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https://www.readbyqxmd.com/read/27936505/commentary-on-bora-zorlu-2017-social-cognition-deficits-in-addiction-an-attachment-problem
#1
Charles Kornreich
No abstract text is available yet for this article.
January 2017: Addiction
https://www.readbyqxmd.com/read/27936502/commentary-on-morgenstern-et-al-2017-party-themed-advertisements-and-initiation-of-alcohol-consumption
#2
Neo K Morojele, Charles D H Parry
No abstract text is available yet for this article.
January 2017: Addiction
https://www.readbyqxmd.com/read/27936396/gnpat-p-d519g-is-independently-associated-with-markedly-increased-iron-stores-in-hfe-p-c282y-homozygotes
#3
James C Barton, Wen-Pin Chen, Mary J Emond, Pradyumna D Phatak, V Nathan Subramaniam, Paul C Adams, Lyle C Gurrin, Gregory J Anderson, Grant A Ramm, Lawrie W Powell, Katrina J Allen, John D Phillips, Charles J Parker, Gordon D McLaren, Christine E McLaren
BACKGROUND: GNPAT p.D519G positivity is significantly increased in HFE p.C282Y homozygotes with markedly increased iron stores. We sought to determine associations of p.D519G and iron-related variables with iron stores in p.C282Y homozygotes. METHODS: We defined markedly increased iron stores as serum ferritin >2247pmol/L (>1000μg/L) and either hepatic iron >236μmol/g dry weight or iron >10g by induction phlebotomy (men and women). We defined normal or mildly elevated iron stores as serum ferritin <674...
November 12, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27936368/utility-of-brief-versions-of-the-alcohol-use-disorders-identification-test-audit-to-identify-excessive-drinking-among-patients-in-hiv-care-in-south-africa
#4
Neo K Morojele, Sebenzile Nkosi, Connie T Kekwaletswe, Paul A Shuper, Samuel O Manda, Bronwyn Myers, Charles D H Parry
OBJECTIVE: In sub-Saharan Africa, large proportions of patients who are on antiretroviral therapy (ART) engage in excessive alcohol use, which may lead to adverse health consequences and may go undetected. Consequently, health care workers need brief screening tools to be able to routinely identify and manage excessive alcohol use among their patients. Various brief versions of the valid and reliable 10-item Alcohol Use Disorders Identification Test (AUDIT) (i.e., the AUDIT-C, AUDIT-3, AUDIT-QF, AUDIT-PC, AUDIT-4, and m-FAST) may potentially replace the full AUDIT in busy HIV care settings...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936365/how-much-is-too-much-patterns-of-drinking-during-alcohol-treatment-and-associations-with-post-treatment-outcomes-across-three-alcohol-clinical-trials
#5
Katie Witkiewitz, Corey R Roos, Matthew R Pearson, Kevin A Hallgren, Stephen A Maisto, Megan Kirouac, Alyssa A Forcehimes, Adam D Wilson, Charles S Robinson, Elizabeth McCallion, J Scott Tonigan, Nick Heather
OBJECTIVE: This secondary data analysis examined patterns of drinking during alcohol treatment and associated drinking outcomes during the first year following treatment. The goal was to provide clinicians with guidance on which patients may be most at risk for negative long-term outcomes based on drinking patterns during treatment. METHOD: This study was an analysis of existing data (N = 3,851) from three randomized clinical trials for alcohol use disorder: the COMBINE Study (n = 1,383), Project MATCH (n = 1,726), and the United Kingdom Alcohol Treatment Trial (n = 742)...
January 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27936225/evaluation-of-antigens-for-development-of-a-serological-test-for-human-african-trypanosomiasis
#6
Sylvain Biéler, Harald Waltenberger, Michael P Barrett, Richard McCulloch, Jeremy C Mottram, Mark Carrington, Wilhelm Schwaeble, James McKerrow, Margaret A Phillips, Paul A Michels, Philippe Büscher, Jean-Charles Sanchez, Richard Bishop, Derrick R Robinson, James Bangs, Michael Ferguson, Barbara Nerima, Audrey Albertini, Gerd Michel, Magdalena Radwandska, Joseph Mathu Ndung'u
BACKGROUND: Control and elimination of human African trypanosomiasis (HAT) can be accelerated through the use of diagnostic tests that are more accurate and easier to deploy. The goal of this work was to evaluate the immuno-reactivity of antigens and identify candidates to be considered for development of a simple serological test for the detection of Trypanosoma brucei gambiense or T. b. rhodesiense infections, ideally both. METHODOLOGY/PRINCIPAL FINDINGS: The reactivity of 35 antigens was independently evaluated by slot blot and ELISA against sera from both T...
2016: PloS One
https://www.readbyqxmd.com/read/27935944/novel-and-lost-forests-in-the-upper-midwestern-united-states-from-new-estimates-of-settlement-era-composition-stem-density-and-biomass
#7
Simon J Goring, David J Mladenoff, Charles V Cogbill, Sydne Record, Christopher J Paciorek, Stephen T Jackson, Michael C Dietze, Andria Dawson, Jaclyn Hatala Matthes, Jason S McLachlan, John W Williams
BACKGROUND: EuroAmerican land-use and its legacies have transformed forest structure and composition across the United States (US). More accurate reconstructions of historical states are critical to understanding the processes governing past, current, and future forest dynamics. Here we present new gridded (8x8km) reconstructions of pre-settlement (1800s) forest composition and structure from the upper Midwestern US (Minnesota, Wisconsin, and most of Michigan), using 19th Century Public Land Survey System (PLSS), with estimates of relative composition, above-ground biomass, stem density, and basal area for 28 tree types...
2016: PloS One
https://www.readbyqxmd.com/read/27935690/an-international-inter-laboratory-digital-pcr-study-demonstrates-high-reproducibility-for-the-measurement-of-a-rare-sequence-variant
#8
Alexandra S Whale, Alison S Devonshire, George A Karlin-Neumann, Jack Regan, Leanne Javier, Simon Cowen, Ana Fernandez-Gonzalez, Gerwyn M Jones, Nicholas Redshaw, Julia Beck, Andreas W Berger, Valerie Combaret, Nina Dahl Kjersgaard, Lisa Davis, Frederic Fina, Tim Forshew, Rikke Fredslund Andersen, Silvia Galbiati, Álvaro González Hernández, Charles A Haynes, Filip Janku, Roger Lacave, Justin Lee, Vilas Mistry, Alexandra Pender, Anne Pradines, Charlotte Proudhon, Lao H Saal, Elliot Stieglitz, Bryan Ulrich, Carole A Foy, Helen Parkes, Svilen Tzonev, Jim Francis Huggett
This study tested the claim that digital PCR (dPCR) can offer highly reproducible quantitative measurements in disparate labs. Twenty-one laboratories measured four blinded samples containing different quantities of a KRAS fragment encoding G12D, an important genetic marker for guiding therapy of certain cancers. This marker is challenging to quantify reproducibly using qPCR or NGS due to the presence of competing wild type sequences and the need for calibration. Using dPCR, eighteen laboratories were able to quantify the G12D marker within 12% of each other in all samples...
December 9, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27935430/human-runners-exhibit-a-least-variable-gait-speed
#9
Pei Hua Cher, Charles J Worringham, Ian B Stewart
This study characterises the relationship between gait variability and speed in runners using data from trunk accelerations in each axis. Twelve participants of varying fitness ran on the treadmill with three sessions of six randomly ordered self-selected speeds. A VO2max test was conducted on the fourth session. Running gait was tracked with inertial sensors. The occurrence of a mid-range speed was analysed for the anterior-posterior, vertical and lateral directional coefficient of variation (CV) of root mean square (RMS) acceleration data...
December 9, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27935058/bimodal-targeting-using-sulfonated-mannosylated-pei-for-combined-gene-delivery-and-photodynamic-therapy
#10
Upendra Chitgupi, Yi Li, Mingfu Chen, Shuai Shao, Marie Beitelshees, Myles Joshua Tan, Sriram Neelamegham, Blaine A Pfeifer, Charles Jones, Jonathan F Lovell
Photodynamic therapy (PDT) and gene delivery have both been used to target both cancer cells and tumor-associated macrophages (TAMs). Given the complex nature of tumor tissue, there could be merit in combining these strategies simultaneously. In this study, we developed a bimodal targeting approach to both cancer cells and macrophages, employing materials conducive to both gene delivery and PDT. Polymers libraries were created that consisted of cationic polyethyleneimine (PEI) conjugated to the photosensitizer pyropheophorbide-α, with sulfonation (to target selectin-expressing cells) and mannosylation (to target TAMs)...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27934903/unlocking-bat-immunology-establishment-of-pteropus-alecto-bone-marrow-derived-dendritic-cells-and-macrophages
#11
Peng Zhou, Yok Teng Chionh, Sergio Erdal Irac, Matae Ahn, Justin Han Jia Ng, Even Fossum, Bjarne Bogen, Florent Ginhoux, Aaron T Irving, Charles-Antoine Dutertre, Lin-Fa Wang
Bats carry and shed many emerging infectious disease agents including Ebola virus and SARS-like Coronaviruses, yet they rarely display clinical symptoms of infection. Bat epithelial or fibroblast cell lines were previously established to study the bat immune response against viral infection. However, the lack of professional immune cells such as dendritic cells (DC) and macrophages has greatly limited the significance of current investigations. Using Pteropus alecto (P. alecto) GM-CSF plus IL4, FLT3L and CSF-1, we successfully generated bat bone marrow-derived DC and macrophages...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934841/aeromonas-hydrophila-meningitis-and-fulminant-sepsis-in-preterm-newborn-a-case-report-and-review-of-literature
#12
A Kali, R Kalaivani, Pmv Charles, K S Seetha
Neonatal meningitis is a lethal infection occurring in the 1st month of life. The risk of developing permanent neurological sequels is high among the neonates who survive. Bacterial pathogens are commonly associated with this condition. Aeromonas is a Gram-negative bacteria of aquatic habitat. Although isolation of Aeromonas species from neonates with blood stream infection is infrequently reported, neonatal meningitis caused by Aeromonas is exceedingly rare. We present a case of fulminant sepsis and meningitis caused by Aeromonas hydrophila in a preterm newborn male...
October 2016: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27934774/the-moral-agency-of-institutions-effectively-using-expert-nurses-to-support-patient-autonomy
#13
Sonya Charles
Patient autonomy-with an emphasis on informed consent and the right to refuse treatment-is a cornerstone of modern bioethics. Within discussions about patient autonomy, feminist bioethicists have argued for a relational approach to autonomy. Under a relational framework, we must look beyond the individual moment of choice to include the role relationships and specific contexts can play in supporting or undermining autonomy. Given the day-to-day interactions they have with patients, nurses play a significant role in helping patients understand the nature of their illnesses and make truly informed decisions...
December 1, 2016: Journal of Medical Ethics
https://www.readbyqxmd.com/read/27934718/reforming-the-u-s-coal-leasing-program
#14
Kenneth Gillingham, James Bushnell, Meredith Fowlie, Michael Greenstone, Charles Kolstad, Alan Krupnick, Adele Morris, Richard Schmalensee, James Stock
No abstract text is available yet for this article.
December 2, 2016: Science
https://www.readbyqxmd.com/read/27934296/identification-of-candidate-host-cell-factors-required-for-actin-based-motility-of-burkholderia-pseudomallei
#15
Niramol Jitprasutwit, Nurhamimah Zainal-Abidin, Charles Vander Broek, Dominic Kurian, Sunee Korbsrisate, Mark P Stevens, Joanne M Stevens
Intracellular actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires the bacterial factor BimA. Located at one pole of the bacterium, BimA recruits and polymerizes cellular actin to promote bacterial motility within and between cells. Here, we describe an affinity approach coupled with mass spectrometry to identify cellular proteins recruited to BimA-expressing bacteria under conditions that promote actin polymerization. We identified a group of cellular proteins that are recruited to the B...
December 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27934172/crystal-engineering-for-low-defect-density-and-high-efficiency-hybrid-chemical-vapor-deposition-grown-perovskite-solar-cells
#16
Annie Ng, Zhiwei Ren, Qian Shen, Sin Hang Cheung, Huseyin Cem Gokkaya, Shu Kong So, Aleksandra B Djurišić, Yangyang Wan, Xiaojun Wu, Charles Surya
Synthesis of high quality perovskite absorber is a key factor in determining the performance of the solar cells. We demonstrate that hybrid chemical vapor deposition (HCVD) growth technique can provide high level of versatility and repeatability to ensure the optimal conditions for the growth of the perovskite films as well as potential for batch processing. It is found that the growth ambient and degree of crystallization of CH3NH3PbI3 (MAPI) have strong impact on the defect density of MAPI. We demonstrate that HCVD process with slow postdeposition cooling rate can significantly reduce the density of shallow and deep traps in the MAPI due to enhanced material crystallization, while a mixed O2/N2 carrier gas is effective in passivating both shallow and deep traps...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27933866/identification-of-hydrogen-disulfanes-and-hydrogen-trisulfanes-in-h2s-bottle-in-flint-and-in-dry-mineral-white-wine
#17
Christian Starkenmann, Charles Jean-Francois Chappuis, Yvan Niclass, Pascale Deneulin
Through the accidental contamination of a gas cylinder of H2S, the importance of polysulfanes for flint, gun powder, and match odors was discovered. The hydrogen disulfane was prepared from disulfanediylbis[methyl(diphenyl)silane], and its odor descriptor was evaluated in the gas phase from a gas chromatograph coupled to an olfaction port. The occurrence of this compound in flint and pebbles was confirmed by analyses after derivatization with pentafluorobromobenzene. The occurrence of this sulfane was also confirmed in two dry white Swiss Chasselas wines, sorted by a large-scale sensory analysis from 80 bottles and evaluated by 62 wine professionals...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933693/heart-transplantation-in-children-with-intellectual-disability-an-analysis-of-the-unos-database
#18
Alexander N Goel, Amit Iyengar, Kenneth Schowengerdt, Andrew C Fiore, Charles B Huddleston
Heart transplantation in children with intellectual disability (ID) is an issue of debate due to the shortage of available donor organs. We sought to perform the first large-scale retrospective cohort study describing the prevalence and outcomes of heart transplantation in this population. The United Network of Organ Sharing database was queried from 2008 to 2015 for pediatric patients (age <19 years) receiving first, isolated heart transplant. Recipients were divided into three subgroups: definite ID, probable ID, and no ID...
December 9, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27933404/genome-wide-high-content-sirna-screening-identifies-the-alzheimer-s-genetic-risk-factor-fermt2-as-a-major-modulator-of-app-metabolism
#19
Julien Chapuis, Amandine Flaig, Benjamin Grenier-Boley, Fanny Eysert, Virginie Pottiez, Gaspard Deloison, Alexandre Vandeputte, Anne-Marie Ayral, Tiago Mendes, Shruti Desai, Alison M Goate, John S K Kauwe, Florence Leroux, Adrien Herledan, Florie Demiautte, Charlotte Bauer, Fréderic Checler, Ronald C Petersen, Kaj Blennow, Henrik Zetterberg, Lennart Minthon, Vivianna M Van Deerlin, Virginia Man-Yee Lee, Leslie M Shaw, John Q Trojanowski, Marilyn Albert, Abhay Moghekar, Richard O'Brien, Elaine R Peskind, Nicolas Malmanche, Gerard D Schellenberg, Pierre Dourlen, Ok-Ryul Song, Carlos Cruchaga, Philippe Amouyel, Benoit Deprez, Priscille Brodin, Jean-Charles Lambert
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer's disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the "post-GWAS" era. At least 123 genes are located within the 19 susceptibility loci; hence, a conventional approach (studying the genes one by one) would not be time- and cost-effective. We therefore developed a genome-wide, high-content siRNA screening approach and used it to assess the functional impact of gene under-expression on APP metabolism...
December 8, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27933157/absconding-reducing-failure-to-return-in-adult-mental-health-wards
#20
Jill Bailey, Bethan Page, Nokuthula Ndimande, Julie Connell, Charles Vincent
Failing to return from leave from acute psychiatric wards can have a range of negative consequences for patients, relatives and staff. This study used quality improvement methodology to improve the processes around patient leave and time away from the ward. The aim of this study was to improve rates of on-time return from leave by detained and informal patients by 50%. Following a baseline period, four interventions were implemented and refined using PDSA cycles. The main outcome measure was the proportion of periods of leave where the patient returned on time...
2016: BMJ Quality Improvement Reports
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