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https://www.readbyqxmd.com/read/29141971/role-of-microrna-regulation-in-obesity-associated-breast-cancer-nutritional-perspectives
#1
REVIEW
Ravi Kasiappan, Dheeran Rajarajan
Breast cancer is the most common malignancy diagnosed in women, and the incidence of breast cancer is increasing every year. Obesity has been identified as one of the major risk factors for breast cancer progression. The mechanisms by which obesity contributes to breast cancer development is not yet understood; however, there are a few mechanisms counted as potential producers of breast cancer in obesity, including insulin resistance, chronic inflammation and inflammatory cytokines, adipokines, and sex hormones...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29113498/decreased-serum-microrna-21-level-is-associated-with-obesity-in-healthy-and-type-2-diabetic-subjects
#2
Samira Ghorbani, Roya Mahdavi, Behnam Alipoor, Ghodratollah Panahi, Ensieh Nasli Esfahani, Farideh Razi, Mohhammad Taghikhani, Reza Meshkani
BACKGROUND: Recently, much attention has been paid to the role of circulating microRNAs (miRNAs) as novel biomarkers for various diseases. The aim of this study was to investigate the level of a subset of miRNAs in serum samples of the diabetic and healthy subjects. METHODS: Forty two healthy and 45 T2D subjects participated in this study. Serum miR-21, miR-126, and miR-146a levels were measured using real-time PCR. RESULTS: There was no significant difference in the serum level of miR-21, miR-126, and miR-146a between the diabetic and non-diabetic groups...
November 7, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29107764/current-attempts-to-implement-microrna-based-diagnostics-and-therapy-in-cardiovascular-and-metabolic-disease-a-promising-future
#3
Punniyakoti V Thanikachalam, Srinivasan Ramamurthy, Zheng W Wong, Koo B Jin, Wong J Ying, Mohd F B Abdullah, Chin Y Haur, Chia C Hou, Tan J Yi, Neo W Ting, Tan B Sen, Khan W Fang, Prashant Kesharwani
MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression at the post-translational level. miRNA-based therapeutic agents are important because of the functionality of miRNAs in regulating lipid and glucose metabolism and their role in the pathogenesis of metabolic disorders such as diabetes and obesity, where dysregulation leads to disease; they are also important in angiogenesis. miRNAs additionally serve as biomarkers in the diagnosis, prognosis and risk assessment of disease and in monitoring the response to treatment...
October 28, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29106399/a-microrna-screen-reveals-that-elevated-hepatic-ectodysplasin-a-expression-contributes-to-obesity-induced-insulin-resistance-in-skeletal-muscle
#4
Motoharu Awazawa, Paula Gabel, Eva Tsaousidou, Hendrik Nolte, Marcus Krüger, Joel Schmitz, P Justus Ackermann, Claus Brandt, Janine Altmüller, Susanne Motameny, F Thomas Wunderlich, Jan-Wilhelm Kornfeld, Matthias Blüher, Jens C Brüning
Over 40% of microRNAs (miRNAs) are located in introns of protein-coding genes, and many of these intronic miRNAs are co-regulated with their host genes. In such cases of co-regulation, the products of host genes and their intronic miRNAs can cooperate to coordinately regulate biologically important pathways. Therefore, we screened intronic miRNAs dysregulated in the livers of mouse models of obesity to identify previously uncharacterized protein-coding host genes that may contribute to the pathogenesis of obesity-associated insulin resistance and type 2 diabetes mellitus...
November 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29103239/elevated-levels-of-mir-122-in-serum-may-contribute-to-improved-endothelial-function-and-lower-oncologic-risk-following-bariatric-surgery
#5
Arnon Blum, Hila Yehuda, Nissim Geron, Ari Meerson
BACKGROUND: Weight loss surgery is the most effective treatment for obesity, and it reduces cardiovascular and cancer risk through poorly understood mechanisms. MicroRNAs (miRNAs) are short RNA molecules that regulate the stability and translation of many mRNAs. We hypothesized that levels of specific circulating miRNAs are altered following surgery and may contribute to lower cancer risk. OBJECTIVES: To investigate the change of miRNA following surgery. METHODS: All patients underwent gastric "sleeve operation"...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29101298/loss-of-microrna-22-prevents-high-fat-diet-induced-dyslipidemia-and-increases-energy-expenditure-without-affecting-cardiac-hypertrophy
#6
Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Xiaoyun Hu, Da-Zhi Wang
Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. In this study, we examined the role of miR-22 in the cardiac and metabolic alterations promoted by high fat (HF) diet. We found that loss of miR-22 attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be affected...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29077919/glucocorticoids-suppressing-the-browning-of-adipose-tissue-via-mir-19b-in-male-mice
#7
Yifan Lv, Jing Yu, Yunlu Sheng, Min Huang, Xiaocen Kong, Wenjuan Di, Juan Liu, Hong Zhou, Hui Liang, Guoxian Ding
Physiological levels of glucocorticoids are required for proper metabolic control, and excessive glucocorticoid action has been linked to a variety of pandemic metabolic diseases. microRNA (miRNA)-19b plays a critical role in the pathogenesis of glucocorticoid-induced metabolic diseases. This study sought to explore the potential of miRNA-based therapeutics targeting adipose tissue. Our results showed that overexpressed miR-19b in stromal vascular fraction cells derived from subcutaneous adipose tissue had the same effects as dexamethasone treatment on the inhibition of adipose browning and oxygen consumption rate...
October 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29054053/leptin-reduces-microrna-122-level-in-hepatic-stellate-cells-in-vitro-and-in-vivo
#8
Xuguang Zhai, Fangyun Cheng, Li Ji, Xiaofei Zhu, Qing Cao, Yali Zhang, Xin Jia, Qian Zhou, Wei Guan, Yajun Zhou
Obese patients, often accompanied by hyperleptinemia, are more likely to develop liver fibrosis. Leptin, an adipocyte-derived hormone, augments inflammatory in liver and promotes hepatic stellate cell (HSC) activation (a key step for liver fibrogenesis) and liver fibrosis. microRNA-122 (miR-122) is the most abundant liver-specific miRNA and can attenuate liver fibrosis. This study examined the effect of leptin on miR-122 level in HSCs in vivo and in vitro. Results demonstrated that leptin reduced the levels of both miR-122 (mature miR-122) and primary miR-122 (pri-miR-122)...
October 17, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29050301/mir-377-promotes-white-adipose-tissue-inflammation-and-decreases-insulin-sensitivity-in-obesity-via-suppression-of-sirtuin-1-sirt1
#9
Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Peng
Obesity is associated with a wide range of metabolic disorders including inflammation and insulin-resistance. Sirtuin-1 (SIRT1) is an important regulator of metabolic homeostasis and stress response pathways in white adipose tissue. However, involvement of microRNAs (miRNAs) in regulating SIRT1 during obesity-induced inflammation and insulin-resistance remains unclear. Here, we found that miR-377 was upregulated in adipose tissue and showed a negative correlation with SIRT1 in chronic high fat diet (HFD)-fed mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045034/differential-expression-profiles-of-circulating-micrornas-in-newborns-associated-to-maternal-pregestational-overweight-and-obesity
#10
A Méndez-Mancilla, V Lima-Rogel, J C Toro-Ortíz, F Escalante-Padrón, A E Monsiváis-Urenda, D E Noyola, M Salgado-Bustamante
BACKGROUND: The perinatal environment has a role in the establishment of altered metabolic and inflammatory responses, and could be modulated by microRNAs regulating immune and metabolic processes. OBJECTIVE: To analyze the expression profile of four circulating microRNAs and cytokine serum concentrations in neonates born to overweight and obese women. METHODS: Pregnant women were included and grouped by pregestational body mass index (21 with normal weight, 10 overweight and 10 obese women)...
October 17, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/29027120/elucidating-the-preadipocyte-and-its-role-in-adipocyte-formation-a-comprehensive-review
#11
REVIEW
Christos N Sarantopoulos, Derek A Banyard, Mary E Ziegler, Beatrice Sun, Ashkaun Shaterian, Alan D Widgerow
Adipogenesis is a complex process whereby the multipotent adipose-derived stem cell is converted to a preadipocyte before terminal differentiation into the mature adipocyte. Preadipocytes are present throughout adult life, exhibit adipose fat depot specificity, and differentiate and proliferate from distinct progenitor cells. The mechanisms that promote preadipocyte commitment and maturation involve numerous protein factor regulators, epigenetic factors, and miRNAs. Detailed characterization of this process is currently an area of intense research and understanding the roles of preadipocytes in tissue plasticity may provide insight into novel approaches for tissue engineering, regenerative medicine and treating a host of obesity-related conditions...
October 13, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29024341/modulation-of-human-subcutaneous-adipose-tissue-microrna-profile-associated-with-changes-in-adiposity-related-parameters
#12
Simona Giardina, Pablo Hernández-Alonso, Jordi Salas-Salvadó, Antoni Rabassa-Soler, Mònica Bulló
SCOPE: To analyze the effect of three calorie-restricted diets with different amount and quality of carbohydrates on subcutaneous adipose tissue (SAT) miRNA profile. METHODS AND RESULTS: 6-month, parallel, randomized trial conducted on overweight and obese subjects randomized to: 1) low glycemic index diet (LGI), 2) high glycemic index diet (HGI), and 3) low-fat (LF). The genome-wide SAT miRNA profile was assessed in 8 randomly selected participants and the most relevant changing miRNAs (n = 13) were validated in 48 subjects...
October 10, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28983252/evaluation-of-muscle-microrna-expression-in-relation-to-human-peripheral-insulin-sensitivity-a-cross-sectional-study-in-metabolically-distinct-subject-groups
#13
Dennis Dahlmans, Alexandre Houzelle, Johanna A Jörgensen, Esther Phielix, Lucas Lindeboom, Matthijs K C Hesselink, Patrick Schrauwen, Joris Hoeks
In recent years, several microRNAs (miRNAs)-post-transcriptional regulators of gene expression-have been linked to the regulation of peripheral insulin sensitivity. Many of these studies, however, have been conducted in cell or animal models and the few human studies available lack adequate measurements of peripheral insulin sensitivity. In the present study, we examined the expression of 25 miRNAs, putatively involved in (peripheral) insulin sensitivity, in skeletal muscle biopsies from extensively phenotyped human individuals, widely ranging in insulin sensitivity...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28974990/role-of-micrornas-in-obesity-and-obesity-related-diseases
#14
REVIEW
Giuseppe Iacomino, Alfonso Siani
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in maintaining/altering physiological processes, including energy balance and metabolic homeostasis. Altered miRNAs expression has been reported in association with obesity, both in animal and human studies. Dysregulation of miRNAs may affect the status and functions of different tissues and organs, including the adipose tissue, pancreas, liver, and muscle, possibly contributing to metabolic abnormalities associated with obesity and obesity-related diseases...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28970082/identification-and-functional-verification-of-micrornas-in-the-obese-rat-with-erectile-dysfunction
#15
Yunlong Bai, Liangshuan Zhang, Yanan Jiang, Jiaming Ju, Guiyang Li, Juan Xu, Xing Jiang, Peng Zhang, Linchuan Lang, Olga Sadkovaya, Peter V Glybochko, Wei Zhang, Baofeng Yang
INTRODUCTION: Obesity is a potential risk factor for erectile dysfunction (ED). MicroRNAs (miRNAs) regulate the expression of genes involved in various pathophysiologic processes. AIM: To identify the miRNA profile in the corpus cavernosum (CC) of obese rats with ED and elucidate the potential function of miRNA in the pathogenesis of ED. METHODS: Obesity was induced in rats by a high-fat diet. After the erectile function test, experimental animals were divided into two groups: obese rats with ED and obese rats with normal erectile function...
December 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28966078/change-in-circulating-microrna-profile-of-obese-children-indicates-future-risk-of-adult-diabetes
#16
Xianwei Cui, Lianghui You, Lijun Zhu, Xing Wang, Yahui Zhou, Yun Li, Juan Wen, Yankai Xia, Xinru Wang, Chenbo Ji, Xirong Guo
PURPOSE: Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults. Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic biomarkers, and they may contribute to the progression toward T2D. Here, we investigated the possibility of predicting the future risk of adult T2D in obese children by using circulating miRNAs. BASIC PROCEDURES: We performed miRNA high-throughput sequencing to screen relevant circulating miRNAs in obese children...
September 28, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28954844/adipose-tissue-inflammation-in-insulin-resistance-review-of-mechanisms-mediating-anti-inflammatory-effects-of-omega-3-polyunsaturated-fatty-acids
#17
Mandana Pahlavani, Theresa Ramalho, Iurii Koboziev, Monique J LeMieux, Shasika Jayarathne, Latha Ramalingam, Luciano R Filgueiras, Naima Moustaid-Moussa
Obesity is an increasingly costly and widespread epidemic, effecting 1 in 10 adults worldwide. It has been causally linked with both the metabolic syndrome and insulin resistance, both of which are associated with increased chronic inflammation. The exact mechanisms through which inflammation may contribute to both MetS and IR are numerous and their details are still largely unknown. Recently, micro-RNAs (miRNAs) have emerged as potential interventional targets due to their potential preventive roles in the pathogenesis of several diseases, including MetS and obesity...
September 27, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28951825/micrornas-as-stress-regulators-in-pancreatic-beta-cells-and-diabetes
#18
REVIEW
Mary P LaPierre, Markus Stoffel
BACKGROUND: MicroRNAs have emerged as important regulatory non-coding RNAs that tune cellular responses to physiological perturbations and disease conditions. An increasing body of literature underlines the important roles of miRNA function in pancreatic β-cells in response to metabolic, genetic and inflammatory stress. Lessons from genetic loss- and gain-of-function studies have implicated several highly expressed and evolutionary conserved miRNAs in stress signal modulation, resolution and buffering, thereby forming stabilizing miRNA networks that preserve β-cell differentiation, function, proliferation and cell survival...
September 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28947593/mir155-deficiency-aggravates-high-fat-diet-induced-adipose-tissue-fibrosis-in-male-mice
#19
Kandy T Velázquez, Reilly T Enos, Meredith S Carson, Taryn L Cranford, Jackie E Bader, Alexander T Sougiannis, Cara Pritchett, Daping Fan, James A Carson, E Angela Murphy
Noncoding RNAs are emerging as regulators of inflammatory and metabolic processes. There is evidence to suggest that miRNA155 (miR155) may be linked to inflammation and processes associated with adipogenesis. We examined the impact of global miRNA-155 deletion (miR155(-/-)) on the development of high-fat diet (HFD)-induced obesity. We hypothesized that loss of miR155 would decrease adipose tissue inflammation and improve the metabolic profile following HFD feedings. Beginning at 4-5 weeks of age, male miR155(-/-) and wild-type (WT) mice (n = 13-14) on a C57BL/6 background were fed either a HFD or low-fat diet for 20 weeks...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28942920/adipose-tissue-macrophage-derived-exosomal-mirnas-can-modulate-in%C3%A2-vivo-and-in%C3%A2-vitro-insulin-sensitivity
#20
Wei Ying, Matthew Riopel, Gautam Bandyopadhyay, Yi Dong, Amanda Birmingham, Jong Bae Seo, Jachelle M Ofrecio, Joshua Wollam, Angelina Hernandez-Carretero, Wenxian Fu, Pingping Li, Jerrold M Olefsky
MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained from lean mice improve glucose tolerance and insulin sensitivity when administered to obese recipients. miR-155 is one of the miRNAs overexpressed in obese ATM Exos, and earlier studies have shown that PPARγ is a miR-155 target...
October 5, 2017: Cell
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