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Intrauterine diabetes

João Paulo de Castro Marcondes, Pablo Felipe Bertolini Andrade, André Luiz Ventura Sávio, Maruhen Amir Datsch Silveira, Marilza Vieira Cunha Rudge, Daisy Maria Fávero Salvadori
Several findings suggest that in utero stressor stimuli can alter fetal development by promoting transcriptional changes, and predisposing the neonate to diseases later in life. This study aimed to investigate whether a hyperglycemic environment in pregnant women with gestational diabetes mellitus (GDM) is able to cause fetal genetic alterations and predispose neonates to obesity. Transcriptional alteration of SIRT1, TP53 and BCL2 genes, miR-181a (a SIRT1 or BCL2 regulator) and telomere length were evaluated in placental and umbilical-cord blood cells...
December 2018: Mutation Research
Y Q Lee, C E Collins, A Gordon, K M Rae, K G Pringle
Evidence from animal models indicates that exposure to an obesogenic or hyperglycemic intrauterine environment adversely impacts offspring kidney development and renal function. However, evidence from human studies has not been evaluated systematically. Therefore, the aim of this systematic review was to synthesize current research in humans that has examined the relationship between gestational obesity and/or diabetes and offspring kidney structure and function. Systematic electronic database searches were conducted of five relevant databases (CINAHL, Cochrane, EMBASE, MEDLINE and Scopus)...
November 9, 2018: Journal of Developmental Origins of Health and Disease
Judith S Brand, Jane West, Derek Tuffnell, Philippa K Bird, John Wright, Kate Tilling, Debbie A Lawlor
BACKGROUND: Maternal gestational diabetes (GDM) is an established risk factor for large size at birth, but its influence on intrauterine fetal growth in different ethnic populations is less well understood. Here, we examine the joint associations of GDM and ethnicity with longitudinal fetal growth in South Asian and White European origin women. METHODS: This study included 10,705 singletons (4747 White European and 5958 South Asian) from a prospective cohort of women attending an antenatal clinic in Bradford, in the North of England...
November 6, 2018: BMC Medicine
Eileen Hwuang, Marta Vidorreta, Nadav Schwartz, Brianna F Moon, Kirpal Kochar, Matthew Dylan Tisdall, John A Detre, Walter R T Witschey
BACKGROUND: Uterine artery (UtA) hemodynamics might be used to predict risk of hypertensive pregnancy disorders, including preeclampsia and intrauterine growth restriction. PURPOSE OR HYPOTHESIS: To determine the feasibility of 4D flow MRI in pregnant subjects by characterizing UtA anatomy, computing UtA flow, and comparing UtA velocity, and pulsatility and resistivity indices (PI, RI) with transabdominal Doppler ultrasound (US). STUDY TYPE: Prospective cross-sectional study from June 6, 2016, to May 2, 2018...
November 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
Wei Ye, Tongqiang Zhang, Yang Shu, Chengzhi Fang, Lili Xie, Kaiwei Peng, Chunmei Liu
OBJECTIVE: To explore the relevant influencing factors of neonatal respiratory distress syndrome (NRDS) in southern China and provide scientific basis for improving the quality of life for neonates. METHODS: A retrospective analysis of 320 cases with NRDS neonates admitted from January 2015 to December 2017 in a neonatal department of a Maternal and Child Health Hospital in South China was conducted. Three hundred twenty non-NRDS patients admitted to the same hospital during the same period were also included as control...
October 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
Amanda R Sergesketter, Aladine A Elsamadicy, David T Lubkin, Kate B Krucoff, Max O Krucoff, Carrie R Muh
BACKGROUND: Certain intrauterine risk factors are known to increase the risk of premature cranial suture fusion and may cause complications during birth. Some of these risk factors may be modifiable. Therefore, the authors sought to characterize the institutional patterns of prenatal risk factors and perinatal complications in nonsyndromic craniosynostosis patients compared to normal births from the surrounding area to identify areas for possible intervention or prevention. METHODS: The medical records of all infants with nonsyndromic craniosynostosis and full birth records born at Duke University Health System from 2006 to 2017 were retrospectively reviewed...
October 24, 2018: Journal of Craniofacial Surgery
Ekaterina Maslova, Susanne Hansen, Marin Strøm, Thorhallur I Halldorsson, Louise G Grunnet, Allan A Vaag, Sjurdur F Olsen
Oily fish, an important source of marine n-3 long-chain polyunsaturated fatty acids (LCPUFA), has shown to reduce cardiometabolic risk in adults. Whether maternal fish intake affects offspring metabolic health is less established, especially among high-risk pregnancies. We aimed to examine the association of fish intake in pregnancy with offspring metabolic health who were either exposed or unexposed to gestational diabetes mellitus (GDM). Our study included 1234 mother-offspring dyads (608 with a GDM index pregnancy and 626 control dyads) nested within the Danish National Birth Cohort, which is a prebirth cohort...
October 17, 2018: Nutrients
Asako Kumagai, Atsuo Itakura, Daisuke Koya, Keizo Kanasaki
Although the global maternal mortality ratio has been consistently reduced over time, in 2015, there were still 303,000 maternal deaths throughout the world, of which 99% occurred in developing countries. Understanding pathophysiology of pregnancy complications contributes to the proper prenatal care for the reduction of prenatal, perinatal and neonatal mortality and morbidity ratio. In this review, we focus on AMP-activated protein kinase (AMPK) as a regulator of pregnancy complications. AMPK is a serine/threonine kinase that is conserved within eukaryotes...
October 9, 2018: International Journal of Molecular Sciences
Abir El Sadik, Enas Mohamed, Ahmed El Zainy
Development and maturation of submandibular salivary glands are influenced by intrauterine diabetic environment. Several studies investigated the effects of diabetes on the salivary glands. However, the effects of maternal diabetes on the submandibular glands of the offspring was not properly examined. Therefore, the present study was designed to describe the changes in the development of the submandibular glands of the offspring of diabetic mothers. The submandibular glands of the offspring of Streptozotocin (STZ)-induced diabetic female rats were examined at two and four weeks after birth...
2018: PloS One
Brian Akhaphong, Amber Lockridge, Seokwon Jo, Ramkumar Mohan, Jacob A Wilcox, Cameron R Wing, Jean F Regal, Emilyn U Alejandro
Maternal hypertension during pregnancy is a major risk factor for intrauterine growth restriction (IUGR), which increases susceptibility to cardiovascular and metabolic disease in adulthood through unclear mechanisms. The aim of this study was to characterize pancreatic beta cell area and function in the fetal rat offspring of reduced uterine perfusion pressure (RUPP) model of gestational hypertension. At embryonic day 19.5, RUPP dams exhibited lower body weight, elevated mean blood pressure, reduced litter size, and higher blood glucose compared to sham-operated controls...
October 10, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Emma C Johns, Fiona C Denison, Jane E Norman, Rebecca M Reynolds
Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy. The prevalence is rising and correlates with the increase in maternal obesity over recent decades. The etiology of GDM is complex, with genetic and environmental factors implicated in mechanistic and epidemiological studies. GDM begets important short- and long-term health risks for the mother, developing fetus, and offspring. This includes the high likelihood of subsequent maternal type 2 diabetes (T2DM), and possible adverse cardiometabolic phenotypes in the offspring...
November 2018: Trends in Endocrinology and Metabolism: TEM
Corina Lesseur, Jia Chen
PURPOSE OF REVIEW: Herein, we summarize existent epidemiological studies relating adverse maternal metabolic environments of maternal obesity and gestational diabetes and placental DNA methylation. RECENT FINDINGS: Multiple studies have evaluated associations between intrauterine exposure to gestational diabetes and/or maternal glucose levels and DNA methylation at candidate metabolic genes as well as in epigenome-wide studies. Some of the genomic regions more consistently associated include lipid-related genes (LPL and PPARGC1A), the major histocompatibility complex (MHC), and imprinted genes...
September 28, 2018: Current Environmental Health Reports
Yingmin Wang, Weifen Zhu, Lianhui Chen, Li Liang
BACKGROUND: Small for gestational age (SGA) due to intrauterine malnourishment is closely related to metabolic syndrome and type 2 diabetes mellitus. Growth Hormone (GH) treatment has been demonstrated to influence metabolic parameters and islet function of SGA individuals. The present study demonstrates the effects of early GH treatment on glucose tolerance and expression of pancreatic duodenal homeobox 1 (Pdx1) of SGA rats during adulthood METHODS: SGA rat model was induced by restricting food intake during pregnancy...
September 26, 2018: Experimental and Clinical Endocrinology & Diabetes
A O Netto, R B Gelaleti, S B Corvino, R G Serrano, S C Hernández, G T Volpato, M V C Rudge, M G Braz, D C Damasceno
Fetal impairment caused by a deleterious intrauterine environment may have long-term consequences, such as oxidative stress and genetic damage. Rats born as small-for-gestational-age (SPA) were submitted to exercise (swimming) before and during pregnancy. The animals exhibited glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight, showing the benefit of exercise for these rats. We hypothesised that regular exercise in SPA during gestation could prevent DNA damage in these animals and in their offspring, contributing to altered fetal programming of metabolism in the offspring...
November 2018: Mutation Research
Linda A Barbour, Teri L Hernandez
There is increasing recognition that maternal glucose concentrations lower than those previously used for diagnosis of gestational diabetes mellitus (GDM) and targeted for treatment can result in excess fetal growth. Yet, mothers with GDM who appear to have optimal glycemic control and mothers with obesity and normal glucose tolerance still have a significantly increased risk for delivering infants who are large for gestational age, or even more importantly, who have increased adiposity at birth. What is less appreciated is that in addition to glucose, maternal lipids are also substrates for fetal fat accretion and that placental lipases can hydrolyze maternal triglycerides (TGs) to free fatty acids for fetal-placental availability...
October 2018: Clinical Therapeutics
Anitha Pitchika, Kendra Vehik, Sandra Hummel, Jill M Norris, Ulla M Uusitalo, Jimin Yang, Suvi M Virtanen, Sibylle Koletzko, Carin Andrén Aronsson, Anette-G Ziegler, Andreas Beyerlein
OBJECTIVE: This study aimed to determine the relationship between different forms of, and potential pathways between, maternal diabetes and childhood obesity at different ages. METHODS: Prospective cohort data from The Environmental Determinants of Diabetes in the Young (TEDDY) study, which was composed of 5,324 children examined from 0.25 to 6 years of age, were analyzed. Cross-sectional and longitudinal analyses taking into account potential confounders and effect modifiers such as maternal prepregnancy BMI and birth weight z scores were performed...
September 2018: Obesity
Alexander J Garner, Annette Robertson, Charlene Thornton, Gaksoo Lee, Angela Makris, Sally Middleton, Colin Sullivan, Annemarie Hennessy
Objective: To compare perinatal outcomes, blood pressures throughout pregnancy, rates of hypertensive disorders of pregnancy, preeclampsia, gestational diabetes mellitus, and immediate obstetric outcomes in adolescents younger than 20 years at delivery and those in the 20- to 34-year age group. Patients and Methods: Questionnaires were administered to pregnant women at Campbelltown and Liverpool hospitals within South West Sydney, Australia, as part of a broader study of sleep-disordered breathing in pregnancy between February 1, 2009, and February 28, 2013...
March 2018: Mayo Clinic proceedings. Innovations, quality & outcomes
Daniel Musikant, Hugo Sato, Evangelina Capobianco, Verónica White, Alicia Jawerbaum, Romina Higa
Maternal diabetes programs cardiovascular alterations in the adult offspring but the mechanisms involved remain unclarified. Here, we addresed whether maternal diabetes programs cardiac alterations related to extracellular matrix remodeling in the adult offspring, as well as the role of forkhead box transcription factor 1 (FOXO1) in the induction of these alterations. The heart from adult offspring from control and streptozotocin-induced diabetic rats was evaluated. Increased glycemia, triglyceridemia and insulinemia and markers of cardiomyopathy were found in the offspring from diabetic rats...
September 11, 2018: Molecular and Cellular Endocrinology
Mette Østergaard Thunbo, Marianne Sinding, Pauline Bogaard, Anne Sofie Korsager, Jens Brøndum Frøkjær, Lasse Riis Østergaard, Astrid Petersen, Anne Sørensen
INTRODUCTION: Pregnancy complicated by diabetes mellitus (DM) is a central obstetric problem often complicated by fetal macrosomia and increased risk of intrapartum asphyxia. This risk might be explained by fetoplacental vascular abnormalities. This study aimed to investigate the fetoplacental vascular volume by placental CT angiography in normal pregnancies and in pregnancies complicated by type 1 DM (T1DM), diet controlled gestational DM (GDMd), and insulin treated gestational DM (GDMi)...
September 2018: Placenta
Whitney Bender, Adi Hirshberg, Lisa D Levine
OBJECTIVE:  To examine the change in body mass index (BMI) categories between pregnancies and its effect on adverse pregnancy outcomes. STUDY DESIGN:  We performed a retrospective cohort study of women with two consecutive deliveries from 2005 to 2010. Analysis was limited to women with BMI recorded at <24 weeks for both pregnancies. Standard BMI categories were used. Adverse pregnancy outcomes included preterm birth at <37 weeks, intrauterine growth restriction (IUGR), pregnancy-related hypertension, and gestational diabetes mellitus (GDM)...
September 7, 2018: American Journal of Perinatology
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