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Intermittant fasting

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https://www.readbyqxmd.com/read/29146411/metabolic-adaptation-to-intermittent-fasting-is-independent-of-peroxisome-proliferator-activated-receptor-alpha
#1
Guolin Li, Chad N Brocker, Tingting Yan, Cen Xie, Kristopher W Krausz, Rong Xiang, Frank J Gonzalez
BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARA) is a major regulator of fatty acid oxidation and severe hepatic steatosis occurs during acute fasting in Ppara-null mice. Thus, PPARA is considered an important mediator of the fasting response; however, its role in other fasting regiments such as every-other-day fasting (EODF) has not been investigated. METHODS: Mice were pre-conditioned using either a diet containing the potent PPARA agonist Wy-14643 or an EODF regimen prior to acute fasting...
November 6, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29145148/honokiol-protects-pancreatic-%C3%AE-cell-against-high-glucose-and-intermittent-hypoxia-induced-injury-by-activating-nrf2-are-pathway-in-vitro-and-in-vivo
#2
Chen-Guang Li, Chang-Lin Ni, Min Yang, Yun-Zhao Tang, Zhu Li, Yan-Juan Zhu, Zhen-Huan Jiang, Bei Sun, Chun-Jun Li
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Although several studies have revealed that intermittent hypoxia (IH) in OSAHS may further aggravate pancreatic β cell damage and promote the evolution of type 2 diabetes (T2DM) by increasing oxidative stress, the underlying mechanisms are unclear. Honokiol, a potent radical scavenger, has been demonstrated to ameliorate oxidative stress in many cases. The present study aimed to explore the potential mechanism of IH and diabetes synergistically damage and destruct the pancreatic β cell, examine the effects of honokiol on ameliorating pancreatic β cell injury in this context and explore the mechanism of such effects...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29126094/evolutionarily-adapted-hormesis-inducing-stressors-can-be-a-practical-solution-to-mitigate-harmful-effects-of-chronic-exposure-to-low-dose-chemical-mixtures
#3
REVIEW
Se-A Kim, Yu-Mi Lee, Je-Yong Choi, David R Jacobs, Duk-Hee Lee
Although the toxicity of synthetic chemicals at high doses is well known, chronic exposure to low-dose chemical mixtures has only recently been linked to many age-related diseases. However, it is nearly impossible to avoid the exposure to these low-dose chemical mixtures as humans are exposed to a myriad of synthetic chemicals as a part of their daily lives. Therefore, coping with possible harms due to low dose chemical mixtures is challenging. Interestingly, within the range of environmental exposure, disease risk does not increase linearly with increasing dose of chemicals, but often tends to plateau or even decrease with increasing dose...
November 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29124370/popular-weight-loss-strategies-a-review-of-four-weight-loss-techniques
#4
REVIEW
Jonathan Obert, Michelle Pearlman, Lois Obert, Sarah Chapin
PURPOSE OF REVIEW: The purpose of this paper is to review the epidemiology of obesity and the most recent literature on popular fad diets and exercise regimens that are used for weight loss. The weight loss plans that will be discussed in this article include juicing or detoxification diets, intermittent fasting, the paleo diet, and high intensity training. RECENT FINDINGS: Despite the growing popularity of fad diets and exercise plans for weight loss, there are limited studies that actually suggest these particular regimens are beneficial and lead to long-term weight loss...
November 9, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29123880/efficacy-of-direct-hemoperfusion-with-a-polymyxin-b-immobilized-fiber-column-in-miliary-tuberculosis
#5
Yasumasa Kawano, Ryotaro Nagashima, Shinichi Morimoto, Yoshito Izutani, Reiko Yamasaki, Takeshi Nishida, Mitsutoshi Iwaasa, Hiroyasu Ishikura
Case: A 75-year-old woman presented with a 10-day history of intermittent fever, general fatigue, and progressive dyspnea. Although she had a low PaO2/FIO2 ratio, the cause of acute respiratory distress syndrome was not clear until day 9 in hospital. Outcome: We treated the patient with direct hemoperfusion with a polymyxin B-immobilized fiber column incidentally; the PaO2/FIO2 ratio improved following this therapy. Acid-fast bacilli, which were not seen in the sputum on admission, were detected in cultures from sputum, urine, bone marrow, liver biopsy, and blood samples, with a real-time polymerase chain reaction assay confirming tuberculosis...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29117546/intermittent-fasting-promotes-white-adipose-browning-and-decreases-obesity-by-shaping-the-gut-microbiota
#6
Guolin Li, Cen Xie, Siyu Lu, Robert G Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N Brocker, Tingting Yan, Kristopher W Krausz, Rong Xiang, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez
No abstract text is available yet for this article.
November 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29109385/motion-blur-free-high-speed-video-shooting-using-a-resonant-mirror
#7
Michiaki Inoue, Qingyi Gu, Mingjun Jiang, Takeshi Takaki, Idaku Ishii, Kenji Tajima
This study proposes a novel concept of actuator-driven frame-by-frame intermittent tracking for motion-blur-free video shooting of fast-moving objects. The camera frame and shutter timings are controlled for motion blur reduction in synchronization with a free-vibration-type actuator vibrating with a large amplitude at hundreds of hertz so that motion blur can be significantly reduced in free-viewpoint high-frame-rate video shooting for fast-moving objects by deriving the maximum performance of the actuator...
October 29, 2017: Sensors
https://www.readbyqxmd.com/read/29107506/dietary-restriction-and-ampk-increase-lifespan-via-mitochondrial-network-and-peroxisome-remodeling
#8
Heather J Weir, Pallas Yao, Frank K Huynh, Caroline C Escoubas, Renata L Goncalves, Kristopher Burkewitz, Raymond Laboy, Matthew D Hirschey, William B Mair
Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic flexibility. Aging is associated with a loss of mitochondrial network homeostasis, but cellular processes causally linking these changes to organismal senescence remain unclear. Here, we show that AMP-activated protein kinase (AMPK) and dietary restriction (DR) promote longevity in C. elegans via maintaining mitochondrial network homeostasis and functional coordination with peroxisomes to increase fatty acid oxidation (FAO)...
October 23, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29102513/translating-mechanism-based-strategies-to-break-the-obesity-cancer-link-a-narrative-review
#9
Laura A Smith, Ciara H O'Flanagan, Laura W Bowers, Emma H Allott, Stephen D Hursting
Prevalence of obesity, an established risk factor for many cancers, has increased dramatically over the past 50 years in the United States and across the globe. Relative to normoweight cancer patients, obese cancer patients often have poorer prognoses, resistance to chemotherapies, and are more likely to develop distant metastases. Recent progress on elucidating the mechanisms underlying the obesity-cancer connection suggests that obesity exerts pleomorphic effects on pathways related to tumor development and progression and, thus, there are multiple opportunities for primary prevention and treatment of obesity-related cancers...
November 1, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29097740/white-adipose-tissue-coloring-by-intermittent-fasting
#10
Riikka Kivelä, Kari Alitalo
Intermittent fasting (IF) has been shown to promote metabolic health in several organisms. Two recent papers show that IF induces white adipose tissue beiging and increases thermogenesis, which improves metabolic health in mice.
November 2017: Cell Research
https://www.readbyqxmd.com/read/29077158/effects-of-caloric-restriction-on-peroxisome-proliferator-activated-receptors-and-positive-transcription-elongation-factor-b-expression-in-obese-rats
#11
Y-B Yang, X-L Wu, B Ke, Y-J Huang, S-Q Chen, Y-Q Su, J Qin
OBJECTIVE: To investigate the effect of caloric restriction (CR) on expressions of peroxisome proliferators-activated receptors (PPARs) and positive transcription elongation factor b (P-TEFb) (including cyclin-dependent kinase 9 (CDK9) and cyclin T1) protein in visceral adipose tissue of obese rats. MATERIALS AND METHODS: Obese rats were induced by high-fat diet for 8 weeks. Then they were divided into three groups: Model (n=5), 50% Calorie Restricted (50% CR, n=5), Intermittent Fasting (IF) (eight cycles of 3-d fasting and 3-d refeeding, n=6) for 8 weeks...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29072125/the-effects-of-ramadan-intermittent-fasting-rif-on-spirometric-data-of-stable-copd-patients-a-pilot-study
#12
Hajer Zouari, Imed Latiri, Mohamed Mahjoub, Mohamed Boussarsar, Mohamed Benzarti, Ahmed Abdelghani, Helmi Ben Saad
No previous study has raised the effects of RIF on lung function data of chronic obstructive pulmonary disease (COPD) patients. The objective of the present study was to assess the effects of RIF on spirometric data measured in male patients with a stable COPD. Sixteen patients with stable COPD (mean ± SD of age: 64 ± 7 years) who fasted during Ramadan volunteered to the study. Three sessions (Before-R, End-R, and After-R) were selected for spirometry tests that were consistently performed 2.5-4.5 hr before fasting break...
October 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/29065948/circadian-rhythms-nutrition-and-implications-for-longevity-in-urban-environments
#13
O Froy
Presently, about 12% of the population is 65 years or older and by the year 2030 that figure is expected to reach 21%. In order to promote the well-being of the elderly and to reduce the costs associated with health care demands, increased longevity should be accompanied by ageing attenuation. Energy restriction, which limits the amount of energy consumed to 60-70% of the daily intake, and intermittent fasting, which allows the food to be available ad libitum every other day, extend the life span of mammals and prevent or delay the onset of major age-related diseases, such as cancer, diabetes and cataracts...
October 25, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29063418/health-benefits-of-fasting-and-caloric-restriction
#14
REVIEW
Saeid Golbidi, Andreas Daiber, Bato Korac, Huige Li, M Faadiel Essop, Ismail Laher
PURPOSE OF REVIEW: Obesity and obesity-related diseases, largely resulting from urbanization and behavioral changes, are now of global importance. Energy restriction, though, is associated with health improvements and increased longevity. We review some important mechanisms related to calorie limitation aimed at controlling of metabolic diseases, particularly diabetes. RECENT FINDINGS: Calorie restriction triggers a complex series of intricate events, including activation of cellular stress response elements, improved autophagy, modification of apoptosis, and alteration in hormonal balance...
October 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/29049233/pediatric-types-i-and-vi-choledochal-cysts-complicated-with-acute-pancreatitis-and-spontaneous-perforation-a-case-report-and-literature-review
#15
Ching-Chung Tsai, Po-Kai Huang, Hsien-Kuan Liu, Yu-Tsun Su, Ming-Chun Yang, Ming-Lun Yeh
RATIONALE: Choledochal cysts are a congenital disorder of the common bile duct that can cause progressive biliary obstruction and biliary cirrhosis. They were classified by Todani into five types. Of these, type VI choledochal cysts are rarely reported in the literature. PATIENT CONCERNS: A 22-month-old girl presented with intermittent epigastralgia for approximately 10 days and fever for three days. Fasting and total parenteral nutrition were administered after admission...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29039412/intermittent-fasting-promotes-adipose-thermogenesis-and-metabolic-homeostasis-via-vegf-mediated-alternative-activation-of-macrophage
#16
Kyoung-Han Kim, Yun Hye Kim, Joe Eun Son, Ju Hee Lee, Sarah Kim, Min Seon Choe, Joon Ho Moon, Jian Zhong, Kiya Fu, Florine Lenglin, Jeong-Ah Yoo, Philip J Bilan, Amira Klip, Andras Nagy, Jae-Ryong Kim, Jin Gyoon Park, Samer Mi Hussein, Kyung-Oh Doh, Chi-Chung Hui, Hoon-Ki Sung
Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor (VEGF) expression in white adipose tissue (WAT)...
November 2017: Cell Research
https://www.readbyqxmd.com/read/29031771/a-nonrandomized-controlled-clinical-pilot-trial-on-8%C3%A2-wk-of%C3%A2-intermittent-fasting-24%C3%A2-h-wk
#17
Christian S Kessler, Rainer Stange, Maike Schlenkermann, Michael Jeitler, Andreas Michalsen, Antonia Selle, Franca Raucci, Nico Steckhan
OBJECTIVE: The aim of the study was to evaluate whether intermittent fasting (IF) is an effective preventive measure, and whether it is feasible for healthy volunteers under every day conditions. METHODS: A nonrandomized controlled clinical trial on IF was performed with healthy volunteers over a period of 8 wk, and a subsequent 4-mo follow-up. Outcomes were assessed at baseline, after 8 wk, and after 6 mo. Volunteers who were not interested in fasting served as a control group...
August 12, 2017: Nutrition
https://www.readbyqxmd.com/read/29018355/criterion-validity-of-commercially-available-physical-activity-tracker-to-estimate-step-count-covered-distance-and-energy-expenditure-during-sports-conditions
#18
Yvonne Wahl, Peter Düking, Anna Droszez, Patrick Wahl, Joachim Mester
Background: In the past years, there was an increasing development of physical activity tracker (Wearables). For recreational people, testing of these devices under walking or light jogging conditions might be sufficient. For (elite) athletes, however, scientific trustworthiness needs to be given for a broad spectrum of velocities or even fast changes in velocities reflecting the demands of the sport. Therefore, the aim was to evaluate the validity of eleven Wearables for monitoring step count, covered distance and energy expenditure (EE) under laboratory conditions with different constant and varying velocities...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28978420/fasting-the-microbiota-to-improve-metabolism
#19
Joel T Haas, Bart Staels
While intermittent or periodic fasting provides a variety of favorable health benefits, the molecular mediators of these effects are poorly understood. In this issue of Cell Metabolism, Li and colleagues (2017) highlight the role of gut microbiota in mediating benefits of intermittent fasting through activation of adipose tissue beiging.
October 3, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28970945/intermittent-fasting-could-ameliorate-cognitive-function-against-distress-by-regulation-of-inflammatory-response-pathway
#20
Marjan Shojaie, Farzane Ghanbari, Nasrin Shojaie
Undesirable and desirable effects of stressors on the body are assigned to distress and eustress, respectively. Immune system and brain are the most susceptible parts to stressful conditions, whereas long-lasting alterations in putative immune proteins involved in tension such as corticosterone (CORT), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) can impact learning and memory. Intermittent fasting (IF) is a repeated regular cycle of dietary restriction with well-known beneficial properties on the body...
November 2017: Journal of Advanced Research
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