keyword
https://read.qxmd.com/read/38536791/intrauterine-and-early-life-malnutrition-in-rats-disrupts-the-circadian-rhythm-programming-of-energy-metabolites-through-adulthood
#1
JOURNAL ARTICLE
Dulce Jocelyn Bustamante-Valdez, Martin Alejandro Fuentes-Cano, Jesus Salvador Gonzalez-Ruano, Alonso Martinez-Canabal, Rene Cardenas-Vazquez, Pilar Duran
Maternal malnutrition plays a crucial role in functional development, resulting in behavioral, cognitive, and metabolic abnormalities and disturbances. "Cafeteria diet" has been linked to obesity, metabolic syndrome, diabetes, and other metabolic disruptions in the mammalian lifespan. However, there are very few reports about the effect of intrauterine and early postnatal malnutrition on the circadian rhythm programming of energy metabolites. In mammals, circadian rhythm central control is fundamental for correct interaction with the environment and physiological regulation...
2024: PloS One
https://read.qxmd.com/read/38528508/triglyceride-glucose-index-in-early-pregnancy-predicts-the-risk-of-gestational-diabetes-a-prospective-cohort-study
#2
JOURNAL ARTICLE
Yufeng Guo, Junwen Lu, Mailiman Bahani, Guifeng Ding, Lei Wang, Yuxia Zhang, Huanmei Zhang, Chengyao Liu, Lijun Zhou, Xiaolan Liu, Fangshen Li, Xiaoli Wang, Hong Ding
OBJECTIVE: This study aimed to investigate the association between the triglyceride-glucose (TyG) index in early pregnancy and the development of gestational diabetes mellitus (GDM) in the second trimester. The primary objectives were to evaluate the predictive potential of the TyG index for GDM, determine the optimal threshold value of the TyG index for GDM assessment, and compare the predictive performance of the TyG index alone versus its combination with maternal age and pre-pregnancy body mass index on GDM...
March 25, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38524205/gestational-diabetes-mellitus-in-pregnancies-conceived-after-infertility-treatment-a-population-based-study-in-the-united-states-2015-2020
#3
JOURNAL ARTICLE
Devika Sachdev, Mark V Sauer, Cande V Ananth
OBJECTIVE: To evaluate the risk of gestational diabetes mellitus (GDM) in singleton pregnancies conceived using infertility treatment and examine the influence of race and ethnicity as well as prepregnancy body mass index (BMI). DESIGN: Cross-sectional study using the US vital records data of women that delivered singleton births. SETTING: United States, 2015-2020. INTERVENTIONS: Any infertility treatment was divided into two groups: those that used fertility-enhancing drugs, artificial insemination, or intrauterine insemination, and those that used assisted reproductive technology (ART)...
March 2024: F&S reports
https://read.qxmd.com/read/38523364/association-between-hyperglycemia-during-pregnancy-and-offspring-s-refractive-error-a-focused-review
#4
REVIEW
Yufan Guo, Jingru Lu, Linlin Zhu, Xuemei Hao, Kun Huang
This review article explores the relationship between hyperglycemia during pregnancy and the visual development of offspring, specifically focusing on refractive error. The authors conducted a comprehensive search for relevant articles in various databases and assessed the methodological quality of the included studies. The findings consistently indicate that hyperglycemia during pregnancy can have a detrimental impact on the structural and functional aspects of visual development in offspring. The intrauterine hyperglycemic environment appears to negatively affect the retina and lens, leading to refractive errors...
March 24, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38520760/the-impact-of-the-covid-19-pandemic-on-infant-obesity-a-nationwide-retrospective-cohort-study
#5
JOURNAL ARTICLE
Hye Jin Han, Joohyun Woo, Won Young Wi, Kyu-Dong Cho, Minji Koo, Su Jung Hong, Young Mi Jung, Ho Yeon Kim, Ki Hoon Ahn, Soon-Cheol Hong, Hai-Joong Kim, Min-Jeong Oh, Geum Joon Cho
BACKGROUND: Lifestyle changes, such as those related to the COVID-19 pandemic, including alterations in physical activity and dietary habits, are known to affect pregnancy outcomes. In particular, suboptimal intrauterine conditions during pregnancy are known to influence not only fetal growth but also growth during infancy. However, research on the impact of the environmental changes caused by the COVID-19 pandemic on the growth of infants and children during their early years is lacking...
March 13, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38505753/reprogramming-of-the-developing-heart-by-hif1a-deficient-sympathetic-system-and-maternal-diabetes-exposure
#6
JOURNAL ARTICLE
Hana Kolesova, Petra Hrabalova, Romana Bohuslavova, Pavel Abaffy, Valeria Fabriciova, David Sedmera, Gabriela Pavlinkova
INTRODUCTION: Maternal diabetes is a recognized risk factor for both short-term and long-term complications in offspring. Beyond the direct teratogenicity of maternal diabetes, the intrauterine environment can influence the offspring's cardiovascular health. Abnormalities in the cardiac sympathetic system are implicated in conditions such as sudden infant death syndrome, cardiac arrhythmic death, heart failure, and certain congenital heart defects in children from diabetic pregnancies...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38502240/no-association-between-long-chain-n-3-fatty-acid-intake-during-pregnancy-and-risk-of-type-1-diabetes-in-offspring-in-two-large-scandinavian-pregnancy-cohorts
#7
JOURNAL ARTICLE
Nicolai A Lund-Blix, Anne A Bjerregaard, German Tapia, Ketil Størdal, Anne Lise Brantsæter, Marin Strøm, Thorhallur I Halldorsson, Charlotta Granstrøm, Jannet Svensson, Geir Joner, Torild Skrivarhaug, Pål R Njølstad, Sjurdur F Olsen, Lars C Stene
AIMS/HYPOTHESIS: The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children. METHODS: The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires...
March 19, 2024: Diabetologia
https://read.qxmd.com/read/38495346/cell%C3%A2-free-fetal-dna-at%C3%A2-11%C3%A2-13%C3%A2-weeks-of-gestation-is-not-altered-in-complicated-pregnancies
#8
JOURNAL ARTICLE
Zoi Koukou, Eleftherios Panteris, Emmanouel Manolakos, Aristeidis Papadopoulos, Ioannis Papoulidis, Konstantinos Relakis, Stavros Sifakis
Non-invasive maternal cell-free fetal DNA (cffDNA) is a promising biomarker for screening common genetic syndromes. Alterations in the expression levels of cffDNA in the maternal circulation have been demonstrated in abnormal pregnancies. However, the results are conflicting. The present study aimed to investigate whether cffDNA levels are associated with pregnancy complications. The study group comprised pregnant women who presented with pregnancy complications, such as preterm birth, gestational hypertension, intrauterine growth retardation, gestational diabetes, polyhydramnios, oligohydramnios, vaginal bleeding and placental abruption...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38491313/appropriate-glycemic-management-protects-the-germline-but-not-the-uterine-environment-in-hyperglycemia
#9
JOURNAL ARTICLE
Allan Zhao, Hong Jiang, Arturo Reyes Palomares, Alice Larsson, Wenteng He, Jacob Grünler, Xiaowei Zheng, Kenny A Rodriguez Wallberg, Sergiu-Bogdan Catrina, Qiaolin Deng
Emerging evidence indicates that parental diseases can impact the health of subsequent generations through epigenetic inheritance. Recently, it was shown that maternal diabetes alters the metaphase II oocyte transcriptome, causing metabolic dysfunction in offspring. However, type 1 diabetes (T1D) mouse models frequently utilized in previous studies may be subject to several confounding factors due to severe hyperglycemia. This limits clinical translatability given improvements in glycemic control for T1D subjects...
March 15, 2024: EMBO Reports
https://read.qxmd.com/read/38479548/maternal-exercise-preserves-offspring-cardiovascular-health-via-oxidative-regulation-of-the-ryanodine-receptor
#10
JOURNAL ARTICLE
Kelsey M Pinckard, Elisa Félix-Soriano, Shanna Hamilton, Radmila Terentyeva, Lisa A Baer, Katherine R Wright, Drew Nassal, Joao Victor Esteves, Eaman Abay, Vikram K Shettigar, Mark T Ziolo, Thomas J Hund, Loren E Wold, Dmitry Terentyev, Kristin I Stanford
OBJECTIVE: The intrauterine environment during pregnancy is a critical factor in the development of obesity, diabetes, and cardiovascular disease in offspring. Maternal exercise prevents the detrimental effects of a maternal high fat diet on the metabolic health in adult offspring, but the effects of maternal exercise on offspring cardiovascular health have not been thoroughly investigated. METHODS: To determine the effects of maternal exercise on offspring cardiovascular health, female mice were fed a chow (C; 21% kcal from fat) or high-fat (H; 60% kcal from fat) diet and further subdivided into sedentary (CS, HS) or wheel exercised (CW, HW) prior to pregnancy and throughout gestation...
March 11, 2024: Molecular Metabolism
https://read.qxmd.com/read/38470452/sex-specific-alterations-in-placental-proteomics-induced-by-intrauterine-hyperglycemia
#11
JOURNAL ARTICLE
Zhuo-Ran Ren, Si-Si Luo, Xue-Yun Qin, He-Feng Huang, Guo-Lian Ding
Gestational diabetes mellitus (GDM) with intrauterine hyperglycemia induces a series of changes in the placenta, which have adverse effects on both the mother and the fetus. The aim of this study was to investigate the changes in the placenta in GDM and its gender differences. In this study, we established an intrauterine hyperglycemia model using ICR mice. We collected placental specimens from mice before birth for histological observation, along with tandem mass tag (TMT)-labeled proteomic analysis, which was stratified by sex...
March 12, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38454339/the-impact-of-first-trimester-subchorionic-hematomas-on-pregnancy-outcomes-after-euploid-embryo-transfer-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Weilin Wang, Qing Zhao, Yingbo Liu, Ling Guo, Wei Zhou, Qian Zhang, Junhao Yan, Tianxiang Ni
BACKGROUND: The aim of the retrospective cohort study was to investigate the prognostic effect of subchorionic hematomas (SCH) in the first trimester on pregnancy outcomes after euploid embryo transfer. METHODS: We retrospectively analyzed women achieving singleton pregnancy by PGT-A or PGT-SR from January 2017 to January 2022. Patients were enrolled in the study if they had a viable intrauterine pregnancy at ultrasound between 6 0/7 and 8 0/7 weeks of gestation...
March 7, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38451874/peroxisome-proliferator-activated-receptors-and-placental-function-in-women-with-polycystic-ovary-syndrome
#13
REVIEW
Aimé Silva, Alicia Motta
Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders affecting women during their reproductive ages. Given its association with other pathologies, such as insulin resistance, metabolic syndrome, type 2 diabetes and obesity, women with PCOS could present high-risk pregnancies, including a high abortion rate, implantation failure, an increased risk of gestational diabetes, preeclampsia, and intrauterine growth restriction. These adverse pregnancy outcomes are often attributed, at least in part, to defects in placental functions...
March 1, 2024: Reproduction
https://read.qxmd.com/read/38445471/abnormal-umbilical-cord-coiling-and-association-with-pregnancy-factors
#14
JOURNAL ARTICLE
Pavan Kumar Reddy Kalluru, Haritha Reddy Kalluru, Teja Reddy Allagadda, Mouna Talur, Manna Charlotte Gonepogu, Shalu Gupta
The umbilical cord, as a connecting bridge between two lives, plays an important role in fetal development. Though studies on the umbilical cord date back many years, extensive studies on certain umbilical cord characteristics, such as umbilical cord coiling, are rare. Cord coiling, measured by the umbilical coiling index, is a physiological phenomenon that offers resistance to external pressures. Umbilical cord coiling is a result of several factors, both environmental and genetic. However, umbilical cords sometimes coil abnormally, resulting in hypocoiling, hypercoiling, or non-coiling which have significant associations with adverse perinatal outcomes...
March 6, 2024: Journal of the Turkish German Gynecological Association
https://read.qxmd.com/read/38440108/maternal-obesity-modulates-cord-blood-concentrations-of-proprotein-convertase-subtilisin-kexin-type-9-levels
#15
JOURNAL ARTICLE
Dimitrios Rallis, Aimilia Eirini Papathanasiou, Helen Christou
CONTEXT: In utero exposure to maternal obesity or diabetes is considered a pro-inflammatory state. OBJECTIVE: To evaluate whether cord blood proprotein convertase subtilisin/kexin-type 9 (PCSK9), which is regulated by inflammation and metabolic derangements, is elevated in neonates born to overweight, obese, or diabetic mothers. METHODS: A retrospective study in full-term neonates born between 2010 and 2023, at Brigham and Women's Hospital...
February 19, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38438886/autoimmune-diseases-and-adverse-pregnancy-outcomes-an-umbrella-review
#16
JOURNAL ARTICLE
Megha Singh, Steven Wambua, Siang Ing Lee, Kelvin Okoth, Zhaonan Wang, Fathima Fazla Ahamed Fayaz, Kelly-Ann Eastwood, Catherine Nelson-Piercy, John A Reynolds, Krishnarajah Nirantharakumar, Francesca Crowe
BACKGROUND: There is a high prevalence of autoimmune conditions in women specially in the reproductive years; thus, the association with adverse pregnancy outcomes has been widely studied. However, few autoimmune conditions/adverse outcomes have been studied more than others, and this umbrella review aims to consolidate existing knowledge in this area with the aim to provide new knowledge and also identify gaps in this research area. METHODS: Medline, Embase, and Cochrane databases were searched from inception to December 2023...
March 5, 2024: BMC Medicine
https://read.qxmd.com/read/38421160/interaction-effect-between-low-birthweight-and-resistin-gene-rs1862513-variant-on-insulin-resistance-and-type%C3%A2-2-diabetes-mellitus-in-adulthood-toon-genome-study
#17
JOURNAL ARTICLE
Ayaka Yoshida, Yasunori Takata, Yasuharu Tabara, Koutatsu Maruyama, Shota Inoue, Haruhiko Osawa, Takashi Sugiyama
AIMS/INTRODUCTION: Gene-environment interactions are considered to critically influence type 2 diabetes mellitus development; however, the underlying mechanisms and specific interactions remain unclear. Given the increasing prevalence of low birthweight (LBW) influenced by the intrauterine environment, we sought to investigate genetic factors related to type 2 diabetes development in individuals with LBW. MATERIALS AND METHODS: The interaction between 20 reported type 2 diabetes susceptibility genes and the development of type 2 diabetes in LBW (<2,500 g) individuals in a population-based Japanese cohort (n = 1,021) was examined by logistic regression and stratified analyses...
February 29, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38406574/folic-acid-the-key-to-a-healthy-pregnancy-a-prospective-study-on-fetomaternal-outcome
#18
JOURNAL ARTICLE
Madhusudan Dey, Pranjali Dhume, Sanjay K Sharma, Suyash Goel, Sunil Chawla, Ankur Shah, G Madhumidha, Reshu Rawal
OBJECTIVES: The objective of the study is to study the fetomaternal outcome associated with folic acid deficiency in pregnancy. MATERIALS AND METHODS: This hospital-based observational study was conducted in the Department of Obstetrics and Gynaecology at Base Hospital, Delhi Cantt, and a total of 351 participants were enrolled who were fulfilling the inclusion criteria. The plasma folic acid level of the selected patients was measured in the booking visit by automated chemiluminescence assay...
2024: Tzu chi medical journal
https://read.qxmd.com/read/38397953/diabetes-mellitus-and-pregnancy-an-insight-into-the-effects-on-the-epigenome
#19
REVIEW
Andrea Meza-León, Araceli Montoya-Estrada, Enrique Reyes-Muñoz, José Romo-Yáñez
Worldwide, diabetes mellitus represents a growing health problem. If it occurs during pregnancy, it can increase the risk of various abnormalities in early and advanced life stages of exposed individuals due to fetal programming occurring in utero. Studies have determined that maternal conditions interfere with the genotypes and phenotypes of offspring. Researchers are now uncovering the mechanisms by which epigenetic alterations caused by diabetes affect the expression of genes and, therefore, the development of various diseases...
February 2, 2024: Biomedicines
https://read.qxmd.com/read/38397682/does-intrauterine-exposure-to-diabetes-impact-mental-and-motor-skills-a-meta-analysis-of-the-bayley-scales-of-infant-development
#20
REVIEW
Diana Arabiat, Mohammad Al Jabery, Lisa Whitehead
BACKGROUND: Attempts to conduct meta-analyses of the association between child development and diabetes have been limited by the wide range of tools and definitions of developmental outcomes used in the literature. We aim to meta-analyze a widely used measure of child development, the Bayley Scales of Infant Development, with respect to exposure to diabetes and developmental scores. METHODS: PsycINFO, MEDLINE/PubMed, EMBASE, Emcare, and Google Scholar databases were searched...
February 7, 2024: International Journal of Environmental Research and Public Health
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