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https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#1
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29451481/-laser-assisted-bioprinting-a-novel-approach-for-bone-regeneration-applications
#2
Hugo Oliveira, Nathalie Dusserre, Davit Hakobyan, Jean-Christophe Fricain
No abstract text is available yet for this article.
February 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29451384/a-highly-elastic-biodegradable-single-network-hydrogel-for-cell-printing
#3
Cancan Xu, Wenhan Lee, Guohao Dai, Yi Hong
Cell printing is becoming a common technique to fabricate cellularized printed-scaffold for biomedical application. There are still significant challenges in soft tissue bioprinting using hydrogels which requires live cells inside the hydrogels. Moreover, the resilient mechanical properties from hydrogels are also required to mechanically mimic the native soft tissues. Herein, we developed a visible-light crosslinked, single-network, biodegradable hydrogel with high elasticity and flexibility for cell printing, which is different from previous highly elastic hydrogel with double-network and two-components...
February 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#4
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29445812/3d-cellular-structures-and-co-cultures-formed-through-the-contactless-magnetic-manipulation-of-cells-on-adherent-surfaces
#5
Abdel Rahman Abdel Fattah, Sarah Mishriki, Tobias Kammann, Rakesh P Sahu, Fei Geng, Ishwar K Puri
A magnet array is employed to manipulate diamagnetic cells that are contained in paramagnetic medium to demonstrate for the first time the contactless bioprinting of three-dimensional (3D) cellular structures and co-cultures of breast cancer MCF-7 and endothelial HUVEC at prescribed locations on tissue culture treated well plates. Sequential seeding of different cell lines and the spatial displacement of the magnet array creates co-cultured cellular structures within a well without using physically intrusive well inserts...
February 15, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29438729/hyaluronan-chemistries-for-three-dimensional-matrix-applications
#6
REVIEW
Monica A Serban, Aleksander Skardal
Hyaluronan is a ubiquitous constituent of mammalian extracellular matrices and, because of its excellent intrinsic biocompatibility and chemical modification versatility, has been widely employed in a multitude of biomedical applications. In this article, we will survey the approaches used to tailor hyaluronan to specific needs of tissue engineering, regenerative and reconstructive medicine and overall biomedical research. We will also describe recent examples of applications in these broader areas, such as 3D cell culture, bioprinting, organoid biofabrication, and precision medicine that are facilitated by the use of hyaluronan as a biomaterial...
February 10, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29428560/enabling-personalized-implant-and-controllable-biosystem-development-through-3d-printing
#7
REVIEW
Neerajha Nagarajan, Agnes Dupret-Bories, Erdem Karabulut, Pinar Zorlutuna, Nihal Engin Vrana
The impact of additive manufacturing in our lives has been increasing constantly. One of the frontiers in this change is the medical devices. 3D printing technologies not only enable the personalization of implantable devices with respect to patient-specific anatomy, pathology and biomechanical properties but they also provide new opportunities in related areas such as surgical education, minimally invasive diagnosis, medical research and disease models. In this review, we cover the recent clinical applications of 3D printing with a particular focus on implantable devices...
February 8, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29425719/cell-reprogramming-by-3d-bioprinting-of-human-fibroblasts-in-polyurethane-hydrogel-for-fabrication-of-neural-like-constructs
#8
Lin Ho, Shan-Hui Hsu
3D bioprinting is a technique which enables the direct printing of biodegradable materials with cells into 3D tissue. So far there is no cell reprogramming in situ performed with the 3D bioprinting process. Forkhead box D3 (FoxD3) is a transcription factor and neural crest marker, which was reported to reprogram human fibroblasts into neural crest stem-like cells. In this study, we synthesized a new biodegradable thermo-responsive waterborne polyurethane (PU) gel as a bioink. FoxD3 plasmids and human fibroblasts were co-extruded with the PU hydrogel through the syringe needle tip for cell reprogramming...
February 6, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29422410/tissue-engineering-3d-neurovascular-units-a-biomaterials-and-bioprinting-perspective
#9
REVIEW
Geoffrey Potjewyd, Samuel Moxon, Tao Wang, Marco Domingos, Nigel M Hooper
Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) components in an important interface whose correct functioning is critical to maintain brain health. Tissue engineering is now offering new tools and insights to advance our understanding of NVU function. Here, we review how the use of novel biomaterials to mimic the mechanical and functional cues of the ECM, coupled with precisely layered deposition of the different cells of the NVU through 3D bioprinting, is revolutionising the study of neurovascular function and dysfunction...
February 5, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29414913/novel-biomaterials-used-in-medical-3d-printing-techniques
#10
REVIEW
Karthik Tappa, Udayabhanu Jammalamadaka
The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and pharmaceutical fields. A vast variety of biomaterials are currently being used in medical 3D printing, including metals, ceramics, polymers, and composites. With continuous research and progress in biomaterials used in 3D printing, there has been a rapid growth in applications of 3D printing in manufacturing customized implants, prostheses, drug delivery devices, and 3D scaffolds for tissue engineering and regenerative medicine...
February 7, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29414466/influence-of-crosslinking-on-the-mechanical-behavior-of-3d-printed-alginate-scaffolds-experimental-and-numerical-approaches
#11
Saman Naghieh, Mohammad Reza Karamooz-Ravari, M D Sarker, Eva Karki, Xiongbiao Chen
Tissue scaffolds fabricated by three-dimensional (3D) bioprinting are attracting considerable attention for tissue engineering applications. Because the mechanical properties of hydrogel scaffolds should match the damaged tissue, changing various parameters during 3D bioprinting has been studied to manipulate the mechanical behavior of the resulting scaffolds. Crosslinking scaffolds using a cation solution (such as CaCl2) is also important for regulating the mechanical properties, but has not been well documented in the literature...
January 31, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29413501/integration-of-3d-printing-and-additive-manufacturing-in-the-interventional-pulmonologist-s-toolbox
#12
Nicolas Guibert, Laurent Mhanna, Alain Didier, Benjamin Moreno, Pierre Leyx, Gavin Plat, Julien Mazieres, Christophe Hermant
New 3D technologies are rapidly entering into the surgical landscape, including in interventional pulmonology. The transition of 2D restricted data into a physical model of pathological airways by three-dimensional printing (3DP) allows rapid prototyping and fabrication of complex and patient-specific shapes and can thus help the physician to plan and guide complex procedures. Furthermore, computer-assisted designed (CAD) patient-specific devices have already helped surgeons overcome several therapeutic impasses and are likely to rapidly cover a wider range of situations...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29405607/a-novel-well-resolved-direct-laser-bioprinting-system-for-rapid-cell-encapsulation-and-microwell-fabrication
#13
Zongjie Wang, Xian Jin, Zhenlin Tian, Frederic Menard, Jonathan F Holzman, Keekyoung Kim
A direct laser bioprinting (DLBP) system is introduced in this work. The DLBP system applies visible-laser-induced photo-crosslinking at a wavelength of 405 nm using the photoinitiator VA-086. It is shown that such a system can fabricate vertical structures with fine features (less than 50 µm) and high cell viability (greater than 95%). Experimental characterizations and theoretical simulations are presented, and good agreement is seen between the experiments and theory. The DLBP system is applied to the fabrication of (1) cell-laden hydrogel microgrids, (2) hydrogel microwells, as well as a test of (3) cell encapsulation, and (4) cell seeding...
February 5, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29405059/3d-bioprinting-of-low-concentration-cell-laden-gelatin-methacrylate-gelma-bioinks-with-two-step-crosslinking-strategy
#14
Jun Yin, Mengling Yan, Yancheng Wang, Jianzhong Fu, Hairui Suo
Methacrylated gelatin (GelMA) has been widely used as the tissue engineered scaffold material, but only low concentration GelMA hydrogels were found to be promising cell-laden bioinks with excellent cell viability. In this work, we reported a strategy for precisely deposition of 5% (w/v) cell-laden GelMA bioinks into controlled micro-architectures with high cell viability using extrusion-based three-dimensional (3D) bioprinting. By adding gelatin into GelMA bioinks, a two-step crosslinking combining the rapid and reversible thermo-crosslinking of gelatin with irreversible photo-crosslinking of GelMA was achieved...
February 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29404520/liver-tissue-engineering-from-implantable-tissue-to-whole-organ-engineering
#15
REVIEW
Giuseppe Mazza, Walid Al-Akkad, Krista Rombouts, Massimo Pinzani
The term "liver tissue engineering" summarizes one of the ultimate goals of modern biotechnology: the possibility of reproducing in total or in part the functions of the liver in order to treat acute or chronic liver disorders and, ultimately, create a fully functional organ to be transplanted or used as an extracorporeal device. All the technical approaches in the area of liver tissue engineering are based on allocating adult hepatocytes or stem cell-derived hepatocyte-like cells within a three-dimensional structure able to ensure their survival and to maintain their functional phenotype...
February 2018: Hepatology communications
https://www.readbyqxmd.com/read/29404374/bioprinting-of-skin-constructs-for-wound-healing
#16
REVIEW
Peng He, Junning Zhao, Jiumeng Zhang, Bo Li, Zhiyuan Gou, Maling Gou, Xiaolu Li
Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy...
2018: Burns and trauma
https://www.readbyqxmd.com/read/29401368/three-dimensional-technologies-in-orthopedics
#17
Panayiotis J Papagelopoulos, Olga D Savvidou, Panagiotis Koutsouradis, George D Chloros, Ioanna K Bolia, Vasileios I Sakellariou, Vasileios A Kontogeorgakos, Ioannis I Mavrodontis, Andreas F Mavrogenis, Panos Diamantopoulos
New 3-dimensional digital technologies are revolutionizing orthopedic clinical practice, allowing structures of any complexity to be manufactured in just hours. Such technologies can make surgery for complex cases more precise, more cost-effective, and possibly easier to perform. Applications include pre-operative planning, surgical simulation, patient-specific instrumentation and implants, bioprinting, prosthetics, and orthotics. The basic principles of 3- dimensional technologies, including imaging, design, numerical simulation, and printing, and their current applications in orthopedics are reviewed...
January 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29393630/visible-light-induced-hydrogelation-of-an-alginate-derivative-and-application-to-stereolithographic-bioprinting-using-a-visible-light-projector-and-acid-red
#18
Shinji Sakai, Hidenori Kamei, Toko Mori, Tomoki Hotta, Hiromi Ohi, Masaki Nakahata, Masahito Taya
Visible light-induced hydrogelation is attractive for various biomedical applications. In this study, hydrogels of alginate with phenolic hydroxyl groups (Alg-Ph) were obtained by irradiating a solution containing the polymer, ruthenium II trisbipyridyl chloride ([Ru(bpy)3]2+) and sodium persulfate (SPS), with visible light. The hydrogelation kinetics and the mechanical properties of the resultant hydrogels were tunable by controlling the intensity of the light and the concentrations of [Ru(bpy)3]2+ and SPS...
February 2, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29383354/applying-macromolecular-crowding-to-3d-bioprinting-fabrication-of-3d-hierarchical-porous-collagen-based-hydrogel-constructs
#19
Wei Long Ng, Min Hao Goh, Wai Yee Yeong, May Win Naing
Native tissues and/or organs possess complex hierarchical porous structures that confer highly-specific cellular functions. Despite advances in fabrication processes, it is still very challenging to emulate the hierarchical porous collagen architecture found in most native tissues. Hence, the ability to recreate such hierarchical porous structures would result in biomimetic tissue-engineered constructs. Here, a single-step drop-on-demand (DOD) bioprinting strategy is proposed to fabricate hierarchical porous collagen-based hydrogels...
January 31, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29378379/-biofabrication-new-approaches-for-tissue-regeneration
#20
Raymund E Horch, Annika Weigand, Harald Wajant, Jürgen Groll, Aldo R Boccaccini, Andreas Arkudas
BACKGROUND: The advent of Tissue Engineering (TE) in the early 1990ies was fostered by the increasing need for functional tissue and organ replacement. Classical TE was based on the combination of carrier matrices, cells and growth factors to reconstitute lost or damaged tissue and organs. Despite considerable results in vitro and in experimental settings the lack of early vascularization has hampered its translation into daily clinical practice so far. A new field of research, called "biofabrication" utilizing latest 3D printing technologies aims at hierarchically and spatially incorporating different cells, biomaterials and molecules into a matrix to alleviate a directed maturation of artificial tissue...
January 29, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
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