Tong Chen, Boqi Zhang, Guitian He, Nan Wang, Maosheng Cao, Caomeihui Shen, Xue Chen, Lu Chen, Kening Liu, Yuxin Luo, Yiqiu Huang, Chenfeng Yuan, Xu Zhou, Chunjin Li
Diseases like obesity and intestinal inflammation diseases are accompanied by dysbiosis of the gut microbiota (DSGM), which leads to various complications, including systemic metabolic disorders. DSGM reportedly impairs the fertility of male mice; however, the regulatory mechanism is unclear. Exosomes are molecular mediators of intercellular communication, but the regulation of spermatogenesis by non-reproductive tissue-originated exosomes remains unknown. The present study shows that DSGM altered the miRNA expression profile of mouse circulating exosomes and impaired spermatogenesis...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)