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Optic coherence tomography optic nerve head in children

Annegret Hella Dahlmann-Noor, Gillian W Adams, Moritz Claudius Daniel, Alison Davis, Joanne Hancox, Melanie Hingorani, Patricia Ibanez, Becky McPhee, Himanshu Patel, Marie Restori, Clare Roberts, Maria Theodorou, James Acheson
BACKGROUND: Following high-profile cases, referrals for evaluation of 'suspicious optic discs' to eye clinics in the UK have sharply increased, asking ophthalmologists to reliably distinguish between true and pseudopapilloedema. Optic nerve sheath dilatation (ONSD) on ocular ultrasound (US) is considered a reliable sign of true papilloedema, but this test is not widely available. Recently, anterior bowing of Bruch's membrane (BM) and increased retinal nerve fibre layer thickness on optical coherence tomography (OCT) have emerged as indicators of intracranial hypertension, and OCT is widely available...
June 21, 2017: British Journal of Ophthalmology
Aubrey L Gilbert, Gena Heidary
PURPOSE OF REVIEW: Papilledema associated with idiopathic intracranial hypertension (IIH) may result in irreversible, progressive visual loss. The development of tools for the evaluation of pediatric patients with IIH is particularly relevant as many patients may not be able to comply with the detailed clinical evaluation utilized in adults for the treatment and management of this disease. The purpose of this review is to summarize relevant articles on the diagnostic tools used in evaluation and management of pediatric IIH...
November 2016: Current Opinion in Ophthalmology
Tom Wright, Ananthavalli Kumarappah, Aphrodite Stavropoulos, Arun Reginald, J Raymond Buncic, Carol A Westall
PURPOSE: The purpose was to determine whether vigabatrin (VGB) (Sabril)-attributed retinal toxicity defined by electroretinogram in early childhood is associated with visual system defect in adolescents after discontinuation of VGB. METHODS: This prospective cross-sectional study included 24 children previously treated with VGB and monitored in early childhood by electroretinogram for VGB-attributed retinal defects. Ten had been diagnosed with VGB-attributed retinal defect (Group I) and 14 had no VGB-attributed retinal defect (Group II)...
May 2017: Retina
Aarti Patel, Ravi Purohit, Helena Lee, Viral Sheth, Gail Maconachie, Eleni Papageorgiou, Rebecca J McLean, Irene Gottlob, Frank A Proudlock
PURPOSE: To determine feasibility of optic nerve head (ONH) imaging and to characterize ONH development in full-term infants without sedation using handheld spectral-domain optical coherence tomography (SD OCT). DESIGN: Prospective cross-sectional study. PARTICIPANTS: Three hundred fifty-two children aged between 1 day and 13 years. METHODS: All participants were imaged using handheld SD OCT without sedation during a single scan session...
October 2016: Ophthalmology
Selim Demir, Samet Özer, Sait Alim, Alper Güneş, Hüseyin Ortak, Resul Yılmaz
AIM: To evaluate retinal nerve fiber layer (RNFL) thickness analysis of peripapillary optic nerve head (PONH) and macula as well as ganglion cell-inner plexiform layer (GCIPL) thickness in obese children. METHODS: Eighty-five children with obesity and 30 controls were included in the study. The thicknesses of the PONH and macula of each subject's right eye were measured by high-resolution spectral-domain optic coherence tomography (OCT). RESULTS: The RNFL thicknesses of central macular and PONH were similar between the groups (all P>0...
2016: International Journal of Ophthalmology
Jared E Duncan, Sharon F Freedman, Mays A El-Dairi
PURPOSE: To evaluate the incidence of visual field defects and choroidal neovascular membranes (CNVM) in a cohort of pediatric patients with optic nerve head drusen (ONHD). METHODS: The medical records of children with ONHD seen at a single center from January 2012 to July 2014 were retrospectively reviewed to identify patients who had a dilated fundus examination, fundus photography, spectral domain optical coherence tomography (SD-OCT)/enhanced-depth imaging (EDI) of the optic nerve head (ONH), SITA fast 24-2 Humphrey visual field (HVF) testing, lumbar puncture, and ocular ultrasound...
February 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Fatma Betül Gürağaç, Yüksel Totan, Emre Güler, Aylin Tenlik, İhsan Gökhan Ertuğrul
PURPOSE: To determine the normative database of macular and retinal nerve fiber layer (RNFL) thickness parameters in healthy Turkish children by OCT. METHODS: 318 eyes of 318 children (138 boys, 183 girls) aged between 3 and 17 years were evaluated. The children were scanned by Cirrus HD-OCT (Carl Zeiss Meditec) to measure the macula, RNFL, and optic nerve head parameters. RESULTS: Axial length (AL) (p < 0.001, R(2 )= 0.08), spherical equivalent (SE) (p < 0...
2017: Seminars in Ophthalmology
Devang L Bhoiwala, John W Simon, Preethi Raghu, Mala Krishnamoorthy, Amit Todani, Sai B Gandham, Steven Simmons
PURPOSE: To expand the normative database of pediatric eyes analyzed with the Optovue optical coherence tomography (OCT). METHODS: In a community-based, cross-sectional analysis, 77 healthy 5-year-old children were recruited from pediatric practices. No subject had any known ocular disorder. Their optic nerves were assessed using Optovue optical coherence tomography (OCT). Data were compared to the normative database obtained by Optovue for adults, ages 18-25, 40-45, and 55-60...
December 2015: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Hae-Young Lopilly Park, Sung Eun Kim, Sung Eum Kim, Chan Kee Park
BACKGROUND: Progressive disc tilting and the development or enlargement of peripapillary atrophy (PPA) are observed during a myopic shift in children. This could be related to the changes around the optic nerve head during eyeball elongation. If the biomechanical properties at or around the optic nerve head are changed after exposure to elevated intraocular pressure (IOP) in glaucoma eyes, different response of the disc tilting and PPA changes could take place during eyeball elongation by myopic shift...
2015: PloS One
Scott A Read, David Alonso-Caneiro, Stephen J Vincent, Michael J Collins
Changes in the thickness of the invivo peripapillary choroid have been documented in a range of ocular conditions in adults; however, choroidal thickness in the peripapillary region of children has not been examined in detail. This study therefore aimed to investigate the thickness of the peripapillary choroid and the overlying retinal nerve fibre layer (RNFL) in a population of normal children with a range of refractive errors. Ninety-three children (37 myopes and 56 non-myopes) aged between 11 and 16 years, had measurements of peripapillary choroidal and RNFL thickness derived from enhanced depth imaging optical coherence tomography images (EDI-OCT, Heidelberg Spectralis)...
June 2015: Experimental Eye Research
J Pacheco-Cervera, P Codoñer-Franch, R Simó-Jordá, S Pons-Vázquez, C Galbis-Estrada, M D Pinazo-Durán
BACKGROUND: Some optic nerve diseases are silent and insidious. Recently, reduced thickness of retinal nerve fibre layer (RNFL) has been associated with increasing body mass index in adults. OBJECTIVES: To investigate the association of childhood obesity with RNFL measured by optical coherence tomography imaging. METHODS: Ninety-seven children aged 5-14 years classified according to standard deviation score of body mass index (SDS-BMI) were included...
December 2015: Pediatric Obesity
Hyo Seok Lee, Sang Woo Park, Hwan Heo
PURPOSE: To compare various optic nerve head (ONH) parameters and peripapillary retinal nerve fibre layer (pRNFL) thickness between megalopapilla cases and normal control using spectral domain optical coherence tomography (SD-OCT) in children. METHODS: Fifty eyes with megalopapilla and 80 normal control eyes of totally 130 children between the ages of 6 and 15 were examined using SD-OCT. Optic nerve head parameters including disc diameter, cup-to-disc ratio, disc area, cup area, rim area, cup volume and rim volume, and pRNFL thickness were analysed and compared between two groups...
June 2015: Acta Ophthalmologica
Amanda L Ely, Mays A El-Dairi, Sharon F Freedman
PURPOSE: To identify optic nerve head (ONH) cupping reversal and associated optical coherence tomography (OCT) and Humphrey visual field changes in pediatric glaucoma. DESIGN: Retrospective observational case series. METHODS: Sequential surgical cases of juvenile open-angle glaucoma (OAG) or primary congenital glaucoma (PCG) with sustained postoperative intraocular pressure (IOP) reduction. Group 1 had preoperative and postoperative ONH photographs and OCT; Group 2 had preoperative clinical ONH assessment and postoperative imaging...
November 2014: American Journal of Ophthalmology
Salem Alshaarawi, Ismail Shatriah, Embong Zunaina, Wan Hazabbah Wan Hitam
BACKGROUND: Variations in optic nerve head morphology and abnormal retinal vascular pattern have been described in preterm children using digital image analysis of fundus photograph, optical coherence tomograph and serial funduscopy. We aimed to compare the optic nerve head parameters in preterm and term Malay children using Heidelberg Retinal Tomograph III. DESIGN: A cross sectional study. METHODOLOGY/PRINCIPAL FINDINGS: Thirty-two preterm Malay children who were born at up to 32 weeks postconception, and 32 term Malay children aged 8-16 years old were recruited into this cross sectional study, which was conducted in the Hospital Universiti Sains Malaysia, Malaysia from January to December 2011...
2014: PloS One
Christiane Al-Haddad, Rafic Antonios, Hani Tamim, Baha' Noureddin
BACKGROUND/AIMS: To report interocular differences in retinal nerve fibre layer (RNFL), optic nerve head and macular parameters in children using spectral domain optical coherence tomography (SD-OCT). METHODS: This was an observational cross-sectional study including 108 healthy children aged 6-17 years with no ocular abnormality except refractive error. After a comprehensive eye exam and axial length measurement, RNFL, optic nerve and macular thickness measurements were performed using the Cirrus OCT machine...
April 2014: British Journal of Ophthalmology
Bi-Dan Zhu, Shi-Ming Li, He Li, Luo-Ru Liu, Yang Wang, Zhou Yang, Si-Yuan Li, Meng-Tian Kang, Jing Fu, Yan-Hua Qi, Si-Yan Zhan, Ningli Wang
PURPOSE: To study the distribution of peripapillary retinal nerve fiber layer (RNFL) thickness in a population of 12-year-old children in central China using iVue-100 spectral-domain optical coherence tomography (SD-OCT). METHODS: Twelve-year-old students (n = 2105) from four randomly selected middle schools in Anyang, China, participated in the study. Each child underwent ocular examinations, including optical biometry, cycloplegic autorefraction, and SD-OCT (iVue-100)...
December 17, 2013: Investigative Ophthalmology & Visual Science
Irene Altemir, Daniel Oros, Noemi Elía, Vicente Polo, Jose M Larrosa, Victoria Pueyo
PURPOSE: To determinate the physiological asymmetry of retinal measurements in the pediatric population with Fourier-domain optical coherence tomography (Cirrus HD-OCT). DESIGN: Prospective cross-sectional study. METHODS: Three hundred and fifty-seven healthy children were recruited. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the retinal nerve fiber layer (RNFL), optic nerve head, and macula with Cirrus OCT...
December 2013: American Journal of Ophthalmology
Rosemarie A Wasmann, Jolien S Klein Wassink-Ruiter, Olof H Sundin, Elisa Morales, Joke B G M Verheij, Jan Willem R Pott
PURPOSE: We present a genetic and clinical analysis of two sisters, 3 and 4 years of age, with nanophthalmos and macular folds. METHODS: Ophthalmological examination, general paediatric examination and molecular genetic analysis of the MFRP gene were performed in both affected siblings. RESULTS: Clinical analysis showed high hyperopia (+11 D and +12 D), short axial lengths (15 mm) and the presence of macular folds and optic nerve head drusen...
May 2014: Acta Ophthalmologica
Sangeetha Srinivasan, Uday K Addepalli, Harsha L Rao, Chandra S Garudadri, Anil K Mandal
AIM: To evaluate optic nerve head, retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness measurements in children operated for primary congenital glaucoma (PCG) using spectral domain optical coherence tomography (SDOCT). METHODS: In a case-control study, 45 eyes of 37 children operated for PCG and 72 eyes of 41 normal children underwent optic nerve head, RNFL and GCC imaging with SDOCT. Differences in SDOCT parameters between PCG and control group, correlation between SDOCT parameters and a range of clinical variables, namely preop corneal diameter, intraocular pressure, degree of corneal oedema and age at which surgery was performed in PCG eyes, were evaluated...
February 2014: British Journal of Ophthalmology
Susana Noval, Josep Visa, Inés Contreras
BACKGROUND: Optic nerve head drusen (ONHD) are deposits due to abnormalities in axonal metabolism and degeneration. Studies so far have focused on adults. Our aim was to study the effect of ONHD on visual function as well as optic nerve head structure using optical coherence tomography (OCT) in children. METHODS: Subjects younger than 18 years of age with ONHD and who had a reliable visual field defect in at least one eye due to ONHD were considered for inclusion...
October 2013: Graefe's Archive for Clinical and Experimental Ophthalmology
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