keyword
MENU ▼
Read by QxMD icon Read
search

gutierrez

keyword
https://www.readbyqxmd.com/read/29793100/the-still-uncertain-identity-of-the-channel-forming-unit-s-of-the-mitochondrial-permeability-transition-pore
#1
REVIEW
Christopher P Baines, Manuel Gutiérrez-Aguilar
Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually inactive pore responsible for this transition. However, no protein candidate proposed as the actual pore-forming unit has passed rigorous gain- or loss-of-function genetic tests. Here we review evidence for -and against- putative channel-forming components of the MPT pore...
May 16, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29792801/developing-a-novel-sulfoxide-containing-ms-cleavable-homobifunctional-cysteine-reactive-cross-linker-for-studying-protein-protein-interactions
#2
Craig B Gutierrez, Sarah A Block, Clinton Yu, Stephanie M Soohoo, Alexander S Huszagh, Scott D Rychnovsky, Lan Huang
Cross-linking mass spectrometry (XL-MS) has become an emerging technology for defining protein-protein interactions (PPIs) and elucidating architectures of large protein complexes. Up to now, the mostly widely used cross-linking reagents are targeting lysines. While such reagents have been successfully applied to map PPIs at the proteome-wide scale, comprehensive PPI profiling would require additional cross-linking chemistries. Cysteine is one of the most reactive amino acids and an attractive target for cross-linking owing to its unique role in protein structures...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792695/bond-dissociation-energies-of-metallo-supramolecular-building-blocks-insight-from-fragmentation-of-selectively-self-assembled-heterometallic-metallo-supramolecular-aggregates
#3
Yvonne Lorenz, Albert Gutiérrez, Montserrat Ferrer, Marianne Engeser
A series of selectively self-assembled metallo-supramolecular square-like macrocycles with unsymmetric ditopic linkers and two different types of metal corners, i.e., {Pd(η3 -2-Me-C3 H4 )} and {M(dppp)} with dppp = 1,3-bis(diphenylphosphino)propane and M = Pd2+ or Pt2+ , have been studied in the gas phase using collision-induced dissociation. The aggregates show distinct fragmentation patterns determined by ligand length, i.e, aggregate size, and type of metal corner. Information on relative binding strength can be deduced...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792569/the-relationship-between-suicidal-responses-and-traumatic-brain-injury-and-severe-insomnia-in-active-duty-veteran-and-civilian-populations
#4
Kelly A Soberay, Jetta E Hanson, Megan Dwyer, E Ashby Plant, Peter M Gutierrez
OBJECTIVE: This study examined how a positive traumatic brain injury (TBI) screening and insomnia severity relates to suicidal outcomes across active duty, veteran, and civilian samples. METHODS: Data were used from 3,993 participants from 19 studies. We conducted a series of analyses by group to identify which significantly differed on the variables of interest. RESULTS: TBI and insomnia each had independent relationships with outcomes over and above the impact of the other factor...
May 24, 2018: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/29792124/hypersensitivity-to-alemtuzumab-a-safe-and-effective-desensitization-protocol-a-case-report
#5
Diego Gutiérrez-Fernández, Mónica Saldaña-Valderas, Raquel de la Varga-Martínez, Antonio Foncubierta-Fernández, María J Fernández-Anguita, Maria Del C Fernández-Valle, Fermín Medina-Varo
We describe a successful desensitization to alemtuzumab in one patient diagnosed with T-cell prolymphocytic leukaemia. Alemtuzumab treatment was initiated during infusion number 18, the patient showed cutaneous eruption with a miliary pattern, despite premedication with corticosteroids and antihistamines. The eruption returned with successive alemtuzumab infusions (infusions 19, 20 and 21), remained present for longer and was more severe with each infusion. The patient was referred to our Allergy Unit as it was necessary to maintain alemtuzumab treatment...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29791850/the-memory-of-environmental-chemical-exposure-in-c-elegans-is-dependent-on-the-jumonji-demethylases-jmjd-2-and-jmjd-3-utx-1
#6
Jessica Camacho, Lisa Truong, Zeyneb Kurt, Yen-Wei Chen, Marco Morselli, Gerardo Gutierrez, Matteo Pellegrini, Xia Yang, Patrick Allard
How artificial environmental cues are biologically integrated and transgenerationally inherited is still poorly understood. Here, we investigate the mechanisms of inheritance of reproductive outcomes elicited by the model environmental chemical Bisphenol A in C. elegans. We show that Bisphenol A (BPA) exposure causes the derepression of an epigenomically silenced transgene in the germline for 5 generations, regardless of ancestral response. Chromatin immunoprecipitation sequencing (ChIP-seq), histone modification quantitation, and immunofluorescence assays revealed that this effect is associated with a reduction of the repressive marks H3K9me3 and H3K27me3 in whole worms and in germline nuclei in the F3, as well as with reproductive dysfunctions, including germline apoptosis and embryonic lethality...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791413/measurement-of-optical-fiber-parameters-and-thermal-core-diffusion-characteristics-by-digital-image-processing
#7
F Chavez-Gutierrez, A Martinez-Rios, D Toral-Acosta, D Torres-Armenta, J A Guerrero-Viramontes
The simultaneous measurement of the numerical aperture (NA) and mode field diameter (MFD) of single-mode fibers was performed on several commercial fibers by means of digital image processing of the output light projected into a screen. In addition, the changes induced by core diffusion in an ultra-high (UH) NA fiber at several heat depositions from a CO2 laser source were measured. The measurement method was demonstrated to be useful to monitor the adiabaticity of this process, by taking the product of the NA and MFD to verify if it remains constant...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29789758/advantages-of-intraoperative-implant-for-interstitial-brachytherapy-for-accelerated-partial-breast-irradiation-either-frail-patients-with-early-stage-disease-or-in-locally-recurrent-breast-cancer
#8
Salvatore Cozzi, Maria Laplana, Dina Najjari, Andrea Slocker, Xavier Encinas, Joan Pera, Ferran Guedea, Cristina Gutierrez
Purpose: To describe the intraoperative multicatheter implantation technique for accelerated partial breast irradiation (APBI) delivered with high-dose-rate brachytherapy (HDR-BT). Secondarily, to evaluate outcomes and toxicity in a series of 83 patients treated with this technique at our institution. Material and methods: Retrospective analysis of a series of patients treated with HDR-BT APBI after intraoperative multicatheter interstitial implant between November 2006 and June 2017 at our institution...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789737/chilean-atacama-site-imperilled-by-lithium-mining
#9
Jorge S Gutiérrez, Juan G Navedo, Andrea Soriano-Redondo
No abstract text is available yet for this article.
May 2018: Nature
https://www.readbyqxmd.com/read/29789478/strategies-to-improve-activity-recognition-based-on-skeletal-tracking-applying-restrictions-regarding-body-parts-and-similarity-boundaries
#10
Carlos Gutiérrez-López-Franca, Ramón Hervás, Esperanza Johnson
This paper aims to improve activity recognition systems based on skeletal tracking through the study of two different strategies (and its combination): (a) specialized body parts analysis and (b) stricter restrictions for the most easily detectable activities. The study was performed using the Extended Body-Angles Algorithm , which is able to analyze activities using only a single key sample. This system allows to select, for each considered activity, which are its relevant joints , which makes it possible to monitor the body of the user selecting only a subset of the same...
May 22, 2018: Sensors
https://www.readbyqxmd.com/read/29789389/lrrk2-is-a-negative-regulator-of-mycobacterium-tuberculosis-phagosome-maturation-in-macrophages
#11
Anetta Härtlova, Susanne Herbst, Julien Peltier, Angela Rodgers, Orsolya Bilkei-Gorzo, Antony Fearns, Brian D Dill, Heyne Lee, Rowan Flynn, Sally A Cowley, Paul Davies, Patrick A Lewis, Ian G Ganley, Jennifer Martinez, Dario R Alessi, Alastair D Reith, Matthias Trost, Maximiliano G Gutierrez
Mutations in the leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease, chronic inflammation and mycobacterial infections. Although there is evidence supporting the idea that LRRK2 has an immune function, the cellular function of this kinase is still largely unknown. By using genetic, pharmacological and proteomics approaches, we show that LRRK2 kinase activity negatively regulates phagosome maturation via the recruitment of the Class III phosphatidylinositol-3 kinase complex and Rubicon to the phagosome in macrophages...
May 22, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29789363/role-of-severe-acute-respiratory-syndrome-coronavirus-viroporins-e-3a-and-8a-in-replication-and-pathogenesis
#12
Carlos Castaño-Rodriguez, Jose M Honrubia, Javier Gutiérrez-Álvarez, Marta L DeDiego, Jose L Nieto-Torres, Jose M Jimenez-Guardeño, Jose A Regla-Nava, Raul Fernandez-Delgado, Carmina Verdia-Báguena, Maria Queralt-Martín, Grazyna Kochan, Stanley Perlman, Vicente M Aguilella, Isabel Sola, Luis Enjuanes
Viroporins are viral proteins with ion channel (IC) activity that play an important role in several processes, including virus replication and pathogenesis. While many coronaviruses (CoVs) encode two viroporins, severe acute respiratory syndrome CoV (SARS-CoV) encodes three: proteins 3a, E, and 8a. Additionally, proteins 3a and E have a PDZ-binding motif (PBM), which can potentially bind over 400 cellular proteins which contain a PDZ domain, making them potentially important for the control of cell function...
May 22, 2018: MBio
https://www.readbyqxmd.com/read/29789313/blast-xyplot-viewer-a-tool-for-performing-blast-in-whole-genome-sequenced-bacteria-archaea-and-visualize-whole-results-simultaneously
#13
Yagul Pedraza-Pérez, Rodrigo Alberto Cuevas-Vede, Ángel Bernardo Canto-Gómez, Liliana López-Pliego, Rosa María Gutiérrez-Ríos, Ismael Hernández-Lucas, Gustavo Rubín-Linares, Ygnacio Martínez-Laguna, Jesús Francisco López-Olguín, Luis Ernesto Fuentes-Ramírez
One of the most commonly used tools to compare protein or DNA sequences against databases is BLAST. We introduce a web tool that allows the performance of BLAST-searches of protein/DNA sequences in whole-genome sequenced bacteria/archaea, and displays a large amount of BLAST-results simultaneously. The circular bacterial replicons are projected as horizontal lines with fixed length of 360, representing the degrees of a circle. A coordinate system is created with length of the replicon along the x -axis and the number of replicon used on the y -axis...
May 22, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29788075/effects-of-immunonutrition-in-advanced-hiv-disease-a-randomized-placebo-controlled-clinical-trial-promaltia-study
#14
Sergio Serrano-Villar, María de Lagarde, Jorge Vázquez-Castellanos, Alejandro Vallejo, J Ignacio Bernadino, Nadia Madrid, Mariano Matarranz, Alberto Díaz-Santiago, Carolina Gutiérrez, Alfonso Cabello, Judit Villar-García, José Ramón Blanco, Otilia Bisbal, Talía Sainz, Andrés Moya, Santiago Moreno, María José Gosalbes, Vicente Estrada
Background: While nutritional interventions with prebiotics and probiotics seem to exert immunological effects, their clinical implications in HIV-infected subjects initiating ART at advanced HIV disease remain unclear. Methodology: Pilot multicenter randomized, placebo-controlled, double-blind study in which 78 HIV-infected, ART-naive subjects with <350 CD4 T-cells/µl or AIDS were randomized to either daily PMT25341 (a mixture of prebiotics, probiotics, oligonutrients, DHA, EPA, GLA, and aminoacids) or placebo for 48 weeks, each in combination with first-line ART...
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29787419/a-locus-at-7p14-3-predisposes-to-refractory-celiac-disease-progression-from-celiac-disease
#15
Barbara Hrdlickova, Chris J Mulder, Georgia Malamut, Bertrand Meresse, Mathieu Platteel, Yoichiro Kamatani, Isis Ricaño-Ponce, Roy L J van Wanrooij, Maria M Zorro, Marc Jan Bonder, Javier Gutierrez-Achury, Christophe Cellier, Alexandra Zhernakova, Petula Nijeboer, Pilar Galan, Sebo Withoff, Mark Lathrop, Gerd Bouma, Ramnik J Xavier, Bana Jabri, Nadine C Bensussan, Cisca Wijmenga, Vinod Kumar
BACKGROUND: Approximately 5% of patients with celiac disease (CeD) do not respond to a gluten-free diet and progress to refractory celiac disease (RCD), a severe progression that is characterized by infiltration of intraepithelial T lymphocytes. Patients with RCD type II (RCDII) show clonal expansions of intraepithelial T lymphocytes that result in a poor prognosis and a high mortality rate through development of aggressive enteropathy-associated T-cell lymphoma. It is not known whether genetic variations play a role in severe progression of CeD to RCDII...
May 21, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29785440/an-immunoconjugated-up-conversion-nanocomplex-for-selective-imaging-and-photodynamic-therapy-against-her2-positive-breast-cancer
#16
Gonzalo Ramírez-García, Sandeep S Panikar, Tzarara López-Luke, Valeria Piazza, Miguel Angel Honorato-Colin, Tanya Camacho-Villegas, Rodolfo Hernández-Gutiérrez, Elder De la Rosa
Photodynamic therapy represents a very attractive therapeutic tool considered to be effective, minimally invasive and minimally toxic. However, conventional photodynamic therapy actually has two main constraints: the limited penetration depth of visible light needed for its activation, and the lack of selectivity. Considering this, this work reports the synthesis and evaluation of a novel nanoconjugate for imaging and selective photodynamic therapy against HER2-positive breast cancer, a particularly aggressive form of the disease...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29784452/regulation-of-the-oxidative-balance-with-coenzyme-q10-sensitizes-human-glioblastoma-cells-to-radiation-and-temozolomide
#17
Javier Frontiñán-Rubio, Raquel María Santiago-Mora, Consuelo María Nieva-Velasco, Gustavo Ferrín, Alicia Martínez-González, María Victoria Gómez, María Moreno, Julia Ariza, Eva Lozano, Jacinto Arjona-Gutiérrez, Antonio Gil-Agudo, Manuel De la Mata, Milica Pesic, Juan Ramón Peinado, José M Villalba, Luis Pérez-Romasanta, Víctor M Pérez-García, Francisco J Alcaín, Mario Durán-Prado
OBJECTIVES: To investigate how the modulation of the oxidative balance affects cytotoxic therapies in glioblastoma, in vitro. MATERIAL AND METHODS: Human glioblastoma U251 and T98 cells and normal astrocytes C8D1A were loaded with coenzyme Q10 (CoQ). Mitochondrial superoxide ion (O2 - ) and H2 O2 were measured by fluorescence microscopy. OXPHOS performance was assessed in U251 cells with an oxytherm Clark-type electrode. Radio- and chemotherapy cytotoxicity was assessed by immunostaining of γH2AX (24 h), annexin V and nuclei morphology, at short (72 h) and long (15 d) time...
May 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29783705/additive-manufacturing-of-metallic-and-ceramic-components-by-the-material-extrusion-of-highly-filled-polymers-a-review-and-future-perspectives
#18
REVIEW
Joamin Gonzalez-Gutierrez, Santiago Cano, Stephan Schuschnigg, Christian Kukla, Janak Sapkota, Clemens Holzer
Additive manufacturing (AM) is the fabrication of real three-dimensional objects from metals, ceramics, or plastics by adding material, usually as layers. There are several variants of AM; among them material extrusion (ME) is one of the most versatile and widely used. In MEAM, molten or viscous materials are pushed through an orifice and are selectively deposited as strands to form stacked layers and subsequently a three-dimensional object. The commonly used materials for MEAM are thermoplastic polymers and particulate composites; however, recently innovative formulations of highly-filled polymers (HP) with metals or ceramics have also been made available...
May 18, 2018: Materials
https://www.readbyqxmd.com/read/29782406/population-pharmacokinetics-and-pharmacodynamics-of-dexmedetomidine-in-children-undergoing-ambulatory-surgery
#19
María-Gabriela Pérez-Guillé, Alejandra Toledo-López, Liliana Rivera-Espinosa, Radames Alemon-Medina, Chiharu Murata, Ismael Lares-Asseff, Juan Luis Chávez-Pacheco, Josefina Gómez-Garduño, Ana-Lilia Zamora Gutiérrez, Claudia Orozco-Galicia, Karina Ramírez-Morales, Gustavo Lugo-Goytia
BACKGROUND: Dexmedetomidine (DEX) is an α-2 adrenergic agonist with sedative and analgesic properties. Although not approved for pediatric use by the Food and Drug Administration, DEX is increasingly used in pediatric anesthesia and critical care. However, very limited information is available regarding the pharmacokinetics of DEX in children. The aim of this study was to investigate DEX pharmacokinetics and pharmacodynamics (PK-PD) in Mexican children 2-18 years of age who were undergoing outpatient surgical procedures...
May 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29782218/postural-control-and-physiological-responses-to-a-simulated-match-in-u-20-judo-competitors
#20
Luis Santos, Javier Fernández-Río, Eliseo Iglesias-Soler, Miguel Blanco-Traba, Markus Due Jakobsen, Vicente González-Díez, Emerson Franchini, Carlos Gutiérrez, Xurxo Dopico-Calvo, Eduardo Carballeira-Fernández, William Amonette, Oscar Suman
The aim was to evaluate the effects of judo combat on the athletes' postural control (PC) and physiological loading before, during and after a simulated match. Seventeen under-20 regional and national level athletes completed one modified 7-min match. At baseline, during the combat (3rd and 7th minutes) and 2-min post-match centre of pressure (CoP) parameters were assessed. Heart rate (HR), blood lactate (BLa) and rating of perceived exertion (RPE) and local RPE (LRPE) were collected. Significant increments were observed in CoP mean positioning and velocity at 3rd and 7th minutes, but the CoP deviation in both axes was unaffected...
May 21, 2018: Sports Biomechanics
keyword
keyword
108654
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"