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https://www.readbyqxmd.com/read/29915039/large-an-intellectual-disability-associated-protein-regulates-ampa-type-glutamate-receptor-trafficking-and-memory
#1
Bo Am Seo, Taesup Cho, Daniel Z Lee, Joong-Jae Lee, Boyoung Lee, Seong-Wook Kim, Hee-Sup Shin, Myoung-Goo Kang
Mutations in the human LARGE gene result in severe intellectual disability and muscular dystrophy. How LARGE mutation leads to intellectual disability, however, is unclear. In our proteomic study, LARGE was found to be a component of the AMPA-type glutamate receptor (AMPA-R) protein complex, a main player for learning and memory in the brain. Here, our functional study of LARGE showed that LARGE at the Golgi apparatus (Golgi) negatively controlled AMPA-R trafficking from the Golgi to the plasma membrane, leading to down-regulated surface and synaptic AMPA-R targeting...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29913933/a-personal-experience-learning-from-two-pain-pioneers-j-j-bonica-and-w-fordyce-lessons-surviving-four-decades-of-pain-practice
#2
Stephen Butler
This article was requested by the Editor, Professor Harald Brevik after listening to a lecture I gave in a similar vein. Harald wanted the information in print and I have done this in a partly autobiographical form to explain how I came to work and learn from both the late John J. Bonica and the late Wilbert Fordyce. Both of these men have been important in different ways to our present pain world. John J. Bonica made many contributions not only in pain but in regional anesthesia and obstetrical anesthesia but not on the same level...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913870/treatment-of-post-traumatic-pain-and-autonomic-and-muscular-dysfunction-by-ganglion-impar-block-and-medial-branch-block-of-the-facet-joints-a-case-report
#3
Johan Hambræus, Hans Westergren
Introduction Patients exposed to whiplash trauma are at risk of developing pain and dysfunction of the neck and shoulder. Although rarely discussed in the literature, some patients also develop autonomic dysfunction. Case presentation A previously healthy 41-year-old woman was involved in a "head-on" car crash. During the following 3 years she developed severe and complex post-traumatic pain syndrome, which consisted of neck pain, lumbar pain, sensory-motor dysfunction, and myoclonic muscular contractions...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910721/better-diffusion-segmentation-in-acute-ischemic-stroke-through-automatic-tree-learning-anomaly-segmentation
#4
Jens K Boldsen, Thorbjørn S Engedal, Salvador Pedraza, Tae-Hee Cho, Götz Thomalla, Norbert Nighoghossian, Jean-Claude Baron, Jens Fiehler, Leif Østergaard, Kim Mouridsen
Stroke is the second most common cause of death worldwide, responsible for 6.24 million deaths in 2015 (about 11% of all deaths). Three out of four stroke survivors suffer long term disability, as many cannot return to their prior employment or live independently. Eighty-seven percent of strokes are ischemic. As an increasing volume of ischemic brain tissue proceeds to permanent infarction in the hours following the onset, immediate treatment is pivotal to increase the likelihood of good clinical outcome for the patient...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29908156/classifying-the-molecular-functions-of-rab-gtpases-in-membrane-trafficking-using-deep-convolutional-neural-networks
#5
Nguyen-Quoc-Khanh Le, Quang-Thai Ho, Yu-Yen Ou
Deep learning has been increasingly used to solve a number of problems with state-of-the-art performance in a wide variety of fields. In biology, deep learning can be applied to reduce feature extraction time and achieve high levels of performance. In our present work, we apply deep learning via two-dimensional convolutional neural networks and position-specific scoring matrices to classify Rab protein molecules, which are main regulators in membrane trafficking for transferring proteins and other macromolecules throughout the cell...
June 13, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29905879/health-care-utilization-for-chronic-pain-in-low-income-settings
#6
Andrea K Newman, Shweta Kapoor, Beverly E Thorn
Background: Chronic pain is a serious health problem with high rates of health care utilization (HCU). Many patients become stymied in a perpetual cycle of unsuccessful attempts to find relief from suffering through frequent health care visits. Especially within low-income populations, the burdens of health care services are especially unpleasant due to significant financial costs, barriers to transportation, and high levels of stress. This study aimed to examine factors associated with HCU for chronic pain in low-income settings...
June 13, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29894448/neurologic-outcomes-after-extracorporeal-membrane-oxygenation-a-systematic-review
#7
Katharine Boyle, Ryan Felling, Alvin Yiu, Wejdan Battarjee, Jamie McElrath Schwartz, Cynthia Salorio, Melania M Bembea
OBJECTIVES: The goal of this systematic review of the literature was to summarize neurologic outcomes following neonatal and pediatric extracorporeal membrane oxygenation. DATA SOURCES: We conducted electronic searches of PubMed, Scopus, Web of Science, CINAHL, Cochrane, and EMBASE. STUDY SELECTION: Inclusion criteria included publication dates 2000-2016, patient ages 0-18 years, and use of standardized measures to evaluate outcomes after extracorporeal membrane oxygenation...
June 11, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29894262/tragic-failures-in-learning-disability-healthcare-provision
#8
John Tingle
John Tingle, Associate Professor (Teaching and Scholarship), Nottingham Trent University, discusses some recent reports highlighting major failings in healthcare provision for people with learning disabilities.
June 14, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29889580/a-pilot-test-of-the-gowoman-weight-management-intervention-for-women-with-mobility-impairments-in-the-online-virtual-world-of-second-life-%C3%A2
#9
Margaret A Nosek, Susan Robinson-Whelen, Tracey A Ledoux, Rosemary B Hughes, Daniel P O'Connor, Rebecca E Lee, Rebecca Goe, Stephanie L Silveira, Rachel Markley, Thomas M Nosek
OBJECTIVE: Pilot test GoWoman, a small-group weight management intervention for mobility impaired women that was a disability- and gender-responsive adaptation of the Diabetes Prevention Program delivered in the online virtual world of Second Life® . Objectives were to (1) examine pre-/post-intervention differences in weight, waist circumference, diet, physical activity, self-efficacy for diet and physical activity, nutrition knowledge and social support for weight management, (2) determine intervention feasibility (fidelity, attrition, engagement, acceptability)...
June 11, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29888094/predicting-neonatal-encephalopathy-from-maternal-data-in-electronic-medical-records
#10
Thomas Li, Cheng Gao, Chao Yan, Sarah Osmundson, Bradley A Malin, You Chen
Neonatal encephalopathy (NE) is a leading cause of neonatal mortality and lifetime neurological disability. The earlier the risk of NE can be assessed, the more effective interventions can be in preventing adverse outcomes. Existing studies that focus on intrapartum risk factors do not provide the early prognostic forecasting necessary to prepare healthcare professionals to intervene early in a high-risk NE case. This work used maternal data in a supervised machine learning framework to predict NE events. Specifically, we 1) collected the electronic medical records (EMRs) for 104 NE newborns and 31,054 non-NE newborns and their mothers, 2) trained and tested a regularized logistic regression on imbalanced and high-dimensional EMR data, and 3) discerned important features that could be possible risk factors...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29887623/calcaneal-fractures-should-we-or-should-we-not-operate
#11
Stefan Rammelt, Bruce J Sangeorzan, Michael P Swords
The best treatment for displaced, intraarticular fractures of the calcaneum remains controversial. Surgical treatment of these injuries is challenging and have a considerable learning curve. Studies comparing operative with nonoperative treatment including randomized trials and meta-analyses are fraught with a considerable number of confounders including highly variable fracture patterns, soft-tissue conditions, patient characteristics, surgeon experience, limited sensitivity of outcome measures, and rehabilitation protocols...
May 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29885568/an-investigation-of-professional-integrity-in-pre-registration-nurse-education-a-modified-grounded-theory-research-study
#12
E Jane Blowers
BACKGROUND: Acting with integrity is a central part of nursing practice. However, literature shows that professional integrity can be absent and where this is present it can face challenges. Governmental Inquiries have revealed deficits in the expression of nursing values which underpin professional integrity, in particular caring, compassionate and competent practice that maintains the dignity of patients. Evidence also suggests that it cannot be taken for granted that pre-registration education will have a positive impact on student nurses' ability to practice with integrity...
June 1, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29885419/secondary-brain-injury-predicting-and-preventing-insults
#13
REVIEW
Christos Lazaridis, Craig G Rusin, Claudia S Robertson
Mortality or severe disability affects the majority of patients after severe traumatic brain injury (TBI). Adherence to the brain trauma foundation guidelines has overall improved outcomes; however, traditional as well as novel interventions towards intracranial hypertension and secondary brain injury have come under scrutiny after series of negative randomized controlled trials. In fact, it would not be unfair to say there has been no single major breakthrough in the management of severe TBI in the last two decades...
June 6, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29882521/brain-spect-scans-in-students-with-specific-learning-disability-preliminary-results
#14
S Karande, N Deshmukh, V Rangarajan, A Agrawal, R Sholapurwala
Background and Objectives: Brain single-photon emission computed tomography (SPECT) assesses brain function through measurement of regional cerebral blood flow. This study was conducted to assess whether students with newly diagnosed specific learning disability (SpLD) show any abnormalities in cerebral cortex perfusion. Settings and Design: Cross-sectional single-arm pilot study in two tertiary care hospitals. Subjects and Methods: Nine students with SpLD were enrolled...
June 8, 2018: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29879783/clinical-and-radiological-outcomes-of-modified-mini-open-and-open-transforaminal-lumbar-interbody-fusion-a-comparative-study
#15
Sudhir Ganesan, Vignesh Jayabalan, Venkatesh Kumar, Karthik Kailash
STUDY DESIGN: Retrospective cohort study. PURPOSE: To compare the clinical and radiological outcomes of modified mini-open transforaminal lumbar interbody fusion (modMOTLIF) and open TLIF (OTLIF). OVERVIEW OF LITERATURE: Minimally invasive transforaminal lumbar interbody fusion (MTLIF) is associated with less blood loss, shorter hospital stay, and less pain. However, it has concerns like increased radiation exposure, steep learning curve, and instrumentation cost...
June 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29878967/home-based-nurse-practitioners-demonstrate-reductions-in-rehospitalizations-and-emergency-department-visits-in-a-clinically-complex-patient-population-through-an-academic-clinical-partnership
#16
Denise Coppa, Suzy Barcelos Winchester, Mary B Roberts
BACKGROUND AND PURPOSE: The purpose of this pilot study was to describe the impact of one aspect of an academic-clinical partnership that showed how assigning nurse practitioner faculty to deliver home-based primary care services to clinically complex patients would decrease rehospitalizations and emergency department visit rates. METHODS: Rehospitalizations and emergency department visits of a cohort of 82 patients were recorded from April 15, 2016 to August 25, 2016 and compared with the same cohort during the two pre-home care inception periods (6 months and 1 year) using insurance claims-based data...
June 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29877581/integrating-community-service-learning-in-undergraduate-dental-education-a-controlled-trial-in-a-residential-facility-for-people-with-intellectual-disabilities
#17
Inès Phlypo, Jannick De Tobel, Luc Marks, Luc De Visschere, Sebastiaan Koole
AIMS: The present report describes an oral health promotion project in a residential facility for people with intellectual disabilities as a strategy to implement community service learning in undergraduate dental education. METHODS AND RESULTS: Two undergraduate students developed a project aimed to improve the oral health in residents with intellectual disabilities by educating caregivers. The impact was investigated by a pretest-posttest design, evaluating residents' plaque and gingival indexes and caregivers' knowledge, behavior, attitude, and self-efficacy...
June 7, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29876872/pharmacotherapy-for-persistent-posttraumatic-headaches-in-children-and-adolescents-a-brief-review-of-the-literature
#18
Joanne Kacperski
Concussion, now most often referred to as mild traumatic brain injury in recent literature, is common in pediatrics, and headache is often the most common complaint post-injury. Although most children and adolescents recover within 1-2 weeks, some develop frequent and debilitating headaches that can last for months or longer. Most clinicians would agree on the importance of managing both acute and persistent posttraumatic headaches appropriately to speed recovery, minimize disability, maximize function, and improve quality of life, but there are no well-established guidelines to instruct physicians in doing so...
June 7, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29873159/-i-kind-of-figured-it-out-the-views-and-experiences-of-people-with-traumatic-brain-injury-tbi-in-using-social-media-self-determination-for-participation-and-inclusion-online
#19
Melissa Brunner, Stuart Palmer, Leanne Togher, Bronwyn Hemsley
BACKGROUND: Social media can support people with communication disability to access information, social participation and support. However, little is known about the experiences of people with traumatic brain injury (TBI) who use social media to determine their needs in relation to social media use. AIMS: To determine the views and experiences of adults with TBI and cognitive-communication disability on using social media, specifically: (1) the nature of their social media experience; (2) barriers and facilitators to successful use; and (3) strategies that enabled their use of social media...
June 5, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29871377/minimally-invasive-full-endoscopic-posterior-cervical-foraminotomy-assisted-by-o-arm-based-navigation
#20
Chao Zhang, Junlong Wu, Chuang Xu, Wenjie Zheng, Yong Pan, Changqing Li, Yue Zhou
BACKGROUND: Navigated percutaneous endoscopic cervical discectomy (PECD) is a promising minimally invasive surgery for treating cervical spondylotic radiculopathy. PECD has been described as a safe, effective, and minimally invasive method for patients with radiculopathy, but it comes with a steep learning curve. Due to the limited field of vision, anatomic localization is difficult for surgeons until using the O-arm based navigation. In this study, patients with radiculopathy due to foraminal disc herniation or foraminal stenosis in the lower cervical spine underwent the single level full endoscopic posterior cervical foraminotomy procedure assisted by O-arm-based navigation...
May 2018: Pain Physician
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