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Lignocaine infusion

Siddarameshwar S Harsoor, Devika Rani, M N Roopa, S Lathashree, K Sudheesh, S S Nethra
BACKGROUND: Lidocaine and Dexmedetomidine are known to blunt the stress response to surgery, and have anesthetic sparing activity. This study was designed to evaluate and compare the anesthetic sparing effect of intravenous lidocaine with Dexmedetomidine infusion during sevoflurane based general anesthesia and also to assess their effects on hemodynamic parameters. METHODS: Forty-eight ASA I-II patients aged between 18-55 yr, scheduled for abdominal surgery lasting less than 2 h, performed under general anesthesia were enrolled and they were randomly allocated to Lidocaine(L), Dexmedetomidine (D) and Saline (S) groups of 16 each...
October 2015: Middle East Journal of Anesthesiology
P Hari Keerthy, Ramdas Balakrishna, Krishna Mohan Srungeri, Nikhil Singhvi, Joseph John, Mueedul Islam
OBJECTIVE: The objective of the study was to assess the efficacy of propofol and midazolam as an intravenous sedative agent in minor oral surgical procedures in terms of: (a) the onset of action, (b) heart rate, (c) oxygen saturation, (d) systolic and diastolic blood pressure, (e) respiratory rate, (f) pain during the injection of sedative agent, (g) recovery period, (h) side effects, (i) patient's cooperation during the surgery. METHODOLOGY: This was a double blind randomized study in which one group of 20 patients received propofol with the induction dose of 0...
September 2015: Journal of Maxillofacial and Oral Surgery
Shruti Jain, Rashid M Khan
BACKGROUND AND AIMS: Lignocaine in intravenous (IV) bolus dose has been used for minimising haemodynamic changes associated with intubation and extubation. Furthermore, IV infusion has been used for post-operative analgesia. We investigated whether IV peri-operative lignocaine (bolus and infusion) would be able to produce both the effects simultaneously in elective laparoscopic cholecystectomies. METHODS: In this randomised prospective study, 60 patients undergoing elective laparoscopic cholecystectomy were randomly divided into two groups of 30 each...
June 2015: Indian Journal of Anaesthesia
Sunil Kumar Sinha, Bandi Joshiraj, Lalita Chaudhary, Nitin Hayaran, Manpreet Kaur, Aruna Jain
BACKGROUND AND AIMS: We designed a study to compare the effectiveness of dexmedetomidine plus ketamine combination with dexmedetomidine alone in search of an ideal sedation regime, which would achieve better intubating conditions, hemodynamic stability, and sedation for awake fiberoptic nasotracheal intubation. MATERIALS AND METHODS: A total of 60 adult patients of age group 18-60 years with American Society of Anesthesiologists I and II posted for elective surgery under general anesthesia were randomly divided into two groups of 30 each in this prospective randomized controlled double-blinded study...
October 2014: Journal of Anaesthesiology, Clinical Pharmacology
A Risberg, C Spadavecchia, B Ranheim, R Krontveit, H A Haga
Dexmedetomidine and lignocaine IV are used clinically to provide analgesia in horses. The aims of this study were to investigate the antinociceptive effects, plasma concentrations and sedative effects of 2, 4 and 6 µg/kg/h dexmedetomidine IV, with a bolus of 0.96 µg/kg preceding each continuous rate infusion (CRI), and 20, 40 and 60 µg/kg/min lignocaine IV, with a bolus of 550 µg/kg preceding each CRI, in 10 Swiss Warmblood horses. Electrically elicited nociceptive withdrawal reflexes were evaluated by deltoid muscle electromyography...
December 2014: Veterinary Journal
Parnandi Sridhar, Sarath Chandra Sistla, Sheik Manwar Ali, Vilvapathy Senguttuvan Karthikeyan, Ashok Shankar Badhe, Palghat Hariharan Ananthanarayanan
BACKGROUND: Perioperative stress response can be detrimental if excessive and prolonged. Intravenous (i.v.) lignocaine, while being an effective analgesic, has the added benefit of anti-inflammatory activity. This study was done to assess the effect of i.v. lignocaine on operative stress response and post-surgical ileus after elective open abdominal surgeries. METHODS: Patients (n = 134) were randomized into two groups (n = 67 each) to receive an i.v. infusion of lignocaine (group L) or saline (group S) as a bolus of 1...
June 2015: ANZ Journal of Surgery
Rui V Duarte, Jon H Raphael, Theodoros Dimitroulas, Elizabeth Sparkes, Jane L Southall, Robert L Ashford, George D Kitas
Osteoarthritis is the most common form of arthritis and includes manifestations of both nociceptive and neuropathic mechanisms. Intravenous lignocaine, a sodium channel blocker and neuronal membrane stabiliser, has been shown in controlled trials to be effective in neuropathic pain; however, the outcome of intravenous lignocaine in osteoarthritis patients has not been assessed yet. The existence of a neuropathic component to the pain of osteoarthritis was investigated by examining possible benefits upon sensory aspects of pain in osteoarthritis patients receiving intravenous lignocaine therapy...
March 2014: Rheumatology International
B Admani, F Essajee
Anaesthetic agents used locally can be toxic especially if given as an inappropriate dose or route. Lipid infusion has been demonstrated in several animal models to successfully resuscitate bupivacaine induced toxicity. We present a case of successful use of 26% lipid infusion to resuscitate a paediatric patient with a presumed subcutaneous injection of bupivacaine and lignocaine which led to neurological and cardiologic consequences.
August 2010: East African Medical Journal
Aziza Muhammad Hussain, Mansoor A Khan
Pain is experienced by people suffering from spinal cord injury leading to disability and affecting the person's functional ability, independence, psychological well - being, ability to return to work and quality of life. Pain management in these patients is notoriously difficult due to multiple factors and varied mechanism leading to pain. Only few treatments have been assessed in randomized, controlled trials and management is based on different case reports. We are reporting our experience of managing 2 patients with neuropathic pain following traumatic spinal cord injury...
April 2012: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
S Koirala, M Tripathi, A Subedi, B Bhattarai
This case report describes a successful fibreoptic naso-tracheal intubation in a patient with difficult airway due to a nearly head-size right parotid swelling. Nasal fibreoptic intubation was performed by maintaining spontaneous breathing under propofol infusion at a dose of 25 mcg/kg/hour and topical anaesthesia of vocal cords by using oxygen (6 l/min) flow to nebulize 4% lignocaine from the side port of the fibreoptic bronchoscope. The topical anaesthesia was achieved by keeping the scope in close proximity of the vocal cords and in the centre of view of the scope...
January 2011: JNMA; Journal of the Nepal Medical Association
S H Kim, E M Choi, C H Chang, H K Kim, M H Chung, Y R Choi
This study was designed to determine the optimal dose of remifentanil required for the successful insertion of Streamlined Liner of the Pharynx Airway (SLIPA) and to compare it to that required for laryngeal mask airway (LMA) insertion in patients receiving a propofol infusion at a standard effect-site concentration. Fifty-eight patients scheduled to undergo general anaesthesia were randomly assigned to either the SLIPA (n = 29) or LMA (n = 29) group. All patients were premedicated with midazolam 0.05 mg x kg(-1) and glycopyrrolate 0...
July 2011: Anaesthesia and Intensive Care
S M Carey, G Hocking
Brugada syndrome is characterised by specific electrocardiogram changes in the right precordial leads, a structurally normal heart and susceptibility to ventricular arrhythmias that may cause syncope or sudden death in otherwise fit young adults. Perioperative pharmacological and physiological changes may precipitate these events. Arrhythmias and symptoms typically occur at rest or sleep when vagal activity predominates. Although the condition is rare, the implications are serious and may result in death. Individual case reports describe diverse anaesthetic management...
July 2011: Anaesthesia and Intensive Care
Michael Wood
AIM: To add to the evidence base for safe and effective paediatric conscious sedation techniques in primary dental care. OBJECTIVE: To consider the safety and effectiveness of an alternative sedation technique for facilitating dental treatment in anxious children, thereby avoiding dental general anaesthetic. SETTING: Leagrave Dental Sedation Clinic. A primary care-based general and referral clinic for anxious patients, special care dentistry and oral surgery...
January 2011: SAAD Digest
B Pradhan
Objective of the study was to compare the effect of the drugs, intraoperative hemodynamic variables (heart rate, blood pressure) and associated complications (hypotension, nausea, shivering etc) between the bupivacaine and lignocaine group, when administered intrathecally in patients undergoing caesarean section. This is a randomized prospective study where the haemodynamic changes and the complications following sub arachnoid block either with 5.0% lignocaine or with 0.5% bupivacaine in 52 patients undergoing caeserian section were compared...
March 2010: Nepal Medical College Journal: NMCJ
B L Sng, L L Pay, A T H Sia
Low dose local anaesthetic and fentanyl epidural solutions are commonly 'topped-up' for urgent caesarean section. However, the block characteristics associated with newer local anaesthetics such as ropivacaine 0.75% and levobupivacaine 0.5% have not been fully determined. In a randomised double-blinded controlled clinical trial, we compared 2% lignocaine with adrenaline and fentanyl (LAF), 0.75% ropivacaine and 0.5% levobupivacaine for extension of low dose epidural analgesia for urgent caesarean section in 90 Asian parturients...
September 2008: Anaesthesia and Intensive Care
Max H Williams, Simon A Broadley
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) are considered to be rare primary headache disorders. The purpose of this study was to define the clinical features, response to prophylactic treatment and efficacy of lignocaine by subcutaneous infusion for periods of acute exacerbation requiring hospitalisation. Over a period of 6 years (March 2000--February 2006) all cases of SUNCT and SUNA in neurology clinics at the Gold Coast Hospital, Australia, were reviewed...
May 2008: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Ozlem Anbarci, Alparslan Apan, Saziye Sahin
Magnesium sulphate infusion decreases analgesic requirements after general anesthesia. Aim of this study was to assess the effects of postoperative magnesium infusion for 24 hours on duration of the block, sedation and postoperative analgesic consumption after brachial plexus block. After obtaining approval from local ethic committee, 70 ASA class I and II patients were included to the randomised double blind study. Brachial plexus block was performed using axillary approach with lignocaine 1.25% adrenaline 1/200 000 40 ml...
July 2007: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
Prabhat Kumar Sinha, Thomas Koshy, P Gayatri, V Smitha, Mathew Abraham, Ramesh Chandra Rathod
CONTEXT: Awake craniotomy is increasingly performed the world over. We share our experience of performing craniotomy awake with our anesthetic protocol. AIMS: To evaluate and analyze the anesthesia records of the patients who underwent awake craniotomy at our institution. SETTINGS AND DESIGN: University teaching hospital, Retrospective study. MATERIALS AND METHODS: We reviewed records of the 42 consecutive patients who underwent awake craniotomy under conscious sedation using Fentanyl and Propofol infusion until December 2005...
October 2007: Neurology India
J Ekberg, A Jayamanne, C W Vaughan, S Aslan, L Thomas, J Mould, R Drinkwater, M D Baker, B Abrahamsen, J N Wood, D J Adams, M J Christie, R J Lewis
The tetrodotoxin-resistant voltage-gated sodium channel (VGSC) Na(v)1.8 is expressed predominantly by damage-sensing primary afferent nerves and is important for the development and maintenance of persistent pain states. Here we demonstrate that muO-conotoxin MrVIB from Conus marmoreus displays substantial selectivity for Na(v)1.8 and inhibits pain behavior in models of persistent pain. In rat sensory neurons, submicromolar concentrations of MrVIB blocked tetrodotoxin-resistant current characteristic of Na(v)1...
November 7, 2006: Proceedings of the National Academy of Sciences of the United States of America
P R Scott, N D Sargison, C D Penny, R S Pirie
A 2% lignocaine solution infused at a dose of 2 mg/kg at the lumbosacral site gave excellent analgesia in 28 vasectomy operations and in 33 of 38 (87%) Caesarian operations at a dose of 4 mg/kg. Failure of the anesthetic technique in 4 sheep (6% of all operations) was associated with poor positioning of the ewe and incorrect identification of the epidural space. One fatality was recorded and was considered to result from lignocaine overdosage and the probable pooling of blood in the splanchnic vasculature. Pelvic limb paresis persisted for 2 to 4 h post epidural injection in all ewes, but no permanent paralysis was encountered...
October 1994: Theriogenology
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