INTRODUCTION: Tissue inhibitors of metalloproteinases (TIMP) and the matrix metalloproteinases (MMP) are involved in the spread of cancer. METHODS: We have evaluated the matrix metalloproteinases' (MMP-10, MMP-7) and their inhibitors' (tissue inhibitors of metalloproteinases - TIMP-1, TIMP-2) mRNA expression in 61 esophageal cancer samples from patients who had undergone surgery, by using real-time quantitative RT-PCR, and correlated the results with the patient clinicopathologic features...
May 15, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28505401/the-influence-of-a-composite-hospital-volume-on-outcomes-for-gastric-cancer-surgery-a-dutch-population-based-study
#8
Linde A D Busweiler, Johan L Dikken, Daniel Henneman, Mark I van Berge Henegouwen, Vincent K Y Ho, Rob A E M Tollenaar, Michel W J M Wouters, Johanna W van Sandick
BACKGROUND: Volume-outcome associations for complex surgical procedures have motivated centralization of care worldwide. The aim of this study was to investigate the association between overall hospital experience with complex upper gastrointestinal (GI) cancer resections and outcomes after gastric cancer surgery. METHODS: Data on all patients (n = 4837) who underwent a resection for non metastatic invasive gastric cancer between 2005 and 2014 were obtained from the Netherlands Cancer Registry (NCR)...
May 15, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28504587/a-single-intercostal-space-thoracoscopic-approach-for-minimally-invasive-ivor-lewis-esophagectomy
#9
Saibo Pan, Lian Wang, Ming Wu, Qi Wang, Gang Shen, Gang Chen
OBJECTIVE: We present a laparoscopic and single intercostal space thoracoscopic approach (SICS group) for Ivor Lewis minimally invasive esophagectomy (MIE) and provide postoperative analgesia with a continuous multiple intercostal nerve blocking technique. The characters of this technique are evaluated. MATERIALS AND METHODS: From October 2015 to April 2016, 18 consecutive patients with esophageal cancer were treated with Ivor Lewis MIE by a SICS group. Moreover, from July 2014 to September 2015, 48 patients with esophageal cancer received Ivor Lewis MIE by four-port video-assisted thoracic surgery (VATS) approach...
May 15, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28501085/staging-in-esophageal-and-gastric-cancers
#10
REVIEW
Thomas Hayes, Elizabeth Smyth, Angela Riddell, William Allum
Gastric and esophageal tumors have a poor prognosis; approximately 15% of patients are alive at 10 years following diagnosis. Surgical resection plus adjunctive chemotherapy or chemoradiotherapy is curative in approximately 50% of patients with operable disease, but is also associated with significant morbidity. Therefore, accurate preoperative staging is required to spare patients unnecessary toxicity and futile surgery. This review evaluates the sensitivity and specificities of the modalities used to stage patients with gastroesophageal cancer...
June 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/28499662/-acute-toxicity-of-breast-cancer-irradiation-with-modulated-intensity-by-tomotherapy-%C3%A2
#11
N Aoulad, C Massabeau, B de Lafontan, L Vieillevigne, G Hangard, C Ciprian, L Chaltiel, É Moyal, F Izar
PURPOSE: Helical radiation intensity modulated by tomotherapy improves dose distribution to complex and large volumes. The aim of the study was to assess acute toxicity of this technique during breast cancer irradiation after conserving surgery or mastectomy. PATIENTS AND METHODS: Cutaneous toxicities, lung and oesophageal side effects, and breast lymphedema were retrospectively collected according to the Common Terminology Criteria for Adverse Events Version 4...
May 9, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28498235/hospital-minimally-invasive-surgery-utilization-for-gastrointestinal-cancer
#12
Meredith C Mason, Hop S Tran Cao, Samir S Awad, Farhood Farjah, George J Chang, Nader N Massarweh
OBJECTIVE: The aim of the study was to evaluate the impact of receiving care at high minimally invasive surgery (MIS)-utilizing hospitals BACKGROUND:: MIS techniques are used across surgical specialties. The extent of MIS utilization for gastrointestinal (GI) cancer resection and impact of receiving care at high utilizing hospitals is unclear. METHODS: This is a retrospective cohort study of 137,581 surgically resected esophageal, gastric, pancreatic, hepatobiliary, colon, and rectal cancer patients within the National Cancer Data Base (2010-2013)...
May 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28496456/swallowing-disorders-after-oral-cavity-and-pharyngolaryngeal-surgery-and-role-of-imaging
#13
REVIEW
Caterina Giannitto, Lorenzo Preda, Valeria Zurlo, Luigi Funicelli, Mohssen Ansarin, Salvatore Di Pietro, Massimo Bellomi
Head and neck squamous cell carcinoma is the sixth most common cancer diagnosed worldwide and the eighth most common cause of cancer death. Malignant tumors of the oral cavity, oropharynx, and larynx can be treated by surgical resection or radiotheraphy with or without chemotheraphy and have a profound impact on quality of life functions, including swallowing. When surgery is the chosen treatment modality, the patient may experience swallowing impairment in the oral and pharyngeal phases of deglutition. A videofluoroscopic study of swallow enables the morphodynamics of the pharyngeal-esophageal tract to be accurately examined in patients with prior surgery...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28491289/recent-advances-in-preoperative-management-of-esophageal-adenocarcinoma
#14
REVIEW
Kazuto Harada, Dilsa Mizrak Kaya, Hideo Baba, Jaffer A Ajani
Esophageal cancer is an aggressive malignancy with increasing incidence, and the prognosis of patients treated by surgery alone remains dismal. Preoperative treatment can modestly prolong overall survival. Preoperative chemotherapy or chemoradiation is the standard of care for resectable esophageal cancer (greater than clinical stage I and less than clinical stage IV). One of the challenges is to predict complete response in the surgical specimen from preoperative therapy and to avoid surgery in some patients but also predict ineffectiveness of preoperative therapy if the tumor is resistant and avoid such therapies altogether...
2017: F1000Research
https://www.readbyqxmd.com/read/28486551/survival-comparison-between-radical-surgery-and-definitive-chemoradiation-in-267-esophageal-squamous-cell-carcinomas-in-a-single-institution-a-propensity-matched-study
#15
Hideomi Yamashita, Yasuyuki Seto, Ryousuke Takenaka, Kae Okuma, Tomoki Kiritooshi, Kazuhiko Mori, Kazuhiko Yamada, Takashi Fukuda, Michio Kaminishi, Osamu Abe, Keiichi Nakagawa
OBJECTIVE: To compare radical surgery with definitive chemoradiation (CRT) for esophageal squamous cell carcinoma using propensity score (PS) matching at our single institution. MATERIALS AND METHODS: A total of 386 consecutive, surgically treated and 243 CRT-treated cases between 2001 and 2014 were analyzed. PS was calculated using multivariable analysis (logistic regression) for pairs of variables such as treatment time, age, sex, primary tumor location, clinical stage, and clinical T- and N-stage for patients after excluding clinical T4 and M1 cases...
2017: PloS One
https://www.readbyqxmd.com/read/28484837/what-should-we-expect-from-robotic-surgery-for-second-primary-oropharyngeal-cancer
#16
Tuan-Jen Fang, Li-Ang Lee, Bing-Shan Huang, Chien-Yu Lin, Cheng-Lung Hsu, Joseph Tung-Chieh Chang, Tzu-Chen Yen, Chun-Ta Liao, Hui-Chen Chiang
The outcomes of second primary oropharyngeal cancer (SPOPC) may not be determined by oropharyngeal cancer but from the other index cancer as well. The management of (SPOPC) remains inconclusive and limited. Transoral robotic surgery (TORS) to maximize the functional outcomes without reducing oncologic effect is suggested as the primary treatment for selected oropharyngeal cancer. This study aimed to evaluate the feasibility and outcomes of TORS for the management of SPOPC. Patients who underwent TORS from January 2011 to June 2015 at a tertian referral center in Taiwan were recruited...
May 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28477332/a-case-of-long-term-survival-after-surgical-resection-for-solitary-adrenal-recurrence-of-esophageal-squamous-carcinoma
#17
Nobuhiko Kanaya, Kazuhiro Noma, Tsuyoshi Okada, Naoaki Maeda, Shunsuke Tanabe, Kazufumi Sakurama, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
BACKGROUND: Esophageal carcinomas are highly malignant tumors with a high frequency of lymph node and distant organ metastasis. Treatment for recurrent tumors is generally decided on an individual basis. Although multidisciplinary treatments involving chemotherapy, surgical resection, and radiation are performed, the prognosis remains poor. Here, we report a case of prolonged recurrence-free survival (38 months) after esophageal carcinoma surgery and subsequent laparoscopic adrenalectomy for right adrenal metastasis...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28475748/associations-of-carboxypeptidase-4-with-aldh1a1-expression-and-their-prognostic-value-in-esophageal-squamous-cell-carcinoma
#18
L Sun, J Cao, C Guo, J Burnett, Z Yang, Y Ran, D Sun
Esophageal cancer is an aggressive disease with poor prognosis because of early metastasis when diagnosed and recurrence after surgery. This study is aimed at investigating the expression of carboxypeptidaseA4 (CPA4) and aldehyde dehydrogenase 1A1 (ALDH1A1) in esophageal squamous cell carcinoma (ESCC) tumor tissues and analyzed their association and clinical significance. The expression of CPA4 and ALDH1A1 was determined by immunohistochemistry using the corresponding primary antibodies on two commercial tissue arrays...
June 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28475745/impact-of-visceral-obesity-and-metabolic-syndrome-on-the-postoperative-immune-inflammatory-and-endocrine-response-following-surgery-for-esophageal-adenocarcinoma
#19
S L Doyle, A M Mongan, C L Donohoe, G P Pidgeon, M Sherlock, J V Reynolds, J Lysaght
Visceral obesity and metabolic syndrome (MetSyn) represent a constellation of inflammation, insulin resistance, and hyperglycemia and are established risk factors for gastrointestinal cancer. However, their impact on the immune and inflammatory response after major upper gastrointestinal oncologic surgery is unknown. In 125 consecutive patients who underwent esophagectomy, C-reactive protein (CRP) and CRP:albumin levels were recorded preoperatively and on days 1, 3, 7, and 14 postoperatively. In a subset of 30 patients, circulating levels of IL-6, IL-8, IL-10, IL-12p70, IFN-γ, TNF-α, TGF-β, and cortisol were measured...
June 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28475728/a-retrospective-comparison-of-neoadjuvant-chemoradiotherapy-regimens-for-locally-advanced-esophageal-cancer
#20
N N Sanford, P J Catalano, P C Enzinger, B L King, R Bueno, N E Martin, T S Hong, J Y Wo, H J Mamon
Preoperative chemoradiotherapy (CRT) with carboplatin/paclitaxel has been shown to increase survival in patients with esophageal cancer, including gastroesophageal junction (GE) junction cancer, over surgery alone; however, there have been no studies comparing the different neoadjuvant CRT regimens. We retrospectively evaluated the long-term results of trimodality therapy for patients with locally advanced esophageal cancer treated on several chemotherapy regimens. Between 1999 and 2014, 215 patients with locally advanced esophageal cancer underwent neoadjuvant CRT followed by surgical resection...
July 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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