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https://www.readbyqxmd.com/read/29542810/inflammasome-activation-characterizes-lesional-skin-of-folliculitis-decalvans
#1
Alexia Eyraud, Brigitte Milpied, Denis Thiolat, Anne-Sophie Darrigade, Katia Boniface, Alain Taïeb, Julien Seneschal
Folliculitis decalvans (FD) is a chronic inflammatory disease leading to scarring alopecia with poorly defined pathogenesis. The aim of this study was to investigate the expression of markers associated with the activation of innate immune signals, such as inflammasome (NALP1 and NALP3), interleukin (IL)-1β and IL-8 and type I interferon (MxA). A retrospective monocentric study was conducted and included 17 patients with FD with available biopsies. Disease activity (stable vs. active) was defined clinically and histologically...
March 15, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29457012/impact-of-folliculitis-decalvans-on-quality-of-life-and-subjective-perception-of-disease
#2
Cristina Pindado-Ortega, David Saceda-Corralo, Laura Miguel-Gómez, Diego Buendía-Castaño, Pablo Fernández-González, Oscar M Moreno-Arrones, Pablo Fonda-Pascual, Adrian Alegre-Sánchez, Rita Rodrigues-Barata, Sergio Vañó-Galván
Folliculitis decalvans (FD) is a primary neutrophilic scarring alopecia characterized by perifollicular papules, crusts, and pustules frequently located on the vertex. FD may affect young men and women. Since it may lead to hair loss, it can have a negative impact on patients' quality of life. Nevertheless, studies have focused on clinical, prognostic, and therapeutic aspects without considering the psychological impact of FD. In our study, we found that FD patients experienced a considerable impact on their quality of life...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29341254/do-cutibacterium-acnes-and-staphylococcus-aureus-define-two-different-types-of-folliculitis-bacteriological-study-of-scalp-folliculitis
#3
LETTER
C Frenard, M-A Dagnelie, A Khammari, M Saint-Jean, A Boisrobert, S Corvec, B Dreno
No abstract text is available yet for this article.
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29341216/primary-scarring-alopecia-a-retrospective-study-of-89-patients-in-taiwan
#4
Hsing-Jou Su, An-Yu Cheng, Cheng-Han Liu, Chia-Bau Chu, Chaw-Ning Lee, Chao-Kai Hsu, Julia Yu-Yun Lee, Chao-Chun Yang
Primary scarring alopecia (PSA) is caused by irreversible damage to the hair epithelial stem cells that reside in hair follicles. There is limited published work regarding PSA amongst the Asian population. The aim of this study was to evaluate the clinical features and to characterize the subtypes of PSA in southern Taiwan. In this retrospective case series, we reviewed 89 patients with pathology-confirmed PSA. The data was collected from National Cheng Kung University Hospital between 1988 through 2016. The clinical and histological data were reviewed, and the patients were characterized into different subtypes of PSA based on the clinical features and histological findings...
January 16, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29313960/isotretinoin-treatment-for-folliculitis-decalvans-a-retrospective-case-series-study
#5
Berna Aksoy, Asli Hapa, Emine Mutlu
BACKGROUND: The literature includes only a few reports of oral isotretinoin for the treatment of folliculitis decalvans (FD). This study aimed to determine the most effective dose and duration of oral isotretinoin monotherapy for achieving remission in FD patients. METHODS: This retrospective case series study included FD patients that were treated with oral isotretinoin. Patient demographics, clinical characteristics, and treatment details were obtained from the patients' medical records...
February 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29204395/mutilating-keratoderma-with-concomitant-alopecia-and-keratoses-follicularis-spinulosa-decalvans-x-linked-olmsted-syndrome-and-its-response-to-isotretinoin
#6
Gunjan Verma, Kabir Sardana, R K Gautam
We report a case of mutilating keratoderma with alopecia and keratoses follicularis spinulosa decalvans (KFSD), which was initially diagnosed as ectodermal dysplasia and Olmsted syndrome but was revisited as a case of X-linked Olmsted (XLO) syndrome. We focus on this uncommon entity (XLO) to highlight the differentials of alopecia with palmoplantar keratoderma.
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29038892/-pityriasis-amiantacea-and-folliculitis-decalvans-an-unusual-manifestation-associated-with-antitumor-necrosis-factor-%C3%AE-therapy
#7
M Zamperetti, B Zelger, R Höpfl
We report on a 21-year-old woman with a 3-year history of crusts and erosions on her scalp that had appeared after starting treatment with adalimumab due to Crohn's disease. By clinicopathological correlation pityriasis amiantacea with underlying folliculitis decalvans was diagnosed. Topical and systemic antibiotic treatment showed rapid response. The occurrence of pityriasis amiantacea in folliculitis decalvans associated with tumor necrosis factor (TNF)-α inhibitor therapy is remarkable and highlights the ambivalent role of TNF-α in diseases with immunological dysfunctions in combination with infections...
December 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28940572/systemic-photodynamic-therapy-in-folliculitis-decalvans
#8
N J Collier, D Allan, F Diaz Pesantes, L Sheridan, E Allan
Folliculitis decalvans (FD) is classified as a primary neutrophilic cicatricial alopecia, and is estimated to account for approximately 10% of all cases of primary cicatricial alopecia. The role of dysfunctional immune activity and the presence of bacteria, particularly Staphylococcus aureus, appear pivotal. We describe a 26-year-old man with a 4-year history of FD that was recalcitrant to numerous systemic and topical therapies, whose disease was virtually cleared during a follow-up of 25 months following a course of treatment with systemic photodynamic therapy (PDT) using ultraviolet light (100-140 J/cm2 ) with porfimer sodium 1 mg/kg as monotherapy...
January 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28932072/trichoscopic-features-of-folliculitis-decalvans-results-in-58-patients
#9
Pablo Fernández-Crehuet, Sergio Vañó-Galván, Ana Maria Molina-Ruiz, Ana Rita Rodrigues-Barata, Cristina Serrano-Falcón, Antonio Martorell-Calatayud, Salvador Arias-Santiago, Didac Barco-Nebreda, Salvio Serrano, Pedro Jaén, Francisco M Camacho-Martínez
No abstract text is available yet for this article.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28932071/keratosis-follicularis-spinulosa-decalvans-with-associated-mental-retardation-response-to-isotretinoin
#10
Sarita Sanke, Vibhu Mendiratta, Archana Singh, Ram Chander
No abstract text is available yet for this article.
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28807321/folliculitis-decalvans-caused-by-bacterial-superinfection-secondary-to-erlotinib
#11
A Sahuquillo-Torralba, B Escutia-Muñoz, M Rodríguez-Serna, R Botella-Estrada
No abstract text is available yet for this article.
August 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28633753/tumor-necrosis-factor-induced-alopecia-alternative-pathology-and-therapy
#12
Jeremy Udkoff, Philip R Cohen
Tumor necrosis factor (TNF) inhibitors are used to treat Crohn disease and psoriasis. Although they are typically well tolerated, adverse effects include the development of alopecia, and paradoxically, psoriatic lesions. We recently described a woman with Crohn disease who developed alopecia and scalp psoriasis during infliximab therapy. After discontinuing infliximab and beginning oral and topical therapies, her alopecia completely resolved. We compared our experience with that of the Craddock et al. who described a woman with Crohn disease and alopecia secondary to adalimumab therapy...
June 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28442875/extreme-phenotype-of-epidermal-growth-factor-receptor-inhibitor-induced-destructive-folliculitis
#13
Florian Anzengruber, Barbara Meier, Julia-Tatjana Maul, Katrin Kerl, Lars E French, Alexander A Navarini
Due to the increasingly widespread use and side effect profile of epidermal growth factor receptor inhibitors (EGFRIs), cutaneous side effects of these drugs are frequently encountered. The EGFR is expressed on keratinocytes and fibroblasts. Inhibition of EGFR can produce a range of cutaneous adverse effects, the most frequent being a characteristic acneiform skin eruption. As the latter is associated with good anti-neoplastic responses, the onset of EGFRI-induced acneiform skin eruption is typically viewed as a positive sign by patients and physicians...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28345255/lichenoid-folliculitis-a-unifying-concept
#14
Mamina M Turegano, Leonard C Sperling
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution)...
March 26, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28067422/epidermal-psoriasiform-hyperplasia-an-unrecognized-sign-of-folliculitis-decalvans-a-histological-study-of-26-patients
#15
Bruno Matard, Benedicte Cavelier-Balloy, Pascal Reygagne
BACKGROUND: Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities between FD and HS led us to look for epidermal hyperplasia and follicular hyperkeratosis in FD patients. PATIENTS AND METHOD: We performed a retrospective histological analysis of 26 patients with FD...
January 9, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28061825/new-cdh3-mutation-in-the-first-spanish-case-of-hypotrichosis-with-juvenile-macular-dystrophy-a-case-report
#16
Fiona Blanco-Kelly, Luciana Rodrigues-Jacy da Silva, Iker Sanchez-Navarro, Rosa Riveiro-Alvarez, Miguel Angel Lopez-Martinez, Marta Corton, Carmen Ayuso
BACKGROUND: CDH3 on 16q22.1 is responsible for two rare autosomal recessive disorders with hypotrichosis and progressive macular dystrophy: Hypotrichosis with Juvenile Macular Dystrophy and Ectodermal Dysplasia, Ectrodactyly and Macular Dystrophy. We present a new case of Hypotrichosis with Juvenile Macular Dystrophy. CASE PRESENTATION: A Spanish male born in 1998 from non-consanguineous healthy parents with a suspected diagnosis of Keratosis Follicularis Spinulosa Decalvans and Retinitis Pigmentosa Inversa referred to our Genetics Department (IIS-Fundación Jiménez Díaz)...
January 7, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/27846945/primary-cicatricial-alopecia-other-lymphocytic-primary-cicatricial-alopecias-and-neutrophilic-and-mixed-primary-cicatricial-alopecias
#17
REVIEW
Chantal Bolduc, Leonard C Sperling, Jerry Shapiro
Primary cicatricial alopecias can be frustrating for both patients and physicians. Proper diagnosis guides more successful management of these challenging conditions. Part II will cover the remaining lymphocytic primary cicatricial alopecias, which include pseudopelade of Brocq, central centrifugal cicatricial alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. It will also discuss the neutrophilic and mixed primary cicatricial alopecias, namely folliculitis decalvans, dissecting cellulitis, folliculitis keloidalis, folliculitis (acne) necrotica, and erosive pustular dermatosis...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27814407/an-unusual-case-of-folliculitis-spinulosa-decalvans
#18
Wenge Fan, Qingsong Zhang, Linyi Song
We report the case of a 24-year-old man who presented with pustules, atrophic scars, and alopecia on the scalp, along with follicular keratotic papules on the cheeks, chest, abdomen, back, lateral upper arms, thighs, and axillae, of 6 years' duration. A diagnosis of folliculitis spinulosa decalvans (FSD) was made based on the clinical manifestation and histopathological findings. Dental examination also revealed dental anomalies and a fissured tongue, which are not known to be related to FSD. We provide an overview of the characteristic findings of FSD as well as a review of previously reported cases...
September 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27721552/isotretinoin-induced-acute-severe-myopathy-involving-pelvic-girdle-muscles-a-case-report
#19
Farah Sameem, Semira
Oral isotretinoin has been in widespread use for more than three decades. It causes numerous side effects; skin and mucous membrane being commonly involved. Musculoskeletal adverse effects are also known to occur, but pelvic girdle myopathy is rarely reported. We report myopathy involving pelvic girdle muscles in a young male who received oral isotretinoin for folliculitis decalvans.
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27663151/novel-mbtps2-missense-mutation-causes-a-keratosis-follicularis-spinulosa-decalvans-phenotype-mutation-update-and-review-of-the-literature
#20
J Zhang, Y Wang, R Cheng, C Ni, J Liang, M Li, Z Yao
Keratosis follicularis spinulosa decalvans (KFSD) is an X-linked condition characterized by keratotic follicular papules and progressive alopecia, which is caused by mutations in the MBTPS2 gene. We carried out a genetic study on a child who was suspected clinically to have KFSD. Sanger sequencing was performed to detect mutations in the entire coding region of MBTPS2. A novel missense mutation (c.599C>T) was identified in the patient, confirming a diagnosis of KFSD. We reviewed related cases with MBTPS2 mutations for evidence of genotype-phenotype correlations...
October 2016: Clinical and Experimental Dermatology
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