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https://www.readbyqxmd.com/read/29675003/role-of-micrornas-and-exosomes-in-helicobacter-pylori-and-epstein-barr-virus-associated-gastric-cancers
#1
REVIEW
Iva Polakovicova, Sofia Jerez, Ignacio A Wichmann, Alejandra Sandoval-Bórquez, Nicolás Carrasco-Véliz, Alejandro H Corvalán
Emerging evidence suggests that chronic inflammation caused by pathogen infection is connected to the development of various types of cancer. It is estimated that up to 20% of all cancer deaths is linked to infections and inflammation. In gastric cancer, such triggers can be infection of the gastric epithelium by either Helicobacter pylori ( H. pylori ), a bacterium present in half of the world population; or by Epstein-Barr virus (EBV), a double-stranded DNA virus which has recently been associated with gastric cancer...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29669762/yap-taz-initiates-gastric-tumorigenesis-via-upregulation-of-myc
#2
Wonyoung Choi, Jeongsik Kim, Jaeoh Park, Da-Hye Lee, Daehee Hwang, Jeong-Hwan Kim, Hassan Ashktorab, Duane T Smoot, Seon-Young Kim, Chan Choi, Gou Young Koh, Dae-Sik Lim
YAP and TAZ play oncogenic roles in various organs, but the role of YAP/TAZ in gastric cancer remains unclear. Here we show that YAP/TAZ activation initiates gastric tumorigenesis in vivo and verify its significance in human gastric cancer. In mice, YAP/TAZ activation in the pyloric stem cell led to step-wise tumorigenesis. RNA sequencing identified MYC as a decisive target of YAP, which controls MYC at transcriptional and post-transcriptional levels. These mechanisms tightly regulated MYC in homeostatic conditions, but YAP activation altered this balance by impeding miRNA processing, causing a shift towards MYC upregulation...
April 18, 2018: Cancer Research
https://www.readbyqxmd.com/read/29668670/exosomes-released-by-gastric-cancer-cells-induce-transition-of-pericytes-into-cancer-associated-fibroblasts
#3
Xiaofei Ning, Hongran Zhang, Cong Wang, Xiuqi Song
BACKGROUND Cancer-associated fibroblasts (CAFs) are functionally and structurally essential for tumor progression. There are 3 main origins of CAFs: mesenchymal stem cells (MSCs), epithelial-to-mesenchymal (EMT) transition cells, and tissue-resident cells. Pericytes retain characteristics of progenitor cells and can differentiate into other cells under normal physiological conditions and into myofibroblasts under pathological conditions. Exosomes play an important role in intercellular communication by transferring membrane components and nucleic acids between different cells...
April 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29667024/double-baltazar-procedure-for-repair-of-gastric-leakage-post-sleeve-gastrectomy-from-two-sites-case-report-of-new-surgical-technique
#4
Hussein Mcheimeche, Samer H Dbouk, Riad Saheli, Dany Lichaa, Louai S Chalaby
BACKGROUND: Staple line leak is one of the most challenging complications following laparoscopic sleeve gastrectomy, with a rate reaching near 1%. Its management often implicates a multidisciplinary approach and experienced bariatric and metabolic surgeons. The literature is abundant on various approaches to treat single staple line leak with variable results. But what to do in front of an intra-op incidental finding of double gastric fistulae? METHODS: In this article, we describe a new successful surgical treatment option of double Baltazar technique for a patient who was found to have two gastric fistulae post-sleeve gastrectomy...
April 18, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29666402/expression-of-kk-lc-1-a-cancer-testis-antigen-at-non-tumour-sites-of-the-stomach-carrying-a-tumour
#5
Takashi Fukuyama, Nobue Futawatari, Rui Yamamura, Taiga Yamazaki, Yoshinobu Ichiki, Akira Ema, Hideki Ushiku, Yatsushi Nishi, Yoshihito Takahashi, Toshikazu Otsuka, Hitoshi Yamazaki, Wasaburo Koizumi, Kosei Yasumoto, Noritada Kobayashi
Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression at non-tumour sites and the clinical utility of these phenomena...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663561/concise-machinery-for-monitoring-ubiquitination-activities-using-novel-artificial-ring-fingers
#6
REVIEW
Kazuhide Miyamoto, Kazuki Saito
Protein ubiquitination is involved in many cellular processes, such as protein degradation, DNA repair, and signal transduction pathways. Ubiquitin-conjugating (E2) enzymes of the ubiquitination pathway are associated with various cancers, such as leukemia, lung cancer, and gastric cancer. However, to date, detection of E2 activities is not practicable for capturing the pathological conditions of cancers due to complications related to the enzymatic cascade reaction. To overcome this hurdle, we have recently investigated a novel strategy for measuring E2 activities...
April 16, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29662080/involvement-of-amp-activated-protein-kinase-ampk-in-regulation-of-cell-membrane-potential-in-a-gastric-cancer-cell-line
#7
Lin Zhu, Xiao-Jian Yu, Sheng Xing, Feng Jin, Wei-Jun Yang
Membrane potential (Vmem ) is a key bioelectric property of non-excitable cells that plays important roles in regulating cell proliferation. However, the regulation of Vmem itself remains largely unexplored. We found that, under nutrient starvation, during which cell division is inhibited, MKN45 gastric cancer cells were in a hyperpolarized state associated with a high intracellular chloride concentration. AMP-activated protein kinase (AMPK) activity increased, and expression of cystic fibrosis transmembrane conductance regulator (CFTR) decreased, in nutrient-starved cells...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660255/trans-life-cycle-acclimation-to-experimental-ocean-acidification-affects-gastric-ph-homeostasis-and-larval-recruitment-in-the-sea-star-asterias-rubens
#8
Marian Y Hu, Etienne Lein, Markus Bleich, Frank Melzner, Meike Stumpp
AIM: Experimental simulation of near-future ocean acidification (OA) has been demonstrated to affect growth and development of echinoderm larval stages through energy allocation towards ion and pH compensatory processes. To date, it remains largely unknown how major pH regulatory systems and their energetics are affected by trans-generational exposure to near-future acidification levels. METHODS: Here we used the common sea star Asterias rubens in a reciprocal transplant experiment comprising different combinations of OA scenarios, in order to study trans-generational plasticity using morphological and physiological endpoints...
April 16, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29658052/reduced-%C3%AE-glcnac-glycosylation-on-gastric-gland-mucin-is-a-biomarker-of-malignant-potential-for-gastric-cancer-barrett-s-adenocarcinoma-and-pancreatic-cancer
#9
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
April 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29658029/in-vitro-lipid-digestion-in-raw-and-roasted-hazelnut-particles-and-oil-bodies
#10
Edoardo Capuano, Nicoletta Pellegrini, Eleni Ntone, Constantinos V Nikiforidis
Previous studies have proved that the physical encapsulation of nutrients by the cell walls of plant foods modulates macronutrient bioaccessibility during human digestion. In this study, we investigated structural factors that modulate lipid hydrolysis during in vitro digestion of raw and roasted hazelnut particles and isolated oil bodies. Isolated oil bodies exhibited a significantly higher lipid hydrolysis compared to hazelnut particles. Moreover, roasting had an impact on the structure of hazelnut cell walls implying a more efficient diffusion of digestive fluids and enzymes into the hazelnut cells...
April 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29657611/gastric-cancer-with-situs-inversus-totalis-does-it-really-create-difficulties-for-surgeons
#11
Ebubekir Gündeş, Durmuş Ali Çetin, Ulaş Aday, Hüseyin Çiyiltepe, Emre Bozdağ, Aziz Serkan Senger, Selçuk Gülmez, Kamuran Cumhur Değer, Orhan Uzun, Erdal Polat
Introduction: Situs inversus totalis (SIT) is a very rare condition that is seen at a rate of one in about 6000-8000 births. Aim: To offer a general view on the coexistence of SIT and gastric cancer, accompanied by a literature review. Material and methods: Within the scope of this study, the case of a patient with gastric adenocarcinoma and SIT has been presented. Previous research on gastric cancer cases with SIT was reviewed through a comprehensive search of the PubMed, Medline, and Google Scholar databases...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29652031/association-between-patient-characteristics-and-magnetically-controlled-capsule-endoscopy-findings
#12
Huasheng Lai, Junsheng Huang, Yangzhi Xu, Jie Zhang, Zhenyu Chen, Fengcheng Xi, Aimin Li, Side Liu
Background/Aim: Magnetically-controlled capsule endoscopy (MCE) is a potential option for the evaluation of gastric diseases in cases that are unsuited for conventional endoscopy, avoiding discomfort, sedation, and related complications. This retrospective study investigated associations between MCE findings and patient gender, age, and inpatient/outpatient status. Patients and Methods: The data of 580 consecutive patients who underwent MCE from 2015 to 2016 were analyzed...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29650885/-fentanyl-citrate-sublingual-tablets-were-effective-in-relieving-symptoms-of-akathisia-a-case-report
#13
Takaomi Kessoku, Akihiko Kusakabe, Tetsuya Matsuura, Yasushi Honda, Asuka Yoshimi, Ayumu Goto, Haruhisa Yoshida, Akiko Sukegawa, Chiaki Hata, Yukie Saito, Yoko Miyashita, Ryoko Yashiro, Tomoya Komori, Sachiko Arai, Atsushi Nakajima, Yasushi Ichikawa
Akathisia is a condition wherein sitting calmly and quietly is impossible, with a representative complaint of restless legs. It is generally assumed to be caused by anti-dopamine activity. In severe cases, it has been known to result in suicide attempt. We reported a case of drug-induced akathisia with difficulty in oral intake, in which fentanyl citrate sublingual tablets were found to be effective in relieving symptoms. The patient was a female aged 50's who had a gastric cancer with peritoneal dissemination causing pain and vomiting...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650840/-a-case-of-effective-palliative-care-with-cart-for-refractory-ascites-associated-with-cancerous-peritonitis-of-gastric-cancer
#14
Junji Kawada, Masaya Nishino, Tomoki Hata, Takayuki Ogino, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Yongkook Kim, Masaki Okuyama, Toshimasa Tsujinaka
Refractory ascites associated with cancerous peritonitis causes abdominal tension and reduced oral intake. Frequent ascites drainage can cause rapid worsening ofa patient's general condition. Cell-free and concentrated ascites reinfusion therapy (CART)for refractory ascites was first covered in 1981, and the general conditions ofpatients and their symptoms could be improved after undergoing CART. Herein, we report a case of effective palliative care with CART for refractory ascites associated with cancerous peritonitis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650837/-laparoscopic-distal-gastrectomy-for-elderly-patients-with-advanced-gastric-cancer-and-gastric-outlet-obstruction-a-case-report
#15
Kurumi Tsuchihashi, Ken Yuu, Satoshi Okumura, Sho Toyoda, Hiroshi Yasuda, Kansuke Yamamoto, Aya Ito, Naoto Mizumura, Hiroshi Tsuchihashi, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
A 90-year-old female patient was admitted to our hospital with a chief complaint of vomiting.Gastroscopy revealed type 3 gastric cancer and gastric outlet obstruction(GOO).Abdominal computed tomography revealed thickening of the antral wall and suggested the presence of 3 perigastric lymph node metastases, but there was no ascitic fluid or distant metastasis.The clinical diagnosis was T4a(SE)N2H0CYXP0M0, Stage III B, according to the Japanese Classification of Gastric Carcinoma.Her general conditions including kidney and cardiac function were good, we considered that she was able to tolerate radical distal gastrectomy...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649518/design-and-optimization-of-gastro-floating-sustained-release-tablet-of-pregabalin-in-vitro-and-in-vivo-evaluation
#16
Chao Qin, Mengmeng Wu, Siyuan Xu, Xiaowei Wang, Wenxing Shi, Yangyu Dong, Lei Yang, Wei He, Xiaopeng Han, Lifang Yin
Pregabalin is a promising drug for the treatment of neuropathic pain, a chronic disease affecting a large population needing long-term treatment. However, due to its short half-life, the commercial tablet has to be administered 2 to 3 times per day, with inconvenience for patient and fluctuations of plasma concentration. In this study, a gastro-floating drug delivery system of pregabalin was developed to prolong the gastric retention of drugs absorbed or act in stomach or upper gastrointestinal tract. First of all, it was proved that the drug was mainly absorbed in stomach and upper gastrointestinal tract...
April 9, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29644801/exosomal-micrornas-in-milk-from-mothers-delivering-preterm-infants-survive-in-vitro-digestion-and-are-taken-up-by-human-intestinal-cells
#17
Sarah Kahn, Yalin Liao, Xiaogu Du, Wei Xu, Jie Li, Bo Lönnerdal
SCOPE: This study investigates the ability of preterm milk exosomes to survive gastric/pancreatic digestion, internalization by intestinal epithelia, and the microRNAs (miRNAs) contents. METHODS AND RESULTS: At average infant age 1 week 6 days, milk was collected from mothers who delivered preterm and term infants (n  =  10). Milk was exposed to conditions simulating infant gut digestion. Exosomes were isolated and lysed, and the exposed miRNAs were sequenced...
April 12, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29629688/potential-latitudinal-variation-in-orodigestive-tract-cancers-in-africa
#18
H A Adeola, A O Adefuye, S A Jimoh
BACKGROUND: Previous studies have alluded to a causal relationship between pathological entities and geographical variations, but there is a paucity of studies from Africa discussing the effect of latitudinal variation on orodigestive cancers in this region. It seems plausible that the burden of orodigestive cancer would differ as a result of variations in diet, cultural habits, climate and environmental conditions down the length of Africa. OBJECTIVES: To analyse regional variations in prevalence, incidence and mortality data in the global cancer statistics database (GLOBOCAN 2012) curated by the World Health Organization and the International Agency for Research on Cancer...
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29625905/myogenic-oxidative-imbalance-interferes-with-antral-motility-in-obese-subjects
#19
Annunziata Scirocco, Lucia Pallotta, Marco Rengo, Antonia Ignazzi, Marilia Carabotti, Alessia Cicenia, Rosa Vona, Piero Chirletti, Maria Antonietta Maselli, Rossella Donghia, Mariagrazia Coluzzi, Paola Matarrese, Gianfranco Silecchia, Carola Severi
BACKGROUND: Obesity is characterized by a systemic low-grade chronic inflammatory oxidative condition that affects vascular and cardiac smooth muscle relaxation. In human antrum, relaxation is mediated by vasoactive intestinal peptide (VIP) through cAMP and cGMP signaling pathways. A genome-wide association study has demonstrated an association between VIP and obesity. AIM: To evaluate smooth muscle activity in human obese antrum, both in in vitro preparations as well as in vivo...
March 14, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29616362/association-between-aldh2-and-adh1b-polymorphisms-alcohol-drinking-and-gastric-cancer-a-replication-and-mediation-analysis
#20
Kuka Ishioka, Hiroyuki Masaoka, Hidemi Ito, Isao Oze, Seiji Ito, Masahiro Tajika, Yasuhiro Shimizu, Yasumasa Niwa, Shigeo Nakamura, Keitaro Matsuo
BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2; rs671, Glu504Lys) and alcohol dehydrogenase 1B (ADH1B; rs1229984, His47Arg) polymorphisms have a strong impact on carcinogenic acetaldehyde accumulation after alcohol drinking. To date, however, evidence for a significant ALDH2-alcohol drinking interaction and a mediation effect of ALDH2/ADH1B through alcohol drinking on gastric cancer have remained unclear. We conducted two case-control studies to validate the interaction and to estimate the mediation effect on gastric cancer...
April 3, 2018: Gastric Cancer
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