keyword
MENU ▼
Read by QxMD icon Read
search

NadPH AND Parkinsons

keyword
https://www.readbyqxmd.com/read/27693730/menopause-and-parkinson-s-disease-interaction-between-estrogens-and-brain-renin-angiotensin-system-in-dopaminergic-degeneration
#1
REVIEW
Jose L Labandeira-Garcia, Ana I Rodriguez-Perez, Rita Valenzuela, Maria A Costa-Besada, Maria J Guerra
The neuroprotective effects of menopausal hormonal therapy in Parkinson's disease (PD) have not yet been clarified, and it is controversial whether there is a critical period for neuroprotection. Studies in animal models and clinical and epidemiological studies indicate that estrogens induce dopaminergic neuroprotection. Recent studies suggest that inhibition of the brain renin-angiotensin system (RAS) mediates the effects of estrogens in PD models. In the substantia nigra, ovariectomy induces a decrease in levels of estrogen receptor-α (ER-α) and increases angiotensin activity, NADPH-oxidase activity and expression of neuroinflammatory markers, which are regulated by estrogen replacement therapy...
October 2016: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/27610168/peganum-harmala-l-extract-reduces-oxidative-stress-and-improves-symptoms-in-6-hydroxydopamine-induced-parkinson-s-disease-in-rats
#2
Maryam Rezaei, Sima Nasri, Mehrdad Roughani, Zeinab Niknami, Seyed Ali Ziai
Parkinson's disease is one of the most common neurodegenerative disorders. There are many documents about the effects of oxidative stress in Parkinson's disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation. Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhibition and Parkinson's disease improvement. Male rats weighting 200-250 g were divided into 5 groups: Control, Neurotoxin (injection of 6-hydroxydopamine into left hemisphere substantia nigra), Peganum harmala's seeds aqueous extract (10 mg/kg) and captopril (5 mg/kg)...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27477685/redox-based-therapeutics-in-neurodegenerative-disease
#3
G J McBean, M G López, F K Wallner
This review describes recent developments in the search for effective therapeutic agents that target redox homeostasis in neurodegenerative disease. The disruption to thiol redox homeostasis in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and multiple sclerosis is discussed, together with the experimental strategies that are aimed at preventing, or at least minimising, oxidative damage in these diseases. Particular attention is given to the potential of increasing antioxidant capacity by targeting the Nrf2 pathway, the development of inhibitors of NADPH oxidases that are likely candidates for clinical usage, together with strategies to reduce nitrosative stress and mitochondrial dysfunction...
August 1, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27329107/identification-of-a-specific-%C3%AE-synuclein-peptide-%C3%AE-syn-29-40-capable-of-eliciting-microglial-superoxide-production-to-damage-dopaminergic-neurons
#4
Shijun Wang, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, Hui Nie, Wei Zhang, Belinda Wilson, Li Yang, Tessandra Stewart, Jau-Shyong Hong, Jing Zhang
BACKGROUND: Misfolded α-synuclein (α-Syn) aggregates participate in the pathogenesis of synucleinopathies, such as Parkinson's disease. Whereas much is known about how the various domains within full-length α-Syn (FL-α-Syn) contribute to the formation of α-Syn aggregates and therefore to their neurotoxicity, little is known about whether the individual peptides that can be generated from α-syn, possibly as intermediate metabolites during degradation of misfolded α-Syn aggregates, are neurotoxic themselves...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27184631/clozapine-metabolites-protect-dopaminergic-neurons-through-inhibition-of-microglial-nadph-oxidase
#5
Lulu Jiang, Xuefei Wu, Shuo Wang, Shih-Heng Chen, Hui Zhou, Belinda Wilson, Chun-Yang Jin, Ru-Band Lu, Keqin Xie, Qingshan Wang, Jau-Shyong Hong
BACKGROUND: Clozapine, an atypical antipsychotic medication, has been effectively used to treat refractory schizophrenia. However, the clinical usage of clozapine is limited due to a high incidence of neutropenia or agranulocytosis. We previously reported that clozapine protected dopaminergic neurons through inhibition of microglial activation. The purpose of this study was to explore the neuroprotective effects of clozapine metabolites clozapine N-oxide (CNO) and N-desmethylclozapine (NDC), as well as their propensity to cause neutropenia...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27002719/%C3%AE-mangostin-inhibits-%C3%AE-synuclein-induced-microglial-neuroinflammation-and-neurotoxicity
#6
Zhaoyang Hu, Wei Wang, Jing Ling, Chunming Jiang
Microglia-mediated neuroinflammation induced by α-synuclein in the substantianigra likely either initiates or aggravates nigral neuro degeneration in Parkinson's disease (PD). We aimed to explore the effects of α-mangostin (α-M), a polyphenolicxanthone derivative from mangosteen on α-synuclein-stimulated DA neurodegeneration. Primary microglia, mesencephalic neuron, mesencephalic neuron-glianeuronal cultures, and transwell co-cultures were prepared separately. Liquid scintillation counting was used to determine the radioactivity in DA uptake...
July 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/26960433/nadph-oxidase-promotes-parkinsonian-phenotypes-by-impairing-autophagic-flux-in-an-mtorc1-independent-fashion-in-a-cellular-model-of-parkinson-s-disease
#7
Rituraj Pal, Lakshya Bajaj, Jaiprakash Sharma, Michela Palmieri, Alberto Di Ronza, Parisa Lotfi, Arindam Chaudhury, Joel Neilson, Marco Sardiello, George G Rodney
Oxidative stress and aberrant accumulation of misfolded proteins in the cytosol are key pathological features associated with Parkinson's disease (PD). NADPH oxidase (Nox2) is upregulated in the pathogenesis of PD; however, the underlying mechanism(s) of Nox2-mediated oxidative stress in PD pathogenesis are still unknown. Using a rotenone-inducible cellular model of PD, we observed that a short exposure to rotenone (0.5 μM) resulted in impaired autophagic flux through activation of a Nox2 dependent Src/PI3K/Akt axis, with a consequent disruption of a Beclin1-VPS34 interaction that was independent of mTORC1 activity...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26957005/reciprocal-signals-between-microglia-and-neurons-regulate-%C3%AE-synuclein-secretion-by-exophagy-through-a-neuronal-cjun-n-terminal-kinase-signaling-axis
#8
Dan Ploug Christensen, Patrick Ejlerskov, Izabela Rasmussen, Frederik Vilhardt
BACKGROUND: Secretion of proteopathic α-synuclein (α-SNC) species from neurons is a suspected driving force in the propagation of Parkinson's disease (PD). We have previously implicated exophagy, the exocytosis of autophagosomes, as a dominant mechanism of α-SNC secretion in differentiated PC12 or SH-SY5Y nerve cells. Here we have examined the regulation of exophagy associated with different forms of nerve cell stress relevant to PD. RESULTS: We identify cJUN-N-terminal kinase (JNK) activity as pivotal in the secretory fate of autophagosomes containing α-SNC...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/26794209/neuroprotective-effects-of-dimerumic-acid-and-deferricoprogen-from-monascus-purpureus-ntu-568-fermented-rice-against-6-hydroxydopamine-induced-oxidative-stress-and-apoptosis-in-differentiated-pheochromocytoma-pc-12-cells
#9
Wei-Ting Tseng, Ya-Wen Hsu, Tzu-Ming Pan
Context Oxidative stress plays a key role in neurodegenerative disorders, including Parkinson's disease (PD). Rice fermented with Monascus purpureus Went (Monascaceae) NTU 568 (red mould rice) was found to contain antioxidants, including dimerumic acid (DMA) and deferricoprogen (DFC). Objective The effects of DMA and DFC on 6-hydroxydopamine (6-OHDA)-induced cytotoxicity and potential protective mechanisms in differentiated PC-12 pheochromocytoma cells were investigated. Materials and methods DMA (0-60 μM) or DFC (0-10 μM) was co-treated with 6-OHDA (200 μM, 24 h exposure) in differentiated PC-12 cells...
August 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/26394281/biochanin-a-protects-dopaminergic-neurons-against-lipopolysaccharide-induced-damage-and-oxidative-stress-in-a-rat-model-of-parkinson-s-disease
#10
Jun Wang, Can He, Wang-Yang Wu, Feng Chen, Yang-Yang Wu, Wei-Zu Li, Han-Qing Chen, Yan-Yan Yin
Parkinson's disease (PD) is the second most common neurodegenerative disease, which is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Accumulated evidences have suggested that oxidative stress is closely associated with the dopaminergic neurodegeneration of PD that can be protected by antioxidants. Biochanin A that is an O-methylated isoflavone in chickpea is investigated to explore its protective mechanism on dopaminergic neurons of the unilateral lipopolysaccharide (LPS)-injected rat...
November 2015: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/26370081/robust-glyoxalase-activity-of-hsp31-a-thij-dj-1-pfpi-family-member-protein-is-critical-for-oxidative-stress-resistance-in-saccharomyces-cerevisiae
#11
Kondalarao Bankapalli, SreeDivya Saladi, Sahezeel S Awadia, Arvind Vittal Goswami, Madhuja Samaddar, Patrick D'Silva
Methylglyoxal (MG) is a reactive metabolic intermediate generated during various cellular biochemical reactions, including glycolysis. The accumulation of MG indiscriminately modifies proteins, including important cellular antioxidant machinery, leading to severe oxidative stress, which is implicated in multiple neurodegenerative disorders, aging, and cardiac disorders. Although cells possess efficient glyoxalase systems for detoxification, their functions are largely dependent on the glutathione cofactor, the availability of which is self-limiting under oxidative stress...
October 30, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26367469/apocyanin-nadph-oxidase-inhibitor-prevents-lipopolysaccharide-induced-%C3%AE-synuclein-aggregation-and-ameliorates-motor-function-deficits-in-rats-possible-role-of-biochemical-and-inflammatory-alterations
#12
Neha Sharma, Monika Kapoor, Bimla Nehru
Parkinson's disease (PD), is an age-related, progressive neurodegenerative disorder that affects movement and is characterized by the loss of dopaminergic neurons in the nigrostriatal region. Although the clinical and pathological features of PD are complex, recent studies have indicated that microglial NADPH oxidase play a key role in its pathology. A little information is available regarding the role of apocyanin, an NADPH oxidase inhibitor, in ameliorating α-synuclein aggregation and neurobehavioral consequences of PD...
January 1, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26352497/effects-of-aging-on-nitrergic-neurons-in-human-striatum-and-subthalamic-nucleus
#13
Bruno Lopes dos Santos-Lobato, Elaine Aparecida Del-Bel, José Eymard Homem Pittella, Vitor Tumas
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson's disease, are more prevalent on aged individuals. We investigated the effects of aging on neuronal density and diameter/area of nitrergic neurons in samples of striatum (caudate and putamen) and subthalamic nucleus of 20 human brains from normal subjects, stained by histochemistry for NADPH-diaphorase and immunohistochemistry for neuronal NO synthase. Our data showed aging does not modify the neuronal density and size of nitrergic neurons in striatum and subthalamic nucleus...
September 2015: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/26267055/nadph-oxidase-mediated-maneb-and-paraquat-induced-oxidative-stress-in-rat-polymorphs-crosstalk-with-mitochondrial-dysfunction
#14
Smriti Shukla, Deepali Singh, Vinod Kumar, Amit Kumar Chauhan, Shweta Singh, Israr Ahmad, Haushila Prasad Pandey, Chetna Singh
Oxidative stress is a key factor in Parkinson's disease (PD) pathogenesis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and impaired mitochondrion regulate oxidative stress-mediated maneb (MB)- and paraquat (PQ)-induced Parkinsonism. However, their contribution in the MB- and PQ-induced toxicity in polymorphonuclear leukocytes (PMNs) is still elusive. The study investigated the role of NADPH oxidase and mitochondria in MB- and/or PQ-induced oxidative stress in the PMNs and the crossing point between the two...
September 2015: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/26211726/6-hydroxydopamine-as-a-tool-to-understand-adaptive-immune-system-induced-dopamine-neurodegeneration-in-parkinson-s-disease
#15
Shaji Theodore, William Maragos
CONTEXT: Neuroimmunological response is associated with neurodegeneration in the human substantia nigra (SN) in Parkinson's disease (PD). OBJECTIVE: To explore the possibility that the neurotoxin, 6-hydroxydopamine (6-OHDA), could be used as a tool in mice to understand the immune response in PD. MATERIALS AND METHODS: We employed unilateral administration of 6-OHDA into the mouse SN. At 1 week, 2 weeks and 4 weeks post-injection, we used immunohistochemistry for the markers Iba-1 and gp91PHOX to investigate activated microglia in the SN...
2015: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/26186897/impact-of-anesthetic-regimen-on-the-respiratory-pattern-eeg-microstructure-and-sleep-in-the-rat-model-of-cholinergic-parkinson-s-disease-neuropathology
#16
COMPARATIVE STUDY
K Lazic, J Petrovic, J Ciric, A Kalauzi, J Saponjic
OBJECTIVES: We hypothesized that the impact of distinct anesthetic regimens could be differently expressed during anesthesia and on post-anesthesia sleep in the neurodegenerative diseases. Therefore, we followed the impact of ketamine/diazepam and pentobarbital anesthesia in a rat model of the severe Parkinson's disease cholinergic neuropathology on the electroencephalographic (EEG) microstructure and respiratory pattern during anesthesia, and on the post-anesthesia sleep. METHODS: We performed the experiments on adult, male, spontaneously breathing Wistar rats chronically instrumented for sleep recording...
September 24, 2015: Neuroscience
https://www.readbyqxmd.com/read/26135009/further-characterization-of-the-metabolism-of-desloratadine-and-its-cytochrome-p450-and-udp-glucuronosyltransferase-inhibition-potential-identification-of-desloratadine-as-a-relatively-selective-ugt2b10-inhibitor
#17
Faraz Kazmi, Phyllis Yerino, Joanna E Barbara, Andrew Parkinson
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating antihistamine used for the treatment of seasonal allergies and hives. Previously we reported that the formation of 3-hydroxydesloratadine, the major human metabolite of desloratadine, involves three sequential reactions, namely N-glucuronidation by UGT2B10 followed by 3-hydroxylation by CYP2C8 followed by deconjugation (rapid, nonenzymatic hydrolysis of the N-glucuronide). In this study we assessed the perpetrator potential of desloratadine based on in vitro studies of its inhibitory effects on cytochrome P450 and UDP-glucuronosyltransferase (UGT) enzymes in human liver microsomes (HLM)...
September 2015: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/26081143/apocyanin-a-microglial-nadph-oxidase-inhibitor-prevents-dopaminergic-neuronal-degeneration-in-lipopolysaccharide-induced-parkinson-s-disease-model
#18
Neha Sharma, Bimla Nehru
Microglia-associated inflammatory processes have been strongly implicated in the development and progression of Parkinson's disease (PD). Specifically, microglia are activated in response to lipopolysaccharide (LPS) and become chronic source of cytokines and reactive oxygen species (ROS) production. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex is responsible for extracellular as well as intracellular production of ROS by microglia and its expression is upregulated in PD. Therefore, targeting NADPH oxidase complex activation using an NADPH oxidase inhibitor, i...
July 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26055970/characterization-of-the-lipopolysaccharide-induced-model-of-parkinson-s-disease-role-of-oxidative-stress-and-neuroinflammation
#19
Neha Sharma, Bimla Nehru
INTRODUCTION: Primary pathology underlying Parkinson's disease (PD) is the loss of dopaminergic neurons in the substantia nigra (SN). A variety of genetic and environmental factors underlie this loss of dopaminergic neurons. However, recent studies have highlighted the role of elevated oxidative stress and the pro-inflammatory responses contributing to or exacerbating the nigrostriatal degeneration. METHODS: With the establishment of neuroinflammation as an important process involved in the PD pathogenesis, in the present study this pathogenic feature was replicated in animals using lipopolysaccharide (LPS) (5 ug/5 ul PBS) infused stereotaxically into the SN of rats...
August 2015: Neurochemistry International
https://www.readbyqxmd.com/read/26021615/park7-interacts-with-p47-phox-to-direct-nadph-oxidase-dependent-ros-production-and-protect-against-sepsis
#20
Wenjun Liu, Hailong Wu, Lili Chen, Yankai Wen, Xiaoni Kong, Wei-Qiang Gao
Inappropriate inflammation responses contribute to mortality during sepsis. Through Toll-like receptors (TLRs), reactive oxygen species (ROS) produced by NADPH oxidase could modulate the inflammation responses. Parkinson disease (autosomal recessive, early onset) 7 (Park7) has a cytoprotective role by eliminating ROS. However, whether Park7 could modulate inflammation responses and mortality in sepsis is unclear. Here, we show that, compared with wild-type mice, Park7(-/-) mice had significantly increased mortality and bacterial burdens in sepsis model along with markedly decreased systemic and local inflammation, and drastically impaired macrophage phagocytosis and bacterial killing abilities...
June 2015: Cell Research
keyword
keyword
108665
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"