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https://www.readbyqxmd.com/read/28931242/pfhrp2-deletions-in-the-democratic-republic-of-congo-evidence-of-absence-or-absence-of-evidence
#1
Charles J Woodrow, Caterina Fanello
No abstract text is available yet for this article.
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931140/infection-with-echinostoma-sp-in-a-group-of-travellers-to-lake-tanganyika-tanzania-in-january-2017
#2
Ruth N Chunge, Charles N Chunge
A small group of travellers became infected with Echinostoma sp. after ingesting raw fish which they caught in Lake Tanganyika, Tanzania, in January 2017. The infection was diagnosed by finding the characteristic eggs in stool samples collected over a 2-week period following their return to Kenya. Echinostoma is a genus of parasitic flukes normally known to infect humans in southeast Asia and the Far East. This appears to be the first report of echinostomiasis in East Africa which can be attributed clearly to ingestion of locally caught raw fish...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28931031/reducing-therapeutic-misconception-a-randomized-intervention-trial-in-hypothetical-clinical-trials
#3
Paul P Christopher, Paul S Appelbaum, Debbie Truong, Karen Albert, Louise Maranda, Charles Lidz
BACKGROUND: Participants in clinical trials frequently fail to appreciate key differences between research and clinical care. This phenomenon, known as therapeutic misconception, undermines informed consent to clinical research, but to date there have been no effective interventions to reduce it and concerns have been expressed that to do so might impede recruitment. We determined whether a scientific reframing intervention reduces therapeutic misconception without significantly reducing willingness to participate in hypothetical clinical trials...
2017: PloS One
https://www.readbyqxmd.com/read/28930979/analysis-of-18fdg-pet-ct-imaging-as-a-tool-for-studying-mycobacterium-tuberculosis-infection-and-treatment-in-non-human-primates
#4
Alexander G White, Pauline Maiello, M Teresa Coleman, Jaime A Tomko, L James Frye, Charles A Scanga, Philana Ling Lin, JoAnne L Flynn
Mycobacterium tuberculosis remains the number one infectious agent in the world today. With the emergence of antibiotic resistant strains, new clinically relevant methods are needed that evaluate the disease process and screen for potential antibiotic and vaccine treatments. Positron Emission Tomography/Computed Tomography (PET/CT) has been established as a valuable tool for studying a number of afflictions such as cancer, Alzheimer's disease, and inflammation/infection. Outlined here are a number of strategies that have been employed to evaluate PET/CT images in cynomolgus macaques that are infected intrabronchially with low doses of M...
September 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930959/outcomes-after-concomitant-traumatic-brain-injury-and-hemorrhagic-shock-a-secondary-analysis-from-the-pragmatic-randomized-optimal-platelets-and-plasma-ratios-trial
#5
Samuel M Galvagno, Erin E Fox, Savitri N Appana, Sarah Baraniuk, Patrick L Bosarge, Eileen M Bulger, Rachel A Callcut, Bryan A Cotton, Michael Goodman, Kenji Inaba, Terence O'Keeffe, Martin A Schreiber, Charles E Wade, Thomas M Scalea, John B Holcomb, Deborah M Stein
BACKGROUND: Often the clinician is faced with a diagnostic and therapeutic dilemma in patients with concomitant traumatic brain injury (TBI) and hemorrhagic shock (HS), as rapid deterioration from either can be fatal. Knowledge about outcomes after concomitant TBI and HS may help prioritize the emergent management of these patients. We hypothesized that patients with concomitant TBI and HS (TBI + HS) had worse outcomes and required more intensive care compared with patients with only one of these injuries...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930951/routine-computed-tomography-after-recent-operative-exploration-for-penetrating-trauma-what-injuries-do-we-miss
#6
April E Mendoza, Christopher A Wybourn, Anthony G Charles, Andre R Campbell, Bruce A Cairns, Margaret M Knudson
BACKGROUND: Patients with penetrating trauma who cannot be stabilized undergo operative intervention without preoperative imaging. In such cases, postoperative imaging may reveal additional injuries not identified during the initial operative exploration. The purpose of this study is to explore the utility of postoperative CT imaging in the setting of penetrating trauma. METHODS: This was a retrospective analysis of patients with penetrating trauma treated at an urban Level 1 trauma center between 2010 and 2015...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930915/microvesicle-subsets-in-sepsis-due-to-community-acquired-pneumonia-compared-to-faecal-peritonitis
#7
Hazem M S Lashin, Suchita Nadkarni, Silvia Oggero, Hefin R Jones, Julian C Knight, Charles J Hinds, Mauro Perretti
RATIONALE: Microvesicles (MV) act as a non-soluble means of inter-cellular communication, with effector roles in disease pathogenesis and potentially as biomarkers. Previously, we reported that neutrophil MV expressing alpha-2-macroglobulin (A2MG) are protective in experimental sepsis and associate with survival in a small cohort of patients with sepsis due to community acquired pneumonia (CAP). OBJECTIVES: To characterise MV profiles in sepsis due to CAP or faecal peritonitis (FP) and determine their relation to outcome...
September 19, 2017: Shock
https://www.readbyqxmd.com/read/28930889/the-burden-of-mental-illness-among-veterans-use-of-vha-health-care-services-by-those-with-service-connected-conditions
#8
Charles Maynard, Adam Batten, Chuan-Fen Liu, Karin Nelson, Stephan D Fihn
BACKGROUND: Little is known about how Veterans with service-connected conditions use health care provided by the Veterans Health Administration (VHA). OBJECTIVES: To ascertain what proportion of Veterans with service-connected conditions used VHA health care and whether it varied according to type of condition, combined disability rating, age, sex, military rank, or other characteristics and whether there were differences in receipt of inpatient and outpatient care...
September 19, 2017: Medical Care
https://www.readbyqxmd.com/read/28930867/pancreatic-neuroendocrine-tumors-computed-tomography-enhancement-but-not-histological-grade-correlates-with-tumor-aggression
#9
Motoyo Yano, Sunil Misra, Danielle H Carpenter, Amber Salter, Charles F Hildebolt
OBJECTIVES: The aims of this study were to assess computed tomography enhancement of pancreatic neuroendocrine tumors (NETs), determine correlation with histological vascularity and fibrosis, and identify a biomarker for tumor aggression. METHODS: The arterial and venous enhancement of NET was calculated on computed tomography for 56 patients. Tumor size and vascularity/fibrosis were assessed. Tumor aggression was grouped by World Health Organization and Hochwald grade and the presence of metastases...
September 19, 2017: Pancreas
https://www.readbyqxmd.com/read/28930863/measurement-of-active-and-sedentary-behavior-in-context-of-large-epidemiologic-studies
#10
Charles E Matthews, Sarah Kozey Keadle, Steven C Moore, Dale S Schoeller, Raymond J Carroll, Richard P Troiano, Joshua N Sampson
INTRODUCTION/PURPOSE: To assess the utility of measurement methods that may be more accurate and precise than traditional questionnaire-based estimates of habitual physical activity and sedentary behavior we compared the measurement properties of a past year questionnaire (AARP) and more comprehensive measures: an internet-based 24-hour recall (ACT24), and a variety of estimates from an accelerometer (ActiGraph). METHODS: Participants were 932 adults (50-74 y) in a 12-month study that included reference measures of energy expenditure from doubly labeled water (DLW) and active and sedentary time via activPAL...
September 19, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28930701/leukocyte-telomere-length-t-cell-composition-and-dna-methylation-age
#11
Brian H Chen, Cara L Carty, Masayuki Kimura, Jeremy D Kark, Wei Chen, Shengxu Li, Tao Zhang, Charles Kooperberg, Daniel Levy, Themistocles Assimes, Devin Absher, Steve Horvath, Alexander P Reiner, Abraham Aviv
Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham Heart Study (FHS; n=909) and the Bogalusa Heart study (BHS; n=826)...
September 20, 2017: Aging
https://www.readbyqxmd.com/read/28930563/mass-spectrometry-based-proteomic-analysis-of-the-dna-damage-response
#12
Matthew P Stokes, Yiying Zhu, Charles L Farnsworth
In response to DNA damage, cells have evolved mechanisms to halt cell cycle progression, activate repair, or initiate apoptosis. These DNA damage response (DDR) pathways are critical for cellular survival in response to genomic insult, and play important roles in growth, development, and disease. Historically, mediators of DNA damage response signaling have been studied one or a few proteins at a time. Advances in mass spectrometry instrumentation and enrichment methods now allow for more global analysis of the DDR in cells and tissues...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930349/a-versatile-platform-for-adding-functional-properties-to-amyloid-fibrils
#13
Devon F A Fontaine, Valerie A Ivancic, Michael B Reardon, Noel D Lazo, Charles E Jakobsche
Herein we report the design, synthesis, and testing of prototype members of a family of amyloid-binding molecular tools that can manipulate the fibrils by giving them various new functional properties. Potential applications include manipulating disease-relevant fibrils, developing novel functional nanomaterials, and studying the molecular details of fibril structures.
September 20, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28930022/diagnosis-of-fatal-human-case-of-st-louis-encephalitis-virus-infection-by-metagenomic-sequencing-california-2016
#14
Charles Y Chiu, Lark L Coffey, Jamie Murkey, Kelly Symmes, Hannah A Sample, Michael R Wilson, Samia N Naccache, Shaun Arevalo, Sneha Somasekar, Scot Federman, Doug Stryke, Paul Vespa, Gary Schiller, Sharon Messenger, Romney Humphries, Steve Miller, Jeffrey D Klausner
We used unbiased metagenomic next-generation sequencing to diagnose a fatal case of meningoencephalitis caused by St. Louis encephalitis virus in a patient from California in September 2016. This case is associated with the recent 2015-2016 reemergence of this virus in the southwestern United States.
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28929924/the-search-for-a-subtype-selective-pet-imaging-agent-for-the-gabaa-receptor-complex-evaluation-of-the-radiotracer-11-c-ado-in-nonhuman-primates
#15
Shu-Fei Lin, Frederic Bois, Daniel Holden, Nabeel Nabulsi, Richard Pracitto, Hong Gao, Michael Kapinos, Jo-Ku Teng, Anupama Shirali, Jim Ropchan, Richard E Carson, Charles S Elmore, Neil Vasdev, Yiyun Huang
The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABAA, GABAB, and GABAC groups. The various GABAA subunits with region-specific distributions in the brain subserve different functional and physiological roles. For example, the sedative and anticonvulsive effects of classical benzodiazepines are attributed to the α1 subunit, and the α2 and α3 subunits mediate the anxiolytic effect. To optimize pharmacotherapies with improved efficacy and devoid of undesirable side effects for the treatment of anxiety disorders, subtype-selective imaging radiotracers are required to assess target engagement at GABA sites and determine the dose-receptor occupancy relationships...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28929839/capturing-ecology-in-modeling-approaches-applied-to-environmental-risk-assessment-of-endocrine-active-chemicals-in-fish
#16
Kate S Mintram, A Ross Brown, Samuel K Maynard, Pernille Thorbek, Charles R Tyler
Endocrine active chemicals (EACs) are widespread in freshwater environments and both laboratory and field based studies have shown reproductive effects in fish at environmentally relevant exposures. Environmental risk assessment (ERA) seeks to protect wildlife populations and prospective assessments rely on extrapolation from individual-level effects established for laboratory fish species to populations of wild fish using arbitrary safety factors. Population susceptibility to chemical effects, however, depends on exposure risk, physiological susceptibility, and population resilience, each of which can differ widely between fish species...
September 20, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28929755/nanowires-of-geobacter-sulfurreducens-require-redox-cofactors-to-reduce-metals-in-pore-spaces-too-small-for-cell-passage
#17
Kyle Michelson, Robert A Sanford, Albert J Valocchi, Charles J Werth
Members of the Geobacteraceae family are ubiquitous metal reducers that utilize conductive 'nanowires' to reduce Mn(IV) and Fe(III) oxides in anaerobic sediments. However, it is not currently known if and to what extent the Mn(IV) and Fe(III) oxides in soil grains and low permeability sediments that are sequestered in pore spaces too small for cell passage can be reduced by long-range extracellular electron transport via Geobacter nanowires, and what mechanisms control this reduction. We developed a microfluidic reactor that physically separates Geobacter sulfurreducens from the Mn(IV) mineral birnessite by a 1...
September 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28929748/field-study-of-rice-yield-diminished-by-soil-arsenic-in-bangladesh
#18
Brittany Lynn Huhmann, Charles F Harvey, Anjal Uddin, Imtiaz Choudhury, Kazi M Ahmed, John M Duxbury, Benjamin C Bostick, Alexander Van Geen
Rice was traditionally grown only during the summer (aman) monsoon in Bangladesh but more than half is now grown during the dry winter (boro) season and requires irrigation. A previous field study conducted in a small area irrigated by a single high-arsenic well has shown that the accumulation of arsenic (As) in soil from irrigating with high-As groundwater can reduce rice yield. We investigated the effect of soil As on rice yield under a range of field conditions by exchanging the top 15 cm of soil between 13 high-As and 13 low-As plots managed by 16 different farmers, and we explore the implications for mitigation...
September 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28929318/monitoring-and-evaluating-the-ebola-response-effort-in-two-liberian-communities
#19
Davison Munodawafa, Matshidiso Rebecca Moeti, Peter Malekele Phori, Stephen B Fawcett, Ithar Hassaballa, Charles Sepers, Florence DiGennaro Reed, Jerry A Schultz, Ephraim Tafadzwa Chiriseri
Although credited with ultimately reducing incidence of Ebola Virus Disease (EVD) in West Africa, little is known about the amount and kind of Ebola response activities associated with reducing the incidence of EVD. Our team monitored Ebola response activities and associated effects in two rural counties in Liberia highly affected by Ebola. We used a participatory monitoring and evaluation system, and drew upon key informant interviews and document review, to systematically capture, code, characterize, and communicate patterns in Ebola response activities...
September 19, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28929127/risk-of-fungi-associated-with-aflatoxin-and-fumonisin-in-medicinal-herbal-products-in-the-kenyan-market
#20
Lucia Keter, Richard Too, Nicholas Mwikwabe, Charles Mutai, Jennifer Orwa, Lizzy Mwamburi, Stanley Ndwigah, Christine Bii, Richard Korir
Utilization of herbal products is a major concern due to the possibility of contamination by toxigenic fungi that are mycotoxin producers such as Aspergillus species during processing and packaging. Research was carried out to determine the presence of aflatoxins and fumonisins in herbal medicinal products sold in Eldoret and Mombasa towns in Kenya. The study employed both exploratory and laboratory experimental design. The herbal products were purchased from the market and transported to Kenya Medical Research Institute for processing and analysis...
2017: TheScientificWorldJournal
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