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Gastric conditioning

Xueqiang Yan, Houfang Kuang, Zhenchuang Zhu, Haibin Wang, Jun Yang, Xufei Duan, Hongqiang Bian, Nannan Zheng, Xuyong Chen
OBJECTIVE: The aim of this study was to investigate the pathogenesis, symptoms and individualized surgical management in pediatrics with gastroduodenal perforation (GDP). METHODS: Patients diagnosed with GDP from January 2013 to December 2016 in our hospital were collected and divided into gastric perforation (GP) group and duodenal perforation (DP) group. Demographics, clinical events, etiological factors, symptoms, the time from symptom onset to operation, intraoperative findings and surgical procedures were analyzed...
November 17, 2018: Pediatric Surgery International
Chikako Murakami, Wataru Irie, Chizuko Sasaki, Naomi Nakamaru, Momoko Sakamoto, Junpei Nagato, Fumiko Satoh
We report a case of sudden death in a patient who developed extensive gastric necrosis secondary to acute gastric dilatation. A 36-year-old man with mental retardation (but without difficulties in activities of daily living), developed an illness after a meal out with friends, necessitating 3 hospital visits. He returned home after receiving drug therapy; however, his condition deteriorated, and he was transferred to our hospital via ambulance. Whole-body computed tomography performed upon admission revealed gastric dilatation...
November 13, 2018: Legal Medicine
Shivani Jamwal, Bhagat Ram, Sunita Ranote, Rohini Dharela, Ghanshyam S Chauhan
Designing strategies for the use of biopolymer-based nanoparticles as drug delivery carriers is a considerable challenge in pharmaceutical science. Present study reports synthesis of a novel glucose responsive and in-vitro pH triggered insulin delivery system comprised of glucose oxidase immobilized on acryloyl crosslinked dextran dialdehyde (ACDD) nanoparticles. Scanning electron microscopy, transmission electron microscopy and particle size analysis data revealed that these carriers possess nanosize which is an important parameter for drug delivery applications...
November 15, 2018: International Journal of Biological Macromolecules
Malinda Lyon, Chris Bashian, Casey Sheck, Leon Kushnir, Gus J Slotman
BACKGROUND: Previously we have reported variation in pre-operative clinical characteristics between women and men undergoing laparoscopic roux-en-Y gastric bypass (LRYGB). However, variation by sex in post-operative outcomes following LRYGB has not been investigated. METHODS: Pre-operative data was compared to follow-up data at 12 months after surgery on 83,059 patients from the Surgical Review Corporation's BOLD database. Data included age, weight, BMI, and 31 obesity-related medical conditions...
November 9, 2018: American Journal of Surgery
Daria S Khramova, Fedor V Vityazev, Nikita Yu Saveliev, Andrey A Burkov, Vladislav S Beloserov, Ekaterina A Martinson, Sergey G Litvinets, Sergey V Popov
The rheological characteristics and transit time of gastric digesta and the postprandial glycaemic response in mice orally administered with water (control) or pectin solutions supplemented (AP-Ca) or not supplemented (AP) with CaCO3 were elucidated. AP and AP-Ca increased viscosity, storage and loss moduluses (G' and G'') of mice gastric digesta. The gelling capacity of AP-Ca in acidic gastric conditions appeared to provide a greater enhancement of gastric digesta viscosity compared with AP. The postprandial blood glucose concentration was lower in mice orally administered with AP or AP-Ca compared with control mice...
February 1, 2019: Carbohydrate Polymers
Liyuan Yun, Dezhi Li, Lu Yang, Min Zhang
The conditions of wheat germ polysaccharide extraction were determined using the water extraction method. The gastric and intestinal digestion of wheat germ polysaccharide was analyzed in vitro. According to a single factor experiment and response surface experiment, the optimal extraction conditions of wheat germ polysaccharide were the following: liquid-solid ratio, 5:1 mL/g; extraction temperature, 69 °C; repetition of the extracting procedure, 3 times; extraction time, 44 min. Under such conditions, wheat germ polysaccharide yield was 8...
November 13, 2018: International Journal of Biological Macromolecules
Elisa Zambaiti, Federico Scottoni, Eleonora Rizzi, Simone Russo, Koichi Deguchi, Simon Eaton, Alessandro F Pellegata, Paolo De Coppi
BACKGROUND: Conditions leading to reduced gastric volume are difficult to manage and are associated to poor quality-of-life. Stomach augmentation using a tissue-engineered stomach is a potential solution to restore adequate physiology and food reservoir. Aim of this study was to evaluate the decellularisation of whole rat stomach using a detergent-enzymatic protocol. METHODS: Stomachs harvested from rats were decellularised through luminal and vascular cannulation using 24-h detergent-enzymatic treatment and completely characterized by appropriate staining, DNA and Extracellular matrix -component quantifications...
November 16, 2018: Pediatric Surgery International
Č Neoral, R Aujeský, R Vrba, M Stašek
The authors present a review article evaluating the use of the colon as a replacement for the esophagus. We present current indications for both benign and malignant conditions and compare the advantages and disadvantages of the technical possibilities of esophageal reconstruction. The surgical technique utilizing the vascular bundle of the left colic artery and retrosternal location of the colonic conduit is discussed and documented in detail. Furthermore, we describe both early and late complications, including their management...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
Wahib Alrofati, Amir Javan-Khoshkholgh, Rui Bao, Qi Kang, Nadi Abu Mahfouz, Aydin Farajidavar
The purpose of this paper is to develop and validate a configurable system that can wirelessly acquire gastric electrical activity called slow waves, and deliver high energy electrical pulses to modulate its activity. The system is composed of a front-end unit, and an external stationary backend unit that is connected to a computer. The front-end unit contains a recording module with four channels, and a stimulating module with two channels. Commercial off-theshelf components were used to develop front- and back-end units...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Tali Shindler-Itskovitch, Gabriel Chodick, Varda Shalev, Khitam Muhsen
BACKGROUND: Helicobacter pylori causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of H pylori infection and peptic ulcer disease with stroke. METHODS: A cross-sectional study was undertaken using data of 147 936 individuals aged 25-95 years who underwent the urea breath test during 2002-2012, based on the computerized database of the second largest health maintenance organization in Israel...
November 15, 2018: Helicobacter
Kathleen L Lak, Melissa C Helm, Tammy L Kindel, Jon C Gould
INTRODUCTION/PURPOSE: Metabolic syndrome is commonly demonstrated in patients with morbid obesity undergoing bariatric surgery. The purpose of this study was to determine the effect of metabolic syndrome on morbidity and mortality following bariatric surgery. MATERIALS AND METHODS: The National Surgical Quality Improvement Program (NSQIP) dataset was queried for patients who underwent bariatric surgical procedures between 2012 and 2014. Patient demographics, comorbid conditions, bariatric procedure type, and postoperative complications were analyzed...
November 14, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Sunny Dhadlie, Daniel Mehanna, James McCourtney
INTRODUCTION: Pneumatosis Intestinalis (PI) can present with a broad range of presentations from chronic and non-specific to acute and life threatening. It is paradoxically one of the few conditions where a pneumoperitoneum found in the diagnostic workup is not necessarily an indication for laparotomy. PRESENTATION OF CASES: The first case is of a 75 year old gentlemen who attended the emergency department after several weeks of worsening abdominal pain and weight loss...
November 2, 2018: International Journal of Surgery Case Reports
Muhammad Afzaal, Farhan Saeed, Muhammad Umair Arshad, Muhammad Tahir Nadeem, Muhammad Saeed, Tabussam Tufail
The objective of this work was to explore the effect of two encapsulating polysaccharides (sodium alginate and carrageenan) on the viability of probiotic bacteria (L. acidophilus) in ice cream and under simulated gastrointestinal (GIT) conditions. For the purpose, probiotic cells were encapsulated in sodium alginate and carrageenan by an encapsulator using standard operating conditions. Ice cream was manufactured by adding free and microencapsulated probiotics. The survival of free and encapsulated probiotics was monitored over a period of 120 days at - 20 °C...
November 14, 2018: Probiotics and Antimicrobial Proteins
Cheryl Chia-Hui Chen, Yi-Ting Yang, I-Rue Lai, Been-Ren Lin, Ching-Yao Yang, John Huang, Yu-Wen Tien, Chiung-Nien Chen, Ming-Tsan Lin, Jin-Tung Liang, Hsiu-Ching Li, Guan-Hua Huang, Sharon K Inouye
OBJECTIVE: To evaluate the effects of the modified Hospital Elder Life Program (mHELP) comprising 3 nurse-administered protocols in older patients undergoing gastrointestinal (GI) surgery. DESIGN: Cluster randomized trial. SETTING: Two 36-bed GI wards at a university-affiliated medical center in Taiwan. PARTICIPANTS: Older patients (≥65 years, N = 377) were recruited if they were scheduled for elective GI surgery with an expected length of hospital stay >6 days...
November 10, 2018: Journal of the American Medical Directors Association
Elena A Günter, Oxana V Popeyko, Elena I Istomina
The aims of this research were to obtain modified pectins of callus cultures using various culture conditions, to evaluate the relationship between the chemical characteristics of pectins, the swelling behavior and the release of prednisolone from calcium pectinate gel (CaPG) beads. An increase of the calcium concentration in the culture media correlated significantly with the rhamnogalacturonan I (RG-I) branching of the pectin. The beads from the pectin with a higher RG-I branching had the lower prednisolone release in a gastric fluid...
November 10, 2018: Journal of Biotechnology
Atsushi Kambayashi, Jennifer Dressman
The aim of the current research was to develop an in silico oral absorption model coupled with an in vitro dissolution/precipitation testing to predict gastric pH-dependent drug-drug interactions for weakly basic drugs. The effects of elevated gastric pH on the plasma profiles of dipyridamole, prasugrel, and nelfinavir were simulated and compared with pharmacokinetic data reported in humans with or without use of proton pump inhibitors or histamine H2 receptor antagonists. The in vitro dissolution and precipitation data for the weakly basic drugs in biorelevant media were obtained using paddle apparatus...
November 10, 2018: Journal of Pharmaceutical Sciences
Andreas Kroh, Roman M Eickhoff, Daniel Heise, Patrick H Alizai, Karl P Rheinwalt, Ulf P Neumann, Florian T Ulmer
BACKGROUND: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this procedure remain largely unknown and are difficult to address in human studies. Here, we present a new physiologic mouse model for mechanistic and long-term investigations. METHODS: Six-week-old C57Bl/6 mice were fed a high-fat diet for 12 weeks and scheduled for OAGB or sham operation...
November 12, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Kirsteen N Browning, R Alberto Travagli
PURPOSE OF REVIEW: This review summarizes the organization and structure of vagal neurocircuits controlling the upper gastrointestinal tract, and more recent studies investigating their role in the regulation of gastric motility under physiological, as well as pathophysiological, conditions. RECENT FINDINGS: Vagal neurocircuits regulating gastric functions are highly plastic, and open to modulation by a variety of inputs, both peripheral and central. Recent research in the fields of obesity, development, stress, and neurological disorders highlight the importance of central inputs onto these brainstem neurocircuits in the regulation of gastric motility...
November 9, 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Paulo Paixão, Marival Bermejo, Bart Hens, Yasuhiro Tsume, Joseph Dickens, Kerby Shedden, Niloufar Salehi, Mark J Koenigsknecht, Jason R Baker, William L Hasler, Robert Lionberger, Jianghong Fan, Jeffrey Wysocki, Bo Wen, Allen Lee, Ann Frances, Gregory E Amidon, Alex Yu, Gail Benninghoff, Raimar Löbenberg, Arjang Talattof, Duxin Sun, Gordon L Amidon
Exploring the intraluminal behavior of an oral drug product in the human gastrointestinal (GI) tract remains challenging. Many in vivo techniques are available to investigate the impact of GI physiology on oral drug behavior in fasting state conditions. However, little is known about the intraluminal behavior of a drug in postprandial conditions. In a previous report, we described the mean solution and total concentrations of ibuprofen after oral administration of an immediate-release (IR) tablet in fed state conditions...
November 12, 2018: Molecular Pharmaceutics
Maryam Amiri Dehcheshmeh, Milad Fathi
In this study, encapsulation of aqueous saffron extract (ASE) was studied using a core-shell nanofiber structure (zein-tragacanth) via coaxial electrospinning technique. Morphological features of nanofibers were investigated under different processing conditions (polymer concentration and applied voltage). The nanofibers produced under optimum criteria had diameter in a range of 95 to 271 nm. Concentration of zein and percentage of ASE were found to be critical factors affecting loading capacity (LC) and encapsulation efficiency (EE)...
October 27, 2018: International Journal of Biological Macromolecules
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