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https://www.readbyqxmd.com/read/29473944/non-endocannabinoid-n-acylethanolamines-and-2-monoacylglycerols-in-the-intestine
#1
REVIEW
Harald S Hansen, Vasiliki Vana
This review focuses on recent findings of the physiological and pharmacological role of non-endocannabinoid NAEs and 2-MAGs in the intestine and their involvement in the gut-brain signaling. Dietary fat suppress food intake and much research concerns the known gut peptides e.g. GLP-1, and CCK. NAEs and 2-MAGs represent another class of local gut signals most probably involved in the regulation of food intake. We discuss the putative biosynthetic pathways and targets of NAEs in the intestine as well as their anorectic role and changes in intestinal levels depending on the nutritional status...
February 23, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29472701/akkermansia-muciniphila-derived-extracellular-vesicles-influence-gut-permeability-through-the-regulation-of-tight-junctions
#2
Chaithanya Chelakkot, Youngwoo Choi, Dae-Kyum Kim, Hyun T Park, Jaewang Ghim, Yonghoon Kwon, Jinseong Jeon, Min-Seon Kim, Young-Koo Jee, Yong S Gho, Hae-Sim Park, Yoon-Keun Kim, Sung H Ryu
The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity and type 2 diabetes (T2D). Recently, Akkermansia muciniphila has been reported as a beneficial bacterium that reduces gut barrier disruption and insulin resistance. Here we evaluated the role of A. muciniphila-derived extracellular vesicles (AmEVs) in the regulation of gut permeability. We found that there are more AmEVs in the fecal samples of healthy controls compared with those of patients with T2D...
February 23, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29468820/effects-of-curcumin-consumption-on-human-chronic-diseases-a-narrative-review-of-the-most-recent-clinical-data
#3
REVIEW
Maria Mantzorou, Eleni Pavlidou, George Vasios, Eftychia Tsagalioti, Constantinos Giaginis
Numerous clinical trials have investigated the potential beneficial effects of curcumin supplementation against several human chronic diseases. Up to now, it has been claimed that curcumin consumption may exert beneficial effects against several chronic diseases by promoting human health and preventing diseases. In this aspect, the present review aims to critically collect and in-depth summarize the most recent, well-designed clinical studies evaluating the potential beneficial effects of curcumin consumption on human health promotion and disease prevention...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29466053/interplay-between-gut-microbiota-and-p66shc-affects-obesity-associated-insulin-resistance
#4
Stefano Ciciliot, Mattia Albiero, Stefano Campanaro, Nicol Poncina, Serena Tedesco, Valentina Scattolini, Francesca Dalla Costa, Andrea Cignarella, Monica Vettore, Iole Maria Di Gangi, Sara Bogialli, Angelo Avogaro, Gian Paolo Fadini
The 66 kDa isoform of the mammalian Shc gene promotes adipogenesis, and p66Shc-/- mice accumulate less body weight than wild-type (WT) mice. As the metabolic consequences of the leaner phenotype of p66Shc-/- mice is debated, we hypothesized that gut microbiota may be involved. We confirmed that p66Shc-/- mice gained less weight than WT mice when on a high-fat diet (HFD), but they were not protected from insulin resistance and glucose intolerance. p66Shc deletion significantly modified the composition of gut microbiota and their modification after an HFD...
February 21, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29462619/soluble-dietary-fiber-improves-energy-homeostasis-in-obese-mice-by-remodeling-the-gut-microbiota
#5
Haiyuan Wang, Tao Hong, Na Li, Bin Zang, Xingmao Wu
Intervention with dietary fibers is an important strategy to combat the global epidemic of obesity which is a consequence of energy imbalance. However, a possible role of the gut microbiota in effects of dietary fibers on energy homeostasis remains unclear. Here, we treated a high fat diet-induced obese (DIO) mouse model with soluble dietary fiber. Our results showed that soluble dietary fiber reduced body weight gain and the excessive accumulation of white fat tissue in DIO mice. Notably, soluble dietary fiber increased energy expenditure, but not change energy intake in DIO mice...
February 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29460474/specific-synbiotics-in-early-life-protect-against-diet-induced-obesity-in-adult-mice
#6
Mona Mischke, Tulika Arora, Sebastian Tims, Eefje Engels, Nina Sommer, Kees van Limpt, Annemarie Baars, Raish Oozeer, Annemarie Oosting, Fredrik Bäckhed, Jan Knol
AIMS: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health long-lastingly. Here, we determined how beneficial microbiome interventions in early life affect metabolic health in adulthood. METHODS: Postnatal diets were supplemented with either prebiotics (scGOS/lcFOS) or synbiotics (scGOS/lcFOS with Bifidobacterium breve M-16V) until post-natal (PN) day 42 in a well-established rodent model for nutritional programming...
February 20, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29459942/roles-of-birth-mode-and-infant-gut-microbiota-in-intergenerational-transmission-of-overweight-and-obesity-from-mother-to-offspring
#7
Hein M Tun, Sarah L Bridgman, Radha Chari, Catherine J Field, David S Guttman, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Anita L Kozyrskyj
Importance: Maternal overweight, which often results in cesarean delivery, is a strong risk factor for child overweight. Little is known about the joint contribution of birth mode and microbiota in the infant gut to the association between maternal prepregnancy overweight and child overweight. Objective: To investigate the association of birth mode with microbiota in the infant gut, and whether this mediates the association between maternal and child overweight...
February 19, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29456073/an-integrated-understanding-of-the-rapid-metabolic-benefits-of-a-carbohydrate-restricted-diet-on-hepatic-steatosis-in-humans
#8
Adil Mardinoglu, Hao Wu, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M Räsänen, Sunjae Lee, Rosellina M Mancina, Mattias Bergentall, Kirsi H Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D Piening, Marit Granér, Nina Lundbom, Kevin J Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, Marja-Riitta Taskinen, Jan Borén
A carbohydrate-restricted diet is a widely recommended intervention for non-alcoholic fatty liver disease (NAFLD), but a systematic perspective on the multiple benefits of this diet is lacking. Here, we performed a short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and characterized the resulting alterations in metabolism and the gut microbiota using a multi-omics approach. We observed rapid and dramatic reductions of liver fat and other cardiometabolic risk factors paralleled by (1) marked decreases in hepatic de novo lipogenesis; (2) large increases in serum β-hydroxybutyrate concentrations, reflecting increased mitochondrial β-oxidation; and (3) rapid increases in folate-producing Streptococcus and serum folate concentrations...
February 7, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29454391/type-1-diabetes-susceptibility-alleles-are-associated-with-distinct-alterations-in-the-gut-microbiota
#9
Jane A Mullaney, Juliette E Stephens, Mary-Ellen Costello, Cai Fong, Brooke E Geeling, Patrick G Gavin, Casey M Wright, Timothy D Spector, Matthew A Brown, Emma E Hamilton-Williams
BACKGROUND: Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. RESULTS: Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility...
February 17, 2018: Microbiome
https://www.readbyqxmd.com/read/29446938/hypoglycemic-effect-of-pyrodextrins-with-different-molecular-weights-and-digestibilities-in-diet-induced-obese-mice
#10
Yan Cao, Xiaoli Chen, Ying Sun, Jialiang Shi, Xiaojuan Xu, Yong-Cheng Shi
Pyrodextrin shares some properties of resistant starch which is metabolically beneficial, and has potential applications as a functional food. In this study, we report that oral administration of pyrodextrin (50 mg/kg/d for 7 weeks) decreased the blood glucose (from 9.18±1.47 to 7.67±0.42 mmol/L), serum HbA1c, triglycerides, adipocyte size, and body weights (from 24.4±1.2 to 22.5±1.2 g) in high-fat diet-induced obese mice. The Western blotting analysis suggested that pyrodextrins decreased the intestinal SGLT-1 and GLUT-2 expression to ~70% and ~60% of the obese control to slow down glucose transportation from gut into blood, and improved the hepatic metabolism tentatively...
February 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29443403/proceedings-of-the-2017-aspen-research-workshop-gastric-bypass-role-of-the-gut
#11
REVIEW
Ajay Kumar Jain, Carel W le Roux, Puneet Puri, Ali Tavakkoli, Nana Gletsu-Miller, Blandine Laferrère, Richard Kellermayer, John K DiBaise, Robert G Martindale, Bruce M Wolfe
The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29438462/butyrate-a-double-edged-sword-for-health
#12
Hu Liu, Ji Wang, Ting He, Sage Becker, Guolong Zhang, Defa Li, Xi Ma
Butyrate, a four-carbon short-chain fatty acid, is produced through microbial fermentation of dietary fibers in the lower intestinal tract. Endogenous butyrate production, delivery, and absorption by colonocytes have been well documented. Butyrate exerts its functions by acting as a histone deacetylase (HDAC) inhibitor or signaling through several G protein-coupled receptors (GPCRs). Recently, butyrate has received particular attention for its beneficial effects on intestinal homeostasis and energy metabolism...
January 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29437527/first-victim-later-aggressor-how-the-intestinal-microbiota-drives-the-pro-inflammatory-effects-of-dietary-emulsifiers
#13
Emilie Viennois, Benoit Chassaing
The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the gut microbiota. Composed of 500-1000 distinct species, the intestinal microbiota plays an important role in immunity and metabolism. However, alterations in its composition are associated with a variety of inflammatory diseases including obesity, diabetes, and inflammatory bowel disease (IBD). Among many other factors, our diet impacts microbiota composition and function, in either beneficial or detrimental ways...
February 13, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29434315/association-of-gut-microbial-communities-with-plasma-lipopolysaccharide-binding-protein-lbp-in-premenopausal-women
#14
Jessica S Citronberg, Keith R Curtis, Emily White, Polly A Newcomb, Katherine Newton, Charlotte Atkinson, Xiaoling Song, Johanna W Lampe, Meredith Aj Hullar
The mechanisms by which obesity increases cancer risk are unclear, but some lines of evidence suggest that gut microbial communities (GMC) may contribute to chronic inflammation in obese individuals through raised systemic levels of lipopolysaccharides (LPS). We evaluated associations of the GMC in stool with plasma LPS-binding protein (LBP, a measure of LPS) and C-reactive protein (CRP) concentrations in 110 premenopausal women in the United States. Diet was assessed using 3-day food records and GMCs were evaluated using pyrosequencing of the 16S rRNA gene...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29434314/elevated-circulating-levels-of-succinate-in-human-obesity-are-linked-to-specific-gut-microbiota
#15
Carolina Serena, Victoria Ceperuelo-Mallafré, Noelia Keiran, Maria Isabel Queipo-Ortuño, Rosa Bernal, Ricardo Gomez-Huelgas, Mireia Urpi-Sarda, Mónica Sabater, Vicente Pérez-Brocal, Cristina Andrés-Lacueva, Andres Moya, Francisco J Tinahones, Jose Manuel Fernández-Real, Joan Vendrell, Sonia Fernández-Veledo
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29429278/-the-relationship-between-gut-microbiota-and-diet-and-nutrition-related-diseases
#16
M Q Wang, Y Li, C H Sun
The human gastro-intestinal tract is not only the habitat of gut microbiota, but also the main place that the body gets available nutrients. Therefore, the gut microbiota of human can be inseparable associated with the human nutrition. The common technologies used among gut microbiota research included metageonomic, metatranscriptomics, metaproteomics, and metabolomics. The research of gut microbiota based on above omics methods confirmed that diets were the main factors influencing the composition and expression of gut microbiota...
February 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29428999/prospective-evaluation-of-insulin-and-incretin-dynamics-in-obese-adults-with-and-without-diabetes-for-2-years-after-roux-en-y-gastric-bypass
#17
Jonathan Q Purnell, Geoffrey S Johnson, Abdus S Wahed, Chiara Dalla Man, Francesca Piccinini, Claudio Cobelli, Ronald L Prigeon, Bret H Goodpaster, David E Kelley, Myrlene A Staten, Karen E Foster-Schubert, David E Cummings, David R Flum, Anita P Courcoulas, Peter J Havel, Bruce M Wolfe
AIMS/HYPOTHESIS: In this prospective case-control study we tested the hypothesis that, while long-term improvements in insulin sensitivity (S I ) accompanying weight loss after Roux-en-Y gastric bypass (RYGB) would be similar in obese individuals with and without type 2 diabetes mellitus, stimulated-islet-cell insulin responses would differ, increasing (recovering) in those with diabetes but decreasing in those without. We investigated whether these changes would occur in conjunction with favourable alterations in meal-related gut hormone secretion and insulin processing...
February 10, 2018: Diabetologia
https://www.readbyqxmd.com/read/29427903/the-gut-microbiota-as-a-novel-regulator-of-cardiovascular-function-and-disease
#18
REVIEW
Micah L Battson, Dustin M Lee, Tiffany L Weir, Christopher L Gentile
The gut microbiome has emerged as a critical regulator of human physiology. Deleterious changes to the composition or number of gut bacteria, commonly referred to as gut dysbiosis, has been linked to the development and progression of numerous diet-related diseases, including cardiovascular disease (CVD). Most CVD risk factors, including aging, obesity, certain dietary patterns, and a sedentary lifestyle, have been shown to induce gut dysbiosis. Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier, which in turn increases circulating levels of bacterial structural components and microbial metabolites that may facilitate the development of CVD...
December 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29427518/multi-omics-approach-to-elucidate-the-gut-microbiota-activity-metaproteomics-and-metagenomics-connection
#19
Maria Guirro, Andrea Costa, Andreu Gual-Grau, Jordi Mayneris-Perxachs, Helena Torrell, Pol Herrero, Núria Canela, Lluís Arola
Over the last few years, the application of high-throughput meta-omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to classical microbiology. Gut microbiota plays a crucial role in relevant diseases such as obesity or cardiovascular disease, and its regulation be closely influenced by several factors, such as dietary composition. In fact, polyphenol-rich diets are the most palatable treatment to prevent hypertension associated with cardiovascular disease, although the polyphenol-microbiota interactions have not been completely elucidated...
February 10, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29427445/green-tea-polyphenols-modulate-colonic-microbiota-diversity-and-lipid-metabolism-in-high-fat-diet-treated-hfa-mice
#20
Li Wang, Benhua Zeng, Zhiwei Liu, Zhenlin Liao, Qingping Zhong, Lihui Gu, Hong Wei, Xiang Fang
There is an increasing interest in the effect of dietary polyphenols on the intestinal microbiota and the possible associations between this effect and the development of obesity. However, limited information is available on how these polyphenols affect the gut microbiota and lipid metabolism. The co-action of a high-fat diet (HFD) and tea polyphenol (TP) on gut microbiota and lipid metabolism using a human flora-associated (HFA) C57BL/6J mice model is studied. TP reduced serum total cholesterol, triglyceride, low density lipoprotein, glucose (GLU) and insulin (INS) levels of HFD mice in a dose-dependent manner (P < 0...
February 10, 2018: Journal of Food Science
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