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A M García Vicente, B González García, M Amo-Salas, I García Carbonero, J Cassinello Espinosa, J L Gómez-Aldaraví Gutierrez, L Suarez Hinojosa, Á Soriano Castrejón
AIM: To establish the utility of baseline 18 F-Fluorocholine (FCH) PET/CT and bone scintigraphy (BS) in the outcome prediction of patients with castration-resistant prostate cancer and bone metastases (CRPC-BM) treated with 223 Ra. METHODS: Prospective, multicenter and non-randomized study (ChoPET-Rad study). FCH PET/CT and BS were performed before the initiation of 223 Ra (basal FCH PET/CT and BS). Bone disease was classified attending the number of lesions in baseline BS and PET/CT...
July 13, 2018: Clinical & Translational Oncology
Joana Delgado-Silva, Raquel Fernandes, Inês R Pita, Frederico C Pereira, Milosz Jaguszewski, Juan Luis Gutiérrez-Chico, Teresa Ribeiro-Rodrigues, Henrique Girão, Adam Ioannou, Lino Gonçalves
The purpose of this study was to evaluate the impact of prebifurcation renal denervation in a swine model and assess its safety through optical coherence tomography (OCT). Prebifurcation renal denervation with a multi-electrode catheter was performed in one renal artery of 12 healthy pigs, with the contralateral artery and kidney being used as controls. Angiograms and OCT pullbacks were obtained peri-procedurally and 1 month post procedure. Renal tissue catecholamines were quantified, and the arterial wall and peri-adventitial tissue were analyzed histologically...
July 13, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
José V Gutiérrez-Manzanedo, Florentino Carral San Laureano, Pablo Moreno Vides, Guillermo de Castro-Maqueda, Jorge R Fernández-Santosa, Jesús Gustavo Ponce-González
AIMS: To evaluate the knowledge of teachers in educative public centres (pre-, primary, and secondary schools) about type 1 diabetes (T1D) in the Puerto Real University Hospital area (Cadiz, Spain). METHODS: Descriptive observational study in which 756 teachers' answers on the Test of Diabetes Knowledge for Teachers (TDKT) were analysed. Teachers from 44 educative public centres in the Puerto Real University Hospital area (Cadiz, Spain) were selected by randomized sampling (mean age, 44...
July 10, 2018: Diabetes Research and Clinical Practice
Anna Stedman, Carlos Maluquer de Motes, Sandrine Lesellier, Deanna Dalley, Mark Chambers, Jorge Gutierrez-Merino
BACKGROUND: Bovine tuberculosis (bTB) caused by Mycobacterium bovis is the most serious endemic disease affecting livestock in the UK. The European badger (Meles meles) is the most important wildlife reservoir of bTB transmission to cattle, making eradication particularly difficult. In this respect, oral vaccination with the attenuated M. bovis vaccine Bacillus Calmette-Guerin (BCG) has been suggested as a wide-scale intervention to reduce bTB infection in badgers. However, experimental studies show variable protection...
July 13, 2018: BMC Microbiology
Madeleine D Hunter, Adele Shenoy, Andrew Dwork, Mitchell S V Elkind, Randolph Marshall, Jay P Mohr, Susan Morgello, Jose Gutierrez
OBJECTIVE: To test whether HIV is associated with brain large artery vulnerable intima. DESIGN: Cross-sectional study of autopsied HIV+ cases sex and age-matched to HIV- controls. METHODS: Brain large arteries from 302 autopsied cases (50% HIV+) were evaluated morphometrically for the presence of atherosclerosis, size of necrotic core, and fibrous cap thickness. Intima vulnerability was measured as intima elastolytic score [0-5, based on intimal metalloproteinases (MMP)-2, MMP-3, and MMP-9, and tissue inhibitor for MMP-1 and MMP-2 staining], intima inflammatory score (0-3, based on intimal presence of CD3 and CD68 cells and TNF-α staining), neoangiogenesis (factor VIII staining), and apoptosis (caspase 3 staining)...
July 12, 2018: AIDS
Dimitrios Amaxilatis, Georgios Mylonas, Luis Diez, Evangelos Theodoridis, Verónica Gutiérrez, Luis Muñoz
The adoption of technologies like the IoT in urban environments, together with the intensive use of smartphones, is driving transformation towards smart cities. Under this perspective, Experimentation-as-a-Service within OrganiCity aims to create an experimental facility with technologies, services, and applications that simplify innovation within urban ecosystems. We discuss here tools that facilitate experimentation, implementing ways to organize, execute, and administer experimentation campaigns in a smart city context...
July 2, 2018: Sensors
Maria Berrocal, Isaac Corbacho, Carlos Gutierrez-Merino, Ana M Mata
The phenothiazine methylene blue (MB) is attracting increasing attention because it seems to have beneficial effects in the pathogenesis of Alzheimer's disease (AD). Among other factors, the presence of neuritic plaques of amyloid-β peptide (Aβ) aggregates, neurofibrilar tangles of tau and perturbation of cytosolic Ca2+ are important players of the disease. It has been proposed that MB decreases the formation of neuritic plaques due to Aβ aggregation. However, the molecular mechanism underlying this effect is far from clear...
July 9, 2018: Neuropharmacology
Jorge Ramón Padilla-Gutiérrez, Emmanuel Valdés-Alvarado, Saraí Citlalic Rodríguez-Reyes, Juan Arellano-Martin, Héctor Enrique Flores-Salinas, José Francisco Muñoz Valle, Yeminia Valle
Acute coronary syndrome (ACS) is the leading cause of death in elderly patients worldwide. Due its participation in apoptosis, fibrosis, and angiogenesis, transforming growth factor-β (TGF-β) isoforms had been categorized as risk factors for cardiovascular diseases. However, due their contradictory activities, a cardioprotective role has been suggested. The aim was to measure the plasma levels of TGF-β1, 2, and 3 proteins in patients with ACS. This was a case-control study including 225 subjects. The three activated isoforms were measured in serum using the Bio-Plex Pro TGF-β assay by means of magnetic beads; the fluorescence intensity of reporter signal was read in a Bio-Plex Magpix instrument...
July 12, 2018: Cell Biochemistry and Biophysics
Carral-Santander Irving Enrique, Acón-Ramírez Dhariana, Soberón-Ventura Vidal, Peñaranda-Henao Carlos Felipe, Wheelock-Gutiérrez Lorena, García-Aguirre Gerardo
Purpose: To report the conservative management of a penetrating ocular trauma caused by a nail gun with a six-month follow up. Observations: A 21 year-old healthy female suffered an ocular penetrating trauma with a nail gun. She presented with a metallic foreign body that partially entered her left eye through the nasal sclera via pars plana, 3 mm posterior to the limbus, but did not reach the retina. Surgical removal of the foreign body and closure of the scleral wound, without vitrectomy, was performed 16 h after the injury...
September 2018: American Journal of Ophthalmology Case Reports
Braulio Contreras-Trigo, Víctor Díaz-García, Enrique Guzmán-Gutierrez, Ignacio Sanhueza, Pablo Coelho, Sebastián E Godoy, Sergio Torres, Patricio Oyarzún
Gold nanoparticles (AuNPs) are currently under intense investigation for biomedical and biotechnology applications, thanks to their ease in preparation, stability, biocompatibility, multiple surface functionalities, and size-dependent optical properties. The most commonly used method for AuNP synthesis in aqueous solution is the reduction of tetrachloroauric acid (HAuCl₄) with trisodium citrate. We have observed variations in the pH and in the concentration of the gold colloidal suspension synthesized under standard conditions, verifying a reduction in the reaction yield by around 46% from pH 5...
July 12, 2018: Sensors
Francesc Simo Alari, Israel Gutierrez
A 72-year-old woman with morbid obesity and history of psychosis attended the emergency room due to abdominal pain. CT scan revealed a mesenteric infiltration surrounding a thickened wall bowel agglomeration; inside, a dense 2 cm foreign body with no pneumoperitoneum or peritoneal effusion. Surgery revealed four contained bowel perforations due to a blister pill pack inside the ileum; consequently, a 30 cm bowel resection was performed. Ingestion was restarted on day 2, a superficial wound infection was evacuated on day 4 and the patient was discharged 6 days after surgery...
July 11, 2018: BMJ Case Reports
Eunice López-Fuentes, Grecia Hernández-Hernández, Leonardo Castanedo, Guadalupe Gutiérrez-Escobedo, Katarzyna Oktaba, Alejandro De Las Peñas, Irene Castaño
Adherence, an important virulence factor, is mediated by the EPA (<u>Ep</u>ithelial <u>A</u>dhesin) genes in the opportunistic pathogen Candida glabrata Expression of adhesin-encoding genes requires tight regulation in order to respond to harsh environmental conditions within the host. The majority of EPA genes are localized in subtelomeric regions regulated by subtelomeric silencing, which depends mainly on Rap1 and the Sir proteins. In vitro adhesion to epithelial cells is primarily mediated by Epa1...
July 12, 2018: Genetics
Alberto Megías, Raquel Gómez-Leal, María José Gutiérrez-Cobo, Rosario Cabello, Pablo Fernández-Berrocal
This study aimed to contribute to the understanding of the mechanisms underlying the relationship between aggressive behaviour and individual levels of ability emotional intelligence (EI). Three hundred and ninety-five participants took part in this study. Participants were assessed on ability EI, negative affect (NA), and aggression by the Mayer-Salovey-Caruso Emotional Intelligence Test, the Positive and Negative Affect Schedule, and the Buss-Perry Aggression questionnaires, respectively. The results revealed a negative relationship between aggression and ability EI, but this relationship depended on multiple factors: the type of EI branches and aggression dimensions, the influence of NA, and gender...
May 11, 2018: Psychiatry Research
Dabor Resiere, Hossein Mehdaoui, José María Gutiérrez
No abstract text is available yet for this article.
July 2018: PLoS Neglected Tropical Diseases
Evgeniy Ponomarev, Nicolas Ubrig, Ignacio Gutiérrez-Lezama, Helmuth Berger, Alberto F Morpurgo
Recent technical progress is demonstrating the possibility to stack together virtually any combination of atomically thin crystals of van der Waals bonded compounds to form new types of heterostructures and interfaces. As a result, there is the need to understand at a quantitative level how the interfacial properties are determined by the properties of the constituent 2D materials. We address this problem by studying the transport and opto-electronic response of two different interfaces based on transition metal dichalcogenide monolayers, namely WSe2 /MoSe2 and WSe2 /MoS2 ...
July 12, 2018: Nano Letters
Astrid Pezoa, Pablo Jorquera, Ricardo Madrid, Pamela Maturana, Paola Viviani, Solange Caussade
INTRODUCTION: The prognosis of patients with cystic fibrosis (CF) has remarkably improved. The as sessment of the disease progression is based on the measurement of the FEV1 (Forced Expiratory Volume in one second). OBJECTIVES: 1. To describe forced expiratory flows and volumes and com pare their interpretation according to different reference standards (Knudson, Gutiérrez, and multi ethnic GLI); 2. To describe bronchodilator response. PATIENTS AND METHOD: The medical records and spirometries of all patients with CF controlled at the Dr...
June 2018: Revista Chilena de Pediatría
Cristina Macía-Villa, Sandra Falcao, Marwin Gutierrez, Julio Medina, Hilde Berner Hammer, Eugenio De Miguel
OBJECTIVES: To evaluate by ultrasound (US) the frequency and reliability of peritenon extensor tendon inflammation (PTI) and intra articular synovitis (IAS) in metacarpophalangeal joints (MCPj) of psoriatic arthritis (PsA) patients. METHODS: 27 PsA patients with clinical involvement of MCPj were consecutively included. Presence of PTI and IAS were evaluated by grey-scale (GS) and power Doppler (PD). Longitudinal and transverse 3-5 second videos of US examinations were recorded for reliability assessments by five readers...
June 14, 2018: Clinical and Experimental Rheumatology
Horacio Márquez-González, Mario H Vargas, Lucelli Yáñez-Gutiérrez, Eduardo Almeida-Gutiérrez, Juan Garduño-Espinosa
Objective: Magnetic resonance imaging (MRI) and cardiac catheterization are diagnostic tools for right ventricle dysfunction (RVD), but those are expensive and often unavailable techniques. Thus, our objective was to identify clinical and/or echocardiographic variables capable of predicting a catheterization-based diagnosis of RVD. Design: This was cross-sectional, diagnostic test accuracy study, considering the catheterization-based diagnosis of RVD as the gold standard. Patients: Pediatric patients with non-repaired CHD with overload pressure were evaluated...
2018: Frontiers in Pediatrics
Andres F Gutierrez, Jeffrey W Hoy, Collins A Kimbeng, Niranjan Baisakh
Leaf scald, caused by Xanthomonas albilineans , is a major sugarcane disease worldwide. The disease is managed primarily with resistant cultivars obtained through classical breeding. However, erratic symptom expression hinders the reliability and reproducibility of selection for resistance. The development and use of molecular markers associated with incompatible/compatible reactions could overcome this limitation. The aim of the present work was to find leaf scald resistance-associated molecular markers in sugarcane to facilitate marker-assisted breeding...
2018: Frontiers in Plant Science
Braulio Sánchez-Ureña, Daniel Rojas-Valverde, Randall Gutiérrez-Vargas
Cold water immersion (CWI) has become a highly used recovery method in sports sciences, which seeks to minimize fatigue and accelerate recovery processes; however, tensiomyography (TMG) is a new method to analyze the muscle mechanical response as a recovery indicator after CWI protocols, this relative new tool of muscle function assessment, can lead to new information of understand fatigue recovery trough CWI. The objective of the study was to compare the effect of two CWI protocols, on neuromuscular function recovery...
2018: Frontiers in Physiology
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