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https://www.readbyqxmd.com/read/27628572/quantifying-the-association-between-physical-activity-and-cardiovascular-disease-and-diabetes-a-systematic-review-and-meta-analysis
#1
Ahad Wahid, Nishma Manek, Melanie Nichols, Paul Kelly, Charlie Foster, Premila Webster, Asha Kaur, Claire Friedemann Smith, Elizabeth Wilkins, Mike Rayner, Nia Roberts, Peter Scarborough
BACKGROUND: The relationships between physical activity (PA) and both cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) have predominantly been estimated using categorical measures of PA, masking the shape of the dose-response relationship. In this systematic review and meta-analysis, for the very first time we are able to derive a single continuous PA metric to compare the association between PA and CVD/T2DM, both before and after adjustment for a measure of body weight...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26947342/endovascular-therapy-including-thrombectomy-for-acute-ischemic-stroke-a-systematic-review-and-meta-analysis-with-trial-sequential-analysis
#2
Kevin Phan, Dong Fang Zhao, Steven Phan, Ya Ruth Huo, Ralph J Mobbs, Prashanth J Rao, Alex M Mortimer
One of the primary strategies for the management of acute ischemic stroke is intravenous (IV) thrombolysis with tissue plasminogen activator (t-PA). Over the past decade, endovascular therapies such as the use of stent retrievers to perform mechanical thrombectomy have been found to improve functional outcomes compared to t-PA alone. We aimed to reassess the functional outcomes and complications of IV thrombolysis with and without endovascular treatment for acute ischemic stroke using conventional meta-analysis and trial sequential analysis...
July 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/24631298/the-q223r-polymorphism-in-the-leptin-receptor-associates-with-objectively-measured-light-physical-activity-in-free-living-japanese
#3
Haruka Murakami, Motoyuki Iemitsu, Noriyuki Fuku, Kiyoshi Sanada, Yuko Gando, Ryoko Kawakami, Motohiko Miyachi
Physical activity (PA) is associated with reductions in the risk of all-cause mortality and in the prevalence of cardiovascular disease and stroke. Nevertheless, a large proportion of the general population may not be sufficiently active. PA level has been reported to be influenced by genetic factors, and we investigated whether Q223R polymorphism in the leptin receptor (LEPR) gene was associated with PA level. A total of 556 Japanese adults aged 24-65years old participated in this cross-sectional study. The duration and intensity of PA were objectively evaluated by triaxial accelerometry...
April 22, 2014: Physiology & Behavior
https://www.readbyqxmd.com/read/22931734/polymorphisms-of-genes-encoding-coagulation-factors-ii-v-vii-and-xiii-in-relation-to-pediatric-ischemic-stroke-family-based-and-case-control-study
#4
Ilona A Kopyta, Ewa Emich-Widera, Anna Balcerzyk, Pawel Niemiec, Iwona Zak, Ewa Pilarska, Marek Kaciński, Janusz Wendorff, Tomasz Nowak, Tomasz Iwanicki, Karolina Pienczk-Ręcławowicz, Katarzyna Pałatyńska
BACKGROUND: The investigation of a possible association between the FII, FV, FVII, and FXIII genes polymorphisms and pediatric ischemic stroke (IS). METHODS: The study group consisted of 392 individuals, including 81 children with IS, their biological parents (n=162), and 149 control children. The polymorphisms were genotyped using polymerase chain reaction-restriction fragments length polymorphism method. The relation between analyzed polymorphisms and the disease was tested by 2 independent methods: family-based association test-transmission/disequilibrium test (TDT) and classic case-control model...
September 2012: Neurologist
https://www.readbyqxmd.com/read/22470299/physical-activity-and-risk-of-cardiovascular-disease-a-meta-analysis-of-prospective-cohort-studies
#5
REVIEW
Jian Li, Johannes Siegrist
In order to update and improve available evidence on associations of physical activity (PA) with cardiovascular disease (CVD) by applying meta-analytic random effects modeling to data from prospective cohort studies, using high quality criteria of study selection, we searched the PubMed database from January 1980 to December 2010 for prospective cohort studies of PA and incident CVD, distinguishing occupational PA and leisure time PA, coronary heart disease (CHD) and stroke, respectively. Inclusion criteria were peer-reviewed English papers with original data, studies with large sample size (n ≥ 1,000) and substantial follow-up (≥ 5 years), available data on major confounders and on estimates of relative risk (RR) or hazard ratio (HR), with 95% confidence intervals (CI)...
February 2012: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/20929415/association-of-physical-activity-level-and-stroke-outcomes-in-men-and-women-a-meta-analysis
#6
REVIEW
Lien Diep, John Kwagyan, Joseph Kurantsin-Mills, Roger Weir, Annapurni Jayam-Trouth
OBJECTIVE: The protective effect of physical activity (PA) on risk of stroke remains controversial as a result of lack of insight into the sources of heterogeneity between studies. We performed a comprehensive meta-analysis of studies to (1) quantify the association between PA level and risk of stroke outcomes and (2) test the hypothesis that the association of PA level with stroke outcomes will be similar between men and women. The outcome measures are stroke incidence, stroke mortality, or both...
October 2010: Journal of Women's Health
https://www.readbyqxmd.com/read/19724234/relative-recirculation-a-fast-model-free-surrogate-for-the-measurement-of-blood-brain-barrier-permeability-and-the-prediction-of-hemorrhagic-transformation-in-acute-ischemic-stroke
#7
Shengping Wu, Rebecca E Thornhill, Shuo Chen, Wael Rammo, David J Mikulis, Andrea Kassner
OBJECTIVES: To retrospectively evaluate the prognostic performance of a dynamic susceptibility contrast (DSC) MRI metric for permeability (relative recirculation or rR) for the prediction of hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS). To compare rR with dynamic contrast-enhanced (DCE) MRI estimates of blood-brain barrier permeability (KPS). MATERIALS AND METHODS: Data obtained from 26 patients (age: 27-89 years) with a working diagnosis of AIS were examined retrospectively...
October 2009: Investigative Radiology
https://www.readbyqxmd.com/read/17929619/arterial-hypertension-myocardial-infarction-and-stroke-risk-of-development-and-psychosocial-factors
#8
V V Gafarov, H A Gromova, I V Gagulin, Y C Ekimova, D K Santrapinskiy
OBJECTIVE: To evaluate an influence of personal anxiety on risk of development of arterial hypertension (AH), myocardial infarction (MI) and stroke in men aged 25-64. STUDY DESIGN AND METHODS: Within the framework of program WHO MONICA-MOPSY a representative sample of men 25-64 years old (1984, 1988, 1994 years) was examined. The total sample was 2,149 persons. The period of supervision was 10-20 years. We counted as outcome all cases of AH, MI and stroke which had arisen for the first time...
2007: Alaska Medicine
https://www.readbyqxmd.com/read/17636680/withdrawn-primary-angioplasty-versus-intravenous-thrombolysis-for-acute-myocardial-infarction
#9
REVIEW
M Cucherat, E Bonnefoy, G Tremeau
BACKGROUND: Intravenous thrombolytic therapy is the standard care for patients with acute myocardial infarction, based upon its widespread availability and ability to reduce patient mortality well demonstrated in randomised trials. Despite its proven efficacy, thrombolytic therapy has limitations. Many patients are ineligible for treatment with thrombolytics. Of those given thrombolytic therapy, 10 to 15 percent have persistent occlusion or reocclusion of the infarct-related artery. Consequently, primary angioplasty (primary PTCA) has been advocated as a better treatment of myocardial infarction...
2003: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/16809570/the-alias-pilot-trial-a-dose-escalation-and-safety-study-of-albumin-therapy-for-acute-ischemic-stroke-ii-neurologic-outcome-and-efficacy-analysis
#10
Yuko Y Palesch, Michael D Hill, Karla J Ryckborst, Diego Tamariz, Myron D Ginsberg
BACKGROUND AND PURPOSE: High-dose human albumin (ALB) is robustly neuroprotective in rodent stroke models. A phase I dose-escalation study was conducted to assess the safety of ALB therapy in ischemic stroke. We analyzed the data for preliminary evidence of treatment efficacy. METHODS: Eighty-two subjects with acute ischemic stroke (NIH Stroke Scale [NIHSS] of 6 or above) received 25% ALB beginning within 16 hours of stroke onset. Six successive ALB dose tiers were assessed (range, 0...
August 2006: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/15840623/is-primary-angioplasty-more-effective-than-prehospital-fibrinolysis-in-diabetics-with-acute-myocardial-infarction-data-from-the-captim-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Eric Bonnefoy, Philippe Gabriel Steg, Sylvie Chabaud, Pierre-Yves Dubien, Frédéric Lapostolle, Frédéric Boudet, Jean-Michel Lacroute, Frederic Dissait, Gérald Vanzetto, Alain Leizorowicz, Paul Touboul
AIMS: The CAPTIM study randomized patients managed within 6 h of acute ST-segment elevation myocardial infarction to primary angioplasty or prehospital fibrinolysis (rt-PA), with immediate transfer to a centre with interventional facilities. It found a similar incidence of the primary endpoint of death, recurrent MI, or stroke at 30 days with both strategies. We report here the outcome in the diabetic subgroup. METHODS AND RESULTS: The relationship of diabetic status (diabetics, n=103, non-diabetics, n=731) and treatment strategy with the occurrence of the primary endpoint and of death was analysed...
September 2005: European Heart Journal
https://www.readbyqxmd.com/read/15165657/physical-activity-decreases-cardiovascular-disease-risk-in-women-review-and-meta-analysis
#12
REVIEW
Yuko Oguma, Tomoko Shinoda-Tagawa
OBJECTIVE: To review and quantify the dose-response relationship of physical activity (PA) in initially healthy women on cardiovascular disease (CVD) outcomes, especially coronary heart disease (CHD) and stroke, and to assess the minimum amount of PA to reduce CVD risk. DATA SOURCES: Studies on PA and CVD were searched in MEDLINE (January 1966-March 2003) with additional manual searches. DATA SELECTION: Studies were included if they (1) provided data on women; (2) assessed PA (exposure) as either a continuous variable or a categorical variable with three or more levels, and CVD (outcome); and (3) provided information on relative risks (RRs) and 95% confidence intervals...
June 2004: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/12917910/primary-angioplasty-versus-intravenous-thrombolysis-for-acute-myocardial-infarction
#13
REVIEW
M Cucherat, E Bonnefoy, G Tremeau
BACKGROUND: Intravenous thrombolytic therapy is the standard care for patients with acute myocardial infarction, based upon its widespread availability and ability to reduce patient mortality well demonstrated in randomised trials. Despite its proven efficacy, thrombolytic therapy has limitations. Many patients are ineligible for treatment with thrombolytics. Of those given thrombolytic therapy, 10 to 15 percent have persistent occlusion or reocclusion of the infarct-related artery. Consequently, primary angioplasty (primary PTCA) has been advocated as a better treatment of myocardial infarction...
2003: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/10796812/primary-angioplasty-versus-intravenous-thrombolysis-for-acute-myocardial-infarction
#14
REVIEW
M Cucherat, E Bonnefoy, G Tremeau
BACKGROUND: Intravenous thrombolytic therapy is the standard care for patients with acute myocardial infarction, based upon its widespread availability and ability to reduce patient mortality well demonstrated in randomised trials. Despite its proven efficacy, thrombolytic therapy has limitations. Many patients are ineligible for treatment with thrombolytics. Of those given thrombolytic therapy, 10 to 15 percent have persistent occlusion or reocclusion of the infarct-related artery. Consequently, primary angioplasty (primary PTCA) has been advocated as a better treatment of myocardial infarction...
2000: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/9531345/haemostatic-factors-and-prediction-of-ischaemic-heart-disease-and-stroke-in-claudicants
#15
F B Smith, A Rumley, A J Lee, G C Leng, F G Fowkes, G D Lowe
Thrombotic risk factors may be important in determining cardiovascular outcome in patients with symptomatic peripheral arterial disease. A cohort study with a 6-year follow-up period was established to determine the relationships between haemostatic and rheological factors and incident ischaemic heart disease (IHD) and stroke events in patients with peripheral arterial disease. A consecutive series of 607 patients with intermittent claudication was examined between 1989 and 1990 at the Peripheral Vascular Clinic, Royal Infirmary of Edinburgh...
March 1998: British Journal of Haematology
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