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https://www.readbyqxmd.com/read/28894215/gene-expression-of-nox-family-members-and-their-clinical-significance-in-hepatocellular-carcinoma
#1
Hyuk Soo Eun, Sang Yeon Cho, Jong Seok Joo, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex-derived reactive oxygen species (ROS) promote chronic liver inflammation and remodeling that can drive hepatocellular carcinoma development. The role of NOX expression in hepatocellular carcinoma (HCC) has been partially investigated; however, the clinical relevance of collective or individual NOX family member expression for HCC survival remains unclear. Here, we obtained NOX mRNA expression data for 377 HCC samples and 21 normal liver controls from the TCGA data portal and performed Kaplan-Meier survival, gene ontology functional enrichment, and gene set enrichment analyses...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881698/reduction-oxidation-pathways-involved-in-cancer-development-a-systematic-review-of-literature-reviews
#2
REVIEW
Xīn Gào, Ben Schöttker
Oxidative stress results from an imbalance of the reactive oxygen species/reactive nitrogen species (ROS/RNS) production and the oxidants defense system. Extensive research during the last decades has revealed that oxidative stress can mediate cancer initiation and development by leading not only to molecular damage but also to a disruption of reduction-oxidation (redox) signaling. In order to provide a global overview of the redox signaling pathways, which play a role in cancer formation, we conducted a systematic literature search in PubMed and ISI Web of Science and identified 185 relevant reviews published in the last 10 years...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28843141/dna-methylation-and-exposure-to-ambient-air-pollution-in-two-prospective-cohorts
#3
Michelle Plusquin, Florence Guida, Silvia Polidoro, Roel Vermeulen, Ole Raaschou-Nielsen, Gianluca Campanella, Gerard Hoek, Soterios A Kyrtopoulos, Panagiotis Georgiadis, Alessio Naccarati, Carlotta Sacerdote, Vittorio Krogh, H Bas Bueno-de-Mesquita, W M Monique Verschuren, Sergi Sayols-Baixeras, Tommaso Panni, Annette Peters, Dennie G A J Hebels, Jos Kleinjans, Paolo Vineis, Marc Chadeau-Hyam
Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers. However, underlying molecular alterations remain to be further investigated. The aim of this study is to investigate the effects of long-term exposure to air pollutants on (a) average DNA methylation at functional regions and, (b) individual differentially methylated CpG sites. An assumption is that omic measurements, including the methylome, are more sensitive to low doses than hard health outcomes...
August 23, 2017: Environment International
https://www.readbyqxmd.com/read/28827764/traf4-promotes-lung-cancer-aggressiveness-by-modulating-tumor-microenvironment-in-normal-fibroblasts
#4
EunGi Kim, Wanyeon Kim, Sungmin Lee, Jahyun Chun, JiHoon Kang, Gaeul Park, IkJoon Han, Hee Jung Yang, HyeSook Youn, BuHyun Youn
Normal fibroblasts surrounding tumor cells play a crucial role in cancer progression through formation of the tumor microenvironment. Because factors secreted from normal fibroblasts can modulate the tumor microenvironment, it is necessary to identify key factors associated with regulation of secreted factors and to investigate the molecular mechanisms contributing to the tumor microenvironment formation process. In this study, we found that radiation induced the expression and K63-linkage poly-ubiquitination of TRAF4 in normal lung fibroblasts...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28793782/direct-activation-of-nadph-oxidase-2-by-2-deoxyribose-1-phosphate-triggers-nuclear-factor-kappa-b-dependent-angiogenesis
#5
Dina Vara, Joanna M Watt, Tiago M Fortunato, Harry Mellor, Matthew Burgess, Kate Wicks, Kimberly Mace, Shaun Reeksting, Anneke Lubben, Caroline P D Wheeler-Jones, Giordano Pula
AIMS: Deoxyribose-1-phosphate (dRP) is a proangiogenic paracrine stimulus released by cancer cells, platelets, and macrophages and acting on endothelial cells. The objective of this study was to clarify how dRP stimulates angiogenic responses in human endothelial cells. RESULTS: Live cell imaging, electron paramagnetic resonance, pull-down of dRP-interacting proteins, followed by immunoblotting, gene silencing of different NADPH oxidases (NOXs), and their regulatory cosubunits by small interfering RNA (siRNA) transfection, and experiments with inhibitors of the sugar transporter glucose transporter 1 (GLUT1) were utilized to demonstrate that dRP acts intracellularly by directly activating the endothelial NOX2 complex, but not NOX4...
September 18, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28753823/is-there-an-association-between-ambient-air-pollution-and-bladder-cancer-incidence-analysis-of-15-european-cohorts
#6
Marie Pedersen, Massimo Stafoggia, Gudrun Weinmayr, Zorana J Andersen, Claudia Galassi, Johan Sommar, Bertil Forsberg, David Olsson, Bente Oftedal, Norun H Krog, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L Pedersen, Claes-Göran Östenson, Laura Fratiglioni, Mette Sørensen, Kirsten T Eriksen, Anne Tjønneland, Petra H Peeters, Bas Bueno-de-Mesquita, Roel Vermeulen, Marloes Eeftens, Michelle Plusquin, Timothy J Key, Andrea Jaensch, Gabriele Nagel, Hans Concin, Meng Wang, Ming-Yi Tsai, Sara Grioni, Alessandro Marcon, Vittorio Krogh, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Giulia Cesaroni, Francesco Forastiere, Ibon Tamayo, Pilar Amiano, Miren Dorronsoro, Leslie T Stayner, Manolis Kogevinas, Mark J Nieuwenhuijsen, Ranjeet Sokhi, Kees de Hoogh, Rob Beelen, Paolo Vineis, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
BACKGROUND: Ambient air pollution contains low concentrations of carcinogens implicated in the etiology of urinary bladder cancer (BC). Little is known about whether exposure to air pollution influences BC in the general population. OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and BC incidence. DESIGN, SETTING, AND PARTICIPANTS: We obtained data from 15 population-based cohorts enrolled between 1985 and 2005 in eight European countries (N=303431; mean follow-up 14...
November 26, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28746162/lung-cancer-and-annual-mean-exposure-to-outdoor-air-pollution-in-crete-greece
#7
Dimitra Sifaki-Pistolla, Christos Lionis, Filippos Koinis, Vassilis Georgoulias, Nikos Tzanakis
The increasing burden of lung cancer (LC) in Crete, Greece, has raised certain concerns about the potential association of environmental risk factors with LC. The aim of this study was to assess outdoor air pollution (OAP) and the risk for LC mortality for the first time in Crete using LC primary data. 5057 LC cases (diagnosed from 1992 to 2013) were obtained from the Cancer Registry of Crete (http://www.crc.uoc.gr) and followed up until 2014. The age-standardized incidence and mortality rates (ASIR) were calculated...
September 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28736047/health-risk-assessment-as-an-approach-to-manage-an-old-landfill-and-to-propose-integrated-solid-waste-treatment-a-case-study-in-italy
#8
O Paladino, M Massabò
The aim of the present paper is to show how an approach based on human health risk analysis can be used as a decisional tool for the evaluation of impacts on population and for deciding between different waste treatment processes. The situation in which the increasing production of solid wastes cannot be confined in the old existing Municipal Solid Waste landfill (settled in Genoa, Liguria Region, Italy) is used as a case study. Risk assessment for human health due to air, surface water, groundwater and soil contamination is performed in different scenarios for the old landfill and compared with alternative Waste-to-Energy management solutions that consider thermal treatment by gasification of the total waste or gasification of the dry fraction coupled with anaerobic digestion of the wet fraction, plus biogas combustion with or without sludge and bottom ash/slag disposal in the old landfill...
July 21, 2017: Waste Management
https://www.readbyqxmd.com/read/28723216/lycopene-inhibits-metastasis-of-human-liver-adenocarcinoma-sk-hep-1-cells-by-downregulation-of-nadph-oxidase-4-protein-expression
#9
Bo-Yi Jhou, Tuzz-Ying Song, Inn Lee, Miao-Lin Hu, Nae-Cherng Yang
NADPH oxidase 4 (NOX4), with the sole function to produce reactive oxygen species (ROS), can be a molecular target for disrupting cancer metastasis. Several studies have indicated that lycopene exhibited anti-metastatic actions in vitro and in vivo. However, the role of NOX4 in the anti-metastatic action of lycopene remains unknown. Herein, we first confirmed the anti-metastatic effect of lycopene (0.1-5 μM) on human liver adenocarcinoma SK-Hep-1 cells. We showed that lycopene significantly inhibited NOX4 protein expression, with the strongest inhibition of 64...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28709950/characterization-of-potent-and-selective-iodonium-class-inhibitors-of-nadph-oxidases
#10
Jiamo Lu, Prabhakar Risbood, Charles T Kane, Md Tafazzal Hossain, Larry Anderson, Kimberly Hill, Anne Monks, Yongzhong Wu, Smitha Antony, Agnes Juhasz, Han Liu, Guojian Jiang, Erik Harris, Krishnendu Roy, Jennifer L Meitzler, Mariam Konaté, James H Doroshow
The NADPH oxidases (NOXs) play a recognized role in the development and progression of inflammation-associated disorders, as well as cancer. To date, several NOX inhibitors have been developed, through either high throughput screening or targeted disruption of NOX interaction partners, although only a few have reached clinical trials. To improve the efficacy and bioavailability of the iodonium class NOX inhibitor diphenylene iodonium (DPI), we synthesized 36 analogs of DPI, focusing on improved solubility and functionalization...
July 11, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28626501/nadph-oxidases-insights-into-selected-functions-and-mechanisms-of-action-in-cancer-and-stem-cells
#11
REVIEW
Magdalena Skonieczna, Tomasz Hejmo, Aleksandra Poterala-Hejmo, Artur Cieslar-Pobuda, Rafal J Buldak
NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, through tissue regeneration to the development and spread of cancer. In this review, we discuss the roles of NOX and NOX-derived ROS in the functioning of stem cells and cancer stem cells and in selected aspects of cancer cell physiology...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28602912/synthetic-8-hydroxydeoxyguanosine-inhibited-metastasis-of-pancreatic-cancer-through-concerted-inhibitions-of-erm-and-rho-gtpase
#12
Jong-Min Park, Young-Min Han, Migyeong Jeong, Myung Hee Chung, Chang Il Kwon, Kwang Hyun Ko, Ki Baik Hahm
8-hydroxydeoxyguanosine (8-OHdG) is generated consequent to oxidative stress, but its paradoxical anti-oxidative, anti-inflammatory, and anti-mutagenic effects via Rho-GTPase inhibition were noted in various models of inflammation and cancer. Metastasis occurs through cell detachment, epithelial-mesenchymal transition (EMT), and cell migration; during these processes, changes in cell morphology are initiated through Rho-GTPase-dependent actin cytoskeleton polymerization. In this study, we explored the anti-metastatic mechanisms of 8-OHdG in Panc-1 pancreatic cancer cells...
June 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28578276/decoding-nadph-oxidase-4-expression-in-human-tumors
#13
Jennifer L Meitzler, Hala R Makhlouf, Smitha Antony, Yongzhong Wu, Donna Butcher, Guojian Jiang, Agnes Juhasz, Jiamo Lu, Iris Dahan, Pidder Jansen-Dürr, Haymo Pircher, Ajay M Shah, Krishnendu Roy, James H Doroshow
NADPH oxidase 4 (NOX4) is a redox active, membrane-associated protein that contributes to genomic instability, redox signaling, and radiation sensitivity in human cancers based on its capacity to generate H2O2 constitutively. Most studies of NOX4 in malignancy have focused on the evaluation of a small number of tumor cell lines and not on human tumor specimens themselves; furthermore, these studies have often employed immunological tools that have not been well characterized. To determine the prevalence of NOX4 expression across a broad range of solid tumors, we developed a novel monoclonal antibody that recognizes a specific extracellular region of the human NOX4 protein, and that does not cross-react with any of the other six members of the NOX gene family...
May 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/28578013/paradoxical-roles-of-dual-oxidases-in-cancer-biology
#14
REVIEW
Andrew C Little, Arvis Sulovari, Karamatullah Danyal, David E Heppner, David J Seward, Albert van der Vliet
Dysregulated oxidative metabolism is a well-recognized aspect of cancer biology, and many therapeutic strategies are based on targeting cancers by altering cellular redox pathways. The NADPH oxidases (NOXes) present an important enzymatic source of biological oxidants, and the expression and activation of several NOX isoforms are frequently dysregulated in many cancers. Cell-based studies have demonstrated a role for several NOX isozymes in controlling cell proliferation and/or cell migration, further supporting a potential contributing role for NOX in promoting cancer...
September 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28551660/serum-nitric-oxide-as-a-predictive-biomarker-for-bevacizumab-in-non-small-cell-lung-cancer-patients
#15
Satoshi Muto, Hironori Takagi, Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Jun Osugi, Mika Hoshino, Mitsunori Higuchi, Yutaka Shio, Hiroyuki Suzuki
BACKGROUND/AIM: Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Fifteen patients with advanced or recurrent NSCLC treated with bevacizumab-based regimens were evaluated retrospectively. Serum NOx (NO2(-)/NO3(-)) was assayed by the Griess method...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28510506/signaling-at-the-crossroads-matrix-derived-proteoglycan-and-reactive-oxygen-species-signaling
#16
Madalina-Viviana Nastase, Andrea Janicova, Malgorzata Wygrecka, Liliana Schaefer
SIGNIFICANCE: Proteoglycans (PGs), besides their structural contribution, have emerged as dynamic components that mediate a multitude of cellular events. The various roles of PGs are attributed to their structure, spatial localization, and ability to act as ligands and receptors. Reactive oxygen species (ROS) are small mediators, which are generated in physiological and pathological conditions. Besides their reactivity and ability to induce oxidative stress, a growing body of data suggests that ROS signaling is more relevant than direct radical damage in development of human pathologies...
May 16, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28473742/nadph-oxidase-activation-contributes-to-heavy-ion-irradiation-induced-cell-death
#17
Yupei Wang, Qing Liu, Weiping Zhao, Xin Zhou, Guoying Miao, Chao Sun, Hong Zhang
Increased oxidative stress plays an important role in heavy ion radiation-induced cell death. The mechanism involved in the generation of elevated reactive oxygen species (ROS) is not fully illustrated. Here we show that NADPH oxidase activation is closely related to heavy ion radiation-induced cell death via excessive ROS generation. Cell death and cellular ROS can be greatly reduced in irradiated cancer cells with the preincubation of diphenyleneiodium, an inhibitor of NADPH oxidase. Most of the NADPH oxidase (NOX) family proteins (NOX1, NOX2, NOX3, NOX4, and NOX5) showed increased expression after heavy ion irradiation...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28465493/reduction-oxidation-pathways-involved-in-cancer-development-a-systematic-review-of-literature-reviews
#18
REVIEW
Xīn Gào, Ben Schöttker
Oxidative stress results from an imbalance of the reactive oxygen species/reactive nitrogen species (ROS/RNS) production and the oxidants defense system. Extensive research during the last decades has revealed that oxidative stress can mediate cancer initiation and development by leading not only to molecular damage but also to a disruption of reduction-oxidation (redox) signaling. In order to provide a global overview of the redox signaling pathways, which play a role in cancer formation, we conducted a systematic literature search in PubMed and ISI Web of Science and identified 185 relevant reviews published in the last 10 years...
April 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28447737/17%C3%AE-estradiol-protects-against-doxorubicin-induced-cardiotoxicity-in-male-sprague-dawley-rats-by-regulating-nadph-oxidase-and-apoptosis-genes
#19
Xiao-Juan Zhang, Xiao-Qing Cao, Chun-Sheng Zhang, Zhuo Zhao
Doxorubicin (DOX) is one of the most effective chemotherapeutic agents for the treatment of a number of malignancies. However, its use is limited by serious cardiotoxic effects, for which there are currently no reliable pharmacologic therapies. Estrogen has exhibited protective effects against cardiac stressors in male and female animal models; however, its effects on DOX‑induced cardiotoxicity remain unknown. High mortality and morbidity rates have been observed in patients with cancer worldwide, and DOX is often administered to a greater number of men than women...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28441488/formaldehyde-hcho-as-a-hazardous-air-pollutant-mapping-surface-air-concentrations-from-satellite-and-inferring-cancer-risks-in-the-united-states
#20
Lei Zhu, Daniel J Jacob, Frank N Keutsch, Loretta J Mickley, Richard Scheffe, Madeleine Strum, Gonzalo González Abad, Kelly Chance, Kai Yang, Bernhard Rappenglück, Dylan B Millet, Munkhbayar Baasandorj, Lyatt Jaeglé, Viral Shah
Formaldehyde (HCHO) is the most important carcinogen in outdoor air among the 187 hazardous air pollutants (HAPs) identified by the U.S. Environmental Protection Agency (EPA), not including ozone and particulate matter. However, surface observations of HCHO are sparse and the EPA monitoring network could be prone to positive interferences. Here we use 2005-2016 summertime HCHO column data from the OMI satellite instrument, validated with high-quality aircraft data and oversampled on a 5 × 5 km(2) grid, to map surface air HCHO concentrations across the contiguous U...
May 5, 2017: Environmental Science & Technology
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