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Diabetes mirna

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https://www.readbyqxmd.com/read/28939211/mirnas-nanomachines-that-micromanage-the-pathophysiology-of-diabetes-mellitus
#1
Shilpy Sharma, Abraham B Mathew, Jeetender Chugh
Diabetes mellitus (DM) refers to a combination of heterogeneous complex metabolic disorders that are associated with episodes of hyperglycemia and glucose intolerance occurring as a result of defects in insulin secretion, action, or both. The prevalence of DM is increasing at an alarming rate, and there exists a need to develop better therapeutics and prognostic markers for earlier detection and diagnosis. In this review, after giving a brief introduction of diabetes mellitus and microRNA (miRNA) biogenesis pathway, we first describe various in vitro and animal model systems that have been developed to study diabetes...
2017: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/28938471/low-vitamin-b12-in-pregnancy-is-associated-with-adipose-derived-circulating-mirs-targeting-ppar%C3%AE-and-insulin-resistance
#2
Antonysunil Adaikalakoteswari, Manu Vatish, Mohammad Tauqeer Alam, Sascha Ott, Sudhesh Kumar, Ponnusamy Saravanan
Context: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance(IR) and gestational diabetes(GDM). B12 is a key co-factor in 1-carbon metabolism. Objective: We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs(miRs) during adipocyte differentiation and results in an adverse metabolic phenotype. Design, settings and main-outcome measure: Human pre-adipocyte cell-line(Chub-S7) were differentiated in various B12 concentrations: Control(500nM), LowB12(0...
September 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28934669/transforming-growth-factor-beta-tgf-%C3%AE-mediates-cardiac-fibrosis-and-induces-diabetic-cardiomyopathy
#3
REVIEW
Yiyang Yue, Ke Meng, Yuejie Pu, Xiaoming Zhang
Cardiovascular diseases account for the major cause of morbidity and mortality among individuals with diabetes. The diabetic cardiomyopathy (DCM) is a type of diabetic cardiovascular disease, which further directs to the heart failure. The researchers found that diabetes induced cardiac fibrosis plays a vital role in several of the pathological changes that associated with DCM, causing left ventricular hypertrophy (LVH), diastolic dysfunction and systolic dysfunction. However, the mechanisms involved in the pathogenesis of DCM are still elusive...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28927403/circulating-levels-and-characterization-of-microparticles-in-patients-with-different-degrees-of-glucose-tolerance
#4
Alessandra Giannella, Claudia Maria Radu, Lorenzo Franco, Elena Campello, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg, Giulio Ceolotto
BACKGROUND: Microparticles (MPs) are vesicular structures shed from endothelial or circulating blood cells, after activation or apoptosis, and can be considered markers of vascular damage. We aimed to determine the levels of circulating MPs, their content of miRNA-126-3p and 5p, and their relationship with early endothelial activation/damage, in patients with different degree of glucose tolerance. METHODS: CD62E(+), CD62P(+), CD142(+), CD45(+) circulating MPs, their apoptotic (AnnexinV(+)) fractions, and miRNA-126 expression were determined in 39 prediabetic (PreDM), 68 type 2 diabetic (T2DM), and 53 control (NGT) subjects, along with main anthropometric and biochemical measurements...
September 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28919327/endothelial-microparticle-promoted-inhibition-of-vascular-remodeling-is-abrogated-under-hyperglycaemic-conditions
#5
Felix Jansen, Andreas Zietzer, Tobias Stumpf, Anna Flender, Theresa Schmitz, Georg Nickenig, Nikos Werner
BACKGROUND: Endothelial microparticles (EMPs) inhibit vascular remodeling by transferring functional microRNA (miRNA) into target vascular smooth muscle cells (VSMCs). Because EMPs are increased in diabetic patients and potentially linked to vascular complications in diabetes mellitus, we sought to determine whether effects of EMPs generated under high glucose concentration on vascular remodeling might differ from EMPs derived from untreated cells. METHODS AND RESULTS: EMPs were generated from human coronary endothelial cells (HCAEC) exposed to high glucose concentrations in order to mimic diabetic conditions...
September 14, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28915303/prevalence-of-functional-dentition-in-a-group-of-mexican-adult-males
#6
Mirna Minaya-Sánchez, Carlo Eduardo Medina-Solís, Juan Fernando Casanova-Rosado, Ana Alicia Vallejos-Sánchez, Alejandro José Casanova-Rosado, María de Lourdes Márquez-Corona, Martha Mendoza-Rodríguez, Gerardo Maupomé
OBJECTIVE: To determine the prevalence of functional dentition and associated periodontal variables in a sample of Mexican adult males. METHODS: A cross-sectional study of 161 policemen in Campeche, Mexico, was carried out. A clinical examination using an electronic probe was used to collect variables (dental plaque, periodontal pockets, gingival recession, suppuration, and bleeding on probing) on 6 periodontal sites (a maximum of 168 sites, excluding third molars)...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28906481/insights-into-the-diagnostic-potential-of-extracellular-vesicles-and-their-mirna-signature-from-liquid-biopsy-as-early-biomarkers-of-diabetic-micro-macrovascular-complications
#7
REVIEW
Valeria La Marca, Alessandra Fierabracci
Extracellular vesicles (EVs) represent a heterogeneous population of small vesicles, consisting of a phospholipidic bilayer surrounding a soluble interior cargo. Almost all cell types release EVs, thus they are naturally present in all body fluids. Among the several potential applications, EVs could be used as drug delivery vehicles in disease treatment, in immune therapy because of their immunomodulatory properties and in regenerative medicine. In addition to general markers, EVs are characterized by the presence of specific biomarkers (proteins and miRNAs) that allow the identification of their cell or tissue origin...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28904427/micrornas-involvement-in-renal-pathophysiology-a-bird-s-eye-view
#8
REVIEW
P Jaswani, S Prakash, A Dhar, R K Sharma, N Prasad, S Agrawal
MicroRNAs (miRNAs) are known to suppress gene expression by binding to messenger RNAs and in turn regulate different pathophysiological processes. Transforming growth factor-β, mitogen-activated protein kinase signaling, and Wnt signaling-like major pathways associated with miRNAs are involved with kidney diseases. The discovery of miRNAs has provided new insights into kidney pathologies and may provide effective therapeutic strategies. Research has demonstrated the role of miRNAs in a variety of kidney diseases including diabetic nephropathy, lupus nephritis, hypertension, nephritic syndrome, acute kidney injury, renal cell carcinoma, and renal fibrosis...
September 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28899883/microrna-146a-mimics-reduce-the-peripheral-neuropathy-in-type-ii-diabetic-mice
#9
Xian Shuang Liu, Baoyan Fan, Alexandra Szalad, Longfei Jia, Lei Wang, Xinli Wang, Wanlong Pan, Li Zhang, Ruilan Zhang, Jiani Hu, Xiao Ming Zhang, Michael Chopp, Zheng Gang Zhang
MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type II diabetes exhibited substantial down-regulation of miR-146a in sciatic nerve tissue. Systemic administration of miR-146a mimics to diabetic mice elevated miR-146a levels in plasma and sciatic nerve tissue and substantially increased motor and sensory nerve conduction velocities by 29% and 11%, respectively, and regional blood flow by 50% in sciatic nerve tissue...
September 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28898588/micrornas-in-the-pathogenesis-of-type-2-diabetes-new-research-progress-and-future-direction
#10
Chenggui Miao, Guoxue Zhang, Zhongwen Xie, Jun Chang
MicroRNA (miRNA) is a short non-coding RNA that can influence messenger RNA (mRNA) processing at the post-transcriptional level. A large number of miRNAs have been found in virtually all species so far, and these small molecules play an important role in many different physiological processes and various pathologic conditions, such as cell metabolism, cancer, autoimmune disease, and diabetes mellitus. Type 2 diabetes (T2D) arises from a dysregulated response to the elevated glucose level in the circulation...
September 12, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28883608/gyy4137-a-hydrogen-sulfide-donor-modulates-mir194-dependent-collagen-realignment-in-diabetic-kidney
#11
A M Sashi Papu John, Sourav Kundu, Sathnur Pushpakumar, Maura Fordham, Gregory Weber, Manas Mukhopadhyay, Utpal Sen
The relationship between hydrogen sulfide (H2S), microRNAs (miRs), matrix metalloproteinases (MMPs) and poly-ADP-ribose-polymerase-1 (PARP-1) in diabetic kidney remodeling remains mostly obscured. We aimed at investigating whether alteration of miR-194-dependent MMPs and PARP-1 causes renal fibrosis in diabetes kidney, and whether H2S ameliorates fibrosis. Wild type, diabetic Akita mice as well as mouse glomerular endothelial cells (MGECs) were used as experimental models, and GYY4137 as H2S donor. In diabetic mice, plasma H2S levels were decreased while ROS and expression of its modulator (ROMO1) were increased...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880477/exosomes-as-new-players-in-metabolic-organ-cross-talk
#12
REVIEW
Claudiane Guay, Romano Regazzi
Blood glucose homeostasis requires a constant communication between insulin-secreting and insulin-sensitive cells. A wide variety of circulating factors, including hormones, cytokines and chemokines work together to orchestrate the systemic response of metabolic organs to changes in the nutritional state. Failure in the coordination between these organs can lead to a rise in blood glucose levels and to the appearance of metabolic disorders such as diabetes mellitus. Exosomes are small extracellular vesicles (EVs) that are produced via the endosomal pathway and are released from the cells upon fusion of multivesicular bodies with the plasma membrane...
September 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28878735/microrna-regulation-of-brown-adipogenesis-and-thermogenic-energy-expenditure
#13
REVIEW
Farnaz Shamsi, Hongbin Zhang, Yu-Hua Tseng
Obesity, diabetes, and associated metabolic diseases have become global epidemics. Obesity results from excess accumulation of white fat, while brown and its related beige fat function to dissipate energy as heat, thus counteracting obesity and its related metabolic disorders. Understanding the regulatory mechanisms for both white and brown adipogenesis provides new insights for prevention and treatment of these metabolic diseases. In addition to traditional gene transcription and translation, microRNA (miRNA) represents a new layer of regulatory mechanism in many biological processes and has attracted a great deal of research interests in exploring their roles in physiological and pathophysiological conditions...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28868048/extracellular-vesicles-from-adipose-tissue-a-potential-role-in-obesity-and-type-2-diabetes
#14
REVIEW
Xuan Gao, Carlos Salomon, Dilys J Freeman
Adipose tissue plays a key role in the development of insulin resistance and its pathological sequelae, such as type 2 diabetes and non-alcoholic fatty liver disease. Dysfunction in the adipose tissue response to storing excess fatty acids as triglyceride can lead to adipose tissue inflammation and spillover of fatty acids from this tissue and accumulation of fatty acids as lipid droplets in ectopic sites, such as liver and muscle. Extracellular vesicles (EVs) are released from adipocytes and have been proposed to be involved in adipocyte/macrophage cross talk and to affect insulin signaling and transforming growth factor β expression in liver cells leading to metabolic disease...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28858844/can-regular-moderate-exercise-lead-to-changes-in-mirna-146a-and-its-adapter-proteins-in-the-kidney-of-streptozotocin-induced-diabetic-male-rats
#15
H Oghbaei, N Ahmadi Asl, F Sheikhzadeh
OBJECTIVE: The aim of this study was to assess whether microRNA-146a and its adapter proteins TNF receptor associated factor6 (TRAF6) and interleukin-1 receptor-associated kinase-1 (IRAK1) may be changed in the kidney of streptozotocin-induced diabetic rats, following regular moderate exercise. METHODS: Forty adult male Wistar rats were allocated randomly into four groups (n=10), including sedentary control (SC), sedentary diabetic (SD), healthy sixty-day exercise (H60E), and diabetic sixty-day exercise (D60E) groups...
July 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28846711/identification-of-novel-biomarkers-to-monitor-%C3%AE-cell-function-and-enable-early-detection-of-type-2-diabetes-risk
#16
Kirstine J Belongie, Ele Ferrannini, Kjell Johnson, Patricia Andrade-Gordon, Michael K Hansen, John R Petrie
A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in part, to the fact that current methods for assessing β-cell function are inaccurate, prone to error, labor-intensive, or affected by glucose-lowering therapy. The aim of the current study was to identify novel circulating biomarkers to monitor β-cell function and to identify individuals at high risk of developing β-cell dysfunction...
2017: PloS One
https://www.readbyqxmd.com/read/28842356/impact-of-micrornas-on-ischemic-stroke-from-pre-to-post-disease
#17
REVIEW
Guangwen Li, Kahlilia C Morris-Blanco, Mary S Lopez, Tuo Yang, Haiping Zhao, Raghu Vemuganti, Yumin Luo
Stroke is the number one cause of neurological dysfunction in adults and has a heavy socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting pathological processes are mediated by a multifaceted cascade of molecular mechanisms that are in part modulated by posttranscriptional activity. Accumulating evidence has revealed a role for microRNAs (miRNAs) as essential mediators of posttranscriptional gene silencing in both the physiology of brain development and pathology of ischemic stroke...
August 24, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28839467/circular-rnas-regulators-of-cancer-related-signaling-pathways-and-potential-diagnostic-biomarkers-for-human-cancers
#18
REVIEW
Zuozhang Yang, Lin Xie, Lei Han, Xin Qu, Yihao Yang, Ya Zhang, Zewei He, Yu Wang, Jing Li
Circular RNAs (circRNAs) are newly discovered endogenous non-coding RNAs featuring structural stability, high abundance, and tissue-specific expression. CircRNAs are prevalent and conserved in mammalian cells. They are involved in cellular processes and regulate gene expression at the transcriptional or post-transcriptional level by interacting with microRNAs (miRNAs) and other molecules. Recent studies have shown that circRNAs play an important role in the progression of various human diseases including atherosclerosis, nervous system disorders, diabetes, and cancer...
2017: Theranostics
https://www.readbyqxmd.com/read/28837925/recent-advances-in-signal-amplification-strategy-based-on-oligonucleotide-and-nanomaterials-for-microrna-detection-a-review
#19
REVIEW
Ying-Xu Chen, Ke-Jing Huang, Ke-Xin Niu
MicroRNAs (MiRNAs) play multiple crucial regulating roles in cell which can regulate one third of protein-coding genes. MiRNAs participate in the developmental and physiological processes of human body, while their aberrant adjustment will be more likely to trigger diseases such as cancers, kidney disease, central nervous system diseases, cardiovascular diseases, diabetes, viral infections and so on. What's worse, for the detection of miRNAs, their small size, high sequence similarity, low abundance and difficult extraction from cells impose great challenges in the analysis...
August 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28834285/mirna-signatures-of-insulin-resistance-in-obesity
#20
Angela Jones, Kirsty M Danielson, Miles C Benton, Olivia Ziegler, Ravi Shah, Richard S Stubbs, Saumya Das, Donia Macartney-Coxson
OBJECTIVE: Extracellular microRNAs (miRNAs) represent functional biomarkers for obesity and related disorders; this study investigated plasma miRNAs in insulin resistance phenotypes in obesity. METHODS: One hundred seventy-five miRNAs were analyzed in females with obesity (insulin sensitivity, n = 11; insulin resistance, n = 19; type 2 diabetes, n = 15) and without obesity (n = 12). Correlations between miRNA level and clinical parameters and levels of 15 miRNAs in a murine obesity model were investigated...
August 21, 2017: Obesity
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