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Atahualpa Castillo-Morales, Jimena Monzón-Sandoval, Araxi O Urrutia, Humberto Gutiérrez
Different cell types have different postmitotic maintenance requirements. Nerve cells, however, are unique in this respect as they need to survive and preserve their functional complexity for the entire lifetime of the organism, and failure at any level of their supporting mechanisms leads to a wide range of neurodegenerative conditions. Whether these differences across tissues arise from the activation of distinct cell type-specific maintenance mechanisms or the differential activation of a common molecular repertoire is not known...
October 19, 2018: Neurobiology of Aging
David Gutierrez Blanco, David Romero Funes, Giulio Giambartolomei, Emanuele Lo Menzo, Samuel Szomstein, Raul J Rosenthal
BACKGROUND: There is a paucity of studies comparing risk reduction of the atherosclerotic cardiovascular disease (ASCVD) and Framingham-body mass index (BMI) Coronary Heart risk score after a laparoscopic Roux-en-Y gastric bypass (RYGB), and few studies have assessed the efficacy of laparoscopic sleeve gastrectomy (SG) in reducing cardiovascular risk. OBJECTIVE: Our goal in this study was to compare the impact of SG and RYGB on cardiovascular risk reduction. SETTING: U...
October 9, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Rachel Glicksman, Michelle Ang, Elizabeth Murray, Carina Simniceanu, Elizabeth Lockhart, Julie Gilbert, Eric Gutierrez, Padraig Warde
INTRODUCTION: In 2003/2004 XXX (XXX) divested its assets and staff to regional hospitals, leading to decreased contact between radiotherapy departments across Ontario's Regional Cancer Centres (RCC). The XX (XX) at XXX developed a communities of practice (CoPs) program to re-build the provincial radiotherapy community to facilitate collaboration amongst centres with goals of decreasing variation in practice and improving the quality of patient care. XX's CoPs are led and driven by volunteer front-line healthcare practitioners, who identify and prioritize key quality issues and select corresponding projects to pursue...
November 14, 2018: Practical Radiation Oncology
Wendy Bryan-Quirós, Julián Fernández, José María Gutiérrez, Matthew R Lewin, Bruno Lomonte
A need exists to develop specific and clinically useful inhibitors of toxic enzymes present in snake venoms, responsible for severe tissue damage and life-threatening effects occurring in thousands of people suffering envenomations globally. LY315920 (Varespladib, S-5920, A-001), a low molecular weight drug developed to inhibit several human secreted phospholipases A2 (PLA2 s), was recently shown to also inhibit PLA2 s in whole snake venoms with high potency, yet no studies have examined its direct effect on purified snake venom PLA2 s...
November 14, 2018: Toxicon: Official Journal of the International Society on Toxinology
Gastón Gutiérrez-Gamboa, Encarna Gómez-Plaza, Ana Belén Bautista-Ortín, Teresa Garde-Cerdán, Yerko Moreno-Simunovic, Ana María Martínez-Gil
BACKGROUND: Rootstocks affect vegetative and reproductive parameters of the scion. However, limited knowledge exists on the effects of the adoption of a specific rootstock on grape and wine phenolic composition, which contribute to certain sensory attributes such as color, body and astringency of wine. These compounds are mainly affected by the variety, viticultural management and rootstock. The aim of this work was to study the influence of eight rootstocks on grape anthocyanin content, skin and seed proanthocyanidins and wine chromatic characteristics obtained from Merlot vines...
November 17, 2018: Journal of the Science of Food and Agriculture
Valentín García-Gutiérrez, Dragana Milojkovic, Juan Carlos Hernandez-Boluda, Simone Claudiani, María Luisa Martin Mateos, Luis Felipe Casado-Montero, Gloria González, Antonio Jimenez-Velasco, Concepcion Boque, Alejandra Martinez-Trillos, Isabel Mata Vázquez, Ángel Ramírez Payer, Alicia Senín, Elena Amustio Díez, Abelardo Bárez García, Guiomar Bautista Carrascosa, Guillermo Ortí, Beatriz Cuevas Ruiz, Maria Ángeles Fernández, María Del Carmen García Garay, Pilar Giraldo, Jose María Guinea, Natalia De Las Heras Rodríguez, Nuria Hernán, Ana Iglesias Pérez, Miguel Piris-Villaespesa, Jose Luis López Lorenzo, Josep Maria Martí Martí-Tutusaus, Rolando Omar Vallansot, Fernando Ortega Rivas, Jose Manuel Puerta, Maria Jose Ramirez, Esperanza Romero, Andres Romo, Ana Rosell, Silvanna Saavedra Saavedra, Ana Sebrango, José Tallon, Sandra Valencia, Angeles Portero, Juan Luis Steegmann
Bosutinib is a second-generation tyrosine kinase inhibitor (2GTKI) approved at 400 mg once daily (QD) as first-line therapy in patients with chronic myeloid leukemia (CML) patients and at 500 mg QD in patients who are resistant to or intolerant of prior therapy. In clinical practice, bosutinib is often given to patients who have failed imatinib, nilotinib, and dasatinib (i.e., as fourth-line treatment), despite the limited data on its clinical benefit in this setting. We have retrospectively evaluated the results of bosutinib in a series of 62 CML patients who have failed to prior treatment with all three, imatinib, nilotinib, and dasatinib...
November 16, 2018: Annals of Hematology
Rosalba C García-Méndez, Eduardo Almeida-Gutierrez, Leonor Serrano-Cuevas, Jesús Salvador Sánchez-Díaz, Martín Rosas-Peralta, Jose Alberto Ortega-Ramirez, Jose Antonio Palomo-Villada, Irma Isordia-Salas, Rosa Marisol Alonso-Bravo, Gabriela Borrayo-Sanchez
BACKGROUND: No reflow defined as an altered myocardial reperfusion and failure at microvascular level is a frequent complication in acute myocardial infarction that attenuates beneficial effect of reperfusion therapy leading to poor outcomes. There is not enough evidence to support that previous use of statins improves coronary flow in patients undergoing primary percutaneous coronary intervention (PCI). AIM OF STUDY: To determine if a loading dose of 80 mg of atorvastatin before primary angioplasty reduces the frequency of no reflow, hs-CRP, IL6 intracoronary levels, and major combined cardiovascular events at 30 d...
November 13, 2018: Archives of Medical Research
Haoyang He, Yadira Gutierrez, Thomas M Young, Julie M Schoenung
Chemical hazard assessment (CHA), designed to evaluate the inherent hazard of chemicals used in everyday consumer products, is gaining in popularity and rigor. Although CHA is being more commonly used by industry and government organizations, there is limited information in the academic literature on the merits and limitations of CHA methods. In the current study, the significance of the need to use multiple data sources to successfully complete a CHA is explored. Specifically, a case study approach is used in which more than one hundred organic substances used in the synthesis of organic solar cells are evaluated using the GreenScreen® for Safer Chemicals framework as the basis for the CHA...
October 25, 2018: Journal of Hazardous Materials
Vitor B Rissi, Werner Giehl Glanzner, Mariana Priotto de Macedo, Lady Katerine Serrano Mujica, Karine Campagnolo, Karina Gutierrez, Alessandra Bridi, Hernan Baldassarre, Paulo Bayard Gonçalves, Vilceu Bordignon
Insufficient epigenetic reprogramming is incompatible with normal development of embryos produced by somatic cell nuclear transfer (SCNT), but treatment with histone deacetylases inhibitors (HDACi) enhance development of SCNT embryos. However, the mechanisms underpinning HDACi benefits in SCNT embryos remain largely uncharacterized. We hypothesized that, in addition to enhancing reprogramming, HDACi treatment may promote expression of genes not required for early development of SCNT embryos. To test this hypothesis, RNA synthesis was inhibited by treating bovine SCNT embryos with 5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside (DBR), which were concomitantly treated or not with Scriptaid (Scrip; an HDACi)...
November 1, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
Maria Gabriela Gutierrez de Camargo, Klaus Lunau, Marco Antônio Portugal Luttembarck Batalha, Sebastian Brings, Vinícius Lourenço Garcia de Brito, Leonor Patrícia Cerdeira Morellato
Colour signals are the main floral trait for plant-pollinator communication. Due to visual specificities, flower visitors exert different selective pressures on flower colour signals of plant communities. Although it evolved to attract pollinators, matching their visual sensitivity and colour preferences, floral signals may also evolve to avoid less efficient pollinators and antagonistic flower visitors. We evaluated evidence for the bee avoidance hypothesis in a Neotropical community pollinated mainly by bees and hummingbirds, the campo rupestre...
November 16, 2018: New Phytologist
Victor Jiménez-Yuste, María Teresa Álvarez-Román, Mónica Martín-Salces, Hortensia De la Corte-Rodríguez, Carmen Altisent, Rafael Parra, Ramiro Núñez, Rosario Pérez, Faustino García-Candel, Santiago Bonanad, Felipe Querol, Nieves Alonso, Nuria Fernández-Mosteirín, Elsa López-Ansoar, Luis Javier García-Frade, Nuria Bermejo, Noelia Pérez-González, María José Gutiérrez-Pimentel, Carlo Martinoli, Isabel Fernández-Arias, Hae Kyung Kim
AIM: The use of musculoskeletal ultrasound (MSK-US) following protocols for haemophilic arthropathy and the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score can help standardize monitoring in haemophilia. This study evaluated the joint status (elbows, knees and ankles) of patients with haemophilia B (HB) in Spain using MSK-US and the HEAD-US score. METHODS: Haemophilia B patients ≥14 years old were included in this observational, multicentre, cross-sectional study, regardless of their clinical condition, HB severity and treatment received...
November 16, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
Juan Ignacio González-Montalvo, Coro Mauleón Ladrero, Rocío Menéndez-Colino, Sara Hernández-Gutiérrez, Raquel Ramírez-Martín, Macarena Díaz-de Bustamante, Francisco Sanz Segovia, Francisco Robles Agudo, Teresa Alarcón Alarcón
INTRODUCTION: Hospital occupancy rate by older patients is high, and it will be even higher in the future. Their hospital stay is usually longer, making it important for hospitals to develop structures with the best efficiency possible. METHOD: Hospital discharges of patients older than 75years with the 15 most frequent Diagnosis-Related Groups (DRG) in Geriatrics were recorded during a 5-year period in a 1,200-bed hospital. Length of stay was compared between the two acute geriatric units (AGU), one in the general hospital (GH) and another in an affiliate hospital (AH), as well as with the rest of departments...
November 12, 2018: Revista Española de Geriatría y Gerontología
Oliver Ibarrondo, Isabel Álvarez-López, Frederick Freundlich, Arantzazu Arrospide, Elena Galve-Calvo, María Gutiérrez-Toribio, Arrate Plazaola, Javier Mar
OBJECTIVE: To carry out a cost-utility analysis of the application of the Oncotype genomic test to inform the decision to use or not to use chemotherapy in the Basque Country (Spain). METHOD: The cost-utility study was carried out using a discrete event simulation model representing the natural history of breast cancer. The decision of treatment with chemotherapy based on Oncotype was compared with the standard of treatment based on clinical-pathological criteria...
November 12, 2018: Gaceta Sanitaria
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, Xóchitl Trujillo, Miguel Huerta, José Guzmán-Esquivel, Martha Alicia Higareda-Almaraz, Agustin Lugo-Radillo, Ignacio Moreno-Gutiérrez, Enrique Higareda-Almaraz, Mónica Ríos-Silva
Background: We aimed to screen for depressive mood experienced during acute chikungunya (CHIKV) infection, and to evaluate the association of several exposures with the risk of depressive symptoms. Methods: A cross-sectional analysis of a multicenter cohort study took place and data from 354 adult individuals with confirmed CHIKV infection were analyzed. Participants were recruited in primary health care settings and the Patient Health Questionnaire-2 (PHQ-2) was used. Prevalence odds ratios (OR) and 95% confidence intervals (CIs) estimated by means of logistic models were used...
November 14, 2018: International Journal of Environmental Research and Public Health
Fernando Vaquerizo-Villar, Daniel Alvarez, Leila Kheirandish-Gozal, Gonzalo C Gutierrez-Tobal, Veronica Barroso-Garcia, Andrea Crespo, Felix Del Campo, David Gozal, Roberto Hornero
Pediatric sleep apnea-hypopnea syndrome (SAHS) is a highly prevalent respiratory disorder that may impose many negative effects on the health and development of children. Due to the drawbacks of overnight polysomnography (PSG), the gold standard diagnosis technique, automated analysis of nocturnal oximetry has emerged as a simplified alternative. In order to improve diagnosis ability of oximetry, we propose to evaluate the usefulness of AdaBoost, a classification boosting algorithm, in the context of pediatric SAHS...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Markham H Anderson, Britt W Yazel, Matthew P F Stickle, Fernando D Espinosa Inguez, Nathaniel-Georg S Gutierrez, Malcolm Slaney, Sanjay S Joshi, Lee M Miller
Contemporary hearing aids are markedlylimited in their most important role: improving speech perception in dynamic "cocktail party" environments with multiple, competing talkers. Here we describe an open-source, mobile assistive hearing platform entitled "Cochlearity" which uses eye gaze to guide an acoustic beamformer, so a listener will hear best wherever they look. Cochlearity runs on Android and its eight-channel microphone array can be worn comfortably on the head, e.g. mounted on eyeglasses...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mirza Baig, Farhaan Mirza, Hamid GholamHosseini, Jairo Gutierrez, Ehsan Ullah
Worldwide spending on long-term and chronic care conditions is increasing to a point that requires immediate interventions and advancements to reduce the burden of the healthcare cost. This research is focused on early detection of prediabetes and type 2 diabetes mellitus (T2DM) using wearable technology. An artificial intelligence model was developed based on adaptive-neuro fuzzy interference to detect prediabetes and T2DM via individualized monitoring. The key contributing factors to the proposed model include heart rate, heart rate variability, breathing rate, breathing volume, and activity data (steps, cadence and calories)...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
M Miyagawa, M G F Costa, M A Gutierrez, J P G F Costa, C F F Costa Filho
Lumen segmentation in Optical Coherence Tomography (OCT) images is a very important step to analyze points of interest that may help on atherosclerosis diagnostic and treatment. Past studies use many different methods to segment the lumen in IVOCT images, like level set, morphological reconstruction, Markov random fields, and Otsu binarization. Despite Convolutional Neural Networks (CNN) have shown promising results in the image processing area, we did not identify, in the literature, works applying CNN in IVOCT images...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Niraj Goel, Theodora Chaspari, Bobak J Mortazavi, Temiloluwa Prioleau, Ashutosh Sabharwal, Ricardo Gutierrez-Osuna
Continuous glucose monitoring (CGM) of patients with diabetes allows the effective management of the disease and reduces the risk of hypoglycemic or hyperglycemic episodes. Towards this goal, the development of reliable CGM models is essential for representing the corresponding signals and interpreting them with respect to factors and outcomes of interest. We propose a sparse decomposition model to approximate CGM time-series as a linear combination of a small set of exemplar atoms, appropriately designed through parametric functions to capture the main fluctuations of the CGM signal...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Gonzalo C Gutierrez-Tobal, Leila Kheirandish-Gozal, Fernando Vaquerizo-Villar, Daniel Alvarez, Veronica Barroso-Garcia, Andrea Crespo, Felix Del Campo, David Gozal, Roberto Hornero
This study aims at assessing the bispectral analysis of blood oxygen saturation (SpO2 ) from nocturnal oximetry to help in pediatric sleep apnea-hypopnea syndrome (SAHS) diagnosis. Recent studies have found excessive redundancy in the SAHS-related information usually extracted from SpO2 , while proposing only two features as a reduced set to be used. On the other hand, it has been suggested that SpO2 bispectral analysis is able to provide complementary information to common anthropometric, spectral, and clinical variables...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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