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Intermittant fasting

Li Ma, Qiuming Gao, Weiqian Tian, Qiang Zhang, Hong Xiao, Zeyu Li, Hang Zhang, Xuehui Tian
Large size reduced graphene oxide MRG-900-10 with lateral size of several micrometers and thickness of 4-6 monosheets is prepared via combined microwave intermittent heating and extraction process. The MRG-900-10 has high C/O molar ratio (5.89) and content of sp2 C (69.0%), which lead to a fast electronic transmission in the sample. Besides, the MRG-900-10 possesses a large specific surface area of 568.2 m2 g-1, which increases the contact surface area between the active material and the electrolyte, thus enhancing the electrons and ions transports in the interfaces when used as the electrode material in supercapacitor...
September 21, 2018: ChemSusChem
Praveen Maurye, Arpita Basu, Malay Naskar, Tapas Kumar Bandyopadhyay, Jayanta Kumar Biswas
Recent advancements in biochemical sciences have facilitated researchers to explore the structure and function of macro molecules in a cell. Polyacrylamide gel electrophoresis (PAGE) is one of the most favored and adapted laboratory techniques. Due to its simple and economical procedures, several variants or new modifications are routinely observed in the basic electrophoresis technique that comprises gel casting, electrophoresis, staining, and imaging process which consequently necessitates additional apparatuses/components in the laboratory...
September 17, 2018: Electrophoresis
Leo Pruimboom, Frits A J Muskiet
Chronic non-communicable diseases (CNCD) are the leading cause of mortality in developed countries. They ensue from the sum of modern anthropogenic risk factors, including high calorie nutrition, malnutrition, sedentary lifestyle, social stress, environmental toxins, politics and economic factors. Many of these factors are beyond the span of control of individuals, suggesting that CNCD are inevitable. However, various studies, ours included, show that the use of intermittent challenges with hormetic effects improve subjective and objective wellbeing of individuals with CNCD, while having favourable effects on immunological, metabolic and behavioural indices...
November 2018: Medical Hypotheses
Kartik Mani, Ali Javaheri, Abhinav Diwan
Adaptive responses that counter starvation have evolved over millennia to permit organismal survival, including changes at the level of individual organelles, cells, tissues, and organ systems. In the past century, a shift has occurred away from disease caused by insufficient nutrient supply toward overnutrition, leading to obesity and diabetes, atherosclerosis, and cardiometabolic disease. The burden of these diseases has spurred interest in fasting strategies that harness physiological responses to starvation, thus limiting tissue injury during metabolic stress...
September 14, 2018: Comprehensive Physiology
Jasmin J Samaras, Bernardo Abecasis, Margarida Serra, Andrea Ducci, Martina Micheletti
Cardiomyocytes (CMs), derived from pluripotent stem cells (PSCs), have the potential to be used in cardiac repair. Addition of physical cues, such as electrical and mechanical stimulations, have proven to significantly effect morphology, density, cardiogenesis, maturity and functionality of differentiated CMs. This work combines rigorous fluid dynamics investigation and flow frequency analysis with iPSC differentiation experiments to identify and quantify the flow characteristics leading to a significant increase of differentiation yield...
September 10, 2018: Journal of Biotechnology
Yun Wang, Li Wen, Shi Zhou, Yong Zhang, Xin-Hao Wang, You-Yu He, Allan Davie, Suzanne Broadbent
AIMS: The aims of this study were to determine the effects of four weeks of intermittent exposure to a moderate hypoxia environment (15% oxygen), and compare with the effects of exercise in normoxia or hypoxia, on glucose homeostasis, insulin sensitivity, GLUT4 translocation, insulin receptor phosphorylation, Akt-dependent GSK3 phosphorylation and Akt activity in skeletal muscle of obese mice with type 2 diabetes. METHODS: C57BL/6J mice that developed type 2 diabetes with a high-fat-diet (55% fat) (fasting blood glucose, FBG = 13...
2018: PloS One
Alexessander Couto Alves, Craig A Glastonbury, Julia S El-Sayed Moustafa, Kerrin S Small
BACKGROUND: Intermittent fasting and time-restricted diets are associated with lower risk biomarkers for cardio-metabolic disease. The shared mechanisms underpinning the similar physiological response to these events is not established, but circadian rhythm could be involved. Here we investigated the transcriptional response to fasting in a large cross-sectional study of adipose and skin tissue from healthy volunteers (N = 625) controlling for confounders of circadian rhythm: time of day and season...
September 7, 2018: BMC Genomics
Shotaro Kamata, Junya Yamamoto, Haruka Ohtani, Yuka Tosaka, Sayumi Yoshikawa, Noriyuki Akahoshi, Isao Ishii
Overnight fasting is a routine procedure before surgery in clinical settings. Intermittent fasting is the most common diet/fitness trend implemented for weight loss and the treatment of lifestyle-related diseases. In either setting, the effects not directly related to parameters of interest, either beneficial or harmful, are often ignored. We previously demonstrated differential activation of cellular adaptive responses in 13 atrophied/nonatrophied organs of fasted mice by quantitative PCR analysis of gene expression...
September 2018: FEBS Open Bio
Mohammad Shenasa, Shahriar Heidary, Hossein Shenasa
BACKGROUND: A 72-year-old white male with a history of rapid nonsustained ventricular tachycardia, hypertrophic cardiomyopathy, and intermittent Brugada-type ECG had a single-lead implantable cardioverter-defibrillator (ICD) implantation and received a sudden ICD shock while in the hot tub. To the best of our knowledge this is the first case report of hot tub jet-induced inappropriate ICD shock. METHODS: ICD interrogation and analysis of intracardiac electrograms and event markers...
September 2018: Journal of Electrocardiology
Silke Ryan
PURPOSE OF REVIEW: Abnormal sleep duration, including short and long sleep, and sleep disorders, in particular obstructive sleep apnea (OSA), have evolved as major public health concerns attributed to their high prevalence and significant links with mortality and comorbid conditions. There is compelling evidence of an independent association of such sleep disturbances with the development, control, and progression of disorders affecting glucose metabolism such as type 2 diabetes (T2D)...
August 22, 2018: Current Opinion in Pulmonary Medicine
Martin Haluzík, Miloš Mráz
No abstract text is available yet for this article.
September 2018: Diabetes
Diána Balázsfi, Dóra Zelena, Kornél Demeter, Christina Miskolczi, Zoltán K Varga, Ádám Nagyváradi, Gábor Nyíri, Csaba Cserép, Mária Baranyi, Beáta Sperlágh, József Haller
Serotonergic mechanisms hosted by raphe nuclei have important roles in affiliative and agonistic behaviors but the separate roles of the two nuclei are poorly understood. Here we studied the roles of the dorsal (DR) and median raphe region (MRR) in aggression by optogenetically stimulating the two nuclei. Mice received three 3 min-long stimulations, which were separated by non-stimulation periods of 3 min. The stimulation of the MRR decreased aggression in a phasic-like manner. Effects were rapidly expressed during stimulations, and vanished similarly fast when stimulations were halted...
2018: Frontiers in Behavioral Neuroscience
Kate Baker, Sarah L Gordon, Holly Melland, Fabian Bumbak, Daniel J Scott, Tess J Jiang, David Owen, Bradley J Turner, Stewart G Boyd, Mari Rossi, Mohammed Al-Raqad, Orly Elpeleg, Dawn Peck, Grazia M S Mancini, Martina Wilke, Marcella Zollino, Giuseppe Marangi, Heike Weigand, Ingo Borggraefe, Tobias Haack, Zornitza Stark, Simon Sadedin, Tiong Yang Tan, Yunyun Jiang, Richard A Gibbs, Sara Ellingwood, Michelle Amaral, Whitley Kelley, Manju A Kurian, Michael A Cousin, F Lucy Raymond
Synaptotagmin 1 (SYT1) is a critical mediator of fast, synchronous, calcium-dependent neurotransmitter release and also modulates synaptic vesicle endocytosis. This paper describes 11 patients with de novo heterozygous missense mutations in SYT1. All mutations alter highly conserved residues, and cluster in two regions of the SYT1 C2B domain at positions Met303 (M303K), Asp304 (D304G), Asp366 (D366E), Ile368 (I368T) and Asn371 (N371K). Phenotypic features include infantile hypotonia, congenital ophthalmic abnormalities, childhood-onset hyperkinetic movement disorders, motor stereotypies, and developmental delay varying in severity from moderate to profound...
September 1, 2018: Brain: a Journal of Neurology
Jing Huang, Xuekun Tang, Zishun Li, Kun Liu
We report a metal-organic framework-derived Co9 S8 nanoflakes on reduced graphene oxide sheet composites as an advanced sodium-ion battery anode. Using a galvanostatic intermittent titration technique, we reveal that the sodium diffusion coefficient of the composite is higher than that of its counterpart. Ex-situ scanning electron microscopy images suggest the excellent mechanical stability of Co9 S8 nanoflakes on the reduced graphene oxide sheet electrode during cycling, thereby facilitating cyclic stability...
December 15, 2018: Journal of Colloid and Interface Science
Melanie Heinrich, Nicole Maison, Peter Achenbach, Robin Assfalg, Sonja Braig, Dominik Böcker, Desiree Dunstheimer, Uwe Ermer, Antonia Gavazzeni, Eva-Maria Gerstl, Sandra Hummel, Kerstin Kick, Herbert Müller, Nicole Nellen-Hellmuth, Christian Ockert, Marina Sindichakis, Stefanie Tretter, Katharina Warncke, Anette-Gabriele Ziegler, Andreas Beyerlein
OBJECTIVE: In children with presymptomatic type 1 diabetes, intermittent hyperglycemia and rising hemoglobin A1c levels are a known signal of progression toward insulin-dependency. Episodes of hypoglycemia, however, have also been reported in one published case. We investigated the prevalence of hypoglycemia and its association with disease progression in children with presymptomatic type 1 diabetes. METHODS: We compared the frequency of hypoglycemic fasting blood glucose levels (<60 mg/dL) in 48 autoantibody negative and 167 multiple β-cell autoantibody positive children aged 2 to 5 years...
August 11, 2018: Pediatric Diabetes
A D Kreisler, M Mattock, E P Zorrilla
Many people restrict their palatable food intake. In animal models, time-limiting access to palatable foods increases their intake while decreasing intake of less preferred alternatives; negative emotional withdrawal-like behavior is sometimes reported. In drug addiction models, intermittent extended access drives greater changes in use than brief access. When it comes to palatable food, the impact of briefer vs. longer access durations within intermittent access conditions remains unclear. Here, we provided male rats with chow or with weekday access to a preferred, sucrose-rich diet (PREF) (2, 4, or 8 h daily) with chow otherwise available...
July 29, 2018: Appetite
David Thivel, Graham Finlayson, Maud Miguet, Bruno Pereira, Martine Duclos, Yves Boirie, Eric Doucet, John E Blundell, Lore Metz
Although there is a growing interest for the effects of intermittent fasting on energy balance, this study aimed to compare appetite, energy intake and food reward responses with an energy depletion induced either by 24-h food restriction or an equivalent deficit with exercise in healthy males. In all, twelve healthy lean males (21·5 (sd 0·5) years old; BMI: 22·5 (sd 1·7) kg/m2) participated in this study. Body composition, aerobic capacity, food preferences and energy intake were assessed. They randomly completed three conditions: (i) no depletion (CON); (ii) full 24-h energy restrictions (Def-EI); and (iii) exercise condition (Def-EX)...
September 2018: British Journal of Nutrition
Nazanin Asghari Hanjani, Mohammadreza Vafa
Data from epidemiological and experimental studies have shown that diet and eating patterns have a major role in the pathogenesis of many age-associated diseases. Since 1935, calorie restriction (CR) has been identified as one of the most effective nongenetic dietary interventions that can increase lifespan. It involves reducing calorie intake by about 20%-40% below ad libitum , without malnutrition. Restricting food intake has been observed to increase lifespan and prevent many age-associated diseases in rats, mice, and many other species...
2018: International Journal of Preventive Medicine
Norbert J Tripolt, Slaven Stekovic, Felix Aberer, Jasmin Url, Peter N Pferschy, Sabrina Schröder, Nicolas Verheyen, Albrecht Schmidt, Ewald Kolesnik, Sophie H Narath, Regina Riedl, Barbara Obermayer-Pietsch, Thomas R Pieber, Frank Madeo, Harald Sourij
BACKGROUND/OBJECTIVES: Alternate day fasting (ADF) is a subtype of intermittent fasting and is defined as a continuous sequence of a fast day (100% energy restriction, zero calories) and a feed day (ad libitum food consumption), resulting in roughly 36-h fasting periods. Previous studies demonstrated weight reductions and improvements of cardiovascular risk factors with ADF in obese subjects. However, rigorous data on potential endocrine, metabolic and cardiovascular effects, besides weight loss, are lacking...
August 2018: Advances in Therapy
Alp Notghi, Shazmeen Hansrod
AIM: This study was undertaken to investigate the extent of variation in meals, radiopharmaceuticals and methodology used for gastric emptying studies in the UK. MATERIALS AND METHODS: Overall, 178 nuclear medicine departments across the UK were contacted by telephone and the gastric emptying protocol was requested. In all, 128 (72%) performed routine gastric emptying studies; 83 protocols were received. RESULTS: Liquid meal gastric emptying: 15 departments performed liquid gastric emptying either as a dual isotope technique (27%) or as a separate test using Tc-diethylenetriamine pentacetic acid (53%) or Tc-colloid (20%)...
October 2018: Nuclear Medicine Communications
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