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Intrauterine diabetes

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https://www.readbyqxmd.com/read/29786159/gestational-dyslipidaemia-and-adverse-birthweight-outcomes-a-systematic-review-and-meta-analysis
#1
REVIEW
J Wang, D Moore, A Subramanian, K K Cheng, K A Toulis, X Qiu, P Saravanan, M J Price, K Nirantharakumar
BACKGROUND: Low and high birthweight is known to increase the risk of acute and longer-term adverse outcomes, such as stillbirth, infant mortality, obesity, type 2 diabetes and cardiovascular diseases. Gestational dyslipidaemia is associated with a numbers of adverse birth outcomes, but evidence regarding birthweight is still inconsistent to reliably inform clinical practice and treatment recommendations. OBJECTIVE: The aim of this study was to explore the relationship between maternal gestational dyslipidaemia and neonatal health outcomes, namely, birthweight, metabolic factors and inflammatory parameters...
May 21, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29753320/adverse-effects-of-hif1a-mutation-and-maternal-diabetes-on-the-offspring-heart
#2
Radka Cerychova, Romana Bohuslavova, Frantisek Papousek, David Sedmera, Pavel Abaffy, Vladimir Benes, Frantisek Kolar, Gabriela Pavlinkova
BACKGROUND: Epidemiological studies show that maternal diabetes predisposes offspring to cardiovascular and metabolic disorders. However, the precise mechanisms for the underlying penetrance and disease predisposition remain poorly understood. We examined whether hypoxia-inducible factor 1 alpha, in combination with exposure to a diabetic intrauterine environment, influences the function and molecular structure of the adult offspring heart. METHODS AND RESULTS: In a mouse model, we demonstrated that haploinsufficient (Hif1a+/- ) offspring from a diabetic pregnancy developed left ventricle dysfunction at 12 weeks of age, as manifested by decreased fractional shortening and structural remodeling of the myocardium...
May 12, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29745237/association-between-progestin-only-contraceptive-use-and-cardiometabolic-outcomes-a-systematic-review-and-meta-analysis
#3
Marija Glisic, Sara Shahzad, Stergiani Tsoli, Mahmuda Chadni, Eralda Asllanaj, Lyda Z Rojas, Elizabeth Brown, Rajiv Chowdhury, Taulant Muka, Oscar H Franco
Aims The association between progestin-only contraceptive (POC) use and the risk of various cardiometabolic outcomes has rarely been studied. We performed a systematic review and meta-analysis to determine the impact of POC use on cardiometabolic outcomes including venous thromboembolism, myocardial infarction, stroke, hypertension and diabetes. Methods and results Nineteen observational studies (seven cohort and 12 case-control) were included in this systematic review. Of those, nine studies reported the risk of venous thromboembolism, six reported the risk of myocardial infarction, six reported the risk of stroke, three reported the risk of hypertension and two studies reported the risk of developing diabetes with POC use...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29739495/the-risks-associated-with-obesity-in-pregnancy
#4
Johannes Stubert, Frank Reister, Steffi Hartmann, Wolfgang Janni
BACKGROUND: Approximately one-third of all women of childbearing age are overweight or obese. For these women, pregnancy is associated with increased risks for both mother and child. METHODS: This review is based on pertinent publications retrieved by a selective search of PubMed, with special attention to current population-based cohort studies, systematic reviews, meta-analyses, and controlled trials. RESULTS: Obesity in pregnancy is associated with unfavorable clinical outcomes for both mother and child...
April 20, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29701769/fetal-origins-of-impaired-muscle-growth-and-metabolic-dysfunction-lessons-from-the-heat-stressed-pregnant-ewe
#5
D T Yates, J L Petersen, T B Schmidt, C N Cadaret, T B Barnes, R J Posont, K A Beede
Intrauterine growth restriction (IUGR) is the second leading cause of perinatal mortality and predisposes offspring to metabolic disorders at all stages of life. Muscle-centric fetal adaptations reduce growth and yield metabolic parsimony, beneficial for IUGR fetal survival but detrimental to metabolic health after birth. Epidemiological studies have reported that IUGR-born children experience greater prevalence of insulin resistance and obesity, which progresses to diabetes, hypertension, and other metabolic disorders in adulthood that reduce quality of life...
April 26, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29686379/maternal-early-pregnancy-obesity-and-related-pregnancy-and-pre-pregnancy-disorders-associations-with-child-developmental-milestones-in-the-prospective-predo-study
#6
Polina Girchenko, Soile Tuovinen, Marius Lahti-Pulkkinen, Jari Lahti, Katri Savolainen, Kati Heinonen, Riikka Pyhälä, Rebecca M Reynolds, Esa Hämäläinen, Pia M Villa, Eero Kajantie, Anu-Katriina Pesonen, Hannele Laivuori, Katri Räikkönen
BACKGROUND/OBJECTIVES: Previous studies have linked maternal pre-pregnancy obesity (BMI ≥30 kg/m2 ) with suboptimal neurodevelopment in her offspring; however, the literature is not entirely consistent. Whether these effects are muddled by maternal self-reports of pre-pregnancy weight and height, or are driven or amplified by the well often comorbid hypertensive and diabetic pregnancy and pre-pregnancy disorders, remains unclear. We examined whether maternal early pregnancy obesity is associated with developmental delay in her offspring, and if the associations are driven or amplified by diabetic and hypertensive pregnancy and pre-pregnancy disorders...
April 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29626501/birth-weight-predicts-aging-trajectory-a-hypothesis
#7
REVIEW
Alexander M Vaiserman
Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Fetal macrosomia (birth weight >4.5 kg), by contrast, is associated with high risk of non-diabetic obesity and cancers in later life...
April 4, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29621406/is-a-vegetarian-diet-safe-to-follow-during-pregnancy-a-systematic-review-and-meta-analysis-of-observational-studies
#8
Chang Tan, Yudi Zhao, Suqing Wang
BACKGROUND: Whether a vegetarian diet is appropriate for pregnancy remains unclear. OBJECTIVE: This study aimed to determine the association between vegetarian diet during pregnancy and various maternal-fetal outcomes. METHOD: PubMed-Medline, EMBASE, and Cochrane Library databases were searched for relevant articles published by August 30, 2017. Quantitative data were analyzed by a random-effects model with pooled odds ratios or weighted mean difference (WMD) and 95% confidence interval as aggregate estimations...
April 5, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29621322/sexual-dimorphism-in-the-association-between-gestational-diabetes-mellitus-and-overweight-in-offspring-at-5-7-years-the-obegest-cohort-study
#9
Nathalie Le Moullec, Adrian Fianu, Olivier Maillard, Emilie Chazelle, Nadège Naty, Chantal Schneebeli, Patrick Gérardin, Laetitia Huiart, Marie-Aline Charles, François Favier
Evidence from literature is mixed regarding a possible association of maternal gestational diabetes mellitus (GDM) and overweight in the offspring. Sexual dimorphism, or sex disparities in the pathogenesis linking GDM exposure to overweight, could be at play. The objective of this study was to investigate the association between GDM and child overweight at 5-7 years. Six hundred pairs (1:1) of Reunionese liveborn singletons selected from a hospital-based birth registry, matched for sex, gestational age, and birth period, underwent a prospective in-home follow-up and were analyzed with respect to their exposure to GDM...
2018: PloS One
https://www.readbyqxmd.com/read/29614340/maternal-lipopolysaccharide-exposure-results-in-glucose-metabolism-disorders-and-sex-hormone-imbalance-in-male-offspring
#10
Mei Zhao, Li Yuan, Man-Man Yuan, Li-Li Huang, Chang Su, Yuan-Hua Chen, Yu-Ying Yang, Yan Hu, De-Xiang Xu
An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were assessed at postnatal day (PND) 60 and PND120...
April 1, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29610268/diabetes-mellitus-in-pregnancy-leads-to-growth-restriction-and-epigenetic-modification-of-the-srebf2-gene-in-rat-fetuses
#11
Michaela Golic, Violeta Stojanovska, Ivo Bendix, Anika Wehner, Florian Herse, Nadine Haase, Kristin Kräker, Caroline Fischer, Natalia Alenina, Michael Bader, Till Schütte, Mirjam Schuchardt, Markus van der Giet, Wolfgang Henrich, Dominik N Muller, Ursula Felderhoff-Müser, Sicco Scherjon, Torsten Plösch, Ralf Dechend
Diabetic pregnancy is correlated with increased risk of metabolic and neurological disorders in the offspring putatively mediated epigenetically. Little is known about epigenetic changes already present in fetuses of diabetic pregnancies. We aimed at characterizing the perinatal environment after preexisting maternal diabetes mellitus and at identifying relevant epigenetic changes in the fetus. We focused on the transcription factor Srebf2 (sterol regulatory element binding transcription factor 2), a master gene in regulation of cholesterol metabolism...
April 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29610264/relevant-fetal-epigenetic-modifications-result-from-a-diabetic-intrauterine-environment-healthy-aging-starts-with-a-healthy-pregnancy
#12
EDITORIAL
Marco Scioscia
No abstract text is available yet for this article.
April 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29598691/intrauterine-hyperglycemia-is-associated-with-an-impaired-postnatal-response-to-oxidative-damage
#13
Jessica Tozour, Fabien Delahaye, Masako Suzuki, Aaron Praiss, Yongmei Zhao, Lingguang Cui, Hye J Heo, John Greally, Francine Hughes
Hyperglycemia and other adverse exposures early in life that reprogram stem cells may lead to long-lasting phenotypic influences over the lifetime of an individual. Hyperglycemia and oxidative stress cause DNA damage when they exceed the protective capabilities of the cell, in turn affecting cellular function. DNA damage in response to hyperglycemia and oxidative stress was studied in human umbilical cord mesenchymal stem cells (hUC-MSCs) from large for gestational age (LGA) infants of mothers with gestational diabetes (LGA-GDM) and control subjects...
March 29, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29593130/nonhuman-primate-breath-volatile-organic-compounds-associate-with-developmental-programming-and-cardio-metabolic-status
#14
Andrew C Bishop, Mark Libardoni, Ahsan Choudary, Biswapriya Biswavas Misra, Kenneth Lange, John Bernal, Mark Nijland, Cun Li, Michael Olivier, Peter W Nathanielsz, Laura A Cox
Rodent and nonhuman primate (NHP) studies indicate that developmental programming by reduced perinatal nutrition negatively impacts life course cardio-metabolic health. We have developed a baboon model in which we feed control mothers (CON) ad libitum while nutrient restricted mothers are fed 70% of ad libitum global feed in pregnancy and lactation. Offspring of nutrient restricted mothers are intrauterine growth restricted (IUGR) at term. By 3.5 years IUGR baboons showed signs of insulin resistance, indicating a pre-diabetic phenotype, in contrast to healthy CON offspring...
March 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29589286/genetic-and-environmental-contributions-to-variation-in-the-posterior-communicating-collaterals-of-the-circle-of-willis
#15
James E Faber, Hua Zhang, Wojciech Rzechorzek, Kathy Z Dai, Benjamin T Summers, Cooper Blazek, Samuel J Hedges
Variation in blood flow mediated by the posterior communicating collateral arteries (PComs) contributes to variation in the severity of tissue injury in obstructive disease. Evidence in animals and humans indicates that differences in the extent of PComs, i.e., their anatomic lumen diameter and whether they are present bilaterally, unilaterally, or absent, are a major factor. These differences arise during development since they are present at birth. However, the causal mechanisms are unknown. We used angiography after maximal dilation to examine involvement of genetic, environmental, and stochastic factors...
March 27, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29584790/extreme-umbilical-cord-lengths-cord-knot-and-entanglement-risk-factors-and-risk-of-adverse-outcomes-a-population-based-study
#16
Lorentz Erland Linde, Svein Rasmussen, Jörg Kessler, Cathrine Ebbing
OBJECTIVES: To determine risk factors for short and long umbilical cord, entanglement and knot. Explore their associated risks of adverse maternal and perinatal outcome, including risk of recurrence in a subsequent pregnancy. To provide population based gestational age and sex and parity specific reference ranges for cord length. DESIGN: Population based registry study. SETTING: Medical Birth Registry of Norway 1999-2013. POPULATION: All singleton births (gestational age>22weeks<45 weeks) (n = 856 300)...
2018: PloS One
https://www.readbyqxmd.com/read/29525518/obstetric-and-neonatal-outcome-in-women-aged-50-years-and-up-a-collaborative-nordic-population-based-study
#17
Ali Khatibi, Anne-Marie Nybo Andersen, Mika Gissler, Nils-Halvdan Morken, Bo Jacobsson
OBJECTIVES: Childbearing at extremely advanced maternal age is a globally increasing trend, but only a few studies have described the outcomes of these pregnancies. The aim of this study was to describe the occurrence of childbearing at age 50 and up in the Nordic countries, as well as to examine the frequency of adverse obstetric and neonatal outcomes. STUDY DESIGN: A descriptive population-based study was designed. Data from 1991 to 2013 were collected from the Medical Birth Registries in Denmark, Finland, Norway and Sweden...
May 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29523633/management-of-endocrine-disease-management-of-cushing-s-syndrome-during-pregnancy-solved-and-unsolved-questions
#18
REVIEW
Thierry Brue, Vincent Amodru, Frederic Castinetti
With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2- to 3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Apart from gestational hypertension, differential diagnosis includes pheochromocytoma and primary aldosteronism...
June 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29510088/vaginal-antimycotics-and-the-risk-for-spontaneous-abortions
#19
Sharon Daniel, Reut Rotem, Gideon Koren, Eitan Lunenfeld, Amalia Levy
BACKGROUND: Spontaneous abortions are the most common complication of pregnancy. Clotrimazole and miconazole are widely used vaginal-antimycotic agents used for the treatment of vulvovaginal candidiasis. A previous study has suggested an increased risk of miscarriage associated with these azoles, which may lead health professionals to refrain from their use even if clinically indicated. OBJECTIVE: The aim of the current study was to assess the risk for spontaneous abortions following first trimester exposure to vaginal antimycotics...
March 3, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29509436/developmental-origins-of-non-alcoholic-fatty-liver-disease-as-a-risk-factor-for-exaggerated-metabolic-and-cardiovascular-renal-disease
#20
Frank T Spradley, Jillian A Smith, Barbara T Alexander, Christopher D Anderson
Intrauterine growth restriction (IUGR) is linked to increased risk for chronic disease. Placental ischemia and insufficiency in the mother are implicated in predisposing IUGR offspring to metabolic dysfunction, including hypertension, insulin resistance, abnormalities in glucose homeostasis, and non-alcoholic fatty liver disease (NAFLD). Whether these metabolic disturbances contribute to the developmental origins of exaggerated cardiovascular-renal disease (CVRD) risk accompanying IUGR is unclear. IUGR impacts the pancreas, adipose tissue, and liver, which are hypothesized to program for hepatic insulin resistance and subsequent NAFLD...
March 6, 2018: American Journal of Physiology. Endocrinology and Metabolism
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