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Diabetes mirna

Adriana Ibarra, Begoña Vega-Guedes, Yeray Brito-Casillas, Ana M Wägner
Maternal diabetes is associated with an increased risk of complications for the mother and her offspring. The latter have an increased risk of foetal macrosomia, hypoglycaemia, respiratory distress syndrome, preterm delivery, malformations and mortality but also of life-long development of obesity and diabetes. Epigenetics have been proposed as an explanation for this long-term risk, and microRNAs (miRNAs) may play a role, both in short- and long-term outcomes. Gestation is associated with increasing maternal insulin resistance, as well as β-cell expansion, to account for the increased insulin needs and studies performed in pregnant rats support a role of miRNAs in this expansion...
November 12, 2018: Non-Coding RNA
Maria Consiglia Trotta, Rosa Maisto, Nicola Alessio, Anca Hermenean, Michele D'Amico, Clara Di Filippo
The study explored the anti-hypertrophic effect of the melanocortin MC5R stimulation in H9c2 cardiac myocytes exposed to high glucose. This has been done by using α-MSH and selective MC5R agonists and assessing the expression of GLUT4 and GLUT1 transporters, miR-133 and urotensin receptor levels as a marker of cardiac hypertrophy. The study shows for the first time an up-regulation of MC5R expression levels in H9c2 cardiomyocytes exposed to high glucose medium (33 mM D-glucose) for 48 h, compared to cells grown in normal glucose medium (5...
2018: Frontiers in Physiology
Deyu Huang, LuQing Cui, Saeed Ahmed, Fatima Zainab, Qinghua Wu, Xu Wang, Zonghui Yuan
Several humans' diseases such as; cancer, heart disease, diabetes retain an etiology of epigenetic, and a new therapeutic option termed as "epigenetic therapy" can offer a potential way to treat these diseases. A numbers of epigenetic agents such as; inhibitors of DNA methyltransferase (DNMT) and histone deacetylases (HDACs) have grew an intensive investigation, and many of these agents are currently being tested in a clinical trial, while some of them have been approved for the use by the authorities...
November 5, 2018: Food and Chemical Toxicology
Widet Gallo, Jonathan Lou S Esguerra, Lena Eliasson, Olle Melander
Our aim was to identify serum microRNAs (miRNAs) in healthy humans which associate with future onset of both diabetes mellitus and cardiovascular disease. We performed global profiling of 753 mature human miRNAs in serum of 12 pilot subjects followed by measurement of 47 consistently expressed miRNAs in fasting serum of 553 healthy subjects from the baseline exam (1991-1994) of the population based Malmö Diet and Cancer Study Cardiovascular Cohort (MDC-CC), of whom 140 developed diabetes, and 169 cardiovascular diseases during follow-up...
2018: PloS One
Suzana Ljubojević Hadžavdić, Lucija Bartolić, Mirna Bradamante
Dear Editor,Eosinophilic annular erythema (EAE) is a rare figurate dermatitis of unknown etiology with prominent tissue eosinophilia. A 59-year-old male patient presented with a one-month history of itchy, polycyclic, annular, and partially serpiginous lesions involving the back, the gluteal region, and the extremities (Figure 1, a, b). There was no medical history of drug intake. High potency local steroids and antihistamines were prescribed, but without adequate therapeutic results. Extensive laboratory work-up including serological infectious disease testing was performed and was within normal ranges...
October 2018: Acta Dermatovenerologica Croatica: ADC
Yuejin Li, Le Xiao, Jinyuan Li, Ping Sun, Lei Shang, Jian Zhang, Quan Zhao, Yiming Ouyang, Linhai Li, Kunmei Gong
OBJECTIVE: The incidence of diabetic atherosclerosis (DA) is increasing worldwide. The study aim was to identify differentially expressed microRNAs (DE-miRs) potentially associated with the initiation and/or progression of DA, thereby yielding new insights into this disease. METHODS: Matched iliac artery tissue samples were isolated from 6 male rats with or without DA. The Affymetrix GeneChip microRNA 4.0 Array was used to detect miRs. Differential expression between atherosclerotic group and non-atherosclerotic group samples was analyzed using the Gene-Cloud of Biotechnology Information platform...
November 3, 2018: European Journal of Medical Research
Jasmin Strutz, Silvija Cvitic, Hubert Hackl, Karl Kashofer, Hannah Magdalena Appel, Andrea Thüringer, Gernot Desoye, Pieter Koolwijk, Ursula Hiden
MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes alter miRNA expression. In adults the miRNA transcriptome as well as endothelial function differ between the sexes. Here we hypothesized that metabolic disturbances associated with gestational diabetes (GDM) alter miRNA signatures in feto-placental endothelial cells (fpEC), dependent on fetal sex. We isolated human primary fpEC after normal and GDM-complicated pregnancies with male and female neonates and screened for differential miRNA expression using next generation miRNA sequencing...
November 2, 2018: Clinical Science (1979-)
Candice Johnson, Charles Drummer, Anthony Virtue, Tracy Gao, Susu Wu, Miguel Hernandez, Lexy Singh, Hong Wang, Xiao-Feng Yang
We reported that microRNA-155 (miR-155) deficiency in ApoE-/- mice yields a novel metabolically healthy obese (MHO) model, which exhibits improved atherosclerosis but results in obesity, non-alcoholic fatty liver disease (NAFLD) without insulin resistance. Using experimental data mining approaches combined with experiments, we found that, among 109 miRNAs, miR-155, and miR-221 are significantly modulated in all four hyperlipidemia-related diseases (HRDs), namely atherosclerosis, NAFLD, obesity and type II diabetes (T2DM)...
2018: Frontiers in Physiology
Maryam Honardoost, Farid Keramati, Ehsan Arefian, Samira Mohammadi Yeganeh, Masoud Soleimani
Insulin resistance has been implicated as one of the best predictors for type 2 diabetes. Growing evidence propose the involvement of microRNAs (miRNAs) as short regulatory molecules in modulating and inducing resistance. In this regard, we have investigated the role of three selected miRNAs in insulin resistance development (miR-135, miR-202, and miR-214), via assessing glucose uptake levels in C2C12 and L6 muscle cell lines. Interestingly, miRNA-transfected cells demonstrated a significantly different glucose uptake compared to the positive control cells...
October 28, 2018: Journal of Cellular Biochemistry
Prasanth Puthanveetil
Mitochondrial homeostasis is important for the health and well-being of organ systems and organisms. Mitochondrial dysfunction is known to be the cause and consequence of metabolic diseases, including obesity, diabetes, cancer, neurodegeneration, cerebrovascular, and cardiovascular disease. For cardiovascular tissue, which relies mostly on oxidative phosphorylation, the role of mitochondria is inevitable. Rather than being biomarkers of mitochondrial health, miRNAs are now known as bioregulators of this important feature...
October 24, 2018: Drug Discovery Today
Shyam Sundar Nandi, Hamid Reza Shahshahan, Quanliang Shang, Shelby Kutty, Michael Boska, Paras Kumar Mishra
Diabetic cardiomyopathy is a leading cause of heart failure. Developing a novel therapeutic strategy for diabetic cardiomyopathy and characterizing animal models used for diabetes mellitus (DM) are important. Insulin 2 mutant (Ins2+/- ) Akita is a spontaneous, genetic, mouse model for T1DM, which is relevant to humans. There are contrasting reports on systolic dysfunction and pathological remodeling (hypertrophy and fibrosis) in Akita heart. Here, we used magnetic resonance imaging (MRI) approach, a gold standard reference for evaluating cardiac function, to measure ejection fraction (indicator of systolic dysfunction) in Akita...
2018: Frontiers in Physiology
Pingping Wang, Haidong Wang, Cuihong Li, Xiaozhen Zhang, Xia Xiu, Ping Teng, Zengfang Wang
A number of studies have implicated that microRNAs (miRNAs) play a critical role in the development of gestational diabetes mellitus (GDM). However, the role of miR-657 in GDM remains vague up to date. We aim to investigate the modifying effect of miR-657 on GDM, which will provide new insight into the pathogenesis of GDM and may help to identify new diagnostic or therapeutic targets for GDM. Increased expression of miR-657 but decreased expression of interleukin-37 (IL-37) was observed in patients with GDM...
October 26, 2018: Journal of Cellular Physiology
Soheila Rahmani, Nazila Pour Khalili, Fazlullah Khan, Shokoufeh Hassani, Elmira Ghafour-Boroujerdi, Mohammad Abdollahi
Nowadays endocrine disrupting chemical pollution has become one of the major concerns due to their potential role in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adipocyte and skeletal muscles. Obesity, hepatic steatosis, impaired insulin signaling and pancreatic islet function could be the main results of Bisphenol A exposure...
October 22, 2018: Life Sciences
Jun-Hui Yang, Run-Jiao Zhang, Jia-Jie Lin, Ming-Chao Cao, Qie Wang, Hui-Xian Cui, Shao-Guang Sun, Lei Wang
BACKGROUND/AIMS: The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway plays a protective role in both acute neuronal damage and chronic neurodegeneration-related oxidative stress. Circular RNAs (circRNAs) are involved with various diseases in the central nervous system (CNS). This study aimed to identify the key circRNAs involved in Nrf2-neuroprotection against oxidative stress. METHODS: The differentially expressed circRNAs (DEcircRNAs) in the substantia nigra and corpus striatum between Nrf2 (-/-) and Nrf2 (+/+) mice were identified by microarray analysis...
2018: Cellular Physiology and Biochemistry
Susana Rovira-Llopis, Irene Escribano-Lopez, Noelia Diaz-Morales, Francesca Iannantuoni, Sandra Lopez-Domenech, Isabel Andújar, Ana Jover, Jonay Pantoja, Luis M Pallardo, Celia Bañuls, Victor M Victor
BACKGROUND/AIMS: There is a lack of reliable biological markers for the early diagnosis of diabetic nephropathy (DN) during type 2 diabetes. In this pilot study we aim to assess whether miR-31 levels are modulated by the presence of DN and whether the expression of this miRNA is related to leukocyte-endothelial interactions and inflammation. METHODS: Thirty-one T2D patients were enrolled in this pilot study; 18 with no diabetic complications and 13 with diabetic nephropathy...
2018: Cellular Physiology and Biochemistry
Parul Mehra, Yiru Guo, Yibing Nong, Pawel Lorkiewicz, Marjan Nasr, Qianhong Li, Senthilkumar Muthusamy, James A Bradley, Aruni Bhatnagar, Marcin Wysoczynski, Roberto Bolli, Bradford G Hill
Although cell therapy improves cardiac function after myocardial infarction, highly variable results and limited understanding of the underlying mechanisms preclude its clinical translation. Because many heart failure patients are diabetic, we examined how diabetic conditions affect the characteristics of cardiac mesenchymal cells (CMC) and their ability to promote myocardial repair in mice. To examine how diabetes affects CMC function, we isolated CMCs from non-diabetic C57BL/6J (CMCWT ) or diabetic B6.BKS(D)-Leprdb/J (CMCdb/db ) mice...
October 23, 2018: Basic Research in Cardiology
Dan Ye, Guohua Lou, Tianbao Zhang, Fengqin Dong, Yanning Liu
The aberrant expression of Pknox1 is associated with hepatic glucose and lipid dysmetabolism status of type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanism causing Pknox1 overexpression in this pathological status remains unclear. By using miRNA target prediction programs, we found that the 3'-UTR of the Pknox1 mRNA sequence contains highly conserved target sites of miR-17 family. In a rat model of streptozotocin and high-fat diet-induced T2DM and NAFLD complication, the increased hepatic expression of Pknox1 was consistent with decreased expressions of miR-17 family, especially miR-17 and miR-20a...
December 2018: Journal of Cellular and Molecular Medicine
Madhusmita Rout, Sajitha Lulu S
Discerning the relationship between molecules involved in diseases based on their underlying biological mechanisms is one of the greatest challenges in therapeutic development today. Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, which adversely affects both mothers and offspring during and after pregnancy. We have constructed two datasets of (GDM associated genes from affected mother and placenta to systematically analyze and evaluate their interactions like gene-gene, gene-protein, gene-microRNA (miRNA), gene-transcription factors, and gene-associated diseases to enhance our current knowledge, which may lead to further advancements in disease diagnosis, prognosis, and treatment...
October 18, 2018: Journal of Cellular Biochemistry
He-Nan Liu, Nan-Jue Cao, Xun Li, Wei Qian, Xiao-Long Chen
Diabetic retinopathy (DR) is a progressive microvascular complication associated with diabetes, and remains the leading cause of preventable blindness worldwide. Recent studies have revealed that microRNAs (miRNAs) were involving in the physiological and pathophysiological processes of diabetes and its microvascular and macrovascular complications. The purpose of the current investigation is to identify the candidate miR-211 as a novel biomarker for occurrence and progression of DR in clinical study and experimental research...
November 10, 2018: Biochemical and Biophysical Research Communications
Claudiane Guay, Janine K Kruit, Sophie Rome, Véronique Menoud, Niels L Mulder, Angelika Jurdzinski, Francesca Mancarella, Guido Sebastiani, Alena Donda, Bryan J Gonzalez, Camilla Jandus, Karim Bouzakri, Michel Pinget, Christian Boitard, Pedro Romero, Francesco Dotta, Romano Regazzi
Type 1 diabetes is an autoimmune disease initiated by the invasion of pancreatic islets by immune cells that selectively kill the β cells. We found that rodent and human T lymphocytes release exosomes containing the microRNAs (miRNAs) miR-142-3p, miR-142-5p, and miR-155, which can be transferred in active form to β cells favoring apoptosis. Inactivation of these miRNAs in recipient β cells prevents exosome-mediated apoptosis and protects non-obese diabetic (NOD) mice from diabetes development. Islets from protected NOD mice display higher insulin levels, lower insulitis scores, and reduced inflammation...
October 5, 2018: Cell Metabolism
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