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Intermittant fasting

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https://www.readbyqxmd.com/read/28644979/intraoperative-fast-ripples-independently-predict-postsurgical-epilepsy-outcome-comparison-with-other-electrocorticographic-phenomena
#1
Shaun A Hussain, Gary W Mathern, Phoebe Hung, Julius Weng, Raman Sankar, Joyce Y Wu
In the surgical management of epilepsy, the resection of cortex exhibiting interictal fast ripples (250-500Hz) on electrocorticography has been linked to postoperative seizure-freedom. Although fast ripples appear to accurately identify the epileptogenic zone-the minimum tissue that must be removed at surgery to achieve seizure-freedom-it has not been established that fast ripples are a superior biomarker in comparison with multimodal presurgical neuroimaging and other electrocorticography abnormalities. Hence, in the prediction of postoperative seizure-freedom, we compared the value of fast ripples with other intraoperative electocorticography abnormalities including focal slowing, paroxysmal fast activity, intermittent spike discharges, continuous epileptiform discharges, focal attenuation, and intraoperative seizures, as well as complete resection of the lesion defined by MRI and other neuroimaging...
June 16, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28604365/avalanche-criticality-in-thermal-driven-martensitic-transitions-the-asymmetry-of-the-forward-and-reverse-transitions-in-shape-memory-materials
#2
Antoni Planes, Eduard Vives
Martensitic transitions take place intermittently as a sequence of avalanches, which are accompanied by the emission of acoustic waves. The study of this acoustic emission (AE) reveals the scale-free nature of the avalanches. In a number of shape memory materials undergoing a martensitic transition it has been found that, in spite of the relatively low hysteresis, the dynamics of forward and reverse transitions are different, which may explain the fact that the AE activity is different in both forward and reverse transitions...
June 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28603716/optimizing-nutrition-in-preterm-low-birth-weight-infants-consensus-summary
#3
REVIEW
R Kishore Kumar, Atul Singhal, Umesh Vaidya, Saswata Banerjee, Fahmina Anwar, Shashidhar Rao
Preterm birth survivors are at a higher risk of growth and developmental disabilities compared to their term counterparts. Development of strategies to lower the complications of preterm birth forms the rising need of the hour. Appropriate nutrition is essential for the growth and development of preterm infants. Early administration of optimal nutrition to preterm birth survivors lowers the risk of adverse health outcomes and improves cognition in adulthood. A group of neonatologists, pediatricians, and nutrition experts convened to discuss and frame evidence-based recommendations for optimizing nutrition in preterm low birth weight (LBW) infants...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28590737/reagent-free-quantification-of-aqueous-free-chlorine-via-electrical-readout-of-colorimetrically-functionalized-pencil-lines
#4
Amirmasoud Mohtasebi, Andrew D Broomfield, Tanzina Chowdhury, P Ravi Selvaganapathy, Peter Kruse
Colorimetric methods are commonly used to quantify free chlorine in drinking water. However, these methods are not suitable for reagent-free, continuous, and autonomous applications. Here, we demonstrate how functionalization of a pencil-drawn film with phenyl-capped aniline tetramer (PCAT) can be used for quantitative electric readout of free chlorine concentrations. The functionalized film can be implemented in a simple fluidic device for continuous sensing of aqueous free chlorine concentrations. The sensor is selective to free chlorine and can undergo a reagent-free reset for further measurements...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28541218/fast-post-processing-pipeline-for-optical-projection-tomography
#5
Xiaoqin Tang, Dennis V D Zwaan, Alan Zammit, Kristian F D Rietveld, Fons J Verbeek
To improve the effectiveness and efficiency of the optical projection tomography (OPT) 3D reconstruction, we presented a fast post-processing pipeline including cropping, background subtraction, center of rotation (COR) correction and 3D reconstruction. Regarding to the COR correction, a novel algorithm based on interest point detection of sinogram is proposed by considering the principle of OPT imaging. Instead of locating the COR on single sinogram, we intermittently and evenly select sinograms in the detected full range of specimen to make the located COR more convincing...
May 23, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28541017/extracranial-internal-carotid-artery-calcium-volume-measurement-using-computer-tomography
#6
Hediyeh Baradaran, Chuen R Ng, Ajay Gupta, Norliza M Noor, Khalid W Al-Dasuqi, Edward E Mtui, Omar M Rijal, Argiris Giannopoulos, Andrew Nicolaides, John R Laird, Luca Saba, Jasjit S Suri
BACKGROUND: The extent of calcium volume in the carotid arteries of contrast-based Computer Tomography (CT) is a valuable indicator of stroke risk. This study presents an automated, simple and fast calcium volume computation system. Since the high contrast agent can sometimes obscure the presence of calcium in the CT slices, it is therefore necessary to identify these slices before the corrected volume can be estimated. METHODS: The system typically consists of segmenting the calcium region from the CT scan into slices based on Hounsfield Unit-based threshold, and subsequently computing the summation of the calcium areas in each slice...
May 24, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28539118/when-less-may-be-more-calorie-restriction-and-response-to-cancer-therapy
#7
REVIEW
Ciara H O'Flanagan, Laura A Smith, Shannon B McDonell, Stephen D Hursting
Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases in experimental models. Recent translational studies have tested the potential of CR or CR mimetics as adjuvant therapies to enhance the efficacy of chemotherapy, radiation therapy, and novel immunotherapies. Chronic CR is challenging to employ in cancer patients, and therefore intermittent fasting, CR mimetic drugs, or alternative diets (such as a ketogenic diet), may be more suitable...
May 24, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28537332/comparison-of-intermittent-fasting-versus-caloric-restriction-in-obese-subjects-a-two-year-follow-up
#8
F B Aksungar, M Sarıkaya, A Coskun, M Serteser, I Unsal
OBJECTIVE: Caloric restriction (CR) is proven to be effective in increasing life span and it is well known that, nutritional habits, sleeping pattern and meal frequency have profound effects on human health. In Ramadan some Muslims fast during the day-light hours for a month, providing us a unique model of intermittent fasting (IF) in humans. In the present study, we have investigated the effects of IF versus CR on the same non-diabetic obese subjects who were followed for two years according to the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28530890/strategies-for-management-of-intermittent-fasting-in-patients-with-diabetes
#9
EDITORIAL
Leann Olansky
No abstract text is available yet for this article.
May 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28523425/characterization-of-electrocorticogram-high-gamma-signal-in-response-to-varying-upper-extremity-movement-velocity
#10
Po T Wang, Colin M McCrimmon, Christine E King, Susan J Shaw, David E Millett, Hui Gong, Luis A Chui, Charles Y Liu, Zoran Nenadic, An H Do
The mechanism by which the human primary motor cortex (M1) encodes upper extremity movement kinematics is not fully understood. For example, human electrocorticogram (ECoG) signals have been shown to modulate with upper extremity movements; however, this relationship has not been explicitly characterized. To address this issue, we recorded high-density ECoG signals from patients undergoing epilepsy surgery evaluation as they performed elementary upper extremity movements while systematically varying movement speed and duration...
May 18, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28515159/intermittent-fasting-pretreatment-prevents-cognitive-impairment-in-a-rat-model-of-chronic-cerebral-hypoperfusion
#11
Yuan Hu, Ying Yang, Miao Zhang, Min Deng, Jun-Jian Zhang
Background: Whether intermittent fasting (IF) pretreatment can prevent vascular cognitive dysfunction remains unknown to our knowledge.Objective: We investigated the effects and underlying mechanisms of IF pretreatment on cognitive dysfunction in a permanent 2-vessel occlusion (2VO) vascular dementia rat model.Methods: Male Wistar rats weighing 200 g were subjected to either IF or ad libitum feeding for 12 wk before 2VO surgery. Rats in the IF protocol underwent alternative-day feed deprivation (FD). Memory of the animals was assessed by using the Morris water maze (MWM) and the novel object recognition (NOR) test 6 wk after the surgery...
May 17, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28507100/the-microrna-machinery-regulates-fasting-induced-changes-in-gene-expression-and-longevity-in-caenorhabditis-elegans
#12
Akiko Kogure, Masaharu Uno, Takako Ikeda, Eisuke Nishida
Intermittent fasting (IF) is a dietary restriction regimen that extends the lifespans of Caenorhabditis elegans and mammals by inducing changes in gene expression. However, how IF induces these changes and promotes longevity remains unclear. One proposed mechanism involves gene regulation by microRNAs (miRNAs), small non-coding RNAs (approximately 22 nucleotides) that repress gene expression and whose expression can be altered by fasting. To test this proposition, we examined the role of the miRNA machinery in fasting-induced transcriptional changes and longevity in C...
May 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28498739/feasibility-of-a-cardiovascular-cohort-in-a-sub-saharan-africa-community-preliminary-report-of-the-pilot-project-tahes-tanv%C3%A3-health-study-in-benin
#13
Yessito Corine Houehanou, Carmelle Mizéhoun-Adissoda, Salimanou Amidou, Iléana Désormais, Martin Houénassi, Pierre-Marie Preux, Benoit Marin, Dismand Houinato, Philippe Lacroix
BACKGROUND: Faced with the growing burden of cardiovascular disease (CVD) including atherosclerotic in Sub-Saharan Africa (SSA), the development of appropriate prediction tools, based on large cohorts, appears useful for prevention. OBJECTIVE: The objective of the pilot project TAHES (Tanvè Health Study) was to explore the feasibility of a large cohort study focused on CVD and risk factors in Benin. METHODS: We implemented a prospective cohort over 2 years...
2017: Global Health Action
https://www.readbyqxmd.com/read/28497860/intermittent-preexcitation-indicates-a-low-risk-accessory-pathway-time-for-a-paradigm-shift
#14
Marek Jastrzębski, Piotr Kukla, Maciej Pitak, Andrzej Rudziński, Adrian Baranchuk, Danuta Czarnecka
We report three patients with intermittent loss of the preexcitation pattern in the ECG that had undergone an electrophysiological study. Despite apparently poorly conducting accessory pathway (AP), in each case a fast anterograde conduction, either during spontaneous atrial fibrillation or during incremental atrial pacing (on isoproterenol) was documented; shortest preexcited RR intervals of 200-240 ms were observed. We review the literature and conclude that intermittent preexcitation observed on resting 12-lead ECG lacks sufficient specificity for the diagnosis of an AP with long refractory period and cannot be considered a substitute for electrophysiological study in patients with this electrocardiographical phenomenon...
May 12, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28490463/a-first-in-human-phase-i-dose-escalation-study-of-tak-117-a-selective-pi3k-alpha-isoform-inhibitor-in-patients-with-advanced-solid-malignancies
#15
Dejan Juric, Johann S de Bono, Patricia M LoRusso, John Nemunaitis, Elisabeth I Heath, Eunice L Kwak, Teresa Macarulla Mercadé, Elena Geuna, Maria Jose de Miguel-Luken, Chirag Patel, Keisuke Kuida, Serap Sankoh, Eric H Westin, Fabian Zohren, Yaping Shou, Josep Tabernero
Purpose: To evaluate the safety, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of TAK-117 (MLN1117/INK1117), an investigational PI3Kα-selective inhibitor, in patients with advanced solid tumors. <p>Experimental Design: Seventy-one patients received oral TAK-117 once daily (QD, 100-300 mg [n = 24]), or 3 days per week (Mon-Wed-Fri [MWF], 200-1200 mg [n = 27]; Mon-Tue-Wed [MTuW], 200-900 mg [n = 20]), in 21-day cycles. Dose escalation proceeded via a 3+3 design...
May 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28489201/water-temperature-body-mass-and-fasting-heat-production-of-pacu-piaractus-mesopotamicus
#16
Fredy A A Aguilar, Thaline M P DA Cruz, Gerson B Mourão, José Eurico P Cyrino
Knowledge on fasting heat production (HEf) of fish is key to develop bioenergetics models thus improving feeding management of farmed species. The core of knowledge on HEf of farmed, neotropical fish is scarce. This study assessed the effect of body mass and water temperature on standard metabolism and fasting heat production of pacu, Piaractus mesopotamicus, an omnivore, Neotropical fresh water characin important for farming and fisheries industries all through South American continent. An automated, intermittent flow respirometry system was used to measure standard metabolic rate (SMR) of pacu (17 - 1,050 g) at five water temperatures: 19, 23, 26, 29 and 33 °C...
April 27, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28488831/reduced-leptin-level-is-independently-of-fat-mass-changes-and-hunger-scores-from-high-intensity-intermittent-plus-strength-training
#17
Daniela S Inoue, Valéria L Gonçalves Panissa, Barbara Mello Antunes, Flaviane Poleto de Oliveira, Raoni Bernardes Malta, Renan Santos Caldeira, Eduardo Zapaterra Campos, Gustavo Duarte Pimentel, Emerson Franchini, Fábio Santos Lira
BACKGROUND: This study aimed to analyze the effects of high-intensity intermittent training (HIIT) plus strength training on body composition, hormone related to energetic balance (leptin), and hunger scores in physically active non-obese men. METHODS: Sixteen men were allocated in two different groups, training group (n=10) performed a combined HIIT (5 km, 1 min of effort interspersed by 1 min of rest in passive recovery) followed by strength exercise session (three sets, with load of 8-12 repetition maximum) twice a week, during 8 weeks, while control group (n=6) did not suffer any intervention...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28487698/physiologically-based-simulations-of-deuterated-glucose-for-quantifying-cell-turnover-in-humans
#18
Julio Lahoz-Beneytez, Stephan Schaller, Derek Macallan, Thomas Eissing, Christoph Niederalt, Becca Asquith
In vivo [6,6-(2)H2]-glucose labeling is a state-of-the-art technique for quantifying cell proliferation and cell disappearance in humans. However, there are discrepancies between estimates of T cell proliferation reported in short (1-day) versus long (7-day) (2)H2-glucose studies and very-long (9-week) (2)H2O studies. It has been suggested that these discrepancies arise from underestimation of true glucose exposure from intermittent blood sampling in the 1-day study. Label availability in glucose studies is normally approximated by a "square pulse" (Sq pulse)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28465792/effects-of-intermittent-fasting-on-health-markers-in-those-with-type-2-diabetes-a-pilot-study
#19
Terra G Arnason, Matthew W Bowen, Kerry D Mansell
AIM: To determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM). METHODS: We describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements (using the Yale Physical Activity Survey) were taken at the end of each phase...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28446382/compensatory-mechanisms-activated-with-intermittent-energy-restriction-a-randomized-control-trial
#20
Sílvia Ribeiro Coutinho, Eline Holli Halset, Sigrid Gåsbakk, Jens F Rehfeld, Bård Kulseng, Helen Truby, Cátia Martins
BACKGROUND & AIMS: Strong compensatory responses, with reduced resting metabolic rate (RMR), increased exercise efficiency (ExEff) and appetite, are activated when weight loss (WL) is achieved with continuous energy restriction (CER), which try to restore energy balance. Intermittent energy restriction (IER), where short spells of energy restriction are interspaced by periods of habitual energy intake, may offer some protection in minimizing those responses. We aimed to compare the effect of IER versus CER on body composition and the compensatory responses induced by WL...
April 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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