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Gastric conditioning

Marinko Marušić, Antonio Klemenčić, Rosana Troskot Perić, Goran Hauser
Gastroesophageal variceal hemorrhage is the most important clinical event that results from portal hypertension. It is a lifethreatening condition that demands rapid and efficient treatment. The first step in bleeding control is hemodynamic stabilization and pharmacological treatment, which includes administration of vasoactive drugs and short-term antibiotic prophylaxis. After initial hemodynamic stabilization, endoscopic therapy should be performed. The first choice of endoscopic treatment for esophageal bleeding is endoscopic variceal ligation (EVL), or endoscopic injection sclerotherapy (EIS) if EVL cannot be performed...
April 2018: Acta Gastro-enterologica Belgica
Jürgen Weinreich, Florian Struller, Iaroslav Sautkin, Shalva Giuashvili, Marc Reymond, Alfred Königsrainer, Timm C Schott
We performed an in-vitro study testing the chemosensitivity of peritoneal cancer cell lines (SW620, HCT116, MKN45, 23,132/87, OAW42) to various cytostatic drug regimens. A duplex drug, characterized by reversible linking of the antimetabolites 2'-deoxy-5-fluorouridine (5-FdU) and 3'-C-ethynylcytidine (ECyd), was compared to oxaliplatin or to cisplatin plus doxorubicin. The experiments were designed to reflect the conditions of intraperitoneal chemotherapy. CASY® (Cell Analysis System) technology was used to compare the impact of incubation temperature/duration and drug concentration on the viability of the cancer cell lines versus normal human dermal fibroblasts...
July 18, 2018: Investigational New Drugs
Toshitaka Morishima, Yoshifumi Matsumoto, Nobuyuki Koeda, Hiroko Shimada, Tsutomu Maruhama, Daisaku Matsuki, Kayo Nakata, Yuri Ito, Takahiro Tabuchi, Isao Miyashiro
BACKGROUND: The presence of comorbidities in cancer patients may influence treatment decisions and prognoses. This study aimed to examine the impact of comorbidities on overall survival in Japanese patients diagnosed with major solid tumors. METHODS: To obtain patient-level information on clinical conditions and vital status, we performed a record linkage of population-based cancer registry data from Osaka Prefecture, Japan and administrative data produced under the Diagnosis Procedure Combination (DPC) system...
July 14, 2018: Journal of Epidemiology
Zhu-Yue Chen, Ying-Ying Hu, Xiao-Fan Hu, Long-Xian Cheng
Recently, multipotent mesenchymal stromal cell (MSC) treatment has attracted special attention as a new alternative strategy for stimulating regeneration. Irradiation myocardial fibrosis (IMF) is a major complication associated with total body irradiation for hematopoietic stem cell transplantation, nuclear accidents, and thoracic radiotherapy for lung cancer, esophageal cancer, proximal gastric cancer, breast cancer, thymoma, and lymphoma. The aim of the present study was to assess the therapeutic paracrine effects of human umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in the cell model of IMF...
July 12, 2018: Journal of Radiation Research
Qingling Wang, Yangyang Tang, Tianyuan Wang, Hong-Li Yang, Xinyue Wang, Hongru Ma, Peng Zhang
The endothelial cell protein C receptor (EPCR) serves a key role in activated protein C (APC)-mediated cytoprotective effects in endothelial cells, and is involved in the development of certain types of human cancer. To the best of our knowledge, the present study is the first to demonstrate that EPCR may exert effects on gastric cancer angiogenesis in vitro . To detect microvessel density (MVD), the microvascular endothelial cells were stained for cluster of differentiation (CD)31 and CD34 in 61 cases of surgical resection of gastric carcinoma tissues, and the association between the expression of EPCR protein and MVD was analyzed...
August 2018: Oncology Letters
Xue-Sen Fang, Mo-Han Zhang, Jun-Yu Guo, Zheng Jin
The purpose of the study was to observe changes in endoplasmic reticulum stress (ERS)- and autophagy-related proteins in gastric smooth muscle tissues of diabetic rats with gastroparesis, investigate the effect of insulin-like growth factor 1 (IGF-1) on ERS and autophagy in rat gastric smooth muscle cells cultured under different glucose concentrations, and explore the influence of IGF-1 on development of diabetic gastroparesis (DGP). After establishing a rat model of DGP, rats were divided into normal control (NC) and 6-week diabetic model (DM6W) groups...
July 14, 2018: Molecular and Cellular Biochemistry
Vishal Yajnik, Kathryn M Breslin, Christa Riley
There have been many advances in the management of acute respiratory distress syndrome, a condition which Bellani et al, in the LUNG SAFE trial (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure), found represents up to 10.4% of intensive care unit admissions and 23.4% of patients requiring mechanical ventilation, with an unadjusted intensive care unit and hospital mortality of 35.3% and 40%, respectively. Studies have shown that prone positioning can improve oxygenation in patients who are mechanically ventilated for acute respiratory distress syndrome...
July 12, 2018: A&A practice
Honghu Xie, Qicheng Lu, Haitao Wang, Xianbo Zhu, Zhong Guan
PURPOSE: To explore the therapeutic effect of probiotics combined with enteral nutrition (ΕΝ) in postoperative patients with gastric cancer (GC). METHODS: 140 GC patients were enrolled in this study and randomly assigned into the test group and the control group, with 70 patients in each group. Patients in the test group were treated with probiotics combined with ΕΝ, while those in the control group were treated with common ΕΝ. Patients' conditions were observed for 8 days...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Haige Huang, Jun Tian, Xin Xu, Qiong Liang, Xusen Huang, Jiaming Lu, Yongliang Yao
PURPOSE: To observe the infection rates of Helicobacter pylori (HP) in bile reflux gastritis (BRG) and gastric cancer and the clinical significance of HP eradication in BRG and gastric cancer patients complicated with HP. METHODS: 248 patients diagnosed with BRG and gastric cancer via gastroscopy were enrolled in this study. HP detection and infection rates of HP were evaluated. Then, BRG and gastric cancer patients complicated with HP were randomly divided into BRG group 1, BRG group 2, gastric cancer group 1 and gastric cancer group 2...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
H Mackenzie, S R Markar, A Askari, O Faiz, M Hull, S Purkayastha, H Møller, J Lagergren
BACKGROUND: Obesity increases the risk of several types of cancer. Whether bariatric surgery influences the risk of obesity-related cancer is not clear. This study aimed to uncover the risk of hormone-related (breast, endometrial and prostate), colorectal and oesophageal cancers following obesity surgery. METHODS: This national population-based cohort study used data from the Hospital Episode Statistics database in England collected between 1997 and 2012. Propensity matching on sex, age, co-morbidity and duration of follow-up was used to compare cancer risk among obese individuals undergoing bariatric surgery (gastric bypass, gastric banding or sleeve gastrectomy) and obese individuals not undergoing such surgery...
July 13, 2018: British Journal of Surgery
Chadin Tharavej, Worawit Kattipatanapong, Suppaut Pungpapong, Suthep Udomsawaengsup, Krit Kitisin, Patpong Navicharern
BACKGROUND: Early postoperative jejunal limb obstruction is a rare complication following gastric surgery with jejunal reconstruction. The condition is mainly attributed to kinking of the jejunal limbs, gastrojejunal or jejunojejunal anastomosis. There has been currently limited information regarding the safety and efficacy of endoscopic treatment in patients with early postoperative jejunal obstruction. We aimed to investigate outcome of endoscopic small-bore naso-jejunal (N-J) tube stenting across the obstructed segment in patients with uncomplicated early postoperative partial jejunal limb obstruction...
July 12, 2018: Surgical Endoscopy
Martin Stašek, René Aujeský, Radek Vrba, Martin Loveček, Josef Chudáček, Petr Janda, Michal Gregořík, Katherine Vomáčková, Čestmír Neoral, Dušan Klos
Introduction: Intraoperative esophagogastroduodenoscopy (IOG) is a diagnostic and therapeutic method for a variety of special conditions in upper gastrointestinal (UGI) pathology. The indication remains individual due to insufficient evidence and limited training of surgeons in digestive endoscopy. Aim: To evaluate the indications, benefits and risks of IOG. Material and methods: A single-center retrospective study of 110 consecutive IOGs in 104 patients was performed...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Thennakoon M Sampath Udeni Gunathilake, Yern Chee Ching, Cheng Hock Chuah, Hazlee Azil Illias, Kuan Yong Ching, Ramesh Singh, Liou Nai-Shang
Nanocellulose reinforced chitosan hydrogel was synthesized using chemical crosslinking method for the delivery of curcumin which is a poorly water-soluble drug. Curcumin extracted from the dried rhizomes of Curcuma longa was incorporated to the hydrogel via in situ loading method. A nonionic surfactant (Tween 20) was incorporated into the hydrogel to improve the solubility of curcumin. After the gas foaming process, hydrogel showed large interconnected pore structures. The release studies in gastric medium showed that the cumulative release of curcumin increased from 0...
July 2, 2018: International Journal of Biological Macromolecules
Wolfgang Fischbach, Peter Malfertheiner
BACKGROUND: Infection with Helicobacter pylori (H. pylori) is a major pathogenic factor for gastroduodenal ulcer disease and gastric carcinoma, as well as for other types of gastric and extragastric disease. As a result of changing epidemiologic conditions (e.g., immigration), changing resistance patterns with therapeutic implications, and new knowledge relating to the indications for pathogen eradication, the medical management of H. pylori is a dynamic process in need of periodic reassessment...
June 22, 2018: Deutsches Ärzteblatt International
Florencia Neffa, Lucia Garcia, Adriana Della Valle, Florencia Carusso, Carolina Vergara, Daniel Sanchez, Marta Sapone, Noelia Silveyra, Ana Laura Revello, Patricia Esperon
Familial adenomatous polyposis (FAP) is an autosomal dominant genetic condition, caused by mutations in the adenomatous polyposis coli ( APC ) tumor suppressor gene. Desmoid tumors (DTs) are seen in 15% to 20% of FAP patients. Specific location of mutation serves as a guide to predict colonic and extra colonic manifestations and their aggressiveness. A severe FAP-phenotypic family was registered in a genetic counselling high-risk Uruguayan hereditary cancer clinic. Proband's DNA was analysed by NGS, detecting a pathogenic mutation in APC gene...
June 2018: Journal of Gastrointestinal Oncology
Elena Romano, Megi Vllahu, Valentina Bizzarro, Raffaella Belvedere, Roberta Esposito, Antonello Petrella, Alessandra Tosco
Trefoil factor 1 (TFF1) is a small secreted protein expressed in the gastrointestinal tract where, together with the other two members of its family, it plays an essential role in mucosal protection and repair against injury. The molecular mechanisms involved in the protective function of all three TFF proteins are not fully elucidated. In this paper, we investigated the role of TFF1 in epithelial to mesenchymal transition (EMT) events. The effects of TFF1 on cellular models in normoxia and/or hypoxia were evaluated by western blot, immunofluorescence, qRT-PCR and trans-well invasion assays...
July 11, 2018: International Journal of Molecular Sciences
Lauren N Moomjian, Ryan D Clayton, Laura R Carucci
A variety of entities may mimic drainable abscesses. This can lead to misdiagnosis of these entities, unnecessary percutaneous placement of a pigtail drainage catheter, other complications, and delay in appropriate treatment of the patient. Types of entities that may mimic drainable abscesses include neoplasms (lymphoma, gallbladder cancer, gastrointestinal stromal tumor, ovarian cancer, mesenteric fibromatosis, ruptured mature cystic teratoma, recurrent malignancy in a surgical bed), ischemia/infarction (liquefactive infarction of the spleen, infarcted splenule), diverticula (calyceal, Meckel, and giant colonic diverticula), and congenital variants (obstructed duplicated collecting system)...
July 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Suseela Somarajan, Nicole Muszynski, Dilovan Hawrami, Joseph D Olson, Leo K Cheng, Leonard Alan Bradshaw
OBJECTIVE: The prokinetic action of erythromycin is clinically useful in conditions associated with gastrointestinal hypomotility. Although erythromycin is known to affect the electrogastrogram, no studies have examined the effects that erythromycin has on gastric slow wave magnetic fields. METHODS: In this study, gastric slow wave activity was assessed simultaneously using non-invasive magnetogastrogram, electrogastrogram, and mucosal electromyogram recordings...
May 17, 2018: IEEE Transactions on Bio-medical Engineering
Pengfei Wang, Naiyi Yin, Xiaolin Cai, Huili Du, Zejiao Li, Guoxin Sun, Yanshan Cui
Arsenic (As) is a highly toxic contaminant in food and soil. In this study, we investigated the effects of four nutritional states (including a fed state with vitamin C, a fed state with protein powder, a fed state with glucose and a fasted state) on the variability of soil As bioaccessibility and biotransformation using the physiologically based extraction test (PBET) combined with a simulator of the human intestinal microbial ecosystem model (SHIME). The results indicated that the vitamin C and protein powder increased As bioaccessibility in gastric digests...
July 7, 2018: Science of the Total Environment
Marta Tsirigotis-Maniecka, Lilianna Szyk-Warszyńska, Aneta Michna, Piotr Warszyński, Kazimiera A Wilk
This work reports the development of different types of alginate hydrogel microparticles designed specifically for the esculin (ESC) payload. Negatively charged alginate (ALG) microspheres were prepared by the ionotropic gelation technique, and an oppositely charged polyelectrolyte (PE) shell as a compatible polycation (chitosan (CHIT) or gelatin (GEL)) or a synthetic PEs (poly(allylamine hydrochloride) (PAH) and poly(4-styrenesulfonate) (PSS)) were adsorbed using electrostatic complexation. Thorough characterization of microparticles was performed with advanced microscopic techniques (scanning electron, fluorescence and confocal), followed by stability studies, ESC encapsulation efficacy determination and in vitro release kinetics measurements...
July 3, 2018: Journal of Colloid and Interface Science
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