Eilise M Ryan, Pranvera Sadiku, Patricia Coelho, Emily R Watts, Ailiang Zhang, Andrew J M Howden, Manuel A Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H Dockrell, Moira K B Whyte, Sarah R Walmsley
RATIONALE: COPD (Chronic Obstructive Pulmonary Disease) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant responses and disease pathogenesis has yet to be fully delineated. OBJECTIVES: Through the study of COPD alveolar (AM) and peripheral monocyte-derived (MDM) macrophages, we sought to establish if intrinsic defects in core metabolic processes drive macrophage dysfunction and redox imbalance...
February 1, 2023: American Journal of Respiratory and Critical Care Medicine