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https://www.readbyqxmd.com/read/29044686/thiol-ene-clickable-gelatin-a-platform-bioink-for-multiple-3d-biofabrication-technologies
#1
Sarah Bertlein, Gabriella Brown, Khoon S Lim, Tomasz Jungst, Thomas Boeck, Torsten Blunk, Joerg Tessmar, Gary J Hooper, Tim B F Woodfield, Juergen Groll
Bioprinting can be defined as the art of combining materials and cells to fabricate designed, hierarchical 3D hybrid constructs. Suitable materials, so called bioinks, have to comply with challenging rheological processing demands and rapidly form a stable hydrogel postprinting in a cytocompatible manner. Gelatin is often adopted for this purpose, usually modified with (meth-)acryloyl functionalities for postfabrication curing by free radical photopolymerization, resulting in a hydrogel that is cross-linked via nondegradable polymer chains of uncontrolled length...
October 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29034057/design-and-fabrication-of-a-low-cost-three-dimensional-bioprinter
#2
Colton McElheny, Daniel Hayes, Ram Devireddy
Three-dimensional (3D) bioprinting offers innovative research vectors for tissue engineering. However, commercially available bioprinting platforms can be cost prohibitive to small research facilities, especially in an academic setting. The goal is to design and fabricate a low-cost printing platform able to deliver cell-laden fluids with spatial accuracy along the X, Y, and Z axes of 0.1 mm. The bioprinter consists of three subassemblies: a base unit, a gantry, and a shuttle component. The platform utilizes four stepper motors to position along three axes and a fifth stepper motor actuating a pump...
December 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29030959/ipsc-derived-vascular-cell-spheroids-as-building-blocks-for-scaffold-free-biofabrication
#3
Leni Moldovan, April Barnard, Chang-Hyun Gil, Y Lin, Maria B Grant, Mervin C Yoder, Nutan Prasain, Nicanor I Moldovan
Recently a protocol was established to obtain large quantities of human induced pluripotent stem cells (iPSC)-derived endothelial progenitors, called endothelial colony forming cells (ECFC), and of candidate smooth-muscle forming cells (SMFC). Here, we tested their suitability for assembling in spheroids, and in larger 3D cell constructs. iPSC-derived ECFC and SMFC were labeled with tdTomato and eGFP, respectively. Spheroids were formed in ultra-low adhesive wells, and their dynamic proprieties were studied by time-lapse microscopy, or by confocal microscopy...
October 14, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29025676/a-simple-and-efficient-feeder-free-culture-system-to-up-scale-ipscs-on-polymeric-material-surface-for-use-in-3d-bioprinting
#4
Chui-Wei Wong, You-Tzung Chen, Chung-Liang Chien, Tien-Yu Yu, Syang-Peng Rwei, Shan-Hui Hsu
The 3D bioprinting and cell/tissue printing techniques open new possibilities for future applications. To facilitate the 3D bioprinting process, a large amount of living cells are required. Induced pluripotent stem cells (iPSCs) represent a promising cell source for bioprinting. However, the maintenance and expansion of undifferentiated iPSCs are expensive and time consuming. Therefore, in this study a culture method to obtain a sufficient amount of healthy and undifferentiated iPSCs in a short-term period was established...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024044/4d-biofabrication-using-shape-morphing-hydrogels
#5
Alina Kirillova, Ridge Maxson, Georgi Stoychev, Cheryl T Gomillion, Leonid Ionov
Despite the tremendous potential of bioprinting techniques toward the fabrication of highly complex biological structures and the flourishing progress in 3D bioprinting, the most critical challenge of the current approaches is the printing of hollow tubular structures. In this work, an advanced 4D biofabrication approach, based on printing of shape-morphing biopolymer hydrogels, is developed for the fabrication of hollow self-folding tubes with unprecedented control over their diameters and architectures at high resolution...
October 12, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29017117/characterisation-of-hyaluronic-acid-methylcellulose-hydrogels-for-3d-bioprinting
#6
Nicholas Law, Brandon Doney, Hayley Glover, Yahua Qin, Zachary M Aman, Timothy B Sercombe, Lawrence J Liew, Rodney J Dilley, Barry J Doyle
Hydrogels containing hyaluronic acid (HA) and methylcellulose (MC) have shown promising results for three dimensional (3D) bioprinting applications. However, several parameters influence the applicability bioprinting and there is scarce data in the literature characterising HAMC. We assessed eight concentrations of HAMC for printability, swelling and stability over time, rheological and structural behaviour, and viability of mesenchymal stem cells. We show that HAMC blends behave as viscous solutions at 4°C and have faster gelation times at higher temperatures, typically gelling upon reaching 37°C...
September 28, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28990579/bone-matrix-production-in-hydroxyapatite-modified-hydrogels-suitable-for-bone-bioprinting
#7
Annika Wenz, Kirsten Borchers, Günter E M Tovar, Petra Kluger
Though bioprinting is a forward-looking approach in bone tissue engineering, the development of bioinks which are on the one hand processable with the chosen printing technique, and on the other hand possess the relevant mechanical as well as osteoconductive features remains a challenge. In the present study, polymer solutions based on methacrylated gelatin and methacrylated hyaluronic acid modified with hydroxyapatite particles (5 wt%) were prepared. Encapsulation of primary human adipose-derived stem cells in the hydroxyapatite-containing gels and culture for 28 days resulted in a storage moduli significantly increased to126...
October 9, 2017: Biofabrication
https://www.readbyqxmd.com/read/28985202/3d-bioprinting-using-stem-cells
#8
REVIEW
Chin Siang Ong, Pooja Yesantharao, Chen Yu Huang, Gunnar Mattson, Joseph Boktor, Takuma Fukunishi, Huaitao Zhang, Narutoshi Hibino
Recent advances have allowed for three-dimensional (3D) printing technologies to be applied to biocompatible materials, cells and supporting components, creating a field of 3D bioprinting that holds great promise for artificial organ printing and regenerative medicine. At the same time, stem cells, such as human induced pluripotent stem cells, have driven a paradigm shift in tissue regeneration and the modeling of human disease, and represent an unlimited cell source for tissue regeneration and the study of human disease...
October 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28981287/nanoengineered-colloidal-inks-for-3d-bioprinting
#9
Charles W Peak, Jean Stein, Karli A Gold, Akhilesh K Gaharwar
Nanoengineered hydrogels offer the potential to design shear-thinning bioinks for three-dimensional (3D) bioprinting. Here, we have synthesized colloidal bioinks composed of disk-shaped two-dimensional (2D) nanosilicates (Laponite) and poly(ethylene glycol) (PEG). The addition of Laponite reinforces the PEG network and increases viscosity, storage modulus and network stability. PEG-Laponite hydrogels display shear-thinning and self-recovery characteristics due to rapid internal phase rearrangement. As a result, a range of complex pattern can be printed using PEG-Laponite bioinks...
October 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28976364/assessing-bioink-shape-fidelity-to-aid-material-development-in-3d-bioprinting
#10
Alexandre Ribeiro, Maarten Michiel Blokzijl, Riccardo Levato, Claas Willem Visser, Miguel Castilho, Wim E Hennink, Tina Vermonden, Jos Malda
During extrusion-based bioprinting, the deposited bioink filaments are subjected to deformations, such as collapse of overhanging filaments, which compromises the ability to stack several layers of bioink, and fusion between adjacent filaments, which compromises the resolution and maintenance of a desired pore structure. When developing new bioinks, approaches to assess their shape fidelity after printing would be beneficial to evaluate the degree of deformation of the deposited filament and to estimate how similar the final printed construct would be to the design...
October 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28975895/pla-short-i-sub-micron-fibers-i-reinforcement-of-3d-bioprinted-alginate-constructs-for-cartilage-regeneration
#11
Alicja Kosik-Kozioł, Marco Costantini, Tomasz Bolek, Krisztina Szoke, Andrea Barbetta, Jan E Brinchmann, Wojciech Święszkowski
In this study, we present an innovative strategy to reinforce 3D printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short sub-micron polylactide (PLA) fibers. We demonstrate that Young's modulus obtained for pristine alginate constructs (6.9 ± 1.7 kPa) can be increased threefold (up to 25.1 ± 3.8 kPa) with the addition of PLA short fibers. Furthermore, to assess the performance of such materials in cartilage tissue engineering, we loaded the bioinks with human chondrocytes and cultured in vitro the bioprinted constructs for up to 14 days...
October 4, 2017: Biofabrication
https://www.readbyqxmd.com/read/28966095/3d-printing-of-hybrid-biomaterials-for-bone-tissue-engineering-calcium-polyphosphate-microparticles-encapsulated-by-polycaprolactone
#12
Meik Neufurth, Xiaohong Wang, Shunfeng Wang, Renate Steffen, Maximilian Ackermann, Natalie D Haep, Heinz C Schröder, Werner E G Müller
Here we describe the formulation of a morphogenetically active bio-ink consisting of amorphous microparticles (MP) prepared from Ca(2+) and the physiological inorganic polymer, polyphosphate (polyP). Those MP had been fortified by mixing with poly-ε-caprolactone (PCL) to allow 3D-bioprinting. The resulting granular PCL/Ca-polyP-MP hybrid material, liquefied by short-time heating to 100°C, was used for the 3D-printing of tissue-like scaffolds formed by strands with a thickness of 400 µm and a stacked architecture leaving ≈0...
September 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28952550/3d-bioprinting-and-in-vitro-cardiovascular-tissue-modeling
#13
REVIEW
Jinah Jang
Numerous microfabrication approaches have been developed to recapitulate morphologically and functionally organized tissue microarchitectures in vitro; however, the technical and operational limitations remain to be overcome. 3D printing technology facilitates the building of a construct containing biomaterials and cells in desired organizations and shapes that have physiologically relevant geometry, complexity, and micro-environmental cues. The selection of biomaterials for 3D printing is considered one of the most critical factors to achieve tissue function...
August 18, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952542/3d-printing-and-3d-bioprinting-in-pediatrics
#14
Sanjairaj Vijayavenkataraman, Jerry Y H Fuh, Wen Feng Lu
Additive manufacturing, commonly referred to as 3D printing, is a technology that builds three-dimensional structures and components layer by layer. Bioprinting is the use of 3D printing technology to fabricate tissue constructs for regenerative medicine from cell-laden bio-inks. 3D printing and bioprinting have huge potential in revolutionizing the field of tissue engineering and regenerative medicine. This paper reviews the application of 3D printing and bioprinting in the field of pediatrics.
July 13, 2017: Bioengineering
https://www.readbyqxmd.com/read/28952482/polysaccharide-fabrication-platforms-and-biocompatibility-assessment-as-candidate-wound-dressing-materials
#15
REVIEW
Donald C Aduba, Hu Yang
Wound dressings are critical for wound care because they provide a physical barrier between the injury site and outside environment, preventing further damage or infection. Wound dressings also manage and even encourage the wound healing process for proper recovery. Polysaccharide biopolymers are slowly becoming popular as modern wound dressings materials because they are naturally derived, highly abundant, inexpensive, absorbent, non-toxic and non-immunogenic. Polysaccharide biopolymers have also been processed into biomimetic platforms that offer a bioactive component in wound dressings that aid the healing process...
January 18, 2017: Bioengineering
https://www.readbyqxmd.com/read/28936512/magnetic-janus-particles-synthesized-using-droplet-micro-magnetofluidic-techniques-for-protein-detection
#16
V B Varma, R G Wu, Z P Wang, R V Ramanujan
Magnetic droplets on a microfluidic platform can act as micro-robots, providing wireless, remote, and programmable control. This field of droplet micro-magnetofluidics (DMMF) is useful for droplet merging, mixing and synthesis of Janus structures. Specifically, magnetic Janus particles (MJP) are useful for protein and DNA detection as well as magnetically controlled bioprinting. However, synthesis of MJP with control of the functional phases is a challenge. Hence, we developed a high flow rate, surfactant-free, wash-less method to synthesize MJP by integration of DMMF with hybrid magnetic fields...
October 11, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28936182/corrigendum-microtissues-enhance-smooth-muscle-differentiation-and-cell-viability-of-hadscs-for-three-dimensional-bioprinting
#17
Yipeng Jin, Yongde Xu, Yuanyi Wu, Jilei Sun, Jiaxiang Guo, Jiangping Gao, Yong Yang
[This corrects the article on p. 534 in vol. 8, PMID: 28790931.].
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28934880/three-dimensional-bioprinting-and-its-potential-in-the-field-of-articular-cartilage-regeneration
#18
Vivian H M Mouser, Riccardo Levato, Lawrence J Bonassar, Darryl D D'Lima, Daniel A Grande, Travis J Klein, Daniel B F Saris, Marcy Zenobi-Wong, Debby Gawlitta, Jos Malda
Three-dimensional (3D) bioprinting techniques can be used for the fabrication of personalized, regenerative constructs for tissue repair. The current article provides insight into the potential and opportunities of 3D bioprinting for the fabrication of cartilage regenerative constructs. Although 3D printing is already used in the orthopedic clinic, the shift toward 3D bioprinting has not yet occurred. We believe that this shift will provide an important step forward in the field of cartilage regeneration. Three-dimensional bioprinting techniques allow incorporation of cells and biological cues during the manufacturing process, to generate biologically active implants...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28930358/fabrication-and-characterization-of-a-3d-bioprinted-nanoparticle-hydrogel-hybrid-device-for-biomimetic-detoxification
#19
Maggie S Chen, Yue Zhang, Liangfang Zhang
A biomimetic micro/nanodevice is 3D bioprinted using polyethylene glycol (PEG) hydrogel as the supporting platform, along with the red blood cell (RBC) membrane-coated nanoparticles (RBC-NPs) encapsulated in the hydrogel as the detoxification mechanism. RBC-NPs are prepared through a nanoprecipitation and coating method and then mixed into the poly(ethylene glycol) diacrylate (PEGDA) monomer solution for 3D bioprinting through photopolymerization. This resulting detoxification device is engineered with multiple inner channels for the RBC-NPs to nonspecifically soak up the various toxins flowing through the channels...
October 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28930091/proposal-to-assess-printability-of-bioinks-for-extrusion-based-bioprinting-and-evaluation-of-rheological-properties-governing-bioprintability
#20
Naomi Claire Paxton, Willi Smolan, Thomas Böck, Ferry P W Melchels, Juergen Groll, Tomasz Juengst
The development and formulation of printable inks for extrusion-based 3D bioprinting has been a major challenge in the field of biofabrication. Inks, often polymer solutions with the addition of crosslinking to form hydrogels, must not only display adequate mechanical properties for the chosen application, but also show high biocompatibility as well as printability. Here we describe a reproducible two-step method for the assessment of the printability of inks for bioprinting, focussing firstly on screening ink formulations to assess fibre formation and the ability to form 3D constructs before presenting a method for the rheological evaluation of inks to characterise the yield point, shear thinning and recovery behaviour...
September 20, 2017: Biofabrication
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