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https://www.readbyqxmd.com/read/30233317/studying-huntington-s-disease-in-yeast-from-mechanisms-to-pharmacological-approaches
#1
REVIEW
Sebastian Hofer, Katharina Kainz, Andreas Zimmermann, Maria A Bauer, Tobias Pendl, Michael Poglitsch, Frank Madeo, Didac Carmona-Gutierrez
Huntington's disease (HD) is a neurodegenerative disorder that leads to progressive neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD remains incurable, and available drugs are effective only for symptomatic management. HD is caused by a mutant form of the huntingtin protein, which harbors an elongated polyglutamine domain and is highly prone to aggregation. However, many aspects underlying the cytotoxicity of mutant huntingtin (mHTT) remain elusive, hindering the efficient development of applicable interventions to counteract HD...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30232499/resource-allocation-optimization-with-multi-trait-genomic-prediction-for-bread-wheat-triticum-aestivum-l-baking-quality
#2
Bettina Lado, Daniel Vázquez, Martin Quincke, Paula Silva, Ignacio Aguilar, Lucia Gutiérrez
Multi-trait genomic prediction models are useful to allocate available resources in breeding programs by targeted phenotyping of correlated traits when predicting expensive and labor-intensive quality parameters. Multi-trait genomic prediction models can be used to predict labor-intensive or expensive correlated traits where phenotyping depth of correlated traits could be larger than phenotyping depth of targeted traits, reducing resources and improving prediction accuracy. This is particularly important in the context of allocating phenotyping resource in plant breeding programs...
September 19, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/30232228/repurposing-ciclopirox-as-a-pharmacological-chaperone-in-a-model-of-congenital-erythropoietic-porphyria
#3
Pedro Urquiza, Ana Laín, Arantza Sanz-Parra, Jorge Moreno, Ganeko Bernardo-Seisdedos, Pierre Dubus, Esperanza González, Virginia Gutiérrez-de-Juan, Sandra García, Hasier Eraña, Itxaso San Juan, Iratxe Macías, Fredj Ben Bdira, Paula Pluta, Gabriel Ortega, Julen Oyarzábal, Rosario González-Muñiz, Juan Rodríguez-Cuesta, Juan Anguita, Emilio Díez, Jean-Marc Blouin, Hubert de Verneuil, José M Mato, Emmanuel Richard, Juan M Falcón-Pérez, Joaquín Castilla, Oscar Millet
Congenital erythropoietic porphyria is a rare autosomal recessive disease produced by deficient activity of uroporphyrinogen III synthase, the fourth enzyme in the heme biosynthetic pathway. The disease affects many organs, can be life-threatening, and currently lacks curative treatments. Inherited mutations most commonly reduce the enzyme's stability, altering its homeostasis and ultimately blunting intracellular heme production. This results in uroporphyrin by-product accumulation in the body, aggravating associated pathological symptoms such as skin photosensitivity and disfiguring phototoxic cutaneous lesions...
September 19, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/30231069/therapeutic-potential-of-extracellular-vesicles-derived-from-human-mesenchymal-stem-cells-in-a-model-of-progressive-multiple-sclerosis
#4
Fernando Laso-García, Jaime Ramos-Cejudo, Francisco Javier Carrillo-Salinas, Laura Otero-Ortega, Ana Feliú, MariCarmen Gómez-de Frutos, Miriam Mecha, Exuperio Díez-Tejedor, Carmen Guaza, María Gutiérrez-Fernández
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication and as possible therapeutic agents in inflammation-mediated demyelinating diseases, including multiple sclerosis (MS). In the present study, we investigated whether intravenously administered EVs derived from mesenchymal stem cells (MSCs) from human adipose tissue might mediate recovery in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease, a progressive model of MS. SJL/J mice were subjected to EV treatment once the disease was established...
2018: PloS One
https://www.readbyqxmd.com/read/30230903/measurement-of-the-soft-drop-jet-mass-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
#5
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, R Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, H Akerstedt, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S C Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, N Anjos, A Annovi, C Antel, M Antonelli, A Antonov, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, M Arik, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, L Asquith, K Assamagan, R Astalos, M Atkinson, N B Atlay, K Augsten, G Avolio, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, J T Baines, M Bajic, O K Baker, P J Bakker, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, A Bandyopadhyay, Sw Banerjee, A A E Bannoura, L Barak, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J T Barkeloo, T Barklow, N Barlow, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, H C Beck, K Becker, M Becker, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, O Beltramello, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, C Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, H Bilokon, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, S Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, M Boehler, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, F M Brochu, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, D Büscher, V Büscher, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, S Cabrera Urbán, D Caforio, H Cai, V M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, M Casolino, D W Casper, R Castelijn, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, S Cheatham, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C Chen, H Chen, J Chen, S Chen, S Chen, X Chen, Y Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, A K Ciftci, D Cinca, V Cindro, I A Cioara, A Ciocio, F Cirotto, Z H Citron, M Citterio, M Ciubancan, A Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, T Colombo, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, G Conti, F Conventi, M Cooke, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, G Costa, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, W A Cribbs, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, J Cummings, M Curatolo, J Cúth, S Czekierda, P Czodrowski, G D'amen, S D'Auria, L D'eramo, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, M F Daneri, N P Dang, A C Daniells, N S Dann, M Danninger, M Dano Hoffmann, V Dao, G Darbo, S Darmora, J Dassoulas, A Dattagupta, T Daubney, W Davey, C David, T Davidek, D R Davis, P Davison, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, R Debbe, C Debenedetti, D V Dedovich, N Dehghanian, I Deigaard, M Del Gaudio, J Del Peso, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Dell'Orso, M Della Pietra, D Della Volpe, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, A Demilly, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, P Dita, S Dita, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, S Donati, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, M Dris, Y Du, J Duarte-Campderros, F Dubinin, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, C Dulsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, S Elles, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, M Ernst, S Errede, M Escalier, C Escobar, B Esposito, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Fakhrutdinov, S Falciano, R J Falla, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, P Fernandez Martinez, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Fischer, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L R Flores Castillo, M J Flowerdew, G T Forcolin, A Formica, F A Förster, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, B Freund, D Froidevaux, J A Frost, C Fukunaga, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, K K Gan, S Ganguly, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, A Gascon Bravo, K Gasnikova, C Gatti, A Gaudiello, G Gaudio, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, G Geßner, S Ghasemi, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, S M Gibson, M Gignac, M Gilchriese, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, C Giuliani, M Giulini, B K Gjelsten, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, R Goncalves Gama, J Goncalves Pinto Firmino Da Costa, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, B Gorini, E Gorini, A Gorišek, A T Goshaw, C Gössling, M I Gostkin, C A Gottardo, C R Goudet, D Goujdami, A G Goussiou, N Govender, E Gozani, I Grabowska-Bold, P O J Gradin, E C Graham, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, C Gray, H M Gray, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, A Grummer, L Guan, W Guan, J Guenther, F Guescini, D Guest, O Gueta, B Gui, E Guido, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, W Guo, Y Guo, R Gupta, S Gurbuz, G Gustavino, B J Gutelman, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A Hamilton, G N Hamity, P G Hamnett, K Han, L Han, S Han, K Hanagaki, K Hanawa, M Hance, D M Handl, B Haney, P Hanke, J B Hansen, J D Hansen, M C Hansen, P H Hansen, K Hara, A S Hard, T Harenberg, F Hariri, S Harkusha, P F Harrison, N M Hartmann, Y Hasegawa, A Hasib, S Hassani, S Haug, R Hauser, L Hauswald, L B Havener, M Havranek, C M Hawkes, R J Hawkings, D Hayden, C P Hays, J M Hays, H S Hayward, S J Haywood, T Heck, V Hedberg, L Heelan, S Heer, K K Heidegger, S Heim, T Heim, B Heinemann, J J Heinrich, L Heinrich, C Heinz, J Hejbal, L Helary, A Held, S Hellman, C Helsens, R C W Henderson, Y Heng, S Henkelmann, A M Henriques Correia, S Henrot-Versille, G H Herbert, H Herde, V Herget, Y Hernández Jiménez, H Herr, G Herten, R Hertenberger, L Hervas, T C Herwig, G G Hesketh, N P Hessey, J W Hetherly, S Higashino, E Higón-Rodriguez, K Hildebrand, E Hill, J C Hill, K H Hiller, S J Hillier, M Hils, I Hinchliffe, M Hirose, D Hirschbuehl, B Hiti, O Hladik, D R Hlaluku, X Hoad, J Hobbs, N Hod, M C Hodgkinson, P Hodgson, A Hoecker, M R Hoeferkamp, F Hoenig, D Hohn, T R Holmes, M Holzbock, M Homann, S Honda, T Honda, T M Hong, B H Hooberman, W H Hopkins, Y Horii, A J Horton, J-Y Hostachy, A Hostiuc, S Hou, A Hoummada, J Howarth, J Hoya, M Hrabovsky, J Hrdinka, I Hristova, J Hrivnac, T Hryn'ova, A Hrynevich, P J Hsu, S-C Hsu, Q Hu, S Hu, Y Huang, Z Hubacek, F Hubaut, F Huegging, T B Huffman, E W Hughes, M Huhtinen, R F H Hunter, P Huo, N Huseynov, J Huston, J Huth, R Hyneman, G Iacobucci, G Iakovidis, I Ibragimov, L Iconomidou-Fayard, Z Idrissi, P Iengo, O Igonkina, T Iizawa, Y Ikegami, M Ikeno, Y Ilchenko, D Iliadis, N Ilic, F Iltzsche, G Introzzi, P Ioannou, M Iodice, K Iordanidou, V Ippolito, M F Isacson, N Ishijima, M Ishino, M Ishitsuka, C Issever, S Istin, F Ito, J M Iturbe Ponce, R Iuppa, H Iwasaki, J M Izen, V Izzo, S Jabbar, P Jackson, R M Jacobs, V Jain, K B Jakobi, K 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van Woerden, M Vanadia, W Vandelli, A Vaniachine, P Vankov, G Vardanyan, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Veeraraghavan, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, H von der Schmitt, E von Toerne, V Vorobel, K Vorobev, M Vos, R Voss, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, J Walder, R Walker, W Walkowiak, V Wallangen, C Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, Q Wang, R-J Wang, R Wang, S M Wang, T Wang, W Wang, W Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, M S Weber, S M Weber, S W Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, J Wotschack, K W Wozniak, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, D Yamaguchi, Y Yamaguchi, A Yamamoto, S Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H Yang, H Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, A Zaman, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, A Zemla, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, D Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, A Zibell, D Zieminska, N I Zimine, C Zimmermann, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, R Zou, M Zur Nedden, L Zwalinski
Jet substructure observables have significantly extended the search program for physics beyond the standard model at the Large Hadron Collider. The state-of-the-art tools have been motivated by theoretical calculations, but there has never been a direct comparison between data and calculations of jet substructure observables that are accurate beyond leading-logarithm approximation. Such observables are significant not only for probing the collinear regime of QCD that is largely unexplored at a hadron collider, but also for improving the understanding of jet substructure properties that are used in many studies at the Large Hadron Collider...
August 31, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/30230476/symbolic-dynamics-to-enhance-diagnostic-ability-of-portable-oximetry-from-the-phone-oximeter-in-the-detection-of-paediatric-sleep-apnoea
#6
Daniel Álvarez, Andrea Crespo, Fernado Vaquerizo-Villar, Gonzalo Cesar Gutierrez-Tobal, Ana Cerezo-Hernández, Verónica Barroso-García, J Mark Ansermino, Guy A Dumont, Roberto Hornero, Felix Del Campo, Ainara Garde
OBJECTIVE: This study is aimed at assessing symbolic dynamics as a reliable technique to characterise complex fluctuations of portable oximetry in the context of automated detection of childhood obstructive sleep apnoea-hypopnoea syndrome (OSAHS). APPROACH: Nocturnal oximetry signals from 142 children with suspected OSAHS were acquired using the Phone Oximeter: a portable device that integrates a pulse oximeter with a smartphone. An apnoea-hypopnoea index (AHI) ≥5 events/h from simultaneous in-lab polysomnography was used to confirm moderate-to-severe childhood OSAHS...
September 19, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/30230467/-usutu-virus-the-phantom-menace
#7
Marion Clé, Sara Salinas, Sylvie Lecollinet, Cécile Beck, Serafin Gutierrez, Thierry Baldet, Philippe Vande Perre, Vincent Foulongne, Yannick Simonin
Usutu virus, an arbovirus discovered in Africa in 1959, has spread over a large part of Europe over the last twenty years causing significant bird mortality as reported in France since 2015. The zoonotic risk, associated with this succession of avian epizootics in Europe, deserves to be taken into account even if human cases remain rare to date. Human infections are most often asymptomatic or present a benign clinical expression. However, neurological complications such as encephalitis or meningoencephalitis have been described...
August 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/30229970/fine-tuning-of-sirt1-expression-is-essential-to-protect-the-liver-from-cholestatic-liver-disease
#8
Britt A Blokker, Monica Maijo, Marta Echeandia, Mikel Galduroz, Angela M Patterson, Anna Ten, Mark Philo, Rebecca Schungel, Virginia Gutierrez-de Juan, Emina Halilbasic, Claudia Fuchs, Gwenaelle Le Gall, Malgorzata Milkiewicz, Piotr Milkiewicz, Jesus M Banales, Simon M Rushbrook, José M Mato, Michael Trauner, Michael Müller, María Luz Martínez-Chantar, Marta Varela-Rey, Naiara Beraza
Cholestasis comprises aetiologically heterogeneous conditions characterized by accumulation of bile acids in the liver that actively contribute to liver damage. Sirtuin 1 (SIRT1) regulates liver regeneration and bile acid metabolism via modulating the farnesoid X receptor (FXR); we here investigate its role in cholestatic liver disease. We determined SIRT1 expression in livers from patients with cholestatic disease, in two experimental models of cholestasis, as well as in human and murine liver cells in response to bile acid loading...
September 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/30229903/pancreatic-cancer-and-autoimmune-diseases-an-association-sustained-by-computational-and-epidemiological-case-control-approaches
#9
Paulina Gomez-Rubio, Janet Piñero, Esther Molina-Montes, Alba Gutiérrez-Sacristán, Mirari Marquez, Marta Rava, Christoph W Michalski, Antoni Farré, Xavier Molero, Matthias Löhr, José Perea, William Greenhalf, Michael O'Rorke, Adonina Tardón, Thomas Gress, Victor M Barberà, Tatjana Crnogorac-Jurcevic, Luís Muñoz-Bellvís, Enrique Domínguez-Muñoz, Joaquim Balsells, Eithne Costello, Jingru Yu, Mar Iglesias, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Josefina Mora, Liam Murray, Damian O'Driscoll, Ignasi Poves, Rita T Lawlor, Weimin Ye, Manuel Hidalgo, Aldo Scarpa, Linda Sharp, Alfredo Carrato, Francisco X Real, Laura I Furlong, Núria Malats
Deciphering the underlying genetic basis behind pancreatic cancer PC and its associated multimorbidities will enhance our knowledge towards PC control. The study investigated the common genetic background of PC and different morbidities through a computational approach and further evaluated the less explored association between PC and autoimmune diseases AIDs through an epidemiological analysis. Gene-disease associations GDAs of 26 morbidities of interest and PC were obtained using the DisGeNET public discovery platform...
September 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30229772/large-amplitude-motions-within-molecules-trapped-in-solid-parahydrogen
#10
Alejandro Gutiérrez-Quintanilla, Michèle Chevalier, Justinas Ceponkus, Rolando R Lozada-García, Jean-Michel Mestdagh, Claudine Crépin
Molecules of the β-diketone and β-dialdehyde families were trapped in solid parahydrogen (pH2) to investigate the vibrational behavior of systems containing an intramolecular hydrogen bond (IHB). In the simplest β-diketone, acetylacetone (AcAc), H transfer related to the IHB is coupled with methyl torsions. In pH2, the study of nuclear spin conversion (NSC) in methyl groups allows the characterisation of the influence of these large amplitude motions on the vibrational modes. The deuteration of the OH group involved in the IHB has important consequences on the vibrational spectrum of the molecule and evidence of NSC in methyl groups is difficult to obtain...
September 19, 2018: Faraday Discussions
https://www.readbyqxmd.com/read/30228947/imids-mobilize-acute-myeloid-leukemia-blasts-to-peripheral-blood-through-downregulation-of-cxcr4-but-fail-to-potentiate-arac-idarubicin-activity-in-preclinical-models-of-non-del5q-5q-aml
#11
Belen Lopez-Millan, Rafael Diaz de la Guardia, Heleia Roca-Ho, Eduardo Anguita, Abul B M M K Islam, Damia Romero-Moya, Cristina Prieto, Francisco Gutierrez-Agüera, Jose Antonio Bejarano-Garcia, Jose Antonio Perez-Simon, Paula Costales, Montse Rovira, Pedro Marín, Silvia Menendez, Mar Iglesias, Jose Luis Fuster, Alvaro Urbano-Ispizua, Fernando Anjos-Afonso, Clara Bueno, Pablo Menendez
Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard chemotherapy based on nucleoside analogs plus anthracyclines. The crosstalk between AML cells and the BM stroma is a major mechanism underlying therapy resistance in AML. Lenalidomide and pomalidomide, a new generation immunomodulatory drugs (IMiDs), possess pleiotropic anti-leukemic properties including potent immune-modulating effects and are commonly used in hematological malignances associated with intrinsic dysfunctional BM such as myelodysplastic syndromes and multiple myeloma...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/30228311/reduction-in-the-levels-of-coq-biosynthetic-proteins-is-related-to-an-increase-in-lifespan-without-evidence-of-hepatic-mitohormesis
#12
María Rodríguez-Hidalgo, Marta Luna-Sánchez, Agustín Hidalgo-Gutiérrez, Eliana Barriocanal-Casado, Cristina Mascaraque, Darío Acuña-Castroviejo, Margarita Rivera, Germaine Escames, Luis C López
Mitohormesis is an adaptive response induced by a mild mitochondrial stress that promotes longevity and metabolic health in different organisms. This mechanism has been proposed as the cause of the increase in the survival in Coq7+/- (Mclk1+/- ) mice, which show hepatic reduction of COQ7, early mitochondrial dysfunction and increased oxidative stress. Our study shows that the lack of COQ9 in Coq9Q95X mice triggers the reduction of COQ7, COQ6 and COQ5, which results in an increase in life expectancy. However, our results reveal that the hepatic CoQ levels are not decreased and, therefore, neither mitochondrial dysfunction or increased oxidative stress are observed in liver of Coq9Q95X mice...
September 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30227934/kinetics-and-pathway-of-biodegradation-of-dibutyl-phthalate-by-pleurotus-ostreatus
#13
Miriam Ahuactzin-Pérez, Saúl Tlécuitl-Beristain, Jorge García-Dávila, Ericka Santacruz-Juárez, Manuel González-Pérez, María Concepción Gutiérrez-Ruíz, Carmen Sánchez
Dibutyl phthalate (DBP) is a plasticizer, whose presence in the environment as a pollutant has attained a great deal of attention due to its reported association with endocrine system disturbances on animals. Growth parameters, glucose uptake, percentage of removal efficiency (%E) of DBP, biodegradation constant of DBP (k) and half-life of DBP biodegradation (t1/2 ) were evaluated for Pleurotus ostreatus grown on media containing glucose and different concentrations of DBP (0, 500 and 1000 mg l-1 ). P. ostreatus degraded 99...
October 2018: Fungal Biology
https://www.readbyqxmd.com/read/30227707/could-fecal-phenylacetic-and-phenylpropionic-acids-be-used-as-indicators-of-health-status
#14
Isabel Gutiérrez-Díaz, Tania Fernández-Navarro, Nuria Salazar, Begoña Bartolome, M Victoria Moreno-Arribas, Patricia López, Ana Suarez, Clara G de Los Reyes-Gavilan, Miguel Gueimonde, Sonia Gonzalez
Although most of the health effects attributed to polyphenols may be linked to their phenolic-derived metabolites, the role of the intestinal derived-phenolics in human health is still far from being well understood. We determined the profile of fecal phenolic-derived metabolites, microbiota, biomarkers of oxidative stress and inflammation, and daily intake of bioactive compounds in 71 elderly volunteers. Phenylacetic and phenylpropionic acids were the main phenolic metabolites present in feces. From them, phenylacetic acid was related with a more pro-oxidant and immune stimulated status, and both were negatively associated with fecal propionate, whereas phenylpropionic acid was directly related with the fecal concentration of acetate...
September 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/30227599/microbiological-changes-during-ripening-of-chihuahua-cheese-manufactured-with-raw-milk-and-its-seasonal-variations
#15
Cristina Sánchez-Gamboa, Liliana Hicks-Pérez, Néstor Gutiérrez-Méndez, Norma Heredia, Santos García, Guadalupe Virginia Nevárez-Moorillón
Chihuahua cheese is a traditional cheese produced in Northwest Mexico that is consumed shortly after production. Cheeses prepared during autumn, winter and summer were collected from five dairies, and analyzed to determine seasonal influence on proximate analysis, texture profile and the microbiological dynamic during a ripening period of 270 days. Coliforms, coagulase-positive staphylococci, molds, yeast, as well as presumptive mesophilic lactobacilli, thermophilic lactobacilli, lactococci, thermophilic cocci and enterococci, were enumerated by plate count on selective agar...
September 17, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/30227274/the-is2-element-improves-transcription-efficiency-of-integration-deficient-lentiviral-vector-episomes
#16
Sabina Sánchez-Hernández, Alejandra Gutierrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierrez, María Tristán-Manzano, Sandra Rodriguez-Perales, Laura Sanchez, Jose Luis Garcia-Perez, Jesus Chato-Astrain, Ricardo Fernandez-Valades, Ana Belén Carrillo-Galvez, Per Anderson, Rosa Montes, Pedro J Real, Francisco Martin, Karim Benabdellah
Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this study, we aimed to improve the expression levels of IDLVs by inserting the IS2 element, which harbors SARs and HS4 sequences, into their LTRs (SE-IS2-IDLVs). Contrary to our expectations, the presence of the IS2 element did not abrogate epigenetic silencing by histone deacetylases...
August 18, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/30226497/-riesgo-de-recurrencia-y-de-nuevas-neoplasias-cut%C3%A3-neas-malignas-en-sujetos-mexicanos-con-carcinoma-basocelular
#17
José F Ruiz-González, Elizabeth Guevara-Gutiérrez, Mercedes Hernández-Torres, Guillermo Solís Ledesma, Alberto Tlacuilo-Parra
Introducción: El carcinoma basocelular (CBC) es la neoplasia cutánea maligna más común. Objetivo: se investigó el riesgo de recurrencia y de nueva neoplasia cutánea maligna después del tratamiento de CBC. Método: Estudio retrospectivo. Fueron identificados los pacientes con diagnóstico histopatológico de CBC primario, de enero de 2007 a diciembre de 2009, y se revisaron los expedientes para investigar el número de recurrencias, la localización, el tipo de tratamiento y la variante histopatológica, determinando nuevas neoplasias cutáneas malignas...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/30226496/-%C3%A3-ndice-de-mannheim-y-mortalidad-en-sepsis-abdominal
#18
Luis G González-Pérez, Yazmín Sánchez-Delgado, Ansony R Godínez-Vidal, José F Cruz-Manzano, Gabriela E Gutiérrez-Uvalle, Noé I Gracida-Mancilla
Introducción: La sepsis abdominal representa la respuesta inflamatoria peritoneal ante la invasión microbiana, con una mortalidad del 17%. El índice de peritonitis de Mannheim es una herramienta clínica y un predictor de mortalidad, con alta sensibilidad y especificidad. Objetivo: Determinar si existe correlación entre el puntaje obtenido mediante el índice de peritonitis de Mannheim y la mortalidad. Método: Estudio retrospectivo, observacional, transversal, durante el periodo entre julio de 2013 y enero de 2014, en pacientes con diagnóstico de sepsis abdominal, en el Hospital General de México Dr...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/30226494/-seguridad-y-eficacia-del-modelo-de-atenci%C3%A3-n-fast-track-vs-atenci%C3%A3-n-convencional-en-apendicitis-no-complicada-del-paciente-pedi%C3%A3-trico
#19
Alberto Tlacuilo-Parra, Sandy P López-Valenzuela, Gabriela Ambriz-González, Elizabeth Guevara-Gutiérrez
Objetivo: Comparar la seguridad y la eficacia de la atención fast-track vs. atención convencional en apendicitis no complicada en un hospital pediátrico. Método: Ensayo clínico controlado, aleatorizado, con dos grupos de 30 pacientes cada uno: A) fast-track, apendicitis no complicada que cumplieron el programa; y B) atención convencional, apendicitis no complicada con atención habitual. Variables de seguridad y eficacia: proporción de complicaciones y tiempo de estancia hospitalaria...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/30225605/high-cardiovascular-risk-patients-benefit-more-from-bariatric-surgery-than-low-cardiovascular-risk-patients
#20
David Gutierrez Blanco, David Romero Funes, Giulio Giambartolomei, Emanuele Lo Menzo, Samuel Szomstein, Raul J Rosenthal
INTRODUCTION: Atherosclerotic cardiovascular disease (ASCVD) and Framingham risk scores (FRS) are used to calculate 10-year risk of coronary death, nonfatal myocardial infarction, or fatal/nonfatal stroke. Our goal is to evaluate the association between preoperative cardiovascular risk and weight loss. METHODS: We retrospectively reviewed bariatric surgeries from 2010 to 2016. Patients who met criteria for calculating 10-year ASCVD score and FRS were included. Data collected included baseline demographics, perioperative parameters, and postoperative outcomes at 12 months...
September 17, 2018: Surgical Endoscopy
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