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Intermittant fasting

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https://www.readbyqxmd.com/read/29781380/finally-a-regimen-to-extend-human-life-expectancy
#1
James Larrick, Andrew R Mendelsohn
The US has the most expensive healthcare system worldwide. Yet measures of healthspan and life expectancy are well below the major industrialized nations. With the US population aged 65 and older projected to double by mid-century a healthcare crisis is looming. Within this context huge interest and investment has emerged in technologies and drugs to address aging with an expected benefit to healthspan. The thesis being that such basic interventions will reduce morbidity caused by many chronic diseases where biological age itself is the major risk factor...
May 21, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29780328/contractile-activity-is-necessary-to-trigger-intermittent-hypobaric-hypoxia-induced-fiber-size-and-vascular-adaptations-in-skeletal-muscle
#2
David Rizo-Roca, Jèssica B Bonet, Büsra Ínal, Juan Gabriel Ríos-Kristjánsson, Teresa Pagès, Ginés Viscor, Joan R Torrella
Altitude training has become increasingly popular in recent decades. Its central and peripheral effects are well-described; however, few studies have analyzed the effects of intermittent hypobaric hypoxia (IHH) alone on skeletal muscle morphofunctionality. Here, we studied the effects of IHH on different myofiber morphofunctional parameters, investigating whether contractile activity is required to elicit hypoxia-induced adaptations in trained rats. Eighteen male Sprague-Dawley rats were trained 1 month and then divided into three groups: (1) rats in normobaria (trained normobaric inactive, TNI); (2) rats subjected daily to a 4-h exposure to hypobaric hypoxia equivalent to 4,000 m (trained hypobaric inactive, THI); and (3) rats subjected daily to a 4-h exposure to hypobaric hypoxia just before performing light exercise (trained hypobaric active, THA)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29779947/intermittent-pili-mediated-forces-fluidize-neisseria-meningitidis-aggregates-promoting-vascular-colonization
#3
Daria Bonazzi, Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chaté, Raphael Voituriez, Guillaume Duménil
Neisseria meningitidis, a bacterium responsible for meningitis and septicemia, proliferates and eventually fills the lumen of blood capillaries with multicellular aggregates. The impact of this aggregation process and its specific properties are unknown. We first show that aggregative properties are necessary for efficient infection and study their underlying physical mechanisms. Micropipette aspiration and single-cell tracking unravel unique features of an atypical fluidized phase, with single-cell diffusion exceeding that of isolated cells...
May 15, 2018: Cell
https://www.readbyqxmd.com/read/29779873/short-term-intermittent-fasting-induces-long-lasting-gut-health-and-tor-independent-lifespan-extension
#4
James H Catterson, Mobina Khericha, Miranda C Dyson, Alec J Vincent, Rebecca Callard, Steven M Haveron, Arjunan Rajasingam, Mumtaz Ahmad, Linda Partridge
Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await elucidation. We subjected fruit flies (Drosophila melanogaster) to varying degrees of IF and found that just one month of a 2-day fed:5-day fasted IF regime at the beginning of adulthood was sufficient to extend lifespan. This long-lasting, beneficial effect of early IF was not due to reduced fecundity. Starvation resistance and resistance to oxidative and xenobiotic stress were increased after IF...
May 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29778565/effect-of-intermittent-versus-continuous-energy-restriction-on-weight-loss-maintenance-and-cardiometabolic-risk-a-randomized-1-year-trial
#5
T M Sundfør, M Svendsen, S Tonstad
BACKGROUND & AIMS: Long-term adherence to conventional weight-loss diets is limited while intermittent fasting has risen in popularity. We compared the effects of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk factors in adults with abdominal obesity and ≥1 additional component of metabolic syndrome. METHODS & RESULTS: In total 112 participants (men [50%] and women [50%]) aged 21-70 years with BMI 30-45 kg/m2 (mean 35...
March 29, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29772330/translation-and-validation-of-the-brazilian-portuguese-short-version-of-vascular-quality-of-life-questionnaire-in-peripheral-artery-disease-patients-with-intermittent-claudication-symptoms
#6
Marilia de Almeida Correia, Aluísio Andrade-Lima, Paulo Longano Mesquita de Oliveira, Rômulo Martins Domiciano, Wagner Jorge Ribeiro Domingues, Nelson Wolosker, Pedro Puench-Leão, Raphael Mendes Ritti-Dias, Gabriel Grizzo Cucato
BACKGROUND: The vascular quality of life questionnaire (VascuQoL-6) was proposed to evaluate specific quality of life in peripheral arterial disease patients (PAD). However, there is no Brazilian-Portuguese version available, blunting its use in Brazilian patients. OBJECTIVE: To analyze the psychometric properties of a translated Brazilian-Portuguese version of VascuQoL-6 in Brazilian patients with PAD with intermittent claudication symptoms. METHODS: One hundred and eleven patients with PAD participated in the study...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29765510/correlation-between-metabolic-syndrome-and-sleep-apnea
#7
REVIEW
Alejandro Castaneda, Edgar Jauregui-Maldonado, Iqbal Ratnani, Joseph Varon, Salim Surani
The so-called "metabolic syndrome" (MS), constitutes a cluster of metabolic and cardiovascular abnormalities, including fasting glucose, blood pressure, triglycerides, high density lipoprotein cholesterol (HDL-C), and waist circumference that arise from insulin resistance. Obstructive sleep apnea (OSA) syndrome is characterized by recurrent episodes of partial or complete obstruction of the upper airway, involving cessation or significant decreased airflow, with intermittent hypoxemia, frequent arousals from sleep and recurrent oxyhemoglobin desaturations that interfere with normal sleep patterns generating difficulty falling asleep, unrefreshing sleep and loud snoring...
April 15, 2018: World Journal of Diabetes
https://www.readbyqxmd.com/read/29762016/rapid-2-ms-interrogation-of-electrochemical-aptamer-based-sensor-response-using-intermittent-pulse-amperometry
#8
Mirelis Santos-Cancel, Robert Alexander Lazenby, Ryan J White
In this manuscript, we employ the technique intermittent pulse amperometry (IPA) to interrogate equilibrium and kinetic target binding to the surface of electrochemical, aptamer-based (E-AB) sensors, achieving as fast as 2 ms time resolution. E-AB sensors comprise an electrode surface modified with a flexible nucleic acid aptamer tethered at the 3'-terminus with a redox-active molecule. The introduction of a target changes the conformation and flexibility of the nucleic acid which alters the charge transfer rate of the appended redox molecule...
May 15, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29754952/early-time-restricted-feeding-improves-insulin-sensitivity-blood-pressure-and-oxidative-stress-even-without-weight-loss-in-men-with-prediabetes
#9
Elizabeth F Sutton, Robbie Beyl, Kate S Early, William T Cefalu, Eric Ravussin, Courtney M Peterson
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain their weight. Our proof-of-concept study also constitutes the first trial of early time-restricted feeding (eTRF), a form of IF that involves eating early in the day to be in alignment with circadian rhythms in metabolism...
May 8, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29754134/surprising-pathological-and-clinical-manifestations-of-miliary-tuberculosis
#10
Kamonkiat Wirunsawanya, Dennis Thomas Bolger
We report a surprising pathological finding of miliary tuberculosis (TB) in a 49-year-old Chuukese, immunocompetent woman who was initially admitted to the hospital for a 1-month duration of chronic abdominal pain and intermittent fevers. Her clinical symptoms did not improve despite treatment with vancomycin and piperacillin-tazobactam. Based on the primary abdominal CT findings suggesting advanced ovarian cancer with omental metastatic disease, further workup with omental core biopsy was performed and demonstrated acute neutrophilic necrosis without malignant cells or granulomata...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29753994/effect-of-intermittent-vs-daily-calorie-restriction-on-changes-in-weight-and-patient-reported-outcomes-in-people-with-multiple-sclerosis
#11
Kathryn C Fitzgerald, Diane Vizthum, Bobbie Henry-Barron, Amy Schweitzer, Sandra D Cassard, Eric Kossoff, Adam L Hartman, Dimitrios Kapogiannis, Patrick Sullivan, David J Baer, Mark P Mattson, Lawrence J Appel, Ellen M Mowry
An intermittent fasting or calorie restriction diet has favorable effects in the mouse forms of multiple sclerosis (MS) and may provide additional anti-inflammatory and neuroprotective advantages beyond benefits obtained from weight loss alone. We conducted a pilot randomized controlled feeding study in 36 people with MS to assess safety and feasibility of different types of calorie restriction (CR) diets and assess their effects on weight and patient reported outcomes in people with MS. Patients were randomized to receive 1 of 3 diets for 8 weeks: daily CR diet (22% daily reduction in energy needs), intermittent CR diet (75% reduction in energy needs, 2 days/week; 0% reduction, 5 days/week), or a weight-stable diet (0% reduction in energy needs, 7 days/week)...
May 5, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29740015/effects-of-5-aminolevulinic-acid-supplementation-on-home-based-walking-training-achievement-in-middle-aged-depressive-women-randomized-double-blind-crossover-pilot-study
#12
Hiroshi Suzuki, Shizue Masuki, Akiyo Morikawa, Yu Ogawa, Yoshi-Ichiro Kamijo, Kiwamu Takahashi, Motowo Nakajima, Hiroshi Nose
Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nine outpatients [53 ± 8 (SD) yr] with major depressive disorder participated in the pilot study with randomized, placebo-controlled, double-blind crossover design. They underwent two trials for 7 days, each performing interval walking training (IWT) with ALA + SFC (ALA + SFC) or placebo supplement intake (PLC) intermittently with >a 10-day washout period...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733333/prokaryotic-community-successions-and-interactions-in-marine-biofilms-the-key-role-of-flavobacteriia
#13
Thomas Pollet, Lyria Berdjeb, Cédric Garnier, Gaël Durrieu, Christophe Le Poupon, Benjamin Misson, Jean-François Briand
Despite clear advances in characterizing marine biofilms, details on their formation and species succession remain scarce particularly during the early stage of development. We investigated the microbial community composition and succession in coastal marine biofilms on plastic. Samples were collected over 75 days of immersion with strengthened samplings during the early stages of biofilm establishment. Biofilm composition was estimated using Illumina Miseq and microbial community interactions were assessed through microbial association network analysis...
May 3, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29731834/diagnosis-and-treatment-of-postoperative-intestinal-perforation-in-infants-and-young-children-with-congenital-heart-disease-a-report-of-three-cases
#14
Yong-Hong Zhang, Zhen-Liang Chen, Lei Shi, Zhong-Jian Chen, Xiang-Yang Dong, Bo Zhai
The aim of the present study was to analyze risk factors of intestinal perforation following surgery for the treatment of congenital heart disease in infants and young children, and to summarize experiences of diagnosis and treatment. A total of 3,270 children, who underwent congenital heart disease surgery under extracorporeal circulation from January 2010 to July 2015, were retrospectively analyzed. Among these children, three (0.09%) developed postoperative intestinal perforation. Primary diseases were Tetralogy of Fallot (two cases) and ventricular septal defect combined with atrial septal defect (one case)...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29727683/fasting-activates-fatty-acid-oxidation-to-enhance-intestinal-stem-cell-function-during-homeostasis-and-aging
#15
Maria M Mihaylova, Chia-Wei Cheng, Amanda Q Cao, Surya Tripathi, Miyeko D Mana, Khristian E Bauer-Rowe, Monther Abu-Remaileh, Laura Clavain, Aysegul Erdemir, Caroline A Lewis, Elizaveta Freinkman, Audrey S Dickey, Albert R La Spada, Yanmei Huang, George W Bell, Vikram Deshpande, Peter Carmeliet, Pekka Katajisto, David M Sabatini, Ömer H Yilmaz
Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric states such as intermittent fasting have beneficial effects on organismal health and age-associated loss of tissue function. The role of adult stem and progenitor cells in responding to short-term fasting and whether such responses improve regeneration are not well studied. Here we show that a 24 hr fast augments intestinal stem cell (ISC) function in young and aged mice by inducing a fatty acid oxidation (FAO) program and that pharmacological activation of this program mimics many effects of fasting...
May 3, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29723773/different-ketogenesis-strategies-lead-to-disparate-seizure-outcomes
#16
Alison Dolce, Polan Santos, Weiran Chen, Ahmet Hoke, Adam L Hartman
BACKGROUND: Despite the introduction of new medicines to treat epilepsy over the last 50 years, the number of patients with poorly-controlled seizures remains unchanged. Metabolism-based therapies are an underutilized treatment option for this population. We hypothesized that two different means of systemic ketosis, the ketogenic diet and intermittent fasting, would differ in their acute seizure test profiles and mitochondrial respiration. METHODS: Male NIH Swiss mice (aged 3-4 weeks) were fed for 12-13 days using one of four diet regimens: ketogenic diet (KD), control diet matched to KD for protein content and micronutrients (CD), or CD with intermittent fasting (24 h feed/24 h fast) (CD-IF), tested post-feed or post-fast...
April 27, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29723451/-risks-of-diabetes-mellitus-and-impaired-glucose-tolerance-induced-by-intermittent-versus-continuous-androgen-deprivation-therapy-for-advanced-prostate-cancer
#17
Sheng Zeng, Zhuo-Ping Li, Wei Li, Wei-Zhen Pu, Peng Liu, Zhi-Fang Ma
Objective: To investigate the correlation of intermittent androgen-deprivation therapy (IADT) and continuous androgen-deprivation therapy (CADT) for advanced prostate cancer (PCa) with the risks of secondary diabetes mellitus (DM) and impaired glucose tolerance (IGT). METHODS: We conducted a retrospective case-control study of the advanced PCa patients treated by IADT or CADT in our hospital from January 2013 to December 2015. Based on the levels fasting blood glucose and 2-hour postprandial blood glucose, results of oral glucose tolerance test, and clinical symptoms of the patients, we statistically analyzed the IADT- or CADT-related risk factors for DM and IGT and the relationship of the body mass index (BMI), hypertension, smoking, and alcohol consumption with secondary DM and IGT...
July 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29721607/hydrogen-sulphide-facilitates-exocytosis-by-regulating-the-handling-of-intracellular-calcium-by-chromaffin-cells
#18
Ricardo de Pascual, Andrés M Baraibar, Iago Méndez-López, Martín Pérez-Ciria, Ignacio Polo-Vaquero, Luis Gandía, Sunny E Ohia, Antonio G García, Antonio M G de Diego
Gasotransmitter hydrogen sulphide (H2 S) has emerged as a regulator of multiple physiological and pathophysiological processes throughout. Here, we have investigated the effects of NaHS (fast donor of H2 S) and GYY4137 (GYY, slow donor of H2 S) on the exocytotic release of catecholamines from fast-perifused bovine adrenal chromaffin cells (BCCs) challenged with sequential intermittent pulses of a K+ -depolarizing solution. Both donors caused a concentration-dependent facilitation of secretion. This was not due to an augmentation of Ca2+ entry through voltage-activated Ca2+ channels (VACCs) because, in fact, NaHS and GYY caused a mild inhibition of whole-cell Ca2+ currents...
May 2, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29712667/restructuring-of-the-gut-microbiome-by-intermittent-fasting-prevents-retinopathy-and-prolongs-survival-in-db-db-mice
#19
Eleni Beli, Yuanqing Yan, Leni Moldovan, Cristiano P Vieira, Ruli Gao, Yaqian Duan, Ram Prasad, Ashay Bhatwadekar, Fletcher A White, Steven Townsend, Luisa Chan, Caitlin N Ryan, Daniel Morton, Emil G Moldovan, Fang-I Chu, Gavin Y Oudit, Hartmut Derendorf, Luciano Adorini, Xiaoxin X Wang, Carmella Evans-Molina, Raghavendra G Mirmira, Michael E Boulton, Mervin C Yoder, Qiuhong Li, Moshe Levi, Julia V Busik, Maria B Grant
Intermittent fasting (IF) protects against the development of metabolic diseases and cancer, but whether it can prevent diabetic microvascular complications is not known. In db/db mice, we examined the impact of long-term IF on diabetic retinopathy (DR). Despite no change in glycated hemoglobin, db/db mice on the IF regimen displayed significantly longer survival and a reduction in DR endpoints, including acellular capillaries and leukocyte infiltration. We hypothesized that IF mediated changes in the gut microbiota would produce beneficial metabolites and prevent the development of DR...
April 30, 2018: Diabetes
https://www.readbyqxmd.com/read/29700718/intermittent-fasting-is-the-wait-worth-the-weight
#20
REVIEW
Mary-Catherine Stockman, Dylan Thomas, Jacquelyn Burke, Caroline M Apovian
PURPOSE OF REVIEW: We review the underlying mechanisms and potential benefits of intermittent fasting (IF) from animal models and recent clinical trials. RECENT FINDINGS: Numerous variations of IF exist, and study protocols vary greatly in their interpretations of this weight loss trend. Most human IF studies result in minimal weight loss and marginal improvements in metabolic biomarkers, though outcomes vary. Some animal models have found that IF reduces oxidative stress, improves cognition, and delays aging...
April 26, 2018: Current Obesity Reports
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