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Intermittant fasting

Mohamed Hassanein, Elamin Abdelgadir, Alaaeldin Basheir, Fauzia Rashid, Maryam Al Saeed, Azza Khalifa, Fawzi Eltayb, Sona Abuelkheir, Mohammed Abdellatif, Fatima Sayyah, Suad Khalifa, Fatheya Alawadi
BACKGROUND: Physiology of intermittent and prolonged fasting is known from healthy subjects. Evidence on high and very high-risk groups is lacking. The anticipated risks include hypoglycemia, hyperglycemia, dehydration and thrombosis. Education, pre-Ramadan doses adjustment, and glucose monitoring devices (Optimum diabetes care in Ramadan) is expected to lower this risk. AIMS: We aimed to assess the value of optimum care in diabetes management during Ramadan on the metabolic parameters of high risk patients with diabetes...
January 11, 2019: Diabetes Research and Clinical Practice
Ji Hyeon Ahn, Bich Na Shin, Minah Song, Hyunjung Kim, Joon Ha Park, Tae-Kyeong Lee, Cheol Woo Park, Young Eun Park, Jae-Chul Lee, Jun-Hwan Yong, Choong-Hyun Lee, In Koo Hwang, Moo-Ho Won, Yun Lyul Lee
Intermittent fasting (ImF) is known to reduce oxidative stress and affects adult neurogenesis in the hippocampal dentate gyrus. However, it is unknown how ImF affects endogenous antioxidants expressions, cell proliferation, and neuroblast differentiation and their dendrite remodeling over 3 months in the dentate gyrus of adult gerbils. The present study subjected 6‑month old male gerbils to a normal diet or alternate‑day ImF for 1, 2 and 3 months. Changes in body weight were not significantly different between gerbils fed a normal diet and on ImF...
January 4, 2019: Molecular Medicine Reports
Jian-Hong Pan
Simultaneous left and right-sided native valve infective endocarditis (IE) is rare. Staphylococcus aureus was the predominant organism for bilateral IE. Shunt diseases are common risk factors of both-sided IE. Streptococcus anginosus (S. anginosus) is usually associated with pyogenic infections, but rarely a cause of IE. Here we present an extremely rare case of simultaneous left and right-sided native valve IE affecting the mitral and tricuspid valves caused by S. anginosus in an adult patient that has not been reported in the literature previously, particularly without the most frequent predisposing factors of IE...
January 10, 2019: International Heart Journal
Chang Li, Yufang Liu, Chunlei Gao, Xin Li, Yan Xing, Yongmei Zheng
A three-dimensional (3D) web pattern is employed which is inspired by some newest research findings of artificial spider web and it is decorated with hydrophilic Zinc Oxide (ZnO) nanocones inspired by cactus. As expected, multilevel high specific surface area exposure on fiber together with the hydrophilic decoration enables it to be more attractive to water molecules. These nanocones can capture fog droplet, generate coalesced droplet and accordingly make droplet transport efficiently due to Laplace pressure difference...
January 8, 2019: ACS Applied Materials & Interfaces
Chun-Hao Su, Hsien-Lung Chiu, Yen-Chi Chen, Mazlum Yesilmen, Florian Schulz, Bendix Ketelsen, Tobias Vossmeyer, Ying-Chih Liao
In this study, a highly responsive humidity sensor is developed by printing gold nanoparticles (GNP) grafted with a hygroscopic polymer. These GNPs with are inkjet printed to form a uniform thin film over an interdigitated electrode with controllable thickness by adjusting the printing parameters. The resistance of the printed GNP thin film decreases significantly upon exposure to water vapor and exhibits a semi-log relationship with relative humidity (RH). The sensor can detect RH variations from 1.8% to 95% with large resistance changes up to 4 order of magnitudes with no hysteresis and small temperature dependence...
January 4, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
Aaron D Mickle, Sang Min Won, Kyung Nim Noh, Jangyeol Yoon, Kathleen W Meacham, Yeguang Xue, Lisa A McIlvried, Bryan A Copits, Vijay K Samineni, Kaitlyn E Crawford, Do Hoon Kim, Paulome Srivastava, Bong Hoon Kim, Seunghwan Min, Young Shiuan, Yeojeong Yun, Maria A Payne, Jianpeng Zhang, Hokyung Jang, Yuhang Li, H Henry Lai, Yonggang Huang, Sung-Il Park, Robert W Gereau, John A Rogers
The fast-growing field of bioelectronic medicine aims to develop engineered systems that can relieve clinical conditions by stimulating the peripheral nervous system1-5 . This type of technology relies largely on electrical stimulation to provide neuromodulation of organ function or pain. One example is sacral nerve stimulation to treat overactive bladder, urinary incontinence and interstitial cystitis (also known as bladder pain syndrome)4,6,7 . Conventional, continuous stimulation protocols, however, can cause discomfort and pain, particularly when treating symptoms that can be intermittent (for example, sudden urinary urgency)8 ...
January 2, 2019: Nature
J Donnez, G E Courtoy, M-M Dolmans
Uterine fibroids are the most common tumors affecting premenopausal women, responsible for bleeding, pain, and reduced quality of life. When symptomatic, their management mainly involves surgery, which is all too often radical (hysterectomy). While surgical options sparing the uterus (hysteroscopic and laparoscopic myomectomy) and other non-surgical approaches do indeed exist, drug-based therapies are associated with lower costs and morbidity rates. Since progesterone is required for fibroid growth, gonadotropin agonists have been used to control bleeding and decrease fibroid volume, but they only represent a temporary remedy due to adverse events...
January 2, 2019: Climacteric: the Journal of the International Menopause Society
Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo, Simona Bo
BACKGROUND: This systematic review and meta-analysis summarized the most recent evidence on the efficacy of intermittent energy restriction (IER) versus continuous energy restriction on weight-loss, body composition, blood pressure and other cardiometabolic risk factors. METHODS: Randomized controlled trials were systematically searched from MEDLINE, Cochrane Library, TRIP databases, EMBASE and CINAHL until May 2018. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI)...
December 24, 2018: Journal of Translational Medicine
Antonio Real-Hohn, Clarice Navegantes, Katia Ramos, Dionisio Ramos-Filho, Fábio Cahuê, Antonio Galina, Verônica P Salerno
Visceral lipid accumulation, organ hypertrophy and a reduction in skeletal muscle strength are all signs associated with the severity of obesity-related disease. Intermittent fasting (IF) and high-intensity intermittent exercise (HIIE) are natural strategies that, individually, can prevent and help treat obesity along with metabolic syndrome and its associated diseases. However, the combinatorial effect of IF and HIIE on energetic metabolism is currently not well understood. We hypothesized that their combination could have a potential for more than strictly additive benefits...
2018: PloS One
Ashok K Shetty, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N Madhu
The prevalence of age-related diseases is in an upward trend due to increased life expectancy in humans. Age-related conditions are among the leading causes of morbidity and death worldwide currently. Therefore, there is an urgent need to find apt interventions that slow down aging and reduce or postpone the incidence of debilitating age-related diseases. This review discusses the efficacy of emerging anti-aging approaches for maintaining better health in old age. There are many anti-aging strategies in development, which include procedures such as augmentation of autophagy, elimination of senescent cells, transfusion of plasma from young blood, intermittent fasting, enhancement of adult neurogenesis, physical exercise, antioxidant intake, and stem cell therapy...
December 2018: Aging and Disease
Aljohara S Almeneessier, Ahmed S BaHammam
Mealtimes and feeding schedules may interfere with the circadian system and impact sleep. The practice of intermittent fasting (IF) in its different formats is increasing worldwide. However, most studies addressing the effect of IF on circadian rhythms, daytime sleepiness, and sleep architecture have been conducted during diurnal IF for Ramadan. In this article, we analyze the effect of diurnal IF on the circadian clock, sleep, and daytime sleepiness. In free-living, unconstrained environments that do not control for lifestyle changes such as sleep/wake schedules, sleep duration, and light exposure, studies have demonstrated sudden and significant delays in bedtime and wake time during diurnal intermittent fasting for Ramadan...
2018: Nature and Science of Sleep
Courtney M Peterson
No abstract text is available yet for this article.
January 2019: Obesity
Amy T Hutchison, Bo Liu, Rachel E Wood, Andrew D Vincent, Campbell H Thompson, Nathan J O'Callaghan, Gary A Wittert, Leonie K Heilbronn
OBJECTIVE: This study aimed to compare intermittent fasting (IF) versus continuous energy intakes at 100% or 70% of calculated energy requirements on insulin sensitivity, cardiometabolic risk, body weight, and composition. METHODS: Women with overweight (n = 88; 50 ± 1 years, BMI 32.3 ± 0.5 kg/m2 ) were randomized to one of four diets (IF70, IF100, dietary restriction [DR70], or control) in a 2:2:2:1 ratio for 8 weeks. IF groups fasted for 24 hours after breakfast on three nonconsecutive days per week...
January 2019: Obesity
Fernanda Antunes, Adolfo Garcia Erustes, Angélica Jardim Costa, Ana Carolina Nascimento, Claudia Bincoletto, Rodrigo Portes Ureshino, Gustavo José Silva Pereira, Soraya Soubhi Smaili
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as autophagy) is a conserved lysosomal degradation pathway for the intracellular recycling of macromolecules and clearance of damaged organelles and misfolded proteins to ensure cellular homeostasis...
December 10, 2018: Clinics
A Sainsbury, R E Wood, R V Seimon, A P Hills, N A King, A A Gibson, N M Byrne
Eating patterns involving intermittent energy restriction (IER) include 'intermittent fasting' where energy intake is severely restricted for several 'fasting' days per week, with 'refeeding' days (involving greater energy intake than during fasting days) at other times. Intermittent fasting does not improve weight loss compared to continuous energy restriction (CER), where energy intake is restricted every day. We hypothesize that weight loss from IER could be improved if refeeding phases involved restoration of energy balance (i...
December 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Siying Wei, Ruomei Han, Jingyu Zhao, Shuo Wang, Meiqin Huang, Yining Wang, Yan Chen
Fasting and especially intermittent fasting have been shown to be an effective intervention in many diseases, such as obesity and diabetes. The fasting-mimicking diet (FMD) has recently been found to ameliorate metabolic disorders. To investigate the effect of a new type of low-protein low-carbohydrate FMD on diabetes, we tested an FMD in db/db mice, a genetic model of type 2 diabetes. The diet was administered every other week for a total of 8 weeks. The intermittent FMD normalized blood glucose levels in db/db mice, with significant improvements in insulin sensitivity and β cell function...
2018: Nutrition & Metabolism
David Barros, Francisco García-Río
Lipid metabolism deregulation constitutes the pathogenic basis for the development of atherosclerosis and justifies a high incidence of cardiovascular-related morbidity and mortality. Some data suggest that dyslipidemia may be associated with sleep-disordered breathing, mainly obstructive sleep apnea (OSA), due to alterations in fundamental biochemical processes, such as intermittent hypoxia (IH). The aim of this systematic review was to identify and critically evaluate the current evidence supporting the existence of a possible relationship between OSA and alterations in lipid metabolism...
November 24, 2018: Sleep
Bo Liu, Amanda J Page, George Hatzinikolas, Miaoxin Chen, Gary A Wittert, Leonie K Heilbronn
Obesity is associated with increased macrophage and extracellular matrix accumulation in adipose tissue, which can be partially reversed following weight loss by daily caloric restriction. This study examined the effects of 8 weeks of intermittent fasting (IF; 24-hour fast on 3 nonconsecutive days per week) in mice fed a chow or high-fat diet (HFD; 43% fat) on markers of adipose tissue inflammation and fibrosis. We found that IF decreased energy intake, body weight, and fat cell size in HFD-fed mice and decreased fat mass and improved glucose tolerance in chow- and HFD-fed mice...
January 1, 2019: Endocrinology
Michelle Louise Headland, Peter Marshall Clifton, Jennifer Beatrice Keogh
BACKGROUND AND OBJECTIVE: Intermittent energy restriction (IER) is an alternative to continuous energy restriction (CER) for weight loss. There are few long-term trials comparing efficacy of these methods. The objective was to compare the effects of CER to two forms of IER; a week-on-week-off energy restriction and a 5:2 program, during which participants restricted their energy intake severely for 2 days and ate as usual for 5 days, on weight loss, body composition, blood lipids, and glucose...
November 23, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Robert P van Waateringe, Bernardina T Fokkens, Sandra N Slagter, Melanie M van der Klauw, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Andrew D Paterson, Andries J Smit, Helen L Lutgers, Bruce H R Wolffenbuttel
AIMS/HYPOTHESIS: Earlier studies have shown that skin autofluorescence measured with an AGE reader estimates the accumulation of AGEs in the skin, which increases with ageing and is associated with the metabolic syndrome and type 2 diabetes. In the present study, we examined whether the measurement of skin autofluorescence can predict 4 year risk of incident type 2 diabetes, cardiovascular disease (CVD) and mortality in the general population. METHODS: For this prospective analysis, we included 72,880 participants of the Dutch Lifelines Cohort Study, who underwent baseline investigations between 2007 and 2013, had validated baseline skin autofluorescence values available and were not known to have diabetes or CVD...
November 21, 2018: Diabetologia
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