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Obesity mirna

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https://www.readbyqxmd.com/read/27907930/microrna-profiling-in-clear-cell-renal-cell-carcinoma-tissues-potentially-links-tumorigenesis-and-recurrence-with-obesity
#1
X Shu, M A Hildebrandt, J Gu, N M Tannir, S F Matin, J A Karam, C G Wood, X Wu
BACKGROUND: Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS: Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comparisons and Cox regression model was performed to compute hazard ratios (HRs) and corresponding 95% CIs. RESULTS: A 17-miRNA signature was identified that can concordantly classify >95% of tumour/adjacent normal samples...
December 1, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27904521/epigenetic-modifications-in-adipose-tissue-relation-to-obesity-and-diabetes
#2
Marta A Kasinska, Jozef Drzewoski, Agnieszka Sliwinska
The growing number of people suffering from obesity and type 2 diabetes mellitus (T2DM) is a global health problem that results in increased mortality from their complications, mainly cardiovascular diseases. Although the relationship between obesity and T2DM is well established, the common molecular pathomechanisms are still under investigation. Recently, it has been suggested that epigenetic modifications may be involved in both obesity and T2DM development. Epigenetics plays a pivotal role in the regulation of gene expression by the reversible modifications of chromatin structure without any changes in DNA sequence...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27902747/joint-profiling-of-mirnas-and-mrnas-reveals-mirna-mediated-gene-regulation-in-the-g%C3%A3-ttingen-minipig-obesity-model
#3
Caroline M Junker Mentzel, Ferhat Alkan, Helle Keinicke, Mette J Jacobsen, Jan Gorodkin, Merete Fredholm, Susanna Cirera
Obesity and its comorbidities are an increasing challenge for both affected individuals and health care systems, worldwide. In obese individuals, perturbation of expression of both protein-coding genes and microRNAs (miRNA) are seen in obesity-relevant tissues (i.e. adipose tissue, liver and skeletal muscle). miRNAs are small non-coding RNA molecules which have important regulatory roles in a wide range of biological processes, including obesity. Rodents are widely used animal models for human diseases including obesity...
2016: PloS One
https://www.readbyqxmd.com/read/27897405/premorbid-obesity-but-not-nutrition-prevents-critical-illness-induced-muscle-wasting-and-weakness
#4
Chloë Goossens, Mirna Bastos Marques, Sarah Derde, Sarah Vander Perre, Thomas Dufour, Steven E Thiessen, Fabian Güiza, Thomas Janssens, Greet Hermans, Ilse Vanhorebeek, Katrien De Bock, Greet Van den Berghe, Lies Langouche
BACKGROUND: The 'obesity paradox' of critical illness refers to better survival with a higher body mass index. We hypothesized that fat mobilized from excess adipose tissue during critical illness provides energy more efficiently than exogenous macronutrients and could prevent lean tissue wasting. METHODS: In lean and premorbidly obese mice, the effect of 5 days of sepsis-induced critical illness on body weight and composition, muscle wasting, and weakness was assessed, each with fasting and parenteral feeding...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27869909/altered-levels-of-circulating-cytokines-and-micrornas-in-lean-and-obese-individuals-with-prediabetes-and-type-2-diabetes
#5
Yury O Nunez Lopez, Gabriella Garufi, Attila A Seyhan
Today obesity and type 2 diabetes (T2D) have both reached epidemic proportions. However, our current understanding of the primary mechanisms leading to these diseases is still limited due to the complex multifactorial nature of the underlying phenomena. We hypothesize that the levels of specific cytokines and miRNAs vary across the diabetes spectrum and unique signatures associated with them may serve as early biomarkers of the disease and provide insights into respective pathogenetic mechanisms. In this study, we measured the circulating levels of cytokines and microRNAs (miRNAs) in lean and obese humans with prediabetes (n = 21), T2D (n = 17), and healthy controls (n = 20) (ORIGINS trial, NCT02226640)...
November 21, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27856635/micrornaa-155-deficiency-leads-to-decreased-atherosclerosis-increased-white-adipose-tissue-obesity-and-nonalcoholic-fatty-liver-disease-a-novel-mouse-model-of-obesity-paradox
#6
Anthony Virtue, Candice Johnson, Jahaira Lopez-Pastraña, Ying Shao, Hangfei Fu, Xinyuan Li, Ya-Feng Li, Ying Yin, Jietang Mai, Victor Rizzo, Michael Tordoff, Zsolt Bagi, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiao-Feng Yang
Obesity paradox (OP) describes a widely observed clinical finding of improved cardiovascular fitness and survival in some overweight or obese patients. The molecular mechanisms underlying OP remain enigmatic partly due to a lack of animal models mirroring OP in patients. Using apolipoprotein E knockout (ApoE-/-) mice on high-fat (HF) diet as an atherosclerotic obesity model, we demonstrated: 1) microRNA-155 (miRNA-155, miR-155) is significantly upregulated in aortas of ApoE-/- mice; and miR-155 deficiency in ApoE-/- mice inhibits atherosclerosis; 2) ApoE-/-/miR-155-/- (DKO) mice show HF diet-induced obesity, adipocyte hypertrophy and present with nonalcoholic fatty liver disease (NAFLD); 3) DKO mice demonstrate HF diet-induced elevations of plasma leptin, resistin, fed-state and fasting insulin, increased expression of adipogenic transcription factors, but lack glucose intolerance and insulin resistance...
November 17, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27842582/leptin-and-insulin-up-regulate-mir-4443-to-suppress-ncoa1-and-traf4-and-decrease-the-invasiveness-of-human-colon-cancer-cells
#7
Ari Meerson, Hila Yehuda
BACKGROUND: Obesity is a risk factor for colorectal cancer (CRC). Normal and tumor cells respond to metabolic hormones, such as leptin and insulin. Thus, obesity-associated resistance to these hormones likely leads to changes in gene expression and behavior of tumor cells. However, the mechanisms affected by leptin and insulin signaling in CRC cells remain mostly unknown. METHODS: We hypothesized that microRNAs (miRNAs) are involved in the regulation of tumorigenesis-related gene expression in CRC cells by leptin and insulin...
November 14, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27832630/decreased-mir-155-level-in-the-peripheral-blood-of-non-alcoholic-fatty-liver-disease-patients-may-serve-as-a-biomarker-and-may-influence-lxr-activity
#8
Lei Wang, Ning Zhang, Zun Wang, Dong-Mei Ai, Zhen-Yu Cao, Hua-Ping Pan
BACKGROUND: Obesity is now a common risk factor for non-alcoholic fatty liver disease (NAFLD). Thus, it is important to explore its underlying mechanisms. METHODS: Total RNA was extracted from peripheral whole blood samples from 50 NAFLD patients and 50 healthy controls. In addition, human liver specimens were obtained through liver biopsies from NAFLD patients and healthy controls. The level of miRNA was studied using real-time PCR. The expression of lipogenic genes was analyzed using western blot, and a dual luciferase reporter assay was conducted to identify the possible target gene...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27815534/biological-roles-of-micrornas-in-the-control-of-insulin-secretion-and-action
#9
Sophie Calderari, Malika Diawara, Alois Garaud, Dominique Gauguier
MicroRNAs (miRNAs) are intracellular and circulating molecular components contributing to genome expression control through binding mRNA targets, which generally results in downregulated mRNA expression. One miRNA can target several mRNAs and one transcript can be targeted by several miRNAs, resulting in complex fine tuning of regulation of gene networks and signaling pathways. miRNAs regulate metabolism, adipocyte differentiation, pancreatic development, β-cell mass, insulin biosynthesis, secretion and signaling and their role in diabetes and obesity is emerging...
November 4, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27812198/visceral-adipose-microrna-223-is-upregulated-in-human-and-murine-obesity-and-modulates-the-inflammatory-phenotype-of-macrophages
#10
Jeffrey A Deiuliis, Rafay Syed, Dheeraj Duggineni, Jessica Rutsky, Palanivel Rengasamy, Jie Zhang, Kun Huang, Bradley Needleman, Dean Mikami, Kyle Perry, Jeffrey Hazey, Sanjay Rajagopalan
Obesity in humans and mice is typified by an activated macrophage phenotype in the visceral adipose tissue (VAT) leading to increased macrophage-mediated inflammation. microRNAs (miRNAs) play an important role in regulating inflammatory pathways in macrophages, and in this study we compared miRNA expression in the VAT of insulin resistant morbidly obese humans to a non-obese cohort with normal glucose tolerance. miR-223-3p was found to be significantly upregulated in the whole omental tissue RNA of 12 human subjects, as were 8 additional miRNAs...
2016: PloS One
https://www.readbyqxmd.com/read/27789200/maternal-pre-pregnancy-body-mass-index-and-circulating-micrornas-in-pregnancy
#11
Daniel A Enquobahrie, Pandora L Wander, Mahlet G Tadesse, Chunfang Qiu, Claudia Holzman, Michelle A Williams
BACKGROUND: Maternal pre-pregnancy overweight and obese status has been associated with a number of pregnancy complications and adverse offspring outcomes. Mechanisms for observed associations, however, are largely unknown. We investigated associations of pre-pregnancy body mass index with early-mid pregnancy epigenetic biomarkers, circulating microRNAs. METHODS: Peripheral blood was collected from participants (16-27 weeks gestation) of two multi-racial pregnancy cohorts, the Omega Study and the Pregnancy Outcomes and Community Health Study...
October 24, 2016: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27762728/mir-138-mir-222-overexpression-characterizes-the-mirnome-of-amniotic-mesenchymal-stem-cells-in-obesity
#12
Carmela Nardelli, Ilaria Granata, Laura Iaffaldano, Valeria D'Argenio, Valentina Del Monaco, Giuseppe Maria Maruotti, Daniela Omodei, Luigi Del Vecchio, Pasquale Martinelli, Francesco Salvatore, Mario Rosario Guarracino, Lucia Sacchetti, Lucio Pastore
Clinical findings and data obtained in animal models indicate that nutrient uptake and exposure to environmental agents during pregnancy may affect fetal/newborn gestational programming, thereby resulting in obesity and/or obesity-related disorders in offspring. Human amniotic mesenchymal stem cells (hA-MSCs) differentiate into adipocytes and are thus a suitable model to investigate adipocyte functions in obesity. The aim of this study was to elucidate the miRNome of hA-MSCs and its contribution to obesity in pregnancy...
November 8, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27758866/mitochondrial-activity-in-human-white-adipocytes-is-regulated-by-the-ubiquitin-carrier-protein-9-microrna-30a-axis
#13
Eun Hee Koh, Yong Chen, David A Bader, Mark P Hamilton, Bin He, Brian York, Shingo Kajimura, Sean E McGuire, Sean M Hartig
The acquisition of beige adipocyte features by white fat cells corresponds to protection against obesity-induced metabolic diseases in humans and animal models of type 2 diabetes. In adipose tissue, expression of the E2 small ubiquitin-like modifier ligase ubiquitin carrier protein 9 (Ubc9) is positively correlated with markers of insulin resistance and corresponds with impaired browning of human white adipocytes. However, the molecular regulation of Ubc9 expression in adipocytes and other cells remains unclear...
November 18, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27736004/role-of-micrornas-on-the-regulation-of-mitochondrial-biogenesis-and-insulin-signaling-in-skeletal-muscle
#14
REVIEW
Tanes I Lima, Hygor N Araujo, Eveline S Menezes, Carlos H Sponton, Michel B Araújo, Lucas H M Bomfim, André L Queiroz, Madla A Passos, Thais Amaral E Sousa, Sandro M Hirabara, Amanda R Martins, Helena C L B Sampaio, Alice Rodrigues, Rui Curi, Everardo M Carneiro, Antônio C Boschero, Leonardo R Silveira
Mitochondria play a critical role in several cellular processes and cellular homeostasis. Mitochondrion dysfunction has been correlated with numerous metabolic diseases such as obesity and type 2 diabetes. MicroRNAs are non-coding RNAs that have emerged as key regulators of cell metabolism. The microRNAs act as central regulators of metabolic gene networks by leading to the degradation of their target messenger RNA or repression of protein translation. In addition, vesicular and non-vesicular circulating miRNAs exhibit a potential role as mediators of the cross-talk between the skeletal muscle and other tissues/organs...
October 13, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27731332/urinary-chromium-is-associated-with-changes-in-leukocyte-mirna-expression-in-obese-subjects
#15
L Dioni, S Sucato, V Motta, S Iodice, L Angelici, C Favero, T Cavalleri, L Vigna, B Albetti, S Fustinoni, P Bertazzi, A Pesatori, V Bollati
BACKGROUND/OBJECTIVES: Epidemiological studies suggest a link between chromium (Cr) status and cardiovascular disease. Increased urinary excretion of Cr was reported in subjects with diabetes compared with non-diabetic controls and those with non-diabetic insulin resistance. Epigenetic alterations have been linked to the presence of Cr, and microRNA (miRNA) expression has been implicated in the pathogenesis of metabolic diseases and cardiovascular diseases (CVDs). We investigated the association between Cr excretion and miRNA expression in leukocytes from obese subjects...
October 12, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27702393/sex-comparative-analysis-of-the-mirnome-of-human-amniotic-stem-cells-during-obesity
#16
Carmela Nardelli, Ilaria Granata, Laura Iaffaldano, Valeria D'Argenio, Valentina Del Monaco, Giuseppe Maria Maruotti, Luigi Del Vecchio, Pasquale Martinelli, Francesco Salvatore, Mario Rosario Guarracino, Lucia Sacchetti, Lucio Pastore
Experimental evidence indicates differences between women and men in several medical areas, including susceptibility to metabolic diseases. Sexual dimorphism could be influenced by microRNA (miRNA)-mediated regulation of gene expression, and miRNAs have also been implicated in fetal programming of obesity. Our previous finding of altered proteome in human amniotic stem cells (hA-MSCs) during obesity (Ob-) prompted us to look for gender-related differences in the miRNA regulation of gene expression in Ob-hA-MSCs that might be involved in metabolic changes...
October 5, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27693002/the-role-of-mirnas-in-cardiovascular-disease-risk-factors
#17
REVIEW
Joy N Jones Buie, Andrew J Goodwin, James A Cook, Perry V Halushka, Hongkuan Fan
Coronary artery disease and atherosclerosis are complex pathologies that develop over time due to genetic and environmental factors. Differential expression of miRNAs has been identified in patients with coronary artery disease and atherosclerosis, however, their association with cardiovascular disease risk factors, including hyperlipidemia, hypertension, obesity, diabetes, lack of physical activity and smoking, remains unclear. This review examines the role of miRNAs as either biomarkers or potential contributors to the pathophysiology of these aforementioned risk factors...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27669236/mir33a-mir33b-and-mir122-as-possible-contributors-to-hepatic-lipid-metabolism-in-obese-women-with-nonalcoholic-fatty-liver-disease
#18
Teresa Auguet, Gemma Aragonès, Alba Berlanga, Esther Guiu-Jurado, Andreu Martí, Salomé Martínez, Fàtima Sabench, Mercé Hernández, Carmen Aguilar, Joan Josep Sirvent, Daniel Del Castillo, Cristóbal Richart
Specific miRNA expression profiles have been shown to be associated with nonalcoholic fatty liver disease (NAFLD). We examined the correlation between the circulating levels and hepatic expression of miR122 and miR33a/b*, the key lipid metabolism-related gene expression and the clinicopathological factors of obese women with NAFLD. We measured miR122 and miR33a/b* expression in liver samples from 62 morbidly obese (MO), 30 moderately obese (ModO), and eight normal-weight controls. MiR122 and miR33a/b* expression was analyzed by qRT-PCR...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27639178/extracellular-vesicles-released-by-hepatocytes-from-gastric-infusion-model-of-alcoholic-liver-disease-contain-a-microrna-barcode-that-can-be-detected-in-blood
#19
Akiko Eguchi, Raul G Lazaro, Jiaohong Wang, Jihoon Kim, Davide Povero, Brandon Willliams, Samuel B Ho, Peter Stärkel, Bernd Schnabl, Lucila Ohno-Machado, Hidekazu Tsukamoto, Ariel E Feldstein
: Extracellular vesicles (EVs) released during cell stress, or demise, can contain a barcode of the cell origin, including specific microRNAs (miRNAs). Here, we tested the hypothesis that during early alcoholic steatohepatitis (ASH) development, hepatocytes (HCs) release EVs with an miRNA signature that can be measured in circulation. A time-course experiment showed that after 2 weeks of intragastric infusion, a time point that results in isolated steatosis, there was no increase of blood EVs...
September 17, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27627870/pregnancy-driven-cardiovascular-maternal-mir-29-plasticity-in-obesity
#20
N Schlabritz-Loutsevitch, K Apostolakis-Kyrus, R Krutilina, G Hubbard, M Kocak, Z Janjetovic, S Sathanandam, A T Slominski, G Mari, E Dick
BACKGROUND: Obesity in pregnancy (MO) is a risk factor for maternal and/or fetal cardiovascular system disorders. This study evaluated maternal CVS expression of microRNA-29 family and its target molecules in MO to test the hypotheses: CVS miR-29 concentrations are increased in pregnancy and decreased in MO. METHODS: Non-pregnant (n=4), pregnant obese (POb, n=4), and pregnant non-obese (PnOb, n=4) baboons (Papio spp.) were studied. Maternal left ventricle (LV), left atrium (LA), and aortic arch (AA) were collected at the end of gestation...
September 15, 2016: Journal of Medical Primatology
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