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Cancer AND NOX

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https://www.readbyqxmd.com/read/29781053/expression-of-nox-family-genes-and-their-clinical-significance-in-colorectal-cancer
#1
Sang Yeon Cho, Ju Seok Kim, Hyuk Soo Eun, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong, Hee Seok Moon
BACKGROUND: The NADPH oxidase (NOX) family is overexpressed in many cancers and is associated with cancer cell proliferation and metastasis; however, little is known about the role of the NOX family in colorectal cancer (CRC). AIMS: To identify the expression of the NOX family in CRC and to investigate the relationship between the expression of NOXs with the prognosis of the patients. METHODS: In the TCGA data portal, mRNA expression data were obtained from 41 normal samples and 458 CRC samples to analyze mRNA expression and gene alteration...
May 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29696642/air-pollution-and-incidence-of-cancers-of-the-stomach-and-the-upper-aerodigestive-tract-in-the-european-study-of-cohorts-for-air-pollution-effects-escape
#2
Gabriele Nagel, Massimo Stafoggia, Marie Pedersen, Zorana J Andersen, Claudia Galassi, Jule Munkenast, Andrea Jaensch, Johan Sommar, Bertil Forsberg, David Olsson, Bente Oftedal, Norun H Krog, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L Pedersen, Claes-Göran Östenson, Laura Fratiglioni, Mette Sørensen, Anne Tjønneland, Petra H Peeters, Bas Bueno-de-Mesquita, Roel Vermeulen, Marloes Eeftens, Michelle Plusquin, Timothy J Key, Hans Concin, Alois Lang, Meng Wang, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Giulia Cesaroni, Francesco Forastiere, Ibon Tamayo-Uria, Pilar Amiano, Miren Dorronsoro, Kees de Hoogh, Rob Beelen, Paolo Vineis, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen, Gudrun Weinmayr
Air pollution has been classified as carcinogenic to humans. However, to date little is known about the relevance for cancers of the stomach and upper aerodigestive tract (UADT). We investigated the association of long-term exposure to ambient air pollution with incidence of gastric and UADT cancer in 11 European cohorts. Air pollution exposure was assigned by land-use regression models for particulate matter (PM) below 10 µm (PM10 ), below 2.5 µm (PM2.5 ), between 2.5 and 10 µm (PMcoarse ), PM2.5 absorbance and nitrogen oxides (NO2 and NOX ) as well as approximated by traffic indicators...
April 26, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29672044/andrographolide-antagonizes-tnf-%C3%AE-induced-il-8-via-inhibition-of-nadph-oxidase-ros-nf-%C3%AE%C2%BAb-and-src-mapks-ap-1-axis-in-human-colorectal-cancer-hct116-cells
#3
Miaomiao Yuan, Wei Meng, Wenzhen Liao, Sen Lian
Andrographis paniculata Nees is used as a functional food in Japan, Korea, India, and China. Andrographolide, a naturally occurring phytochemical identified in Andrographis paniculata, has been discovered to present anti-inflammatory and anticancer activities. Highly expressed interleukin (IL-8) has been detected in colorectal cancer and is implicated in angiogenesis. However, the effect and molecular mechanisms of IL-8 expression by andrographolide remain obscure in human colorectal cancer cells. The present study was aimed to investigate the effects of andrographolide on TNF-α-induced IL-8 expression and its underlying mechanisms...
May 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29667662/camel-milk-attenuates-methotrexate-induced-kidney-injury-via-activation-of-pi3k-akt-enos-signaling-and-intervention-with-oxidative-aberrations
#4
Hany H Arab, Samir A Salama, Ibrahim A Maghrabi
Methotrexate (MTX) is a classical chemotherapeutic agent with nephrotoxicity as the most disturbing adverse effect. So far, its underlying molecular mechanisms, particularly PI3K/Akt/eNOS transduction, are inadequately explored. Several antioxidant modalities have been characterized to ameliorate MTX-induced renal injury. In this regard, Camel milk (CM) is a natural product with recognized antioxidant and anti-inflammatory features. Thus, the current study aimed to investigate the potential ameliorating effects of CM in MTX-induced kidney injury in rats...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29656218/improved-hypocrellin-a-production-in-shiraia-bambusicola-by-light-dark-shift
#5
Chun Xiao Sun, Yan Jun Ma, Jian Wen Wang
Hypocrellin A (HA) is a major bioactive perylenequinone from the fruiting body of Shiraia bambusicola used for the treatment of skin diseases and developed as a photodynamic therapy (PDT) agent against cancers and viruses. The mycelial culture of S. bambusicola under dark is a biotechnological alternative for HA production but with low yield. In this study, light and dark conditions were investigated to develop effective elicitation on HA production in the cultures. Our results showed the constant light at 200 lx stimulated HA production without any growth retardation of mycelia...
April 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29621558/changes-in-gene-expression-in-lungs-of-mice-exposed-to-traffic-related-air-pollution
#6
Yang Jie, Yi Chen, Zhi Yu, Hui Ding, Zhongfu Ma
Long-term exposure to traffic-related pollutants can lead to a variety of respiratory diseases, including inflammation, asthma, and lung cancer; however, the underlying biological mechanisms are not fully understood. We focused on the effects of exposure to different air pollutants on the expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer. In order to understand the cellular responses induced by exposure to different traffic-related pollutants, we performed PCR array to evaluate the mRNA expression of genes associated with inflammatory immune responses, allergic reactions and asthma, and lung cancer in the lungs of mice exposed to three different environments, including the laboratory (clean air), and polluted parking garages in Foshan and Guangzhou for four weeks...
April 2, 2018: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/29572006/challenges-and-future-direction-of-molecular-research-in-air-pollution-related-lung-cancers
#7
REVIEW
Maizatul Syafinaz Shahadin, Nurul Syakima Ab Mutalib, Mohd Talib Latif, Catherine M Greene, Tidi Hassan
Hazardous air pollutants or chemical release into the environment by a variety of natural and/or anthropogenic activities may give adverse effects to human health. Air pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), carbon monoxide (CO), heavy metals and particulate matter (PM) affect number of different human organs, especially the respiratory system. The International Agency for Research on Cancer (IARC) reported that ambient air pollution is a cause of lung cancer. Recently, the agency has classified outdoor air pollution as well as PM air pollution as Group 1 carcinogens...
April 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29548337/the-interplay-of-reactive-oxygen-species-and-the-epidermal-growth-factor-receptor-in-tumor-progression-and-drug-resistance
#8
REVIEW
Meng-Shih Weng, Jer-Hwa Chang, Wen-Yueh Hung, Yi-Chieh Yang, Ming-Hsien Chien
BACKGROUND: The epidermal growth factor receptor (EGFR) plays important roles in cell survival, growth, differentiation, and tumorigenesis. Dysregulation of the EGFR is a common mechanism in cancer progression especially in non-small cell lung cancer (NSCLC). MAIN BODY: Suppression of the EGFR-mediated signaling pathway is used in cancer treatment. Furthermore, reactive oxygen species (ROS)-induced oxidative stress from mitochondrial dysfunction or NADPH oxidase (NOX) overactivation and ectopic expression of antioxidative enzymes were also indicated to be involved in EGFR-mediated tumor progression (proliferation, differentiation, migration, and invasion) and drug resistance (EGFR tyrosine kinase inhibitor (TKI))...
March 16, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29496628/nox4-driven-ros-formation-regulates-proliferation-and-apoptosis-of-gastric-cancer-cells-through-the-gli1-pathway
#9
Chao-Tao Tang, Xiao-Lu Lin, Shan Wu, Qian Liang, Li Yang, Yun-Jie Gao, Zhi-Zheng Ge
NADPH Oxidase 4 (NOX4), a member of the NOX family, has emerged as a significant source of reactive oxygen species, playing an important role in tumor cell proliferation, apoptosis, and other physiological processes. However, the potential function of NOX4 in gastric cancer (GC) cell proliferation is yet unknown. The aim of this study was to illustrate whether NOX4 plays a role in regulating gastric cancer cell growth. First, the clinical information from 90 patients was utilized to explore the clinical value of NOX4 as a predictive tool for tumor size and prognosis...
June 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29482439/chronic-exposure-to-traffic-related-air-pollution-and-cancer-incidence-among-10-000-patients-undergoing-percutaneous-coronary-interventions-a-historical-prospective-study
#10
Gali Cohen, Ilan Levy, Yuval, Jeremy D Kark, Noam Levin, Guy Witberg, Zaza Iakobishvili, Tamir Bental, David M Broday, David M Steinberg, Ran Kornowski, Yariv Gerber
Background Exposure to traffic-related air pollution (TRAP) is considered to have a carcinogenic effect. The authors previously reported a nonsignificant association between TRAP and cancer risk in a relatively small cohort of myocardial infarction survivors. This study assessed whether TRAP exposure is associated with subsequent cancer in a large cohort of coronary patients. Methods & results Consecutive patients undergoing percutaneous coronary interventions in a major medical centre in central Israel from 2004 to 2014 were followed for cancer through 2015...
April 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29416728/crucial-role-of-pro-inflammatory-cytokines-from-respiratory-tract-upon-pm-2-5-exposure-in-causing-the-bmscs-differentiation-in-cells-and-animals
#11
Xiaoting Jin, Ruijun Su, Ruijin Li, Long Cheng, Zhuoyu Li
Fine particulate matter exposure may cause health risk, including cardiovascular diseases and cancer. Bone marrow mesenchymal stem cell (BMSC), a typical model for evaluating pollutant toxicity, has been closely linked to these diseases, due to its characteristics of differentiation. We therefore studied the BMSCs differentiation and its roles in inflammatory activation in the respiratory tract upon PM2.5 exposure using both in vitro and in vivo models. BMSCs differentiation into endothelial-like cells (ELCs) and cancer-associated fibroblasts cells (CAFs) was enhanced in response to conditioned medium from PM2...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29404504/three-variants-in-the-nicotinamide-adenine-dinucleotide-phosphate-oxidase-complex-are-associated-with-hcv-related-liver-damage
#12
Sandra J Page, Maria M Rivera, David E Kleiner, Xiongce Zhao, Sungyoung Auh, Elaine F Remmers, Theo Heller
Approximately 71 million people are chronically infected with the hepatitis C virus (HCV), a potentially lethal pathogen. HCV generates oxidative stress correlating with disease severity. HCV proteins increase reactive oxygen species production by stimulating nicotinamide adenine dinucleotide phosphate oxidase (NOX) activity. Reactive oxygen species are necessary for host defense and cell signaling; however, elevated NOX activity contributes to cancer, and NOX overexpression is associated with hepatic fibrosis...
November 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29386184/lpa-induces-metabolic-reprogramming-in-ovarian-cancer-via-a-pseudohypoxic-response
#13
Ji Hee Ha, Rangasudhagar Radhakrishnan, Muralidharan Jayaraman, Mingda Yan, Jeremy D Ward, Kar-Ming Fung, Katherine Moxley, Anil K Sood, Ciro Isidoro, Priyabrata Mukherjee, Yong Sang Song, Danny N Dhanasekaran
Although hypoxia has been shown to reprogram cancer cells toward glycolytic shift, the identity of extrinsic stimuli that induce metabolic reprogramming independent of hypoxia, especially in ovarian cancer, is largely unknown. In this study, we use patient-derived ovarian cancer cells and high-grade serous ovarian cancer cell lines to demonstrate that lysophosphatidic acid (LPA), a lipid growth factor and GPCR ligand whose levels are substantially increased in ovarian cancer patients, triggers glycolytic shift in ovarian cancer cells...
April 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29318449/reduction-oxidation-redox-system-in-radiation-induced-normal-tissue-injury-molecular-mechanisms-and-implications-in-radiation-therapeutics
#14
REVIEW
R Yahyapour, E Motevaseli, A Rezaeyan, H Abdollahi, B Farhood, M Cheki, S Rezapoor, D Shabeeb, A E Musa, M Najafi, V Villa
Every year, millions of cancer patients undergo radiation therapy for treating and destroying abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation can have positive therapeutic effects on cancer cells as well as post-detrimental effects on surrounding normal tissues. Previous studies in the past years have proposed that the reduction and oxidation metabolism in cells changes in response to ionizing radiation and has a key role in radiation toxicity to normal tissue. Free radicals generated from ionizing radiation result in upregulation of cyclooxygenases (COXs), nitric oxide synthase (NOSs), lipoxygenases (LOXs) as well as nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), and their effected changes in mitochondrial functions are markedly noticeable...
January 9, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29227990/correction-novel-role-of-nox-in-supporting-aerobic-glycolysis-in-cancer-cells-with-mitochondrial-dysfunction-and-as-a-potential-target-for-cancer-therapy
#15
Weiqin Lu, Yumin Hu, Gang Chen, Zhao Chen, Hui Zhang, Feng Wang, Li Feng, Helene Pelicano, Hua Wang, Michael J Keating, Jinsong Liu, Wallace McKeehan, Huamin Wang, Yongde Luo, Peng Huang
[This corrects the article DOI: 10.1371/journal.pbio.1001326.].
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29142252/gallic-acid-reduces-blood-pressure-and-attenuates-oxidative-stress-and-cardiac-hypertrophy-in-spontaneously-hypertensive-rats
#16
Li Jin, Zhe Hao Piao, Simei Sun, Bin Liu, Gwi Ran Kim, Young Mi Seok, Ming Quan Lin, Yuhee Ryu, Sin Young Choi, Hae Jin Kee, Myung Ho Jeong
Gallic acid (GA) has been reported to have beneficial effects on cancer, vascular calcification, and diabetes-induced myocardial dysfunction. We hypothesized that GA controls hypertension via oxidative stress response regulation in an animal model for essential hypertension. Spontaneously hypertensive rats (SHRs) were administered GA for 16 weeks. GA treatment lowered elevated systolic blood pressure in SHRs through the inhibition of vascular contractility and components of the renin-angiotensin II system. In addition, GA administration reduced aortic wall thickness and body weight in SHRs...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118906/rnai-mediated-silencing-of-nox4-inhibited-the-invasion-of-gastric-cancer-cells-through-jak2-stat3-signaling
#17
Xiang Gao, Jingping Sun, Chunyu Huang, Xiaohua Hu, Ning Jiang, Chenqi Lu
NADPH oxidase 4 (NOX4) is a member of the NADPH oxidase (NOX) family of enzymes and has been found abnormally expressed in human cancers. However, its role in gastric cancer (GC) is still unclear. In the current study, we reported that NOX4 expression levels were significantly up-regulated in GC tissues compared to normal tissues ( P< 0.0001). Higher NOX4 expression was significantly associated with poorer overall survival in GC patients. Silencing NOX4 in two NOX4 high expression GC cell lines, MGC-803 and BGC-823 cells, did not affect cell proliferation, while inhibited cell adhesion and cell invasion of GC cells...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29065504/a-mini-review-of-reactive-oxygen-species-in-urological-cancer-correlation-with-nadph-oxidases-angiogenesis-and-apoptosis
#18
REVIEW
Yasuyoshi Miyata, Tomohiro Matsuo, Yuji Sagara, Kojiro Ohba, Kaname Ohyama, Hideki Sakai
Oxidative stress refers to elevated reactive oxygen species (ROS) levels, and NADPH oxidases (NOXs), which are one of the most important sources of ROS. Oxidative stress plays important roles in the etiologies, pathological mechanisms, and treatment strategies of vascular diseases. Additionally, oxidative stress affects mechanisms of carcinogenesis, tumor growth, and prognosis in malignancies. Nearly all solid tumors show stimulation of neo-vascularity, termed angiogenesis, which is closely associated with malignant aggressiveness...
October 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29048637/leptin-induces-ros-via-nox5-in-healthy-and-neoplastic-mammary-epithelial-cells
#19
Sinda Mahbouli, Audrey Der Vartanian, Sophie Ortega, Stéphanie Rougé, Marie-Paule Vasson, Adrien Rossary
NADPH oxidase (NOX) complexes (a family of seven isoforms) drive cellular ROS production in patho-logical processes such as cancer. NOX-driven ROS production is involved in cell mechanisms from signalling to oxidative stress. Leptin, an adipokine overexpressed in obese patients, has been investigated in studies on breast carcinogenesis, but its effects on oxidative stress remain largely unexplored, especially in breast cancer. The study used three human mammary epithelial cell models presenting different neoplastic status (healthy primary HMECs, neoplastic MCF-7 cells and neoplastic MDA-MB-231 cells) to determine the effects of leptin on short-term ROS production and to characterize the enzymes involved...
September 27, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039574/tgf-%C3%AE-1-induced-cell-migration-in-pancreatic-carcinoma-cells-is-rac1-and-nox4-dependent-and-requires-rac1-and-nox4-dependent-activation-of-p38%C3%A2-mapk
#20
David Witte, Tobias Bartscht, Roland Kaufmann, Ralph Pries, Utz Settmacher, Hendrik Lehnert, Hendrik Ungefroren
Transforming growth factor (TGF)-β promotes epithelial-mesenchymal transition and cell invasion of cancer cells in part through the small GTPase RAC1. Since RAC1 can signal through reactive oxygen species (ROS), we probed the role of the ROS-producing NADPH oxidase (NOX) and p38 mitogen-activated protein kinase (MAPK) in mediating TGF-β1/RAC1-driven random cell migration (chemokinesis). Although the NOX isoforms NOX2, 4, 5, 6, and RAC1 were readily detectable by RT-PCR in pancreatic ductal adenocarcinoma (PDAC)-derived Panc1 and Colo357 cells, only NOX4 and RAC1 were expressed at higher levels comparable to those in peripheral blood monocytes...
October 12, 2017: Oncology Reports
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