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Obesity methylation

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https://www.readbyqxmd.com/read/28621701/epigenetics-insights-into-chronic-pain-dna-hypomethylation-in-fibromyalgia-a-controlled-pilot-study
#1
Daniel Ciampi de Andrade, Mariana Maschietto, Ricardo Galhardoni, Gisele Gouveia, Thais Chile, Ana C Victorino Krepischi, Camila S Dale, André R Brunoni, Daniella C Parravano, Ana S Cueva Moscoso, Irina Raicher, Helena H S Kaziyama, Manoel J Teixeira, Helena P Brentani
To evaluate changes in DNA methylation profiles in patients with fibromyalgia (FM) compared to matched healthy controls (HCs). All individuals underwent full clinical and neurophysiological assessment by cortical excitability (CE) parameters measured by transcranial magnetic stimulation. DNA from the peripheral blood of patients with FM (n = 24) and HC (n = 24) were assessed using the Illumina-HumanMethylation450 BeadChips. We identified 1610 differentially methylated positions (DMPs) in patients with FM displaying a nonrandom distribution in regions of the genome...
June 15, 2017: Pain
https://www.readbyqxmd.com/read/28618859/sitagliptin-attenuates-endothelial-dysfunction-of-zucker-diabetic-fatty-rats
#2
Huanyuan Wang, Yi Zhou, Zhiying Guo, Yu Dong, Jiahui Xu, Haixia Huang, Huirong Liu, Wen Wang
Although the contributions of sitagliptin to endothelial function in diabetes mellitus were previously reported, the potential mechanisms still remain undefined. Our research was intended to explore the underlying mechanisms of protective effects of sitagliptin treatment on endothelial dysfunction in Zucker diabetic fatty (ZDF) rats. Male lean nondiabetic Zucker rats were used as control and male obese ZDF rats were randomly divided into ZDF and ZDF + sitagliptin groups. The significant decrease in endothelium-dependent relaxation induced by acetylcholine was observed in mesenteric arteries and thoracic aorta rings of ZDF rats...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28614626/ptprs-and-per3-methylation-levels-are-associated-with-childhood-obesity-results-from-a-genome-wide-methylation-analysis
#3
M Samblas, F I Milagro, M L Mansego, A Marti, J A Martinez
BACKGROUND: The global prevalence of childhood overweight and obesity has increased in the last years. Epigenetic dysregulation affecting gene expression could be a determinant in early-life obesity onset and accompanying complications. OBJECTIVE: The aim of the present investigation was to analyse the putative association between DNA methylation and childhood obesity. METHODS: DNA was isolated from white blood cells of 24 children obtained from the GENOI study and was hybridized in a 450K methylation array...
June 14, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28613268/vitamin-e-modifies-high-fat-diet-induced-increase-of-dna-strand-breaks-and-changes-in-expression-and-dna-methylation-of-dnmt1-and-mlh1-in-c57bl-6j-male-mice
#4
Marlene Remely, Franziska Ferk, Sonja Sterneder, Tahereh Setayesh, Tatjana Kepcija, Sylvia Roth, Rahil Noorizadeh, Martina Greunz, Irene Rebhan, Karl-Heinz Wagner, Siegfried Knasmüller, Alexander Haslberger
Obesity is associated with low-grade inflammation, increased ROS production and DNA damage. Supplementation with antioxidants might ameliorate DNA damage and support epigenetic regulation of DNA repair. C57BL/6J male mice were fed a high-fat (HFD) or a control diet (CD) with and without vitamin E supplementation (4.5 mg/kg body weight (b.w.)) for four months. DNA damage, DNA promoter methylation and gene expression of Dnmt1 and a DNA repair gene (MLH1) were assayed in liver and colon. The HFD resulted in organ specific changes in DNA damage, the epigenetically important Dnmt1 gene, and the DNA repair gene MLH1...
June 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28608766/wsf-p-1-a-novel-ampk-activator-promotes-adiponectin-multimerization-in-3t3-l1-adipocytes
#5
Yao Wang, Yudian Zhang, Yunyun Wang, Han Peng, Jian Rui, Zhijie Zhang, Shifa Wang, Zhen Li
Adiponectin, an adipokine with insulin-sensitizing effect, is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). The HMW adiponectin oligomers possess the most potent insulin-sensitizing activity. WSF-P-1(N-methyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4α-methanonaphthalen-7-amine) is derived from natural sesquiterpene longifolene by chemical modifications. We found that WSF-P-1 activates AMPK in both 3T3-L1 adipocytes and 293T cells in this study...
June 13, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28607629/the-impact-of-environmental-factors-in-influencing-epigenetics-related-to-oxidative-states-in-the-cardiovascular-system
#6
REVIEW
Francesco Angelini, Francesca Pagano, Antonella Bordin, Marika Milan, Isotta Chimenti, Mariangela Peruzzi, Valentina Valenti, Antonino Marullo, Leonardo Schirone, Silvia Palmerio, Sebastiano Sciarretta, Colin E Murdoch, Giacomo Frati, Elena De Falco
Oxidative states exert a significant influence on a wide range of biological and molecular processes and functions. When their balance is shifted towards enhanced amounts of free radicals, pathological phenomena can occur, as the generation of reactive oxygen species (ROS) in tissue microenvironment or in the systemic circulation can be detrimental. Epidemic chronic diseases of western societies, such as cardiovascular disease, obesity, and diabetes correlate with the imbalance of redox homeostasis. Current advances in our understanding of epigenetics have revealed a parallel scenario showing the influence of oxidative stress as a major regulator of epigenetic gene regulation via modification of DNA methylation, histones, and microRNAs...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28607499/kidney-cancer-methylation-of-obesity-related-genes-is-associated-with-prognosis
#7
Peter Sidaway
No abstract text is available yet for this article.
June 13, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28606512/heme-oxygenase-1-mediates-anti-adipogenesis-effect-of-raspberry-ketone-in-3t3-l1-cells
#8
Yung-Chieh Tsai, Bo-Cheng Yang, Wen-Huang Peng, Yen-Mei Lee, Mao-Hsiung Yen, Pao-Yun Cheng
BACKGROUND: Obesity is caused by excessive accumulation of body fat and is closely related to complex metabolic diseases. Raspberry ketone (RK), a major aromatic compound in red raspberry, was recently reported to possess anti-obesity effects. However, its mechanisms are unclear. AIM: Adipogenesis plays a critical role in obesity and, therefore, this study aimed to investigate the effect and mechanisms of action of RK on adipogenesis in 3T3-L1 preadipocytes. MATERIALS AND METHODS: 3T3-L1 preadipocytes were differentiated in medium containing insulin, dexamethasone, and 1-methyl-3-isobutylxanthine...
July 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28594926/rotating-night-work-lifestyle-factors-obesity-and-promoter-methylation-in-brca1-and-brca2-genes-among-nurses-and-midwives
#9
Beata Peplonska, Agnieszka Bukowska, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Edyta Reszka
Some recent evidence suggests that environmental and lifestyle factors may modify DNA methylation. We hypothesized that rotating night work and several modifiable factors may be associated with the methylation of the promoter regions within two tumor suppressor and DNA repair genes: BRCA1 and BRCA2. The methylation status of BRCA1 and BRCA2 was determined via qMSP reactions using DNA samples derived from blood leucocytes of 347 nurses and midwives working rotating nights and 363 working during the days. The subjects were classified into unmethylated vs methylated BRCA1 and BRCA2 when the methylation index was 0% or >0%, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28594380/effects-of-obesity-on-pro-oxidative-conditions-and-dna-damage-in-liver-of-dmba-induced-mammary-carcinogenesis-models
#10
Stepan Melnyk, Soheila Korourian, Joseph W Levy, Oleksandra Pavliv, Teresa Evans, Reza Hakkak
The prevalence of the overweight and obesity is on the rise worldwide. Obesity can increase the risk of certain cancers and liver steatosis development. Previously, we reported that obesity increased liver steatosis in a mammary tumor model, but little is known about the effects of obesity in the liver in regard to global DNA methylation, DNA damage, and oxidative/nitrosative stress. Using a mammary tumor model, we investigated the effects of obesity on oxidative stress and DNA reaction. Five-week-old lean and obese female rats were used...
June 8, 2017: Metabolites
https://www.readbyqxmd.com/read/28591744/multiple-gene-specific-dna-methylation-in-blood-leukocytes-and-colorectal-cancer-risk-a-case-control-study-in-china
#11
Yupeng Liu, Yibaina Wang, Fulan Hu, Hongru Sun, Zuoming Zhang, Xuan Wang, Xiang Luo, Lin Zhu, Rong Huang, Yan Li, Guangxiao Li, Xia Li, Shangqun Lin, Fan Wang, Yanhong Liu, Jiesheng Rong, Huiping Yuan, Yashuang Zhao
The relationship between gene-specific DNA methylation in peripheral blood leukocytes and colorectal cancer (CRC) susceptibility is unclear. In this case-control study, the methylation status of a panel of 10 CRC-related genes in 428 CRC cases and 428 cancer-free controls were detected with methylation-sensitive high-resolution melting analysis. We calculated a weighted methylation risk score (MRS) that comprehensively combined the methylation status of the panel of 10 genes and found that the MRS_10 was significantly associated with CRC risk...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28581876/hypolipidemic-activity-of-quercus-acutissima-fruit-ethanol-extract-is-mediated-by-inhibition-of-acetylation
#12
Jin-Taek Hwang, Hyo-Kyoung Choi, Sung Hee Kim, Sangwon Chung, Haeng Jeon Hur, Jae Ho Park, Min-Yu Chung
The acetylation of histone and nonhistone proteins is associated with adipogenesis. The objective of the present study was to investigate whether an ethanol extract of Quercus acutissima fruit (QF) exhibits antiobesity effects through inhibition of acetylation in 3T3-L1 preadipocytes and high fat diet (HFD)-fed obese mice. We observed that QF acts as a histone acetyltransferase (HAT) inhibitor and that QF (400 μg/mL) markedly inhibits the activity of p300 and CREB-binding protein. QF (200 μg/mL) significantly attenuated lipid accumulation without apparent toxicity, which is likely attributable to a decrease in the expressions of lipogenic proteins, including fatty acid synthase, peroxisome proliferator-activated receptor gamma, sterol regulatory element-binding protein 1, and CCAAT-enhancer-binding proteins alpha that were otherwise increased by MDI (a hormonal cocktail containing methyl isobutylmethylxanthine, dexamethasone, and insulin)...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28580281/glucagon-like-peptide-2-promotes-gallbladder-refilling-via-a-tgr5-independent-glp-2r-dependent-pathway
#13
Bernardo Yusta, Dianne Matthews, Grace B Flock, John R Ussher, Brigitte Lavoie, Gary M Mawe, Daniel J Drucker
OBJECTIVE: Glucagon-like peptides (GLPs) are secreted from enteroendocrine cells in response to nutrients and bile acids and control metabolism via actions on structurally-related yet distinct G protein coupled receptors. GLP-1 regulates gut motility, appetite, islet function, and glucose homeostasis, whereas GLP-2 enhances intestinal nutrient absorption. GLP-1R agonists are used to treat diabetes and obesity, and a GLP-2R agonist is approved to treat short bowel syndrome. Unexpectedly, reports of gallbladder disease have been associated with the use of both GLP-1R and GLP-2R agonists and after bariatric surgery, although the mechanisms remain unknown...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28580279/brown-adipose-tissue-bat-specific-vaspin-expression-is-increased-after-obesogenic-diets-and-cold-exposure-and-linked-to-acute-changes-in-dna-methylation
#14
Juliane Weiner, Kerstin Rohde, Kerstin Krause, Konstanze Zieger, Nora Klöting, Susan Kralisch, Peter Kovacs, Michael Stumvoll, Matthias Blüher, Yvonne Böttcher, John T Heiker
OBJECTIVE: Several studies have demonstrated anti-diabetic and anti-obesogenic properties of visceral adipose tissue-derived serine protease inhibitor (vaspin) and so evoked its potential use for treatment of obesity-related diseases. The aim of the study was to unravel physiological regulators of vaspin expression and secretion with a particular focus on its role in brown adipose tissue (BAT) biology. METHODS: We analyzed the effects of obesogenic diets and cold exposure on vaspin expression in liver and white and brown adipose tissue (AT) and plasma levels...
June 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28577936/association-between-dna-methylation-and-coronary-heart-disease-or-other-atherosclerotic-events-a-systematic-review
#15
REVIEW
Alba Fernández-Sanlés, Sergi Sayols-Baixeras, Isaac Subirana, Irene R Degano, Roberto Elosua
BACKGROUND AND AIMS: The aim of this study was to perform a systematic review of the association between DNA methylation and coronary heart disease (CHD) or related atherosclerotic traits. METHODS: A systematic review was designed. The condition of interest was DNA methylation, and the outcome was CHD or other atherosclerosis-related traits. Three DNA methylation approaches were considered: global methylation, candidate-gene, and epigenome-wide association studies (EWAS)...
May 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28572628/adipose-tissue-dysfunction-as-a-central-mechanism-leading-to-dysmetabolic-obesity-triggered-by-chronic-exposure-to-p-p-dde
#16
Diogo Pestana, Diana Teixeira, Manuela Meireles, Cláudia Marques, Sónia Norberto, Carla Sá, Virgínia C Fernandes, Luísa Correia-Sá, Ana Faria, Luísa Guardão, João T Guimarães, Wendy N Cooper, Ionel Sandovici, Valentina F Domingues, Cristina Delerue-Matos, Rosário Monteiro, Miguel Constância, Conceição Calhau
Endocrine-disrupting chemicals such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic context. We explored the effects of 12 weeks exposure in male Wistar rats' metabolism and AT biology, assessing a range of metabolic, biochemical and histological parameters. p,p'-DDE -treatment exacerbated several of the metabolic syndrome-accompanying features induced by high-fat diet (HF), such as dyslipidaemia, glucose intolerance and hypertension...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28559540/rs9939609-fto-genotype-associations-with-fto-methylation-level-influences-body-mass-and-telomere-length-in-an-australian-rural-population
#17
Y Zhou, D Simmons, D Lai, B D Hambly, C S McLachlan
BACKGROUND: the fat mass- and obesity-associated (FTO) gene influences energy homeostasis in humans. While the obesity-related variant, rs9939609 has been replicated across a number of cohort studies, there remain significant variance and a low modest association. Telomere length is another commonly reported obesity risk factor. We hypothesize understanding the associations between FTO rs9939609 with FTO methylation and telomere length will provide a more accurate assessment of obesity risk...
May 31, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28559210/cinnamaldehyde-in-diabetes-a-review-of-pharmacology-pharmacokinetics-and-safety
#18
REVIEW
Ruyuan Zhu, Haixia Liu, Chenyue Liu, Lili Wang, Rufeng Ma, Beibei Chen, Lin Li, Jianzhao Niu, Min Fu, Dongwei Zhang, Sihua Gao
Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent advances of cinnamaldehyde in its glucolipid lowering effects, its pharmacokinetics, and its safety by consulting the Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, National Science and Technology Library, Wanfang Data, and the Web of Science Databases...
May 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28554868/a-novel-deletion-of-snurf-snrpn-exon-1-in-a-patient-with-prader-willi-like-phenotype
#19
Yang Cao, Susan S AlHumaidi, Eissa A Faqeih, Beth A Pitel, Patrick Lundquist, Umut Aypar
Here we report the smallest deletion involving SNURF/SNRPN that causes major symptoms of Prader-Willi syndrome (PWS), including hypotonia, dysmorphic features, intellectual disability, and obesity. A female patient with the aforementioned and additional features was referred to the Mayo Clinic Cytogenetics laboratory for genetic testing. Chromosomal microarray analysis and subsequent Sanger sequencing identified a de novo 6.4 kb deletion at 15q11.2, containing exon 1 of the SNURF gene and exon 1 of the shortest isoform of the SNRPN gene...
May 26, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28545587/type-2-diabetes-and-obesity-induce-similar-transcriptional-reprogramming-in-human-myocytes
#20
Leif Väremo, Tora Ida Henriksen, Camilla Scheele, Christa Broholm, Maria Pedersen, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen
BACKGROUND: Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity. METHODS: We generated and analyzed RNA-seq data from primary differentiated myotubes from 24 human subjects, using a factorial design (healthy/T2D and non-obese/obese), to determine the influence of each specific factor on genome-wide transcription...
May 25, 2017: Genome Medicine
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