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Cancer AND NOX

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https://www.readbyqxmd.com/read/27913188/fructose-suppresses-uric-acid-excretion-to-the-intestinal-lumen-as-a-result-of-the-induction-of-oxidative-stress-by-nadph-oxidase-activation
#1
Chihiro Kaneko, Jiro Ogura, Shunichi Sasaki, Keisuke Okamoto, Masaki Kobayashi, Kaori Kuwayama, Katsuya Narumi, Ken Iseki
BACKGROUND: A high intake of fructose increases the risk for hyperuricemia. It has been reported that long-term fructose consumption suppressed renal uric acid excretion and increased serum uric acid level. However, the effect of single administration of fructose on excretion of uric acid has not been clarified. METHODS: We used male Wistar rats, which were orally administered fructose (5g/kg). Those rats were used in each experiment at 12h after administration...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27874952/nox1-promotes-colon-cancer-cell-metastasis-via-activation-of-the-adam17-pathway
#2
H-P Wang, X Wang, L-F Gong, W-J Chen, Z Hao, S-W Feng, Y-B Wu, T Ye, Y-K Cai
OBJECTIVE: Reactive oxygen species (ROS) generated by endogenous metabolic enzymes are involved in a variety of pathology processes, including cancer. In particular, superoxide-generating NADPH oxidase 1 (Nox1), a member of Nox enzyme family, is highly expressed in the colon tissue and has been implicated in physiological and pathophysiological states of colon cancer. However, the underlying molecular mechanism of Nox1 in the regulation of colon cancer progression remains largely unknown...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27869172/a-redox-state-dictated-signalling-pathway-deciphers-the-malignant-cell-specificity-of-cd40-mediated-apoptosis
#3
C J Dunnill, K Ibraheem, A Mohamed, J Southgate, N T Georgopoulos
CD40, a member of the tumour necrosis factor receptor (TNFR) superfamily, has the capacity to cause extensive apoptosis in carcinoma cells, while sparing normal epithelial cells. Yet, apoptosis is only achieved by membrane-presented CD40 ligand (mCD40L), as soluble receptor agonists are but weakly pro-apoptotic. Here, for the first time we have identified the precise signalling cascade underpinning mCD40L-mediated death as involving sequential TRAF3 stabilisation, ASK1 phosphorylation, MKK4 (but not MKK7) activation and JNK/AP-1 induction, leading to a Bak- and Bax-dependent mitochondrial apoptosis pathway...
November 21, 2016: Oncogene
https://www.readbyqxmd.com/read/27862460/intracellular-cysteine-oxidation-is-modulated-by-aquaporin-8-mediated-hydrogen-peroxide-channeling-in-leukaemia-cells
#4
Francesco Vieceli Dalla Sega, Cecilia Prata, Laura Zambonin, Cristina Angeloni, Benedetta Rizzo, Silvana Hrelia, Diana Fiorentini
The modulation of H2 O2 production by NADPH oxidase (Nox), on vascular endothelial growth factor (VEGF) stimulation, affects the redox signaling linked to cancer cell proliferation. H2 O2 signal transduction involves reversible oxidation of thiol proteins, leading to the formation of cysteine sulfenic acids, responsible for the temporary inactivation of many phosphatases. These events imply that H2 O2 reaches its intracellular targets. As Aquaporin-8 (AQP8) has been demonstrated to funnel Nox-produced H2 O2 across the plasma membrane, this study aims to elucidate the role of AQP8 in the redox signaling occurring in human leukaemia B1647 cells that constitutively produce VEGF...
November 15, 2016: BioFactors
https://www.readbyqxmd.com/read/27771433/cells-redox-environment-modulates-brca1-expression-and-dna-homologous-recombination-repair
#5
Aaron Wilson, Vasily A Yakovlev
Cancer development and progression have been linked to oxidative stress, a condition characterized by unbalanced increase in ROS and RNS production. The main endogenous initiators of the redox imbalance in cancer cells are defective mitochondria, elevated NOX activity, and uncoupled NOS3. Traditionally, most attention has been paid to direct oxidative damage to DNA by certain ROS. However, increase in oxidative DNA lesions does not always lead to malignancy. Hence, additional ROS-dependent, pro-carcinogenic mechanisms must be important...
October 19, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27765370/resveratrol-piperine-and-apigenin-differ-in-their-nadph-oxidase-inhibitory-and-reactive-oxygen-species-scavenging-properties
#6
Scott Whitehouse, Pei-Lin Chen, Anna L Greenshields, Mat Nightingale, David W Hoskin, Karen Bedard
BACKGROUND: Many plant-derived chemicals have been studied for their potential benefits in ailments including inflammation, cancer, neurodegeneration, and cardiovascular disease. The health benefits of phytochemicals are often attributed to the targeting of reactive oxygen species (ROS). However, it is not always clear whether these agents act directly as antioxidants to remove ROS, or whether they act indirectly by blocking ROS production by enzymes such as NADPH oxidase (NOX) enzymes, or by influencing the expression of cellular pro- and anti- oxidants...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27756874/mechanism-of-melanoma-cells-selective-apoptosis-induced-by-a-photoactive-nadph-analogue
#7
Florian Rouaud, Jean-Luc Boucher, Anny Slama-Schwok, Stéphane Rocchi
Melanoma is one of the most lethal cancers when it reaches a metastatic stage. Despite the spectacular achievements of targeted therapies (BRAF inhibitors) or immuno-therapies (anti-CTLA4 or anti-PD1), most patients with melanoma will need additional treatments. Here we used a photoactive NADPH analogue called NS1 to induce cell death by inhibition of NADPH oxidases NOX in melanoma cells, including melanoma cells isolated from patients. In contrast, healthy melanocytes growth was unaffected by NS1 treatment...
October 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27694890/an-interaction-between-scribble-and-the-nadph-oxidase-complex-controls-m1-macrophage-polarization-and-function
#8
Weiyue Zheng, Masataka Umitsu, Ishaan Jagan, Charles W Tran, Noboru Ishiyama, Michael BeGora, Kiyomi Araki, Pamela S Ohashi, Mitsuhiko Ikura, Senthil K Muthuswamy
The polarity protein Scribble (SCRIB) regulates apical-basal polarity, directional migration and tumour suppression in Drosophila and mammals. Here we report that SCRIB is an important regulator of myeloid cell functions including bacterial infection and inflammation. SCRIB interacts directly with the NADPH oxidase (NOX) complex in a PSD95/Dlg/ZO-1 (PDZ)-domain-dependent manner and is required for NOX-induced reactive oxygen species (ROS) generation in culture and in vivo. On bacterial infection, SCRIB localized to phagosomes in a leucine-rich repeat-dependent manner and promoted ROS production within phagosomes to kill bacteria...
October 3, 2016: Nature Cell Biology
https://www.readbyqxmd.com/read/27612096/indole-3-carbinol-enhances-sorafenib-cytotoxicity-in-hepatocellular-carcinoma-cells-a-mechanistic-study
#9
Mai M Abdelmageed, Reem N El-Naga, Ebtehal El-Demerdash, Mohamed M Elmazar
Sorafenib is the only chemotherapeutic agent currently approved for unresectable hepatocellular carcinoma (HCC). However, poor response rates have been widely reported. Indole-3-carbinol (I3C) is a potential chemopreventive phytochemical. The present study aimed to explore the potential chemomodulatory effects of I3C on sorafenib in HCC cells as well as the possible underlying mechanisms. I3C exhibited a greater cytotoxicity in HepG2 cells compared to Huh-7 cells (p < 0.0001). Moreover, the co-treatment of HepG2 cells with I3C and sorafenib was more effective (p = 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27600098/inhibition-of-nox1-induces-apoptosis-by-attenuating-the-akt-signaling-pathway-in-oral-squamous-cell-carcinoma-cell-lines
#10
Kunihiro Ito, Akinobu Ota, Takayuki Ono, Toshiki Nakaoka, Md Wahiduzzaman, Sivasundaram Karnan, Hiroyuki Konishi, Akifumi Furuhashi, Tomio Hayashi, Yoichi Yamada, Yoshitaka Hosokawa, Yoshiaki Kazaoka
NADPH oxidases, also known as the Nox family, are major sources of reactive oxygen species generation that regulate redox-sensitive signaling pathways. Recent studies have implicated the Nox family in cancer development and progression. However, the involvement of its members in the development of oral squamous cell carcinoma (OSCC) remains to be elucidated. To clarify this issue, we first analyzed mRNA expression of Nox/Duox family members (Nox1, Nox2, Nox3, Nox4, Nox5, Duox1 and Duox2) in five OSCC cell lines...
September 5, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27576197/gemcitabine-treatment-promotes-pancreatic-cancer-stemness-through-the-nox-ros-nf-%C3%AE%C2%BAb-stat3-signaling-cascade
#11
Zhengle Zhang, Qingke Duan, Hengqiang Zhao, Tao Liu, Heshui Wu, Qiang Shen, Chunyou Wang, Tao Yin
Gemcitabine, the standard chemotherapy drug for advanced pancreatic cancer, has shown limited benefits because of profound chemoresistance. However, the mechanism involved remains unclear. Cancer stem cells exhibit great tumorigenicity and are closely correlated with drug resistance and tumor relapse. In this study, we demonstrated that certain doses of gemcitabine increased the ratios of CD24(+) and CD133(+) cells and the expression of stemness-associated genes such as Bmi1, Nanog, and Sox2. The enhancement of stemness after gemcitabine treatment was accompanied by increased cell migration, chemoresistance, and tumorigenesis...
November 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27533043/silibinin-inhibits-hypoxia-induced-hif-1%C3%AE-mediated-signaling-angiogenesis-and-lipogenesis-in-prostate-cancer-cells-in-vitro-evidence-and-in-vivo-functional-imaging-and-metabolomics
#12
Gagan Deep, Rahul Kumar, Dhanya K Nambiar, Anil K Jain, Anand M Ramteke, Natalie J Serkova, Chapla Agarwal, Rajesh Agarwal
Hypoxia is associated with aggressive phenotype and poor prognosis in prostate cancer (PCa) patients suggesting that PCa growth and progression could be controlled via targeting hypoxia-induced signaling and biological effects. Here, we analyzed silibinin (a natural flavonoid) efficacy to target cell growth, angiogenesis and metabolic changes in human PCa, LNCaP and 22Rv1 cells under hypoxic condition. Silibinin treatment inhibited the proliferation, clonogenicity and endothelial cells tube formation by hypoxic (1% O2 ) PCa cells...
August 17, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27499960/association-between-nadph-oxidase-nox-and-lung-cancer-a-systematic-review-and-meta-analysis
#13
Ming Han, Tianhui Zhang, Lei Yang, Zitong Wang, Junzhong Ruan, Xiujun Chang
BACKGROUND: Lung cancer is a leading cause of death worldwide. Considerable studies have reported that NADPH oxidase (NOX) expression or activity may play an important role in the tumorigenesis of lung cancer. However, the results are inconsistent. Thus, a systematic review and meta-analysis were conducted in this study. METHODS: A systematic search of electronic databases was performed. Statistical analysis was performed using the Comprehensive Meta-Analysis software (Version 3)...
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27477899/reactive-oxygen-species-mediated-synergistic-and-preferential-induction-of-cell-death-and-reduction-of-clonogenic-resistance-in-breast-cancer-cells-by-combined-cisplatin-and-fk228
#14
Lenora Ann Pluchino, Shambhunath Choudhary, Hwa-Chain Robert Wang
Safe and effective combination chemotherapy regimens against breast cancer are lacking. We used our cellular system, consisting of the non-cancerous human breast epithelial MCF10A cell line and its derived tumorigenic, oncogenic H-Ras-expressing, MCF10A-Ras cell line, to investigate the effectiveness of a combination chemotherapy regimen in treating breast cancer cells using two FDA-approved agents, cisplatin and FK228. Cisplatin and FK228 significantly, synergistically, and preferentially induced death and reduced drug resistance of MCF10A-Ras versus MCF10A cells...
October 10, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27472911/long-term-exposure-to-traffic-related-air-pollution-and-risk-of-incident-atrial-fibrillation-a-cohort-study
#15
Maria Monrad, Ahmad Sajadieh, Jeppe Schultz Christensen, Matthias Ketzel, Ole Raaschou-Nielsen, Anne Tjønneland, Kim Overvad, Steffen Loft, Mette Sørensen
BACKGROUND: Atrial fibrillation is the most common sustained arrhythmia and associated with cardiovascular morbidity and mortality. The few studies conducted on short-term effects of air pollution on episodes of atrial fibrillation indicates a positive association, though not consistently. OBJECTIVES: The aim of this study was to evaluate the long-term impact of traffic-related air pollution on incidence of atrial fibrillation in the general population. METHODS: In the Danish Diet, Cancer, and Health cohort of 57,053 people aged 50-64 years at enrolment in 1993-1997, we identified 2,700 cases of first-ever hospital admission for atrial fibrillation from enrolment to end of follow-up in 2011...
July 29, 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27418140/cambogin-exerts-anti-proliferative-and-pro-apoptotic-effects-on-breast-adenocarcinoma-through-the-induction-of-nadph-oxidase-1-and-the-alteration-of-mitochondrial-morphology-and-dynamics
#16
Kaikai Shen, Fangfang Lu, Jianling Xie, Minfeng Wu, Bo Cai, Yurong Liu, Hong Zhang, Hongsheng Tan, Yingyi Pan, Hongxi Xu
Cambogin, a bioactive polycyclic polyprenylated acylphoroglucinol (PPAP) derived from the Garcinia genus, possesses proapoptotic effect in medulloblastoma and breast cancer cells. We have previously demonstrated that the proapoptotic effect of cambogin is driven by the production of reactive oxygen species (ROS). Here we have shown that the inhibitory effect of cambogin on cell proliferation is associated with the loss of mitochondrial transmembrane potential (ΔΨm) and mitochondrial fragmentation. Cambogin also promotes the mutual complex formation of the membrane-bound subunit p22phox of NADPH oxidase 1 (NOX1), as well as the phosphorylation of the cytosolic subunit p47phox, subsequently enhancing membrane-bound NOX1 activity, which leads to increases in intracellular and mitochondrial levels of O2...
July 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27393034/carbon-monoxide-releasing-molecule-2-ameliorates-il-1%C3%AE-induced-il-8-in-human-gastric-cancer-cells
#17
Sen Lian, Yong Xia, Trong Thuan Ung, Pham Ngoc Khoi, Hyun Joong Yoon, Nam Ho Kim, Kyung Keun Kim, Young Do Jung
Carbon monoxide (CO), a byproduct of heme oxygenase (HO), presents antioxidant, anti-inflammatory, and anti-tumor properties. Accumulating evidence supports that interleukin (IL)-8 contribute to the vascularity of human gastric cancer. However, the inhibition of IL-8 expression by CO is yet to be elucidated. Here, we utilized CO releasing molecule-2 (CORM-2) to investigate the effect of CO on IL-1β-induced IL-8 expression and the underlying molecular mechanisms in human gastric cancer AGS cells. CORM-2 dose-dependently suppressed IL-1β-induced IL-8 mRNA and protein expression as well as IL-8 promoter activity...
June 15, 2016: Toxicology
https://www.readbyqxmd.com/read/27345013/fetal-oxidative-stress-mechanisms-of-neurodevelopmental-deficits-and-exacerbation-by-ethanol-and-methamphetamine
#18
REVIEW
Peter G Wells, Shama Bhatia, Danielle M Drake, Lutfiya Miller-Pinsler
In utero exposure of mouse progeny to alcohol (ethanol, EtOH) and methamphetamine (METH) causes substantial postnatal neurodevelopmental deficits. One emerging pathogenic mechanism underlying these deficits involves fetal brain production of reactive oxygen species (ROS) that alter signal transduction, and/or oxidatively damage cellular macromolecules like lipids, proteins, and DNA, the latter leading to altered gene expression, likely via non-mutagenic mechanisms. Even physiological levels of fetal ROS production can be pathogenic in biochemically predisposed progeny, and ROS formation can be enhanced by drugs like EtOH and METH, via activation/induction of ROS-producing NADPH oxidases (NOX), drug bioactivation to free radical intermediates by prostaglandin H synthases (PHS), and other mechanisms...
June 2016: Birth Defects Research. Part C, Embryo Today: Reviews
https://www.readbyqxmd.com/read/27287039/phytanic-acid-activates-nadph-oxidase-through-transactivation-of-epidermal-growth-factor-receptor-in-vascular-smooth-muscle-cells
#19
Gursev S Dhaunsi, Mayra Alsaeid, Saghir Akhtar
BACKGROUND: Phytanic acid (PA) has been implicated in development of cancer and its defective metabolism is known to cause life-threatening conditions, such as Refsum disease, in children. To explore molecular mechanisms of phytanic acid-induced cellular pathology, we investigated its effect on NADPH oxidase (NOX) and epidermal growth factor receptor (EGFR) in rat aortic smooth muscle cells (RASMC). METHODS: Smooth muscle cells were isolated from rat aortae using enzymic digestion with collagenase and elastase...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27282266/nadph-oxidase-1-and-nadph-oxidase-4-have-opposite-prognostic-effects-for-patients-with-hepatocellular-carcinoma-after-hepatectomy
#20
Sang Yun Ha, Yong-Han Paik, Jung Wook Yang, Min Ju Lee, Hyunsik Bae, Cheol-Keun Park
BACKGROUND/AIMS: Nicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated reactive oxygen species contribute to various liver diseases, including hepatocellular carcinoma (HCC). Uncertainties remain regarding the prognostic relevance of NOX1 and NOX4 protein expression in HCC. METHODS: NOX1 and NOX4 protein expression was examined by using immunohistochemistry in tumor tissue from 227 HCC patients who underwent hepatectomy. RESULTS: High immunoreactivity for NOX1 was observed in 197 (86...
September 15, 2016: Gut and Liver
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